Detailed information for compound 1505173

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 306.365 | Formula: C17H18N6
  • H donors: 2 H acceptors: 3 LogP: 3.97 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNc1c(nc2n1cccn2)c1ccc2c(c1)cn[nH]2
  • InChi: 1S/C17H18N6/c1-2-3-7-18-16-15(21-17-19-8-4-9-23(16)17)12-5-6-14-13(10-12)11-20-22-14/h4-6,8-11,18H,2-3,7H2,1H3,(H,20,22)
  • InChiKey: ZAOAKWGRHJIYTD-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4 Starlite/ChEMBL No references
Homo sapiens CDC-like kinase 4 Starlite/ChEMBL No references
Homo sapiens cell division cycle 7 Starlite/ChEMBL No references
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens aurora kinase B Starlite/ChEMBL References
Homo sapiens homeodomain interacting protein kinase 2 Starlite/ChEMBL No references
Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha Starlite/ChEMBL No references
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL No references
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References
Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 4 Starlite/ChEMBL References
Homo sapiens interleukin-1 receptor-associated kinase 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Theileria parva cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Brugia malayi Homeodomain interacting protein kinase protein 1 Get druggable targets OG5_129272 All targets in OG5_129272
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis homeodomain interacting protein kinase 3 Get druggable targets OG5_129272 All targets in OG5_129272
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128641 All targets in OG5_128641
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania mexicana protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_129272 All targets in OG5_129272
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei protein kinase A catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CDC7 Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania infantum protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K02214 cell division control protein CDC7, putative Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus serine:threonine protein kinase mig 15 Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Theileria parva cAMP-dependent protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08826 homeodomain interacting protein kinase, putative Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania mexicana protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Mitogen-activated protein kinase kinase kinase kinase 4, putative Get druggable targets OG5_128641 All targets in OG5_128641
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi probable protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Candida albicans similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma japonicum Protein kinase DC2, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum IPR000437,Prokaryotic membrane lipoprotein lipid attachment site,domain-containing Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus homeodomain interacting protein kinase 3 Get druggable targets OG5_129272 All targets in OG5_129272
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium knowlesi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi serine/threonine-protein kinase PAK 7 Get druggable targets OG5_131977 All targets in OG5_131977
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Candida albicans hypothetical protein Get druggable targets OG5_129272 All targets in OG5_129272
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) STE/STE20/PAKB protein kinase Get druggable targets OG5_131977 All targets in OG5_131977
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) STE/STE20/MSN protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CDC7 protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum expressed protein Get druggable targets OG5_129272 All targets in OG5_129272
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Echinococcus multilocularis CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania major protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium hominis protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium berghei cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus aurora kinase A 0.0073 0.1086 0.2995
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0063 0.0897 0.2363
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0024 0.0177 0.0346
Giardia lamblia Aurora kinase 0.0073 0.1086 0.9087
Trichomonas vaginalis STE family protein kinase 0.0024 0.0177 0.094
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0787 0.6466
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0063 0.0897 0.2476
Brugia malayi Protein kinase domain containing protein 0.0057 0.0787 0.0719
Plasmodium falciparum protein kinase 5 0.0057 0.0787 0.1423
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0197 0.3403 0.3403
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0054 0.0722 0.489
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0019 0.0073 0.0056
Brugia malayi serine/threonine kinase 12 0.0073 0.1086 0.102
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0019 0.0073 0.0202
Echinococcus multilocularis PAK box P21 Rho binding 0.0024 0.0177 0.0346
Entamoeba histolytica PH domain containing protein kinase, putative 0.0054 0.0722 0.1827
Brugia malayi intracellular kinase 0.0063 0.0897 0.083
Echinococcus multilocularis rho associated protein kinase 0.0181 0.3096 0.8522
Entamoeba histolytica protein kinase, putative 0.0024 0.0177 0.0292
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.1086 0.2995
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.003 0.0287 0.0792
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0036 0.0391 0.0945
Entamoeba histolytica PH domain containing protein kinase, putative 0.0054 0.0722 0.1827
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0073 0.1086 0.7992
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0197 0.3403 0.3403
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0036 0.0391 0.1079
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0722 0.1993
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0063 0.0897 0.6859
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0054 0.0722 0.489
Entamoeba histolytica cell division protein kinase 2, putative 0.0057 0.0787 0.201
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0054 0.0722 0.489
Plasmodium falciparum protein serine/threonine kinase-1 0.0078 0.1177 1
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0024 0.0177 0.0346
Entamoeba histolytica protein kinase domain containing protein 0.0063 0.0897 0.2321
Trypanosoma cruzi aurora B kinase, putative 0.0073 0.1086 0.8974
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.003 0.0287 0.0654
Loa Loa (eye worm) AUR protein kinase 0.0073 0.1086 0.1086
Entamoeba histolytica protein kinase , putative 0.0073 0.1086 0.2851
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0073 0.1086 0.2995
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0054 0.0722 0.1993
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.1098 0.9283
Schistosoma mansoni hypothetical protein 0.0019 0.0073 0.0202
Echinococcus granulosus dual specificity protein kinase clk2 0.0078 0.1177 0.3247
Trypanosoma cruzi cdc2-related kinase 3 0.0057 0.0787 0.5617
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0207 0.3581 0.9882
Trypanosoma brucei cdc2-related kinase 3 0.0057 0.0787 0.5617
Brugia malayi Protein kinase domain containing protein 0.0078 0.1177 0.1112
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.1177 0.3247
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0057 0.0787 0.1423
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0024 0.0177 0.0489
Entamoeba histolytica p21-activated kinase 0.0024 0.0177 0.0292
Brugia malayi Protein kinase domain containing protein 0.0197 0.3403 0.3355
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.3096 0.8544
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0057 0.0787 0.1423
Onchocerca volvulus 0.0074 0.1098 0.2601
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0057 0.0787 0.0787
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0078 0.1177 1
Giardia lamblia Kinase, CMGC GSK 0.0063 0.0897 0.7204
Schistosoma mansoni protein kinase 0.0078 0.1171 0.3232
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0722 0.588
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.1086 0.2851
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0197 0.3403 1
Onchocerca volvulus 0.0175 0.2992 0.8682
Echinococcus multilocularis protein kinase shaggy 0.0063 0.0897 0.2363
Entamoeba histolytica cell division protein kinase 2, putative 0.0057 0.0787 0.201
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0054 0.0722 0.489
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0207 0.3581 0.9881
Brugia malayi Protein kinase domain 0.0024 0.0177 0.0105
Trypanosoma brucei protein kinase, putative 0.0063 0.0897 0.6859
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0036 0.0391 0.0391
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0054 0.0722 0.489
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0019 0.0073 0.0202
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0722 0.1993
Giardia lamblia Kinase, CDC7 0.0074 0.1098 0.9208
Echinococcus multilocularis PAK box P21 Rho binding 0.0019 0.0073 0.0056
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0054 0.0722 0.1873
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0209 0.3624 0.3577
Echinococcus granulosus cyclin dependent kinase 1 0.0057 0.0787 0.2171
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0209 0.3624 1
Onchocerca volvulus 0.0063 0.0897 0.1958
Giardia lamblia Kinase, AGC PKA 0.0054 0.0722 0.5453
Echinococcus granulosus twitchin 0.002 0.0089 0.0246
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0209 0.3624 1
Onchocerca volvulus 0.0074 0.1098 0.2601
Giardia lamblia Kinase, CMGC CDK 0.0057 0.0787 0.61
Trypanosoma cruzi cdc2-related kinase 3 0.0057 0.0787 0.5617
Echinococcus granulosus cyclin dependent kinase 5 0.0057 0.0787 0.2171
Loa Loa (eye worm) CDC7 protein kinase 0.0074 0.1098 0.1098
Plasmodium vivax serine/threonine kinase-1, putative 0.0078 0.1177 1
Onchocerca volvulus 0.0181 0.3096 0.9015
Schistosoma mansoni hypothetical protein 0.0019 0.0073 0.0202
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0897 0.7467
Schistosoma mansoni serine/threonine protein kinase 0.0209 0.3624 1
Entamoeba histolytica protein kinase domain containing protein 0.0063 0.0897 0.2321
Echinococcus multilocularis aurora kinase A 0.0073 0.1086 0.289
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.1098 0.9283
Schistosoma mansoni hypothetical protein 0.003 0.0287 0.0792
Trichomonas vaginalis STE family protein kinase 0.0024 0.0177 0.094
Echinococcus multilocularis 0.0072 0.1073 0.2855
Plasmodium vivax protein kinase Crk2 0.0057 0.0787 0.1423
Brugia malayi probable protein kinase 0.0108 0.1736 0.1675
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0287
Schistosoma mansoni vam6/vps39 related 0.003 0.0287 0.0792
Loa Loa (eye worm) hypothetical protein 0.0054 0.0722 0.0722
Trichomonas vaginalis CMGC family protein kinase 0.0078 0.1177 1
Trichomonas vaginalis AGC family protein kinase 0.0073 0.1086 0.9173
Echinococcus multilocularis dual specificity protein kinase clk2 0.0078 0.1177 0.3146
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0053
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0073 0.1086 0.2851
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0197 0.3403 0.9382
Trichomonas vaginalis STE family protein kinase 0.0024 0.0177 0.094
Schistosoma mansoni tyrosine kinase 0.0022 0.014 0.0386
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0057 0.0787 0.2171
Echinococcus granulosus protein kinase 0.0078 0.1171 0.3232
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0036 0.0391 0.0945
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0019 0.0073 0.0202
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0063 0.0897 0.0897
Brugia malayi cell division control protein 2 homolog 0.0057 0.0787 0.0719
Plasmodium falciparum serine/threonine protein kinase, putative 0.0073 0.1086 0.7992
Brugia malayi Temporarily assigned gene name protein 59 0.003 0.0287 0.0215
Brugia malayi Protein kinase domain containing protein 0.0074 0.1098 0.1032
Echinococcus granulosus protein kinase shaggy 0.0063 0.0897 0.2476
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0287
Toxoplasma gondii aurora kinase 0.0073 0.1086 0.7992
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0078 0.1177 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0036 0.0391 0.0945
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0078 0.1171 0.1171
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0078 0.1177 1
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0722 0.1993
Echinococcus granulosus hypothetical protein 0.0072 0.1073 0.2961
Leishmania major protein kinase, putative 0.0078 0.1177 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1073 0.1073
Trypanosoma brucei aurora B kinase 0.0073 0.1086 0.8974
Trichomonas vaginalis STE family protein kinase 0.0024 0.0177 0.094
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.003 0.0287 0.0792
Echinococcus multilocularis CDC7 cell division cycle 7 0.0074 0.1098 0.2924
Entamoeba histolytica protein kinase, putative 0.0063 0.0897 0.2321
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0073 0.1086 0.289
Echinococcus multilocularis cyclin dependent kinase 1 0.0057 0.0787 0.2054
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.0897 0.7467
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0057 0.0787 0.0787
Trichomonas vaginalis STE family protein kinase 0.0024 0.0177 0.094
Schistosoma mansoni protein kinase 0.0019 0.0073 0.0202
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0063 0.0897 0.3852
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0073
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0078 0.1177 1
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0019 0.0073 0.0073
Echinococcus granulosus roundabout 2 0.0018 0.0053 0.0148
Leishmania major protein kinase, putative 0.0073 0.1086 0.7992
Onchocerca volvulus 0.0167 0.2829 0.8157
Giardia lamblia Kinase, CMGC CDK 0.0057 0.0787 0.61
Trichomonas vaginalis AGC family protein kinase 0.0073 0.1086 0.9173
Entamoeba histolytica protein kinase, putative 0.0024 0.0177 0.0292
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0102 0.1632 0.4504
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0048 0.0618 0.1582
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.003 0.0287 0.0792
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0024 0.0177 0.0489
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0048 0.0618 0.1706
Echinococcus multilocularis cyclin dependent kinase 5 0.0057 0.0787 0.2054
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0787 0.6466
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0287
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0054 0.0722 0.1993
Schistosoma mansoni hypothetical protein 0.0019 0.0073 0.0202
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0078 0.1177 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0063 0.0897 0.2476
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.1098 0.9283
Giardia lamblia Kinase, CMGC GSK 0.0063 0.0897 0.7204
Loa Loa (eye worm) hypothetical protein 0.0102 0.1632 0.1632
Brugia malayi serine/threonine protein kinase 6 0.0073 0.1086 0.102
Entamoeba histolytica protein kinase, putative 0.0073 0.1086 0.2851
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0078 0.1177 1
Trichomonas vaginalis AGC family protein kinase 0.0073 0.1086 0.9173
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0197 0.3403 0.9391
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0078 0.1177 1
Loa Loa (eye worm) AUR protein kinase 0.0073 0.1086 0.1086
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0054 0.0722 0.0654
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0036 0.0391 0.1079
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0054 0.0722 0.489
Brugia malayi hypothetical protein 0.003 0.0287 0.0215
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0054 0.0722 0.1873
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0063 0.0897 0.0897
Schistosoma mansoni protein kinase 0.0024 0.0177 0.0489
Brugia malayi Protein kinase domain containing protein 0.0036 0.0391 0.032
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0197 0.3403 0.3355
Echinococcus multilocularis 0.0078 0.1171 0.313
Entamoeba histolytica protein kinase, putative 0.0024 0.0177 0.0292
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0024 0.0177 0.0346
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0053
Plasmodium falciparum glycogen synthase kinase 3 0.0063 0.0897 0.3852
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0185 0.3173 0.3173
Trypanosoma brucei cdc2-related kinase 1 0.0057 0.0787 0.5617
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0054 0.0722 0.1873
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0787 0.6466
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.1177 0.3247
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0787 0.2171
Entamoeba histolytica protein kinase, putative 0.0073 0.1086 0.2851
Giardia lamblia Kinase, CMGC CLK 0.0078 0.1177 1
Onchocerca volvulus Tyrosine kinase homolog 0.0173 0.2949 0.8542
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0391 0.1079
Plasmodium vivax glycogen synthase kinase 3, putative 0.0063 0.0897 0.3852
Trypanosoma cruzi cdc2-related kinase 1 0.0057 0.0787 0.5617
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0209 0.3624 0.3624
Entamoeba histolytica protein kinase domain containing protein 0.0209 0.3624 1
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0787 0.2171
Echinococcus granulosus rho-associated protein kinase 1 0.0181 0.3096 0.8544
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0024 0.0177 0.0489
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0226 0.3933 0.3933
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.014 0.0386
Schistosoma mansoni protein kinase 0.0024 0.0177 0.0489
Echinococcus granulosus cyclin dependent kinase 0.0057 0.0787 0.2171
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0073 0.1086 0.2851
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0391 0.1079
Brugia malayi serine/threonine-protein kinase PAK 7 0.0226 0.3933 0.3888
Trichomonas vaginalis AGC family protein kinase 0.0073 0.1086 0.9173
Echinococcus multilocularis cyclin dependent kinase 0.0057 0.0787 0.2054
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0054 0.0722 0.1873
Entamoeba histolytica protein kinase, putative 0.0024 0.0177 0.0292
Loa Loa (eye worm) hypothetical protein 0.0052 0.0683 0.0683
Echinococcus granulosus PAK box P21 Rho binding 0.0019 0.0073 0.0202
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.3403 0.9391
Echinococcus granulosus Vam6:Vps39 protein 0.003 0.0287 0.0792
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0078 0.1177 0.1177
Loa Loa (eye worm) AGC/PKA protein kinase 0.0054 0.0722 0.0722
Schistosoma mansoni protein kinase 0.0108 0.1736 0.479
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0054 0.0722 0.489
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0054 0.0722 0.1993
Schistosoma mansoni protein kinase 0.0073 0.1086 0.2995
Schistosoma mansoni protein kinase 0.0024 0.0177 0.0489
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0073 0.1086 0.2851
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.1098 0.3029
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0063 0.0897 0.3852
Brugia malayi Immunoglobulin I-set domain containing protein 0.0185 0.3173 0.3123
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0057 0.0787 0.0787
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0057 0.0787 0.1423
Loa Loa (eye worm) AUR protein kinase 0.0073 0.1086 0.1086
Trypanosoma cruzi cdc2-related kinase 1 0.0057 0.0787 0.5617
Loa Loa (eye worm) AGC/PKA protein kinase 0.0054 0.0722 0.0722
Schistosoma mansoni rap gtpase-activating protein 0.003 0.0287 0.0792
Schistosoma mansoni protein kinase 0.0036 0.0391 0.1079
Echinococcus granulosus CDC7 cell division cycle 7 0.0074 0.1098 0.3029
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0036 0.0391 0.1079
Echinococcus multilocularis cyclin dependent kinase 1 0.0057 0.0787 0.2054
Brugia malayi serine/threonine-protein kinase 6 0.0073 0.1086 0.102
Leishmania major protein kinase, putative 0.0078 0.1177 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) Inhibition of JAK2 ChEMBL. 21288717
Ki (functional) > 5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: IRAK4 ChEMBL. No reference
Ki (functional) = 5.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP4K4 ChEMBL. No reference
Ki (functional) = 6 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKACA ChEMBL. No reference
Ki (functional) = 6.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PIM1 ChEMBL. No reference
Ki (functional) = 6.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK2 ChEMBL. No reference
Ki (functional) = 7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: HIPK2 ChEMBL. No reference
Ki (functional) = 7.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ROCK2 ChEMBL. No reference
Ki (functional) = 7.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: GSK3B ChEMBL. No reference
Ki (functional) = 8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDC7 ChEMBL. No reference
Ki (functional) = 8.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CLK4 ChEMBL. No reference
Ki (binding) = 0.019 uM Inhibition of GSK3-beta ChEMBL. 21288717
Ki (binding) = 0.114 uM Inhibition of Pim1 ChEMBL. 21288717
Ki (binding) = 0.116 uM Inhibition of Rock2 ChEMBL. 21288717
Ki (binding) > 3.75 uM Inhibition of Pak4 ChEMBL. 21288717
Ki (binding) > 4.9 uM Inhibition of aurora 2 ChEMBL. 21288717
Ki (binding) > 8.88 uM Inhibition of KDR ChEMBL. 21288717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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