Detailed information for compound 1468827

Basic information

Technical information
  • TDR Targets ID: 1468827
  • Name: ZINC06114548
  • MW: 276.4 | Formula: C14H20N4S
  • H donors: 1 H acceptors: 0 LogP: 2.76 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1c(cc(n1CC=C)C)C1=NN=C(SC1)NCC
  • InChi: 1S/C14H20N4S/c1-5-7-18-10(3)8-12(11(18)4)13-9-19-14(15-6-2)17-16-13/h5,8H,1,6-7,9H2,2-4H3,(H,15,17)
  • InChiKey: ABSKDNSHWBYATD-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0053 0.0086 0.008
Giardia lamblia Kinase, PLK 0.4191 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0049 0.0049
Brugia malayi Cytochrome P450 family protein 0.0084 0.016 0.016
Mycobacterium tuberculosis Conserved protein 0.003 0.0029 0.0784
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0305 1
Mycobacterium ulcerans hypothetical protein 0.0057 0.0095 0.5818
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.4191 1 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0056 0.0093 0.5671
Trichomonas vaginalis CAMK family protein kinase 0.4191 1 1
Treponema pallidum NADH oxidase 0.002 0.0006 0.5
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0056 0.0093 0.5671
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0006 0.5
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0056 0.0093 0.2922
Onchocerca volvulus 0.0296 0.0666 0.0658
Echinococcus granulosus GPCR family 2 0.0038 0.0049 0.0044
Leishmania major hypothetical protein, conserved 0.0257 0.0574 0.0568
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0086
Leishmania major cytochrome p450-like protein 0.0084 0.016 0.0154
Brugia malayi intermediate filament protein 0.0033 0.0036 0.0036
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0095 0.0089
Loa Loa (eye worm) hypothetical protein 0.0062 0.0108 0.0108
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.1423 0.3367 0.3364
Echinococcus granulosus twitchin 0.0074 0.0136 0.0131
Onchocerca volvulus 0.0033 0.0036 0.0027
Toxoplasma gondii cytochrome p450 superfamily protein 0.0056 0.0093 0.6364
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0021 0.0008 0.0003
Schistosoma mansoni protein kinase 0.0077 0.0143 0.0138
Trichomonas vaginalis CAMK family protein kinase 0.4191 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0101 0.0101
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0056 0.0093 0.5671
Entamoeba histolytica protein kinase , putative 0.0077 0.0143 0.0135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0055 0.1653
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0049 0.0044
Onchocerca volvulus 0.0058 0.0098 0.0089
Brugia malayi Cytochrome P450 family protein 0.0178 0.0384 0.0384
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0021 0.0008 0.019
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0056 0.0093 0.2922
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0056 0.0093 0.5671
Trichomonas vaginalis CAMK family protein kinase 0.4191 1 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0056 0.0093 0.5671
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0029 0.0023
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.013 0.0271 0.0271
Brugia malayi CHE-14 protein 0.0051 0.008 0.008
Echinococcus granulosus defective proboscis extension response 0.0053 0.0086 0.008
Loa Loa (eye worm) cytochrome P450 family protein 0.0084 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.013 0.0269 0.0269
Echinococcus multilocularis musashi 0.0033 0.0036 0.0031
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0077 0.0143 0.0135
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0365 0.036
Leishmania major trypanothione reductase 0.0057 0.0095 0.0089
Schistosoma mansoni hypothetical protein 0.0082 0.0155 0.015
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0056 0.0093 0.2922
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0095 0.5818
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.008 0.0075
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0642 0.0637
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0057 0.0095 0.5818
Loa Loa (eye worm) AUR protein kinase 0.0077 0.0143 0.0143
Onchocerca volvulus 0.0033 0.0036 0.0027
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0049 0.0044
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0086
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0057 0.0095 0.5818
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0056 0.0093 0.5671
Echinococcus granulosus activin receptor type 0.0021 0.0008 0.0003
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0056 0.0093 0.2922
Schistosoma mansoni hypothetical protein 0.0049 0.0076 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0009 0.0003
Echinococcus multilocularis titin 0.0021 0.0009 0.0003
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0006 0.0006
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0021 0.0009 0.0009
Plasmodium falciparum serine/threonine protein kinase, putative 0.0077 0.0143 1
Trichomonas vaginalis Citrate lyase beta chain, putative 0.003 0.0029 0.0023
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0365 0.036
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0095
Schistosoma mansoni cytochrome P450 0.0056 0.0093 0.0088
Schistosoma mansoni kinase 0.3835 0.9148 0.9148
Leishmania major 4-coumarate:coa ligase-like protein 0.0057 0.0095 0.009
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.013 0.0269 0.0269
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0095 0.5818
Echinococcus multilocularis lamin 0.0033 0.0036 0.0031
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0143 0.0138
Echinococcus granulosus serine:threonine protein kinase PLK1 0.4191 1 1
Leishmania major protein kinase, putative 0.0077 0.0143 0.0138
Mycobacterium ulcerans hypothetical protein 0.003 0.0029 0.1521
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0056 0.0093 0.5671
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0155 0.0155
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0038 0.0049 0.0044
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0028 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0056 0.0093 0.0088
Schistosoma mansoni vesicular amine transporter 0.0053 0.0086 0.008
Loa Loa (eye worm) hypothetical protein 0.0065 0.0113 0.0113
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0077 0.0143 0.0135
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0056 0.0093 0.2922
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0036 0.0036
Mycobacterium tuberculosis Probable reductase 0.013 0.027 0.8837
Brugia malayi glutathione reductase 0.0057 0.0095 0.0095
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0056 0.0093 0.2922
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.0247 0.0247
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0143 0.0138
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0095
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0095 0.2998
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0055 0.1653
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0143 0.0138
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0095 0.0089
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0049 0.0076 0.007
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0029 0.0023
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0095
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0056 0.0093 0.5671
Trichomonas vaginalis CAMK family protein kinase 0.4191 1 1
Echinococcus multilocularis 0.0056 0.0093 0.0088
Schistosoma mansoni protein kinase 0.0021 0.0008 0.0003
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0642 0.0637
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.0038 0.0049 0.0044
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0056 0.0093 0.5671
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0056 0.0093 0.2922
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0061
Echinococcus granulosus titin 0.0021 0.0009 0.0003
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0056 0.0093 0.2922
Schistosoma mansoni serine/threonine protein kinase 0.4191 1 1
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0029 0.0023
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.003 0.0029 0.1521
Plasmodium vivax glutathione reductase, putative 0.0057 0.0095 0.6501
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0056 0.0093 0.2922
Onchocerca volvulus Serine\/threonine kinase homolog 0.4191 1 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0056 0.0093 0.2922
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0056 0.0093 0.5671
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0043 0.0061 0.3571
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0056 0.0093 0.5671
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0055 0.1653
Leishmania major 4-coumarate:coa ligase-like protein 0.0057 0.0095 0.009
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0077 0.0143 0.0138
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0029 0.0023
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0095 0.0089
Toxoplasma gondii thioredoxin reductase 0.0057 0.0095 0.6501
Echinococcus multilocularis protein dispatched 1 0.0058 0.0098 0.0092
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0057 0.0095 0.2998
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0056 0.0093 0.5671
Loa Loa (eye worm) TK/KIN16 protein kinase 0.036 0.0821 0.0821
Entamoeba histolytica acyl-CoA synthetase, putative 0.0057 0.0095 0.0087
Loa Loa (eye worm) AUR protein kinase 0.0077 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0038 0.0049 0.0049
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0021 0.0008 0.0003
Schistosoma mansoni hypothetical protein 0.0049 0.0076 0.007
Schistosoma mansoni survival motor neuron protein 0.0058 0.0098 0.0092
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0057 0.0095 0.5818
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0077 0.0143 0.0138
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0086
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0056 0.0093 0.2922
Echinococcus multilocularis protein patched 0.0051 0.008 0.0075
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0056 0.0093 0.5671
Entamoeba histolytica acyl-coA synthetase, putative 0.0057 0.0095 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0574 0.0568
Loa Loa (eye worm) hypothetical protein 0.0119 0.0243 0.0243
Trypanosoma brucei trypanothione reductase 0.0057 0.0095 0.0089
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0053 0.0086 0.008
Echinococcus multilocularis aurora kinase A 0.0077 0.0143 0.0138
Onchocerca volvulus Tyrosine kinase homolog 0.0305 0.069 0.0682
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0029 0.0023
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0056 0.0093 0.0088
Brugia malayi Cytochrome P450 family protein 0.0084 0.016 0.016
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0056 0.0093 0.2922
Schistosoma mansoni lamin 0.0033 0.0036 0.0031
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.0574 0.0568
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0056 0.0093 0.5671
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.027 0.8837
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0036 0.0036
Trypanosoma brucei aurora B kinase 0.0077 0.0143 0.0138
Loa Loa (eye worm) cytochrome P450 0.0056 0.0093 0.0093
Echinococcus granulosus cytochrome P450 2K1 0.0056 0.0093 0.0088
Echinococcus granulosus lamin 0.0033 0.0036 0.0031
Schistosoma mansoni hypothetical protein 0.0049 0.0076 0.007
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0043 0.0061 0.184
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0056 0.0093 0.5671
Echinococcus granulosus neuroglian 0.0058 0.0098 0.0092
Plasmodium falciparum thioredoxin reductase 0.0057 0.0095 0.6501
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.027 0.8837
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2305 0.23
Schistosoma mansoni hypothetical protein 0.0038 0.0049 0.0044
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0095 0.2985
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0084 0.016 1
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0049 0.0049
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.027 0.8837
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0077 0.0143 0.0135
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0006 0.5
Giardia lamblia Aurora kinase 0.0077 0.0143 0.0138
Trypanosoma cruzi cytochrome P450, putative 0.0084 0.016 0.0154
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0061
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0029 0.1521
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0243 0.0243
Echinococcus granulosus tyrosine protein kinase Lyn 0.0021 0.0008 0.0003
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0086
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0247 0.0242
Loa Loa (eye worm) hypothetical protein 0.0032 0.0035 0.0035
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0056 0.0093 0.5671
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0056 0.0093 0.2922
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.008 0.008
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0049 0.0044
Echinococcus multilocularis roundabout 2 0.0065 0.0113 0.0108
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0095 0.5818
Echinococcus granulosus expressed conserved protein 0.0112 0.0226 0.022
Brugia malayi hypothetical protein 0.0286 0.0642 0.0642
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0086 0.0086
Schistosoma mansoni patched 1 0.0051 0.008 0.0075
Echinococcus multilocularis activin receptor type 0.0021 0.0008 0.0003
Schistosoma mansoni hypothetical protein 0.0038 0.0049 0.0044
Leishmania major cytochrome p450-like protein 0.0056 0.0093 0.0088
Echinococcus multilocularis twitchin 0.0021 0.0009 0.0003
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0243 0.0235
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0053 0.0086 0.008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.0247 0.0247
Brugia malayi serine/threonine protein kinase 6 0.0077 0.0143 0.0143
Echinococcus granulosus transcription factor eb 0.013 0.0271 0.0265
Brugia malayi protein unc-22 0.0021 0.0009 0.0009
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.0247 0.0247
Schistosoma mansoni intermediate filament proteins 0.0033 0.0036 0.0031
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.4191 1 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0056 0.0093 0.0088
Loa Loa (eye worm) hypothetical protein 0.0053 0.0086 0.0086
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0056 0.0093 0.5671
Echinococcus multilocularis neuroglian 0.0058 0.0098 0.0092
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0043 0.0061 1
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0077 0.0143 1
Trypanosoma cruzi cytochrome P450, putative 0.0084 0.016 0.0154
Entamoeba histolytica acyl-CoA synthetase, putative 0.0057 0.0095 0.0087
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0056 0.0093 0.2922
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0143 0.0138
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0056 0.0093 0.2922
Entamoeba histolytica protein kinase, putative 0.0077 0.0143 0.0135
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0095 0.6501
Onchocerca volvulus 0.0057 0.0095 0.0087
Trichomonas vaginalis CAMK family protein kinase 0.4191 1 1
Schistosoma mansoni protein kinase 0.0021 0.0008 0.0003
Brugia malayi Immunoglobulin I-set domain containing protein 0.036 0.0821 0.0821
Brugia malayi cytochrome P450 0.0056 0.0093 0.0093
Echinococcus granulosus Immunoglobulin 0.0053 0.0086 0.008
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0056 0.0093 0.0088
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.006 0.0101 0.0096
Trypanosoma cruzi aurora B kinase, putative 0.0077 0.0143 0.0138
Brugia malayi serine/threonine kinase 12 0.0077 0.0143 0.0143
Brugia malayi AMP-binding enzyme family protein 0.0057 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0033 0.0036 0.0036
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0305 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0243 0.0238
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.027 0.8837
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0061
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0056 0.0093 0.2922
Echinococcus granulosus Protein patched homolog 1 0.0051 0.008 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0009 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0056 0.0093 0.2922
Loa Loa (eye worm) CYP4Cod1 0.0084 0.016 0.016
Entamoeba histolytica protein kinase, putative 0.0077 0.0143 0.0135
Plasmodium vivax acyl-CoA synthetase, putative 0.0043 0.0061 0.4007
Loa Loa (eye worm) hypothetical protein 0.0065 0.0113 0.0113
Trypanosoma cruzi polo-like protein kinase, putative 0.4191 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0021 0.0009 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.1778 0.4219 0.4216
Entamoeba histolytica serine/threonine protein kinase, putative 0.4191 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0574 0.0568
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0021 0.0008 0.0003
Schistosoma mansoni lamin 0.0033 0.0036 0.0031
Loa Loa (eye worm) hypothetical protein 0.0028 0.0025 0.0025
Trypanosoma brucei cytochrome P450, putative 0.0084 0.016 0.0154
Echinococcus granulosus titin 0.0021 0.0009 0.0003
Loa Loa (eye worm) hypothetical protein 0.0051 0.008 0.008
Trichomonas vaginalis CAMK family protein kinase 0.4191 1 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0056 0.0093 0.2922
Trypanosoma brucei polo-like protein kinase 0.4191 1 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0056 0.0093 0.2922
Echinococcus granulosus lamin dm0 0.0033 0.0036 0.0031
Echinococcus granulosus roundabout 2 0.0065 0.0113 0.0108
Echinococcus multilocularis expressed conserved protein 0.0112 0.0226 0.022
Brugia malayi Fibronectin type III domain containing protein 0.0053 0.0086 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.4191 1 1
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.1423 0.3367 0.3364
Plasmodium falciparum glutathione reductase 0.0057 0.0095 0.6501
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0055 0.1653
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0095 0.5818
Echinococcus granulosus intermediate filament protein 0.0033 0.0036 0.0031
Brugia malayi hypothetical protein 0.0053 0.0086 0.0086
Brugia malayi AMP-binding enzyme family protein 0.0057 0.0095 0.0095
Trypanosoma cruzi polo-like protein kinase, putative 0.4191 1 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0056 0.0093 0.5671
Loa Loa (eye worm) CAMK protein kinase 0.0021 0.0009 0.0009
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0056 0.0093 0.5671
Loa Loa (eye worm) glutathione reductase 0.0057 0.0095 0.0095
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0056 0.0093 0.2922
Echinococcus granulosus aurora kinase A 0.0077 0.0143 0.0138
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0243 0.0238
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0057 0.0095 0.0107
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0095 0.0095
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0305 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0247 0.0247
Echinococcus multilocularis Immunoglobulin 0.0053 0.0086 0.008
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.027 0.8357
Toxoplasma gondii aurora kinase 0.0077 0.0143 1
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0143 0.0138
Loa Loa (eye worm) cytochrome P450 family protein 0.0178 0.0384 0.0384
Entamoeba histolytica protein kinase domain containing protein 0.0077 0.0143 0.0135
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0021 0.0008 0.0003
Schistosoma mansoni titin 0.0021 0.0009 0.0003
Echinococcus multilocularis Immunoglobulin 0.0053 0.0086 0.008
Leishmania major cytochrome p450-like protein 0.0056 0.0093 0.0088
Echinococcus multilocularis transcription factor eb 0.013 0.0271 0.0265
Brugia malayi Cytochrome P450 family protein 0.0056 0.0093 0.0093
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0056 0.0093 0.0088
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0029 0.1521
Trypanosoma brucei protein kinase, putative 0.0021 0.0008 0.0003
Echinococcus multilocularis GPCR, family 2 0.0038 0.0049 0.0044
Loa Loa (eye worm) cytochrome P450 family protein 0.0084 0.016 0.016
Plasmodium falciparum acyl-CoA synthetase 0.0043 0.0061 0.4007
Brugia malayi AMP-binding enzyme family protein 0.0057 0.0095 0.0095
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0305 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.4191 1 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0056 0.0093 0.5671
Schistosoma mansoni hypothetical protein 0.0058 0.0098 0.0092
Leishmania major protein kinase, putative 0.0021 0.0008 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.008 0.0075
Brugia malayi serine/threonine-protein kinase 6 0.0077 0.0143 0.0143
Mycobacterium ulcerans hypothetical protein 0.003 0.0029 0.1521
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0036 0.0036
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0057 0.0095 0.0107
Leishmania major 4-coumarate:coa ligase-like protein 0.0057 0.0095 0.009
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0056 0.0093 0.0088
Loa Loa (eye worm) hypothetical protein 0.0286 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0061
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.008 0.0075
Loa Loa (eye worm) AUR protein kinase 0.0077 0.0143 0.0143
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.003 0.0029 0.0784
Brugia malayi Thioredoxin reductase 0.0057 0.0095 0.0095
Echinococcus multilocularis lamin dm0 0.0033 0.0036 0.0031
Plasmodium falciparum protein kinase, putative 0.0021 0.0008 0.019
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0049 0.0044
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.027 0.8837
Schistosoma mansoni protein kinase 0.0021 0.0008 0.0003
Loa Loa (eye worm) hypothetical protein 0.0082 0.0155 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.1778 0.4219 0.4216
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0021 0.0008 0.0003
Schistosoma mansoni cell adhesion molecule 0.006 0.0101 0.0096
Schistosoma mansoni nephrin 0.0058 0.0098 0.0092

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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