Detailed information for compound 1524126

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 459.924 | Formula: C26H22ClN3O3
  • H donors: 2 H acceptors: 2 LogP: 4.64 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)Oc1ccc(cc1)CN1C(=O)CNC(=O)[C@H]1Cc1c[nH]c2c1cccc2
  • InChi: 1S/C26H22ClN3O3/c27-19-4-3-5-21(13-19)33-20-10-8-17(9-11-20)16-30-24(26(32)29-15-25(30)31)12-18-14-28-23-7-2-1-6-22(18)23/h1-11,13-14,24,28H,12,15-16H2,(H,29,32)/t24-/m1/s1
  • InChiKey: ZPWAIZHOHKVSOG-XMMPIXPASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei polo-like protein kinase 0.0093 0.0945 1
Schistosoma mansoni slit 0.0026 0.0072 0.0085
Loa Loa (eye worm) hypothetical protein 0.012 0.129 0.3604
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0135 0.0239
Loa Loa (eye worm) notch protein 0.0026 0.0072 0.02
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Echinococcus granulosus geminin 0.0334 0.4045 0.4775
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0162 0.0452
Onchocerca volvulus 0.0029 0.0118 0.0312
Echinococcus multilocularis fat cadherin tumor suppressor 0.0026 0.0072 0.0072
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0031 0.0135 0.0084
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0162 0.1826 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0945 0.3186
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0031 0.0135 0.0239
Brugia malayi EGF-like domain containing protein 0.0026 0.0072 0.02
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0031 0.0135 0.0105
Schistosoma mansoni DNA polymerase eta 0.0044 0.0306 0.0362
Onchocerca volvulus 0.0026 0.0072 0.019
Loa Loa (eye worm) hypothetical protein 0.008 0.0767 0.2142
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0202 0.2338 0.8484
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0107 0.0315
Loa Loa (eye worm) animal heme peroxidase 0.008 0.0767 0.2142
Schistosoma mansoni notch 0.0026 0.0072 0.0085
Loa Loa (eye worm) hypothetical protein 0.0164 0.1856 0.5186
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0279 0.033
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.012 0.1285 0.4479
Entamoeba histolytica heat shock transcription factor, putative 0.0097 0.0994 0.4167
Echinococcus multilocularis neurogenic locus notch protein 0.0026 0.0072 0.0072
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0281 0.1999
Echinococcus granulosus fibropellin Ia 0.0026 0.0072 0.0085
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0058 0.0489 0.4512
Brugia malayi Telomerase reverse transcriptase 0.0227 0.2671 0.7462
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0336 0.0873
Plasmodium vivax geranylgeranyltransferase, putative 0.0031 0.0135 0.0116
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.1574 0.1858
Loa Loa (eye worm) hypothetical protein 0.008 0.0767 0.2142
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0274 0.0637
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0118 0.0139
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0281 0.1999
Trichomonas vaginalis MYB, putative 0.0029 0.0109 0.0007
Giardia lamblia Prenyltransferase 0.0031 0.0135 0.0359
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0279 0.0655
Brugia malayi Blistered cuticle protein 3 0.008 0.0767 0.2142
Echinococcus granulosus Dipeptidyl peptidase 9 0.0058 0.0489 0.0578
Entamoeba histolytica hypothetical protein 0.0071 0.0654 0.269
Brugia malayi hypothetical protein 0.0298 0.3579 1
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0042 0.0281 0.0331
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0281 0.1999
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0162 0.1826 0.6535
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0031 0.0135 0.0105
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0031 0.0135 0.0116
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0031 0.0135 0.0248
Echinococcus multilocularis pyruvate kinase 0.0033 0.0162 0.0162
Brugia malayi Animal haem peroxidase family protein 0.008 0.0767 0.2142
Onchocerca volvulus Peroxidase homolog 0.008 0.0767 0.2032
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0313 0.3773 1
Onchocerca volvulus 0.0026 0.0072 0.019
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0945 0.264
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0031 0.0135 0.0135
Echinococcus multilocularis geminin 0.0334 0.4045 0.4045
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0654 0.0772
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0042 0.0281 0.1999
Loa Loa (eye worm) blistered cuticle protein 3 0.008 0.0767 0.2142
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0162 0.1826 0.6535
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.0822 0.2296
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0213 0.2483 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0767 0.2142
Onchocerca volvulus 0.0042 0.0281 0.0744
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0162 0.1826 1
Schistosoma mansoni hypothetical protein 0.0026 0.0072 0.0085
Brugia malayi hypothetical protein 0.0032 0.0153 0.0428
Toxoplasma gondii RNA-directed DNA polymerase 0.0085 0.0841 0.3036
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0031 0.0135 0.0436
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0042 0.0281 0.0331
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0945 0.3186
Brugia malayi EGF-like domain containing protein 0.0026 0.0072 0.02
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0336 0.0873
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0135 0.0105
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0234 0.0698
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0945 0.3186
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0042 0.0281 0.1999
Loa Loa (eye worm) hypothetical protein 0.0162 0.1826 0.5101
Loa Loa (eye worm) hypothetical protein 0.008 0.0767 0.2142
Loa Loa (eye worm) hypothetical protein 0.0164 0.1856 0.5186
Brugia malayi EGF-like domain containing protein 0.0026 0.0072 0.02
Entamoeba histolytica heat shock transcription factor, putative 0.0097 0.0994 0.4167
Onchocerca volvulus Slit protein homolog 0.0026 0.0072 0.019
Leishmania major pyruvate kinase 0.0033 0.0162 0.0569
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Loa Loa (eye worm) hypothetical protein 0.0298 0.3579 1
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0162 0.0356
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0191 0.2208 0.8814
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0191 0.2208 0.8837
Echinococcus granulosus dna polymerase eta 0.0044 0.0306 0.0362
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0107 0.0315
Giardia lamblia Rab geranylgeranyltransferase 0.0162 0.1826 1
Plasmodium falciparum thioredoxin reductase 0.0084 0.0822 0.4132
Trichomonas vaginalis set domain proteins, putative 0.0232 0.2737 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0767 0.2142
Schistosoma mansoni patched 1 0.0041 0.0274 0.0324
Echinococcus multilocularis peroxidasin 0.008 0.0767 0.0767
Schistosoma mansoni pyruvate kinase 0.0033 0.0162 0.0191
Plasmodium vivax telomerase reverse transcriptase, putative 0.0085 0.0841 0.4247
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0015 0.0043
Onchocerca volvulus Huntingtin homolog 0.012 0.129 0.3419
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0306 0.0856
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0162 0.0452
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0109 0.0007
Onchocerca volvulus 0.008 0.0767 0.2032
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0162 0.0429
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0945 0.2504
Schistosoma mansoni notch 0.0026 0.0072 0.0085
Echinococcus multilocularis neurogenic locus notch protein 0.0026 0.0072 0.0072
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0279 0.0819
Trypanosoma cruzi protein farnesyltransferase, putative 0.0031 0.0135 0.0239
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0654 0.0772
Echinococcus granulosus expressed conserved protein 0.0091 0.091 0.1074
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0135 0.0239
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0107 0.0315
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.1522 0.1797
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0042 0.0281 0.0784
Giardia lamblia Rab geranylgeranyltransferase 0.0042 0.0281 0.1192
Brugia malayi notch-like transmembrane receptor 0.0026 0.0072 0.02
Chlamydia trachomatis pyruvate kinase 0.0033 0.0162 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0213 0.2483 1
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0306 0.2308
Loa Loa (eye worm) hypothetical protein 0.0097 0.0986 0.2753
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0945 0.0945
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.2773 0.7748
Loa Loa (eye worm) animal heme peroxidase 0.008 0.0767 0.2142
Loa Loa (eye worm) hypothetical protein 0.0164 0.1856 0.5186
Brugia malayi CHE-14 protein 0.0041 0.0274 0.0767
Schistosoma mansoni hypothetical protein 0.0071 0.0654 0.0772
Plasmodium falciparum geranylgeranyltransferase, putative 0.0031 0.0135 0.0116
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.038 0.1552
Loa Loa (eye worm) hypothetical protein 0.0031 0.0135 0.0376
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0202 0.2338 0.276
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0042 0.0281 0.1999
Schistosoma mansoni hypothetical protein 0.0026 0.0072 0.0085
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0162 0.1826 0.1826
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0986 0.1163
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0213 0.2483 1
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0058 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.008 0.0767 0.2142
Loa Loa (eye worm) animal heme peroxidase 0.008 0.0767 0.2142
Echinococcus granulosus delta-like protein 1 0.0026 0.0072 0.0085
Brugia malayi glutathione reductase 0.0084 0.0822 0.2296
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0015 0.0043
Loa Loa (eye worm) animal heme peroxidase 0.008 0.0767 0.2142
Onchocerca volvulus Peroxidase homolog 0.008 0.0767 0.2032
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0279 0.0819
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0162 0.0569
Brugia malayi GCC2 and GCC3 family protein 0.0026 0.0072 0.02
Echinococcus granulosus pyruvate kinase 0.0033 0.0162 0.0191
Onchocerca volvulus 0.0026 0.0072 0.019
Leishmania major trypanothione reductase 0.0084 0.0822 0.8516
Loa Loa (eye worm) hypothetical protein 0.008 0.0767 0.2142
Schistosoma mansoni hypothetical protein 0.004 0.0255 0.0301
Schistosoma mansoni hypothetical protein 0.0026 0.0072 0.0085
Loa Loa (eye worm) hypothetical protein 0.008 0.0767 0.2142
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0135 0.0239
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.8471 1
Schistosoma mansoni notch 0.0026 0.0072 0.0085
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0031 0.0135 0.0159
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0162 0.0276
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0097 0.0994 0.2636
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.8471 0.8471
Onchocerca volvulus Huntingtin homolog 0.012 0.129 0.3419
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0279 0.0961
Entamoeba histolytica hypothetical protein 0.0071 0.0654 0.269
Onchocerca volvulus Peroxidasin homolog 0.008 0.0767 0.2032
Echinococcus multilocularis protein jagged 1 0.0026 0.0072 0.0072
Echinococcus granulosus neurogenic locus notch protein 0.0026 0.0072 0.0085
Toxoplasma gondii hypothetical protein 0.0042 0.0281 0.0824
Plasmodium falciparum glutathione reductase 0.0084 0.0822 0.4132
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.0822 0.2985
Plasmodium falciparum pyruvate kinase 0.0033 0.0162 0.0276
Echinococcus granulosus neurogenic locus protein delta 0.0026 0.0072 0.0085
Echinococcus multilocularis dna polymerase eta 0.0044 0.0306 0.0306
Brugia malayi hypothetical protein 0.0071 0.0654 0.1827
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0085 0.0841 0.8754
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0118 0.0118
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0173 0.1969 0.5219
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0234 0.0868
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.038 0.32
Brugia malayi Calcium binding EGF domain containing protein 0.0026 0.0072 0.02
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0945 1
Loa Loa (eye worm) Notch2 0.0026 0.0072 0.02
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.1574 0.1574
Schistosoma mansoni notch 0.0026 0.0072 0.0085
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.2773 0.7748
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0191 0.2208 0.8837
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0034 0.0096
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0162 0.1826 0.2155
Loa Loa (eye worm) hypothetical protein 0.008 0.0767 0.2142
Brugia malayi Animal haem peroxidase family protein 0.008 0.0767 0.2142
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0135 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0945 0.3186
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0118 0.0139
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0162 0.0569
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0042 0.0281 0.097
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0042 0.0281 0.1999
Leishmania major hypothetical protein, conserved 0.005 0.038 0.32
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0945 0.1115
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0058 0.0489 0.4512
Schistosoma mansoni hypothetical protein 0.004 0.0255 0.0301
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0191 0.2208 0.8837
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0162 0.1826 0.6535
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0173 0.1969 0.2324
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0945 0.3952
Loa Loa (eye worm) hypothetical protein 0.012 0.129 0.3604
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0173 0.1969 0.2324
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0945 1
Brugia malayi hypothetical protein 0.012 0.129 0.3604
Loa Loa (eye worm) hypothetical protein 0.0044 0.0313 0.0873
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0162 0.0209
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.1574 0.4397
Loa Loa (eye worm) hypothetical protein 0.0044 0.0306 0.0856
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0115 0.5
Echinococcus granulosus slit 2 protein 0.0026 0.0072 0.0085
Echinococcus multilocularis neurogenic locus notch protein 4 0.0026 0.0072 0.0072
Loa Loa (eye worm) glutathione reductase 0.0084 0.0822 0.2296
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.0822 0.4132
Giardia lamblia Pyruvate kinase 0.0033 0.0162 0.0515
Echinococcus multilocularis neurogenic locus protein delta 0.0026 0.0072 0.0072
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0279 0.0655
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1005 0.1186
Giardia lamblia Myb 1-like protein 0.0029 0.0109 0.0211
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0042 0.0281 0.0281
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0945 0.3186
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0138 0.028
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0281 0.1999
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.152 0.152
Treponema pallidum NADH oxidase 0.0029 0.0115 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0654 0.0654
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0202 0.2338 0.276
Echinococcus granulosus pyruvate kinase 0.0033 0.0162 0.0191
Trypanosoma cruzi protein farnesyltransferase, putative 0.0031 0.0135 0.0239
Echinococcus multilocularis fibropellin Ia 0.0026 0.0072 0.0072
Leishmania major pyruvate kinase 0.0033 0.0162 0.0569
Brugia malayi hypothetical protein 0.0044 0.0313 0.0873
Plasmodium vivax SET domain protein, putative 0.0029 0.0118 0.0017
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0274 0.0324
Brugia malayi Pre-SET motif family protein 0.0029 0.0118 0.0328
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.038 0.1552
Echinococcus granulosus neural cadherin 0.0026 0.0072 0.0085
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0031 0.0135 0.0248
Schistosoma mansoni pyruvate kinase 0.0033 0.0162 0.0191
Schistosoma mansoni hypothetical protein 0.004 0.0255 0.0301
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.038 0.1217
Loa Loa (eye worm) hypothetical protein 0.005 0.038 0.1063
Echinococcus multilocularis notch 0.0026 0.0072 0.0072
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0162 0.0569
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0135 0.0248
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0164 0.1856 0.5186
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0162 0.0569
Schistosoma mansoni hypothetical protein 0.0026 0.0072 0.0085
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0162 0.0452
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0274 0.0767
Onchocerca volvulus 0.008 0.0767 0.2032
Brugia malayi prolyl oligopeptidase family protein 0.0173 0.1969 0.5501
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0031 0.0135 0.0116
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0031 0.0135 0.0116
Schistosoma mansoni hypothetical protein 0.0026 0.0072 0.0085
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0945 0.1115
Onchocerca volvulus Putative cubilin 0.0026 0.0072 0.019
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Toxoplasma gondii hypothetical protein 0.012 0.1285 0.4785
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0085 0.0841 0.8754
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.038 0.1552
Giardia lamblia Kinase, PLK 0.0093 0.0945 0.4978
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0031 0.0135 0.0436
Giardia lamblia Rab geranylgeranyltransferase 0.0031 0.0135 0.0359
Schistosoma mansoni hypothetical protein 0.0026 0.0072 0.0085
Brugia malayi EGF-like domain containing protein 0.0026 0.0072 0.02
Brugia malayi hypothetical protein 0.008 0.0767 0.2142
Trypanosoma brucei lanosterol synthase 0.0031 0.0135 0.0239
Echinococcus granulosus protein jagged 2 0.0026 0.0072 0.0085
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0115 0.0135
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0115 0.5
Schistosoma mansoni hypothetical protein 0.0334 0.4045 0.4775
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Mycobacterium tuberculosis Probable reductase 0.0191 0.2208 0.8837
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0274 0.0324
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0135 0.0105
Echinococcus granulosus protein jagged 2 0.0026 0.0072 0.0085
Loa Loa (eye worm) acetyltransferase 0.0142 0.1574 0.4397
Schistosoma mansoni kinase 0.0047 0.0352 0.0416
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0118 0.0118
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0031 0.0135 0.0116
Onchocerca volvulus 0.0026 0.0072 0.019
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0986 0.0986
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0118 0.0139
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0104 0.0122
Loa Loa (eye worm) hypothetical protein 0.008 0.0767 0.2142
Loa Loa (eye worm) hypothetical protein 0.008 0.0767 0.2142
Brugia malayi Muscle positioning protein 4 0.0026 0.0072 0.02
Schistosoma mansoni notch 0.0026 0.0072 0.0085
Brugia malayi EGF-like domain containing protein 0.0026 0.0072 0.02
Leishmania major DNA polymerase eta, putative 0.0044 0.0306 0.2308
Onchocerca volvulus Chorion peroxidase homolog 0.008 0.0767 0.2032
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0115 0.017
Schistosoma mansoni hypothetical protein 0.004 0.0255 0.0301
Schistosoma mansoni laminin gamma-3 chain 0.0026 0.0072 0.0085
Brugia malayi Delta serrate ligand family protein 0.0026 0.0072 0.02
Loa Loa (eye worm) hypothetical protein 0.0031 0.0135 0.0376
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0115 0.003
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0115 0.0115
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.2373 0.663
Leishmania major geranylgeranyltransferase, putative 0.0031 0.0135 0.0239
Plasmodium falciparum telomerase reverse transcriptase 0.0085 0.0841 0.4247
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0162 0.1826 0.2155
Loa Loa (eye worm) prolyl oligopeptidase 0.0173 0.1969 0.5501
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0202 0.2338 1
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0042 0.0281 0.0784
Echinococcus multilocularis thioredoxin glutathione reductase 0.0084 0.0828 0.0828
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0162 0.0209
Echinococcus granulosus neurogenic locus notch protein 0.0026 0.0072 0.0085
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Onchocerca volvulus 0.0298 0.3579 0.9488
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0109 0.0007
Brugia malayi HSF-type DNA-binding domain containing protein 0.0097 0.0994 0.2778
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0281 0.1999
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.0822 0.8516
Echinococcus multilocularis neural cadherin 0.0026 0.0072 0.0072
Trypanosoma brucei telomerase reverse transcriptase 0.0085 0.0841 0.8754
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0986 0.4129
Brugia malayi MH2 domain containing protein 0.0235 0.2773 0.7748
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0029 0.0109 0.0146
Onchocerca volvulus Peroxidasin homolog 0.008 0.0767 0.2032
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0031 0.0135 0.0376
Brugia malayi EGF-like domain containing protein 0.0026 0.0072 0.02
Entamoeba histolytica hypothetical protein 0.0071 0.0654 0.269
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0026 0.0072 0.0085
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0026 0.0072 0.019
Onchocerca volvulus 0.0026 0.0072 0.019
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0026 0.0072 0.02
Brugia malayi hypothetical protein 0.005 0.038 0.1063
Schistosoma mansoni hypothetical protein 0.0022 0.0027 0.0032
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0058 0.0489 0.4512
Echinococcus multilocularis pyruvate kinase 0.0033 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Entamoeba histolytica hypothetical protein 0.0071 0.0654 0.269
Echinococcus granulosus neurogenic locus notch protein 4 0.0026 0.0072 0.0085
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0107 0.0315
Brugia malayi Peroxidasin 0.008 0.0767 0.2142
Giardia lamblia Telomerase catalytic subunit 0.0085 0.0841 0.4388
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0031 0.0135 0.0105
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0162 0.0452
Onchocerca volvulus 0.008 0.0767 0.2032
Loa Loa (eye worm) hypothetical protein 0.008 0.0767 0.2142
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0031 0.0135 0.0135
Echinococcus multilocularis protein jagged 2 0.0026 0.0072 0.0072
Schistosoma mansoni peroxidasin 0.008 0.0767 0.0905
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0162 0.0452
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0115 0.017
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0191 0.2208 0.8837
Loa Loa (eye worm) hypothetical protein 0.008 0.0767 0.2142
Brugia malayi Animal haem peroxidase family protein 0.008 0.0767 0.2142
Brugia malayi Calcium binding EGF domain containing protein 0.0026 0.0072 0.02
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0986 0.2753
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0274 0.0274
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0162 0.0429
Brugia malayi EGF-like domain containing protein 0.0026 0.0072 0.02
Echinococcus multilocularis expressed conserved protein 0.0091 0.091 0.091
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0031 0.0135 0.0159
Trypanosoma brucei trypanothione reductase 0.0084 0.0822 0.8516
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0031 0.0135 0.0105
Onchocerca volvulus Dual oxidase homolog 0.008 0.0767 0.2032
Loa Loa (eye worm) hypothetical protein 0.0097 0.0994 0.2778
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0027 0.0032
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0058 0.0489 0.1647
Brugia malayi Cadherin domain containing protein 0.0026 0.0072 0.02
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0058 0.0489 0.4512
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0162 0.1826 0.5101
Toxoplasma gondii hypothetical protein 0.0164 0.1856 0.7038
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0945 0.3186
Loa Loa (eye worm) hypothetical protein 0.0033 0.0162 0.0452
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0031 0.0135 0.0105
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Leishmania major DNA polymerase eta, putative 0.0031 0.0138 0.028
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0945 1
Echinococcus multilocularis pyruvate kinase 0.0026 0.0073 0.0073
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0213 0.2483 1
Trypanosoma cruzi lanosterol synthase, putative 0.0031 0.0135 0.0239
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.0525 0.062
Leishmania major telomerase reverse transcriptase, putative 0.0085 0.0841 0.8754
Mycobacterium tuberculosis Probable dehydrogenase 0.0191 0.2208 0.8837
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0173 0.1969 0.1969
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0162 0.0429
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0202 0.2338 0.6533
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0945 0.264
Schistosoma mansoni hypothetical protein 0.0334 0.4045 0.4775
Trypanosoma cruzi lanosterol synthase, putative 0.0031 0.0135 0.0239
Echinococcus granulosus protein jagged 1 0.0026 0.0072 0.0085
Onchocerca volvulus Neurogenic locus notch homolog 0.0026 0.0072 0.019
Schistosoma mansoni peroxidasin 0.008 0.0767 0.0905
Echinococcus granulosus microtubule associated protein 2 0.0677 0.8471 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0274 0.0767
Brugia malayi Cadherin domain containing protein 0.0026 0.0072 0.02
Echinococcus multilocularis protein dispatched 1 0.0047 0.035 0.035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Brugia malayi Pre-SET motif family protein 0.0204 0.2373 0.663
Brugia malayi prolyl oligopeptidase family protein 0.0058 0.0489 0.1367
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0162 0.0199
Loa Loa (eye worm) hypothetical protein 0.008 0.0767 0.2142
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0042 0.0281 0.097
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0306 0.2308
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Loa Loa (eye worm) hypothetical protein 0.0029 0.0118 0.0328
Echinococcus granulosus thioredoxin glutathione reductase 0.0084 0.0828 0.0977
Onchocerca volvulus 0.0232 0.2737 0.7255
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0118 0.0181
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Schistosoma mansoni hypothetical protein 0.0026 0.0072 0.0085
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0162 0.1826 0.5101
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0031 0.0135 0.0159
Echinococcus granulosus peroxidasin 0.008 0.0767 0.0905
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0042 0.0281 0.1069
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.152 0.1794
Echinococcus multilocularis slit 2 protein 0.0026 0.0072 0.0072
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0202 0.2338 0.276
Entamoeba histolytica heat shock transcription factor, putative 0.0097 0.0994 0.4167
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0234 0.0927
Leishmania major farnesyltransferase beta subunit 0.0031 0.0135 0.0239
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0027 0.0027
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0058 0.0489 0.0578
Loa Loa (eye worm) hypothetical protein 0.0051 0.0395 0.1103
Schistosoma mansoni notch 0.0026 0.0072 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0118 0.0139
Brugia malayi Animal haem peroxidase family protein 0.008 0.0767 0.2142
Echinococcus multilocularis protein patched 0.0041 0.0274 0.0274
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0028 0.0107 0.0315
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0118 0.0139
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0058 0.0489 0.4512
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.0222 0.2607 1
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0162 0.1826 0.7775
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.0281 0.1999
Toxoplasma gondii thioredoxin reductase 0.0084 0.0822 0.2958
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0138 0.0262
Echinococcus multilocularis neurogenic locus protein delta 0.0026 0.0072 0.0072
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0115 0.0246
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0031 0.0135 0.0376
Echinococcus granulosus notch 0.0026 0.0072 0.0085
Brugia malayi Calcium binding EGF domain containing protein 0.0026 0.0072 0.02
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0115 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0945 0.3186
Brugia malayi Animal haem peroxidase family protein 0.008 0.0767 0.2142
Schistosoma mansoni septate junction protein 0.0026 0.0072 0.0085
Brugia malayi Thioredoxin reductase 0.0084 0.0822 0.2296
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.038 0.32
Schistosoma mansoni cell polarity protein 0.0026 0.0072 0.0085
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0042 0.0281 0.0281
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0115 0.0321
Echinococcus granulosus protein jagged 1 0.0026 0.0072 0.0085
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0162 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.02
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0042 0.0281 0.0661
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0135 0.0239
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0202 0.2338 0.6533
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0202 0.2338 0.2338
Plasmodium vivax glutathione reductase, putative 0.0084 0.0822 0.4132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0096
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0115 0.0135
Echinococcus multilocularis protein jagged 1 0.0026 0.0072 0.0072
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.038 0.32
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0031 0.0135 0.0376

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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