Detailed information for compound 154483

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 325.383 | Formula: C13H13N2O4S2-
  • H donors: 1 H acceptors: 5 LogP: 2.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]([C@@H]1C(=O)N2[C@H]1[C@H](C)C(=C2C(=O)[O-])Sc1nccs1)O
  • InChi: 1S/C13H14N2O4S2/c1-5-8-7(6(2)16)11(17)15(8)9(12(18)19)10(5)21-13-14-3-4-20-13/h3-8,16H,1-2H3,(H,18,19)/p-1/t5-,6-,7-,8-/m1/s1
  • InChiKey: ICYYFEDXLOJVIO-WCTZXXKLSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0523 0.3443 0.5793
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0045 0.0071 0.0084
Schistosoma mansoni microtubule-associated protein tau 0.0771 0.519 0.5186
Onchocerca volvulus 0.0172 0.0968 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0816 0.5506 0.927
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0823 0.0816
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0047 0.0088 0.0077
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0081 0.0122
Echinococcus granulosus FTZ F1 alpha 0.0045 0.0071 0.0071
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0045 0.0071 0.0071
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0177 0.1005 0.118
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0045 0.0071 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0088 0.0095
Plasmodium falciparum glutathione reductase 0.0136 0.0715 0.6426
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0089 0.0088
Loa Loa (eye worm) phosphatidylinositol 3 0.0877 0.5939 0.6627
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0047 0.0088 0.0369
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0192 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0615 0.4091 0.6885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0554 0.0921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0523 0.3443 0.5793
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0186 0.1068 0.1786
Brugia malayi Bromodomain containing protein 0.0041 0.0046 0.0055
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0186 0.1068 0.1261
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0186 0.1068 0.1184
Schistosoma mansoni hypothetical protein 0.0358 0.2281 0.2275
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0589 0.3908 0.6575
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0045 0.0071 0.0084
Brugia malayi glutathione reductase 0.0136 0.0715 0.0844
Echinococcus multilocularis FTZ F1 alpha 0.0045 0.0071 0.0071
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0047 0.0088 0.0135
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0877 0.5939 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0615 0.4088 0.6879
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.041 0.2645 0.2645
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0113 0.0554 0.0921
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1005 0.1682
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0135 0.016
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0113 0.0554 0.0646
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0045 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0358 0.2281 0.2275
Trypanosoma cruzi trypanothione reductase, putative 0.0136 0.0715 0.0836
Loa Loa (eye worm) hypothetical protein 0.0157 0.0864 0.0957
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0186 0.1068 0.1787
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0008 0.0008
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0113 0.0554 0.4796
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0291 0.1803 0.1797
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0047 0.0088 0.0467
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0291 0.1803 0.2123
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0045 0.0071 0.0071
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0008 0.0009
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.1365 0.6229
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0877 0.5939 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0816 0.5506 0.927
Giardia lamblia Hypothetical protein 0.0113 0.0554 0.0808
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0173 0.0976 0.0969
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0186 0.1068 0.1067
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0816 0.5506 0.927
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0113 0.0554 0.0921
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0113 0.0554 0.092
Plasmodium falciparum thioredoxin reductase 0.0136 0.0715 0.6426
Schistosoma mansoni steroid hormone receptor ad4bp 0.0045 0.0071 0.0064
Loa Loa (eye worm) hypothetical protein 0.0047 0.0089 0.0091
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0044 0.0063 0.0061
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0113 0.0554 0.5153
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0208 0.1222 0.1221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0229 0.1372 0.2301
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.0322 0.0321
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0113 0.0554 0.0646
Loa Loa (eye worm) thioredoxin reductase 0.0136 0.0715 0.079
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0047 0.0088 0.0088
Brugia malayi steroid hormone receptor 0.0045 0.0071 0.0084
Mycobacterium tuberculosis Probable oxidoreductase 0.0345 0.2187 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.3269 0.5499
Onchocerca volvulus Protein ultraspiracle homolog 0.0045 0.0071 0.0661
Plasmodium falciparum thioredoxin reductase 0.0047 0.0088 0.0077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0071 0.0071
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0589 0.3908 0.6575
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0089 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.491 0.8265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0045 0.0071 0.0071
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.1068 0.1068
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0192 0.0191
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0186 0.1068 0.1787
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0186 0.1068 0.2162
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0877 0.5939 0.7014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0761 0.5117 0.8614
Loa Loa (eye worm) hypothetical protein 0.008 0.0322 0.0351
Loa Loa (eye worm) hypothetical protein 0.0145 0.0777 0.0859
Trichomonas vaginalis bromodomain-containing protein, putative 0.0053 0.0126 0.02
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0135 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0656 0.4378 0.7368
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0816 0.5506 0.6501
Loa Loa (eye worm) hypothetical protein 0.0561 0.3708 0.4134
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0047 0.0088 0.0467
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0053 0.0126 0.1117
Echinococcus multilocularis expressed protein 0.0425 0.2751 0.2751
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0291 0.1803 0.1803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0045 0.0071 0.0071
Giardia lamblia Fructose-bisphosphate aldolase 0.0573 0.3791 0.6334
Echinococcus granulosus muscleblind protein 0.0145 0.0777 0.0776
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0334 0.211 0.3544
Plasmodium vivax hypothetical protein 0.0113 0.0554 0.5153
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0071 0.0084
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0334 0.211 0.3544
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0071
Onchocerca volvulus 0.0113 0.0554 0.5684
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0656 0.4378 0.7368
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.1068 0.1068
Giardia lamblia Phosphatidylinositol 4-kinase 0.0113 0.0554 0.0808
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0761 0.5117 0.8614
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.031 0.1943 0.888
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0186 0.1068 0.1061
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Loa Loa (eye worm) hypothetical protein 0.0255 0.1554 0.1727
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0047 0.0088 0.0095
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0071
Leishmania major hypothetical protein, conserved 0.0218 0.1295 0.2171
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1236 0.8464 0.8464
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.202 0.3393
Entamoeba histolytica protein kinase rad3, putative 0.0291 0.1803 0.3027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.491 0.8265
Schistosoma mansoni fkbp-rapamycin associated protein 0.0291 0.1803 0.1797
Brugia malayi nuclear hormone receptor 0.0045 0.0071 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0877 0.5939 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0113 0.0554 0.0546
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0334 0.211 0.2104
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0113 0.0554 0.1114
Plasmodium falciparum glutathione reductase 0.0047 0.0088 0.0077
Brugia malayi beta-lactamase family protein 0.0036 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0076
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0113 0.0554 0.0553
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0088 0.0095
Loa Loa (eye worm) phosphatidylinositol 3 0.1306 0.8958 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0045 0.0071 0.0071
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0045 0.0071 0.0064
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0113 0.0554 0.0921
Schistosoma mansoni thyroid hormone receptor 0.0045 0.0071 0.0064
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0047 0.0088 0.0135
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0008 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0334 0.211 0.3544
Entamoeba histolytica hypothetical protein 0.0668 0.4463 0.7512
Brugia malayi Steroid receptor seven-up type 2 0.0045 0.0071 0.0084
Schistosoma mansoni hypothetical protein 0.0113 0.0554 0.0546
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0554 0.0921
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1236 0.8464 0.8463
Echinococcus multilocularis microtubule associated protein 2 0.0771 0.519 0.519
Loa Loa (eye worm) cytochrome P450 family protein 0.0084 0.0347 0.0379
Loa Loa (eye worm) hypothetical protein 0.0116 0.0574 0.0633
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.0823 0.0823
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0208 0.1222 0.1221
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0291 0.1803 0.2131
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0045 0.0071 0.0084
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0656 0.4378 0.7368
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0047 0.0088 0.0135
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0113 0.0554 0.5153
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0291 0.1803 0.1803
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0071 0.0071
Loa Loa (eye worm) acetyltransferase 0.0173 0.0976 0.1082
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0008 0.0007
Trypanosoma brucei trypanothione reductase 0.0136 0.0715 0.1192
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0703 0.4708 0.7924
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0334 0.211 0.2486
Echinococcus granulosus serine protein kinase ATM 0.0291 0.1803 0.1803
Loa Loa (eye worm) phosphatidylinositol 3 0.0113 0.0554 0.061
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0045 0.0071 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.491 0.8265
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0113 0.0554 0.0546
Trichomonas vaginalis PIKK family atypical protein kinase 0.0615 0.4091 0.6885
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0877 0.5939 0.5938
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0261 0.1596 0.2587
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0151 0.0823 0.0972
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0089 0.0845
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0668 0.4463 0.7512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0761 0.5117 0.8614
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0321 0.202 0.4105
Loa Loa (eye worm) hypothetical protein 0.0321 0.202 0.2248
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0877 0.5939 1
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0071 0.0064
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0047 0.0088 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0045 0.0071 0.0071
Onchocerca volvulus 0.0045 0.0071 0.0661
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0345 0.2187 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0047 0.0088 0.0135
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.0322 0.0314
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0045 0.0071 0.0064
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0071
Echinococcus multilocularis 0.0113 0.0554 0.0553
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1454 1 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.0322 0.038
Loa Loa (eye worm) hypothetical protein 0.0157 0.0864 0.0957
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.0696 0.0769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0291 0.1803 0.3027
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0113 0.0554 0.5153
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0047 0.0088 0.0088
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0047 0.0088 0.0077
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0877 0.5939 0.7014
Loa Loa (eye worm) phosphatidylinositol kinase 0.0113 0.0554 0.061
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0186 0.1068 0.2162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0823 0.0816
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0045 0.0071 0.0071
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.0322 0.0321
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0113 0.0554 0.0646
Brugia malayi acetyltransferase, GNAT family protein 0.0173 0.0976 0.1154
Entamoeba histolytica hypothetical protein 0.0291 0.1803 0.3027
Echinococcus multilocularis thioredoxin glutathione reductase 0.0137 0.0719 0.0718
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0346 0.2194 0.3686
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0186 0.1068 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0561 0.3708 0.3707
Echinococcus multilocularis Zinc finger, PHD finger 0.0186 0.1068 0.1067
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0877 0.5939 0.5935
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0877 0.5939 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0137 0.0719 0.0718
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0186 0.1068 0.1061
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0045 0.0071 0.0064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0561 0.3708 0.4381
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0047 0.0088 0.008
Mycobacterium tuberculosis Conserved hypothetical protein 0.0113 0.0554 0.2506
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0113 0.0554 0.1114
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0071
Onchocerca volvulus Bile acid receptor homolog 0.0045 0.0071 0.0661
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0816 0.5506 0.927
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0045 0.0071 0.0064
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0047 0.0088 0.0104
Brugia malayi hypothetical protein 0.0172 0.0968 0.1144
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0186 0.1068 0.1067
Leishmania major phosphatidylinositol 4-kinase, putative 0.0113 0.0554 0.0921
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0334 0.211 0.3544
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0088 0.0095
Loa Loa (eye worm) hypothetical protein 0.0037 0.0017 0.001
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0334 0.211 0.3544
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.028 0.1727 0.7888
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0045 0.0071 0.0071
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0008 0.0001
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0877 0.5939 1
Leishmania major hypothetical protein, unknown function 0.0113 0.0554 0.0921
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1236 0.8464 0.8464
Onchocerca volvulus 0.0047 0.0089 0.0845
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0047 0.0088 0.5
Brugia malayi Muscleblind-like protein 0.0145 0.0777 0.0917
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0135 0.0127
Loa Loa (eye worm) MBCTL1 0.0054 0.0135 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0045 0.0071 0.0084
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0071
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0113 0.0554 0.0921
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0777 0.0776
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0135 0.0135
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0045 0.0071 0.0071
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0877 0.5939 0.5938
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0008 0.0001
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0088 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.3269 0.5499
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0186 0.1068 0.1786
Brugia malayi beta-lactamase 0.0036 0.0008 0.0009
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0047 0.0088 1
Schistosoma mansoni retinoic acid receptor RXR 0.0045 0.0071 0.0064
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0054 0.0135 0.0142
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0008 0.0001
Loa Loa (eye worm) hypothetical protein 0.0208 0.1222 0.1357
Mycobacterium tuberculosis Probable reductase 0.031 0.1943 0.888
Giardia lamblia GTOR 0.0877 0.5939 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.031 0.1943 0.888
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.491 0.8265
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0561 0.3708 0.3707
Echinococcus granulosus microtubule associated protein 2 0.0771 0.519 0.519
Loa Loa (eye worm) phosphatidylinositol 3 0.0221 0.1312 0.1457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.491 0.8265
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0047 0.0088 0.0135
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0047 0.0088 0.0164
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0047 0.0088 0.0135
Onchocerca volvulus 0.008 0.0322 0.327
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0089 0.0081
Brugia malayi beta-lactamase family protein 0.0036 0.0008 0.0009
Brugia malayi Cytochrome P450 family protein 0.0084 0.0347 0.041
Toxoplasma gondii thioredoxin reductase 0.0136 0.0715 0.1442
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0071
Schistosoma mansoni thyroid hormone receptor 0.0045 0.0071 0.0064
Echinococcus granulosus histone acetyltransferase KAT2B 0.0053 0.0126 0.0126
Schistosoma mansoni hypothetical protein 0.0208 0.1222 0.1215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.3269 0.5499
Brugia malayi nuclear receptor NHR-88 0.0045 0.0071 0.0084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0088 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0877 0.5939 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0113 0.0554 0.061
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0638 0.425 0.5022
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0113 0.0554 0.0646
Mycobacterium tuberculosis Putative ferredoxin reductase 0.031 0.1943 0.888
Mycobacterium tuberculosis Probable dehydrogenase 0.031 0.1943 0.888
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0045 0.0071 0.0084
Schistosoma mansoni coup transcription factor 0.0045 0.0071 0.0064
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1454 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0113 0.0554 0.0553
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0008 0.0001
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0113 0.0554 0.0553
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0291 0.1803 0.2131
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0186 0.1068 0.1787
Toxoplasma gondii target of rapamycin (TOR), putative 0.0731 0.491 1
Echinococcus multilocularis serine protein kinase ATM 0.0291 0.1803 0.1803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0645 0.4298 0.7234
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0554 0.5153
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0008 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1236 0.8464 1
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.1222 0.2047
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0113 0.0554 0.0546
Loa Loa (eye worm) hypothetical protein 0.0113 0.0554 0.061
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0448 0.2912 0.4896
Brugia malayi ecdysteroid receptor 0.0045 0.0071 0.0084
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0047 0.0088 0.0135
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0089 0.0081
Loa Loa (eye worm) hypothetical protein 0.0068 0.0237 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0615 0.4088 0.6879
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0186 0.1068 0.1787
Echinococcus granulosus ecdysone induced protein 78C 0.0045 0.0071 0.0071
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0186 0.1068 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.1005 0.1682
Treponema pallidum fructose-bisphosphate aldolase 0.0573 0.3791 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0045 0.0071 0.0071
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0053 0.0126 0.0241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.0823 0.0816
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0291 0.1803 0.3027
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0113 0.0554 0.0553
Brugia malayi Inositol-1 0.0036 0.0008 0.001
Toxoplasma gondii NADPH-glutathione reductase 0.0047 0.0088 0.0164
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0071 0.0071
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0071 0.0084
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0113 0.0554 0.0654
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0045 0.0071 0.0661
Echinococcus multilocularis muscleblind protein 0.0145 0.0777 0.0776
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0071 0.0064
Brugia malayi mbt repeat family protein 0.0047 0.0089 0.0105
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0008 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.0823 0.0823
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0413 0.2666 0.4481
Loa Loa (eye worm) hypothetical protein 0.0177 0.1005 0.1115
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0088 0.0095
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0047 0.0088 0.0095
Loa Loa (eye worm) hypothetical protein 0.0172 0.0968 0.1073
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0047 0.0088 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0553 0.3651 0.6143
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0877 0.5939 0.7016
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0291 0.1803 0.2123
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0045 0.0071 0.0084
Schistosoma mansoni bromodomain containing protein 0.0065 0.0216 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0583 0.3868 0.6508
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0761 0.512 0.862
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0816 0.5506 0.6501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.2912 0.4896
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0045 0.0071 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0045 0.0071 0.0071
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.028 0.1727 1
Echinococcus granulosus geminin 0.0358 0.2281 0.2281
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0053 0.0126 0.0241
Brugia malayi FAT domain containing protein 0.0208 0.1222 0.1444
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1236 0.8464 1
Loa Loa (eye worm) hypothetical protein 0.0291 0.1803 0.2006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0045 0.0071 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0291 0.1803 0.3027
Loa Loa (eye worm) phosphatidylinositol 3 0.0656 0.4378 0.4882
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0877 0.5939 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0071 0.0084
Toxoplasma gondii FATC domain-containing protein 0.0291 0.1803 0.3663
Schistosoma mansoni hypothetical protein 0.0287 0.1781 0.1774
Brugia malayi mbt repeat family protein 0.0047 0.0089 0.0105
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0186 0.1068 0.1253
Plasmodium vivax glutathione reductase, putative 0.0136 0.0715 0.6671
Trichomonas vaginalis glutathione reductase, putative 0.0047 0.0088 0.0135
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0089 0.0088
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.031 0.1943 0.888
Entamoeba histolytica hypothetical protein 0.0113 0.0554 0.092
Schistosoma mansoni RAR-like nuclear receptor 0.0045 0.0071 0.0064
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0071 0.0071
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0089 0.0091
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0071
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0071 0.0084
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0045 0.0071 0.0071
Onchocerca volvulus 0.0113 0.0554 0.5684
Entamoeba histolytica hypothetical protein 0.0113 0.0554 0.092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0615 0.4091 0.6885
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0438 0.2842 0.4778
Leishmania major phosphatidylinositol kinase, putative 0.0113 0.0554 0.0921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0499 0.3269 0.5499
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0113 0.0554 0.4796
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.0823 0.0823
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0345 0.2187 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0113 0.0554 0.061
Trichomonas vaginalis mercuric reductase, putative 0.0047 0.0088 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0615 0.4091 0.6885
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0045 0.0071 0.0071
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0761 0.512 0.862
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0047 0.0088 0.0758
Loa Loa (eye worm) hypothetical protein 0.0145 0.0777 0.0859
Loa Loa (eye worm) inositol-1 0.0036 0.0008 0.0001
Leishmania major phosphatidylinositol kinase related protein, putative 0.0113 0.0554 0.0921
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0186 0.1068 0.1067
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0113 0.0554 0.0654
Leishmania major phosphatidylinositol 3-kinase, putative 0.0499 0.3269 0.5499
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0045 0.0071 0.0084
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0045 0.0071 0.0071
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0497 0.0579
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0008 0.0003
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1236 0.8464 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0047 0.0088 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Leishmania major trypanothione reductase 0.0136 0.0715 0.1192
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0186 0.1068 0.1253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0669 0.4473 0.7528
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0053 0.0126 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.491 0.8265
Loa Loa (eye worm) glutathione reductase 0.0136 0.0715 0.079
Brugia malayi photoreceptor-specific nuclear receptor 0.0045 0.0071 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0645 0.4298 0.7234
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0113 0.0554 0.0646
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0113 0.0554 0.1114
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0113 0.0554 0.0654
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0008 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.0696 0.0769
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0221 0.1312 0.1542
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0334 0.211 0.3544
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0151 0.0823 0.0911
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0045 0.0071 0.0084
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0135 0.0135
Loa Loa (eye worm) phosphatidylinositol 3 0.0113 0.0554 0.061
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0088 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0615 0.4088 0.6879
Trichomonas vaginalis PIKK family atypical protein kinase 0.0761 0.5117 0.8614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0523 0.3443 0.5793
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0089 0.0088
Echinococcus multilocularis ecdysone induced protein 78C 0.0045 0.0071 0.0071
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0499 0.3269 0.5499
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.028 0.1727 0.7888
Entamoeba histolytica hypothetical protein 0.0113 0.0554 0.092
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0047 0.0088 0.0467
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0089 0.0088
Echinococcus multilocularis geminin 0.0358 0.2281 0.2281
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.031 0.1943 0.888
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0186 0.1068 0.1787
Trypanosoma cruzi target of rapamycin kinase 3 0.0761 0.512 0.6046
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0136 0.0715 0.3244
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.0823 0.0823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.491 0.8265
Plasmodium vivax thioredoxin reductase, putative 0.0136 0.0715 0.6671
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0441 0.2865 0.4754
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0345 0.2187 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0573 0.3791 0.6378
Echinococcus granulosus expressed protein 0.0425 0.2751 0.2751
Trichomonas vaginalis PIKK family atypical protein kinase 0.0761 0.5117 0.8614
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0047 0.0088 0.0758
Trichomonas vaginalis PIKK family atypical protein kinase 0.0877 0.5939 1
Brugia malayi Bromodomain containing protein 0.0077 0.0296 0.035
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0816 0.5506 0.6505
Echinococcus granulosus histone acetyltransferase KAT2B 0.0166 0.0926 0.0926
Brugia malayi MH2 domain containing protein 0.0133 0.0696 0.0822
Leishmania major phosphatidylinositol 3-kinase, putative 0.0186 0.1068 0.1787
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0008 0.0001
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.041 0.2645 0.2645
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0113 0.0554 0.0553
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0334 0.211 0.2493
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0045 0.0071 0.0064
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0173 0.0976 0.0976
Brugia malayi Thioredoxin reductase 0.0136 0.0715 0.0844
Loa Loa (eye worm) steroid hormone receptor 0.0045 0.0071 0.0071
Mycobacterium leprae conserved hypothetical protein 0.0113 0.0554 0.2506

Activities

Activity type Activity value Assay description Source Reference
Binding (binding) = 69 % Binding affinity towards Human Serum albumin. ChEMBL. No reference
MIC (functional) = 0.025 ug ml-1 In vitro minimum inhibitory concentration of the compound against Staphylococcus aureus 209p ChEMBL. No reference
MIC (functional) = 0.025 ug ml-1 In vitro minimum inhibitory concentration of the compound against Staphylococcus pyogenes COOK ChEMBL. No reference
MIC (functional) = 0.05 ug ml-1 In vitro minimum inhibitory concentration of the compound against Klebsiella pneumoniae ATCC 10031 ChEMBL. No reference
MIC (functional) = 0.1 ug ml-1 In vitro minimum inhibitory concentration of the compound against Staphylococcus epidermidis IAM1296 ChEMBL. No reference
MIC (functional) = 0.78 ug ml-1 In vitro minimum inhibitory concentration of the compound against Staphylococcus aureus MS9408 ChEMBL. No reference
MIC (functional) = 0.78 ug ml-1 In vitro minimum inhibitory concentration of the compound against Escherichia coli NIHJ JC-2 ChEMBL. No reference
MIC (functional) = 12.5 ug ml-1 In vitro minimum inhibitory concentration of the compound against Staphylococcus aureus SP-7928 ChEMBL. No reference
Time (binding) = 15 min Time of enzyme-catalyzed hydrolysis from 500 uM to 400 uM in the presence of purified renal DHP-1 of swine ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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