Detailed information for compound 1495449

Basic information

Technical information
  • TDR Targets ID: 1495449
  • Name: 4-hydroxy-7-(phenylamino)naphthalene-2-sulfon ic acid
  • MW: 315.344 | Formula: C16H13NO4S
  • H donors: 3 H acceptors: 4 LogP: 3.11 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cc(cc2c1ccc(c2)Nc1ccccc1)S(=O)(=O)O
  • InChi: 1S/C16H13NO4S/c18-16-10-14(22(19,20)21)9-11-8-13(6-7-15(11)16)17-12-4-2-1-3-5-12/h1-10,17-18H,(H,19,20,21)
  • InChiKey: YGNDWDUEMICDLW-UHFFFAOYSA-N  


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Synonyms

  • 4-hydroxy-7-(phenylamino)-2-naphthalenesulfonic acid
  • 121696-48-8
  • 119-40-4
  • 2-Naphthalenesulfonic acid, 4-hydroxy-7-(phenylamino)-
  • 2-Naphthalenesulfonic acid, 7-anilino-4-hydroxy-
  • 7-Anilino-4-hydroxy-2-naphthalenesulfonic acid
  • NSC1745
  • Phenyl I Acid
  • Phenyl J Acid
  • Phenyl J-acid
  • NSC10451
  • NSC37153
  • Phenyl JAcid
  • 2-Naphthalenesulfonic acid, 7-anilino-4-hydroxy- (8CI)
  • 7-Anilino-4-hydroxynaphthalene-2-sulphonic acid
  • EINECS 204-320-3
  • NSC 10451

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Human immunodeficiency virus type 1 Tat protein Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens small ubiquitin-like modifier 1 Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Staphylococcus aureus (strain N315) Probable nicotinate-nucleotide adenylyltransferase Starlite/ChEMBL No references
Homo sapiens phosphatidylinositol-5-phosphate 4-kinase, type II, alpha Starlite/ChEMBL No references
Trypanosoma brucei gambiense phosphoglycerate kinase, putative No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus Small ubiquitin modifier 2 Get druggable targets OG5_127053 All targets in OG5_127053
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii small ubiquitin family modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium vivax small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Giardia lamblia Sentrin Get druggable targets OG5_127053 All targets in OG5_127053
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Theileria parva ubiquitin, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) pip kinase 2 Get druggable targets OG5_131617 All targets in OG5_131617
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC Get druggable targets OG5_131883 All targets in OG5_131883
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania donovani small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium knowlesi nicotinamide/nicotinic acid mononucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Entamoeba histolytica ubiquitin like protein Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium berghei nicotinamide/nicotinic acid mononucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131617 All targets in OG5_131617
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium falciparum small ubiquitin-related modifier Get druggable targets OG5_127053 All targets in OG5_127053
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Theileria parva hypothetical protein, conserved Get druggable targets OG5_131883 All targets in OG5_131883
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Babesia bovis cytidylyltransferase family protein Get druggable targets OG5_131883 All targets in OG5_131883
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) SMO-1 protein Get druggable targets OG5_127053 All targets in OG5_127053
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Treponema pallidum hypothetical protein Get druggable targets OG5_131883 All targets in OG5_131883
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Onchocerca volvulus Get druggable targets OG5_131617 All targets in OG5_131617
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium knowlesi small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Small ubiquitin-related modifier 2 precursor, putative Get druggable targets OG5_127053 All targets in OG5_127053
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic Get druggable targets OG5_131883 All targets in OG5_131883
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Brugia malayi Ubiquitin-like protein SMT3 Get druggable targets OG5_127053 All targets in OG5_127053
Cryptosporidium hominis ubiquitin-like protein Get druggable targets OG5_127053 All targets in OG5_127053
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_127053 All targets in OG5_127053
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein Get druggable targets OG5_131883 All targets in OG5_131883
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans kinetochore protein Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis Small ubiquitin modifier 2 Get druggable targets OG5_127053 All targets in OG5_127053
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase Get druggable targets OG5_131883 All targets in OG5_131883
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Babesia bovis ubiquitin-like protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K00889 1-phosphatidylinositol-4-phosphate 5-kinase [EC2.7.1.68], putative Get druggable targets OG5_131617 All targets in OG5_131617
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Trypanosoma brucei small ubiquitin-related modifier Get druggable targets OG5_127053 All targets in OG5_127053
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans kinetochore protein Get druggable targets OG5_127053 All targets in OG5_127053
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium berghei small ubiquitin-related modifier, putative Get druggable targets OG5_127053 All targets in OG5_127053
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum small ubiquitin protein, putative Get druggable targets OG5_127053 All targets in OG5_127053
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii Predicted nucleotidyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi Pip kinase protein 2 Get druggable targets OG5_131617 All targets in OG5_131617
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum 6-cysteine protein small ubiquitin-like modifier 1 101 aa 92 aa 28.3 %
Trypanosoma cruzi hypothetical protein, conserved Probable nicotinate-nucleotide adenylyltransferase   189 aa 200 aa 20.5 %
Trypanosoma brucei variant surface glycoprotein (VSG, atypical), putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 171 aa 20.5 %
Trichomonas vaginalis nicotinamide mononucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 210 aa 23.8 %
Giardia lamblia Nicotinamide-nucleotide adenylyltransferase Probable nicotinate-nucleotide adenylyltransferase   189 aa 247 aa 20.6 %
Plasmodium knowlesi cytoskeleton associated protein, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 170 aa 23.5 %
Echinococcus multilocularis squamous cell carcinoma antigen Human immunodeficiency virus type 1 Tat protein   86 aa 79 aa 30.4 %
Entamoeba histolytica NMN adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 204 aa 24.5 %
Trichomonas vaginalis nicotinamide mononucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 205 aa 19.0 %
Giardia lamblia Nicotinamide-nucleotide adenylyltransferase Probable nicotinate-nucleotide adenylyltransferase   189 aa 153 aa 24.2 %
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 406 aa 341 aa 32.0 %
Trypanosoma cruzi hypothetical protein, conserved Probable nicotinate-nucleotide adenylyltransferase   189 aa 200 aa 21.0 %
Entamoeba histolytica nicotinamide nucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 204 aa 24.5 %
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1199 0.1064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.0674 0.1729
Brugia malayi jmjC domain containing protein 0.0115 0.1199 0.1633
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0406 0.1739
Loa Loa (eye worm) hypothetical protein 0.0034 0.0176 0.0067
Loa Loa (eye worm) hypothetical protein 0.0034 0.0176 0.0067
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0245 0.105
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0133 0.0325
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0074 0.0674 0.0829
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 0.2333 1
Plasmodium falciparum phd finger protein, putative 0.0035 0.0193 0.0472
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0176 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0176 0.0017
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0366 0.0321
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0496 0.0557
Brugia malayi chromobox protein homolog 3 0.0047 0.0343 0.0322
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0406 0.0258
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0387 0.1657
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0388 0.0585
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0151 0.0029
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0208 0.2366 0.2249
Giardia lamblia Sentrin 0.0037 0.0216 0.0924
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0698 0.2993
Loa Loa (eye worm) hypothetical protein 0.0037 0.0215 0.0126
Schistosoma mansoni hypothetical protein 0.0032 0.0151 0.0388
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0406 0.1739
Echinococcus multilocularis chromobox protein 1 0.0084 0.0807 0.0666
Mycobacterium ulcerans beta-lactamase 0.0034 0.0176 0.0431
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0176 0.0755
Echinococcus granulosus Small ubiquitin modifier 2 0.0037 0.0216 0.0096
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0345 0.4081 1
Schistosoma mansoni rotamase 0.004 0.0257 0.0659
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 0.2333 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0404 0.173
Plasmodium vivax small ubiquitin-related modifier, putative 0.0037 0.0216 0.0528
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0151 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0074 0.0674 0.0783
Brugia malayi Phosphoglycerate kinase 0.0075 0.0698 0.0866
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0245 0.0139
Schistosoma mansoni terminal deoxycytidyl transferase 0.0064 0.0556 0.1425
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1184 0.2719
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0664 0.0813
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0064 0.0556 0.041
Loa Loa (eye worm) MBCTL1 0.0059 0.0496 0.0557
Echinococcus granulosus nischarin 0.0563 0.683 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0034 0.0176 0.0431
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0034 0.0176 0.0067
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.2333 1
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0345 0.4081 1
Brugia malayi mbt repeat family protein 0.0052 0.0406 0.0418
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.0176 0.0755
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0176 0.0452
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.0698 0.2993
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0406 0.1739
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 0.2333 0.5524
Schistosoma mansoni hypothetical protein 0.0032 0.0151 0.0388
Schistosoma mansoni hypothetical protein 0.032 0.3768 0.9665
Echinococcus granulosus dna polymerase eta 0.0095 0.0942 0.1184
Echinococcus granulosus chromobox protein 1 0.0084 0.0807 0.0982
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.2333 1
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0388 0.0585
Trichomonas vaginalis esterase, putative 0.0034 0.0176 0.0017
Treponema pallidum hypothetical protein 0.0345 0.4081 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0064 0.0556 0.0605
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0406 0.0258
Onchocerca volvulus 0.0196 0.2217 0.3146
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0074 0.0674 0.0531
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.2217 0.5686
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0496 0.0517
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0051 0.0387 0.1657
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0072 0.0656 0.281
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0496 0.1273
Echinococcus multilocularis chromobox protein 1 0.0084 0.0807 0.0666
Brugia malayi Heterochromatin protein 1 0.0084 0.0807 0.1033
Leishmania major hypothetical protein, conserved 0.0034 0.0176 0.0755
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Trypanosoma brucei DNA polymerase eta, putative 0.0095 0.0942 0.4038
Brugia malayi hypothetical protein 0.055 0.6666 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Trichomonas vaginalis DNA polymerase eta, putative 0.0096 0.0959 0.2117
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Mycobacterium ulcerans hypothetical protein 0.0034 0.0176 0.0431
Leishmania major DNA polymerase eta, putative 0.0051 0.0387 0.1657
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1184 0.1546
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 0.2333 1
Onchocerca volvulus Nischarin homolog 0.055 0.6664 1
Leishmania major DNA polymerase eta, putative 0.0095 0.0942 0.4038
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1019 0.1356
Schistosoma mansoni hypothetical protein 0.0035 0.0193 0.0494
Loa Loa (eye worm) pip kinase 2 0.0196 0.2217 0.3191
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0193 0.0092
Echinococcus granulosus chromobox protein 1 0.0084 0.0807 0.0982
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0245 0.105
Leishmania major small ubiquitin protein, putative 0.0037 0.0216 0.0924
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.0674 0.1729
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0406 0.104
Loa Loa (eye worm) hypothetical protein 0.0069 0.0617 0.0742
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.0698 0.2993
Brugia malayi polk-prov protein 0.0052 0.0404 0.0415
Loa Loa (eye worm) hypothetical protein 0.0034 0.0176 0.0067
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1184 0.2719
Brugia malayi Phosphoglycerate kinase 0.0206 0.2333 0.3369
Schistosoma mansoni hypothetical protein 0.0069 0.0617 0.1583
Schistosoma mansoni DNA polymerase eta 0.0095 0.0942 0.2416
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0245 0.105
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.2333 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0496 0.035
Trypanosoma brucei unspecified product 0.0088 0.0859 0.3682
Brugia malayi Bromodomain containing protein 0.0035 0.0193 0.0092
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0133 0.0568
Brugia malayi mbt repeat family protein 0.0052 0.0406 0.0418
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.0959 0.235
Loa Loa (eye worm) hypothetical protein 0.0101 0.1019 0.1356
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0176 0.0431
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0807 0.1033
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0064 0.0556 0.1425
Plasmodium falciparum phosphoglycerate kinase 0.0206 0.2333 0.5717
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0807 0.171
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.2333 0.5984
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0286 0.0234
Mycobacterium ulcerans phosphoglycerate kinase 0.0206 0.2333 0.5717
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0133 0.0325
Brugia malayi follicle stimulating hormone receptor 0.0225 0.2578 0.3744
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Brugia malayi jmjC domain containing protein 0.0043 0.0286 0.0234
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1184 0.5073
Schistosoma mansoni glutaminase 0.033 0.3899 1
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 0.2333 1
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0406 0.0381
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0698 0.2993
Echinococcus multilocularis dna polymerase eta 0.0095 0.0942 0.0803
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1184 0.3036
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 0.2333 0.5717
Giardia lamblia PHD finger protein 15 0.0035 0.0193 0.0825
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.2333 0.5984
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0617 0.0742
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0193 0.0825
Leishmania major hypothetical protein, conserved 0.003 0.0133 0.0568
Brugia malayi glutaminase DH11.1 0.033 0.3899 0.5766
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0072 0.0656 0.1228
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1199 0.1569
Brugia malayi beta-lactamase 0.0034 0.0176 0.0067
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1184 0.1609
Echinococcus granulosus expressed protein 0.004 0.0257 0.0158
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1184 0.5073
Schistosoma mansoni kinase 0.0058 0.0479 0.1228
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Echinococcus granulosus beta LACTamase domain containing family member 0.0034 0.0176 0.0037
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0406 0.104
Loa Loa (eye worm) hypothetical protein 0.006 0.0509 0.0576
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0176 0.0452
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0345 0.4081 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0406 0.104
Echinococcus granulosus dna polymerase kappa 0.0096 0.0959 0.1209
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0286 0.0201
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 0.2333 0.5524
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0037 0.0216 0.0553
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.2333 0.5801
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0193 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1184 0.2719
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0406 0.0354
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0257 0.019
Giardia lamblia Kinase, PLK 0.0114 0.1184 0.5073
Leishmania major DNA polymerase kappa, putative 0.0072 0.0656 0.281
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0151 0.0029
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.046 0.0778
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0176 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0404 0.173
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0176 0.0017
Trypanosoma brucei unspecified product 0.0044 0.0306 0.1309
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0959 0.4111
Loa Loa (eye worm) hypothetical protein 0.0206 0.2333 0.3369
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0216 0.0123
Brugia malayi ImpB/MucB/SamB family protein 0.0095 0.0942 0.1239
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0217 0.2472 0.588
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0176 0.0755
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0193 0.0062
Loa Loa (eye worm) hypothetical protein 0.0059 0.0496 0.0557
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Loa Loa (eye worm) hypothetical protein 0.0196 0.2217 0.3191
Entamoeba histolytica deoxycytidyl transferase, putative 0.0064 0.0556 0.1605
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0345 0.4081 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0286 0.0732
Loa Loa (eye worm) glutaminase 2 0.033 0.3899 0.5766
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 0.2333 1
Mycobacterium ulcerans lipase LipD 0.0034 0.0176 0.0431
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Echinococcus multilocularis dna polymerase kappa 0.0096 0.0959 0.082
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0257 0.0234
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1184 0.1048
Loa Loa (eye worm) hypothetical protein 0.0034 0.0176 0.0067
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0133 0.0568
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0208 0.2366 0.3316
Loa Loa (eye worm) hypothetical protein 0.055 0.6666 1
Echinococcus multilocularis peregrin 0.0035 0.0193 0.0042
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0257 0.019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0074 0.0674 0.0531
Onchocerca volvulus 0.0052 0.0406 0.0354
Trypanosoma cruzi small ubiquitin protein, putative 0.0037 0.0216 0.0924
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0807 0.171
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.0698 0.2993
Trypanosoma brucei small ubiquitin-related modifier 0.0037 0.0216 0.0924
Trichomonas vaginalis glutaminase, putative 0.033 0.3899 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1184 0.1609
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1184 0.2719
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1184 0.2719
Echinococcus granulosus peregrin 0.0035 0.0193 0.0062
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0133 0.0325
Onchocerca volvulus Alhambra homolog 0.0035 0.0193 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0133 0.0568
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.2217 0.5686
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0901 0.2312
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1019 0.1356
Schistosoma mansoni hypothetical protein 0.0032 0.0151 0.0388
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.0959 0.4111
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Loa Loa (eye worm) beta-lactamase 0.0034 0.0176 0.0067
Loa Loa (eye worm) hypothetical protein 0.0095 0.0942 0.1239
Loa Loa (eye worm) hypothetical protein 0.0052 0.0404 0.0415
Brugia malayi Ubiquitin-like protein SMT3 0.0037 0.0216 0.0127
Trypanosoma cruzi DNA polymerase eta, putative 0.0095 0.0942 0.4038
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1184 0.2719
Loa Loa (eye worm) SMO-1 protein 0.0037 0.0216 0.0127
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0193 0.0494
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0064 0.0556 0.0647
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0345 0.4081 1
Trypanosoma brucei polo-like protein kinase 0.0114 0.1184 0.5073
Trypanosoma cruzi small ubiquitin protein, putative 0.0037 0.0216 0.0924
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0074 0.0674 0.1729
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0176 0.0017
Mycobacterium ulcerans esterase/lipase LipP 0.0034 0.0176 0.0431
Giardia lamblia Phosphoglycerate kinase 0.0206 0.2333 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0406 0.0418
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0206 0.2333 0.5
Trypanosoma brucei unspecified product 0.0044 0.0306 0.1309
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0133 0.0568
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0406 0.0418
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0193 0.0472
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0074 0.0674 0.0783
Mycobacterium ulcerans glutaminase 0.033 0.3899 0.9554
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0245 0.105
Trichomonas vaginalis rotamase, putative 0.0039 0.0245 0.0202
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0698 0.2993
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1184 0.1553
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0343 0.0464
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0096 0.0959 0.2117
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0496 0.035
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0193 0.0825
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.0959 0.235
Brugia malayi Pip kinase protein 2 0.0196 0.2217 0.3191
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0496 0.0517
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0698 0.2993
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.2333 0.5801
Toxoplasma gondii small ubiquitin family modifier, putative 0.0037 0.0216 0.0924
Schistosoma mansoni chromobox protein 0.0084 0.0807 0.2071
Loa Loa (eye worm) hypothetical protein 0.0047 0.0343 0.0322
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0556 0.0647
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0366 0.0218
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0028 0.01 0.0429
Loa Loa (eye worm) hypothetical protein 0.0032 0.0151 0.0029
Loa Loa (eye worm) hypothetical protein 0.0034 0.0176 0.0067
Loa Loa (eye worm) hypothetical protein 0.0035 0.0193 0.0092
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1019 0.1356
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 0.2333 0.3267
Giardia lamblia DINP protein human, muc B family 0.0072 0.0656 0.281
Plasmodium falciparum small ubiquitin-related modifier 0.0037 0.0216 0.0528
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0074 0.0674 0.0829
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.2217 0.3093
Schistosoma mansoni hypothetical protein 0.0032 0.0151 0.0388
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.0556 0.0972
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.0959 0.4111
Schistosoma mansoni chromobox protein 0.0084 0.0807 0.2071
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0286 0.0136
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.2217 0.2098
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1184 0.2719
Brugia malayi PHD-finger family protein 0.0035 0.0193 0.0092
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0034 0.0176 0.0067
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.2333 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0406 0.0381
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.0656 0.281
Trypanosoma brucei DNA polymerase IV, putative 0.0088 0.0859 0.3682
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1184 0.5073
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1184 0.4572
Trichomonas vaginalis rotamase, putative 0.004 0.0257 0.0234
Onchocerca volvulus 0.0037 0.0215 0.006
Echinococcus multilocularis Small ubiquitin modifier 2 0.0037 0.0216 0.0065
Chlamydia trachomatis phosphoglycerate kinase 0.0206 0.2333 0.5
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0245 0.105
Loa Loa (eye worm) hypothetical protein 0.0034 0.0176 0.0067
Echinococcus multilocularis nischarin 0.0563 0.683 0.6781
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0343 0.0257
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.2578 0.3744
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0286 0.0732
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.046 0.0778
Toxoplasma gondii ABC1 family protein 0.0034 0.0176 0.0755
Brugia malayi beta-lactamase family protein 0.0034 0.0176 0.0067
Echinococcus multilocularis beta LACTamase domain containing family member 0.0034 0.0176 0.0025
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0388 0.0326
Brugia malayi beta-lactamase family protein 0.0034 0.0176 0.0067
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0698 0.2993
Echinococcus multilocularis expressed protein 0.004 0.0257 0.0107
Loa Loa (eye worm) glutaminase 0.033 0.3899 0.5766
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0343 0.0464
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 0.2333 0.2215

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 95.906 uM PUBCHEM_BIOASSAY: C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504431] ChEMBL. No reference
AC50 (functional) = 241.232 uM PUBCHEM_BIOASSAY: 24 hour HeLa Cytotox assay Measured in Cell-Based System Using Plate Reader - 2117-03_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504431] ChEMBL. No reference
IC50 (functional) 2.16 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence resonance energy transfer assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 12.488 uM PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 15.9 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 40.3 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay - Set 2. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 40.9 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 66.6 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Inhibitors of PI5P4K: Confirmation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 2.5902 uM PubChem BioAssay. qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6679 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.4662 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.6213 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.4591 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1: Hit Validation using Tamra Binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.0115 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.3313 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 43.6412 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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