Detailed information for compound 1504983

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 457.875 | Formula: C24H19ClF3N3O
  • H donors: 0 H acceptors: 2 LogP: 6.7 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)n1nc2c(c1OCc1ccccc1C(F)(F)F)cnc1c2CCCC1
  • InChi: 1S/C24H19ClF3N3O/c25-16-9-11-17(12-10-16)31-23(32-14-15-5-1-3-7-20(15)24(26,27)28)19-13-29-21-8-4-2-6-18(21)22(19)30-31/h1,3,5,7,9-13H,2,4,6,8,14H2
  • InChiKey: ZTZRTWZVMCXZQV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0031 0.0156
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0668 0.3375 1
Echinococcus multilocularis serotonin receptor 0.0022 0.003 0.0024
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0016 0.0063
Onchocerca volvulus 0.0084 0.0353 0.0348
Echinococcus multilocularis g protein coupled receptor 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0025 0.0341
Plasmodium falciparum thioredoxin reductase 0.0019 0.0016 0.0063
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0031 0.0025
Brugia malayi Dopamine receptor 0.0022 0.003 0.003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0089 0.0376 0.6504
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0074 0.0074
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.003 0.0024
Brugia malayi hypothetical protein 0.0022 0.003 0.003
Leishmania major trypanothione reductase 0.0055 0.0203 0.3467
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0203 0.0198
Plasmodium falciparum transporter, putative 0.0331 0.1628 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus granulosus serotonin receptor 0.0022 0.003 0.0024
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0561 0.2821 0.9933
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.003 0.0024
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.003 0.003
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.003 0.0024
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0022 0.003 0.0024
Schistosoma mansoni amine GPCR 0.0022 0.003 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0016 0.018
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0016 0.0016
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0016 0.0063
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0016 0.001
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0331 0.1628 0.1628
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0098 0.0092
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0248 0.0598
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.003 0.0024
Echinococcus granulosus neuropeptide s receptor 0.0534 0.2684 0.268
Trypanosoma cruzi hypothetical protein, conserved 0.0084 0.0353 0.6097
Trypanosoma brucei DNA polymerase IV, putative 0.0089 0.0376 0.6504
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0095 0.0079
Onchocerca volvulus Neuropeptide F receptor homolog 0.0022 0.003 0.0024
Schistosoma mansoni lamin 0.003 0.0072 0.0067
Plasmodium vivax amine transporter, putative 0.0331 0.1628 1
Brugia malayi G-protein coupled receptor 0.0022 0.003 0.003
Echinococcus granulosus tachykinin peptides receptor 99D 0.0022 0.003 0.0024
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0353 0.2141
Mycobacterium ulcerans DNA polymerase IV 0.0089 0.0376 0.0916
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0012 0.0006
Echinococcus multilocularis fmrfamide receptor 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0084 0.0353 0.0353
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0109 0.0256
Echinococcus granulosus Solute carrier family 22 5 0.1212 0.6191 0.6189
Loa Loa (eye worm) hypothetical protein 0.0084 0.0353 0.0353
Onchocerca volvulus 0.0022 0.003 0.0024
Onchocerca volvulus 0.0022 0.003 0.0024
Chlamydia trachomatis transglycolase/transpeptidase 0.0801 0.4063 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0575 0.1691
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.003 0.0024
Schistosoma mansoni flap endonuclease-1 0.0028 0.0059 0.0054
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.003 0.0024
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0016 0.0036
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.003 0.003
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0331 0.1628 0.1624
Echinococcus granulosus pyruvate kinase 0.0037 0.0109 0.0103
Echinococcus multilocularis 6 phosphofructokinase 0.0127 0.0575 0.057
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0036 0.0105 0.0238
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.003 0.0024
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0074 0.0424
Echinococcus granulosus somatostatin receptor 0.0022 0.003 0.0024
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0513 0.2574 0.9051
Onchocerca volvulus 0.0022 0.003 0.0024
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0025 0.0058
Echinococcus multilocularis g protein coupled receptor 0.0022 0.003 0.0024
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0031 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0024
Mycobacterium ulcerans endonuclease IV 0.0085 0.0359 0.0873
Treponema pallidum penicillin-binding protein (pbp-2) 0.0564 0.284 0.2829
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0331 0.1628 0.1624
Mycobacterium tuberculosis Probable oxidoreductase 0.014 0.0643 0.2265
Trichomonas vaginalis conserved hypothetical protein 0.0564 0.284 0.8413
Toxoplasma gondii thioredoxin reductase 0.0055 0.0203 0.1217
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0165 0.2798
Echinococcus granulosus geminin 0.0189 0.0894 0.0889
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0095 0.0194
Loa Loa (eye worm) hypothetical protein 0.0331 0.1628 0.1628
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.003 0.0024
Toxoplasma gondii peptidylprolyl isomerase 0.0036 0.0105 0.0611
Brugia malayi ORL1-like opioid receptor 0.0022 0.003 0.003
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0044 0.0142 0.0142
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0109 0.0367
Brugia malayi G protein-coupled receptor 0.0022 0.003 0.003
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0105 0.174
Onchocerca volvulus 0.0022 0.003 0.0024
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0331 0.1628 1
Treponema pallidum penicillin-binding protein (pbp-3) 0.0985 0.5018 0.501
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0248 0.0859
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Trypanosoma brucei unspecified product 0.0081 0.0338 0.5836
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0025 0.0025
Plasmodium falciparum flap endonuclease 1 0.003 0.0074 0.0424
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0031 0.0075
Loa Loa (eye worm) hypothetical protein 0.0034 0.0093 0.0093
Schistosoma mansoni DNA helicase recq1 0.0022 0.0031 0.0025
Echinococcus multilocularis allatostatin A receptor 0.0022 0.003 0.0024
Loa Loa (eye worm) RecQ helicase 0.0022 0.0031 0.0031
Giardia lamblia DNA damage repair protein 0.0018 0.0012 0.0018
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0031 0.0156
Mycobacterium tuberculosis Probable dehydrogenase 0.0126 0.057 0.2006
Treponema pallidum fructose-bisphosphate aldolase 0.0668 0.3375 0.3364
Echinococcus granulosus hypothetical protein 0.0022 0.003 0.0024
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0016 0.018
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0012 0.0037
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.003 0.0024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0025 0.0341
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0331 0.1628 0.1624
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0331 0.1628 0.1628
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.0376 0.6504
Onchocerca volvulus 0.0022 0.003 0.0024
Trypanosoma cruzi DNA polymerase eta, putative 0.0088 0.037 0.6391
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.003 0.0024
Schistosoma mansoni biogenic amine receptor 0.0022 0.003 0.0024
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0098 0.0092
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0006 0.0006
Onchocerca volvulus 0.003 0.0072 0.0067
Echinococcus granulosus orexin receptor type 2 0.0022 0.003 0.0024
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.003 0.0024
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0091 0.0085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.003 0.0024
Schistosoma mansoni DNA polymerase eta 0.0088 0.037 0.0364
Brugia malayi Sugar transporter family protein 0.0017 0.0006 0.0006
Trypanosoma brucei DNA polymerase IV, putative 0.0089 0.0376 0.6504
Echinococcus granulosus pyruvate kinase 0.0037 0.0109 0.0103
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Onchocerca volvulus 0.0331 0.1628 0.1624
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0159 0.2685
Brugia malayi major facilitator superfamily protein 0.0017 0.0006 0.0006
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0331 0.1628 1
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0564 0.284 0.7003
Giardia lamblia Fructose-bisphosphate aldolase 0.0668 0.3375 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0109 0.1815
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0059 0.0223 0.0217
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0109 0.0109
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0331 0.1628 0.1624
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0016 0.0025
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0127 0.0575 0.1933
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0016 0.0025
Leishmania major DNA polymerase kappa, putative 0.0066 0.0261 0.4479
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0159 0.0455
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.003 0.0024
Plasmodium vivax hypothetical protein, conserved 0.0331 0.1628 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.0376 0.6504
Loa Loa (eye worm) hypothetical protein 0.0085 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0025 0.012
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0331 0.1628 0.1624
Echinococcus multilocularis sodium and chloride dependent glycine 0.0331 0.1628 0.1624
Toxoplasma gondii exonuclease III APE 0.0021 0.0025 0.012
Loa Loa (eye worm) phosphofructokinase 0.0127 0.0575 0.0575
Brugia malayi Pre-SET motif family protein 0.0035 0.0098 0.0098
Trichomonas vaginalis D-aminoacylase, putative 0.0084 0.0353 0.1031
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0037 0.0109 0.0109
Schistosoma mansoni chromobox protein 0.0078 0.0319 0.0313
Brugia malayi follicle stimulating hormone receptor 0.0022 0.003 0.003
Schistosoma mansoni chromobox protein 0.0078 0.0319 0.0313
Mycobacterium tuberculosis Conserved protein 0.0084 0.0353 0.1234
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0025 0.0048
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.0376 0.6504
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0159 0.0153
Loa Loa (eye worm) hypothetical protein 0.0084 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.0331 0.1628 0.1628
Brugia malayi ImpB/MucB/SamB family protein 0.0088 0.037 0.037
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0015 0.006
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0025 0.0025
Schistosoma mansoni amine GPCR 0.0022 0.003 0.0024
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0186 0.0882 0.2165
Brugia malayi hypothetical protein 0.0022 0.003 0.003
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0022 0.0033 0.0033
Schistosoma mansoni rotamase 0.0037 0.0109 0.0104
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.0575 0.0575
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.003 0.0024
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0575 0.1691
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0012 0.0105
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.003 0.003
Brugia malayi Serotonin receptor 0.0022 0.003 0.003
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0137 0.0131
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0016 0.018
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0127 0.0575 0.056
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.003 0.0024
Toxoplasma gondii endonuclease IV APN 0.0085 0.0359 0.2177
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0036 0.0105 0.174
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0033 0.0067
Leishmania major DNA polymerase eta, putative 0.0088 0.037 0.6391
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0319 0.0929
Onchocerca volvulus 0.0331 0.1628 0.1624
Giardia lamblia Pyruvate kinase 0.0019 0.0015 0.0029
Plasmodium falciparum glutathione reductase 0.0019 0.0016 0.0063
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.0298 0.0813
Mycobacterium tuberculosis Probable lipase LipE 0.0084 0.0353 0.1234
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.003 0.0024
Brugia malayi chromobox protein homolog 3 0.0044 0.0142 0.0142
Trypanosoma cruzi DNA polymerase kappa, putative 0.0089 0.0376 0.6504
Leishmania major DNA damage repair protein, putative 0.0018 0.0012 0.0105
Schistosoma mansoni sodium/chloride dependent transporter 0.0331 0.1628 0.1624
Echinococcus multilocularis sodium and chloride dependent glycine 0.0331 0.1628 0.1624
Trypanosoma brucei DNA polymerase eta, putative 0.0088 0.037 0.6391
Onchocerca volvulus 0.0331 0.1628 0.1624
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.003 0.0024
Onchocerca volvulus 0.0277 0.1352 0.1347
Brugia malayi RE15519p 0.0022 0.003 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0668 0.3375 1
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.0799 0.4053 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0331 0.1628 0.1624
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.003 0.003
Echinococcus multilocularis pyruvate kinase 0.0037 0.0109 0.0103
Treponema pallidum hypothetical protein 0.0186 0.0882 0.0867
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0397 0.1972 0.6984
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0127 0.0575 0.2024
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0095 0.0548
Echinococcus multilocularis chromobox protein 1 0.0078 0.0319 0.0313
Onchocerca volvulus 0.0048 0.0163 0.0158
Chlamydia trachomatis transglycolase/transpeptidase 0.0395 0.1962 0.4807
Echinococcus granulosus beta LACTamase domain containing family member 0.0084 0.0353 0.0348
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0203 0.3467
Brugia malayi beta-lactamase 0.0084 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0016 0.0063
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0575 0.1691
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.003 0.0024
Schistosoma mansoni neuropeptide receptor 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Brugia malayi sulfakinin receptor protein 0.0022 0.003 0.003
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0331 0.1628 0.1628
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0098 0.0092
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0015 0.006
Onchocerca volvulus 0.0022 0.003 0.0024
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0331 0.1628 0.3984
Onchocerca volvulus 0.0084 0.0353 0.0348
Echinococcus multilocularis musashi 0.003 0.0072 0.0067
Echinococcus granulosus allatostatin A receptor 0.0022 0.003 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0016 0.018
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0022 0.003 0.0024
Echinococcus granulosus microtubule associated protein 2 0.1577 0.8081 0.808
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0012 0.0037
Trypanosoma brucei unspecified product 0.0041 0.0128 0.2143
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0095 0.0548
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.0376 0.6504
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0095 0.0548
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0025 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.0084 0.0353 0.1031
Schistosoma mansoni opsin-like receptor 0.0022 0.003 0.0024
Onchocerca volvulus 0.0022 0.003 0.0024
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0564 0.284 1
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0012 0.0105
Brugia malayi 6-phosphofructokinase 0.0127 0.0575 0.0575
Loa Loa (eye worm) glutathione reductase 0.0055 0.0203 0.0203
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.0298 0.0298
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.003 0.0024
Trichomonas vaginalis penicillin-binding protein, putative 0.0084 0.0353 0.1031
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.0223 0.0223
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0025 0.0019
Brugia malayi Heterochromatin protein 1 0.0078 0.0319 0.0319
Schistosoma mansoni neuropeptide receptor 0.0022 0.003 0.0024
Mycobacterium ulcerans lipase LipD 0.0084 0.0353 0.0858
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0031 0.0075
Brugia malayi 6-phosphofructokinase 0.0127 0.0575 0.0575
Loa Loa (eye worm) hypothetical protein 0.0022 0.0031 0.0031
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0561 0.2821 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.003 0.003
Schistosoma mansoni opsin-like receptor 0.0022 0.003 0.0024
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0109 0.1815
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0012 0.0105
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0225 0.0225
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.003 0.0024
Echinococcus granulosus fmrfamide receptor 0.0022 0.003 0.0024
Treponema pallidum penicillin-binding protein (pbp-1) 0.0801 0.4063 0.4054
Mycobacterium ulcerans hypothetical protein 0.0018 0.0012 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0084 0.0353 0.1031
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0016 0.003
Mycobacterium ulcerans esterase/lipase LipP 0.0084 0.0353 0.0858
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0024
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.003 0.0024
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0084 0.0353 0.0353
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0203 0.0198
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0025 0.0341
Schistosoma mansoni ap endonuclease 0.0021 0.0025 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Echinococcus multilocularis neuropeptide receptor 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Echinococcus granulosus g protein coupled receptor 0.0022 0.003 0.0024
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0016 0.018
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0105 0.174
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0031 0.0025
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0109 0.0103
Trypanosoma brucei trypanothione reductase 0.0055 0.0203 0.3467
Plasmodium falciparum thioredoxin reductase 0.0055 0.0203 0.1217
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0095 0.0194
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0031 0.0156
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0095 0.0548
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.003 0.0024
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0095 0.0264
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0006 0.0006
Trypanosoma brucei hypothetical protein, conserved 0.0084 0.0353 0.6097
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0031 0.0031
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0033 0.0027
Onchocerca volvulus 0.0022 0.003 0.0024
Echinococcus multilocularis neuropeptide receptor A26 0.0534 0.2684 0.268
Echinococcus granulosus flap endonuclease 1 0.003 0.0074 0.0069
Giardia lamblia Pyruvate kinase 0.0037 0.0109 0.0307
Brugia malayi G-protein coupled receptor 0.0022 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0331 0.1628 0.1628
Echinococcus granulosus sodium and chloride dependent glycine 0.0331 0.1628 0.1624
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0016 0.0063
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.014 0.0643 0.2175
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0326 0.1606 0.5684
Mycobacterium ulcerans 6-phosphofructokinase 0.0127 0.0575 0.1408
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0012 0.0105
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0331 0.1628 0.1628
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0076 0.0209
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0095 0.0264
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.003 0.003
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.003 0.003
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0095 0.0548
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0331 0.1628 0.1624
Brugia malayi neuropeptide F receptor 0.0022 0.003 0.003
Echinococcus granulosus lamin 0.003 0.0072 0.0067
Onchocerca volvulus 0.0022 0.003 0.0024
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0031 0.0156
Brugia malayi hypothetical protein 0.0331 0.1628 0.1628
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0098 0.0092
Echinococcus multilocularis microtubule associated protein 2 0.1577 0.8081 0.808
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0066 0.0261 0.4479
Plasmodium falciparum glutathione reductase 0.0055 0.0203 0.1217
Schistosoma mansoni lamin 0.003 0.0072 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0166 0.2811
Echinococcus multilocularis orexin receptor type 2 0.0022 0.003 0.0024
Brugia malayi Serotonin receptor 0.0022 0.003 0.003
Brugia malayi beta-lactamase family protein 0.0084 0.0353 0.0353
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0085 0.0359 0.2177
Trichomonas vaginalis rotamase, putative 0.0036 0.0105 0.0294
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0668 0.3375 1
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.0338 0.5836
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0016 0.001
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0074 0.0424
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.003 0.0024
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.003 0.0024
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.003 0.0024
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0668 0.3375 1
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.003 0.0024
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0016 0.018
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Giardia lamblia DINP protein human, muc B family 0.0066 0.0261 0.0758
Loa Loa (eye worm) hypothetical protein 0.0331 0.1628 0.1628
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0012 0.0037
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.014 0.0643 0.2265
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0668 0.3375 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0248 0.0598
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.003 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0109 0.0308
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.003 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0166 0.2811
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0025 0.012
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0109 0.0271
Loa Loa (eye worm) hypothetical protein 0.0035 0.0098 0.0098
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.0575 0.0575
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0189 0.0894 0.0889
Echinococcus multilocularis dna polymerase kappa 0.0089 0.0376 0.0371
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0016 0.0025
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.003 0.003
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0298 0.5122
Toxoplasma gondii hypothetical protein 0.0331 0.1628 1
Brugia malayi hypothetical protein 0.0022 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0126 0.057 0.1915
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0331 0.1628 0.1624
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0561 0.2821 0.6956
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0016 0.018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0016 0.018
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.003 0.0024
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.0298 0.0298
Mycobacterium tuberculosis Conserved hypothetical protein 0.0059 0.0223 0.0771
Brugia malayi major facilitator superfamily protein 0.0017 0.0006 0.0006
Onchocerca volvulus 0.0022 0.003 0.0024
Echinococcus granulosus neuropeptide receptor 0.0022 0.003 0.0024
Entamoeba histolytica Flap nuclease, putative 0.003 0.0074 0.0147
Entamoeba histolytica deoxycytidyl transferase, putative 0.0059 0.0223 0.059
Trichomonas vaginalis DNA polymerase eta, putative 0.0089 0.0376 0.11
Echinococcus multilocularis pyruvate kinase 0.0019 0.0015 0.001
Loa Loa (eye worm) hypothetical protein 0.0331 0.1628 0.1628
Trypanosoma brucei unspecified product 0.0041 0.0128 0.2143
Onchocerca volvulus 0.0022 0.003 0.0024
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0331 0.1628 1
Echinococcus multilocularis fmrfamide receptor 0.0022 0.003 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.0376 0.6504
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0006 0.0006
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0022 0.003 0.003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0089 0.0376 0.6504
Brugia malayi hypothetical protein 0.0022 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0248 0.0242
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0031 0.0444
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0084 0.0353 0.0348
Schistosoma mansoni neuropeptide receptor 0.0022 0.003 0.0024
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0098 0.0566
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0331 0.1628 0.1624
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0024
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0059 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0016 0.0063
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.003 0.0024
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.003 0.0024
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.0159 0.0943
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0095 0.0548
Echinococcus multilocularis expressed protein 0.0037 0.0109 0.0104
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0084 0.0353 0.0858
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0033 0.0097
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0006 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0668 0.3375 1
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.003 0.0024
Schistosoma mansoni hypothetical protein 0.0022 0.003 0.0024
Plasmodium falciparum pyruvate kinase 0.0037 0.0109 0.0637
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.0575 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0109 0.1815
Echinococcus multilocularis somatostatin receptor 0.0022 0.003 0.0024
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0074 0.1207
Plasmodium vivax glutathione reductase, putative 0.0055 0.0203 0.1217
Echinococcus multilocularis pyruvate kinase 0.0019 0.0015 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0089 0.0376 0.6504
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.003 0.0024
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0025 0.0069
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Schistosoma mansoni biogenic amine receptor 0.0022 0.003 0.0024
Onchocerca volvulus 0.0022 0.003 0.0024
Mycobacterium tuberculosis Conserved protein 0.0084 0.0353 0.1234
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0126 0.057 0.2006
Schistosoma mansoni amine GPCR 0.0022 0.003 0.0024
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.003 0.0024
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.003 0.0024
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.014 0.0643 0.2265
Trichomonas vaginalis esterase, putative 0.0084 0.0353 0.1031
Brugia malayi AKH receptor 0.0022 0.003 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0668 0.3375 1
Schistosoma mansoni adenoreceptor 0.0022 0.003 0.0024
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.0298 0.0292
Schistosoma mansoni biogenic amine receptor 0.0022 0.003 0.0024
Brugia malayi hypothetical protein 0.0022 0.003 0.003
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.003 0.0024
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0142 0.0136
Echinococcus multilocularis sex peptide receptor 0.0022 0.003 0.0024
Leishmania major DNA polymerase kappa, putative 0.0018 0.0012 0.0105
Schistosoma mansoni pyruvate kinase 0.0037 0.0109 0.0103
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0397 0.1972 0.4858
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0012 0.0105
Brugia malayi hypothetical protein 0.0022 0.003 0.003
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0137 0.0131
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0095 0.0264
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0016 0.0025
Echinococcus granulosus dna polymerase kappa 0.0089 0.0376 0.0371
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0085 0.0359 0.1255
Trypanosoma brucei DNA polymerase kappa, putative 0.0066 0.0261 0.4479
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0109 0.0637
Trichomonas vaginalis rotamase, putative 0.0037 0.0109 0.0308
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.003 0.0024
Schistosoma mansoni myosin xvIII 0.0022 0.003 0.0024
Brugia malayi intermediate filament protein 0.003 0.0072 0.0072
Echinococcus granulosus 6 phosphofructokinase 0.0127 0.0575 0.057
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0248 0.4246
Schistosoma mansoni pyruvate kinase 0.0037 0.0109 0.0103
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.003 0.0024
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0085 0.0359 0.1161
Loa Loa (eye worm) beta-lactamase 0.0084 0.0353 0.0353
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Echinococcus granulosus g protein coupled receptor 0.0022 0.003 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.0376 0.6504
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0016 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.0376 0.6504
Echinococcus multilocularis neuropeptide s receptor 0.0534 0.2684 0.268
Echinococcus multilocularis lamin dm0 0.003 0.0072 0.0067
Brugia malayi hypothetical protein 0.0022 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0142 0.0405
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0024
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.0319 0.0319
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0109 0.0109
Mycobacterium tuberculosis Conserved protein 0.0084 0.0353 0.1234
Loa Loa (eye worm) intermediate filament protein 0.003 0.0072 0.0072
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.019 0.0901 0.3179
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.003 0.0024
Schistosoma mansoni intermediate filament proteins 0.003 0.0072 0.0067
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0031 0.0031
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0025 0.0048
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0095 0.0264
Onchocerca volvulus 0.0034 0.0093 0.0088
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0031 0.0444
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0036 0.0105 0.174
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0024
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0016 0.003
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0095 0.0548
Loa Loa (eye worm) sugar transporter 0.0017 0.0006 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0024
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0012 0.0105
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0006 0.0006
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.003 0.0024
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0538 0.2705 0.9588
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.003 0.003
Onchocerca volvulus 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Mycobacterium ulcerans DNA polymerase IV 0.0089 0.0376 0.0916
Brugia malayi glutathione reductase 0.0055 0.0203 0.0203
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.003 0.0024
Echinococcus granulosus dna polymerase eta 0.0088 0.037 0.0364
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.003 0.0024
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0575 0.1643
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0031 0.0075
Brugia malayi Sugar transporter family protein 0.0017 0.0006 0.0006
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0074 0.0204
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0037 0.0109 0.0109
Schistosoma mansoni ap endonuclease 0.0021 0.0025 0.0019
Echinococcus multilocularis pyruvate kinase 0.0029 0.0069 0.0063
Mycobacterium ulcerans hypothetical protein 0.0084 0.0353 0.0858
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.02 0.0952 0.3274
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.003 0.0024
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0397 0.1972 0.6908
Echinococcus multilocularis geminin 0.0189 0.0894 0.0889
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.0575 0.057
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0084 0.0353 0.1234
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0015 0.006
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0575 0.1643
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0016 0.0063
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.003 0.003
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0059 0.0223 0.0217
Onchocerca volvulus 0.0022 0.003 0.0024
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0513 0.2574 0.9121
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0331 0.1628 0.1628
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0072 0.0072
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0575 0.1643
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.003 0.0024
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0331 0.1628 0.1624
Echinococcus granulosus bloom syndrome protein 0.0022 0.0031 0.0025
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.003 0.003
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0109 0.0307
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0331 0.1628 0.1628
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0298 0.5122
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0331 0.1628 0.1624
Leishmania major DNA polymerase eta, putative 0.0047 0.0159 0.2685
Loa Loa (eye worm) hypothetical protein 0.0048 0.0165 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0166 0.2811
Echinococcus multilocularis chromobox protein 1 0.0078 0.0319 0.0313
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0095 0.0264
Brugia malayi Flap endonuclease-1 0.003 0.0074 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0048 0.0163 0.0158
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0098 0.0092
Schistosoma mansoni hypothetical protein 0.0022 0.003 0.0024
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.003 0.0024
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.003 0.0024
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0016 0.018
Loa Loa (eye worm) sugar transporter 0.0017 0.0006 0.0006
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.0298 0.0292
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0109 0.0637
Schistosoma mansoni hypothetical protein 0.0022 0.003 0.0024
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0026 0.005 0.0271
Onchocerca volvulus 0.0022 0.003 0.0024
Echinococcus granulosus intermediate filament protein 0.003 0.0072 0.0067
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0016 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.0376 0.6504
Echinococcus granulosus expressed protein 0.0037 0.0109 0.0104
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0084 0.0353 0.0348
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0051 0.0051
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.0298 0.5122
Mycobacterium ulcerans beta-lactamase 0.0084 0.0353 0.0858
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.003 0.0024
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0248 0.0242
Loa Loa (eye worm) hypothetical protein 0.003 0.0072 0.0072
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0016 0.018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0016 0.018
Onchocerca volvulus 0.003 0.0072 0.0067
Schistosoma mansoni amine GPCR 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Echinococcus granulosus chromobox protein 1 0.0078 0.0319 0.0313
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.003 0.003
Mycobacterium ulcerans epimerase 0.0022 0.0033 0.0067
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0025 0.0058
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0031 0.0025
Brugia malayi Sugar transporter family protein 0.0017 0.0006 0.0006
Chlamydia trachomatis endonuclease IV 0.0085 0.0359 0.0847
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0088 0.037 0.037
Plasmodium vivax SET domain protein, putative 0.0035 0.0098 0.0566
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0668 0.3375 1
Mycobacterium leprae conserved hypothetical protein 0.0084 0.0353 0.1141
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Leishmania major pyruvate kinase 0.0037 0.0109 0.1815
Echinococcus granulosus chromobox protein 1 0.0078 0.0319 0.0313
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0298 0.5122
Brugia malayi hypothetical protein 0.0022 0.003 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.003 0.0024
Echinococcus multilocularis beta LACTamase domain containing family member 0.0084 0.0353 0.0348
Trichomonas vaginalis set domain proteins, putative 0.0277 0.1352 0.3997
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0016 0.018
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.0298 0.0292
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0331 0.1628 0.1624
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0126 0.057 0.2006
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0076 0.0209
Brugia malayi hypothetical protein 0.0022 0.003 0.003
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0095 0.0264
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.003 0.0024
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0016 0.018
Echinococcus granulosus pyruvate kinase 0.0019 0.0015 0.001
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.003 0.0024
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.003 0.0024
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.003 0.003
Trichomonas vaginalis penicillin-binding protein, putative 0.0084 0.0353 0.1031
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.02 0.0952 0.3361
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0085 0.0359 0.0359
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.003 0.0024
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0074 0.1207
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0668 0.3375 1
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0095 0.0207
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0095 0.0264
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.003 0.0024
Chlamydia trachomatis pyruvate kinase 0.0037 0.0109 0.023
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0084 0.0353 0.0353
Mycobacterium leprae Probable lipase LipE 0.0084 0.0353 0.1141
Mycobacterium tuberculosis Probable lipase LipD 0.0084 0.0353 0.1234
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.003 0.0024
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.003 0.0024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0025 0.0341
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0031 0.0031
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0074 0.0204
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0074 0.1207
Brugia malayi phosphofructokinase 0.0127 0.0575 0.0575
Leishmania major hypothetical protein, conserved 0.0084 0.0353 0.6097
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.003 0.0024
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.0575 0.057
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0331 0.1628 0.1624
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.0376 0.6504
Trypanosoma cruzi hypothetical protein, conserved 0.0084 0.0353 0.6097
Schistosoma mansoni histamine h1 receptor 0.0022 0.003 0.0024
Schistosoma mansoni neuropeptide receptor 0.0022 0.003 0.0024
Toxoplasma gondii ABC1 family protein 0.0084 0.0353 0.2141
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0319 0.0929
Mycobacterium tuberculosis Probable reductase 0.0126 0.057 0.2006
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Brugia malayi neuropeptide F receptor 0.0022 0.003 0.003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0066 0.0261 0.0907
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0186 0.0882 0.3024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.003 0.0024
Leishmania major ATP-dependent phosphofructokinase 0.0127 0.0575 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0248 0.0242
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0016 0.018
Echinococcus multilocularis pyruvate kinase 0.0019 0.0015 0.001
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0186 0.0882 0.3112
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0203 0.0203
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0084 0.0353 0.0353
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0109 0.1815
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.003 0.0024
Echinococcus multilocularis serotonin receptor 0.0022 0.003 0.0024
Echinococcus multilocularis pyruvate kinase 0.0037 0.0109 0.0103
Schistosoma mansoni opsin-like receptor 0.0022 0.003 0.0024
Echinococcus multilocularis g protein coupled receptor 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0165 0.2798
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0126 0.057 0.2006
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.003 0.0024
Brugia malayi hypothetical protein 0.0017 0.0006 0.0006
Schistosoma mansoni terminal deoxycytidyl transferase 0.0059 0.0223 0.0217
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0331 0.1628 0.1624
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0025 0.0058
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0109 0.0103
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Brugia malayi putative neuropeptide receptor 0.0022 0.003 0.003
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0331 0.1628 0.1624
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0109 0.0103
Mycobacterium tuberculosis Probable hydrolase 0.0084 0.0353 0.1234
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0109 0.0109
Echinococcus granulosus pyruvate kinase 0.0019 0.0015 0.001
Echinococcus multilocularis flap endonuclease 1 0.003 0.0074 0.0069
Brugia malayi Dopamine receptor protein 1 0.0022 0.003 0.003
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0326 0.1606 0.5604
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0244 0.1178 0.1178
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0051 0.0077
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0031 0.0025
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0012 0.0105
Echinococcus multilocularis neuropeptide receptor 0.0022 0.003 0.0024
Onchocerca volvulus 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.003 0.0024
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0016 0.018
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0203 0.0702
Brugia malayi larval opioid receptor 0.0022 0.003 0.003
Echinococcus granulosus neuropeptide receptor A26 0.0534 0.2684 0.268
Schistosoma mansoni microtubule-associated protein tau 0.1577 0.8081 0.808
Onchocerca volvulus 0.0084 0.0353 0.0348
Toxoplasma gondii hypothetical protein 0.0331 0.1628 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.0223 0.0217
Loa Loa (eye worm) hypothetical protein 0.0331 0.1628 0.1628
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0513 0.2574 0.6345
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0203 0.1217
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0084 0.0353 0.1234
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0159 0.0455
Plasmodium falciparum amino acid transporter, putative 0.0331 0.1628 1
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0012 0.0105
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0668 0.3375 1
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0069
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0089 0.0376 0.11
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0025 0.0009
Schistosoma mansoni DNA helicase recq5 0.0022 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0016 0.018
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0016 0.003
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Leishmania major pyruvate kinase 0.0037 0.0109 0.1815
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.003 0.0024
Mycobacterium ulcerans hypothetical protein 0.0022 0.0033 0.0067
Echinococcus multilocularis lamin 0.003 0.0072 0.0067
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0095 0.0264
Mycobacterium tuberculosis Probable esterase LipL 0.0084 0.0353 0.1234
Brugia malayi Pre-SET motif family protein 0.0244 0.1178 0.1178
Echinococcus granulosus g protein coupled receptor 0.0022 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0084 0.0353 0.0353
Brugia malayi beta-lactamase family protein 0.0084 0.0353 0.0353
Brugia malayi GnHR receptor homolog 0.0022 0.003 0.003
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.003 0.0024
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0031 0.0075
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.003 0.0024
Brugia malayi polk-prov protein 0.0048 0.0165 0.0165
Schistosoma mansoni sodium/chloride dependent transporter 0.0331 0.1628 0.1624
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.003 0.0024
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0085 0.0359 0.2177
Brugia malayi Thioredoxin reductase 0.0055 0.0203 0.0203
Echinococcus granulosus sex peptide receptor 0.0022 0.003 0.0024
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0033 0.0033
Brugia malayi Melatonin receptor type 1A 0.0022 0.003 0.003
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.0801 0.4063 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0109 0.0109
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.003 0.0024
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0109 0.0307
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0031 0.0031
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0031 0.0025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.003 0.0024
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0084 0.0353 0.1234
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0326 0.1606 0.3954
Schistosoma mansoni pyruvate kinase 0.0019 0.0015 0.001
Echinococcus granulosus lamin dm0 0.003 0.0072 0.0067
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0012 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0142 0.0405
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0126 0.057 0.2006
Brugia malayi Dopamine receptor protein 2 0.0022 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0189 0.0894 0.0889
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0575 0.1691
Echinococcus granulosus g-protein coupled receptor 0.0022 0.003 0.0024
Brugia malayi hypothetical protein 0.0022 0.003 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0098 0.0092
Echinococcus granulosus pyruvate kinase 0.0019 0.0015 0.001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0084 0.0353 0.0353
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0331 0.1628 0.1624
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0031 0.0444
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0331 0.1628 0.1628
Echinococcus multilocularis dna polymerase eta 0.0088 0.037 0.0364
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.003 0.0024
Schistosoma mansoni sodium-dependent amino acid transporter 0.0331 0.1628 0.1624
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0006
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.003 0.0024
Schistosoma mansoni amine GPCR 0.0022 0.003 0.0024
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.003 0.0024
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.003 0.0024
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.0575 1
Echinococcus granulosus neuropeptide receptor 0.0022 0.003 0.0024
Onchocerca volvulus 0.0022 0.003 0.0024
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.003 0.0024

Activities

Activity type Activity value Assay description Source Reference
Efficacy (functional) = 84 % Agonist activity at recombinant GABAA receptor subunit alpha-1 expressed in CHO cells at 3 uM by sensitive fluorometric read-out assay relative to midazolam ChEMBL. 21277199
Efficacy (functional) = 94 % Agonist activity at recombinant GABAA receptor subunit alpha-2 expressed in CHO cells at 3 uM by sensitive fluorometric read-out assay relative to midazolam ChEMBL. 21277199

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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