Detailed information for compound 1549480

Basic information

Technical information
  • TDR Targets ID: 1549480
  • Name: 2-[4-bromo-5-methyl-3-(trifluoromethyl)pyrazo l-1-yl]-N-cyclohexyl-N-methylacetamide
  • MW: 382.219 | Formula: C14H19BrF3N3O
  • H donors: 0 H acceptors: 2 LogP: 3.68 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(C1CCCCC1)C)Cn1nc(c(c1C)Br)C(F)(F)F
  • InChi: 1S/C14H19BrF3N3O/c1-9-12(15)13(14(16,17)18)19-21(9)8-11(22)20(2)10-6-4-3-5-7-10/h10H,3-8H2,1-2H3
  • InChiKey: OFWCDNFOZQINNL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-bromo-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-N-cyclohexyl-N-methyl-acetamide
  • 2-[4-bromo-5-methyl-3-(trifluoromethyl)-1-pyrazolyl]-N-cyclohexyl-N-methylacetamide
  • 2-[4-bromo-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-N-cyclohexyl-N-methyl-ethanamide
  • BAS 00414867
  • AG-690/10497062
  • STK342464
  • ZINC00826498

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Polycystic kidney disease protein 0.0501 0.1714 0.1714
Echinococcus multilocularis macrophage expressed protein 0.2175 0.7511 0.7511
Trichomonas vaginalis ABC transporter, putative 0.0014 0.0027 0.2144
Trypanosoma cruzi heat shock protein 90, putative 0.0009 0.0009 0.0723
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1394 0.4807 0.9172
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0048 0.0147 0.2275
Plasmodium falciparum multidrug resistance protein 1 0.0014 0.0027 0.0158
Toxoplasma gondii MAC/Perforin domain-containing protein 0.024 0.0812 1
Echinococcus granulosus endoplasmin 0.0012 0.002 0.002
Trypanosoma brucei heat shock protein 90, putative 0.0015 0.003 0.2364
Schistosoma mansoni heat shock protein 0.0015 0.003 0.003
Echinococcus granulosus lipoxygenase domain containing protein 0.0501 0.1714 0.1714
Trypanosoma cruzi heat shock protein 85, putative 0.0012 0.002 0.1549
Plasmodium vivax multidomain scavenger receptor, putative 0.0501 0.1714 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0012 0.002 0.1549
Entamoeba histolytica HEAT repeat domain containing protein 0.0007 0.0002 0.017
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0007 0.0002 0.017
Echinococcus multilocularis importin 5 0.0007 0.0002 0.0002
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0012 0.002 0.0243
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0014 0.0027 0.0027
Trypanosoma brucei unspecified product 0.0016 0.0036 0.2869
Entamoeba histolytica P-glycoprotein-2 0.0014 0.0027 0.2144
Schistosoma mansoni hypothetical protein 0.2175 0.7511 0.7511
Trypanosoma cruzi DNA repair protein, putative 0.0015 0.0031 0.2453
Trypanosoma brucei DNA polymerase eta, putative 0.0035 0.0101 0.8039
Echinococcus multilocularis flap endonuclease 1 0.0012 0.002 0.002
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0027 0.0027
Echinococcus granulosus dna polymerase eta 0.0035 0.0101 0.0101
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0014 0.0027 0.0027
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0014 0.0027 0.0027
Echinococcus multilocularis translational activator gcn1 0.0007 0.0002 0.0002
Loa Loa (eye worm) flap endonuclease-1 0.0012 0.002 0.0115
Chlamydia trachomatis hypothetical protein 0.024 0.0812 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0068 0.522
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0173 0.0579 1
Chlamydia trachomatis recombinase RecA 0.0048 0.0147 0.1526
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0126 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0068 0.5405
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0077 0.6123
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0014 0.0027 0.0027
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0068 0.0068
Schistosoma mansoni multidrug resistance protein 0.0014 0.0027 0.0027
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Trypanosoma cruzi DNA polymerase kappa, putative 0.0036 0.0103 0.8176
Brugia malayi Phospholipase A2 family protein 0.0122 0.0401 0.2337
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.004 0.3172
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0046 0.3666
Onchocerca volvulus 0.0501 0.1714 1
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0005 0.0389
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.001 0.0015 0.0186
Loa Loa (eye worm) hypothetical protein 0.0081 0.026 0.1514
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0027 0.2144
Entamoeba histolytica P-glyco protein 6, putative 0.0014 0.0027 0.2144
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0233
Entamoeba histolytica Flap nuclease, putative 0.0012 0.002 0.1568
Onchocerca volvulus 0.0014 0.0027 0.0158
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0027 0.2144
Echinococcus multilocularis lipoxygenase domain containing protein 0.0501 0.1714 0.1714
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0068 0.0068
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0014 0.0027 0.2144
Brugia malayi Heterochromatin protein 1 0.0031 0.0087 0.051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0269
Echinococcus granulosus RUN 0.0501 0.1714 0.1714
Schistosoma mansoni endoplasmin 0.0015 0.003 0.003
Schistosoma mansoni Replicative DNA helicase 0.0173 0.0579 0.0579
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0046 0.3666
Onchocerca volvulus Deterin homolog 0.0098 0.0318 0.1858
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0012 0.002 0.1568
Plasmodium vivax perforin-like protein 2 0.024 0.0812 0.4739
Schistosoma mansoni hypothetical protein 0.0014 0.0027 0.0027
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0019 0.0045 0.026
Trypanosoma brucei heat shock protein, putative 0.0015 0.003 0.2364
Toxoplasma gondii heat shock protein 90, putative 0.0015 0.003 0.0367
Toxoplasma gondii heat shock protein HSP90 0.0015 0.003 0.0367
Schistosoma mansoni hypothetical protein 0.0372 0.1267 0.1267
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0103 0.8176
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0027 0.2144
Echinococcus multilocularis snurportin 1 0.0372 0.1267 0.1267
Schistosoma mansoni hypothetical protein 0.0205 0.0688 0.0688
Leishmania major DNA polymerase kappa, putative 0.0007 0.0005 0.0389
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0062 0.0081
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0068 0.0397
Trichomonas vaginalis CAMK family protein kinase 0.0021 0.0052 0.4121
Plasmodium falciparum transportin 0.0007 0.0002 0.0012
Onchocerca volvulus 0.0014 0.0027 0.0157
Schistosoma mansoni kinase 0.0022 0.0054 0.0054
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0068 0.5405
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.01 0.7933
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1267 0.7391
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0027 0.2144
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.1519 0.5239 1
Echinococcus granulosus importin 5 0.0007 0.0002 0.0002
Leishmania major importin beta-1 subunit, putative 0.0028 0.0077 0.6123
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0042 0.0126 1
Trichomonas vaginalis heat shock protein, putative 0.0015 0.003 0.2364
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0027 0.2144
Trypanosoma cruzi polo-like protein kinase, putative 0.0042 0.0126 1
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Entamoeba histolytica P-glycoprotein 5, putative 0.0014 0.0027 0.2144
Trypanosoma brucei heat shock protein, putative 0.0015 0.003 0.2364
Schistosoma mansoni hypothetical protein 0.0205 0.0688 0.0688
Toxoplasma gondii HEAT repeat-containing protein 0.0007 0.0002 0.0026
Entamoeba histolytica Ran family GTPase 0.0026 0.0068 0.5405
Trypanosoma brucei DNA polymerase IV, putative 0.0033 0.0093 0.7363
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0027 0.2144
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0085 0.6729
Giardia lamblia Heat shock protein HSP 90-alpha 0.0015 0.003 0.2056
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0173 0.0579 0.3238
Loa Loa (eye worm) hypothetical protein 0.0098 0.0318 0.1858
Schistosoma mansoni importin-beta 2 0.0007 0.0002 0.0002
Trichomonas vaginalis heat shock protein, putative 0.0012 0.002 0.1549
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0098 0.0318 0.0318
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0014 0.0027 0.0027
Echinococcus granulosus geminin 0.0205 0.0688 0.0688
Entamoeba histolytica heat shock protein 90, putative 0.0015 0.003 0.2364
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0103 0.8176
Loa Loa (eye worm) twinkle helicase 0.0049 0.0151 0.0879
Entamoeba histolytica P-glycoprotein-2, putative 0.0014 0.0027 0.2144
Trypanosoma brucei heat shock protein, putative 0.0015 0.003 0.2364
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0098 0.0318 0.0318
Leishmania major GTP-binding protein, putative 0.0026 0.0068 0.5405
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0027 0.2144
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0103 0.8176
Entamoeba histolytica heat shock protein 90, putative 0.0015 0.003 0.2364
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0027 0.2144
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0027 0.0072 0.01
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0013 0.0013
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0027 0.2144
Entamoeba histolytica P-glycoprotein-5 0.0014 0.0027 0.2144
Plasmodium falciparum perforin-like protein 3 0.024 0.0812 0.4739
Plasmodium vivax transportin, putative 0.0007 0.0002 0.0012
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0048 0.0147 0.0737
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0027 0.2144
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0126 1
Echinococcus multilocularis heat shock protein 90 0.0015 0.003 0.003
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0027 0.0027
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.2894 1 1
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0015 0.0031 0.2453
Trypanosoma brucei chrX additional, unordered contigs 0.0007 0.0005 0.0389
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0068 0.0397
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Echinococcus granulosus heat shock protein 90 0.0015 0.003 0.003
Giardia lamblia Kinase, PLK 0.0042 0.0126 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0042 0.0126 1
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0014 0.0027 0.0158
Entamoeba histolytica hypothetical protein 0.0028 0.0077 0.6123
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0027 0.2144
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0126 1
Trypanosoma brucei heat shock protein, putative 0.0015 0.003 0.2364
Giardia lamblia Heat shock protein HSP 90-alpha 0.0012 0.002 0.1207
Trichomonas vaginalis hypothetical protein 0.0007 0.0002 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.004 0.3172
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.01 0.123
Trypanosoma cruzi polo-like protein kinase, putative 0.0042 0.0126 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0027 0.0027
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0005 0.0389
Trypanosoma cruzi heat shock protein 85, putative 0.0015 0.003 0.2364
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0103 0.8176
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0027 0.2144
Onchocerca volvulus 0.0098 0.0318 0.1858
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0085 0.0494
Trichomonas vaginalis DNA polymerase eta, putative 0.0036 0.0103 0.8176
Onchocerca volvulus Serine\/threonine kinase homolog 0.0042 0.0126 0.0735
Echinococcus multilocularis chromobox protein 1 0.0031 0.0087 0.0087
Mycobacterium ulcerans heat shock protein 90 0.0012 0.002 0.0254
Schistosoma mansoni ran 0.0026 0.0068 0.0068
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0173 0.0579 1
Loa Loa (eye worm) hypothetical protein 0.035 0.119 0.6945
Echinococcus multilocularis lipoxygenase domain containing protein 0.0501 0.1714 0.1714
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0044 0.0547
Echinococcus granulosus importin subunit beta 1 0.0035 0.01 0.01
Loa Loa (eye worm) doublecortin family protein 0.0501 0.1714 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0024 0.0062 0.0062
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0103 0.8176
Trichomonas vaginalis heat shock protein, putative 0.0012 0.002 0.1549
Brugia malayi ABC transporter family protein 0.0014 0.0027 0.0158
Loa Loa (eye worm) multidrug resistance protein 3 0.0014 0.0027 0.0158
Echinococcus multilocularis multidrug resistance protein 1 0.0014 0.0027 0.0027
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0036 0.0103 0.8176
Schistosoma mansoni smdr2 0.0014 0.0027 0.0027
Trichomonas vaginalis abcb9, putative 0.0014 0.0027 0.2144
Trypanosoma brucei unspecified product 0.0016 0.0036 0.2869
Plasmodium falciparum perforin-like protein 2 0.024 0.0812 0.4739
Plasmodium falciparum perforin-like protein 1 0.024 0.0812 0.4739
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0046 0.3682
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0024 0.0062 0.0062
Trypanosoma brucei polo-like protein kinase 0.0042 0.0126 1
Schistosoma mansoni inhibitor of apoptosis protein 0.0098 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0158
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0007 0.0003 0.0207
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0126 1
Loa Loa (eye worm) heat shock protein 90 0.0015 0.003 0.0174
Trichomonas vaginalis ran, putative 0.0026 0.0068 0.5405
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0022 0.1766
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0085 0.6729
Trypanosoma cruzi DNA polymerase kappa, putative 0.0036 0.0103 0.8176
Echinococcus multilocularis ATP binding cassette sub family B 0.0014 0.0026 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0103 0.8176
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0494
Schistosoma mansoni DNA polymerase eta 0.0035 0.0101 0.0101
Brugia malayi heat shock protein 90 0.0015 0.003 0.0174
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Echinococcus granulosus Polycystic kidney disease protein 0.0501 0.1714 0.1714
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0098 0.0318 0.1858
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0012 0.002 0.1568
Brugia malayi chromobox protein homolog 3 0.0018 0.004 0.0233
Schistosoma mansoni importin beta-1 0.0035 0.01 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0005 0.0389
Echinococcus granulosus chromobox protein 1 0.0031 0.0087 0.0087
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0042 0.0126 0.0126
Brugia malayi Endoplasmin precursor 0.0015 0.003 0.0174
Plasmodium vivax multidrug resistance protein 1, putative 0.0014 0.0027 0.0158
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0018 0.004 0.0233
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0014 0.0027 0.2144
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0072 0.5712
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0103 0.8176
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0077 0.6123
Schistosoma mansoni rab6-interacting 0.0501 0.1714 0.1714
Schistosoma mansoni multidrug resistance protein 0.0014 0.0027 0.0027
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Brugia malayi hypothetical protein 0.0501 0.1714 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0027 0.2144
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0126 1
Leishmania major DNA polymerase eta, putative 0.0035 0.0101 0.8039
Trypanosoma cruzi heat shock protein 90, putative 0.0015 0.003 0.2364
Trichomonas vaginalis chromobox protein, putative 0.0019 0.0045 0.3537
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0027 0.2144
Loa Loa (eye worm) heterochromatin protein 1 0.0031 0.0087 0.051
Echinococcus multilocularis heat shock protein 0.0015 0.003 0.003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0036 0.0103 0.8176
Trypanosoma cruzi heat shock protein 85, putative 0.0015 0.003 0.2364
Schistosoma mansoni rab6-interacting 0.0501 0.1714 0.1714
Schistosoma mansoni ran 0.0026 0.0068 0.0068
Giardia lamblia DINP protein human, muc B family 0.0027 0.0072 0.5539
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0042 0.0126 0.0735
Brugia malayi Doublecortin family protein 0.0501 0.1714 1
Schistosoma mansoni endoplasmin 0.0015 0.003 0.003
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.01 0.7933
Brugia malayi RNA, U transporter 1 0.0099 0.0322 0.188
Plasmodium vivax endoplasmin, putative 0.0015 0.003 0.0174
Schistosoma mansoni polycystin 1-related 0.0501 0.1714 0.1714
Echinococcus granulosus heat shock protein 90 0.0012 0.002 0.002
Trypanosoma brucei unspecified product 0.0033 0.0093 0.7363
Loa Loa (eye worm) endoplasmin 0.0015 0.003 0.0174
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0012 0.002 0.1568
Trichomonas vaginalis CAMK family protein kinase 0.0021 0.0052 0.4121
Mycobacterium ulcerans recombinase A 0.0048 0.0147 0.2471
Trichomonas vaginalis abcb9, putative 0.0014 0.0027 0.2144
Trypanosoma brucei heat shock protein 90, putative 0.0015 0.003 0.2364
Schistosoma mansoni hypothetical protein 0.0098 0.0318 0.0318
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0081 0.026 0.1514
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0027 0.2144
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Plasmodium falciparum importin beta, putative 0.0035 0.01 0.0583
Plasmodium falciparum LCCL domain-containing protein 0.0501 0.1714 1
Plasmodium falciparum perforin-like protein 5 0.024 0.0812 0.4739
Echinococcus granulosus snurportin 1 0.0372 0.1267 0.1267
Trichomonas vaginalis endoplasmin, putative 0.0009 0.001 0.0816
Plasmodium falciparum DNA repair protein REV1, putative 0.0007 0.0005 0.0029
Leishmania major hypothetical protein, conserved 0.0007 0.0002 0.017
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0014 0.0027 0.0332
Leishmania major hypothetical protein, conserved 0.003 0.0085 0.6729
Toxoplasma gondii HEAT repeat-containing protein 0.0007 0.0002 0.0026
Giardia lamblia Grp94/Hsp90 0.0012 0.002 0.1207
Loa Loa (eye worm) hypothetical protein 0.0035 0.01 0.0583
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0103 0.8176
Echinococcus multilocularis heat shock protein 90 0.0012 0.002 0.002
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0005 0.0389
Onchocerca volvulus Phospholipase A2 homolog 0.0122 0.0401 0.2337
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0027 0.2144
Echinococcus multilocularis transportin 1 0.0007 0.0002 0.0002
Echinococcus granulosus translational activator gcn1 0.0007 0.0002 0.0002
Plasmodium falciparum endoplasmin, putative 0.0009 0.001 0.006
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0027 0.2144
Loa Loa (eye worm) hypothetical protein 0.0035 0.0101 0.0591
Mycobacterium ulcerans DNA polymerase IV 0.0036 0.0103 0.1708
Brugia malayi hypothetical protein 0.0501 0.1714 1
Echinococcus multilocularis dna polymerase kappa 0.0036 0.0103 0.0103
Onchocerca volvulus 0.0501 0.1714 1
Plasmodium vivax perforin-like protein 4 0.024 0.0812 0.4739
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0103 0.8176
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0098 0.0318 0.0318
Trichomonas vaginalis heat shock protein, putative 0.0012 0.002 0.1549
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0126 0.0126
Echinococcus multilocularis geminin 0.0205 0.0688 0.0688
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0077 0.6123
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0024 0.0062 0.0062
Trypanosoma cruzi DNA polymerase kappa, putative 0.0036 0.0103 0.8176
Echinococcus multilocularis RUN 0.0501 0.1714 0.1714
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0085 0.0494
Trichomonas vaginalis heat shock protein, putative 0.0009 0.001 0.0816
Trichomonas vaginalis chromobox protein, putative 0.0031 0.0087 0.6945
Giardia lamblia Flap structure-specific endonuclease 0.0012 0.002 0.1227
Plasmodium vivax perforin-like protein 1 0.024 0.0812 0.4739
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0046 0.3682
Treponema pallidum recombinase A 0.0048 0.0147 0.2275
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0044 0.3528
Trypanosoma brucei heat shock protein, putative 0.0015 0.003 0.2364
Brugia malayi N-terminal motif family protein 0.0081 0.026 0.1514
Loa Loa (eye worm) hypothetical protein 0.0122 0.0401 0.2337
Schistosoma mansoni loxhd1 0.0501 0.1714 0.1714
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0014 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0501 0.1714 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.01 0.0583
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0014 0.0027 0.0014
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0027 0.0332
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0014 0.0027 0.2144
Schistosoma mansoni chromobox protein 0.0031 0.0087 0.0087
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0068 0.0397
Trichomonas vaginalis ABC transporter, putative 0.0014 0.0027 0.2144
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0014 0.0027 0.0027
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0158
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0101 0.0591
Loa Loa (eye worm) kap beta 3 protein 0.0007 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0098 0.0318 0.1858
Trypanosoma cruzi DNA damage repair protein, putative 0.0007 0.0005 0.0389
Trypanosoma cruzi Heat shock protein 83, putative 0.0015 0.003 0.2364
Brugia malayi Flap endonuclease-1 0.0012 0.002 0.0115
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0013 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0005 0.0389
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0085 0.0494
Trichomonas vaginalis ABC transporter, putative 0.0014 0.0027 0.2144
Trypanosoma cruzi DNA repair protein, putative 0.0015 0.0031 0.2453
Brugia malayi Importin beta-1 subunit 0.0035 0.01 0.0583
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Treponema pallidum replicative DNA helicase (dnaB) 0.0173 0.0579 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0022 0.1766
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0068 0.0397
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0024 0.0062 0.036
Echinococcus granulosus dna polymerase kappa 0.0036 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0501 0.1714 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0013 0.1001
Trichomonas vaginalis chromobox protein, putative 0.0031 0.0087 0.6945
Trypanosoma cruzi heat shock protein 90, putative 0.0012 0.002 0.1549
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0068 0.5405
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0027 0.2144
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0013 0.0013
Trypanosoma brucei Heat shock protein 83, putative 0.0015 0.003 0.2364
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0126 1
Plasmodium vivax heat shock protein 86, putative 0.0015 0.003 0.0174
Leishmania major DNA damage repair protein, putative 0.0007 0.0005 0.0389
Leishmania major p-glycoprotein 0.0014 0.0027 0.2144
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0098 0.0318 0.1858
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0103 0.8176
Loa Loa (eye worm) importin-beta domain-containing protein 0.0007 0.0002 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0103 0.8176
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0077 0.6123
Echinococcus multilocularis chromobox protein 1 0.0031 0.0087 0.0087
Schistosoma mansoni multidrug resistance protein 0.0014 0.0027 0.0027
Brugia malayi hypothetical protein 0.002 0.0047 0.0276
Brugia malayi ImpB/MucB/SamB family protein 0.0024 0.0062 0.036
Schistosoma mansoni lipoxygenase 0.1992 0.6878 0.6878
Echinococcus granulosus inhibitor of apoptosis protein 0.0098 0.0318 0.0318
Plasmodium vivax flap endonuclease 1, putative 0.0012 0.002 0.0115
Brugia malayi multidrug resistance protein 3 0.0014 0.0027 0.0158
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Echinococcus multilocularis dna polymerase eta 0.0035 0.0101 0.0101
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0027 0.2144
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0005 0.006
Plasmodium falciparum perforin-like protein 4 0.024 0.0812 0.4739
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0046 0.3682
Echinococcus multilocularis inhibitor of apoptosis protein 0.0098 0.0318 0.0318
Trichomonas vaginalis ABC transporter, putative 0.0014 0.0027 0.2144
Entamoeba histolytica deoxycytidyl transferase, putative 0.0024 0.0062 0.4899
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0027 0.0072 0.5712
Plasmodium vivax perforin-like protein 3 0.024 0.0812 0.4739
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0126 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0007 0.0005 0.0389
Brugia malayi hypothetical protein 0.003 0.0085 0.0494
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0101 0.8039
Echinococcus granulosus macrophage expressed protein 0.2175 0.7511 0.7511
Schistosoma mansoni terminal deoxycytidyl transferase 0.0024 0.0062 0.0062
Plasmodium vivax DNA repair protein REV1, putative 0.0007 0.0005 0.0029
Plasmodium vivax perforin-like protein 5 0.024 0.0812 0.4739
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0012 0.002 0.002
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0027 0.0027
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0085 0.1043
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0085 0.6729
Brugia malayi kap beta 3 protein 0.0007 0.0002 0.0012
Plasmodium falciparum flap endonuclease 1 0.0012 0.002 0.0115
Trypanosoma brucei heat shock protein, putative 0.0015 0.003 0.2364
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0005 0.0005
Schistosoma mansoni heat shock protein 0.0015 0.003 0.003
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Echinococcus multilocularis importin subunit beta 1 0.0035 0.01 0.01
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0014 0.0027 0.0027
Echinococcus multilocularis multidrug resistance protein 1 0.0014 0.0027 0.0027
Echinococcus multilocularis endoplasmin 0.0012 0.002 0.002
Chlamydia trachomatis replicative DNA helicase 0.0173 0.0579 0.7033
Plasmodium falciparum heat shock protein 90 0.0015 0.003 0.0174
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0014 0.0027 0.0027
Brugia malayi polk-prov protein 0.0019 0.0046 0.0269
Entamoeba histolytica P-glycoprotein-2 0.0014 0.0027 0.2144
Trypanosoma cruzi heat shock protein 85, putative 0.0015 0.003 0.2364
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0005 0.0389
Leishmania major DNA polymerase eta, putative 0.0019 0.0044 0.3528
Trypanosoma brucei heat shock protein, putative 0.0015 0.003 0.2364
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Trichomonas vaginalis taga, putative 0.0014 0.0027 0.2144
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Schistosoma mansoni flap endonuclease-1 0.0011 0.0016 0.0016
Trypanosoma brucei heat shock protein, putative 0.0015 0.003 0.2364
Echinococcus granulosus lipoxygenase domain containing protein 0.0501 0.1714 0.1714
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0154
Schistosoma mansoni lipoxygenase 0.2894 1 1
Echinococcus granulosus flap endonuclease 1 0.0012 0.002 0.002
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0027 0.2144
Mycobacterium ulcerans DNA polymerase IV 0.0036 0.0103 0.1708
Brugia malayi serine/threonine-protein kinase plk-2 0.0042 0.0126 0.0735
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Echinococcus granulosus chromobox protein 1 0.0031 0.0087 0.0087
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0068 0.0838
Leishmania major heat shock protein 83-1 0.0015 0.003 0.2364
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0042 0.0126 0.0126
Trichomonas vaginalis abcb9, putative 0.0014 0.0027 0.2144
Entamoeba histolytica P-glycoprotein-1 0.0014 0.0027 0.2144
Mycobacterium leprae Conserved hypothetical protein 0.0511 0.1748 1
Leishmania major DNA polymerase kappa, putative 0.0027 0.0072 0.5712
Trichomonas vaginalis chromobox protein, putative 0.0019 0.0045 0.3537
Echinococcus granulosus transportin 1 0.0007 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0501 0.1714 0.1714
Echinococcus granulosus heat shock protein 0.0015 0.003 0.003
Schistosoma mansoni chromobox protein 0.0031 0.0087 0.0087
Toxoplasma gondii perforin-like protein PLP1 0.024 0.0812 1
Onchocerca volvulus Phospholipase A2 homolog 0.035 0.119 0.6945
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0014 0.0027 0.0027
Trichomonas vaginalis flap endonuclease-1, putative 0.0012 0.002 0.1568

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2311 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3109 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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