Detailed information for compound 1452946

Basic information

Technical information
  • TDR Targets ID: 1452946
  • Name: AK-918/40893831
  • MW: 388.459 | Formula: C24H24N2O3
  • H donors: 1 H acceptors: 3 LogP: 4.02 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(c2cccc(c2)C(=O)Nc2cccc(c2C)C)C(=O)C2C1C1CCC2C1
  • InChi: 1S/C24H24N2O3/c1-13-5-3-8-19(14(13)2)25-22(27)17-6-4-7-18(12-17)26-23(28)20-15-9-10-16(11-15)21(20)24(26)29/h3-8,12,15-16,20-21H,9-11H2,1-2H3,(H,25,27)
  • InChiKey: TUISNXSOMPQHHD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,3-dimethylphenyl)-3-(3,5-dioxo-4-azatricyclo[5.2.1.0~2,6~]dec-4-yl)benzamide
  • STK252765
  • MLS000546083
  • SMR000164208

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.1446 0.2538
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0017 0.0022
Loa Loa (eye worm) hypothetical protein 0.0147 0.2008 0.285
Brugia malayi Thioredoxin family protein 0.0279 0.3946 0.5605
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.4099 1
Brugia malayi hypothetical protein 0.0019 0.0141 0.02
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0387 0.0936
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1867 0.2649
Echinococcus multilocularis geminin 0.0337 0.479 0.6802
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.3227 0.567
Loa Loa (eye worm) hypothetical protein 0.0028 0.0269 0.0379
Brugia malayi nuclear hormone receptor 0.0011 0.0017 0.0024
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0085 0.0118
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0387 0.0674
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2887 0.4099
Schistosoma mansoni ferritin 0.001 0.0009 0.0009
Schistosoma mansoni smad1 5 8 and 0.0016 0.0098 0.0166
Schistosoma mansoni lipoxygenase 0.0019 0.0141 0.0241
Toxoplasma gondii aldehyde dehydrogenase 0.0128 0.1731 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0301 0.0425
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.001 0.0004 0.0003
Schistosoma mansoni cpg binding protein 0.0028 0.0268 0.0466
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0017 0.0024
Brugia malayi G-protein alpha subunit 0.001 0.0004 0.0005
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0098 0.0137
Echinococcus granulosus lamin 0.0028 0.0269 0.0379
Echinococcus granulosus muscleblind protein 0.0147 0.2008 0.285
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.001 0.0004 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0301 0.0523
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0188 0.0265
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0098 0.0137
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.1446 0.2052
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0217 0.1121
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.193 0.1923
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.4099 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0188 0.1148
Mycobacterium ulcerans hypothetical protein 0.0279 0.3946 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0098 0.0137
Onchocerca volvulus 0.003 0.0301 0.033
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.4099 1
Echinococcus multilocularis cpg binding protein 0.003 0.0292 0.0412
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0017 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0017 0.0024
Loa Loa (eye worm) G protein alpha subunit 3 0.001 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0003
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0108 0.1446 0.3522
Brugia malayi Doublecortin family protein 0.0019 0.0141 0.02
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0017 0.0024
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0301 0.0425
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0085 0.0347
Echinococcus multilocularis inositol monophosphatase 0.0011 0.0025 0.0034
Schistosoma mansoni hypothetical protein 0.0337 0.479 0.842
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0301 0.0425
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0003
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0098 0.0137
Mycobacterium leprae Probable lipase LipE 0.0108 0.1446 0.365
Brugia malayi MH2 domain containing protein 0.0016 0.0098 0.0139
Schistosoma mansoni pap-inositol-14-phosphatase 0.0011 0.0025 0.0038
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0077 0.0361
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.1446 0.2052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0017 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0022
Brugia malayi Inositol monophosphatase family protein 0.0011 0.0025 0.0036
Mycobacterium ulcerans putative transglutaminase-like protein 0.0279 0.3946 1
Echinococcus multilocularis smad 0.0016 0.0098 0.0137
Schistosoma mansoni ferritin 0.001 0.0009 0.0009
Schistosoma mansoni ferritin 0.001 0.0009 0.0009
Echinococcus granulosus Smad4 0.0016 0.0098 0.0137
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0085 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0017 0.0024
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.4099 1
Echinococcus granulosus tumor protein p63 0.0329 0.4683 0.665
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0108 0.1446 0.8326
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0108 0.1446 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0085 0.0417
Mycobacterium leprae Conserved hypothetical protein 0.0279 0.3946 1
Echinococcus granulosus survival motor neuron protein 1 0.049 0.7041 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0017 0.0024
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0141 0.0197
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0466 0.2804
Schistosoma mansoni rab6-interacting 0.0019 0.0141 0.0241
Schistosoma mansoni Smad4 0.0016 0.0098 0.0166
Echinococcus granulosus expressed protein 0.001 0.0004 0.0003
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.001 0.0004 0.0005
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.193 0.4879
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0078 0.0111
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0011 0.0025 0.0034
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0085 0.0118
Echinococcus multilocularis Smad4 0.0016 0.0098 0.0137
Echinococcus multilocularis inositol monophosphatase 1 0.0108 0.1446 0.2052
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0017 0.0024
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0057 0.0078
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0017 0.0024
Echinococcus granulosus dnaJ subfamily B 0.0398 0.5688 0.8077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0017 0.0022
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0188 0.0268
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0466 0.113
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.1446 0.1439
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0019 0.0025
Loa Loa (eye worm) hypothetical protein 0.0108 0.1446 0.2052
Loa Loa (eye worm) hypothetical protein 0.0036 0.0387 0.0547
Echinococcus multilocularis tumor protein p63 0.0329 0.4683 0.665
Chlamydia trachomatis 3'(2'),5'-bisphosphate nucleotidase CysQ 0.0011 0.0025 0.5
Entamoeba histolytica hypothetical protein 0.0035 0.0375 0.0906
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0375 0.053
Schistosoma mansoni ap endonuclease 0.0022 0.0188 0.0325
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0017 0.0022
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.5688 0.8077
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0743 0.1301
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0301 0.0523
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0375 0.0652
Echinococcus granulosus inositol monophosphatase 1 0.0108 0.1446 0.2052
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0077 0.0107
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0022
Echinococcus granulosus ferritin 0.001 0.0009 0.0011
Brugia malayi hypothetical protein 0.0024 0.0217 0.0308
Leishmania major hypothetical protein, conserved 0.0108 0.1446 0.8329
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.0011 0.0025 0.0041
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.001 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0022
Brugia malayi MH2 domain containing protein 0.0239 0.3366 0.478
Giardia lamblia Transglutaminase/protease, putative 0.0279 0.3946 0.9626
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.001 0.0004 0.0005
Schistosoma mansoni polycystin 1-related 0.0019 0.0141 0.0241
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.4099 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.1731 0.4374
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0701 0.396
Loa Loa (eye worm) hypothetical protein 0.0013 0.0057 0.0078
Brugia malayi Cytochrome P450 family protein 0.0015 0.0077 0.0109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.3227 0.567
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0004 0.0003
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0077 0.0107
Brugia malayi Pre-SET motif family protein 0.0207 0.2887 0.41
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0416 1
Onchocerca volvulus 0.0108 0.1446 0.1602
Schistosoma mansoni apoferritin-2 0.001 0.0009 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.4099 1
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0017 0.0022
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.001 0.0004 0.0005
Schistosoma mansoni ferritin light chain 0.001 0.0009 0.0009
Echinococcus granulosus geminin 0.0337 0.479 0.6802
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0387 0.0547
Mycobacterium leprae Probable monophosphatase 0.0011 0.0025 0.0041
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.1731 0.3039
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0387 0.2545
Loa Loa (eye worm) hypothetical protein 0.0027 0.0261 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0387 0.0936
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0004 0.0003
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0387 0.0547
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0301 0.0523
Onchocerca volvulus 0.0011 0.0017 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.1446 0.3523
Mycobacterium tuberculosis Monophosphatase CysQ 0.0011 0.0025 0.0016
Loa Loa (eye worm) Smad1 0.0016 0.0098 0.0137
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0108 0.1446 0.3522
Loa Loa (eye worm) beta-lactamase 0.0108 0.1446 0.2052
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0077 0.0361
Leishmania major cytochrome p450-like protein 0.0015 0.0077 0.0301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.4099 1
Schistosoma mansoni rab6-interacting 0.0019 0.0141 0.0241
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0011 0.0025 0.0034
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0217 0.1346
Schistosoma mansoni survival motor neuron protein 0.01 0.1324 0.2323
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0017 0.0015
Mycobacterium tuberculosis Probable monophosphatase 0.0011 0.0025 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.023 0.3227 0.4581
Plasmodium vivax hypothetical protein, conserved 0.0108 0.1446 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0301 0.0523
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0085 0.0417
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0017 0.0022
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0004 0.0003
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0387 0.0936
Schistosoma mansoni lipoxygenase 0.0054 0.0647 0.1132
Brugia malayi hypothetical protein 0.0016 0.009 0.0128
Mycobacterium ulcerans beta-lactamase 0.0108 0.1446 0.365
Echinococcus granulosus smad 0.0016 0.0098 0.0137
Mycobacterium ulcerans transglutaminase family protein 0.0279 0.3946 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0188 0.0265
Brugia malayi MH2 domain containing protein 0.0016 0.0098 0.0139
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.4099 1
Mycobacterium tuberculosis Long conserved protein 0.0279 0.3946 0.3941
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0128 0.1731 0.2457
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0269 0.0379
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0017 0.0022
Onchocerca volvulus 0.0235 0.3304 0.3665
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.023 0.3227 0.4581
Brugia malayi Kringle domain containing protein 0.0017 0.0115 0.0163
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0085 0.0118
Trichomonas vaginalis ferritin, putative 0.001 0.0009 0.0013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0188 0.1148
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0108 0.1446 0.2052
Schistosoma mansoni hypothetical protein 0.0011 0.0019 0.0028
Schistosoma mansoni smad1 5 8 and 0.0016 0.0098 0.0166
Trichomonas vaginalis inositol monophosphatase, putative 0.0108 0.1446 0.3522
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0017 0.0115 0.022
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0011 0.0025 0.0053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0217 0.0305
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0017 0.0024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.023 0.3227 0.4581
Schistosoma mansoni lamin 0.0028 0.0269 0.0466
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0128 0.1731 0.2457
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0097 0.128 0.1272
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0004 0.0003
Echinococcus granulosus Transglutaminase 0.0279 0.3946 0.5604
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.3227 0.567
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0387 0.0547
Toxoplasma gondii ABC1 family protein 0.0108 0.1446 0.8329
Schistosoma mansoni coup transcription factor 0.0011 0.0017 0.0024
Entamoeba histolytica hypothetical protein 0.0035 0.0375 0.0906
Mycobacterium tuberculosis Conserved hypothetical protein 0.0279 0.3946 0.3941
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.001 0.0004 0.0005
Echinococcus multilocularis expressed protein 0.001 0.0009 0.0011
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0077 0.0172
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0085 0.0347
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0387 0.0674
Brugia malayi Pre-SET motif family protein 0.003 0.0301 0.0428
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0017 0.0024
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0017 0.0022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0017 0.0024
Echinococcus multilocularis RUN 0.0019 0.0141 0.0197
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.1446 0.2538
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0387 0.2545
Echinococcus multilocularis expressed protein 0.001 0.0004 0.0003
Entamoeba histolytica hypothetical protein 0.0035 0.0375 0.0906
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0466 0.2586
Echinococcus granulosus tissue type plasminogen activator 0.0017 0.0115 0.016
Mycobacterium tuberculosis Conserved protein 0.0279 0.3946 0.3941
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0017 0.0024
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0387 0.0547
Echinococcus multilocularis musashi 0.0028 0.0269 0.0379
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0022
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0085 0.0417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0017 0.0022
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0188 0.0451
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0085 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0017 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0017 0.0024
Loa Loa (eye worm) acetyltransferase 0.0141 0.1925 0.2731
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0098 0.0166
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0097 0.128 0.3227
Leishmania major hypothetical protein, conserved 0.0024 0.0217 0.1121
Schistosoma mansoni cpg binding protein 0.003 0.0292 0.0507
Trichomonas vaginalis set domain proteins, putative 0.0235 0.3304 0.8059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0017 0.0022
Schistosoma mansoni loxhd1 0.0019 0.0141 0.0241
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0387 0.212
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0018
Onchocerca volvulus 0.0625 0.9008 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0188 0.1148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0017 0.0022
Brugia malayi steroid hormone receptor 0.0011 0.0017 0.0024
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0188 0.0456
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0022
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0108 0.1446 0.2052
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0004 0.0005
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0085 0.012
Schistosoma mansoni smad1 5 8 and 0.0016 0.0098 0.0166
Loa Loa (eye worm) inositol-1 0.0108 0.1446 0.2052
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0141 0.0197
Schistosoma mansoni ferritin 0.001 0.0009 0.0009
Schistosoma mansoni apoferritin-2 0.001 0.0009 0.0009
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0217 0.097
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0141 0.0411
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0269 0.0381
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0078 0.0109
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0108 0.1446 0.3649
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0017 0.0022
Mycobacterium ulcerans hypothetical protein 0.0108 0.1446 0.365
Onchocerca volvulus 0.0028 0.0268 0.0294
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.1446 0.1439
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0197
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0108 0.1446 0.9997
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0004 0.0003
Schistosoma mansoni ferritin light chain 0.001 0.0009 0.0009
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.4099 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0017 0.0015
Brugia malayi hypothetical protein 0.0019 0.0141 0.02
Echinococcus granulosus intermediate filament protein 0.0028 0.0269 0.0379
Schistosoma mansoni hypothetical protein 0.0398 0.5688 1
Mycobacterium ulcerans hypothetical protein 0.0279 0.3946 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0387 0.0936
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0647 0.0917
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0466 0.2586
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0085 0.0417
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0387 0.0888
Brugia malayi CXXC zinc finger family protein 0.0028 0.0268 0.0381
Schistosoma mansoni intermediate filament proteins 0.0028 0.0269 0.0466
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0077 0.0361
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.193 0.4879
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.4099 1
Brugia malayi Cytochrome P450 family protein 0.0015 0.0077 0.0109
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0017 0.0022
Schistosoma mansoni lamin 0.0028 0.0269 0.0466
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0085 0.0347
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0017 0.0024
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0017 0.0024
Mycobacterium ulcerans monophosphatase CysQ 0.0011 0.0025 0.0041
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0085 0.0118
Brugia malayi ecdysteroid receptor 0.0011 0.0017 0.0024
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.1446 0.365
Schistosoma mansoni smad 0.0016 0.0098 0.0166
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.4099 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0301 0.0425
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0011 0.0025 0.0053
Schistosoma mansoni inositol monophosphatase 0.0108 0.1446 0.2537
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0034
Leishmania major hypothetical protein, conserved 0.0017 0.0115 0.0523
Loa Loa (eye worm) TK/ROR protein kinase 0.0017 0.0115 0.016
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.1446 0.1439
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.1446 0.3523
Brugia malayi nuclear receptor NHR-88 0.0011 0.0017 0.0024
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.1446 0.1439
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0017 0.0022
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.1446 0.365
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.1446 0.1439
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0416 0.0959
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0387 0.055
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0017 0.0022
Onchocerca volvulus 0.0108 0.1446 0.1602
Echinococcus multilocularis ferritin 0.001 0.0009 0.0011
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0387 0.0547
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0197
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0301 0.1616
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0017 0.0024
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0276 0.039
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0017 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0115 0.0628
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0085 0.0118
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0217 0.1346
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0085 0.0118
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0017 0.0024
Plasmodium falciparum cysteine repeat modular protein 1 0.0017 0.0115 0.0905
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0004 0.0003
Onchocerca volvulus 0.0028 0.0269 0.0294
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0128 0.1731 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.023 0.3227 0.4583
Trichomonas vaginalis peptide N-glycanase, putative 0.0279 0.3946 0.9628
Brugia malayi Smad1 0.0016 0.0098 0.0139
Schistosoma mansoni hypothetical protein 0.0011 0.0025 0.0038
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0565 0.0988
Schistosoma mansoni cpg binding protein 0.003 0.0292 0.0507
Mycobacterium ulcerans monophosphatase 0.0011 0.0025 0.0041
Toxoplasma gondii exonuclease III APE 0.0022 0.0188 0.0956
Echinococcus granulosus cpg binding protein 0.003 0.0292 0.0412
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.1446 0.3523
Mycobacterium tuberculosis Conserved protein 0.0108 0.1446 0.1439
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0188 0.3134
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0011 0.0025 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.1731 0.3039
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.1446 0.2052
Mycobacterium tuberculosis Conserved protein 0.0108 0.1446 0.1439
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.049 0.7041 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0017 0.0024
Echinococcus multilocularis muscleblind protein 1 0.0147 0.2008 0.285
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0188 0.0451
Brugia malayi MH1 domain containing protein 0.0016 0.0098 0.0139
Mycobacterium tuberculosis Conserved protein 0.0108 0.1446 0.1439
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.1446 0.1439
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.1446 0.3523
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0004 0.0005
Onchocerca volvulus 0.0028 0.0269 0.0294
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0077 0.0107
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.3366 0.4779
Brugia malayi Muscleblind-like protein 0.0147 0.2008 0.2851
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1925 0.2731
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0057 0.0078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.023 0.3227 0.4581
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.1446 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0022
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0017 0.0024
Giardia lamblia Hypothetical protein 0.0279 0.3946 0.9626
Echinococcus granulosus inositol monophosphatase 0.0011 0.0025 0.0034
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0188 0.1248
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0188 0.018
Brugia malayi isocitrate dehydrogenase 0.0015 0.0085 0.012
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.001 0.0004 0.0003
Echinococcus granulosus RUN 0.0019 0.0141 0.0197
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0375 0.053
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.1446 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0141 0.0197
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0387 0.2545
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0269 0.0379
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0017 0.0024
Brugia malayi hypothetical protein 0.001 0.0004 0.0005
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0017 0.0024
Plasmodium vivax SET domain protein, putative 0.003 0.0301 0.1589
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0017 0.0022
Mycobacterium leprae Conserved hypothetical protein 0.0279 0.3946 1
Schistosoma mansoni hypothetical protein 0.0017 0.0115 0.0195
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0268 0.0379
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0141 0.0197
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.001 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.01 0.1324 0.2323
Schistosoma mansoni hypothetical protein 0.0011 0.0025 0.0038
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0188 0.0762
Mycobacterium tuberculosis Conserved hypothetical protein 0.0279 0.3946 0.3941
Onchocerca volvulus 0.0108 0.1446 0.1602
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0022
Loa Loa (eye worm) hypothetical protein 0.0108 0.1446 0.2052
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0188 0.0439
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0141 0.0197
Echinococcus multilocularis muscleblind protein 0.0147 0.2008 0.285
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.4099 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0011 0.0025 0.0053
Entamoeba histolytica hypothetical protein 0.0035 0.0375 0.0906
Loa Loa (eye worm) hypothetical protein 0.0147 0.2008 0.285
Echinococcus multilocularis lamin dm0 0.0028 0.0269 0.0379
Brugia malayi Inositol monophosphatase family protein 0.0011 0.0025 0.0036
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0004 0.0005
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0004 0.0003
Echinococcus granulosus expressed protein 0.001 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0017 0.0024
Brugia malayi beta-lactamase 0.0108 0.1446 0.2054
Onchocerca volvulus 0.0019 0.0141 0.0152
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0011 0.0025 0.0053
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.3366 0.4779
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0188 0.0956
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0017 0.0024
Echinococcus multilocularis lamin 0.0028 0.0269 0.0379
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0098 0.0137
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.001 0.0004 0.0005
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.001 0.0004 0.0003
Onchocerca volvulus 0.0019 0.0141 0.0152
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0108 0.1446 0.8326
Loa Loa (eye worm) hypothetical protein 0.0108 0.1446 0.2052
Mycobacterium leprae POSSIBLE MONOPHOSPHATASE CYSQ 0.0011 0.0025 0.0041
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0108 0.1446 0.9997
Brugia malayi beta-lactamase family protein 0.0108 0.1446 0.2054
Schistosoma mansoni hypothetical protein 0.0035 0.0375 0.0652
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0416 0.1006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.1731 0.4374
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0141 0.1688
Brugia malayi Protein kinase domain containing protein 0.0017 0.0115 0.0163
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.001 0.0004 0.0003
Schistosoma mansoni myo inositol monophosphatase 0.0011 0.0025 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0017 0.0022
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0108 0.1446 0.3522
Mycobacterium ulcerans monophosphatase CysQ 0.0011 0.0025 0.0041
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.1446 0.2054
Mycobacterium leprae conserved hypothetical protein 0.0108 0.1446 0.365
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0217 0.3987
Loa Loa (eye worm) hypothetical protein 0.0017 0.0115 0.016
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0217 0.3987
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0141 0.0197
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0098 0.0137
Trichomonas vaginalis inositol monophosphatase, putative 0.0011 0.0025 0.0053
Brugia malayi Inositol-1 0.0108 0.1446 0.2053
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.1446 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0188 0.0451
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0034
Schistosoma mansoni ap endonuclease 0.0022 0.0188 0.0325
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0108 0.1446 0.9997
Echinococcus multilocularis Transglutaminase 0.0279 0.3946 0.5604
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0188 0.0265
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0017 0.0022
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0466 0.113
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0003
Brugia malayi hypothetical protein 0.0035 0.0375 0.0532
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0466 0.066
Trichomonas vaginalis esterase, putative 0.0108 0.1446 0.3523
Onchocerca volvulus 0.0017 0.0115 0.0123
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0085 0.0076
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0017 0.0015
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0011 0.0025 0.0053
Onchocerca volvulus 0.01 0.1324 0.1466
Mycobacterium tuberculosis Hypothetical protein 0.0279 0.3946 0.3941
Loa Loa (eye worm) hypothetical protein 0.0108 0.1446 0.2052
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0003
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1925 0.3379
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0017 0.0022
Schistosoma mansoni inositol monophosphatase 0.0108 0.1446 0.2537
Echinococcus granulosus lamin dm0 0.0028 0.0269 0.0379
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.023 0.3227 0.4581
Loa Loa (eye worm) hypothetical protein 0.0048 0.0565 0.08
Brugia malayi hypothetical protein 0.049 0.7041 1
Echinococcus multilocularis survival motor neuron protein 1 0.049 0.7041 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0017 0.0024
Brugia malayi intermediate filament protein 0.0028 0.0269 0.0381
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0017 0.0022
Brugia malayi beta-lactamase family protein 0.0108 0.1446 0.2054
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.1446 0.1439
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0017 0.0022
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0141 0.0197
Schistosoma mansoni hypothetical protein 0.0279 0.3946 0.6936
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0188 0.04
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1925 0.2733
Brugia malayi MH1 domain containing protein 0.0016 0.0098 0.0139
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.1731 0.4374
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0019 0.0025
Echinococcus multilocularis tissue type plasminogen activator 0.0017 0.0115 0.016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0022
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0017 0.0022
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0128 0.1731 0.1724
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0017 0.0022
Mycobacterium ulcerans lipase LipD 0.0108 0.1446 0.365
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.1324 0.188
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.1446 0.3523
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0647 0.0917
Schistosoma mansoni hypothetical protein 0.0019 0.0141 0.0241
Schistosoma mansoni hypothetical protein 0.0337 0.479 0.842
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0387 0.0547
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0017 0.0022
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0017 0.0022
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0217 0.1346
Toxoplasma gondii kringle domain-containing protein 0.0017 0.0115 0.0523
Onchocerca volvulus 0.0048 0.0565 0.0623

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 11.22018454 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 22.38721139 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 25.11886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 0.1042 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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