Detailed information for compound 1542525

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 546.704 | Formula: C31H42N6O3
  • H donors: 2 H acceptors: 4 LogP: 2.13 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(CC1C[C@H](C(=O)N(C(C)C)C(C)C)[C@@]2(N(C1=O)CCc1c2[nH]c2c1cccc2)C)NCCCn1cncc1
  • InChi: 1S/C31H42N6O3/c1-20(2)37(21(3)4)30(40)25-17-22(18-27(38)33-12-8-14-35-16-13-32-19-35)29(39)36-15-11-24-23-9-6-7-10-26(23)34-28(24)31(25,36)5/h6-7,9-10,13,16,19-22,25,34H,8,11-12,14-15,17-18H2,1-5H3,(H,33,38)/t22?,25-,31+/m1/s1
  • InChiKey: DREHXMUMJUNJPF-IFCCTFEESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus g-protein coupled receptor 0.0021 0.007 0.0083
Onchocerca volvulus 0.0021 0.007 0.0066
Echinococcus granulosus heat shock protein 0.002 0.0062 0.0074
Echinococcus multilocularis lamin dm0 0.0011 0.0019 0.0022
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.007 0.0083
Trypanosoma cruzi heat shock protein 85, putative 0.0016 0.0043 0.1549
Mycobacterium ulcerans heat shock protein 90 0.0016 0.0043 0.0274
Echinococcus multilocularis g protein coupled receptor 0.0021 0.007 0.0083
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0016 0.0043 0.009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.007
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0057 0.0246 1
Loa Loa (eye worm) ACC-1 protein 0.0045 0.0185 0.0192
Echinococcus granulosus intermediate filament protein 0.0011 0.0019 0.0022
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.001 0.0013 0.0176
Onchocerca volvulus 0.0021 0.007 0.0066
Schistosoma mansoni opsin-like receptor 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0024 0.0084 0.0087
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0045 0.0185 0.0219
Brugia malayi vab-3 gene. 0.0038 0.0152 0.0157
Brugia malayi Intermediate filament tail domain containing protein 0.0011 0.0019 0.002
Trypanosoma brucei calcium-activated potassium channel, putative 0.0011 0.0018 0.053
Schistosoma mansoni kinase 0.0029 0.0108 0.0129
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.002 0.0065 0.2453
Loa Loa (eye worm) hypothetical protein 0.0045 0.0185 0.0192
Brugia malayi hypothetical protein 0.0021 0.007 0.0072
Schistosoma mansoni neurotransmitter gated ion channel 0.0021 0.0067 0.008
Plasmodium falciparum perforin-like protein 5 0.0157 0.0731 0.5293
Leishmania major DNA polymerase eta, putative 0.0026 0.009 0.3528
Echinococcus granulosus neuropeptide receptor 0.0021 0.007 0.0083
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0045 0.0185 0.0219
Brugia malayi AKH receptor 0.0021 0.007 0.0072
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Brugia malayi hypothetical protein 0.0021 0.0067 0.007
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0021 0.007 0.0083
Schistosoma mansoni twik family of potassium channels-related 0.0011 0.0018 0.0022
Onchocerca volvulus 0.0021 0.0067 0.0064
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Trichomonas vaginalis heat shock protein, putative 0.002 0.0062 0.2124
Schistosoma mansoni loxhd1 0.0291 0.1382 0.1638
Brugia malayi hypothetical protein 0.0021 0.0067 0.007
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0045 0.0185 0.0219
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0021 0.007 0.0072
Brugia malayi chromobox protein homolog 3 0.0024 0.0082 0.0085
Leishmania major hypothetical protein, conserved 0.0011 0.0018 0.053
Echinococcus multilocularis serotonin receptor 0.0021 0.007 0.0083
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0011 0.0018 0.0019
Echinococcus granulosus dro:myosuppressin receptor 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0045 0.0185 0.0192
Brugia malayi G-protein coupled receptor 0.0021 0.007 0.0072
Echinococcus granulosus multidrug resistance protein 1 0.0008 0.0006 0.0007
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0016 0.0043 0.1568
Echinococcus granulosus neuropeptide FF receptor 2 0.0021 0.007 0.0083
Schistosoma mansoni paired box protein pax-6 0.0038 0.0152 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0202 0.8176
Trypanosoma cruzi DNA damage repair protein, putative 0.001 0.0015 0.0389
Trichomonas vaginalis heat shock protein, putative 0.0012 0.0025 0.0859
Plasmodium vivax potassium channel, putative 0.0011 0.0018 0.0133
Plasmodium falciparum DNA repair protein REV1, putative 0.001 0.0015 0.0109
Echinococcus granulosus nAChR subunit 0.0024 0.0084 0.01
Echinococcus granulosus serotonin receptor 0.0021 0.007 0.0083
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.007 0.0072
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0104 0.4078
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Schistosoma mansoni calcium-activated potassium channel 0.0011 0.0018 0.0022
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0091 0.0658
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Plasmodium vivax ornithine aminotransferase, putative 0.001 0.0013 0.0093
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0024 0.0084 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0048 0.1636
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0011 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0202 0.8176
Onchocerca volvulus 0.0011 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.007 0.0083
Echinococcus granulosus chromobox protein 1 0.0042 0.0173 0.0205
Echinococcus granulosus lipoxygenase domain containing protein 0.0291 0.1382 0.1638
Schistosoma mansoni terminal deoxycytidyl transferase 0.0032 0.0123 0.0146
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0066 0.0286 0.2486
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0202 0.8176
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0015 0.0389
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Schistosoma mansoni ran 0.0026 0.0091 0.0108
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.007 0.0083
Loa Loa (eye worm) TWK-7 protein 0.0011 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0235 0.111 1
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0018 0.053
Onchocerca volvulus 0.0038 0.0152 0.0151
Onchocerca volvulus 0.0021 0.007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.007 0.0083
Trypanosoma cruzi DNA polymerase eta, putative 0.0026 0.009 0.3528
Chlamydia trachomatis replicative DNA helicase 0.0235 0.111 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0021 0.007 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0202 0.8176
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0021 0.0067 0.008
Onchocerca volvulus 0.0021 0.007 0.0066
Brugia malayi RNA, U transporter 1 0.0099 0.0448 0.0464
Echinococcus multilocularis nAChR subunit 0.0045 0.0185 0.0219
Echinococcus multilocularis ornithine aminotransferase 0.001 0.0013 0.0015
Schistosoma mansoni ran 0.0026 0.0091 0.0108
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.007 0.0083
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.007 0.0083
Echinococcus granulosus glycine receptor subunit alpha 1 0.0045 0.0185 0.0219
Loa Loa (eye worm) hypothetical protein 0.0045 0.0185 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0202 0.8176
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0011 0.0018 0.0019
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0008 0.0006 0.0212
Echinococcus multilocularis chromobox protein 1 0.0042 0.0173 0.0205
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0011 0.0018 0.0019
Plasmodium falciparum heat shock protein 90, putative 0.0008 0.0006 0.0041
Brugia malayi hypothetical protein 0.0011 0.0018 0.0019
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0067 0.0294 0.0845
Treponema pallidum recombinase A 0.0066 0.0286 0.2275
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0014 0.0035 0.0472
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0008 0.0006 0.0212
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0091 0.0108
Leishmania major DNA damage repair protein, putative 0.001 0.0015 0.0389
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0021 0.0067 0.007
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0045 0.0185 0.0192
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0032 0.0123 0.0146
Schistosoma mansoni hypothetical protein 0.1422 0.6885 0.8164
Toxoplasma gondii ion channel protein 0.0011 0.0018 0.0252
Echinococcus multilocularis heat shock protein 90 0.0016 0.0043 0.0051
Brugia malayi polk-prov protein 0.0026 0.0094 0.0097
Onchocerca volvulus 0.0019 0.0057 0.0053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.007 0.0083
Echinococcus multilocularis potassium channel subfamily K 0.0011 0.0018 0.0022
Schistosoma mansoni nAChR subunit 0.0045 0.0185 0.0219
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Plasmodium falciparum endoplasmin, putative 0.0012 0.0025 0.0183
Echinococcus multilocularis multidrug resistance protein 1 0.0008 0.0006 0.0007
Trypanosoma cruzi DNA repair protein, putative 0.002 0.0065 0.2453
Echinococcus granulosus small conductance calcium activated potassium 0.0288 0.1369 0.1623
Schistosoma mansoni twik family of potassium channels-related 0.0011 0.0018 0.0022
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0008 0.0006 0.0006
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0021 0.007 0.0083
Loa Loa (eye worm) multidrug resistance protein 3 0.0008 0.0006 0.0006
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0021 0.0067 0.008
Onchocerca volvulus 0.0021 0.007 0.0066
Loa Loa (eye worm) intermediate filament protein 0.0011 0.0019 0.002
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.001 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Schistosoma mansoni nAChR subunit 0.0045 0.0185 0.0219
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Toxoplasma gondii ion channel protein 0.0011 0.0018 0.0252
Plasmodium falciparum LCCL domain-containing protein 0.0291 0.1382 1
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0082 0.2784
Loa Loa (eye worm) hypothetical protein 0.0019 0.0057 0.0059
Schistosoma mansoni opsin-like receptor 0.0021 0.007 0.0083
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0021 0.007 0.0083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.007 0.0083
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0008 0.0006 0.0212
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0008 0.0006 0.0212
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0008 0.0006 0.0212
Trypanosoma brucei heat shock protein, putative 0.002 0.0062 0.2364
Trypanosoma brucei heat shock protein, putative 0.002 0.0062 0.2364
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0045 0.0185 0.0192
Echinococcus granulosus paired box protein pax 6 0.0038 0.0152 0.018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.007 0.0083
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Onchocerca volvulus 0.0011 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.0113 0.0516 0.0534
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0008 0.0006 0.0085
Mycobacterium ulcerans transmembrane cation transporter 0.0011 0.0018 0.0051
Onchocerca volvulus 0.0021 0.007 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.007 0.0083
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Echinococcus multilocularis dna polymerase eta 0.0048 0.0199 0.0236
Loa Loa (eye worm) hypothetical protein 0.0045 0.0185 0.0192
Echinococcus granulosus orexin receptor type 2 0.0021 0.007 0.0083
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0091 0.1083
Schistosoma mansoni amine GPCR 0.0021 0.007 0.0083
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0104 0.3525
Echinococcus multilocularis sex peptide receptor 0.0021 0.007 0.0083
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0008 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0021 0.0067 0.007
Schistosoma mansoni ornithine--oxo-acid transaminase 0.001 0.0013 0.0015
Leishmania major GTP-binding protein, putative 0.0026 0.0091 0.355
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.007
Loa Loa (eye worm) heat shock protein 75 0.0008 0.0006 0.0006
Schistosoma mansoni paired box protein pax-1-related 0.0038 0.0152 0.018
Brugia malayi G protein-coupled receptor F59B2.13 0.0021 0.007 0.0072
Onchocerca volvulus Phospholipase A2 homolog 0.0475 0.2276 0.2353
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.007 0.0083
Schistosoma mansoni multidrug resistance protein 0.0008 0.0006 0.0007
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Echinococcus multilocularis chromobox protein 1 0.0042 0.0173 0.0205
Brugia malayi Tachykinin-like peptides receptor 99D 0.0021 0.007 0.0072
Echinococcus granulosus endoplasmin 0.0016 0.0043 0.0051
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0011 0.0018 0.0019
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0016 0.0043 0.0274
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0008 0.0006 0.0212
Brugia malayi acetyltransferase, GNAT family protein 0.0058 0.025 0.0259
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.007 0.0083
Onchocerca volvulus 0.0079 0.035 0.0357
Brugia malayi hypothetical protein 0.0021 0.0067 0.007
Loa Loa (eye worm) pax transcription factor protein 2 0.1991 0.9654 1
Trypanosoma brucei DNA polymerase IV, putative 0.0048 0.0202 0.8176
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.007 0.0083
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0045 0.0185 0.0192
Onchocerca volvulus Phospholipase A2 homolog 0.0165 0.077 0.0792
Echinococcus granulosus neuropeptide s receptor 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0013 0.003 0.1018
Brugia malayi Cation transporter family protein 0.0079 0.035 0.0363
Brugia malayi 'Paired box' domain containing protein 0.0038 0.0152 0.0157
Onchocerca volvulus 0.0011 0.0018 0.0013
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0045 0.0185 0.0192
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0021 0.0067 0.007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0021 0.0067 0.008
Brugia malayi hypothetical protein 0.0021 0.007 0.0072
Trypanosoma cruzi heat shock protein 85, putative 0.002 0.0062 0.2364
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0045 0.0185 0.0219
Echinococcus multilocularis G-protein coupled receptor, putative 0.0021 0.007 0.0083
Echinococcus granulosus 7tm_1 domain containing protein 0.0021 0.007 0.0083
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0008 0.0006 0.0212
Echinococcus multilocularis allatostatin A receptor 0.0021 0.007 0.0083
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0021 0.007 0.0083
Plasmodium vivax heat shock protein, putative 0.0008 0.0006 0.0041
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.007 0.0083
Entamoeba histolytica serine/threonine protein kinase, putative 0.0057 0.0246 0.3435
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0017 0.005 0.0359
Schistosoma mansoni hypothetical protein 0.0011 0.0018 0.0022
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0113 0.0516 0.0612
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0097
Echinococcus granulosus potassium channel subfamily K 0.0011 0.0018 0.0022
Brugia malayi hypothetical protein 0.0021 0.0067 0.007
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0136 0.0161
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0045 0.0185 0.0192
Schistosoma mansoni acetylcholine receptor subunit beta 0.0021 0.0067 0.008
Trypanosoma cruzi polo-like protein kinase, putative 0.0057 0.0246 1
Echinococcus granulosus paired box gene 3/7 (eyeless, eyegone, twin of eyeless) 0.0038 0.0152 0.018
Loa Loa (eye worm) hypothetical protein 0.0045 0.0185 0.0192
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0021 0.007 0.0072
Plasmodium falciparum heat shock protein 90, putative 0.0008 0.0006 0.0041
Brugia malayi Phospholipase A2 family protein 0.0165 0.077 0.0797
Trypanosoma brucei hypothetical protein, conserved 0.001 0.0015 0.0389
Echinococcus granulosus heat shock protein 90 0.002 0.0062 0.0074
Onchocerca volvulus 0.0024 0.0084 0.0081
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0008 0.0006 0.0007
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1775 0.1839
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Brugia malayi N-terminal motif family protein 0.011 0.0501 0.0519
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0011 0.0018 0.053
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0008 0.0006 0.0007
Entamoeba histolytica Flap nuclease, putative 0.0016 0.0043 0.0605
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0008 0.0006 0.0007
Echinococcus granulosus ornithine aminotransferase 0.001 0.0013 0.0015
Entamoeba histolytica heat shock protein 90, putative 0.002 0.0062 0.0873
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0185 0.0192
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0021 0.007 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0048 0.1636
Plasmodium vivax DNA repair protein REV1, putative 0.001 0.0015 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0105 0.356
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0008 0.0006 0.0007
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0045 0.0185 0.0192
Toxoplasma gondii MAC/Perforin domain-containing protein 0.0157 0.0731 1
Plasmodium falciparum ornithine aminotransferase 0.001 0.0013 0.0093
Onchocerca volvulus 0.0021 0.007 0.0066
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0235 0.111 0.3299
Loa Loa (eye worm) twinkle helicase 0.0067 0.0293 0.0304
Echinococcus granulosus glycine receptor subunit alpha 1 0.0045 0.0185 0.0219
Schistosoma mansoni paired box protein pax-6 0.0038 0.0152 0.018
Trichomonas vaginalis chromobox protein, putative 0.0026 0.0091 0.3083
Echinococcus multilocularis glycine receptor subunit beta 0.0045 0.0185 0.0219
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.001 0.0013 0.0007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0045 0.0185 0.0192
Loa Loa (eye worm) heterochromatin protein 1 0.0042 0.0173 0.0179
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0021 0.007 0.0083
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0173 0.5867
Mycobacterium ulcerans recombinase A 0.0066 0.0286 0.2486
Plasmodium falciparum heat shock protein 90 0.002 0.0062 0.0452
Brugia malayi Doublecortin family protein 0.0291 0.1382 0.1431
Brugia malayi G-protein coupled receptor 0.0021 0.007 0.0072
Plasmodium falciparum multidrug resistance protein 1 0.0008 0.0006 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0246 0.8363
Brugia malayi Dopamine receptor 0.0021 0.007 0.0072
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0113 0.0516 0.0612
Echinococcus multilocularis serotonin receptor 0.0021 0.007 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0246 0.8363
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Onchocerca volvulus 0.0011 0.0018 0.0013
Schistosoma mansoni twik family of potassium channels-related 0.0011 0.0018 0.0022
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0136 0.5412
Schistosoma mansoni calcium-activated potassium channel 0.0288 0.1369 0.1623
Loa Loa (eye worm) flap endonuclease-1 0.0016 0.0043 0.0045
Brugia malayi hypothetical protein 0.0021 0.007 0.0072
Echinococcus multilocularis g protein coupled receptor 0.0021 0.007 0.0083
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0045 0.0185 0.0219
Echinococcus multilocularis twik family of potassium channels 0.0011 0.0018 0.0022
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0024 0.0084 0.0087
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.007 0.0072
Echinococcus multilocularis macrophage expressed protein 0.1422 0.6885 0.8164
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0021 0.007 0.0083
Giardia lamblia Hypothetical protein 0.0011 0.0018 0.0048
Brugia malayi putative neuropeptide receptor 0.0021 0.007 0.0072
Brugia malayi intermediate filament protein 0.0011 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.002
Onchocerca volvulus 0.0038 0.0152 0.0151
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0016 0.0043 0.0037
Echinococcus multilocularis fmrfamide receptor 0.0021 0.007 0.0083
Onchocerca volvulus 0.0021 0.007 0.0066
Schistosoma mansoni growth hormone secretagogue receptor 0.0021 0.007 0.0083
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0021 0.0067 0.007
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0011 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Brugia malayi Importin beta-1 subunit 0.0035 0.0136 0.0141
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0016 0.0043 0.1549
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0008 0.0006 0.0007
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0021 0.007 0.0083
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0021 0.007 0.0072
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.007 0.0083
Echinococcus granulosus neuropeptide receptor A26 0.0021 0.007 0.0083
Toxoplasma gondii perforin-like protein PLP1 0.0157 0.0731 1
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0011 0.0018 0.053
Echinococcus multilocularis paired box protein pax 6 0.0038 0.0152 0.018
Loa Loa (eye worm) hypothetical protein 0.0045 0.0185 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.007 0.0083
Echinococcus granulosus fmrfamide receptor 0.0021 0.007 0.0083
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.007 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0202 0.8176
Brugia malayi ImpB/MucB/SamB family protein 0.0032 0.0123 0.0128
Leishmania major hypothetical protein, conserved 0.0011 0.0018 0.053
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0021 0.007 0.0083
Trypanosoma brucei heat shock protein, putative 0.002 0.0062 0.2364
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Trichomonas vaginalis flap endonuclease-1, putative 0.0016 0.0043 0.1474
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0026 0.009 0.1237
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0018 0.0626
Trichomonas vaginalis ABC transporter, putative 0.0008 0.0006 0.0212
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0094 0.3666
Onchocerca volvulus 0.0021 0.007 0.0066
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0045 0.0185 0.0219
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0067 0.0294 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.007 0.0083
Schistosoma mansoni amine GPCR 0.0021 0.007 0.0083
Plasmodium falciparum perforin-like protein 4 0.0157 0.0731 0.5293
Trypanosoma brucei DNA polymerase IV, putative 0.0048 0.0202 0.8176
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0045 0.0185 0.0219
Onchocerca volvulus Putative nachr subunit 0.0113 0.0516 0.0529
Onchocerca volvulus 0.1991 0.9654 1
Schistosoma mansoni twik family of potassium channels-related 0.0011 0.0018 0.0022
Echinococcus granulosus G protein coupled receptor 139 0.0021 0.007 0.0083
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0008 0.0006 0.0007
Trichomonas vaginalis abcb9, putative 0.0008 0.0006 0.0212
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0038 0.0152 0.0157
Loa Loa (eye worm) hypothetical protein 0.0058 0.025 0.0258
Echinococcus granulosus macrophage expressed protein 0.1422 0.6885 0.8164
Leishmania major DNA polymerase kappa, putative 0.001 0.0015 0.0389
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0008 0.0006 0.0212
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0008 0.0006 0.0007
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.007
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.007 0.0083
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0016 0.0043 0.1568
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0062 0.2364
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0091 0.0094
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0045 0.0185 0.0219
Echinococcus multilocularis musashi 0.0011 0.0019 0.0022
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.007 0.0083
Schistosoma mansoni nAChR subunit 0.0045 0.0185 0.0219
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0048 0.0202 0.6873
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0094 0.3682
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.007 0.0083
Plasmodium falciparum potassium channel 0.0011 0.0018 0.0133
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0185 0.0192
Schistosoma mansoni hypothetical protein 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Trichomonas vaginalis bromodomain-containing protein, putative 0.0017 0.005 0.1686
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.007 0.0083
Plasmodium vivax perforin-like protein 1 0.0157 0.0731 0.5293
Leishmania major DNA polymerase kappa, putative 0.0036 0.0143 0.5712
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0202 0.8176
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0021 0.007 0.0083
Echinococcus multilocularis Polycystic kidney disease protein 0.0291 0.1382 0.1638
Schistosoma mansoni biogenic amine receptor 0.0021 0.007 0.0083
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.007 0.0083
Schistosoma mansoni hypothetical protein 0.0291 0.1382 0.1638
Brugia malayi ABC transporter family protein 0.0008 0.0006 0.0006
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0199 0.8039
Trypanosoma cruzi heat shock protein 90, putative 0.0016 0.0043 0.1549
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0045 0.0185 0.0219
Onchocerca volvulus Retinal homeobox protein Rx homolog 0.0038 0.0152 0.0151
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0246 0.8363
Trypanosoma cruzi heat shock protein 85, putative 0.002 0.0062 0.2364
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0235 0.111 1
Echinococcus granulosus flap endonuclease 1 0.0016 0.0043 0.0051
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0032 0.0123 0.0146
Schistosoma mansoni multidrug resistance protein 0.0008 0.0006 0.0007
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.007 0.0083
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0011 0.0018 0.0019
Echinococcus granulosus arachidonate 5 lipoxygenase 0.174 0.8433 1
Plasmodium vivax potassium channel, putative 0.0011 0.0018 0.0133
Echinococcus multilocularis orexin receptor type 2 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.011 0.0501 0.0519
Loa Loa (eye worm) hypothetical protein 0.0038 0.0152 0.0157
Loa Loa (eye worm) vab-3 0.0038 0.0152 0.0157
Loa Loa (eye worm) hypothetical protein 0.0035 0.0136 0.0141
Onchocerca volvulus 0.0045 0.0185 0.0186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Echinococcus multilocularis paired box protein pax 6 0.0038 0.0152 0.018
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0011 0.0018 0.0257
Entamoeba histolytica Ran family GTPase 0.0026 0.0091 0.127
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0091 0.355
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0045 0.0185 0.0219
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0024 0.0084 0.01
Echinococcus multilocularis calcium activated potassium channel variant 0.0011 0.0018 0.0022
Giardia lamblia Heat shock protein HSP 90-alpha 0.0016 0.0043 0.0398
Schistosoma mansoni neuropeptide receptor 0.0021 0.007 0.0083
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0008 0.0006 0.0212
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0045 0.0185 0.0192
Brugia malayi Cation transporter family protein 0.0045 0.0185 0.0192
Echinococcus granulosus glycine receptor subunit alpha 1 0.0045 0.0185 0.0219
Echinococcus granulosus hypothetical protein 0.0021 0.007 0.0083
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0045 0.0185 0.0192
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.007 0.0083
Schistosoma mansoni calcium-activated potassium channel 0.0209 0.0984 0.1167
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0016 0.0043 0.1568
Echinococcus multilocularis Aminotransferase class III 0.001 0.0013 0.0015
Echinococcus multilocularis dro:myosuppressin receptor 0.0021 0.007 0.0083
Schistosoma mansoni chromobox protein 0.0042 0.0173 0.0205
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0008 0.0006 0.0212
Giardia lamblia Kinase, PLK 0.0057 0.0246 0.3294
Loa Loa (eye worm) endoplasmin 0.002 0.0062 0.0065
Trypanosoma brucei chrX additional, unordered contigs 0.001 0.0015 0.0389
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0017 0.005 0.0678
Schistosoma mansoni biogenic amine receptor 0.0021 0.007 0.0083
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0202 0.8176
Echinococcus granulosus dna polymerase kappa 0.0048 0.0202 0.024
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Echinococcus granulosus lamin dm0 0.0011 0.0019 0.0022
Brugia malayi paired box protein 0.0038 0.0152 0.0157
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0045 0.0185 0.0192
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0032 0.0123 0.0128
Schistosoma mansoni rab6-interacting 0.0291 0.1382 0.1638
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0013 0.003 0.1018
Brugia malayi neuropeptide F receptor 0.0021 0.007 0.0072
Loa Loa (eye worm) paired box protein 0.0038 0.0152 0.0157
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0079 0.035 0.0363
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0094 0.3682
Onchocerca volvulus 0.0021 0.007 0.0066
Plasmodium vivax perforin-like protein 2 0.0157 0.0731 0.5293
Schistosoma mansoni paired box protein pax-6 0.0038 0.0152 0.018
Schistosoma mansoni heat shock protein 0.0008 0.0006 0.0007
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0008 0.0006 0.0007
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0045 0.0185 0.0192
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Onchocerca volvulus Serine\/threonine kinase homolog 0.0057 0.0246 0.0249
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0246 0.8363
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0045 0.0185 0.0192
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0021 0.007 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0202 0.8176
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.007 0.0083
Onchocerca volvulus 0.0021 0.007 0.0066
Schistosoma mansoni nAChR subunit 0.0021 0.0067 0.008
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.001 0.0013 0.0007
Brugia malayi neuropeptide F receptor 0.0021 0.007 0.0072
Entamoeba histolytica P-glyco protein 6, putative 0.0008 0.0006 0.0087
Brugia malayi hypothetical protein 0.0021 0.007 0.0072
Trypanosoma cruzi heat shock protein 90, putative 0.0012 0.0023 0.0723
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.007 0.0083
Onchocerca volvulus 0.0045 0.0185 0.0186
Onchocerca volvulus 0.0011 0.0019 0.0014
Loa Loa (eye worm) doublecortin family protein 0.0291 0.1382 0.1431
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0021 0.007 0.0083
Echinococcus granulosus chromobox protein 1 0.0042 0.0173 0.0205
Trypanosoma cruzi ion transport protein, putative 0.0011 0.0018 0.053
Loa Loa (eye worm) hypothetical protein 0.0045 0.0185 0.0192
Entamoeba histolytica hypothetical protein 0.0024 0.0084 0.1174
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0185 0.0192
Echinococcus multilocularis ATP binding cassette sub family B 0.0008 0.0006 0.0007
Brugia malayi hypothetical protein 0.0021 0.007 0.0072
Onchocerca volvulus 0.0021 0.007 0.0066
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0091 0.355
Echinococcus granulosus lamin 0.0011 0.0019 0.0022
Echinococcus granulosus glycine receptor subunit beta 0.0045 0.0185 0.0219
Brugia malayi Gooseberry protein 0.0038 0.0152 0.0157
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Schistosoma mansoni calcium-activated potassium channel 0.0011 0.0018 0.0022
Onchocerca volvulus 0.0021 0.007 0.0066
Echinococcus multilocularis geminin 0.0205 0.0962 0.1141
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0058 0.025 0.0296
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0202 0.8176
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0044 0.018 0.2508
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0021 0.007 0.0072
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0008 0.0006 0.0212
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0084 0.0087
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.007
Loa Loa (eye worm) TWK-28 protein 0.0011 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Trypanosoma brucei unspecified product 0.0022 0.0075 0.2869
Plasmodium vivax flap endonuclease 1, putative 0.0016 0.0043 0.0314
Echinococcus granulosus RUN 0.0291 0.1382 0.1638
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0026 0.0091 0.0088
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0021 0.0067 0.007
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0104 0.3525
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.007 0.0083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.007 0.0083
Schistosoma mansoni neuropeptide receptor 0.0021 0.007 0.0083
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.007 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0018 0.053
Plasmodium vivax endoplasmin, putative 0.002 0.0062 0.0452
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.007 0.0083
Trypanosoma brucei unspecified product 0.0022 0.0075 0.2869
Onchocerca volvulus 0.0021 0.007 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.007 0.0083
Schistosoma mansoni Replicative DNA helicase 0.0235 0.111 0.1317
Echinococcus granulosus neuropeptide receptor 0.0021 0.007 0.0083
Brugia malayi putative neuropeptide receptor NPR1 0.0021 0.007 0.0072
Onchocerca volvulus 0.0011 0.0018 0.0013
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0011 0.0018 0.0019
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0091 0.0094
Schistosoma mansoni lipoxygenase 0.174 0.8433 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0021 0.0067 0.008
Schistosoma mansoni lamin 0.0011 0.0019 0.0022
Loa Loa (eye worm) ACC-1 protein 0.0045 0.0185 0.0192
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0113 0.0516 0.0612
Schistosoma mansoni nAChR subunit 0.0045 0.0185 0.0219
Giardia lamblia Heat shock protein HSP 90-alpha 0.002 0.0062 0.0677
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0091 0.1244
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0011 0.0018 0.0019
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.007 0.0083
Chlamydia trachomatis hypothetical protein 0.0157 0.0731 0.6566
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.007 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0202 0.8176
Brugia malayi hypothetical protein 0.0021 0.007 0.0072
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.007
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0045 0.0185 0.0219
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.011 0.0503 0.0521
Trichomonas vaginalis heat shock protein, putative 0.0016 0.0043 0.1458
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Trichomonas vaginalis ran, putative 0.0026 0.0091 0.3093
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.007 0.0083
Brugia malayi excitatory GABA receptor EXP-1A 0.0045 0.0185 0.0192
Brugia malayi Endoplasmin precursor 0.002 0.0062 0.0065
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0011 0.0018 0.0019
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Plasmodium vivax heat shock protein 90, putative 0.0008 0.0006 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0246 0.8363
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0008 0.0006 0.0212
Trypanosoma brucei heat shock protein, putative 0.002 0.0062 0.2364
Plasmodium falciparum perforin-like protein 2 0.0157 0.0731 0.5293
Loa Loa (eye worm) hypothetical protein 0.0079 0.035 0.0363
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0011 0.0018 0.0019
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0011 0.0018 0.0022
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0021 0.007 0.0083
Schistosoma mansoni endoplasmin 0.002 0.0062 0.0074
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0006
Echinococcus granulosus g protein coupled receptor 0.0021 0.007 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0082 0.2784
Entamoeba histolytica hypothetical protein 0.0044 0.018 0.2508
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.007 0.0083
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0021 0.007 0.0083
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0011 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0475 0.2276 0.2358
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0008 0.0006 0.0212
Loa Loa (eye worm) hypothetical protein 0.0045 0.0185 0.0192
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.007
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0008 0.0006 0.0024
Plasmodium vivax multidomain scavenger receptor, putative 0.0291 0.1382 1
Echinococcus granulosus glycine receptor subunit beta 0.0045 0.0185 0.0219
Echinococcus multilocularis snurportin 1 0.0372 0.1775 0.2105
Schistosoma mansoni alpha-1 adrenergic receptor 0.0021 0.007 0.0083
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0183 0.7363
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0008 0.0006 0.0212
Echinococcus multilocularis g protein coupled receptor 0.0021 0.007 0.0083
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.007 0.0083
Trypanosoma brucei heat shock protein, putative 0.002 0.0062 0.2364
Loa Loa (eye worm) hypothetical protein 0.0024 0.0084 0.0087
Brugia malayi Serotonin receptor 0.0021 0.007 0.0072
Brugia malayi hypothetical protein 0.0291 0.1382 0.1431
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Plasmodium falciparum histone acetyltransferase GCN5 0.0016 0.0043 0.0309
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Entamoeba histolytica hypothetical protein 0.0028 0.0104 0.1448
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.007 0.0083
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0021 0.007 0.0083
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.001 0.0013 0.0013
Trichomonas vaginalis chromobox protein, putative 0.0026 0.0091 0.3083
Echinococcus granulosus nAChR subunit 0.0045 0.0185 0.0219
Onchocerca volvulus 0.0291 0.1382 0.1426
Treponema pallidum replicative DNA helicase (dnaB) 0.0235 0.111 1
Brugia malayi sulfakinin receptor protein 0.0021 0.007 0.0072
Schistosoma mansoni nAChR subunit 0.0045 0.0185 0.0219
Trypanosoma cruzi DNA repair protein, putative 0.002 0.0065 0.2453
Leishmania major p-glycoprotein 0.0008 0.0006 0.0024
Echinococcus multilocularis potassium channel subfamily K 8 0.0011 0.0018 0.0022
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0008 0.0006 0.0007
Giardia lamblia DNA repair protein RAD52 0.0154 0.0716 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0045 0.0185 0.0192
Plasmodium vivax multidrug resistance protein 1, putative 0.0008 0.0006 0.0045
Brugia malayi paired box pox-meso protein 0.0038 0.0152 0.0157
Loa Loa (eye worm) hypothetical protein 0.0038 0.0152 0.0157
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Mycobacterium ulcerans ion transport protein 0.0011 0.0018 0.0051
Trypanosoma cruzi Heat shock protein 83, putative 0.002 0.0062 0.2364
Echinococcus multilocularis multidrug resistance protein 1 0.0008 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0045 0.0185 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0143 0.5712
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.007 0.0083
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.007 0.0083
Brugia malayi follicle stimulating hormone receptor 0.0114 0.0519 0.0538
Plasmodium falciparum flap endonuclease 1 0.0016 0.0043 0.0314
Onchocerca volvulus 0.0045 0.0185 0.0186
Echinococcus multilocularis lipoxygenase domain containing protein 0.0291 0.1382 0.1638
Trichomonas vaginalis heat shock protein, putative 0.0008 0.0006 0.0193
Schistosoma mansoni neuropeptide receptor 0.0021 0.007 0.0083
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0021 0.007 0.0083
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0008 0.0006 0.0212
Giardia lamblia Histone acetyltransferase GCN5 0.0016 0.0043 0.0394
Echinococcus granulosus snurportin 1 0.0372 0.1775 0.2105
Echinococcus multilocularis paired box protein pax 6 0.0038 0.0152 0.018
Brugia malayi G protein-coupled receptor 0.0021 0.007 0.0072
Loa Loa (eye worm) hypothetical protein 0.0024 0.0084 0.0087
Echinococcus granulosus twik family of potassium channels 0.0011 0.0018 0.0022
Echinococcus granulosus somatostatin receptor 0.0021 0.007 0.0083
Schistosoma mansoni amine GPCR 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0038 0.0152 0.0157
Loa Loa (eye worm) GABA receptor subunit 0.0024 0.0084 0.0087
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Brugia malayi GnHR receptor homolog 0.0021 0.007 0.0072
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0021 0.007 0.0083
Onchocerca volvulus 0.0291 0.1382 0.1426
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0067 0.007
Schistosoma mansoni lamin 0.0011 0.0019 0.0022
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.0199 0.0206
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0011 0.0018 0.0022
Schistosoma mansoni adenoreceptor 0.0021 0.007 0.0083
Brugia malayi hypothetical protein 0.0011 0.0018 0.0019
Leishmania major importin beta-1 subunit, putative 0.0028 0.0104 0.4078
Mycobacterium ulcerans hypothetical protein 0.001 0.0015 0.002
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0113 0.0516 0.0612
Mycobacterium ulcerans DNA polymerase IV 0.0048 0.0202 0.1724
Entamoeba histolytica P-glycoprotein-2 0.0008 0.0006 0.0087
Trichomonas vaginalis heat shock protein, putative 0.0016 0.0043 0.1458
Giardia lamblia DINP protein human, muc B family 0.0036 0.0143 0.1825
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Echinococcus multilocularis RUN 0.0291 0.1382 0.1638
Trichomonas vaginalis endoplasmin, putative 0.0012 0.0025 0.0859
Echinococcus granulosus dna polymerase eta 0.0048 0.0199 0.0236
Loa Loa (eye worm) hypothetical protein 0.0045 0.0185 0.0192
Echinococcus multilocularis endoplasmin 0.0016 0.0043 0.0051
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Echinococcus granulosus heat shock protein 90 0.0016 0.0043 0.0051
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0113 0.0516 0.0612
Leishmania major DNA polymerase eta, putative 0.0048 0.0199 0.8039
Echinococcus multilocularis heat shock protein 0.002 0.0062 0.0074
Onchocerca volvulus 0.0079 0.035 0.0357
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0105 0.356
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0094 0.3682
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0045 0.0185 0.0219
Schistosoma mansoni chromobox protein 0.0042 0.0173 0.0205
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0008 0.0006 0.0007
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0173 0.5867
Echinococcus granulosus importin subunit beta 1 0.0035 0.0136 0.0161
Loa Loa (eye worm) hypothetical protein 0.0045 0.0185 0.0192
Entamoeba histolytica heat shock protein 90, putative 0.002 0.0062 0.0873
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0016 0.0043 0.0051
Echinococcus granulosus lipoxygenase domain containing protein 0.0291 0.1382 0.1638
Trichomonas vaginalis ABC transporter, putative 0.0008 0.0006 0.0212
Trypanosoma brucei DNA damage repair protein, putative 0.001 0.0015 0.0389
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0045 0.0185 0.0192
Echinococcus granulosus 7TM GPCR rhodopsin 0.0021 0.007 0.0083
Echinococcus granulosus peptide allatostatin:somatostatin 0.0021 0.007 0.0083
Schistosoma mansoni nAChR subunit 0.0045 0.0185 0.0219
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0036 0.0143 0.0137
Loa Loa (eye worm) hypothetical protein 0.0045 0.0185 0.0192
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0021 0.007 0.0083
Onchocerca volvulus 0.0011 0.0018 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.007 0.0083
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0021 0.0067 0.008
Brugia malayi Flap endonuclease-1 0.0016 0.0043 0.0045
Schistosoma mansoni myosin xvIII 0.0021 0.007 0.0083
Giardia lamblia Flap structure-specific endonuclease 0.0016 0.0043 0.0404
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0013 0.003 0.1018
Trichomonas vaginalis ABC transporter, putative 0.0008 0.0006 0.0212
Echinococcus multilocularis neuropeptide s receptor 0.0021 0.007 0.0083
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0011 0.0018 0.0019
Leishmania major calcium/potassium channel (CAKC), putative 0.0011 0.0018 0.053
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0113 0.0516 0.0534
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0036 0.0143 0.5712
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.007 0.0083
Schistosoma mansoni hypothetical protein 0.0205 0.0962 0.1141
Brugia malayi Cation transporter family protein 0.0045 0.0185 0.0192
Plasmodium falciparum potassium channel 0.0011 0.0018 0.0133
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0079 0.035 0.0416
Plasmodium falciparum perforin-like protein 1 0.0157 0.0731 0.5293
Schistosoma mansoni DNA polymerase eta 0.0048 0.0199 0.0236
Plasmodium vivax perforin-like protein 5 0.0157 0.0731 0.5293
Schistosoma mansoni hypothetical protein 0.0021 0.007 0.0083
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0136 0.1856
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0045 0.0185 0.0219
Schistosoma mansoni twik family of potassium channels-related 0.0011 0.0018 0.0022
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0246 0.8363
Schistosoma mansoni hypothetical protein 0.0205 0.0962 0.1141
Schistosoma mansoni nAChR subunit 0.0021 0.0067 0.008
Echinococcus granulosus tachykinin peptides receptor 99D 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.007
Schistosoma mansoni rab6-interacting 0.0291 0.1382 0.1638
Trypanosoma cruzi polo-like protein kinase, putative 0.0057 0.0246 1
Schistosoma mansoni histamine h1 receptor 0.0021 0.007 0.0083
Schistosoma mansoni polycystin 1-related 0.0291 0.1382 0.1638
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0246 0.8363
Echinococcus granulosus multidrug resistance protein 1 0.0008 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0099 0.0448 0.0464
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.007
Schistosoma mansoni acetylcholine receptor-related 0.0021 0.0067 0.008
Echinococcus multilocularis dna polymerase kappa 0.0048 0.0202 0.024
Entamoeba histolytica P-glycoprotein-5 0.0008 0.0006 0.0087
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0045 0.0185 0.0192
Brugia malayi hypothetical protein 0.0021 0.007 0.0072
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0057 0.0246 0.0292
Trichomonas vaginalis abcb9, putative 0.0008 0.0006 0.0212
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0091 0.0658
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0067 0.0294 0.0288
Trichomonas vaginalis DNA polymerase eta, putative 0.0048 0.0202 0.6873
Schistosoma mansoni twik family of potassium channels-related 0.0011 0.0018 0.0022
Schistosoma mansoni DNA polymerase IV / kappa 0.001 0.0015 0.0018
Brugia malayi Melatonin receptor type 1A 0.0021 0.007 0.0072
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0008 0.0006 0.0212
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0008 0.0006 0.0007
Onchocerca volvulus 0.0021 0.007 0.0066
Echinococcus granulosus Aminotransferase class III 0.001 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Plasmodium falciparum importin beta, putative 0.0035 0.0136 0.0982
Leishmania major potassium channel subunit-like protein 0.0011 0.0018 0.053
Trypanosoma brucei heat shock protein, putative 0.002 0.0062 0.2364
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Echinococcus granulosus g protein coupled receptor 0.0021 0.007 0.0083
Trichomonas vaginalis taga, putative 0.0008 0.0006 0.0212
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0008 0.0006 0.0212
Brugia malayi Hsp90 protein 0.0008 0.0006 0.0006
Schistosoma mansoni importin beta-1 0.0035 0.0136 0.0161
Plasmodium vivax perforin-like protein 3 0.0157 0.0731 0.5293
Schistosoma mansoni intermediate filament proteins 0.0011 0.0019 0.0022
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.007 0.0083
Echinococcus granulosus paired box protein pax 1 0.0038 0.0152 0.018
Onchocerca volvulus 0.0008 0.0006 0.0001
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0113 0.0516 0.0534
Toxoplasma gondii ImpB/MucB/SamB family protein 0.001 0.0015 0.0205
Schistosoma mansoni hypothetical protein 0.0021 0.007 0.0083
Echinococcus multilocularis fmrfamide receptor 0.0021 0.007 0.0083
Echinococcus multilocularis neuropeptide receptor A26 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Loa Loa (eye worm) hypothetical protein 0.0045 0.0185 0.0192
Toxoplasma gondii heat shock protein 90, putative 0.002 0.0062 0.0854
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Loa Loa (eye worm) hypothetical protein 0.0165 0.077 0.0797
Entamoeba histolytica P-glycoprotein 5, putative 0.0008 0.0006 0.0087
Trypanosoma brucei unspecified product 0.0044 0.0183 0.7363
Onchocerca volvulus 0.0079 0.035 0.0357
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0154 0.0716 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0024 0.0082 0.0079
Brugia malayi hypothetical protein 0.0021 0.007 0.0072
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Echinococcus granulosus twik family of potassium channels 0.0011 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Loa Loa (eye worm) hypothetical protein 0.0291 0.1382 0.1431
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0067 0.007
Echinococcus multilocularis neuropeptide receptor 0.0021 0.007 0.0083
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0008 0.0006 0.0212
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0013 0.003 0.1018
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0091 0.355
Schistosoma mansoni neurotransmitter gated ion channel 0.0024 0.0084 0.01
Onchocerca volvulus 0.0021 0.007 0.0066
Schistosoma mansoni hypothetical protein 0.0372 0.1775 0.2105
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0202 0.8176
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.007 0.0072
Mycobacterium leprae Conserved hypothetical protein 0.0693 0.334 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Brugia malayi Dopamine receptor protein 1 0.0021 0.007 0.0072
Trypanosoma cruzi DNA damage repair protein, putative 0.001 0.0015 0.0389
Plasmodium vivax heat shock protein 86, putative 0.002 0.0062 0.0452
Plasmodium falciparum perforin-like protein 3 0.0157 0.0731 0.5293
Brugia malayi Dopamine receptor protein 2 0.0021 0.007 0.0072
Echinococcus granulosus g protein coupled receptor 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.007
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0066 0.0286 0.082
Trypanosoma brucei polo-like protein kinase 0.0057 0.0246 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0199 0.0206
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0185 0.0192
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0008 0.0006 0.0212
Loa Loa (eye worm) TYRA-2 protein 0.0021 0.007 0.0072
Echinococcus multilocularis heat shock protein 90 0.002 0.0062 0.0074
Trypanosoma brucei heat shock protein 90, putative 0.002 0.0062 0.2364
Loa Loa (eye worm) hypothetical protein 0.0024 0.0084 0.0087
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0045 0.0185 0.0219
Brugia malayi multidrug resistance protein 3 0.0008 0.0006 0.0006
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0021 0.007 0.0072
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0024 0.0084 0.0087
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.001 0.0013 0.0007
Onchocerca volvulus 0.0011 0.0019 0.0014
Trypanosoma brucei Heat shock protein 83, putative 0.002 0.0062 0.2364
Echinococcus granulosus histone acetyltransferase KAT2B 0.0017 0.005 0.0059
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0114 0.0519 0.0538
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0021 0.007 0.0072
Schistosoma mansoni amine GPCR 0.0021 0.007 0.0083
Schistosoma mansoni neuropeptide f receptor 76f 0.0021 0.007 0.0083
Trypanosoma brucei heat shock protein, putative 0.002 0.0062 0.2364
Echinococcus granulosus potassium channel subfamily K 8 0.0011 0.0018 0.0022
Onchocerca volvulus 0.0011 0.0018 0.0013
Onchocerca volvulus 0.0021 0.0067 0.0064
Schistosoma mansoni twik family of potassium channels-related 0.0011 0.0018 0.0022
Trypanosoma cruzi heat shock protein 85, putative 0.002 0.0062 0.2364
Chlamydia trachomatis recombinase RecA 0.0066 0.0286 0.2531
Brugia malayi larval opioid receptor 0.0021 0.007 0.0072
Schistosoma mansoni heat shock protein 0.002 0.0062 0.0074
Entamoeba histolytica acetyltransferase, GNAT family 0.0016 0.0043 0.0595
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0024 0.0084 0.01
Loa Loa (eye worm) uncoordinated protein 58 0.0011 0.0018 0.0019
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.174 0.8433 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.007
Trypanosoma brucei heat shock protein 90, putative 0.002 0.0062 0.2364
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0045 0.0185 0.0219
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.0199 0.8039
Echinococcus multilocularis flap endonuclease 1 0.0016 0.0043 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Brugia malayi hypothetical protein 0.0021 0.007 0.0072
Plasmodium vivax importin-beta 2, putative 0.0035 0.0136 0.0982
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.007
Loa Loa (eye worm) acetylcholine receptor protein 0.0021 0.0067 0.007
Echinococcus multilocularis neuropeptide receptor 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Entamoeba histolytica P-glycoprotein-2 0.0008 0.0006 0.0087
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0246 0.0292
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0058 0.025 0.0296
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Echinococcus granulosus paired box protein pax 6 0.0038 0.0152 0.018
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0113 0.0516 0.0612
Trypanosoma brucei DNA damage repair protein, putative 0.001 0.0015 0.0389
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0011 0.0018 0.053
Echinococcus multilocularis lipoxygenase domain containing protein 0.0291 0.1382 0.1638
Echinococcus multilocularis G protein coupled receptor 139 0.0021 0.007 0.0083
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0011 0.0018 0.0012
Schistosoma mansoni twik family of potassium channels-related 0.0011 0.0018 0.0022
Loa Loa (eye worm) heat shock protein 90 0.002 0.0062 0.0065
Loa Loa (eye worm) hypothetical protein 0.0068 0.0299 0.031
Echinococcus granulosus histone acetyltransferase KAT2B 0.0057 0.0242 0.0287
Schistosoma mansoni multidrug resistance protein 0.0008 0.0006 0.0007
Schistosoma mansoni hypothetical protein 0.0288 0.1369 0.1623
Echinococcus multilocularis twik family of potassium channels 0.0011 0.0018 0.0022
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0104 0.3525
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0032 0.0123 0.0146
Leishmania major ion transport protein-like protein 0.0011 0.0018 0.053
Onchocerca volvulus 0.0021 0.0067 0.0064
Schistosoma mansoni hypothetical protein 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Trichomonas vaginalis abcb9, putative 0.0008 0.0006 0.0212
Brugia malayi heat shock protein 90 0.002 0.0062 0.0065
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0011 0.0018 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.007 0.0083
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0011 0.0018 0.053
Brugia malayi hypothetical protein 0.0291 0.1382 0.1431
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0079 0.035 0.0416
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0011 0.0018 0.0019
Brugia malayi ORL1-like opioid receptor 0.0021 0.007 0.0072
Schistosoma mansoni endoplasmin 0.002 0.0062 0.0074
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Echinococcus multilocularis small conductance calcium activated potassium 0.0288 0.1369 0.1623
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.0067 0.007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0084 0.0087
Echinococcus granulosus calcium activated potassium channel variant 0.0011 0.0018 0.0022
Echinococcus multilocularis lamin 0.0011 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0011 0.0018 0.0019
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0008 0.0006 0.0085
Loa Loa (eye worm) hypothetical protein 0.0288 0.1369 0.1418
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.007
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0008 0.0006 0.0079
Brugia malayi serine/threonine-protein kinase plk-2 0.0057 0.0246 0.0255
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0185 0.0192
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0015 0.0389
Brugia malayi hypothetical protein 0.0021 0.007 0.0072
Brugia malayi Pax transcription factor protein 2 0.1991 0.9654 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0094 0.3666
Schistosoma mansoni lipoxygenase 0.1216 0.5885 0.6979
Echinococcus granulosus allatostatin A receptor 0.0021 0.007 0.0083
Trypanosoma brucei heat shock protein, putative 0.002 0.0062 0.2364
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0045 0.0185 0.0219
Brugia malayi hypothetical protein 0.0021 0.0067 0.007
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0011 0.0018 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.007 0.0083
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0136 0.5412
Plasmodium vivax perforin-like protein 4 0.0157 0.0731 0.5293
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0091 0.0108
Echinococcus multilocularis glycine receptor subunit beta 0.0045 0.0185 0.0219
Schistosoma mansoni opsin-like receptor 0.0021 0.007 0.0083
Schistosoma mansoni smdr2 0.0008 0.0006 0.0007
Loa Loa (eye worm) acetyltransferase 0.0058 0.025 0.0259
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0006
Leishmania major heat shock protein 83-1 0.002 0.0062 0.2364
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0017 0.005 0.1686
Giardia lamblia Grp94/Hsp90 0.0016 0.0043 0.0398
Echinococcus granulosus multidrug resistance protein 1 0.0008 0.0006 0.0007
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0011 0.0018 0.0022
Onchocerca volvulus Neuropeptide F receptor homolog 0.0021 0.007 0.0066
Brugia malayi RE15519p 0.0021 0.007 0.0072
Schistosoma mansoni amine GPCR 0.0021 0.007 0.0083
Echinococcus multilocularis somatostatin receptor 0.0021 0.007 0.0083
Loa Loa (eye worm) LGC-31 protein 0.0045 0.0185 0.0192
Loa Loa (eye worm) hypothetical protein 0.0024 0.0084 0.0087
Onchocerca volvulus 0.0024 0.0084 0.0081
Mycobacterium ulcerans hypothetical protein 0.0067 0.0294 0.2562
Trichomonas vaginalis ABC transporter, putative 0.0008 0.0006 0.0212
Echinococcus multilocularis potassium channel subfamily K 8 0.0011 0.0018 0.0022
Toxoplasma gondii heat shock protein HSP90 0.002 0.0062 0.0854
Echinococcus multilocularis neuropeptide FF receptor 2 0.0021 0.007 0.0083
Echinococcus granulosus Polycystic kidney disease protein 0.0291 0.1382 0.1638
Onchocerca volvulus 0.0021 0.007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0021 0.007 0.0083
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0067 0.0294 0.2562
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0011 0.0018 0.053
Loa Loa (eye worm) melatonin receptor type 1A 0.0021 0.007 0.0072
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0021 0.007 0.0072
Echinococcus multilocularis g-protein coupled receptor 0.0021 0.007 0.0083
Trypanosoma brucei hypothetical protein, conserved 0.001 0.0015 0.0389
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.007 0.0083
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0008 0.0006 0.0212
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.007 0.0083
Trypanosoma cruzi ion transport protein, putative 0.0011 0.0018 0.053
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0202 0.8176
Mycobacterium tuberculosis Conserved hypothetical protein 0.0032 0.0123 0.0117
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1892 0.9175 0.9175
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0011 0.0018 0.0019
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0057 0.0246 0.0292
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0085
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Echinococcus granulosus alpha 1A adrenergic receptor 0.0021 0.007 0.0083
Brugia malayi 'Paired box' domain containing protein 0.0038 0.0152 0.0157
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0011 0.0018 0.0019
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0017 0.005 0.0678
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0008 0.0006 0.0212
Trichomonas vaginalis heat shock protein, putative 0.0016 0.0043 0.1458
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.007 0.0083
Echinococcus granulosus potassium channel subfamily K 8 0.0011 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0045 0.0185 0.0192
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0011 0.0018 0.0019
Schistosoma mansoni neuropeptide receptor 0.0021 0.007 0.0083
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0021 0.007 0.0072
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0021 0.0067 0.008
Entamoeba histolytica deoxycytidyl transferase, putative 0.0032 0.0123 0.1723
Schistosoma mansoni heat shock protein 0.002 0.0062 0.0074
Brugia malayi 'Paired box' domain containing protein 0.0038 0.0152 0.0157
Schistosoma mansoni nAChR subunit 0.0045 0.0185 0.0219
Onchocerca volvulus 0.0011 0.0018 0.0013
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0045 0.0185 0.0192
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0021 0.007 0.0083
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0057 0.0246 0.0255
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0008 0.0006 0.0212
Echinococcus granulosus sex peptide receptor 0.0021 0.007 0.0083
Mycobacterium tuberculosis Probable aminotransferase 0.0067 0.0294 0.0288
Schistosoma mansoni biogenic amine receptor 0.0021 0.007 0.0083
Brugia malayi Serotonin receptor 0.0021 0.007 0.0072
Brugia malayi Heterochromatin protein 1 0.0042 0.0173 0.0179
Echinococcus multilocularis paired box protein pax 1 0.0038 0.0152 0.018
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.001 0.0013 0.006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.007
Entamoeba histolytica P-glycoprotein-1 0.0008 0.0006 0.0087
Loa Loa (eye worm) hypothetical protein 0.0045 0.0185 0.0192
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0291 0.1382 0.1431
Toxoplasma gondii heat shock protein 75, putative 0.0008 0.0006 0.0078
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0011 0.0018 0.0019
Echinococcus multilocularis nAChR subunit 0.0024 0.0084 0.01
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0019
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.011 0.0501 0.0513
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.007
Loa Loa (eye worm) hypothetical protein 0.0021 0.007 0.0072
Echinococcus granulosus geminin 0.0205 0.0962 0.1141
Schistosoma mansoni flap endonuclease-1 0.0014 0.0036 0.0043
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0021 0.007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0024 0.0084 0.0087
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.007 0.0083
Mycobacterium ulcerans DNA polymerase IV 0.0048 0.0202 0.1724
Echinococcus multilocularis ornithine aminotransferase 0.001 0.0013 0.0015
Toxoplasma gondii Hsp90 domain-containing protein 0.0008 0.0006 0.0078
Loa Loa (eye worm) hypothetical protein 0.0024 0.0084 0.0087
Entamoeba histolytica P-glycoprotein-2, putative 0.0008 0.0006 0.0087
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0016 0.0043 0.0593
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0011 0.0019 0.002

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0052 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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