Detailed information for compound 1519504

Basic information

Technical information
  • TDR Targets ID: 1519504
  • Name: 2-(4-methoxyphenyl)-N-(2-morpholin-4-ylethyl) -6-propan-2-ylquinoline-4-carboxamide
  • MW: 433.543 | Formula: C26H31N3O3
  • H donors: 1 H acceptors: 2 LogP: 3.89 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1nc2ccc(cc2c(c1)C(=O)NCCN1CCOCC1)C(C)C
  • InChi: 1S/C26H31N3O3/c1-18(2)20-6-9-24-22(16-20)23(26(30)27-10-11-29-12-14-32-15-13-29)17-25(28-24)19-4-7-21(31-3)8-5-19/h4-9,16-18H,10-15H2,1-3H3,(H,27,30)
  • InChiKey: JBEBDPBZOJBQPV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-isopropyl-2-(4-methoxyphenyl)-N-(2-morpholinoethyl)quinoline-4-carboxamide
  • 6-isopropyl-2-(4-methoxyphenyl)-N-(2-morpholinoethyl)-4-quinolinecarboxamide
  • 6-isopropyl-2-(4-methoxyphenyl)-N-(2-morpholinoethyl)cinchoninamide
  • 2-(4-methoxyphenyl)-N-(2-morpholin-4-ylethyl)-6-propan-2-yl-quinoline-4-carboxamide
  • EU-0030651

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0074 0.0635
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0012 0.0074 0.0672
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.016 0.2249 1
Schistosoma mansoni ferritin light chain 0.0008 0.0022 0.0022
Onchocerca volvulus 0.005 0.0635 0.2823
Loa Loa (eye worm) glutathione reductase 0.0046 0.0578 0.1322
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0051 0.0657 0.0657
Mycobacterium tuberculosis Conserved protein 0.0304 0.4374 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1312 0.3
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0135 0.1221
Onchocerca volvulus 0.0008 0.0024 0.0109
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0135 0.0817
Onchocerca volvulus 0.0029 0.032 0.1425
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0285 0.0651
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0048 0.0048
Brugia malayi EGF-like domain containing protein 0.0008 0.0024 0.0074
Schistosoma mansoni sphingosine kinase A B 0.0304 0.4374 0.4374
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.024 0.0549
Echinococcus multilocularis fibropellin Ia 0.0008 0.0024 0.0024
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0026 0.0285 0.0651
Loa Loa (eye worm) CAMK/PIM protein kinase 0.016 0.2249 0.5141
Plasmodium falciparum thioredoxin reductase 0.0016 0.0135 0.0817
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.0022 0.005
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0154 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.024 0.0549
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.024 0.0549
Loa Loa (eye worm) histone methyltransferase 0.0009 0.003 0.0069
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0792 0.0792
Onchocerca volvulus 0.0008 0.0024 0.0109
Schistosoma mansoni loxhd1 0.0119 0.1655 0.1655
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.005 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.011
Loa Loa (eye worm) ceramide kinase 0.0012 0.0074 0.017
Schistosoma mansoni hypothetical protein 0.0008 0.0024 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0135 0.1221
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.011
Trypanosoma brucei diacylglycerol kinase, putative 0.0012 0.0074 0.0672
Echinococcus granulosus neurogenic locus protein delta 0.0008 0.0024 0.0024
Schistosoma mansoni peroxidasin 0.0026 0.0285 0.0285
Brugia malayi diacylglycerol kinase 0.0012 0.0074 0.0224
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0048 0.0048
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0074 0.0635
Echinococcus granulosus neural cadherin 0.0008 0.0024 0.0024
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0048 0.0048
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0048 0.011
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0154 0.0353
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.005 0.0635 0.5733
Brugia malayi notch-like transmembrane receptor 0.0008 0.0024 0.0074
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0657 0.0657
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0074 0.017
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0135 0.0407
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.5887 0.5887
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0051 0.0657 0.0657
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0048 0.0048
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.024 0.0549
Echinococcus granulosus Diacylglycerol kinase zeta 0.0012 0.0074 0.0074
Echinococcus multilocularis cpg binding protein 0.003 0.0344 0.0344
Loa Loa (eye worm) doublecortin family protein 0.0119 0.1655 0.3784
Echinococcus multilocularis protein dispatched 1 0.0047 0.0592 0.0592
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0036 0.0426 0.1282
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0048 0.011
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0087 0.1173 0.5215
Echinococcus multilocularis ferritin 0.0008 0.0022 0.0022
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0539 0.0539
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0048 0.0048
Echinococcus multilocularis Diacylglycerol kinase theta 0.0012 0.0074 0.0074
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0285 0.1267
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0087 0.1173 0.1173
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0285 0.1267
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0012 0.0074 0.0074
Mycobacterium ulcerans ATPase 0.0052 0.0662 0.1513
Schistosoma mansoni protein kinase 0.0051 0.0657 0.0657
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Echinococcus multilocularis fat cadherin tumor suppressor 0.0008 0.0024 0.0024
Schistosoma mansoni thyroid hormone receptor 0.001 0.0048 0.0048
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0048 0.0048
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0135 0.0135
Brugia malayi EGF-like domain containing protein 0.0008 0.0024 0.0074
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Echinococcus granulosus Polycystic kidney disease protein 0.0119 0.1655 0.1655
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0048 0.0048
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0024 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.014 0.0321
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.017
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0048 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0048 0.0145
Onchocerca volvulus 0.0119 0.1655 0.7361
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.3325 0.7602
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0135 0.1221
Echinococcus granulosus protein jagged 2 0.0008 0.0024 0.0024
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0082 0.1107 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0539 0.0539
Brugia malayi CXXC zinc finger family protein 0.0029 0.032 0.0964
Echinococcus granulosus sphingosine kinase 1 0.0304 0.4374 0.4374
Onchocerca volvulus 0.0026 0.0285 0.1267
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0135 0.0309
Loa Loa (eye worm) hypothetical protein 0.0017 0.0154 0.0353
Toxoplasma gondii cell division protein CDC48CY 0.0087 0.1173 1
Schistosoma mansoni notch 0.0008 0.0024 0.0024
Onchocerca volvulus 0.001 0.0048 0.0214
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.016 0.2249 0.2249
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0285 0.1267
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0048 0.0145
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0285 0.0857
Mycobacterium tuberculosis Putative conserved ATPase 0.0052 0.0662 0.1513
Echinococcus granulosus protein kinase 0.012 0.1672 0.1672
Echinococcus multilocularis protein jagged 1 0.0008 0.0024 0.0024
Brugia malayi valosin containing protein 0.0051 0.0646 0.1944
Echinococcus multilocularis protein jagged 1 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0135 0.0135
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0578 0.3494
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0506 0.1157
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0005 0.0005
Toxoplasma gondii thioredoxin reductase 0.0046 0.0578 0.4931
Loa Loa (eye worm) hypothetical protein 0.0026 0.0285 0.0651
Plasmodium vivax multidomain scavenger receptor, putative 0.0119 0.1655 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.024 0.0549
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0048 0.0145
Trichomonas vaginalis ferritin, putative 0.0008 0.0022 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.016 0.2249 0.2249
Loa Loa (eye worm) hypothetical protein 0.0026 0.0285 0.0651
Trypanosoma cruzi Sphingosine kinase 0.0012 0.0074 0.0672
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0074 0.0635
Onchocerca volvulus Slit protein homolog 0.0008 0.0024 0.0109
Echinococcus granulosus MAP kinase activated protein kinase 2 0.018 0.2552 0.2552
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0135 0.0309
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.011
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0506 0.0506
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0074 0.0635
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Entamoeba histolytica hypothetical protein 0.0043 0.0539 0.1233
Schistosoma mansoni lipoxygenase 0.0651 0.948 0.948
Brugia malayi hypothetical protein 0.0043 0.0539 0.1622
Plasmodium vivax cell division cycle ATPase, putative 0.0031 0.0361 0.218
Entamoeba histolytica hypothetical protein, conserved 0.0304 0.4374 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.024 0.0549
Leishmania major trypanothione reductase 0.0046 0.0578 0.5223
Loa Loa (eye worm) hypothetical protein 0.0026 0.0285 0.0651
Brugia malayi AMP-binding enzyme family protein 0.0023 0.024 0.0722
Echinococcus multilocularis lipoxygenase domain containing protein 0.0119 0.1655 0.1655
Echinococcus granulosus cpg binding protein 0.003 0.0344 0.0344
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0154 0.0353
Echinococcus multilocularis notch 0.0008 0.0024 0.0024
Treponema pallidum NADH oxidase 0.0016 0.0135 1
Echinococcus granulosus notch 0.0008 0.0024 0.0024
Brugia malayi glutathione reductase 0.0046 0.0578 0.1739
Echinococcus granulosus RUN 0.0119 0.1655 0.1655
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0022 0.005
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0074 0.017
Brugia malayi EGF-like domain containing protein 0.0008 0.0024 0.0074
Echinococcus granulosus protein jagged 1 0.0008 0.0024 0.0024
Mycobacterium tuberculosis Probable reductase 0.0105 0.1447 0.3308
Schistosoma mansoni lipoxygenase 0.0437 0.6321 0.6321
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0012 0.0074 0.0635
Echinococcus multilocularis neurogenic locus notch protein 4 0.0008 0.0024 0.0024
Onchocerca volvulus 0.0008 0.0024 0.0109
Schistosoma mansoni hypothetical protein 0.0012 0.0074 0.0074
Brugia malayi Diacylglycerol kinase protein 2 0.0012 0.0074 0.0224
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1312 0.3946
Brugia malayi Blistered cuticle protein 3 0.0026 0.0285 0.0857
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0135 0.1737
Loa Loa (eye worm) hypothetical protein 0.0041 0.0506 0.1157
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.162 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0048 0.0145
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1447 0.3308
Schistosoma mansoni slit 0.0008 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0008 0.0024 0.0024
Trypanosoma brucei Sphingosine kinase 0.0012 0.0074 0.0672
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.011
Leishmania major diacylglycerol kinase, putative 0.0012 0.0074 0.0672
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0012 0.0074 0.0635
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0082 0.1107 0.1107
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0012 0.0074 0.0672
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0074 0.0672
Echinococcus granulosus ferritin 0.0008 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.0549
Onchocerca volvulus 0.0008 0.0024 0.0109
Schistosoma mansoni patched 1 0.0041 0.0506 0.0506
Schistosoma mansoni hypothetical protein 0.004 0.0484 0.0484
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.0022 0.005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0154 0.0353
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.024 0.0549
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1447 0.3308
Schistosoma mansoni laminin gamma-3 chain 0.0008 0.0024 0.0024
Brugia malayi Peroxidasin 0.0026 0.0285 0.0857
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0012 0.0074 0.0672
Echinococcus multilocularis RUN 0.0119 0.1655 0.1655
Brugia malayi diacylglycerol kinase 0.0012 0.0074 0.0224
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0135 0.1153
Brugia malayi Muscle positioning protein 4 0.0008 0.0024 0.0074
Echinococcus multilocularis microtubule associated protein 2 0.0687 1 1
Schistosoma mansoni vam6/vps39 related 0.005 0.0635 0.0635
Loa Loa (eye worm) VCP protein 0.0036 0.0426 0.0975
Schistosoma mansoni peroxidasin 0.0026 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0074 0.0672
Schistosoma mansoni hypothetical protein 0.0008 0.0024 0.0024
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0008 0.0024 0.0024
Brugia malayi Ceramide kinase 0.0012 0.0074 0.0224
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0154 0.0932
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Entamoeba histolytica hypothetical protein 0.0043 0.0539 0.1233
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.0549
Onchocerca volvulus Peroxidase homolog 0.0026 0.0285 0.1267
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0051 0.0657 0.0657
Schistosoma mansoni coup transcription factor 0.001 0.0048 0.0048
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0048 0.0048
Toxoplasma gondii diacylglycerol kinase, putative 0.0012 0.0074 0.0635
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.005 0.0635 0.0635
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1447 0.3308
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0135 0.1221
Schistosoma mansoni protein kinase 0.012 0.1672 0.1672
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0048 0.011
Loa Loa (eye worm) hypothetical protein 0.0051 0.0646 0.1478
Trypanosoma cruzi Valosin-containing protein, putative 0.0082 0.1107 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.024 0.0549
Trypanosoma cruzi Sphingosine kinase 0.0012 0.0074 0.0672
Schistosoma mansoni protein kinase 0.017 0.2406 0.2406
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0073 0.0219
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.011
Brugia malayi AMP-binding enzyme family protein 0.0023 0.024 0.0722
Loa Loa (eye worm) hypothetical protein 0.005 0.0635 0.1451
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0029 0.0086
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0051 0.0657 0.0657
Echinococcus granulosus expressed conserved protein 0.009 0.1226 0.1226
Plasmodium falciparum glutathione reductase 0.0046 0.0578 0.3494
Schistosoma mansoni hypothetical protein 0.0008 0.0024 0.0024
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0074 0.017
Brugia malayi AMP-binding enzyme family protein 0.0023 0.024 0.0722
Echinococcus granulosus FTZ F1 alpha 0.001 0.0048 0.0048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0048 0.0145
Plasmodium falciparum diacylglycerol kinase, putative 0.0012 0.0074 0.045
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.0022 0.0134
Onchocerca volvulus 0.0026 0.0285 0.1267
Echinococcus granulosus peroxidasin 0.0026 0.0285 0.0285
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0024 0.0024
Schistosoma mansoni ferritin 0.0008 0.0022 0.0022
Schistosoma mansoni notch 0.0008 0.0024 0.0024
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.004 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Plasmodium vivax glutathione reductase, putative 0.0046 0.0578 0.3494
Brugia malayi probable protein kinase 0.017 0.2406 0.7238
Brugia malayi hypothetical protein 0.0026 0.0285 0.0857
Schistosoma mansoni ferritin 0.0008 0.0022 0.0022
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0154 0.0353
Mycobacterium tuberculosis Diacylglycerol kinase 0.0012 0.0074 0.017
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0005 0.0005
Loa Loa (eye worm) Notch2 0.0008 0.0024 0.0056
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0087 0.1173 0.1173
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0012 0.0074 0.0074
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0578 0.5223
Loa Loa (eye worm) hypothetical protein 0.0026 0.0285 0.0651
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0048 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0048 0.0145
Brugia malayi Temporarily assigned gene name protein 59 0.005 0.0635 0.1909
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0087 0.1173 0.1173
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1447 0.3308
Brugia malayi nuclear receptor NHR-88 0.001 0.0048 0.0145
Brugia malayi Eye-specific diacylglycerol kinase 0.0012 0.0074 0.0224
Schistosoma mansoni hypothetical protein 0.0008 0.0024 0.0024
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0696 0.5939
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.003 0.003
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0285 0.0857
Brugia malayi hypothetical protein 0.0119 0.1655 0.4978
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0135 0.1221
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0012 0.0074 0.0074
Schistosoma mansoni notch 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.005 0.0635 0.1451
Onchocerca volvulus Putative cubilin 0.0008 0.0024 0.0109
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0135 0.0817
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0048 0.0048
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0074 0.0074
Schistosoma mansoni notch 0.0008 0.0024 0.0024
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0074 0.0635
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0026 0.0285 0.0651
Echinococcus granulosus delta-like protein 1 0.0008 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0048 0.0145
Schistosoma mansoni ferritin light chain 0.0008 0.0022 0.0022
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0008 0.0024 0.0109
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.005 0.0635 0.5733
Brugia malayi vesicle-fusing ATPase 0.0051 0.0646 0.1944
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0048 0.0145
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.024 0.0549
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0285 0.0651
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0285 0.0857
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.024 0.2169
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0285 0.0651
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0285 0.0857
Schistosoma mansoni hypothetical protein 0.004 0.0484 0.0484
Brugia malayi Cadherin domain containing protein 0.0008 0.0024 0.0074
Trypanosoma cruzi diacylglycerol kinase, putative 0.0012 0.0074 0.0672
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0005 0.0005
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0036 0.0426 0.0426
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0651 0.948 0.948
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0082 0.1107 0.6689
Brugia malayi GCC2 and GCC3 family protein 0.0008 0.0024 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0135 0.1221
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.005 0.0635 0.0635
Leishmania major sphingosine kinase A, B, putative 0.0012 0.0074 0.0672
Loa Loa (eye worm) hypothetical protein 0.0026 0.0285 0.0651
Loa Loa (eye worm) vesicle-fusing ATPase 0.0051 0.0646 0.1478
Loa Loa (eye worm) hypothetical protein 0.0026 0.0285 0.0651
Onchocerca volvulus 0.0008 0.0024 0.0109
Schistosoma mansoni notch 0.0008 0.0024 0.0024
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0074 0.017
Loa Loa (eye worm) hypothetical protein 0.0304 0.4374 1
Brugia malayi steroid hormone receptor 0.001 0.0048 0.0145
Schistosoma mansoni notch 0.0008 0.0024 0.0024
Plasmodium vivax diacylglycerol kinase, putative 0.0012 0.0074 0.045
Loa Loa (eye worm) hypothetical protein 0.0169 0.2384 0.5451
Trypanosoma brucei Valosin-containing protein 0.0082 0.1107 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.014 0.0321
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0578 0.1322
Schistosoma mansoni hypothetical protein 0.0043 0.0539 0.0539
Schistosoma mansoni hypothetical protein 0.0008 0.0024 0.0024
Schistosoma mansoni apoferritin-2 0.0008 0.0022 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.024 0.0549
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0048 0.0145
Loa Loa (eye worm) hypothetical protein 0.0012 0.0074 0.017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0048 0.011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0285 0.0651
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.012 0.1672 0.3823
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0012 0.0074 0.0672
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0135 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0023 0.024 0.0549
Loa Loa (eye worm) hypothetical protein 0.0017 0.0154 0.0353
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0506 0.0506
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0135 0.1221
Schistosoma mansoni cell polarity protein 0.0008 0.0024 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.014 0.0321
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1334 0.1334
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0048 0.0048
Schistosoma mansoni nuclear hormone receptor 0.001 0.0048 0.0048
Loa Loa (eye worm) diacylglycerol kinase 2 0.0012 0.0074 0.017
Onchocerca volvulus Ceramide kinase 1 homolog 0.0012 0.0074 0.0331
Trichomonas vaginalis bmru protein, putative 0.0012 0.0074 0.0635
Schistosoma mansoni apoferritin-2 0.0008 0.0022 0.0022
Mycobacterium ulcerans hypothetical protein 0.0304 0.4374 1
Echinococcus multilocularis peroxidasin 0.0026 0.0285 0.0285
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0082 0.1107 0.6689
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0135 0.0817
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.005 0.0635 0.5733
Schistosoma mansoni ferritin 0.0008 0.0022 0.0022
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0048 0.0048
Plasmodium falciparum diacylglycerol kinase, putative 0.0012 0.0074 0.045
Schistosoma mansoni rab6-interacting 0.0119 0.1655 0.1655
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0022 0.005
Echinococcus multilocularis expressed conserved protein 0.009 0.1226 0.1226
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.024 0.0549
Onchocerca volvulus 0.0119 0.1655 0.7361
Echinococcus multilocularis Polycystic kidney disease protein 0.0119 0.1655 0.1655
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1918 0.1918
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0135 0.0309
Loa Loa (eye worm) hypothetical protein 0.0026 0.0285 0.0651
Entamoeba histolytica cdc48-like protein, putative 0.0082 0.1107 0.2531
Leishmania major hypothetical protein, conserved 0.0012 0.0074 0.0672
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0048 0.0048
Schistosoma mansoni ferritin 0.0008 0.0022 0.0022
Echinococcus granulosus dnaJ subfamily B 0.0407 0.5887 0.5887
Echinococcus granulosus fibropellin Ia 0.0008 0.0024 0.0024
Plasmodium falciparum glutathione reductase 0.0016 0.0135 0.0817
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0048 0.0145
Echinococcus multilocularis protein jagged 2 0.0008 0.0024 0.0024
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0135 0.1221
Schistosoma mansoni thyroid hormone receptor 0.001 0.0048 0.0048
Plasmodium vivax diacylglycerol kinase, putative 0.0012 0.0074 0.045
Brugia malayi EGF-like domain containing protein 0.0008 0.0024 0.0074
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.016 0.2249 0.2249
Loa Loa (eye worm) hypothetical protein 0.0017 0.0154 0.0353
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0506 0.0506
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0651 0.948 0.948
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0024 0.0024
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0012 0.0074 0.0074
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0135 0.1221
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.024 0.0549
Echinococcus multilocularis expressed protein 0.0008 0.0022 0.0022
Schistosoma mansoni cpg binding protein 0.0029 0.032 0.032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0048 0.011
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0048 0.0048
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0052 0.0662 0.5643
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0012 0.0074 0.0074
Brugia malayi Protein kinase domain containing protein 0.016 0.2249 0.6763
Echinococcus granulosus Diacylglycerol kinase theta 0.0012 0.0074 0.0074
Echinococcus granulosus protein jagged 1 0.0008 0.0024 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0135 0.1221
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0135 0.1221
Trypanosoma cruzi diacylglycerol kinase, putative 0.0012 0.0074 0.0672
Echinococcus multilocularis lipoxygenase domain containing protein 0.0119 0.1655 0.1655
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0285 0.0857
Schistosoma mansoni hypothetical protein 0.004 0.0484 0.0484
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0073 0.0219
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0024 0.0024
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0135 0.1153
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.018 0.2552 0.5834
Onchocerca volvulus Peroxidase homolog 0.0026 0.0285 0.1267
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0024 0.0024
Echinococcus multilocularis neural cadherin 0.0008 0.0024 0.0024
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0048 0.0214
Schistosoma mansoni serine/threonine protein kinase 0.018 0.2552 0.2552
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0048 0.011
Brugia malayi Delta serrate ligand family protein 0.0008 0.0024 0.0074
Brugia malayi EGF-like domain containing protein 0.0008 0.0024 0.0074
Brugia malayi ecdysteroid receptor 0.001 0.0048 0.0145
Brugia malayi nuclear hormone receptor 0.001 0.0048 0.0145
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0051 0.0657 0.0657
Loa Loa (eye worm) hypothetical protein 0.0026 0.0285 0.0651
Trichomonas vaginalis bmru protein, putative 0.0012 0.0074 0.0635
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1312 0.1312
Loa Loa (eye worm) hypothetical protein 0.0119 0.1655 0.3784
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.002 0.0201 0.1714
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0657 0.0657
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0051 0.0657 0.0657
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0048 0.0048
Brugia malayi hypothetical protein 0.005 0.0635 0.1909
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0012 0.0074 0.0635
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0048 0.011
Giardia lamblia AAA family ATPase 0.0052 0.0662 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0048 0.0048
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1447 0.3308
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0087 0.1173 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.024 0.0549
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.032 0.0733
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0048 0.0214
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0135 0.1221
Onchocerca volvulus 0.0012 0.0074 0.0331
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0285 0.1267
Brugia malayi follicle stimulating hormone receptor 0.0233 0.3325 1
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0036 0.0426 0.0426
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.162 0.3703
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.024 0.2169
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0135 0.0817
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0048 0.0048
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0048 0.0214
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0024 0.0024
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1918 0.1918
Loa Loa (eye worm) hypothetical protein 0.0096 0.1312 0.3
Echinococcus multilocularis ceramide kinase 0.0012 0.0074 0.0074
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0074 0.0635
Schistosoma mansoni hypothetical protein 0.0119 0.1655 0.1655
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0135 1
Echinococcus granulosus ceramide kinase 0.0012 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Echinococcus granulosus expressed protein 0.0008 0.0022 0.0022
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0539 0.0539
Entamoeba histolytica hypothetical protein 0.0043 0.0539 0.1233
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0074 0.0635
Brugia malayi map kinase activated protein kinase protein 2 0.018 0.2552 0.7674
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0048 0.0048
Brugia malayi Doublecortin family protein 0.0119 0.1655 0.4978
Brugia malayi EGF-like domain containing protein 0.0008 0.0024 0.0074
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0154 0.0932
Echinococcus granulosus protein jagged 2 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Leishmania major hypothetical protein, conserved 0.0012 0.0074 0.0672
Echinococcus multilocularis sphingosine kinase 1 0.0304 0.4374 0.4374
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0135 0.1221
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0048 0.0048
Schistosoma mansoni cpg binding protein 0.003 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0048 0.0048
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.003 0.003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.024 0.1483
Brugia malayi Serine/threonine-protein kinase Pim-3 0.016 0.2249 0.6763
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0578 0.1322
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0051 0.0657 0.1503
Schistosoma mansoni hypothetical protein 0.0407 0.5887 0.5887
Trypanosoma brucei trypanothione reductase 0.0046 0.0578 0.5223
Schistosoma mansoni hypothetical protein 0.005 0.0635 0.0635
Plasmodium falciparum LCCL domain-containing protein 0.0119 0.1655 1
Brugia malayi EGF-like domain containing protein 0.0008 0.0024 0.0074
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0285 0.0651
Echinococcus granulosus Vam6:Vps39 protein 0.005 0.0635 0.0635
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0005 0.0005
Schistosoma mansoni rab6-interacting 0.0119 0.1655 0.1655
Schistosoma mansoni polycystin 1-related 0.0119 0.1655 0.1655
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0169 0.2384 0.2384
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1312 0.1312
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.162 0.3703
Mycobacterium ulcerans diacylglycerol kinase 0.0012 0.0074 0.017
Echinococcus granulosus lipoxygenase domain containing protein 0.0119 0.1655 0.1655
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0135 0.1153
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0005 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.014 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0048 0.0145
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0135 0.1221
Schistosoma mansoni hypothetical protein 0.0008 0.0024 0.0024
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0024 0.0074
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0048 0.0145
Brugia malayi hypothetical protein 0.0119 0.1655 0.4978
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0082 0.1107 0.2531
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0135 0.1221
Schistosoma mansoni rap gtpase-activating protein 0.005 0.0635 0.0635
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.024 0.1483
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.024 0.2169
Schistosoma mansoni cpg binding protein 0.003 0.0344 0.0344
Toxoplasma gondii EGF family domain-containing protein 0.0008 0.0024 0.0209
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0285 0.0651
Plasmodium falciparum thioredoxin reductase 0.0046 0.0578 0.3494
Brugia malayi Cadherin domain containing protein 0.0008 0.0024 0.0074
Toxoplasma gondii cell division protein CDC48AP 0.0052 0.0662 0.5643
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0012 0.0074 0.017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0048 0.011
Schistosoma mansoni septate junction protein 0.0008 0.0024 0.0024
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0135 0.1153
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0048 0.0048
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0026 0.0285 0.0651
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0135 0.0309
Entamoeba histolytica hypothetical protein 0.0043 0.0539 0.1233
Echinococcus multilocularis 0.012 0.1672 0.1672
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Brugia malayi hypothetical protein 0.0012 0.0074 0.0224
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0024 0.0074
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.002 0.0201 0.1714
Loa Loa (eye worm) hypothetical protein 0.005 0.0642 0.1469
Schistosoma mansoni sphingoid long chain base kinase 0.0304 0.4374 0.4374
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0008 0.0024 0.0074
Leishmania major diacylglycerol kinase-like protein 0.0012 0.0074 0.0672
Brugia malayi Thioredoxin reductase 0.0046 0.0578 0.1739
Echinococcus granulosus lipoxygenase domain containing protein 0.0119 0.1655 0.1655
Loa Loa (eye worm) hypothetical protein 0.005 0.0635 0.1451
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0135 0.1221
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.011
Schistosoma mansoni microtubule-associated protein tau 0.0687 1 1
Onchocerca volvulus Neurogenic locus notch homolog 0.0008 0.0024 0.0109
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0135 0.1221
Loa Loa (eye worm) hypothetical protein 0.0026 0.0285 0.0651
Brugia malayi CHE-14 protein 0.0041 0.0506 0.1522
Loa Loa (eye worm) hypothetical protein 0.0119 0.1655 0.3784
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0506 0.4316
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0024 0.0024
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0578 0.0578
Loa Loa (eye worm) CAMK/PIM protein kinase 0.016 0.2249 0.5141
Echinococcus granulosus slit 2 protein 0.0008 0.0024 0.0024
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.005 0.0635 0.0635
Echinococcus multilocularis slit 2 protein 0.0008 0.0024 0.0024
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.1447 0.8934
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.018 0.2552 0.2552
Loa Loa (eye worm) hypothetical protein 0.0026 0.0285 0.0651
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0048 0.0145
Echinococcus granulosus neurogenic locus notch protein 4 0.0008 0.0024 0.0024
Onchocerca volvulus 0.0026 0.0285 0.1267
Brugia malayi Protein kinase domain containing protein 0.0051 0.0657 0.1977
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0056
Onchocerca volvulus 0.0023 0.024 0.1068
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.162 0.3703
Echinococcus multilocularis protein patched 0.0041 0.0506 0.0506
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0048 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0048 0.0145
Loa Loa (eye worm) notch protein 0.0008 0.0024 0.0056

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.3109 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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