Detailed information for compound 1497848

Basic information

Technical information
  • TDR Targets ID: 1497848
  • Name: N-[4-[2-[(4-chlorophenyl)amino]-2-oxoethyl]-1 ,3-thiazol-2-yl]-N-(3-dimethylaminopropyl)pro panamide hydrochloride
  • MW: 445.406 | Formula: C19H26Cl2N4O2S
  • H donors: 1 H acceptors: 3 LogP: 3.75 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)N(c1scc(n1)CC(=O)Nc1ccc(cc1)Cl)CCCN(C)C.Cl
  • InChi: 1S/C19H25ClN4O2S.ClH/c1-4-18(26)24(11-5-10-23(2)3)19-22-16(13-27-19)12-17(25)21-15-8-6-14(20)7-9-15;/h6-9,13H,4-5,10-12H2,1-3H3,(H,21,25);1H
  • InChiKey: OCFIFRGHCFPRGD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[2-[(4-chlorophenyl)amino]-2-oxo-ethyl]thiazol-2-yl]-N-(3-dimethylaminopropyl)propanamide hydrochloride
  • N-[4-[2-[(4-chlorophenyl)amino]-2-oxoethyl]-2-thiazolyl]-N-(3-dimethylaminopropyl)propanamide hydrochloride
  • N-[4-[2-[(4-chlorophenyl)amino]-2-keto-ethyl]thiazol-2-yl]-N-(3-dimethylaminopropyl)propionamide hydrochloride
  • N-[4-[2-[(4-chlorophenyl)amino]-2-oxo-ethyl]-1,3-thiazol-2-yl]-N-(3-dimethylaminopropyl)propanamide hydrochloride
  • MLS000687579
  • SMR000283329

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus L aminoadipate semialdehyde 0.0163 0.0997 0.11
Echinococcus granulosus nuclear factor of activated T cells 5 0.0071 0.0376 0.0415
Echinococcus granulosus intermediate filament protein 0.0026 0.0069 0.0076
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0134 0.0801 0.08
Toxoplasma gondii ImpB/MucB/SamB family protein 0.009 0.05 0.1589
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.028 0.0865
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0572 0.3775 0.607
Brugia malayi jmjC domain containing protein 0.0187 0.1163 0.2138
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0127 0.036
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0021 0.0021
Trypanosoma cruzi DNA damage repair protein, putative 0.004 0.0161 0.0472
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0198 0.0218
Trypanosoma cruzi trypanothione reductase, putative 0.0466 0.3056 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0127 0.0171
Trypanosoma cruzi DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0023 0.0026
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0851 0.2745
Brugia malayi Bromodomain containing protein 0.0057 0.028 0.0515
Echinococcus multilocularis tumor protein p63 0.0328 0.2118 0.2338
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0127 0.036
Plasmodium vivax ferrodoxin reductase, putative 0.0043 0.0183 0.0546
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0187 0.1163 0.1283
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0043 0.0183 0.0266
Toxoplasma gondii peptidylprolyl isomerase 0.0096 0.054 0.1721
Onchocerca volvulus Alhambra homolog 0.0057 0.028 0.0343
Loa Loa (eye worm) hypothetical protein 0.0065 0.0336 0.0618
Trypanosoma brucei DNA polymerase IV, putative 0.0147 0.089 0.2871
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0017 0.0019
Trypanosoma brucei DNA damage repair protein, putative 0.004 0.0161 0.0472
Schistosoma mansoni sulfide quinone reductase 0.0043 0.0183 0.0183
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0021 0.0023
Leishmania major DNA damage repair protein, putative 0.004 0.0161 0.0472
Trypanosoma cruzi DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0262
Mycobacterium ulcerans hypothetical protein 0.0043 0.0183 0.0137
Mycobacterium tuberculosis Probable dehydrogenase 0.1064 0.711 0.8958
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0017 0.0019
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0019 0.0005
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0528 0.0971
Trichomonas vaginalis glutamate synthase, putative 0.0043 0.0183 0.0262
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0203 0.061
Trypanosoma cruzi NADH dehydrogenase, putative 0.0043 0.0183 0.0546
Trypanosoma cruzi DNA damage repair protein, putative 0.004 0.0161 0.0472
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0021 0.0023
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0019 0.0005
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0127 0.0233
Leishmania major DNA polymerase kappa, putative 0.0134 0.0801 0.2581
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.028 0.0865
Echinococcus granulosus jumonji domain containing protein 0.008 0.0432 0.0477
Brugia malayi Pre-SET motif family protein 0.0818 0.5439 1
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0017 0.0019
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0023 0.0042
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0021 0.0021
Schistosoma mansoni rotamase 0.0098 0.0556 0.0556
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0162 0.0988 0.3196
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0556 0.0865
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0127 0.036
Trypanosoma brucei DNA polymerase IV, putative 0.0154 0.0933 0.3014
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0113 0.0658 0.0727
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0134 0.0801 0.2581
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0262
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0362 0.0362
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0046 0.0203 0.0257
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0043 0.0183 0.0546
Plasmodium vivax glutathione reductase, putative 0.0466 0.3056 1
Loa Loa (eye worm) programmed cell death 8 0.0043 0.0183 0.0336
Brugia malayi hypothetical protein 0.0019 0.0021 0.0039
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0046 0.0203 0.1216
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0043 0.0183 0.0546
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0572 0.3775 0.607
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0103
Entamoeba histolytica deoxycytidyl transferase, putative 0.0128 0.0758 0.1963
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0128 0.0758 0.0837
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0607 0.1115
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0032
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0043 0.0183 0.0137
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0262
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0117 0.0688 0.0688
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0039
Giardia lamblia PHD finger protein 15 0.0057 0.028 0.0528
Schistosoma mansoni disulfide oxidoreductase 0.0043 0.0183 0.0183
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0988 0.3196
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0043 0.0183 0.0262
Trichomonas vaginalis rotamase, putative 0.0098 0.0556 0.0865
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0183 0.0546
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0528 0.1351
Leishmania major phosphopantetheinyl transferase-like protein 0.0046 0.0203 0.061
Brugia malayi jmjC domain containing protein 0.0018 0.0017 0.0032
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0043 0.0183 0.0336
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0043 0.0183 0.0336
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0043 0.0183 0.0546
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0198 0.0364
Giardia lamblia Thioredoxin reductase 0.0043 0.0183 0.0266
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0043 0.0183 0.0202
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0162 0.0988 0.5084
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0607 0.2738
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0162 0.0988 0.3196
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0043 0.0183 0.0202
Mycobacterium ulcerans DNA polymerase IV 0.0154 0.0933 0.4744
Leishmania major NADH dehydrogenase, putative 0.0043 0.0183 0.0546
Onchocerca volvulus 0.0043 0.0183 0.0185
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0017 0.0032
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.0693 0.1274
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0801 0.2581
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0039
Onchocerca volvulus 0.0048 0.0218 0.0242
Schistosoma mansoni DNA polymerase IV / kappa 0.004 0.0161 0.0161
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0572 0.3775 0.607
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0163 0.0997 0.0997
Plasmodium vivax hypothetical protein, conserved 0.0057 0.028 0.0865
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0085 0.017
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.096 0.1004
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0043 0.0183 0.0546
Echinococcus granulosus geminin 0.0332 0.2143 0.2366
Brugia malayi glutathione reductase 0.0466 0.3056 0.5619
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0162 0.0988 1
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0021 0.0039
Leishmania major trypanothione reductase 0.0466 0.3056 1
Trichomonas vaginalis mercuric reductase, putative 0.0162 0.0988 0.1564
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0528 0.1681
Toxoplasma gondii selenide, water dikinase 0.0043 0.0183 0.0546
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0043 0.0183 0.0997
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0046 0.0203 0.061
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0085 0.0223
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0988 0.3196
Toxoplasma gondii hypothetical protein 0.0048 0.0219 0.0664
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0528 0.082
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0046 0.0204 0.0615
Trypanosoma brucei unspecified product 0.0088 0.0489 0.1553
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0021 0.0039
Entamoeba histolytica disulphide oxidoreductase, putative 0.0043 0.0183 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0127 0.0171
Schistosoma mansoni hypothetical protein 0.0332 0.2143 0.2143
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0058 0.0134
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0043 0.0183 0.0431
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0021 0.0039
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0046 0.0203 0.061
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0336 0.1049
Treponema pallidum thioredoxin reductase (trxB) 0.0043 0.0183 0.0266
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0177 0.0526
Brugia malayi 6-phosphofructokinase 0.0105 0.0607 0.1115
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0043 0.0183 0.0202
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0128 0.0758 0.1394
Giardia lamblia Kinase, PLK 0.0094 0.0528 0.1201
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0127 0.0281
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0607 0.0669
Brugia malayi jmjC domain containing protein 0.0018 0.0017 0.0032
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0177 0.0526
Trypanosoma brucei unspecified product 0.0088 0.0489 0.1553
Giardia lamblia DNA damage repair protein 0.004 0.0161 0.0205
Trichomonas vaginalis glutamate synthase, putative 0.0043 0.0183 0.0262
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0043 0.0183 0.0546
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0103
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0021 0.0023
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0021 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0688 0.0688
Brugia malayi jmjC domain containing protein 0.0018 0.0017 0.0032
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0043 0.0183 0.0202
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0094 0.0252
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0085 0.0223
Echinococcus multilocularis lamin 0.0026 0.0069 0.0076
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0528 0.1681
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Echinococcus granulosus dna polymerase eta 0.0178 0.1097 0.1211
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0085 0.0223
Leishmania major DNA polymerase eta, putative 0.009 0.05 0.1589
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0098 0.0556 0.1022
Trypanosoma cruzi DNA polymerase eta, putative 0.009 0.05 0.1589
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0043 0.0183 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.0533 0.1696
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0162 0.0988 0.5084
Brugia malayi Pre-SET motif family protein 0.0117 0.0688 0.1264
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0043 0.0183 0.0137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0572 0.3775 0.607
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0085 0.0103
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0607 0.1115
Trypanosoma brucei DNA damage repair protein, putative 0.004 0.0161 0.0472
Echinococcus granulosus histone lysine methyltransferase setb 0.0117 0.0688 0.0759
Trypanosoma cruzi trypanothione reductase, putative 0.0162 0.0988 0.3196
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0161 0.0472
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0607 0.0947
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0021 0.0023
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0043 0.0183 0.0546
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0043 0.0183 0.0546
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0607 0.1939
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0607 0.156
Brugia malayi jmjC domain containing protein 0.0018 0.0017 0.0032
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0043 0.0183 0.0431
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0127 0.036
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0058 0.0134
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0802 0.5334 0.5888
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0043 0.0183 0.0546
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0183 0.0546
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0043 0.0183 0.0202
Echinococcus multilocularis expressed protein 0.0371 0.2406 0.2655
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0017 0.0017
Schistosoma mansoni terminal deoxycytidyl transferase 0.0128 0.0758 0.0758
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0096 0.054 0.1721
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0021 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Mycobacterium ulcerans hypothetical protein 0.0157 0.096 0.4907
Brugia malayi glutamate synthase 0.0043 0.0183 0.0336
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0607 0.1115
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0183 0.0546
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0096 0.054 0.1383
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0039
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0032
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0162 0.0988 0.3196
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0336 0.1049
Trypanosoma brucei DNA polymerase IV, putative 0.0154 0.0933 0.3014
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0048 0.0088
Trypanosoma brucei polo-like protein kinase 0.0094 0.0528 0.1681
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0362 0.0362
Echinococcus granulosus dna polymerase kappa 0.0154 0.0933 0.103
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0069 0.0127
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0017 0.0019
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0607 0.156
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0017 0.0019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0048 0.0048
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0103
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0262
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0198 0.0218
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0607 0.1939
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0269 0.0111
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0162 0.0988 0.3196
Loa Loa (eye worm) thioredoxin reductase 0.0466 0.3056 0.5619
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0162 0.0988 0.1091
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0021 0.0023
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0043 0.0183 0.0137
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0161 0.0472
Echinococcus multilocularis peregrin 0.0057 0.028 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0046 0.0203 0.0025
Brugia malayi hypothetical protein 0.0024 0.0058 0.0107
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0085 0.0223
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0094 0.0252
Brugia malayi AF-10 protein 0.0019 0.0019 0.0034
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0058 0.0134
Brugia malayi PXA domain containing protein 0.0019 0.0021 0.0039
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0177 0.0526
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0162 0.0988 0.3196
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0021 0.0023
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0043 0.0183 0.0546
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0162 0.0988 1
Trichomonas vaginalis rotamase, putative 0.0096 0.054 0.0839
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0262
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0198 0.0198
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0528 0.082
Mycobacterium leprae conserved hypothetical protein 0.0046 0.0203 0.0025
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.028 0.0309
Brugia malayi Thioredoxin reductase 0.0466 0.3056 0.5619
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0269 0.0666
Echinococcus granulosus expressed protein 0.0371 0.2406 0.2655
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.028 0.1789 0.2077
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.028 0.0515
Echinococcus multilocularis microtubule associated protein 2 0.1352 0.906 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0607 0.1413
Echinococcus granulosus thioredoxin glutathione reductase 0.0469 0.3073 0.3392
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0058 0.0134
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0851 0.2745
Echinococcus granulosus lamin 0.0026 0.0069 0.0076
Mycobacterium tuberculosis Probable reductase 0.1064 0.711 0.8958
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0043 0.0183 0.0202
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0043 0.0183 0.0202
Brugia malayi MH2 domain containing protein 0.0234 0.1478 0.2718
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0162 0.0988 0.3196
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0607 0.0669
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0094 0.0252
Leishmania major hypothetical protein, conserved 0.0043 0.0183 0.0546
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.003 0.0094 0.0252
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0043 0.0183 0.0546
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.003 0.0094 0.0252
Schistosoma mansoni transcription factor btf3 0.0035 0.0127 0.0127
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0043 0.0183 0.0137
Echinococcus multilocularis dna polymerase eta 0.0178 0.1097 0.1211
Leishmania major hypothetical protein, conserved 0.0024 0.0058 0.0134
Loa Loa (eye worm) hypothetical protein 0.0048 0.0218 0.04
Brugia malayi 6-phosphofructokinase 0.0105 0.0607 0.1115
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0607 0.1939
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0528 0.0528
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0023 0.0042
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0162 0.0988 0.3196
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0021 0.0023
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0043 0.0183 0.0546
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1183 0.7915 1
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0043 0.0183 0.0262
Brugia malayi hypothetical protein 0.0019 0.0021 0.0039
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0043 0.0183 0.0262
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0244 0.0448
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0117 0.0688 0.0759
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0021 0.0021
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0043 0.0183 0.0546
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.1919 0.6258
Echinococcus granulosus tumor protein p63 0.0328 0.2118 0.2338
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0607 0.156
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0162 0.0988 0.3196
Treponema pallidum NADH oxidase 0.0162 0.0988 0.2448
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0207 0.03
Loa Loa (eye worm) hypothetical protein 0.0026 0.0069 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0161 0.0472
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0019 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Echinococcus multilocularis lamin dm0 0.0026 0.0069 0.0076
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0019 0.0005
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0128 0.0758 0.0758
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.028 0.1789 1
Echinococcus granulosus expressed protein 0.0098 0.0556 0.0613
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0121
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0021 0.0023
Trichomonas vaginalis set domain proteins, putative 0.0931 0.6205 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0178 0.1097 0.3554
Treponema pallidum fructose-bisphosphate aldolase 0.0572 0.3775 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0269 0.0297
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0269 0.0297
Brugia malayi PHD-finger family protein 0.0019 0.0019 0.0034
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0851 0.2745
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0058 0.0134
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0043 0.0183 0.0997
Brugia malayi polk-prov protein 0.0065 0.0336 0.0618
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0572 0.3775 0.607
Schistosoma mansoni hypothetical protein 0.0332 0.2143 0.2143
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0043 0.0183 0.0546
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0085 0.0223
Leishmania major DNA polymerase kappa, putative 0.004 0.0161 0.0472
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0039
Chlamydia trachomatis thioredoxin reductase 0.0043 0.0183 0.1085
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0607 0.0607
Schistosoma mansoni lamin 0.0026 0.0069 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0528 0.0748
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0043 0.0183 0.0546
Echinococcus granulosus transcription factor btf3 0.0035 0.0127 0.014
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0162 0.0988 0.1091
Trypanosoma cruzi NADH dehydrogenase, putative 0.0043 0.0183 0.0546
Brugia malayi ImpB/MucB/SamB family protein 0.0128 0.0758 0.1394
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0098 0.0556 0.1022
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Mycobacterium tuberculosis Probable oxidoreductase 0.1183 0.7915 1
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0021 0.0021
Leishmania major basic transcription factor 3a, putative 0.0035 0.0127 0.036
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0528 0.082
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1183 0.7915 1
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0085 0.0223
Echinococcus multilocularis thioredoxin glutathione reductase 0.0469 0.3073 0.3392
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0161 0.0472
Brugia malayi intermediate filament protein 0.0026 0.0069 0.0127
Treponema pallidum oxidoreductase 0.0043 0.0183 0.0266
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.1919 0.6258
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0043 0.0183 0.0137
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0162 0.0988 0.3196
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0043 0.0183 0.0137
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0177 0.0526
Leishmania major hypothetical protein, conserved 0.0043 0.0183 0.0546
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0069 0.0127
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.1919 0.6258
Mycobacterium ulcerans glutamate synthase subunit beta 0.0043 0.0183 0.0137
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0162 0.0988 0.0988
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0046 0.0203 0.0257
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0187 0.1163 0.1283
Entamoeba histolytica hypothetical protein 0.0035 0.0127 0.0281
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0162 0.0988 0.5084
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0269 0.0495
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0572 0.3775 0.607
Echinococcus granulosus phd:f box containing protein 0.0018 0.0017 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0572 0.3775 0.607
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0117 0.0688 0.2206
Mycobacterium ulcerans ferredoxin reductase 0.0043 0.0183 0.0137
Trichomonas vaginalis apoptosis inducing factor, putative 0.0043 0.0183 0.0262
Plasmodium falciparum DNA repair protein REV1, putative 0.004 0.0161 0.0472
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0021 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0207 0.03
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0017 0.0019
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0017 0.0017
Schistosoma mansoni glutamate synthase 0.0043 0.0183 0.0183
Trypanosoma brucei chrX additional, unordered contigs 0.004 0.0161 0.0472
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0043 0.0183 0.0997
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0528 0.082
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0023 0.0023
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0085 0.0223
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1183 0.7915 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0163 0.0997 0.1832
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0161 0.0472
Brugia malayi jmjC domain containing protein 0.0069 0.0362 0.0665
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0023 0.0042
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0021 0.0021
Mycobacterium ulcerans DNA polymerase IV 0.0154 0.0933 0.4744
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1064 0.711 0.8958
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0058 0.0134
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0021 0.0023
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0119 0.0697 0.1282
Brugia malayi beta-NAC-like protein 0.0035 0.0127 0.0233
Schistosoma mansoni hypothetical protein 0.0019 0.0019 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.1919 0.6258
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.028 0.1789 0.2077
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0198 0.0218
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0021 0.0023
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0128 0.0758 0.0837
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0021 0.0023
Onchocerca volvulus 0.0117 0.0688 0.1008
Schistosoma mansoni glutamate synthase 0.0043 0.0183 0.0183
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0023 0.0023
Mycobacterium ulcerans dehydrogenase 0.0043 0.0183 0.0137
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0183 0.0546
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0043 0.0183 0.0202
Trypanosoma brucei DNA polymerase eta, putative 0.0178 0.1097 0.3554
Schistosoma mansoni hypothetical protein 0.0057 0.028 0.028
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1064 0.711 0.8958
Entamoeba histolytica thioredoxin reductase, putative 0.0043 0.0183 0.0431
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0572 0.3775 1
Onchocerca volvulus 0.0163 0.0997 0.1511
Brugia malayi ImpB/MucB/SamB family protein 0.0178 0.1097 0.2018
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0203 0.061
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0162 0.0988 1
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0043 0.0183 0.0431
Giardia lamblia Glutamate synthase 0.0043 0.0183 0.0266
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0607 0.0947
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0162 0.0988 0.3196
Toxoplasma gondii thioredoxin reductase 0.0466 0.3056 1
Trypanosoma brucei unspecified product 0.0147 0.089 0.2871
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0988 0.3196
Plasmodium vivax DNA repair protein REV1, putative 0.004 0.0161 0.0472
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0117 0.0688 0.0759
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0362 0.0399
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0988 0.3196
Entamoeba histolytica hypothetical protein 0.0046 0.0203 0.0484
Mycobacterium tuberculosis Conserved hypothetical protein 0.0128 0.0758 0.0744
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0607 0.0947
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0039
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0607 0.0548
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0046 0.0203 0.0319
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0528 0.1681
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0528 0.082
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0162 0.0988 0.1817
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0198 0.0198
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0198 0.0218
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0154 0.0933 0.1475
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0021 0.0023
Plasmodium falciparum phd finger protein, putative 0.0057 0.028 0.0865
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0162 0.0988 0.3196
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0117 0.0688 0.1264
Loa Loa (eye worm) hypothetical protein 0.0163 0.0997 0.1832
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0119 0.0697 0.1282
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.0533 0.1696
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0043 0.0183 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0127 0.0171
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0162 0.0988 0.3196
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0021 0.0023
Plasmodium vivax SET domain protein, putative 0.0117 0.0688 0.2206
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0466 0.3056 0.3716
Loa Loa (eye worm) hypothetical protein 0.0178 0.1097 0.2018
Giardia lamblia DINP protein human, muc B family 0.0134 0.0801 0.1942
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0046 0.0203 0.1302
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.1478 0.2718
Loa Loa (eye worm) hypothetical protein 0.0098 0.0557 0.1024
Echinococcus multilocularis jumonji domain containing protein 0.008 0.0432 0.0477
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0127 0.036
Toxoplasma gondii NADPH-glutathione reductase 0.0162 0.0988 0.3196
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0988 0.3196
Onchocerca volvulus 0.0931 0.6206 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1064 0.711 0.8958
Echinococcus multilocularis L aminoadipate semialdehyde 0.0163 0.0997 0.11
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0017 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0688 0.0688
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0162 0.0988 0.3196
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.0533 0.1696
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0218 0.0218
Plasmodium falciparum thioredoxin reductase 0.0466 0.3056 1
Echinococcus multilocularis expressed protein 0.0098 0.0556 0.0613
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0069 0.0127
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0239 0.0731
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0607 0.0548
Plasmodium vivax thioredoxin reductase, putative 0.0466 0.3056 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0162 0.0988 0.2448
Leishmania major hypothetical protein, conserved 0.0043 0.0183 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0043 0.0183 0.0137
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0043 0.0183 0.0336
Echinococcus granulosus microtubule associated protein 2 0.1352 0.906 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0021 0.0039
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0103
Leishmania major DNA polymerase eta, putative 0.0178 0.1097 0.3554
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0043 0.0183 0.0202
Brugia malayi phosphofructokinase 0.0105 0.0607 0.1115
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0043 0.0183 0.0202
Plasmodium falciparum glutathione reductase 0.0466 0.3056 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0021 0.0039
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0071 0.0376 0.0415
Plasmodium falciparum glutathione reductase 0.0162 0.0988 0.3196
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0269 0.0269
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0017 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0572 0.3775 0.607
Schistosoma mansoni intermediate filament proteins 0.0026 0.0069 0.0069
Schistosoma mansoni jumonji domain containing protein 0.0149 0.0902 0.0902
Schistosoma mansoni sulfide quinone reductase 0.0043 0.0183 0.0183
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0528 0.0971
Schistosoma mansoni glutamate synthase 0.0043 0.0183 0.0183
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0198 0.0198
Echinococcus multilocularis transcription factor btf3 0.0035 0.0127 0.014
Echinococcus multilocularis dna polymerase kappa 0.0154 0.0933 0.103
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0096 0.054 0.1721
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0057 0.028 0.0515
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0528 0.0583
Echinococcus multilocularis musashi 0.0026 0.0069 0.0076
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0607 0.0607
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1064 0.711 0.8958
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0096 0.054 0.1721
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.028 0.0309
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0021 0.0039
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0572 0.3775 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0198 0.0364
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0058 0.0134
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0021 0.0023
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0019 0.0005
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0021 0.0039
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0019 0.0005
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0021 0.0039
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0528 0.0583
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0021 0.0023
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0021 0.0021
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0269 0.0666
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0017 0.0032
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0607 0.0947
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0017 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0183 0.0546
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0183 0.0546
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0269 0.0829
Brugia malayi PHD-finger family protein 0.0057 0.028 0.0515
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0043 0.0183 0.0546
Mycobacterium ulcerans NADH dehydrogenase 0.0043 0.0183 0.0137
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0262
Trichomonas vaginalis DNA polymerase eta, putative 0.0154 0.0933 0.1475
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0988 0.3196
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0162 0.0988 0.3196
Plasmodium falciparum thioredoxin reductase 0.0162 0.0988 0.3196
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0183 0.0546
Giardia lamblia Fructose-bisphosphate aldolase 0.0572 0.3775 1
Brugia malayi PXA domain containing protein 0.0019 0.0021 0.0039
Loa Loa (eye worm) glutathione reductase 0.0466 0.3056 0.5619
Echinococcus multilocularis glutamate synthase 0.0043 0.0183 0.0202
Echinococcus granulosus lamin dm0 0.0026 0.0069 0.0076
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0096 0.054 0.1721
Schistosoma mansoni lamin 0.0026 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0043 0.0183 0.0183
Plasmodium falciparum ferrodoxin reductase-like protein 0.0043 0.0183 0.0546
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.1478 0.2718
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0043 0.0183 0.0546
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0017 0.0032
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0021 0.0021
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0017 0.0019
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.028 0.028
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0362 0.0399
Echinococcus multilocularis geminin 0.0332 0.2143 0.2366
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0043 0.0183 0.0202
Schistosoma mansoni microtubule-associated protein tau 0.1352 0.906 0.906
Schistosoma mansoni DNA polymerase eta 0.0178 0.1097 0.1097
Trypanosoma brucei NADH dehydrogenase 0.0043 0.0183 0.0546
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0103
Echinococcus granulosus glutamate synthase 0.0043 0.0183 0.0202
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0688 0.0688
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0528 0.082
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0043 0.0183 0.0202
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0528 0.082
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1064 0.711 0.8958
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0043 0.0183 0.0431
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0023 0.0026
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0203 0.061
Echinococcus granulosus peregrin 0.0057 0.028 0.0309
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0103
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0818 0.5439 1
Trichomonas vaginalis glutathione reductase, putative 0.0162 0.0988 0.1564
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0362 0.0665
Trypanosoma brucei trypanothione reductase 0.0466 0.3056 1
Echinococcus granulosus Solute carrier family 22 5 0.1003 0.6697 0.7392
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0127 0.036
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0034
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0162 0.0988 0.1042
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0162 0.0988 0.3196
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0043 0.0183 0.0431
Loa Loa (eye worm) hypothetical protein 0.0043 0.0183 0.0336
Schistosoma mansoni kinase 0.0048 0.0215 0.0215
Mycobacterium ulcerans monoxygenase 0.0043 0.0183 0.0137

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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