Detailed information for compound 1506277

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 290.319 | Formula: C17H14N4O
  • H donors: 2 H acceptors: 2 LogP: 3.27 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1n[nH]c2c1cc(cc2)c1onc(c1)Cc1ccccc1
  • InChi: 1S/C17H14N4O/c18-17-14-9-12(6-7-15(14)19-20-17)16-10-13(21-22-16)8-11-4-2-1-3-5-11/h1-7,9-10H,8H2,(H3,18,19,20)
  • InChiKey: XFHCSNRQFQRLHZ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL No references
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 4 Starlite/ChEMBL References
Homo sapiens aurora kinase B Starlite/ChEMBL References
Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4 Starlite/ChEMBL No references
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens Janus kinase 2 Starlite/ChEMBL References
Homo sapiens homeodomain interacting protein kinase 2 Starlite/ChEMBL No references
Homo sapiens CDC-like kinase 4 Starlite/ChEMBL No references
Homo sapiens MAP kinase interacting serine/threonine kinase 2 Starlite/ChEMBL No references
Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha Starlite/ChEMBL No references
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL References
Homo sapiens interleukin-1 receptor-associated kinase 4 Starlite/ChEMBL No references
Homo sapiens cell division cycle 7 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase Get druggable targets OG5_131958 All targets in OG5_131958
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Leishmania mexicana protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR000437,Prokaryotic membrane lipoprotein lipid attachment site,domain-containing Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131958 All targets in OG5_131958
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Echinococcus granulosus serine:threonine protein kinase mig 15 Get druggable targets OG5_128641 All targets in OG5_128641
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma japonicum Protein kinase DC2, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129189 All targets in OG5_129189
Loa Loa (eye worm) STE/STE20/MSN protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma japonicum Mitogen-activated protein kinase kinase kinase kinase 4, putative Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Homeodomain interacting protein kinase protein 1 Get druggable targets OG5_129272 All targets in OG5_129272
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Brugia malayi probable protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva cAMP-dependent protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128641 All targets in OG5_128641
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K08826 homeodomain interacting protein kinase, putative Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma japonicum ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative Get druggable targets OG5_128641 All targets in OG5_128641
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Theileria parva cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus homeodomain interacting protein kinase 3 Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus granulosus enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Echinococcus multilocularis serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania braziliensis protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02214 cell division control protein CDC7, putative Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CDC7 Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum expressed protein Get druggable targets OG5_129272 All targets in OG5_129272
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_129272 All targets in OG5_129272
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus granulosus serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Trypanosoma brucei protein kinase A catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CDC7 protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus granulosus CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi serine/threonine-protein kinase PAK 7 Get druggable targets OG5_131977 All targets in OG5_131977
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_129272 All targets in OG5_129272
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans hypothetical protein Get druggable targets OG5_129272 All targets in OG5_129272
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) STE/STE20/PAKB protein kinase Get druggable targets OG5_131977 All targets in OG5_131977
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis homeodomain interacting protein kinase 3 Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0102 0.1631 0.4491
Loa Loa (eye worm) hypothetical protein 0.0072 0.1072 0.1072
Echinococcus multilocularis PAK box P21 Rho binding 0.0019 0.0073 0.0055
Schistosoma mansoni hypothetical protein 0.0019 0.0073 0.0202
Giardia lamblia Kinase, CDC7 0.0074 0.1107 0.9208
Schistosoma mansoni protein kinase 0.0019 0.0073 0.0202
Plasmodium falciparum glycogen synthase kinase 3 0.0064 0.0907 0.3852
Brugia malayi Protein kinase domain containing protein 0.0058 0.0796 0.0728
Trichomonas vaginalis STE family protein kinase 0.0025 0.0187 0.1025
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0019 0.0073 0.0202
Brugia malayi Protein kinase domain 0.0025 0.0187 0.0115
Brugia malayi Temporarily assigned gene name protein 59 0.003 0.0287 0.0215
Loa Loa (eye worm) AGC/PKA protein kinase 0.0054 0.0732 0.0732
Schistosoma mansoni protein kinase 0.0109 0.1745 0.4805
Entamoeba histolytica protein kinase , putative 0.0074 0.1095 0.2871
Echinococcus granulosus tyrosine protein kinase Lyn 0.0017 0.0048 0.0131
Brugia malayi cell division control protein 2 homolog 0.0058 0.0796 0.0728
Onchocerca volvulus Tyrosine kinase homolog 0.0175 0.2978 0.8615
Echinococcus multilocularis dual specificity protein kinase clk2 0.0079 0.1186 0.3166
Echinococcus granulosus protein kinase 0.0078 0.118 0.3251
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.1186 0.3266
Schistosoma mansoni protein kinase 0.0036 0.0401 0.1104
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0074 0.1095 0.7992
Echinococcus granulosus Vam6:Vps39 protein 0.003 0.0287 0.079
Trichomonas vaginalis AGC family protein kinase 0.0074 0.1095 0.9181
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0287
Schistosoma mansoni protein kinase 0.0025 0.0187 0.0516
Trypanosoma brucei cdc2-related kinase 1 0.0058 0.0796 0.5668
Trichomonas vaginalis AGC family protein kinase 0.0074 0.1095 0.9181
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0064 0.0907 0.0907
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0054 0.0732 0.2016
Echinococcus multilocularis 0.0072 0.1072 0.2847
Plasmodium falciparum protein serine/threonine kinase-1 0.0079 0.1186 1
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0074 0.1095 0.2911
Brugia malayi Protein kinase domain containing protein 0.0074 0.1107 0.1041
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0732 0.5919
Leishmania major protein kinase, putative 0.0074 0.1095 0.7992
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0036 0.0401 0.0971
Loa Loa (eye worm) AGC/PKA protein kinase 0.0054 0.0732 0.0732
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0054 0.0732 0.0663
Brugia malayi Protein kinase domain containing protein 0.0036 0.0401 0.033
Entamoeba histolytica protein kinase, putative 0.0025 0.0187 0.0321
Entamoeba histolytica p21-activated kinase 0.0025 0.0187 0.0321
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0064 0.0907 0.3852
Schistosoma mansoni protein kinase 0.0025 0.0187 0.0516
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0079 0.1186 1
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.341 0.9393
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0401 0.1104
Echinococcus granulosus twitchin 0.002 0.0099 0.0273
Giardia lamblia Kinase, AGC PKA 0.0054 0.0732 0.5453
Schistosoma mansoni rap gtpase-activating protein 0.003 0.0287 0.079
Plasmodium falciparum serine/threonine protein kinase, putative 0.0074 0.1095 0.7992
Entamoeba histolytica protein kinase domain containing protein 0.0064 0.0907 0.2343
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0079 0.1186 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0682 0.0682
Trichomonas vaginalis STE family protein kinase 0.0025 0.0187 0.1025
Echinococcus multilocularis cyclin dependent kinase 1 0.0058 0.0796 0.2077
Trypanosoma brucei cdc2-related kinase 3 0.0058 0.0796 0.5668
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0078 0.118 0.118
Loa Loa (eye worm) hypothetical protein 0.0102 0.1631 0.1631
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0198 0.341 0.341
Toxoplasma gondii aurora kinase 0.0074 0.1095 0.7992
Brugia malayi probable protein kinase 0.0109 0.1745 0.1684
Echinococcus granulosus aurora kinase A 0.0074 0.1095 0.3015
Plasmodium vivax glycogen synthase kinase 3, putative 0.0064 0.0907 0.3852
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.1107 0.9289
Entamoeba histolytica protein kinase, putative 0.0025 0.0187 0.0321
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0025 0.0187 0.0374
Echinococcus multilocularis aurora kinase A 0.0074 0.1095 0.2911
Entamoeba histolytica protein kinase domain containing protein 0.0074 0.1095 0.2871
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0036 0.0401 0.0971
Echinococcus multilocularis cyclin dependent kinase 1 0.0058 0.0796 0.2077
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0505 0.913 0.913
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.3103 0.8548
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0287
Brugia malayi Protein kinase domain containing protein 0.0505 0.913 0.9124
Schistosoma mansoni hypothetical protein 0.0019 0.0073 0.0202
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0198 0.341 0.9384
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0064 0.0907 0.0907
Trichomonas vaginalis STE family protein kinase 0.0025 0.0187 0.1025
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0054 0.0732 0.4949
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0054 0.0732 0.4949
Brugia malayi serine/threonine protein kinase 6 0.0074 0.1095 0.1029
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.1186 1
Onchocerca volvulus 0.0182 0.3103 0.9018
Trypanosoma cruzi cdc2-related kinase 1 0.0058 0.0796 0.5668
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.1186 0.3266
Giardia lamblia Kinase, CMGC CDK 0.0058 0.0796 0.61
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0048 0.0618 0.1578
Trypanosoma brucei protein kinase, putative 0.0064 0.0907 0.6895
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0198 0.341 0.3362
Giardia lamblia Kinase, CMGC GSK 0.0064 0.0907 0.7204
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0053
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0796 0.2194
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0054 0.0732 0.1896
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0058 0.0796 0.0796
Brugia malayi serine/threonine-protein kinase PAK 7 0.0226 0.3939 0.3894
Echinococcus multilocularis cyclin dependent kinase 0.0058 0.0796 0.2077
Brugia malayi Homeodomain interacting protein kinase protein 1 0.021 0.3631 0.3584
Brugia malayi serine/threonine-protein kinase 6 0.0074 0.1095 0.1029
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0058 0.0796 0.0796
Trypanosoma cruzi cdc2-related kinase 3 0.0058 0.0796 0.5668
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0036 0.0401 0.0401
Entamoeba histolytica cell division protein kinase 2, putative 0.0058 0.0796 0.2033
Brugia malayi Protein kinase domain containing protein 0.0198 0.341 0.3362
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0064 0.0907 0.6895
Brugia malayi serine/threonine kinase 12 0.0074 0.1095 0.1029
Leishmania major protein kinase, putative 0.0079 0.1186 1
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0401 0.1104
Echinococcus multilocularis CDC7 cell division cycle 7 0.0074 0.1107 0.2945
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0036 0.0401 0.1104
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0058 0.0796 0.1423
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0732 0.2016
Onchocerca volvulus 0.0175 0.2989 0.8653
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0054 0.0732 0.2016
Plasmodium vivax serine/threonine kinase-1, putative 0.0079 0.1186 1
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.003 0.0287 0.079
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0054 0.0732 0.1896
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0074 0.1095 0.2871
Brugia malayi intracellular kinase 0.0064 0.0907 0.084
Schistosoma mansoni protein kinase 0.0078 0.118 0.3251
Entamoeba histolytica protein kinase, putative 0.0025 0.0187 0.0321
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.1107 0.9289
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0054 0.0732 0.2016
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0048 0.0618 0.1702
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.1095 0.3015
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0208 0.3588 0.9881
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0025 0.0187 0.0374
Onchocerca volvulus 0.0074 0.1107 0.2626
Brugia malayi Immunoglobulin I-set domain containing protein 0.0187 0.3202 0.3152
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0036 0.0401 0.0971
Schistosoma mansoni vam6/vps39 related 0.003 0.0287 0.079
Entamoeba histolytica PH domain containing protein kinase, putative 0.0054 0.0732 0.1851
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0054 0.0732 0.1896
Echinococcus multilocularis cyclin dependent kinase 5 0.0058 0.0796 0.2077
Brugia malayi Protein kinase domain containing protein 0.0079 0.1186 0.1121
Echinococcus multilocularis protein kinase shaggy 0.0064 0.0907 0.2385
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0054 0.0732 0.4949
Plasmodium vivax protein kinase Crk2 0.0058 0.0796 0.1423
Giardia lamblia Kinase, CMGC GSK 0.0064 0.0907 0.7204
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0058 0.0796 0.1423
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0198 0.341 0.341
Entamoeba histolytica protein kinase, putative 0.0074 0.1095 0.2871
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0064 0.0907 0.2498
Trypanosoma cruzi cdc2-related kinase 1 0.0058 0.0796 0.5668
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.1107 0.9289
Trichomonas vaginalis STE family protein kinase 0.0025 0.0187 0.1025
Schistosoma mansoni protein kinase 0.0025 0.0187 0.0516
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0025 0.0187 0.0516
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0074 0.1095 0.2871
Echinococcus granulosus PAK box P21 Rho binding 0.0019 0.0073 0.0202
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0064 0.0907 0.2385
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0054 0.0732 0.1896
Entamoeba histolytica PH domain containing protein kinase, putative 0.0054 0.0732 0.1851
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0019 0.0073 0.0202
Echinococcus granulosus rho-associated protein kinase 1 0.0182 0.3103 0.8548
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0796 0.2194
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0198 0.341 1
Giardia lamblia Kinase, CMGC CDK 0.0058 0.0796 0.61
Echinococcus granulosus CDC7 cell division cycle 7 0.0074 0.1107 0.3049
Echinococcus granulosus cyclin dependent kinase 5 0.0058 0.0796 0.2194
Echinococcus multilocularis PAK box P21 Rho binding 0.0025 0.0187 0.0374
Trichomonas vaginalis STE family protein kinase 0.0025 0.0187 0.1025
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0208 0.3588 0.9883
Schistosoma mansoni protein kinase 0.0074 0.1095 0.3015
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0058 0.0796 0.0796
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0064 0.0907 0.3852
Echinococcus granulosus roundabout 2 0.0018 0.0053 0.0147
Echinococcus multilocularis rho associated protein kinase 0.0182 0.3103 0.8526
Echinococcus granulosus dual specificity protein kinase clk2 0.0079 0.1186 0.3266
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0732 0.2016
Trichomonas vaginalis CMGC family protein kinase 0.0064 0.0907 0.7491
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0079 0.1186 1
Entamoeba histolytica protein kinase, putative 0.0074 0.1095 0.2871
Onchocerca volvulus 0.0074 0.1107 0.2626
Leishmania major protein kinase, putative 0.0079 0.1186 1
Loa Loa (eye worm) AUR protein kinase 0.0074 0.1095 0.1095
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0019 0.0073 0.0073
Trypanosoma brucei aurora B kinase 0.0074 0.1095 0.8986
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0054 0.0732 0.4949
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0025 0.0187 0.0374
Loa Loa (eye worm) AUR protein kinase 0.0074 0.1095 0.1095
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.003 0.0287 0.079
Entamoeba histolytica protein kinase, putative 0.0064 0.0907 0.2343
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0079 0.1186 1
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0079 0.1186 1
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0796 0.6499
Schistosoma mansoni serine/threonine protein kinase 0.021 0.3631 1
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0058 0.0796 0.2194
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0796 0.6499
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.1107 0.3049
Entamoeba histolytica cell division protein kinase 2, putative 0.0058 0.0796 0.2033
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0054 0.0732 0.4949
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0172 0.0472
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.021 0.3631 0.3631
Schistosoma mansoni tyrosine kinase 0.0024 0.0172 0.0472
Onchocerca volvulus 0.0064 0.0907 0.1985
Loa Loa (eye worm) AUR protein kinase 0.0074 0.1095 0.1095
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0053
Plasmodium falciparum protein kinase 5 0.0058 0.0796 0.1423
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0187 0.3202 0.3202
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0079 0.1186 1
Echinococcus granulosus cyclin dependent kinase 0.0058 0.0796 0.2194
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0073
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0074 0.1095 0.3015
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0025 0.0187 0.0516
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.021 0.3631 1
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0054 0.0732 0.4949
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0019 0.0073 0.0055
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0732 0.2016
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0036 0.0401 0.1104
Trichomonas vaginalis CMGC family protein kinase 0.0064 0.0907 0.7491
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0226 0.3939 0.3939
Echinococcus granulosus hypothetical protein 0.0072 0.1072 0.2952
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0058 0.0796 0.1423
Echinococcus granulosus homeodomain interacting protein kinase 3 0.021 0.3631 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0054 0.0732 0.4949
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0074 0.1095 0.2871
Trichomonas vaginalis AGC family protein kinase 0.0074 0.1095 0.9181
Schistosoma mansoni hypothetical protein 0.0019 0.0073 0.0202
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0079 0.1186 1
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0079 0.1186 0.1186
Loa Loa (eye worm) hypothetical protein 0.0054 0.0732 0.0732
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0287
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.003 0.0287 0.079
Trichomonas vaginalis AGC family protein kinase 0.0074 0.1095 0.9181
Entamoeba histolytica protein kinase domain containing protein 0.0064 0.0907 0.2343
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0796 0.6499
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0019 0.0073 0.0202
Echinococcus granulosus protein kinase shaggy 0.0064 0.0907 0.2498
Loa Loa (eye worm) CDC7 protein kinase 0.0074 0.1107 0.1107
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.003 0.0287 0.0652
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0198 0.341 0.9393
Trypanosoma cruzi cdc2-related kinase 3 0.0058 0.0796 0.5668
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0036 0.0401 0.1104
Giardia lamblia Kinase, CMGC CLK 0.0079 0.1186 1
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0025 0.0187 0.0516
Echinococcus multilocularis 0.0078 0.118 0.315
Brugia malayi hypothetical protein 0.003 0.0287 0.0215
Entamoeba histolytica protein kinase domain containing protein 0.021 0.3631 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0064 0.0907 0.2498
Giardia lamblia Aurora kinase 0.0074 0.1095 0.9087
Onchocerca volvulus 0.0167 0.2826 0.813
Echinococcus granulosus cyclin dependent kinase 1 0.0058 0.0796 0.2194
Schistosoma mansoni hypothetical protein 0.003 0.0287 0.079
Entamoeba histolytica protein kinase, putative 0.0025 0.0187 0.0321
Trypanosoma cruzi aurora B kinase, putative 0.0074 0.1095 0.8986

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) > 5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PIM1 ChEMBL. No reference
Ki (functional) = 5.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: IRAK4 ChEMBL. No reference
Ki (functional) = 5.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: HIPK2 ChEMBL. No reference
Ki (functional) = 6 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MKNK2 ChEMBL. No reference
Ki (functional) = 6.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP4K4 ChEMBL. No reference
Ki (functional) = 6.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKACA ChEMBL. No reference
Ki (functional) = 6.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK2 ChEMBL. No reference
Ki (functional) = 6.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: GSK3B ChEMBL. No reference
Ki (functional) = 7.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDC7 ChEMBL. No reference
Ki (functional) = 7.6 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ROCK2 ChEMBL. No reference
Ki (functional) = 8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CLK4 ChEMBL. No reference
Ki (binding) = 0.016 uM Inhibition of JAK2 after 1 hr using biotinylated PDKtide as substrate ChEMBL. 21282054
Ki (binding) = 0.016 uM Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate ChEMBL. 21282054
Ki (binding) = 0.026 uM Inhibition of Aurora kinase 2 after 1 hr using biotinylated kemptide as substrate ChEMBL. 21282054
Ki (binding) = 0.45 uM Inhibition of GSK3-beta after 1 hr ChEMBL. 21282054
Ki (binding) = 3.291 uM Inhibition of KDR after 1 hr ChEMBL. 21282054
Ki (binding) = 3.588 uM Inhibition of Pak4 after 1 hr using biotinylated L15 peptide as substrate ChEMBL. 21282054
Ki (binding) = 5.155 uM Inhibition of Pim1 after 1 hr using biotinylated AL1peptide as substrate ChEMBL. 21282054

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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