Detailed information for compound 1467419

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 403.419 | Formula: C17H20F3N3O3S
  • H donors: 2 H acceptors: 4 LogP: 1.69 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1cn(nc1C(F)(F)F)Cc1ccc2c(c1)C[C@H](C2)NS(=O)(=O)CC
  • InChi: 1S/C17H20F3N3O3S/c1-2-27(25,26)22-15-6-12-4-3-11(5-13(12)7-15)8-23-9-14(10-24)16(21-23)17(18,19)20/h3-5,9,15,22,24H,2,6-8,10H2,1H3/t15-/m0/s1
  • InChiKey: RRWIGUFXQVAWHG-HNNXBMFYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutamate receptor, ionotropic, AMPA 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) glutamate receptor 1 Get druggable targets OG5_128645 All targets in OG5_128645
Echinococcus granulosus glutamate receptor 4 Get druggable targets OG5_128645 All targets in OG5_128645
Echinococcus granulosus glutamate receptor 2 Get druggable targets OG5_128645 All targets in OG5_128645
Echinococcus multilocularis glutamate receptor 2 Get druggable targets OG5_128645 All targets in OG5_128645
Echinococcus granulosus glutamate receptor 2 Get druggable targets OG5_128645 All targets in OG5_128645
Echinococcus granulosus glutamate receptor subunit protein glur Get druggable targets OG5_128645 All targets in OG5_128645
Echinococcus multilocularis glutamate receptor 4 Get druggable targets OG5_128645 All targets in OG5_128645
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 Get druggable targets OG5_128645 All targets in OG5_128645
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128645 All targets in OG5_128645
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128645 All targets in OG5_128645
Echinococcus multilocularis glutamate receptor 2 Get druggable targets OG5_128645 All targets in OG5_128645
Brugia malayi Glutamate receptor 2 precursor Get druggable targets OG5_128645 All targets in OG5_128645
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 Get druggable targets OG5_128645 All targets in OG5_128645
Echinococcus multilocularis glutamate receptor 2 Get druggable targets OG5_128645 All targets in OG5_128645
Echinococcus multilocularis glutamate receptor subunit protein glur Get druggable targets OG5_128645 All targets in OG5_128645
Echinococcus granulosus glutamate receptor 1 Get druggable targets OG5_128645 All targets in OG5_128645
Brugia malayi Glutamate receptor 1 precursor Get druggable targets OG5_128645 All targets in OG5_128645
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128645 All targets in OG5_128645
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 glutamate receptor, ionotropic, AMPA 2 883 aa 810 aa 34.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cytochrome P450 family protein 0.011 0.0065 0.0826
Schistosoma mansoni nuclear hormone receptor 0.002 0.0002 0.0004
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0363 0.0243 0.3162
Leishmania major phosphatidylinositol 3-kinase, putative 0.1057 0.073 0.1982
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1107 0.0765 0.2168
Echinococcus multilocularis glutamate receptor 2 0.0087 0.0049 0.0047
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0062 0.3884
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0008 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.4979 0.3484 1
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0008 0.003
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0015 0.012
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0012 0.0083
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0008 0.5
Plasmodium vivax hypothetical protein, conserved 0.0215 0.0139 0.7966
Onchocerca volvulus 0.0029 0.0008 0.0406
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0266 0.0175 0.0448
Schistosoma mansoni thyroid hormone receptor 0.002 0.0002 0.0004
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0215 0.0139 0.1876
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0076 0.1011
Leishmania major phosphatidylinositol kinase related protein, putative 0.023 0.015 0.0378
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0266 0.0175 0.2246
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0052 0.0025 0.2462
Trichomonas vaginalis PIKK family atypical protein kinase 0.1075 0.0743 0.9893
Echinococcus granulosus glutamate receptor 2 0.0087 0.0049 0.0047
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0015 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.1057 0.073 0.9722
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0266 0.0175 0.2326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0621 0.0424 0.5612
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0301 0.02 0.2654
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0266 0.0175 0.2355
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0329 0.0219 0.2865
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1107 0.0765 0.0763
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0015 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0002 0.0029
Echinococcus granulosus serine protein kinase ATM 0.0617 0.0422 0.0419
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0025 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0215 0.0139 0.1792
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1057 0.073 0.9719
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0062 0.3884
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0329 0.0219 0.2843
Trichomonas vaginalis PIKK family atypical protein kinase 0.1069 0.0738 0.9829
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0036 0.0013 0.0011
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0087 0.0049 0.0047
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0002 0.0029
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1087 0.0751 1
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0008 0.003
Echinococcus multilocularis muscleblind protein 1 0.0301 0.02 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.1068 0.0738 0.9822
Brugia malayi 6-phosphofructokinase 0.0105 0.0062 0.0779
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0426 0.0287 0.0285
Brugia malayi phosphofructokinase 0.0105 0.0062 0.0779
Plasmodium vivax hypothetical protein 0.0215 0.0139 0.7966
Entamoeba histolytica hypothetical protein 0.0215 0.0139 0.1767
Echinococcus multilocularis glutamate receptor 2 0.0081 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0051 0.0024 0.0316
Schistosoma mansoni coup transcription factor 0.002 0.0002 0.0004
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0062 0.0724
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0266 0.0175 0.0468
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1087 0.0751 0.2039
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0015 0.012
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0015 0.012
Echinococcus multilocularis 0.0215 0.0139 0.0137
Entamoeba histolytica hypothetical protein 0.0617 0.0422 0.5564
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1087 0.0751 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0215 0.0139 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0617 0.0422 0.5495
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0215 0.0139 0.1767
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0062 0.0724
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0215 0.0139 0.1795
Loa Loa (eye worm) hypothetical protein 0.0455 0.0307 0.4088
Loa Loa (eye worm) hypothetical protein 0.0301 0.02 0.2654
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0266 0.0175 0.2265
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1087 0.0751 0.0749
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0774 0.0532 0.6937
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0062 0.082
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0266 0.0175 0.0468
Trichomonas vaginalis PIKK family atypical protein kinase 0.1066 0.0737 0.9807
Schistosoma mansoni alpha-glucosidase 0.0147 0.0092 0.1171
Loa Loa (eye worm) hypothetical protein 0.0402 0.027 0.3595
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0087 0.0049 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.1066 0.0737 0.9807
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0008 0.0455
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0025 0.0328
Echinococcus granulosus cytochrome P450 2K1 0.0035 0.0013 0.001
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0426 0.0287 0.0285
Loa Loa (eye worm) hypothetical protein 0.0127 0.0077 0.1025
Echinococcus granulosus glutamate receptor 4 0.0051 0.0024 0.0022
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.4261 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0215 0.0139 0.1717
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0002 0.0029
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0062 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0008 0.0455
Trichomonas vaginalis PIKK family atypical protein kinase 0.1075 0.0743 0.9893
Trichomonas vaginalis PIKK family atypical protein kinase 0.1066 0.0737 0.9808
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0015 0.012
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0215 0.0139 0.1799
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0008 0.0082
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0036 0.0013 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0002 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0002 0.0029
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0329 0.0219 0.2843
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1087 0.0751 1
Echinococcus multilocularis tumor protein p63 0.0355 0.0237 0.0235
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0002 0.0004
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0062 0.0783
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0019 0.0017
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0507 0.0344 0.4535
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0215 0.0139 0.1792
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0062 0.0752
Schistosoma mansoni hypothetical protein 0.0215 0.0139 0.1799
Schistosoma mansoni alpha-glucosidase 0.0147 0.0092 0.1171
Brugia malayi FAT domain containing protein 0.0455 0.0307 0.3995
Loa Loa (eye worm) hypothetical protein 0.0029 0.0008 0.0108
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.0108 0.1438
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0008 0.0113
Echinococcus granulosus microtubule associated protein 2 0.0725 0.0497 0.0495
Loa Loa (eye worm) phosphatidylinositol 3 0.1087 0.0751 1
Brugia malayi cytochrome P450 0.0035 0.0013 0.0133
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0062 0.0136
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0215 0.0139 0.1876
Trichomonas vaginalis PIKK family atypical protein kinase 0.1078 0.0745 0.9914
Trichomonas vaginalis PIKK family atypical protein kinase 0.1078 0.0745 0.9914
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0215 0.0139 0.1792
Echinococcus granulosus glutamate NMDA receptor subunit 0.003 0.0009 0.0007
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0266 0.0175 0.2198
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0015 0.0091
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0279 0.0184 0.2365
Trypanosoma cruzi cytochrome P450, putative 0.0052 0.0025 0.0035
Loa Loa (eye worm) phosphatidylinositol 3 0.0215 0.0139 0.1853
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0266 0.0175 0.2269
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1087 0.0751 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0002 0.0029
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.003 0.0009 0.0007
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0215 0.0139 0.0137
Schistosoma mansoni glutamate receptor kainate 0.003 0.0009 0.0096
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0604 0.0412 0.5448
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0013 0.0142
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0215 0.0139 0.1717
Trichomonas vaginalis PIKK family atypical protein kinase 0.1078 0.0745 0.9914
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1078 0.0745 0.9914
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0215 0.0139 0.1795
Giardia lamblia Phosphatidylinositol 4-kinase 0.0215 0.0139 0.1767
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0604 0.0412 0.5434
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0021 0.0241
Loa Loa (eye worm) phosphatidylinositol 3 0.0711 0.0487 0.6484
Echinococcus granulosus glutamate receptor 2 0.0076 0.0041 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.067 0.0459 0.6073
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0455 0.0307 0.0305
Brugia malayi hypothetical protein 0.0228 0.0149 0.1915
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0215 0.0139 0.0137
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0014 0.0011
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0215 0.0139 0.0365
Entamoeba histolytica hypothetical protein 0.0038 0.0015 0.0089
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0002 0.0004
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0036 0.0013 0.0011
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1087 0.0751 0.2039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0019 0.0017
Toxoplasma gondii FATC domain-containing protein 0.0617 0.0422 0.5672
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0019 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.1057 0.073 0.9722
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0215 0.0139 0.0137
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1068 0.0738 0.982
Onchocerca volvulus 0.0047 0.0021 0.1258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0002 0.0029
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0215 0.0139 0.7924
Loa Loa (eye worm) hypothetical protein 0.0051 0.0024 0.0316
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1087 0.0751 0.0749
Trichomonas vaginalis PIKK family atypical protein kinase 0.1069 0.0738 0.9829
Giardia lamblia Hypothetical protein 0.0215 0.0139 0.1767
Trichomonas vaginalis PIKK family atypical protein kinase 0.0215 0.0139 0.1792
Trichomonas vaginalis PIKK family atypical protein kinase 0.0621 0.0424 0.5612
Loa Loa (eye worm) hypothetical protein 0.002 0.0002 0.0029
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0002 0.0004
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0388 0.0261 0.3399
Loa Loa (eye worm) glutamate receptor 2 0.003 0.0009 0.0122
Loa Loa (eye worm) cytochrome P450 family protein 0.011 0.0065 0.0868
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0402 0.027 0.0742
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0215 0.0139 0.0365
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0613 0.0419 0.5527
Trichomonas vaginalis PIKK family atypical protein kinase 0.1078 0.0745 0.9914
Brugia malayi Muscleblind-like protein 0.0301 0.02 0.2584
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0015 0.0006
Schistosoma mansoni fkbp-rapamycin associated protein 0.0603 0.0411 0.5362
Entamoeba histolytica hypothetical protein 0.0038 0.0015 0.0089
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0266 0.0175 0.2265
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0062 0.082
Brugia malayi Cytochrome P450 family protein 0.0052 0.0025 0.0292
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.0129 0.1718
Brugia malayi Glutamate receptor 1 precursor 0.0081 0.0045 0.0561
Entamoeba histolytica hypothetical protein 0.0038 0.0015 0.0089
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0426 0.0287 0.3824
Schistosoma mansoni glutamate receptor AMPA 0.003 0.0009 0.0096
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0014 0.0148
Loa Loa (eye worm) hypothetical protein 0.0177 0.0113 0.1496
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0015 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0008 0.0082
Toxoplasma gondii non-specific serine/threonine protein kinase 0.067 0.0459 0.617
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0604 0.0412 0.115
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0014 0.0179
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0051 0.0024 0.0316
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0266 0.0175 1
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0062 0.0752
Schistosoma mansoni glutamate receptor NMDA 0.003 0.0009 0.0096
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0006 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0015 0.0006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0025 0.0294
Echinococcus granulosus glutamate receptor subunit protein glur 0.0062 0.0032 0.0029
Loa Loa (eye worm) hypothetical protein 0.002 0.0002 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0632 0.0432 0.5719
Echinococcus granulosus bloom syndrome protein 0.0025 0.0006 0.0003
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0329 0.0219 0.2865
Loa Loa (eye worm) CYP4Cod1 0.0052 0.0025 0.0326
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0014 0.0011
Loa Loa (eye worm) cytochrome P450 0.0035 0.0013 0.0165
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0008 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.1075 0.0743 0.9893
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0008 0.0255
Loa Loa (eye worm) hypothetical protein 0.0052 0.0025 0.0328
Schistosoma mansoni hypothetical protein 0.0035 0.0013 0.0138
Echinococcus multilocularis microtubule associated protein 2 0.0725 0.0497 0.0495
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0215 0.0139 0.1799
Brugia malayi Glutamate receptor 2 precursor 0.0081 0.0045 0.0561
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0015 0.0012
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0603 0.0411 0.1149
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0062 0.0142
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0679 0.0465 0.6124
Entamoeba histolytica protein kinase rad3, putative 0.0603 0.0411 0.5427
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0443 0.0299 0.3921
Leishmania major hypothetical protein, unknown function 0.0215 0.0139 0.035
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0025 0.0326
Loa Loa (eye worm) hypothetical protein 0.067 0.0459 0.6102
Schistosoma mansoni survival motor neuron protein 0.0047 0.0021 0.0246
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0008 0.003
Schistosoma mansoni thyroid hormone receptor 0.002 0.0002 0.0004
Trypanosoma cruzi target of rapamycin kinase 3 0.1078 0.0745 0.2109
Trichomonas vaginalis PIKK family atypical protein kinase 0.1075 0.0743 0.9893
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0411 0.5441
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0015 0.012
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0604 0.0412 0.115
Schistosoma mansoni cytochrome P450 0.0035 0.0013 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.1087 0.0751 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0266 0.0175 0.0173
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0215 0.0139 0.1876
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0015 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.1057 0.073 0.9722
Echinococcus granulosus muscleblind protein 0.0301 0.02 0.0197
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1107 0.0765 0.2168
Echinococcus multilocularis muscleblind protein 0.0301 0.02 0.0197
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0008 0.003
Loa Loa (eye worm) phosphatidylinositol 3 0.0215 0.0139 0.1853
Brugia malayi Pre-SET motif family protein 0.0201 0.0129 0.1663
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0036 0.0013 0.0011
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0266 0.0175 0.2246
Leishmania major phosphatidylinositol 3-kinase, putative 0.0266 0.0175 0.0448
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0008 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.1087 0.0751 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0266 0.0175 0.2269
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0008 0.5
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.023 0.015 0.0394
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0016 0.0183
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0455 0.0307 0.0305
Toxoplasma gondii target of rapamycin (TOR), putative 0.1075 0.0743 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0215 0.0139 0.0137
Loa Loa (eye worm) hypothetical protein 0.0228 0.0149 0.1974
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0329 0.0219 0.2799
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0603 0.0411 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0455 0.0307 0.4044
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0108 0.0106
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1068 0.0738 0.2002
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0215 0.0139 0.7966
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0604 0.0412 0.5448
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0266 0.0175 1
Schistosoma mansoni glutamate receptor kainate 0.003 0.0009 0.0096
Loa Loa (eye worm) hypothetical protein 0.0032 0.001 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.1075 0.0743 0.9893
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0604 0.0412 0.5448
Brugia malayi Cytochrome P450 family protein 0.0035 0.0013 0.0133
Schistosoma mansoni hypothetical protein 0.0455 0.0307 0.3998
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0015 0.02
Loa Loa (eye worm) hypothetical protein 0.0052 0.0025 0.0324
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0215 0.0139 0.0137
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0062 0.0724
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0002 0.0004
Loa Loa (eye worm) phosphatidylinositol 3 0.0215 0.0139 0.1853
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.017 0.0108 0.1381
Echinococcus granulosus tumor protein p63 0.0355 0.0237 0.0235
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0002 0.0004
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0507 0.0344 0.4535
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0062 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1075 0.0743 0.9893
Entamoeba histolytica hypothetical protein 0.054 0.0368 0.4837
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0617 0.0422 0.5536
Echinococcus multilocularis glutamate receptor 4 0.0051 0.0024 0.0022
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0215 0.0139 0.0365
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0076 0.1011
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1078 0.0745 0.2021
Trichomonas vaginalis PIKK family atypical protein kinase 0.1087 0.0751 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0015 0.012
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.0108 0.1387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0621 0.0424 0.5612
Echinococcus multilocularis 0.0035 0.0013 0.001
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1107 0.0765 0.0763
Brugia malayi hypothetical protein 0.0038 0.0015 0.016
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0617 0.0422 0.1178
Entamoeba histolytica hypothetical protein 0.0215 0.0139 0.1767
Trichomonas vaginalis PIKK family atypical protein kinase 0.1066 0.0737 0.9808
Onchocerca volvulus 0.0052 0.0025 0.1514
Loa Loa (eye worm) hypothetical protein 0.0215 0.0139 0.1853
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0025 0.0295
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0008 0.0006
Schistosoma mansoni glutamate receptor kainate 0.003 0.0009 0.0096
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0604 0.0412 0.5367
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0215 0.0139 0.7966
Trichomonas vaginalis PIKK family atypical protein kinase 0.0387 0.026 0.3411
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0266 0.0175 0.2269
Brugia malayi MH2 domain containing protein 0.0125 0.0076 0.0966
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0062 0.082
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0062 0.0783
Trichomonas vaginalis PIKK family atypical protein kinase 0.069 0.0473 0.6266
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0036 0.0013 0.0011
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0062 0.0667
Schistosoma mansoni glutamate receptor AMPA 0.003 0.0009 0.0096
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0019 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.1057 0.073 0.9722
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0008 0.0109
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.0108 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.1066 0.0737 0.9808
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0062 0.0059
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0617 0.0422 0.5493
Schistosoma mansoni hypothetical protein 0.0038 0.0015 0.0164
Loa Loa (eye worm) hypothetical protein 0.0603 0.0411 0.5475
Mycobacterium leprae conserved hypothetical protein 0.0215 0.0139 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0015 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0623 0.0426 0.5633
Loa Loa (eye worm) hypothetical protein 0.002 0.0002 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0019 0.0223
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0114 0.0068 0.016
Leishmania major phosphatidylinositol 4-kinase, putative 0.0215 0.0139 0.035
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0008 0.0005
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1087 0.0751 0.9814
Toxoplasma gondii cytochrome p450 superfamily protein 0.0035 0.0013 0.017
Loa Loa (eye worm) phosphatidylinositol 3 0.1068 0.0738 0.9823
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0266 0.0175 0.2355
Trichomonas vaginalis PIKK family atypical protein kinase 0.1075 0.0743 0.9893
Trypanosoma brucei glucosidase, putative 0.0038 0.0015 0.0029
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0019 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0613 0.0419 0.5541
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0329 0.0219 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.1066 0.0737 0.9807
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1087 0.0751 0.9814
Onchocerca volvulus 0.0229 0.0149 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0329 0.0219 0.2846
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0019 0.0252
Trichomonas vaginalis PIKK family atypical protein kinase 0.1078 0.0745 0.9914
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0006 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0008 0.0082
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0215 0.0139 0.0365
Schistosoma mansoni hypothetical protein 0.0036 0.0013 0.0146
Onchocerca volvulus 0.0215 0.0139 0.9358
Leishmania major phosphatidylinositol kinase, putative 0.0215 0.0139 0.035
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1087 0.0751 0.2128
Brugia malayi 6-phosphofructokinase 0.0105 0.0062 0.0779
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0062 0.0059
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0015 0.0091
Loa Loa (eye worm) RecQ helicase 0.0025 0.0006 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0617 0.0422 0.5577
Loa Loa (eye worm) hypothetical protein 0.002 0.0002 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0019 0.0223
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0015 0.012
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0036 0.0013 0.0011
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0215 0.0139 0.7924
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1107 0.0765 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0002 0.0029
Schistosoma mansoni ATP-binding cassette transporter 0.003 0.0009 0.0096
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0019 0.0219
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0266 0.0175 0.2261
Trichomonas vaginalis conserved hypothetical protein 0.0387 0.026 0.3411
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0002 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0015 0.0006
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0426 0.0287 0.3736
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0062 0.0752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0146 0.1877
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0025 0.0326
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1087 0.0751 0.2128
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0002 0.0004
Onchocerca volvulus 0.0215 0.0139 0.9358
Schistosoma mansoni hypothetical protein 0.0047 0.0021 0.0246
Schistosoma mansoni microtubule-associated protein tau 0.0725 0.0497 0.6482
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0008 0.0082
Echinococcus multilocularis serine protein kinase ATM 0.0617 0.0422 0.0419
Loa Loa (eye worm) phosphatidylinositol kinase 0.0215 0.0139 0.1853
Loa Loa (eye worm) phosphatidylinositol 3 0.0215 0.0139 0.1853
Trypanosoma brucei cytochrome P450, putative 0.0052 0.0025 0.0164
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0234 0.0152 0.1889
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1107 0.0765 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0173
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0603 0.0411 0.0409
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0008 0.0255
Loa Loa (eye worm) glutamate receptor 1 0.0081 0.0045 0.0599
Plasmodium vivax SET domain protein, putative 0.0029 0.0008 0.0474
Brugia malayi Cytochrome P450 family protein 0.0052 0.0025 0.0292
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0008 0.0006
Entamoeba histolytica hypothetical protein 0.0215 0.0139 0.1767
Schistosoma mansoni glutamate receptor NMDA 0.0036 0.0013 0.0148
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.054 0.0368 0.4837
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0215 0.0139 0.7966
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0002 0.0029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0215 0.0139 0.1795
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0266 0.0175 0.0173
Echinococcus multilocularis glutamate receptor 2 0.0076 0.0041 0.0039
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0215 0.0139 0.1799
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0016 0.0183
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0002 0.0004
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0015 0.0193
Schistosoma mansoni alpha glucosidase 0.0038 0.0015 0.0166
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0008 0.003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0603 0.0411 0.536
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0329 0.0219 0.2843
Trypanosoma cruzi cytochrome P450, putative 0.0052 0.0025 0.0035
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0774 0.0532 0.0529
Loa Loa (eye worm) phosphatidylinositol 3 0.0114 0.0068 0.0903
Giardia lamblia GTOR 0.1087 0.0751 1
Leishmania major cytochrome p450-like protein 0.0052 0.0025 0.0033
Echinococcus granulosus glutamate receptor 1 0.0051 0.0024 0.0022
Entamoeba histolytica hypothetical protein 0.0038 0.0015 0.0089
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0012 0.0083
Trichomonas vaginalis set domain proteins, putative 0.0229 0.0149 0.1918
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0002 0.0029
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0008 0.003
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.0108 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.1066 0.0737 0.9808
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.0149 0.0146
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0062 0.0752
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0774 0.0532 0.0529
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0266 0.0175 0.0173
Loa Loa (eye worm) hypothetical protein 0.002 0.0002 0.0029
Brugia malayi Pre-SET motif family protein 0.0029 0.0008 0.0078
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0329 0.0219 0.2865
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0266 0.0175 0.0173
Onchocerca volvulus 0.0099 0.0058 0.3769
Leishmania major hypothetical protein, conserved 0.5195 0.3635 1
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0062 0.0032 0.0029

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 6.4 Modulatory activity at GluA2 receptor LBD ChEMBL. 21190850

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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