Detailed information for compound 1504510

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 364.397 | Formula: C18H25F5N2
  • H donors: 2 H acceptors: 0 LogP: 4.43 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)C[C@H]([C@@H]1CC[C@H](CC1)NCCCC(F)(F)F)N)F
  • InChi: 1S/C18H25F5N2/c19-14-4-7-16(20)13(10-14)11-17(24)12-2-5-15(6-3-12)25-9-1-8-18(21,22)23/h4,7,10,12,15,17,25H,1-3,5-6,8-9,11,24H2/t12-,15-,17-/m1/s1
  • InChiKey: KZDLVPSWMDBGSX-SRCQZFHVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 7 Starlite/ChEMBL References
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus Lysosomal Pro X carboxypeptidase Get druggable targets OG5_139351 All targets in OG5_139351
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni family S28 unassigned peptidase (S28 family) Get druggable targets OG5_139351 All targets in OG5_139351
Schistosoma japonicum ko:K01276 dipeptidyl-peptidase II [EC3.4.14.2], putative Get druggable targets OG5_139351 All targets in OG5_139351
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase Get druggable targets OG5_139351 All targets in OG5_139351
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi serine carboxypeptidase S28, putative dipeptidyl-peptidase 7 492 aa 471 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.003 0.018
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.003 0.018
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.003 0.0025
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.003 0.018
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.003 0.003
Echinococcus granulosus solute carrier family 22 0.0016 0.0017 0.0017
Brugia malayi prolyl oligopeptidase family protein 0.007 0.0388 0.2594
Schistosoma mansoni DNA polymerase IV / kappa 0.0017 0.0025 0.0007
Chlamydia trachomatis pyruvate kinase 0.0035 0.0145 0.023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.003 0.018
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0062 0.0333 0.0907
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.003 0.029
Echinococcus granulosus transcription factor btf3 0.0031 0.0121 0.0121
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0102 0.0698
Plasmodium falciparum peptidase, putative 0.0017 0.0021 0.0075
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0127 0.0256
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0127 0.0194
Echinococcus granulosus solute carrier family 22 0.0016 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0104 0.0209
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0186 0.1012
Trypanosoma brucei unspecified product 0.0038 0.0168 0.2143
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0722 1
Mycobacterium ulcerans DNA polymerase IV 0.0083 0.0475 0.0916
Loa Loa (eye worm) phosphofructokinase 0.0119 0.0722 0.492
Loa Loa (eye worm) hypothetical protein 0.0082 0.0467 0.3187
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0049 0.0075
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0378 0.0378
Leishmania major DNA polymerase kappa, putative 0.0017 0.0025 0.0105
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0049 0.0716
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.014 0.0287
Echinococcus granulosus geminin 0.0329 0.2153 0.2153
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.003 0.029
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.048 0.3192 0.9121
Brugia malayi Serine protease Z688.6 precursor 0.0025 0.0075 0.0444
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0017 0.0118
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0102 0.1947
Trypanosoma brucei transcription factor BTF3, putative 0.0031 0.0121 0.1475
Loa Loa (eye worm) prolyl oligopeptidase 0.0017 0.0021 0.014
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.003 0.0025
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0017 0.0021 0.0003
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0102 0.1947
Treponema pallidum hypothetical protein 0.0175 0.11 0.1731
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0041 0.0186 0.1266
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0049 0.0075
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0075 0.013
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.0722 0.1119
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0021 0.0075
Treponema pallidum penicillin-binding protein (pbp-3) 0.0923 0.6214 1
Plasmodium falciparum basic transcription factor 3b, putative 0.0031 0.0121 0.2379
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0017 0.0017
Brugia malayi Pre-SET motif family protein 0.0228 0.1467 1
Loa Loa (eye worm) sugar transporter 0.0016 0.0017 0.0118
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0017 0.0017
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0075 0.0138
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0145 0.0992
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.003 0.0036
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0075 0.013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0625 0.4182 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0316 0.2102
Mycobacterium tuberculosis Conserved protein 0.0079 0.0447 0.1234
Giardia lamblia DINP protein human, muc B family 0.0062 0.0333 0.0758
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0264
Trichomonas vaginalis DNA polymerase eta, putative 0.0083 0.0475 0.11
Treponema pallidum fructose-bisphosphate aldolase 0.0625 0.4182 0.6714
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0049 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0214 0.2798
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0073 0.0126
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0625 0.4182 1
Echinococcus multilocularis pyruvate kinase 0.0018 0.0029 0.0029
Trypanosoma brucei trypanothione reductase 0.0052 0.0261 0.3467
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0305 0.1995 0.3954
Brugia malayi ImpB/MucB/SamB family protein 0.0082 0.0467 0.3139
Echinococcus multilocularis dna polymerase kappa 0.0083 0.0475 0.0475
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.003 0.018
Trichomonas vaginalis rotamase, putative 0.0034 0.014 0.0294
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0145 0.0989
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0025 0.0105
Echinococcus multilocularis transcription factor btf3 0.0031 0.0121 0.0121
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0127 0.2518
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0049 0.0444
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0127 0.2518
Schistosoma mansoni terminal deoxycytidyl transferase 0.0055 0.0286 0.0269
Loa Loa (eye worm) hypothetical protein 0.0079 0.0447 0.3046
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.003 0.018
Brugia malayi beta-lactamase family protein 0.0079 0.0447 0.2997
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Brugia malayi phosphofructokinase 0.0119 0.0722 0.4885
Schistosoma mansoni hypothetical protein 0.0329 0.2153 0.2139
Brugia malayi Thioredoxin reductase 0.0052 0.0261 0.1725
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0378 0.5122
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0175 0.11 0.3112
Schistosoma mansoni pyruvate kinase 0.0035 0.0145 0.0128
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0447 0.1234
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0625 0.4182 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0625 0.4182 1
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0722 0.1685
Brugia malayi Sugar transporter family protein 0.0016 0.0017 0.0048
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.0715 0.2006
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.0072 0.1247
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0447 0.3046
Giardia lamblia DNA damage repair protein 0.0017 0.0025 0.0018
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0722 1
Leishmania major pyruvate kinase 0.0035 0.0145 0.1815
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0041 0.0048
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0447 0.1234
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0055 0.0286 0.0269
Leishmania major pyruvate kinase 0.0035 0.0145 0.1815
Chlamydia trachomatis transglycolase/transpeptidase 0.037 0.2435 0.4807
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0378 0.2525
Plasmodium vivax DNA repair protein REV1, putative 0.0017 0.0025 0.0169
Trypanosoma brucei DNA polymerase eta, putative 0.0082 0.0467 0.6391
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0131 0.0131
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.008 0.0454 0.3046
Brugia malayi Flap endonuclease-1 0.0029 0.0102 0.0632
Trypanosoma brucei DNA polymerase IV, putative 0.0083 0.0475 0.6504
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0372 0.2448 0.4858
Trichomonas vaginalis esterase, putative 0.0079 0.0447 0.1031
Brugia malayi hypothetical protein 0.0016 0.0017 0.0048
Schistosoma mansoni lamin 0.0028 0.01 0.0082
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0722 0.0706
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0049 0.0075
Toxoplasma gondii hypothetical protein 0.0017 0.0021 0.0075
Echinococcus granulosus Solute carrier family 22 5 0.1135 0.7663 0.7663
Echinococcus multilocularis musashi 0.0028 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.014
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.003 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0121 0.0249
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0305 0.1995 0.5684
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0049 0.0263
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0525 0.3498 1
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0017 0.0021 0.0008
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0083 0.0475 0.11
Echinococcus granulosus transcription factor Dp 1 0.004 0.018 0.018
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0261 0.1783
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0145 0.1815
Leishmania major basic transcription factor 3a, putative 0.0031 0.0121 0.1475
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0316 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0104 0.0209
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0447 0.1031
Trypanosoma brucei prolyl endopeptidase 0.0017 0.0021 0.0046
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0378 0.2578
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0454 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0049 0.0049
Schistosoma mansoni chromobox protein 0.0073 0.0404 0.0388
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0041 0.0058
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0055 0.0286 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0186 0.0405
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0045 0.0214 0.1461
Leishmania major DNA polymerase kappa, putative 0.0062 0.0333 0.4479
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0625 0.4182 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0041 0.0018
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0145 0.0356
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Echinococcus granulosus neuropeptide receptor A26 0.049 0.3255 0.3255
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0017 0.0048
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0017 0.0118
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0316 0.0859
Echinococcus multilocularis lamin 0.0028 0.01 0.01
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0025 0.0075 0.0138
Plasmodium vivax basic transcription factor 3b, putative 0.0031 0.0121 0.2379
Trypanosoma brucei prolyl oligopeptidase, putative 0.0017 0.0021 0.0046
Leishmania major trypanothione reductase 0.0052 0.0261 0.3467
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0025 0.0075 0.0817
Brugia malayi 6-phosphofructokinase 0.0119 0.0722 0.4885
Chlamydia trachomatis transglycolase/transpeptidase 0.075 0.5033 1
Mycobacterium ulcerans hypothetical protein 0.0021 0.0051 0.0067
Echinococcus multilocularis pyruvate kinase 0.0018 0.0029 0.0029
Echinococcus granulosus pyruvate kinase 0.0018 0.0029 0.0029
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.003 0.0025
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0041 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0625 0.4182 1
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0017 0.0048
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0447 0.9836
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0021 0.0071
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0075 0.0138
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0447 0.6097
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0029 0.0275
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0175 0.11 0.2165
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0209 0.1337 0.1337
Onchocerca volvulus 0.0079 0.0447 0.258
Mycobacterium leprae Probable lipase LipE 0.0079 0.0447 0.1218
Echinococcus granulosus pyruvate kinase 0.0018 0.0029 0.0029
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0145 0.0367
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.01 0.0613
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0121 0.0249
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0102 0.0204
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.003 0.018
Leishmania major hypothetical protein, conserved 0.0079 0.0447 0.6097
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.003 0.018
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0625 0.4182 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0127 0.0157
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0206 0.2685
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.0722 0.0722
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0127 0.0264
Giardia lamblia Pyruvate kinase 0.0035 0.0145 0.0307
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.0722 0.1408
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0722 0.1691
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0525 0.3498 0.9933
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0722 0.1691
Schistosoma mansoni hypothetical protein 0.0329 0.2153 0.2139
Entamoeba histolytica hypothetical protein 0.0031 0.0121 0.0242
Echinococcus granulosus chromobox protein 1 0.0073 0.0404 0.0404
Echinococcus granulosus expressed protein 0.0035 0.0145 0.0145
Trypanosoma cruzi DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0145 0.0307
Trypanosoma cruzi DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Plasmodium falciparum thioredoxin reductase 0.0052 0.0261 0.5593
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0075 0.0138
Loa Loa (eye worm) hypothetical protein 0.0079 0.0447 0.3046
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.001 0.007
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0447 0.1031
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0722 0.1691
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0145 0.1815
Brugia malayi beta-lactamase 0.0079 0.0447 0.2997
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0079 0.0447 0.3046
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0447 0.1218
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0055 0.0286 0.1948
Brugia malayi hypothetical protein 0.0016 0.0017 0.0048
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0289 0.1969
Schistosoma mansoni pyruvate kinase 0.0018 0.0029 0.0012
Echinococcus multilocularis dna polymerase eta 0.0082 0.0467 0.0467
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0145 0.0768
Echinococcus granulosus solute carrier family 22 0.0016 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0145 0.0768
Mycobacterium ulcerans lipase LipD 0.0079 0.0447 0.0858
Brugia malayi 6-phosphofructokinase 0.0119 0.0722 0.4885
Trypanosoma cruzi DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0021 0.0008
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0215 0.2811
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0017 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0625 0.4182 1
Echinococcus multilocularis pyruvate kinase 0.0018 0.0029 0.0029
Schistosoma mansoni ap endonuclease 0.002 0.0041 0.0024
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0378 0.0361
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.003 0.018
Trypanosoma brucei unspecified product 0.0038 0.0168 0.2143
Echinococcus granulosus solute carrier family 22 0.0016 0.0017 0.0017
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0145 0.2928
Echinococcus multilocularis neuropeptide s receptor 0.049 0.3255 0.3255
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0722 0.1685
Loa Loa (eye worm) hypothetical protein 0.0028 0.01 0.0679
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0041 0.0041
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0017 0.0017
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0447 0.1234
Leishmania major DNA damage repair protein, putative 0.0017 0.0025 0.0105
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.003 0.029
Trypanosoma cruzi transcription factor btf3, putative 0.0031 0.0121 0.1475
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.1467 1
Echinococcus multilocularis neuropeptide receptor A26 0.049 0.3255 0.3255
Echinococcus multilocularis prolyl endopeptidase 0.0017 0.0021 0.0021
Brugia malayi polk-prov protein 0.0045 0.0214 0.1402
Trypanosoma brucei chrX additional, unordered contigs 0.0017 0.0025 0.0105
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0075 0.0138
Mycobacterium ulcerans epimerase 0.0021 0.0051 0.0067
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0447 0.043
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0017 0.0025 0.0169
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0316 0.4246
Echinococcus multilocularis chromobox protein 1 0.0073 0.0404 0.0404
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0049 0.0263
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0131 0.0131
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0378 0.0378
Toxoplasma gondii NAC domain-containing protein 0.0031 0.0121 0.2379
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0447 0.2997
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0722 0.492
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0049 0.0716
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0025 0.0075 0.0075
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.008 0.0454 0.1238
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0049 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0333 0.4479
Treponema pallidum penicillin-binding protein (pbp-1) 0.075 0.5033 0.8091
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0075 0.0138
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.0748 0.502 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0025 0.0105
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0017 0.0017
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0025 0.0075 0.013
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0041 0.0058
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.051
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0456 0.3027 0.3027
Echinococcus multilocularis solute carrier family 22 0.0016 0.0017 0.0017
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0017 0.0021 0.0007
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0025 0.0075 0.1318
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0131 0.2601
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0127 0.2518
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0187 0.1187 0.3361
Echinococcus granulosus pyruvate kinase 0.0035 0.0145 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0187 0.1187 0.3332
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0127 0.2518
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0041 0.0551
Echinococcus granulosus flap endonuclease 1 0.0029 0.0102 0.0102
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0447 0.0858
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0525 0.3498 0.6956
Brugia malayi major facilitator superfamily protein 0.0016 0.0017 0.0048
Onchocerca volvulus Prolyl endopeptidase homolog 0.0017 0.0021 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0529 0.3521 0.8413
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0145 0.1815
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.051
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.0806 0.2265
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0264
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0025 0.0105
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0127 0.0194
Giardia lamblia Alanyl dipeptidyl peptidase 0.0017 0.0021 0.0008
Trichomonas vaginalis rotamase, putative 0.0035 0.0145 0.0308
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.003 0.0025
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0025 0.0075 0.0817
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.003 0.018
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.0715 0.2006
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0075 0.0138
Plasmodium falciparum glutathione reductase 0.0018 0.003 0.029
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0041 0.0058
Echinococcus granulosus bloom syndrome protein 0.0021 0.0049 0.0049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.003 0.018
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0049 0.0716
Plasmodium falciparum pyruvate kinase 0.0035 0.0145 0.2928
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0127 0.2518
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0062 0.0333 0.4479
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.0722 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.01 0.0082
Mycobacterium ulcerans hypothetical protein 0.0017 0.0025 0.0015
Onchocerca volvulus 0.026 0.1682 1
Echinococcus multilocularis transcription factor Dp 1 0.004 0.018 0.018
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0456 0.3027 0.3027
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0207 0.0455
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0145 0.0926
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0316 0.0598
Mycobacterium ulcerans penicillin-binding lipoprotein 0.048 0.3192 0.6345
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.075 0.5033 1
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.0388 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0186 0.0405
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0017 0.0021 0.0046
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0178 0.1124 0.3179
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0447 0.1031
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0041 0.0282
Echinococcus granulosus acylamino acid releasing enzyme 0.0017 0.0021 0.0021
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0041 0.0341
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.0806 0.2243
Plasmodium vivax SET domain protein, putative 0.0033 0.0131 0.2601
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0025 0.0075 0.0075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0625 0.4182 1
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0102 0.0204
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0049 0.0049
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.0388 0.5264
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.0715 0.2006
Loa Loa (eye worm) hypothetical protein 0.0033 0.0131 0.0892
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0049 0.0716
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0049 0.0049
Echinococcus granulosus lamin dm0 0.0028 0.01 0.01
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0049 0.0049
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0145 0.1815
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0041 0.0214
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.0722 0.2003
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.0388 0.8492
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0404 0.0929
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0017 0.0021 0.0046
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.014 0.2806
Giardia lamblia Pyruvate kinase 0.0018 0.0029 0.0029
Giardia lamblia Fructose-bisphosphate aldolase 0.0625 0.4182 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0127 0.2518
Echinococcus multilocularis solute carrier family 22 0.0016 0.0017 0.0017
Giardia lamblia Serine peptidase, putative 0.0025 0.0075 0.0138
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.003 0.018
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0316 0.0316
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.0722 0.2024
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.003 0.029
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0029 0.0275
Trypanosoma cruzi oligopeptidase b 0.0017 0.0021 0.0046
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0025 0.0105
Echinococcus multilocularis expressed protein 0.0035 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0079 0.0447 0.3046
Trypanosoma cruzi oligopeptidase b 0.0017 0.0021 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Brugia malayi Heterochromatin protein 1 0.0073 0.0404 0.2705
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0209 0.1337 0.1337
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0209 0.1337 0.1322
Loa Loa (eye worm) ICD-1 protein 0.0031 0.0121 0.0826
Onchocerca volvulus 0.0079 0.0447 0.258
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0017 0.0021 0.0075
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0041 0.0069
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0145 0.0926
Trypanosoma brucei DNA polymerase IV, putative 0.0083 0.0475 0.6504
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.008 0.0454 0.1255
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.003 0.018
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0075 0.0138
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0175 0.11 0.3085
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0447 0.1234
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0041 0.0551
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0025 0.0105
Loa Loa (eye worm) beta-lactamase 0.0079 0.0447 0.3046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.003 0.018
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.003 0.018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0055 0.0286 0.0771
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0051 0.028
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0051 0.0202
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0347
Echinococcus granulosus intermediate filament protein 0.0028 0.01 0.01
Plasmodium falciparum DNA repair protein REV1, putative 0.0017 0.0025 0.0169
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0261 0.0261
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0447 0.1234
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0049 0.0444
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0722 0.492
Trypanosoma brucei unspecified product 0.0076 0.0428 0.5836
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0075 0.0138
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0051 0.0087
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0529 0.3521 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0447 0.3046
Entamoeba histolytica transcription factor BTF3, putative 0.0031 0.0121 0.0242
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.0715 0.1985
Brugia malayi Pre-SET motif family protein 0.0033 0.0131 0.0828
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0378 0.5122
Brugia malayi ImpB/MucB/SamB family protein 0.0055 0.0286 0.1892
Trypanosoma cruzi prolyl endopeptidase 0.0017 0.0021 0.0046
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0261 0.5593
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0017 0.0017
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.003 0.003
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.0388 0.0388
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0041 0.0341
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0075 0.0138
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.0715 0.2006
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0447 0.0858
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Echinococcus multilocularis lamin dm0 0.0028 0.01 0.01
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0102 0.0102
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.014 0.174
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0025 0.0105
Trypanosoma brucei DNA polymerase IV, putative 0.0076 0.0428 0.5836
Mycobacterium ulcerans hypothetical protein 0.0079 0.0447 0.0858
Schistosoma mansoni flap endonuclease-1 0.0026 0.0084 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0121 0.0249
Schistosoma mansoni transcription factor btf3 0.0031 0.0121 0.0104
Toxoplasma gondii exonuclease III APE 0.002 0.0041 0.0551
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0529 0.3521 0.7003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0331
Brugia malayi intermediate filament protein 0.0028 0.01 0.0613
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0404 0.2756
Trypanosoma cruzi DNA polymerase eta, putative 0.0082 0.0467 0.6391
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.003 0.0025
Chlamydia trachomatis endonuclease IV 0.008 0.0454 0.0847
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0378 0.5122
Brugia malayi beta-lactamase family protein 0.0079 0.0447 0.2997
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0017 0.0021 0.0046
Trichomonas vaginalis set domain proteins, putative 0.026 0.1682 0.3997
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0017 0.0021 0.0009
Plasmodium falciparum thioredoxin reductase 0.0018 0.003 0.029
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0378 0.5122
Onchocerca volvulus 0.0028 0.01 0.0494
Brugia malayi Sugar transporter family protein 0.0016 0.0017 0.0048
Schistosoma mansoni ap endonuclease 0.002 0.0041 0.0024
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0454 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0214 0.2798
Trypanosoma cruzi DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.0388 0.5264
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0021 0.0046
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0041 0.0341
Brugia malayi major facilitator superfamily protein 0.0016 0.0017 0.0048
Toxoplasma gondii endonuclease IV APN 0.008 0.0454 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0261 0.0702
Entamoeba histolytica deoxycytidyl transferase, putative 0.0055 0.0286 0.0637
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0264
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0049 0.0263
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.003 0.029
Leishmania major oligopeptidase b 0.0017 0.0021 0.0046
Mycobacterium ulcerans DNA polymerase IV 0.0083 0.0475 0.0916
Echinococcus multilocularis pyruvate kinase 0.0035 0.0145 0.0145
Echinococcus multilocularis chromobox protein 1 0.0073 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0145 0.0928
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0017 0.0048
Brugia malayi hypothetical protein 0.0016 0.0017 0.0048
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0207 0.1139
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0025 0.0075 0.0138
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0131 0.0131
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.003 0.0135
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.0722 0.0722
Echinococcus multilocularis solute carrier family 22 0.0016 0.0017 0.0017
Echinococcus multilocularis geminin 0.0329 0.2153 0.2153
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0041 0.0041
Mycobacterium ulcerans endonuclease IV 0.008 0.0454 0.0873
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0145 0.0989
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0447 0.1234
Onchocerca volvulus 0.0079 0.0447 0.258
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0049 0.0067
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.048 0.3192 0.9059
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0025 0.0075 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0215 0.2811
Echinococcus granulosus dna polymerase kappa 0.0083 0.0475 0.0475
Schistosoma mansoni lamin 0.0028 0.01 0.0082
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0127 0.2518
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0025 0.0105
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0447 0.6097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0131 0.0114
Giardia lamblia Alanyl dipeptidyl peptidase 0.0017 0.0021 0.0008
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0021 0.0003
Echinococcus granulosus chromobox protein 1 0.0073 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0054 0.0275 0.1873
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.051
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.0388 0.5264
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.014 0.174
Brugia malayi Sugar transporter family protein 0.0016 0.0017 0.0048
Schistosoma mansoni pyruvate kinase 0.0035 0.0145 0.0128
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0021 0.0003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0123 0.0123
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0017 0.0017
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0017 0.0017
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0102 0.0196
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0145 0.0307
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0102 0.1207
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0102 0.1207
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.0715 0.2006
Brugia malayi Serine protease Z688.6 precursor 0.0025 0.0075 0.0444
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0131 0.0114
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0075 0.0138
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0016 0.0017 0.0017
Schistosoma mansoni DNA polymerase eta 0.0082 0.0467 0.0451
Echinococcus multilocularis pyruvate kinase 0.0027 0.0095 0.0095
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0404 0.0929
Mycobacterium tuberculosis Probable reductase 0.0118 0.0715 0.2006
Echinococcus granulosus neuropeptide s receptor 0.049 0.3255 0.3255
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.003 0.018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0145 0.0989
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0075 0.0138
Mycobacterium tuberculosis Conserved protein 0.0079 0.0447 0.1234
Loa Loa (eye worm) hypothetical protein 0.0079 0.0447 0.3046
Mycobacterium tuberculosis Probable peptidase 0.0017 0.0021 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.014
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0456 0.3027 0.3015
Loa Loa (eye worm) prolyl oligopeptidase 0.0209 0.1337 0.9119
Echinococcus granulosus dna polymerase eta 0.0082 0.0467 0.0467
Loa Loa (eye worm) hypothetical protein 0.0028 0.0096 0.0655
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0206 0.4331
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0049 0.0444
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0722 0.0706
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0316 0.0598
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0372 0.2448 0.6935
Trypanosoma brucei oligopeptidase b 0.0017 0.0021 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Leishmania major DNA polymerase eta, putative 0.0082 0.0467 0.6391
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0145 0.0989
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0145 0.0256
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0055 0.0286 0.0286
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0145 0.2928
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0722 0.1691
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0051 0.0097
Loa Loa (eye worm) intermediate filament protein 0.0028 0.01 0.0679
Plasmodium falciparum flap endonuclease 1 0.0029 0.0102 0.1947
Brugia malayi prolyl oligopeptidase family protein 0.0209 0.1337 0.9113
Loa Loa (eye worm) RecQ helicase 0.0021 0.0049 0.0331
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.014 0.174
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0021 0.0071
Brugia malayi glutathione reductase 0.0052 0.0261 0.1725
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0041 0.0048
Echinococcus granulosus pyruvate kinase 0.0035 0.0145 0.0145
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0021 0.0071
Brugia malayi beta-NAC-like protein 0.0031 0.0121 0.0762
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0025 0.0075 0.0817
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0212 0.0195
Schistosoma mansoni DNA helicase recq1 0.0021 0.0049 0.0031
Onchocerca volvulus 0.0028 0.01 0.0494
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0264
Plasmodium falciparum glutathione reductase 0.0052 0.0261 0.5593
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0075 0.0138
Echinococcus granulosus prolyl endopeptidase 0.0017 0.0021 0.0021
Brugia malayi Serine carboxypeptidase S28 family protein 0.0025 0.0075 0.0444
Schistosoma mansoni chromobox protein 0.0073 0.0404 0.0388
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0051 0.0067
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.014 0.174
Brugia malayi hypothetical protein 0.0054 0.0275 0.1816
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.051
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0447 0.0447
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.0388 0.5264
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0722 0.1685
Echinococcus multilocularis solute carrier family 22 0.0016 0.0017 0.0017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0041 0.0341
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0447 0.6097
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0261 0.3467
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0504 0.3354 0.9588
Toxoplasma gondii thioredoxin reductase 0.0052 0.0261 0.5593
Leishmania major DNA polymerase eta, putative 0.0044 0.0206 0.2685
Onchocerca volvulus 0.0025 0.0075 0.0346
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.014
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0447 0.1031
Giardia lamblia Thymus-specific serine protease precursor 0.0025 0.0075 0.0138
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.0806 0.2265
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0209 0.1337 0.793
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0447 0.1234
Onchocerca volvulus 0.0045 0.0212 0.1171
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0447 0.043
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.003 0.029
Schistosoma mansoni rotamase 0.0035 0.0145 0.0128
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0305 0.1995 0.5642
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0499
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.01 0.0679
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0049 0.0331
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0215 0.2811
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0207 0.0455
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0378 0.0859
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0856
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0017 0.0017
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.0806 0.2265
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0025 0.0075 0.0138
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0447 0.1031
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0021 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0625 0.4182 1
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0017 0.0021 0.0046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0131 0.0114
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0264
Loa Loa (eye worm) hypothetical protein 0.008 0.0454 0.3095
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0075 0.0138
Echinococcus granulosus lamin 0.0028 0.01 0.01
Echinococcus granulosus pyruvate kinase 0.0018 0.0029 0.0029
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.003 0.0013
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0025 0.0075 0.0138
Trypanosoma cruzi transcription factor btf3, putative 0.0031 0.0121 0.1475
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0316 0.0316
Onchocerca volvulus 0.0032 0.0126 0.065
Echinococcus multilocularis pyruvate kinase 0.0035 0.0145 0.0145
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0017 0.0021 0.0008
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0017 0.0021 0.0046
Loa Loa (eye worm) sugar transporter 0.0016 0.0017 0.0118
Mycobacterium tuberculosis Conserved protein 0.0079 0.0447 0.1234
Brugia malayi chromobox protein homolog 3 0.0041 0.0186 0.1205
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0073 0.0499
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0025 0.0105
Treponema pallidum penicillin-binding protein (pbp-2) 0.0529 0.3521 0.5646
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0017 0.0017
Plasmodium vivax glutathione reductase, putative 0.0052 0.0261 0.5593
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0447 0.0447
Toxoplasma gondii prolyl endopeptidase 0.0017 0.0021 0.0075
Schistosoma mansoni DNA helicase recq5 0.0021 0.0049 0.0031
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.0388 0.0371
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0021 0.0046
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.0388 0.5264
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0029 0.0275
Echinococcus multilocularis acylamino acid releasing enzyme 0.0017 0.0021 0.0021
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0102 0.1207
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0145 0.0308
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Loa Loa (eye worm) glutathione reductase 0.0052 0.0261 0.1783
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0264
Toxoplasma gondii ABC1 family protein 0.0079 0.0447 0.9836
Mycobacterium ulcerans beta-lactamase 0.0079 0.0447 0.0858
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0017 0.0021 0.0046
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0145 0.0768
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.003 0.003
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0127 0.0264
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0372 0.2448 0.6984

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.91 uM Inhibition of DPP4 ChEMBL. 21320777
IC50 (binding) = 4.8 uM Inhibition of QPP ChEMBL. 21320777
IC50 (binding) > 35 uM Inhibition of FAP ChEMBL. 21320777
IC50 (binding) = 45 uM Inhibition of DPP9 ChEMBL. 21320777
IC50 (binding) = 75 uM Inhibition of DPP8 ChEMBL. 21320777

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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