Detailed information for compound 1509702

Basic information

Technical information
  • TDR Targets ID: 1509702
  • Name: N'-(8-chloroisoquinolin-1-yl)-N,N-diethylpent ane-1,4-diamine
  • MW: 319.872 | Formula: C18H26ClN3
  • H donors: 1 H acceptors: 1 LogP: 4.97 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCCC(Nc1nccc2c1c(Cl)ccc2)C)CC
  • InChi: 1S/C18H26ClN3/c1-4-22(5-2)13-7-8-14(3)21-18-17-15(11-12-20-18)9-6-10-16(17)19/h6,9-12,14H,4-5,7-8,13H2,1-3H3,(H,20,21)
  • InChiKey: CNPYOSIWMDNAMU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(8-chloro-1-isoquinolyl)-N,N-diethyl-pentane-1,4-diamine
  • N'-(8-chloro-1-isoquinolyl)-N,N-diethylpentane-1,4-diamine
  • 4-[(8-chloro-1-isoquinolyl)amino]pentyl-diethyl-amine
  • N'-(8-chloroisoquinolin-1-yl)-N,N-diethyl-pentane-1,4-diamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cytohesin 3 0.0023 0.0049 0.0049
Schistosoma mansoni regulator of G protein signaling 0.0252 0.1536 0.1536
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0023 0.0049 0.0058
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0023 0.0049 0.0058
Echinococcus granulosus oxysterol binding protein 9 0.0023 0.0049 0.0058
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0055 0.0055
Echinococcus granulosus Oxysterol binding protein 11 0.0023 0.0049 0.0058
Entamoeba histolytica PH domain containing protein kinase, putative 0.003 0.0091 0.0285
Entamoeba histolytica PH domain containing protein kinase, putative 0.003 0.0091 0.0285
Brugia malayi Plekhf2 protein 0.0023 0.0049 0.0049
Loa Loa (eye worm) Plekhf2 protein 0.0023 0.0049 0.0049
Echinococcus granulosus Pleckstrin y 0.0023 0.0049 0.0058
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.003 0.0091 0.164
Brugia malayi serine/threonine-protein kinase 6 0.0063 0.0307 0.0307
Echinococcus multilocularis regulator of G protein signaling 3 0.0252 0.1536 0.1837
Loa Loa (eye worm) AUR protein kinase 0.0063 0.0307 0.0307
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0023 0.0049 0.0049
Brugia malayi PXA domain containing protein 0.0252 0.1536 0.1536
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0252 0.1536 1
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0121 0.0486
Toxoplasma gondii protein kinase domain-containing protein 0.003 0.0091 0.164
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0023 0.0049 0.0058
Echinococcus multilocularis regulator of G protein signaling 7 0.0252 0.1536 0.1837
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0026 0.007 0.0144
Schistosoma mansoni vav2 0.0023 0.0049 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.1536 1
Echinococcus multilocularis actin binding protein anillin 0.0023 0.0049 0.0058
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0307 0.1739
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0023 0.0049 0.0049
Echinococcus granulosus myotubularin protein 13 0.0023 0.0049 0.0058
Loa Loa (eye worm) hypothetical protein 0.006 0.029 0.029
Echinococcus granulosus axis inhibition protein axin 0.0252 0.1536 0.1837
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Trypanosoma cruzi NIMA-related kinase, putative 0.003 0.0091 0.164
Brugia malayi regulator of G-protein signaling rgs-7 0.0252 0.1536 0.1536
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Brugia malayi Cadps2 protein 0.0023 0.0049 0.0049
Schistosoma mansoni serine/threonine protein kinase 0.1191 0.7642 0.7642
Echinococcus granulosus DCC interacting protein 13 beta 0.0023 0.0049 0.0058
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0026 0.007 0.0144
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1302 0.8362 1
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Schistosoma mansoni hypothetical protein 0.0023 0.0049 0.0049
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0137 0.0163
Echinococcus granulosus pdz domain containing protein 0.0023 0.0049 0.0058
Schistosoma mansoni serine/threonine protein kinase 0.1191 0.7642 0.7642
Echinococcus multilocularis semaphorin 5B 0.006 0.029 0.0347
Brugia malayi serine/threonine protein kinase 6 0.0063 0.0307 0.0307
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Schistosoma mansoni growth factor receptor-bound protein 0.0023 0.0049 0.0049
Entamoeba histolytica PH domain containing protein kinase, putative 0.003 0.0091 0.0285
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Echinococcus multilocularis Rho GTPase activating protein 24 0.0023 0.0049 0.0058
Echinococcus multilocularis Regulator of G protein signaling 20 0.0252 0.1536 0.1837
Echinococcus granulosus cytohesin 1 0.0023 0.0049 0.0058
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Echinococcus multilocularis myotubularin protein 13 0.0023 0.0049 0.0058
Trypanosoma cruzi Protein kinase B 0.003 0.0091 0.164
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.007 0.0144
Entamoeba histolytica p21-activated kinase 0.003 0.0091 0.0285
Entamoeba histolytica hypothetical protein 0.0252 0.1536 1
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0023 0.0049 0.0058
Echinococcus multilocularis axis inhibition protein axin 0.0252 0.1536 0.1837
Echinococcus multilocularis calcium dependent secretion activator 1 0.0023 0.0049 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.1536 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0252 0.1536 0.1536
Entamoeba histolytica hypothetical protein 0.003 0.0091 0.0285
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0023 0.0049 0.0049
Schistosoma mansoni axis inhibition protein axin 0.0252 0.1536 0.1536
Entamoeba histolytica protein kinase domain containing protein 0.0035 0.0125 0.0515
Trypanosoma cruzi serine/threonine protein kinase, putative 0.003 0.0091 0.164
Echinococcus granulosus expressed protein 0.0252 0.1536 0.1837
Brugia malayi PH domain containing protein 0.0023 0.0049 0.0049
Brugia malayi IPT/TIG domain containing protein 0.0026 0.007 0.007
Loa Loa (eye worm) plexin A 0.0158 0.0926 0.0926
Brugia malayi Variant SH3 domain containing protein 0.0023 0.0049 0.0049
Schistosoma mansoni axis inhibition protein axin 0.0252 0.1536 0.1536
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0023 0.0049 0.0049
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.003 0.0091 0.0285
Entamoeba histolytica hypothetical protein 0.0026 0.007 0.0144
Entamoeba histolytica protein kinase, putative 0.003 0.0091 0.0285
Loa Loa (eye worm) RGS-3 protein 0.0252 0.1536 0.1536
Loa Loa (eye worm) hypothetical protein 0.0071 0.0362 0.0362
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Entamoeba histolytica hypothetical protein 0.003 0.0091 0.0285
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0023 0.0049 0.0058
Echinococcus multilocularis pleckstrin y domain containing family A 0.0023 0.0049 0.0058
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.003 0.0091 0.164
Brugia malayi Probable exocyst complex component Sec5 0.0026 0.007 0.007
Loa Loa (eye worm) AUR protein kinase 0.0063 0.0307 0.0307
Schistosoma mansoni plexin 0.0071 0.0362 0.0362
Trypanosoma brucei rac serine-threonine kinase, putative 0.003 0.0091 0.164
Entamoeba histolytica hypothetical protein 0.0026 0.007 0.0144
Echinococcus granulosus Pleckstrin y 0.0023 0.0049 0.0058
Brugia malayi Oxysterol binding protein 0.0023 0.0049 0.0049
Schistosoma mansoni semaphorin 5-related 0.006 0.029 0.029
Echinococcus multilocularis Oxysterol binding protein 11 0.0023 0.0049 0.0058
Loa Loa (eye worm) hypothetical protein 0.006 0.029 0.029
Brugia malayi MAX-1A 0.0023 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0026 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0023 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0026 0.007 0.007
Brugia malayi PH domain containing protein 0.0023 0.0049 0.0049
Leishmania major protein kinase, putative 0.003 0.0091 0.164
Echinococcus multilocularis Pleckstrin y 0.0023 0.0049 0.0058
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.003 0.0091 0.164
Schistosoma mansoni protein kinase 0.0063 0.0307 0.0307
Entamoeba histolytica hypothetical protein 0.0026 0.007 0.0144
Schistosoma mansoni z-protein (S1r protein) 0.0252 0.1536 0.1536
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0023 0.0049 0.0049
Echinococcus multilocularis Pleckstrin y 0.0023 0.0049 0.0058
Entamoeba histolytica hypothetical protein 0.0026 0.007 0.0144
Echinococcus multilocularis hypothetical protein 0.006 0.029 0.0347
Brugia malayi Dynamin 0.0023 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0023 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Schistosoma mansoni hypothetical protein 0.006 0.029 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.007 0.0144
Echinococcus multilocularis DCC interacting protein 13 beta 0.0023 0.0049 0.0058
Brugia malayi hypothetical protein 0.0023 0.0049 0.0049
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0252 0.1536 0.1536
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0307 0.0307
Echinococcus granulosus aurora kinase A 0.0063 0.0307 0.0367
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0023 0.0049 0.0058
Brugia malayi hypothetical protein 0.0252 0.1536 0.1536
Loa Loa (eye worm) hypothetical protein 0.006 0.029 0.029
Loa Loa (eye worm) AUR protein kinase 0.0063 0.0307 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.007 0.0144
Loa Loa (eye worm) hypothetical protein 0.006 0.029 0.029
Echinococcus multilocularis oxysterol binding protein 1 0.0023 0.0049 0.0058
Brugia malayi plexin A 0.0158 0.0926 0.0926
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0307 0.1739
Echinococcus multilocularis regulator of G protein signaling 3 0.0252 0.1536 0.1837
Brugia malayi Plexin repeat family protein 0.0132 0.0754 0.0754
Loa Loa (eye worm) hypothetical protein 0.0132 0.0754 0.0754
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0023 0.0049 0.0058
Echinococcus multilocularis cytohesin 1 0.0023 0.0049 0.0058
Loa Loa (eye worm) hypothetical protein 0.006 0.029 0.029
Brugia malayi regulator of G-protein signaling egl-10 0.0252 0.1536 0.1536
Schistosoma mansoni regulator of G protein signaling 0.0252 0.1536 0.1536
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0023 0.0049 0.0058
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0939 0.6004 0.718
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.003 0.0091 0.0285
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.003 0.0091 0.164
Echinococcus multilocularis Ras associated and pleckstrin y 0.0023 0.0049 0.0058
Schistosoma mansoni regulator of G protein signaling 0.0252 0.1536 0.1536
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Entamoeba histolytica protein kinase, putative 0.0063 0.0307 0.1739
Echinococcus granulosus serine/threonine protein kinase 0.003 0.0091 0.0109
Brugia malayi PH domain containing protein 0.0023 0.0049 0.0049
Entamoeba histolytica protein kinase, putative 0.003 0.0091 0.0285
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Onchocerca volvulus 0.006 0.029 0.3426
Echinococcus granulosus axis inhibition protein axin 0.0252 0.1536 0.1837
Entamoeba histolytica protein kinase, putative 0.003 0.0091 0.0285
Leishmania major protein kinase, putative 0.0063 0.0307 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0252 0.1536 0.1536
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.003 0.0091 0.164
Schistosoma mansoni dynamin 0.0023 0.0049 0.0049
Echinococcus granulosus pleckstrin y domain containing family A 0.0023 0.0049 0.0058
Loa Loa (eye worm) rho-GTPase-activating 0.0023 0.0049 0.0049
Loa Loa (eye worm) PH domain-containing protein 0.0023 0.0049 0.0049
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0023 0.0049 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.1536 1
Brugia malayi PH domain containing protein 0.0023 0.0049 0.0049
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0121 0.0486
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Echinococcus granulosus oxysterol binding protein 3 0.0023 0.0049 0.0058
Echinococcus granulosus exocyst complex component 2 0.0026 0.007 0.0084
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Entamoeba histolytica protein kinase, putative 0.003 0.0091 0.0285
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0023 0.0049 0.0049
Brugia malayi Syntrophin-1 0.0023 0.0049 0.0049
Brugia malayi Sema domain containing protein 0.006 0.029 0.029
Brugia malayi PH domain containing protein 0.0023 0.0049 0.0049
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1302 0.8362 0.8362
Schistosoma mansoni hypothetical protein 0.0071 0.0362 0.0362
Loa Loa (eye worm) syntrophin-1 0.0023 0.0049 0.0049
Schistosoma mansoni regulator of G protein signaling 0.0252 0.1536 0.1536
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.003 0.0091 0.164
Leishmania major folate/biopterin transporter, putative 0.003 0.0091 0.164
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.007 0.0144
Echinococcus multilocularis GRB2 associated binding protein 3 0.0023 0.0049 0.0058
Echinococcus multilocularis dynamin 1 0.0023 0.0049 0.0058
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0252 0.1536 0.1536
Echinococcus multilocularis aurora kinase A 0.0063 0.0307 0.0367
Echinococcus multilocularis rac serine:threonine kinase 0.003 0.0091 0.0109
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Echinococcus multilocularis regulator of G protein signaling 7 0.0252 0.1536 0.1837
Echinococcus multilocularis beta adrenergic receptor kinase 0.1191 0.7642 0.9138
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0023 0.0049 0.0058
Brugia malayi Dynamin 0.0023 0.0049 0.0049
Brugia malayi PH domain containing protein 0.0023 0.0049 0.0049
Brugia malayi Protein kinase domain containing protein 0.003 0.0091 0.0091
Brugia malayi DNA-binding protein LAG-1 0.0026 0.007 0.007
Schistosoma mansoni rho gtpase activating protein 0.0023 0.0049 0.0049
Brugia malayi serine/threonine kinase 12 0.0063 0.0307 0.0307
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0023 0.0049 0.0049
Plasmodium falciparum calcium-dependent protein kinase 7 0.003 0.0091 0.164
Brugia malayi Sema domain containing protein 0.006 0.029 0.029
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Echinococcus granulosus GRB2 associated binding protein 3 0.0023 0.0049 0.0058
Loa Loa (eye worm) hypothetical protein 0.0026 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.007 0.0144
Schistosoma mansoni goodpasture antigen-binding protein 0.0023 0.0049 0.0049
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0137 0.0137
Entamoeba histolytica protein kinase, putative 0.003 0.0091 0.0285
Schistosoma mansoni syntrophin 0.0023 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0026 0.007 0.007
Brugia malayi TBC domain containing protein 0.0023 0.0049 0.0049
Schistosoma mansoni serine/threonine-protein kinase 0.003 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.007 0.0144
Brugia malayi Oxysterol-binding protein 0.0023 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.006 0.029 0.029
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0158 0.0158
Brugia malayi hypothetical protein 0.0252 0.1536 0.1536
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Entamoeba histolytica protein kinase , putative 0.0063 0.0307 0.1739
Schistosoma mansoni zinc finger protein 0.0023 0.0049 0.0049
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0252 0.1536 0.1536
Trypanosoma cruzi rac serine-threonine kinase, putative 0.003 0.0091 0.164
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1302 0.8362 0.8362
Entamoeba histolytica PH domain containing protein kinase, putative 0.003 0.0091 0.0285
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.003 0.0091 0.164
Schistosoma mansoni vesicular amine transporter 0.0018 0.0016 0.0016
Entamoeba histolytica hypothetical protein 0.0252 0.1536 1
Schistosoma mansoni hypothetical protein 0.006 0.029 0.029
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Brugia malayi hypothetical protein 0.006 0.029 0.029
Schistosoma mansoni plexin 0.0132 0.0754 0.0754
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Loa Loa (eye worm) cytohesin 3 0.0023 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0137 0.0163
Echinococcus multilocularis axis inhibition protein axin 0.0252 0.1536 0.1837
Toxoplasma gondii aurora kinase 0.0063 0.0307 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0252 0.1536 0.1837
Schistosoma mansoni zinc finger protein 0.0023 0.0049 0.0049
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Loa Loa (eye worm) sema domain-containing protein 0.006 0.029 0.029
Entamoeba histolytica protein kinase, putative 0.003 0.0091 0.0285
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0023 0.0049 0.0058
Leishmania major protein kinase, putative 0.003 0.0091 0.164
Loa Loa (eye worm) uncoordinated protein 104 0.0023 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0026 0.007 0.007
Brugia malayi Uncoordinated protein 104 0.0023 0.0049 0.0049
Brugia malayi Regulator of G protein signaling domain containing protein 0.0252 0.1536 0.1536
Trypanosoma cruzi NIMA-related kinase, putative 0.003 0.0091 0.164
Onchocerca volvulus 0.0132 0.0754 1
Schistosoma mansoni oxysterol-binding protein 1 0.0023 0.0049 0.0049
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.003 0.0091 0.164
Echinococcus granulosus twitchin 0.0022 0.0042 0.0051
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Giardia lamblia Aurora kinase 0.0063 0.0307 0.5
Trypanosoma brucei protein kinase, putative 0.003 0.0091 0.164
Trypanosoma brucei aurora B kinase 0.0063 0.0307 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.1191 0.7642 0.7642
Brugia malayi Regulator of G protein signaling domain containing protein 0.0252 0.1536 0.1536
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0063 0.0307 0.1739
Trypanosoma cruzi rac serine-threonine kinase, putative 0.003 0.0091 0.164
Echinococcus multilocularis Pleckstrin y 0.0023 0.0049 0.0058
Entamoeba histolytica protein kinase, putative 0.0063 0.0307 0.1739
Schistosoma mansoni centaurin alpha 0.0023 0.0049 0.0049
Echinococcus multilocularis exocyst complex component 2 0.0026 0.007 0.0084
Echinococcus granulosus transcription factor collier 0.0026 0.007 0.0084
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.003 0.0091 0.164
Entamoeba histolytica cell surface protease gp63, putative 0.0026 0.007 0.0144
Entamoeba histolytica PH domain containing protein kinase, putative 0.003 0.0091 0.0285
Echinococcus granulosus Regulator of G protein signaling 20 0.0252 0.1536 0.1837
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.1536 1
Schistosoma mansoni oxysterol-binding protein 1 0.0023 0.0049 0.0049
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.003 0.0091 0.164
Echinococcus granulosus regulator of G protein signaling 3 0.0252 0.1536 0.1837
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.1536 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0105 0.0105
Echinococcus multilocularis plexin a4 0.0158 0.0926 0.1107
Schistosoma mansoni fibrocystin l 0.0026 0.007 0.007
Leishmania major serine/threonine-protein kinase a, putative 0.003 0.0091 0.164
Brugia malayi hypothetical protein 0.006 0.029 0.029
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0026 0.007 0.0144
Schistosoma mansoni hypothetical protein 0.0026 0.007 0.007
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Echinococcus granulosus dynamin 1 0.0023 0.0049 0.0058
Loa Loa (eye worm) hypothetical protein 0.0252 0.1536 0.1536
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0023 0.0049 0.0058
Entamoeba histolytica protein kinase, putative 0.003 0.0091 0.0285
Brugia malayi PH domain containing protein 0.0023 0.0049 0.0049
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0063 0.0307 0.0367
Echinococcus granulosus semaphorin 1A 0.006 0.029 0.0347
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0252 0.1536 0.1536
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0024 0.0055 0.0055
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0307 0.1739
Entamoeba histolytica tyrosin kinase, putative 0.0035 0.0125 0.0515
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0023 0.0049 0.0058
Brugia malayi PXA domain containing protein 0.0252 0.1536 0.1536
Loa Loa (eye worm) hypothetical protein 0.0252 0.1536 0.1536
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.1536 1
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Schistosoma mansoni dynamin 0.0023 0.0049 0.0049
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0023 0.0049 0.0049
Echinococcus multilocularis expressed protein 0.0252 0.1536 0.1837
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0063 0.0307 1
Loa Loa (eye worm) sema domain-containing protein 0.006 0.029 0.029
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0026 0.007 0.0144
Echinococcus multilocularis regulator of G protein signaling 0.0252 0.1536 0.1837
Entamoeba histolytica PH domain containing protein kinase, putative 0.003 0.0091 0.0285
Echinococcus granulosus beta 1 syntrophin 0.0023 0.0049 0.0058
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.003 0.0091 0.164
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Echinococcus multilocularis beta 1 syntrophin 0.0023 0.0049 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.007 0.0144
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0307 0.1739
Echinococcus multilocularis oxysterol binding protein 3 0.0023 0.0049 0.0058
Echinococcus granulosus beta-adrenergic receptor kinase 0.1191 0.7642 0.9138
Echinococcus granulosus Rho GTPase activating protein 24 0.0023 0.0049 0.0058
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1302 0.8362 0.8362
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0252 0.1536 0.1536
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Schistosoma mansoni serine/threonine-protein kinase 0.003 0.0091 0.0091
Echinococcus granulosus plexin a4 0.0158 0.0926 0.1107
Brugia malayi PH domain containing protein 0.0023 0.0049 0.0049
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0252 0.1536 0.1536
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0026 0.007 0.0144
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0023 0.0049 0.0058
Schistosoma mansoni myotubularin-related protein 0.0023 0.0049 0.0049
Echinococcus granulosus calcium dependent secretion activator 1 0.0023 0.0049 0.0058
Echinococcus granulosus regulator of G protein signaling 3 0.0252 0.1536 0.1837
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0023 0.0049 0.0049
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0063 0.0307 0.1739
Loa Loa (eye worm) AGC/AKT protein kinase 0.003 0.0091 0.0091
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0023 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0023 0.0049 0.0049
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0023 0.0049 0.0058
Schistosoma mansoni regulator of G protein signaling 0.0252 0.1536 0.1536
Echinococcus granulosus Pleckstrin y 0.0023 0.0049 0.0058
Echinococcus granulosus G protein coupled receptor kinase 1 0.0939 0.6004 0.718
Echinococcus granulosus regulator of G protein signaling 7 0.0252 0.1536 0.1837
Loa Loa (eye worm) PXA domain-containing protein 0.0252 0.1536 0.1536
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.003 0.0091 0.164
Echinococcus granulosus semaphorin 5B 0.006 0.029 0.0347
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0063 0.0307 0.0367
Plasmodium falciparum serine/threonine protein kinase, putative 0.0063 0.0307 1
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.003 0.0091 0.164
Entamoeba histolytica protein kinase domain containing protein 0.0063 0.0307 0.1739
Loa Loa (eye worm) oxysterol binding protein 0.0023 0.0049 0.0049
Echinococcus granulosus regulator of G protein signaling 7 0.0252 0.1536 0.1837
Brugia malayi PH domain containing protein 0.0023 0.0049 0.0049
Schistosoma mansoni goodpasture antigen-binding protein 0.0023 0.0049 0.0049
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1302 0.8362 1
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Schistosoma mansoni hypothetical protein 0.0023 0.0049 0.0049
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0252 0.1536 0.1536
Echinococcus granulosus oxysterol binding protein 1 0.0023 0.0049 0.0058
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0023 0.0049 0.0049
Echinococcus multilocularis pdz domain containing protein 0.0023 0.0049 0.0058
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Echinococcus multilocularis transcription factor collier 0.0026 0.007 0.0084
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0252 0.1536 0.1837
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0049
Brugia malayi Pleckstrin Homology Domain 0.0023 0.0049 0.0049
Entamoeba histolytica hypothetical protein 0.0252 0.1536 1
Echinococcus multilocularis oxysterol binding protein 9 0.0023 0.0049 0.0058
Brugia malayi Variant SH3 domain containing protein 0.0023 0.0049 0.0049
Trypanosoma cruzi aurora B kinase, putative 0.0063 0.0307 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.003 0.0091 0.164
Brugia malayi probable spectrin beta chain 0.0023 0.0049 0.0049
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Trichomonas vaginalis AGC family protein kinase 0.003 0.0091 0.0285
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0023 0.0049 0.0058
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0063 0.0307 0.1739

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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