Detailed information for compound 1446565

Basic information

Technical information
  • TDR Targets ID: 1446565
  • Name: N-(3-chloro-4-methoxyphenyl)-2-(3-methyl-2-ox oquinoxalin-1-yl)acetamide
  • MW: 357.791 | Formula: C18H16ClN3O3
  • H donors: 1 H acceptors: 2 LogP: 2.38 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1Cl)NC(=O)Cn1c(=O)c(C)nc2c1cccc2
  • InChi: 1S/C18H16ClN3O3/c1-11-18(24)22(15-6-4-3-5-14(15)20-11)10-17(23)21-12-7-8-16(25-2)13(19)9-12/h3-9H,10H2,1-2H3,(H,21,23)
  • InChiKey: ZKQDDWQIYBTRDU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chloro-4-methoxy-phenyl)-2-(3-methyl-2-oxo-quinoxalin-1-yl)acetamide
  • N-(3-chloro-4-methoxyphenyl)-2-(3-methyl-2-oxo-1-quinoxalinyl)acetamide
  • N-(3-chloro-4-methoxy-phenyl)-2-(2-keto-3-methyl-quinoxalin-1-yl)acetamide
  • N-(3-chloro-4-methoxy-phenyl)-2-(3-methyl-2-oxo-quinoxalin-1-yl)ethanamide
  • T0512-9262
  • MLS001005120
  • SMR000377978
  • ZINC03257007

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0009 0.0071 0.0071
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0336 0.1771
Entamoeba histolytica protein kinase, putative 0.0008 0.0038 0.0322
Brugia malayi Cathepsin L-like precursor 0.0017 0.0317 0.0317
Onchocerca volvulus 0.0062 0.1856 0.2005
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0008 0.0038 0.0015
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0023 0.0023
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0521 0.0508
Trypanosoma brucei P-type H+-ATPase, putative 0.0011 0.0112 0.0471
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.1184 0.1164
Onchocerca volvulus 0.0017 0.0317 0.0321
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0011 0.0137 0.0137
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0038 0.0016
Brugia malayi Na,K-ATPase alpha subunit 0.0017 0.0317 0.0317
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0044 0.0371
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0317 0.268
Loa Loa (eye worm) AGC/AKT protein kinase 0.0008 0.0038 0.0038
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0317 0.0295
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0997 0.0993
Loa Loa (eye worm) hypothetical protein 0.0079 0.2449 0.2449
Loa Loa (eye worm) hypothetical protein 0.0042 0.1189 0.1189
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0009 0.0071 0.0603
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.0317 0.0291
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0042 0.1189 0.6407
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0521 0.2652
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0201 0.6612 0.6604
Leishmania major DNA polymerase kappa, putative 0.0023 0.0521 0.2288
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0017 0.0317 0.0295
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0013 0.0205 0.0964
Brugia malayi Cathepsin L-like precursor 0.0017 0.0317 0.0317
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0336 0.0314
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0336 0.0314
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0038 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0317 0.0291
Echinococcus granulosus cathepsin L 0.0009 0.0044 0.0021
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0997 0.0985
Toxoplasma gondii protease inhibitor PI2 0.0042 0.1189 0.6407
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0131 0.1104
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0017 0.0317 0.1564
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0371
Brugia malayi protein kinase C II. 0.0015 0.0281 0.0281
Plasmodium vivax vivapain-2 0.0017 0.0317 0.3043
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0336 0.4383
Loa Loa (eye worm) hypothetical protein 0.0062 0.1856 0.1856
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Brugia malayi secreted modular calcium-binding protein 1 0.0042 0.1189 0.1189
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0521 0.0499
Leishmania major P-type ATPase, putative 0.0013 0.0205 0.0517
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0317 0.0291
Loa Loa (eye worm) hypothetical protein 0.0017 0.0328 0.0328
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0317 0.0291
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0008 0.0023 0.0023
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0044 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0521 0.2652
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0008 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0317 0.0291
Loa Loa (eye worm) hypothetical protein 0.0011 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1898 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.1064 0.1064
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0017 0.0317 0.1672
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.0044 0.0231
Entamoeba histolytica cysteine proteinase 2 0.0009 0.0044 0.0371
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase A CtpF 0.0012 0.0147 0.028
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0336 0.0336
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0317 0.0291
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0521 0.2652
Schistosoma mansoni organic anion transporter 0.0062 0.1856 0.187
Echinococcus multilocularis cysteine protease 0.0017 0.0317 0.0295
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Echinococcus granulosus Protein kinase C brain isozyme 0.0054 0.1591 0.1572
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0336 0.5191
Schistosoma mansoni smad1 5 8 and 0.0009 0.0077 0.0056
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0062 0.1856 0.1856
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0028 0.0711 0.3829
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0336 0.1665
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0598 0.0587
Loa Loa (eye worm) AGC/PKN protein kinase 0.0008 0.0038 0.0038
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0008 0.0038 0.0015
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.1184 0.1184
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.2525 0.2508
Echinococcus multilocularis calcium transporting atpase 0.0025 0.0598 0.0577
Onchocerca volvulus 0.0062 0.1856 0.2005
Entamoeba histolytica hypothetical protein 0.0042 0.1184 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.1712 0.902
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0336 0.1253
Brugia malayi Protein kinase c protein 2 0.0046 0.1313 0.1313
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0521 0.2652
Brugia malayi hypothetical protein 0.0008 0.0023 0.0023
Brugia malayi hypothetical protein 0.0008 0.0023 0.0023
Echinococcus multilocularis jun protein 0.0081 0.2525 0.2508
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0521 0.0499
Brugia malayi Dopamine receptor 0.0008 0.0023 0.0023
Schistosoma mansoni jun-related protein 0.0066 0.2006 0.2023
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.0205 0.1079
Brugia malayi Dopamine receptor protein 1 0.0008 0.0023 0.0023
Onchocerca volvulus Putative organic anion transporter 0.0062 0.1856 0.2005
Schistosoma mansoni organic anion transporter 0.0062 0.1856 0.187
Brugia malayi cathepsin L-like precursor 0.0011 0.0131 0.0131
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0997 0.5191
Brugia malayi hypothetical protein 0.0008 0.0023 0.0023
Echinococcus multilocularis RNA directed DNA polymerase 0.0038 0.1064 0.1044
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0997 0.8419
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.094 0.5067
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0028 0.0711 0.0592
Echinococcus multilocularis agrin 0.0042 0.1189 0.1169
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0997 0.5252
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0317 0.0291
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0317 0.268
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0062 0.1856 0.1837
Brugia malayi Melatonin receptor type 1A 0.0008 0.0023 0.0023
Onchocerca volvulus 0.0062 0.1856 0.2005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0317 0.0291
Echinococcus multilocularis geminin 0.0205 0.6727 0.672
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0997 0.0985
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0317 0.0291
Echinococcus multilocularis serine:threonine protein kinase 38 0.0008 0.0038 0.0015
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0317 0.268
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0038 0.0016
Plasmodium falciparum calcium-transporting ATPase 0.0025 0.0598 0.8313
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Trypanosoma cruzi cysteine protease, putative 0.0009 0.0044 0.0231
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0317 0.1144
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0131 0.0131
Leishmania major calcium-transporting ATPase, putative 0.0013 0.0205 0.0517
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0371
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0521 1
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0521 0.2652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1898 1
Onchocerca volvulus 0.0062 0.1856 0.2005
Brugia malayi neuropeptide F receptor 0.0008 0.0023 0.0023
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0521 0.2652
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0044 0.0371
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Onchocerca volvulus 0.0017 0.0317 0.0321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0317 0.0291
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0521 0.2652
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0336 0.0314
Trypanosoma cruzi P-type H+-ATPase, putative 0.0011 0.0112 0.0593
Brugia malayi Dopamine receptor protein 2 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Onchocerca volvulus 0.0017 0.0317 0.0321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0317 0.0291
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Echinococcus granulosus geminin 0.0205 0.6727 0.672
Brugia malayi Cathepsin L-like precursor 0.0011 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0024
Leishmania major cathepsin L-like protease 0.0017 0.0317 0.1144
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0077 0.0055
Loa Loa (eye worm) ctsf protein 0.0017 0.0317 0.0317
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.3572 0.3572
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0317 0.4092
Brugia malayi prostaglandin transporter 0.0062 0.1856 0.1856
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0521 0.2652
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0077 0.0056
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0013 0.0205 0.0186
Onchocerca volvulus Putative organic anion transporter 0.0062 0.1856 0.2005
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0015 0.0281 0.0281
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0008 0.0038 0.0015
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0028 0.0711 0.3745
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0042 0.1189 0.1189
Loa Loa (eye worm) hypothetical protein 0.0011 0.0131 0.0131
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0317 0.4092
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0521 0.2652
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0038 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0521 0.0521
Entamoeba histolytica hypothetical protein 0.0042 0.1184 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.2525 0.2508
Brugia malayi Pre-SET motif family protein 0.0035 0.094 0.094
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0371
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0521 0.0397
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.0044 0.0231
Brugia malayi hypothetical protein 0.0008 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0317 0.0291
Trichomonas vaginalis cation-transporting ATPase, putative 0.0028 0.0711 0.0693
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0521 0.0508
Toxoplasma gondii P-type ATPase PMA1 0.0011 0.0112 0.0606
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0317 0.0291
Brugia malayi neuropeptide F receptor 0.0008 0.0023 0.0023
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0042 0.1189 0.6407
Loa Loa (eye worm) hypothetical protein 0.0062 0.1856 0.1856
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0017 0.0317 0.03
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0371
Leishmania major cathepsin L-like protease 0.0063 0.1898 1
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.0205 0.1079
Leishmania major cathepsin L-like protease 0.0017 0.0317 0.1144
Brugia malayi follicle stimulating hormone receptor 0.0008 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0035 0.0962 0.0958
Toxoplasma gondii P-type ATPase4, putative 0.0017 0.0317 0.171
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0336 0.0314
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0521 0.2745
Trypanosoma brucei unspecified product 0.0016 0.0283 0.1381
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0997 0.5252
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Onchocerca volvulus 0.0017 0.0317 0.0321
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0028 0.0711 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0336 0.1811
Echinococcus multilocularis dna polymerase eta 0.0023 0.0521 0.0499
Schistosoma mansoni ATPase 0.0028 0.0711 0.0702
Schistosoma mansoni unc-13 (munc13) 0.0009 0.0067 0.0045
Echinococcus multilocularis Smad4 0.0009 0.0077 0.0055
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0997 0.4953
Brugia malayi MH2 domain containing protein 0.0009 0.0077 0.0077
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1898 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0997 0.0997
Schistosoma mansoni agrin 0.0042 0.1189 0.119
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0317 0.0291
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0997 0.0985
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0317 0.03
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0317 0.0291
Echinococcus granulosus RNA directed DNA polymerase 0.0038 0.1064 0.1044
Onchocerca volvulus 0.0017 0.0317 0.0322
Brugia malayi Serotonin receptor 0.0008 0.0023 0.0023
Trichomonas vaginalis set domain proteins, putative 0.0276 0.9167 0.9328
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.3572 0.3572
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0283 0.1381
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0008 0.0038 0.0038
Brugia malayi MH2 domain containing protein 0.0139 0.4498 0.4498
Schistosoma mansoni hypothetical protein 0.0205 0.6727 0.684
Brugia malayi AKH receptor 0.0008 0.0023 0.0023
Schistosoma mansoni atypical protein kinase C 0.0014 0.0239 0.022
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0962 0.0941
Echinococcus granulosus protein kinase c epsilon type 0.0015 0.0281 0.0258
Brugia malayi Tachykinin-like peptides receptor 99D 0.0008 0.0023 0.0023
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0008 0.0038 0.0015
Onchocerca volvulus 0.0276 0.9167 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0962 0.0941
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0521 0.2288
Brugia malayi sodium-independent organic anion transporter family protein 0.0062 0.1856 0.1856
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1898 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Plasmodium vivax vivapain-2 0.0017 0.0317 0.3043
Brugia malayi Pre-SET motif family protein 0.0243 0.8025 0.8025
Trypanosoma brucei unspecified product 0.0023 0.0521 0.2652
Schistosoma mansoni hypothetical protein 0.0077 0.2364 0.2388
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0038 0.0006
Leishmania major cathepsin L-like protease 0.0063 0.1898 1
Echinococcus granulosus GPCR family 2 0.0035 0.0962 0.0941
Loa Loa (eye worm) AGC/NDR protein kinase 0.0008 0.0038 0.0038
Echinococcus granulosus Solute carrier organic anion transporter family 0.0062 0.1856 0.1837
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0371
Brugia malayi RE15519p 0.0008 0.0023 0.0023
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0077 0.0055
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0038 0.0006
Onchocerca volvulus 0.0064 0.193 0.2086
Toxoplasma gondii AGC kinase 0.0008 0.0038 0.0205
Loa Loa (eye worm) hypothetical protein 0.0042 0.1189 0.1189
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Trypanosoma brucei unspecified product 0.0016 0.0283 0.1381
Brugia malayi hypothetical protein 0.0008 0.0023 0.0023
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0077 0.0077
Brugia malayi Hr1 repeat family protein 0.0008 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0317 0.0291
Loa Loa (eye worm) agrin synaptic family protein 0.0042 0.1189 0.1189
Leishmania major cathepsin L-like protease 0.0017 0.0317 0.1144
Loa Loa (eye worm) hypothetical protein 0.0028 0.0711 0.0711
Brugia malayi G protein-coupled receptor 0.0008 0.0023 0.0023
Echinococcus granulosus serine:threonine protein kinase N2 0.0008 0.0038 0.0015
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0042 0.1189 0.1189
Brugia malayi Serotonin receptor 0.0008 0.0023 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.1591 0.16
Trypanosoma brucei calcium-translocating P-type ATPase 0.0025 0.0598 0.3064
Schistosoma mansoni follistatin 0.0042 0.1189 0.119
Echinococcus granulosus zinc finger transcription factor gli2 0.0301 1 1
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0019 0.0418 0.0418
Schistosoma mansoni hypothetical protein 0.0042 0.1184 0.1184
Onchocerca volvulus 0.0011 0.0131 0.0118
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0042 0.1189 0.6407
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0042 0.1189 0.1189
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0336 0.0314
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0201 0.6612 0.6604
Brugia malayi Protein kinase domain containing protein 0.0008 0.0038 0.0038
Onchocerca volvulus 0.0017 0.0317 0.0321
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0062 0.1856 0.1837
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0011 0.0137 0.0137
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0044 0.0044
Schistosoma mansoni serine/threonine kinase 0.0008 0.0038 0.0016
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0008 0.0023 0.0023
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0317 0.1669
Brugia malayi SPARC precursor 0.0042 0.1189 0.1189
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0283 0.1381
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0317 0.0321
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.1184 0.1164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1898 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0017 0.0317 0.0317
Plasmodium vivax calcium-transporting ATPase, putative 0.0028 0.0711 0.7437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0317 0.0291
Echinococcus multilocularis cathepsin L 0.0009 0.0044 0.0021
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0371
Brugia malayi sodium-independent organic anion transporter family protein 0.0062 0.1856 0.1856
Echinococcus multilocularis zinc finger transcription factor gli2 0.0301 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0044 0.0371
Loa Loa (eye worm) hypothetical protein 0.0042 0.1189 0.1189
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Loa Loa (eye worm) fibroinase 0.0017 0.0317 0.0317
Leishmania major DNA polymerase eta, putative 0.0023 0.0521 0.2288
Echinococcus multilocularis cysteine protease 0.0017 0.0317 0.0295
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0017 0.0317 0.1564
Brugia malayi MH2 domain containing protein 0.0009 0.0077 0.0077
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0278 0.9221 0.9221
Brugia malayi larval opioid receptor 0.0008 0.0023 0.0023
Brugia malayi G-protein coupled receptor 0.0008 0.0023 0.0023
Brugia malayi hypothetical protein 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Brugia malayi hypothetical protein 0.0008 0.0023 0.0023
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0028 0.0711 0.0689
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0997 0.0993
Toxoplasma gondii transporter, major facilitator family protein 0.0062 0.1856 1
Entamoeba histolytica protein kinase, putative 0.0008 0.0038 0.0322
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1898 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0317 0.0291
Loa Loa (eye worm) hypothetical protein 0.0062 0.1856 0.1856
Schistosoma mansoni smad1 5 8 and 0.0009 0.0077 0.0056
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0017 0.0317 0.1147
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1898 1
Onchocerca volvulus 0.0017 0.0317 0.0321
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0371
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0521 0.2745
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0131 0.0131
Onchocerca volvulus 0.0062 0.1856 0.2005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0317 0.0291
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0044 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1898 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.1856 0.1856
Brugia malayi hypothetical protein 0.0042 0.1184 0.1184
Brugia malayi Smad1 0.0009 0.0077 0.0077
Loa Loa (eye worm) melatonin receptor type 1A 0.0008 0.0023 0.0023
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.004 0.1112 0.1112
Echinococcus multilocularis serine:threonine protein kinase N2 0.0008 0.0038 0.0015
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0017 0.0317 0.1564
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.4498 0.4498
Brugia malayi Membrane calcium atpase protein 3 0.0013 0.0205 0.0205
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.4498 0.4498
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0317 0.0317
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0017 0.0317 0.0295
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0008 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0521 0.2652
Brugia malayi hypothetical protein 0.0008 0.0023 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0009 0.0044 0.0105
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0044 0.0021
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0008 0.0038 0.0038
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0336 0.1665
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0317 0.0291
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0038 0.1064 0.1044
Onchocerca volvulus 0.0035 0.094 0.1003
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0317 0.0295
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0521 0.0499
Schistosoma mansoni hypothetical protein 0.0035 0.0962 0.0958
Leishmania major calcium motive p-type ATPase, putative 0.0013 0.0205 0.0517
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0278 0.9221 0.9221
Brugia malayi hypothetical protein 0.0062 0.1856 0.1856
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0317 0.0291
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0997 0.0976
Echinococcus multilocularis serine:threonine protein kinase N2 0.0008 0.0038 0.0015
Trichomonas vaginalis glutaminase, putative 0.0296 0.9825 1
Brugia malayi GnHR receptor homolog 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0997 0.0997
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0317 0.0317
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0019 0.0418 0.0418
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0008 0.0038 0.0015
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0008 0.0024 0.0127
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0023 0.0023
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0017 0.0317 0.142
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0281 0.0263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0317 0.0291
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.1591 0.16
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0038 0.0006
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0317 0.0295
Entamoeba histolytica hypothetical protein 0.0042 0.1184 1
Echinococcus multilocularis smad 0.0009 0.0077 0.0055
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0042 0.1189 0.1189
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0997 0.0976
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0017 0.0317 0.0291
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1898 1
Loa Loa (eye worm) TYRA-2 protein 0.0008 0.0023 0.0023
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0013 0.0205 0.1104
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0521 0.0521
Echinococcus multilocularis follistatin 0.0042 0.1189 0.1169
Brugia malayi MH1 domain containing protein 0.0009 0.0077 0.0077
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0336 0.0314
Echinococcus multilocularis serine threonine protein kinase 0.0048 0.139 0.137
Trypanosoma brucei P-type H+-ATPase, putative 0.0011 0.0112 0.0471
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0317 0.0291
Brugia malayi MH1 domain containing protein 0.0009 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0044 0.0012
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0371
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0521 0.2652
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0336 0.032
Plasmodium vivax P-type ATPase4, putative 0.0028 0.0711 0.7437
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0077 0.0055
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0521 0.2652
Entamoeba histolytica protein kinase, putative 0.0008 0.0038 0.0322
Trypanosoma cruzi cysteine peptidase, putative 0.0009 0.0044 0.0231
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0521 0.4401
Loa Loa (eye worm) Smad1 0.0009 0.0077 0.0077
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0521 0.0521
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0317 0.2675
Loa Loa (eye worm) hypothetical protein 0.0077 0.2364 0.2364
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0025 0.0598 0.0587
Brugia malayi Cathepsin L-like precursor 0.0017 0.0317 0.0317
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0042 0.1189 0.6407
Toxoplasma gondii cathepsin CPL 0.0017 0.0317 0.1706
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Brugia malayi G-protein coupled receptor 0.0008 0.0023 0.0023
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0018 0.0352 0.1856
Echinococcus granulosus cathepsin l1 0.0017 0.0317 0.0295
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0371
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0962 0.0962
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0042 0.1189 0.1189
Trypanosoma cruzi MFS transporter, putative 0.0062 0.1856 0.978
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0025 0.0598 0.0598
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Schistosoma mansoni glutaminase 0.0296 0.9825 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0317 0.0317
Echinococcus granulosus smad 0.0009 0.0077 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1898 1
Loa Loa (eye worm) glutaminase 2 0.0296 0.9825 0.9825
Schistosoma mansoni hypothetical protein 0.0205 0.6727 0.684
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0521 0.0499
Echinococcus granulosus Na:K ATPase alpha subunit 0.0013 0.0205 0.0182
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0997 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0038 0.0038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0521 0.2745
Onchocerca volvulus Putative organic anion transporter 0.0062 0.1856 0.2005
Brugia malayi Cathepsin L-like precursor 0.0017 0.0317 0.0317
Echinococcus granulosus dna polymerase kappa 0.0023 0.0521 0.0499
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.0044 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0317 0.0291
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0317 0.0291
Onchocerca volvulus 0.0042 0.1189 0.1275
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0371
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0028 0.0711 0.0689
Loa Loa (eye worm) hypothetical protein 0.0062 0.1856 0.1856
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0008 0.0023 0.0023
Echinococcus multilocularis protein kinase c epsilon type 0.0015 0.0281 0.0258
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Echinococcus multilocularis expressed protein 0.0042 0.1189 0.1169
Echinococcus granulosus jun protein 0.0081 0.2525 0.2508
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0077 0.0055
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0205 0.0176
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0013 0.0205 0.0182
Trypanosoma brucei rac serine-threonine kinase, putative 0.0008 0.0038 0.0074
Brugia malayi glutaminase DH11.1 0.0296 0.9825 0.9825
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0017 0.0317 0.0186
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0013 0.0205 0.0186
Loa Loa (eye worm) hypothetical protein 0.0035 0.0962 0.0962
Schistosoma mansoni smad1 5 8 and 0.0009 0.0077 0.0056
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0521 0.2652
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.1439 0.7582
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0009 0.0044 0.0105
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0521 0.0499
Leishmania major cathepsin L-like protease 0.0017 0.0317 0.1144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1898 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0044 0.0021
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0017 0.0317 0.171
Brugia malayi Cathepsin L-like precursor 0.0017 0.0317 0.0317
Echinococcus granulosus agrin 0.0042 0.1189 0.1169
Brugia malayi putative neuropeptide receptor 0.0008 0.0023 0.0023
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0371
Brugia malayi sulfakinin receptor protein 0.0008 0.0023 0.0023
Brugia malayi hypothetical protein 0.0008 0.0023 0.0023
Leishmania major cathepsin L-like protease 0.0017 0.0317 0.1144
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.2364 0.2364
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0317 0.0291
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0028 0.0711 0.0689
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0997 0.0976
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0011 0.0137 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0008 0.0023 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1898 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Brugia malayi hypothetical protein 0.0008 0.0023 0.0023
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0013 0.0205 0.0182
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0336 0.0336
Brugia malayi ORL1-like opioid receptor 0.0008 0.0023 0.0023
Echinococcus granulosus protein kinase C gamma type 0.0048 0.139 0.137
Trypanosoma cruzi P-type H+-ATPase, putative 0.0011 0.0112 0.0593
Loa Loa (eye worm) hypothetical protein 0.0044 0.1265 0.1265
Brugia malayi hypothetical protein 0.0064 0.193 0.193
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Giardia lamblia DINP protein human, muc B family 0.0023 0.0521 0.3993
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0317 0.0295
Brugia malayi G protein-coupled receptor F59B2.13 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Leishmania major cathepsin L-like protease 0.0063 0.1898 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.094 0.092
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0044 0.0371
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.094 0.092
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.8025 0.8025
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0962 0.0962
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0371
Schistosoma mansoni Smad4 0.0009 0.0077 0.0056
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0336 0.326
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0038 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.094 0.0936
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0317 0.0291
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0038 0.0006
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0017 0.0317 0.1147
Echinococcus granulosus cathepsin l1 0.0011 0.0131 0.0108
Loa Loa (eye worm) glutaminase 0.0296 0.9825 0.9825
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.094 0.092
Brugia malayi hypothetical protein 0.0062 0.1856 0.1856
Loa Loa (eye worm) calcium ATPase 0.0009 0.0071 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.094 0.0936
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0038 0.0006
Leishmania major calcium-translocating P-type ATPase 0.0028 0.0711 0.3351
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0062 0.1856 0.1856
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0038 0.0006
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0897 0.0876
Trichomonas vaginalis cation-transporting ATPase, putative 0.0028 0.0711 0.0693
Entamoeba histolytica cysteine protease, putative 0.0017 0.0317 0.2675
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0521 0.2652
Loa Loa (eye worm) E1-E2 ATPase 0.0011 0.0112 0.0112
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0044 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0038 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0283 0.1381
Echinococcus granulosus NDR protein kinase 0.0008 0.0038 0.0015
Brugia malayi E1-E2 ATPase family protein 0.0011 0.0112 0.0112
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0025 0.0598 0.0587
Echinococcus multilocularis GPCR, family 2 0.0035 0.0962 0.0941
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0013 0.0205 0.0182
Loa Loa (eye worm) hypothetical protein 0.0042 0.1189 0.1189
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0317 0.0295
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0028 0.0711 0.0689
Onchocerca volvulus 0.0017 0.0317 0.0321
Loa Loa (eye worm) zinc finger protein 0.0301 1 1
Schistosoma mansoni ATPase 0.0028 0.0711 0.0702
Loa Loa (eye worm) cysteine protease 0.0017 0.0317 0.0317
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0521 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0008 0.0023 0.0023
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0131 0.011
Entamoeba histolytica cysteine proteinase 1, putative 0.0009 0.0044 0.0371
Brugia malayi p70 ribosomal S6 kinase beta 0.0008 0.0038 0.0038
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0038 0.0006
Brugia malayi isocitrate dehydrogenase 0.0017 0.0336 0.0336
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0317 0.4092
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0013 0.0205 0.0186
Echinococcus multilocularis protein kinase c iota type 0.0014 0.0239 0.0217
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0336 0.1811
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0521 0.0521
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0008 0.0023 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.094 0.0936
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0317 0.0295
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0997 0.0976
Echinococcus granulosus protein kinase c iota type 0.0014 0.0239 0.0217
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0062 0.1856 0.1837
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0013 0.0205 0.0182
Brugia malayi Protein kinase domain containing protein 0.0008 0.0038 0.0038
Trichomonas vaginalis AGC family protein kinase 0.0008 0.0038 0.0006
Brugia malayi sodium-independent organic anion transporter family protein 0.0062 0.1856 0.1856
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0317 0.0291
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0521 0.2745
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0997 0.0976
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0997 0.0976
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0038 0.0016
Echinococcus granulosus cysteine protease 0.0009 0.0044 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0317 0.0291
Echinococcus granulosus follistatin 0.0042 0.1189 0.1169
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.1898 1
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0317 0.0321
Schistosoma mansoni hypothetical protein 0.0035 0.0962 0.0958
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0317 0.0291
Loa Loa (eye worm) hypothetical protein 0.0017 0.0317 0.0317
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0017 0.0317 0.268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0131 0.0101
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0317 0.03
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0008 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0317 0.0291
Schistosoma mansoni hypothetical protein 0.0035 0.0962 0.0958
Echinococcus granulosus Smad4 0.0009 0.0077 0.0055
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0336 0.1771
Brugia malayi bZIP transcription factor family protein 0.0081 0.2525 0.2525
Entamoeba histolytica cysteine protease, putative 0.0009 0.0044 0.0371
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0017 0.0317 0.1672
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0317 0.0321
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0009 0.0044 0.0231
Entamoeba histolytica protein kinase, putative 0.0008 0.0038 0.0322
Schistosoma mansoni DNA polymerase eta 0.0023 0.0521 0.0508
Loa Loa (eye worm) hypothetical protein 0.0017 0.0317 0.0317
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0317 0.0317
Echinococcus granulosus calcium transporting atpase 0.0025 0.0598 0.0577
Mycobacterium ulcerans glutaminase 0.0296 0.9825 1
Brugia malayi Protein kinase domain containing protein 0.0008 0.0038 0.0038
Entamoeba histolytica hypothetical protein 0.0042 0.1184 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0062 0.1856 0.1856
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0009 0.0071 0.0603
Schistosoma mansoni smad 0.0009 0.0077 0.0056
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0013 0.0205 0.0182
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0521 0.2745
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0131 0.0101
Plasmodium vivax SET domain protein, putative 0.0035 0.094 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1898 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.094 0.094
Schistosoma mansoni hypothetical protein 0.0066 0.2006 0.2023
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0054 0.1591 0.1572
Brugia malayi putative neuropeptide receptor NPR1 0.0008 0.0023 0.0023
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0008 0.0023 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.094 0.0936
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0521 0.0397
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1898 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0011 0.0112 0.0082
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0008 0.0038 0.0015
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0317 0.2675
Brugia malayi Cathepsin L-like precursor 0.0011 0.0131 0.0131
Echinococcus granulosus dna polymerase eta 0.0023 0.0521 0.0499

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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