Detailed information for compound 155081

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 355.904 | Formula: C20H20ClN2S-
  • H donors: 0 H acceptors: 1 LogP: 4.8 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)C1CN2CCCC2c2c1cccc2C#N.[Cl-]
  • InChi: 1S/C20H20N2S.ClH/c1-23-16-9-7-14(8-10-16)18-13-22-11-3-6-19(22)20-15(12-21)4-2-5-17(18)20;/h2,4-5,7-10,18-19H,3,6,11,13H2,1H3;1H/p-1
  • InChiKey: NDROAFPXUAHLBM-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0037 0.0258 0.0917
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0181 0.0172
Echinococcus multilocularis serotonin transporter 0.0219 0.2091 0.2084
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.144 0.4895
Onchocerca volvulus 0.0231 0.2208 0.9892
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0092 0.0082
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0092 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0092 0.0265
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.2839 1
Onchocerca volvulus 0.005 0.0386 0.1378
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0404 0.0399
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0092 0.0029
Toxoplasma gondii hypothetical protein 0.0047 0.036 0.4125
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.019 0.1803 0.613
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0175 0.0381
Entamoeba histolytica Ran family GTPase 0.0069 0.0581 0.8795
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0299 0.0851
Echinococcus multilocularis sodium and chloride dependent glycine 0.0037 0.0258 0.0248
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0175 0.4242
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0181 0.012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0092 0.0265
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0092 0.0265
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0181 0.0172
Brugia malayi glutathione reductase 0.0083 0.0725 0.2745
Leishmania major importin beta-1 subunit, putative 0.0076 0.0652 0.2122
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0092 0.0082
Brugia malayi jmjC domain containing protein 0.0019 0.0074 0.0195
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.0253
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0092 0.0029
Echinococcus multilocularis thioredoxin glutathione reductase 0.0084 0.073 0.0721
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0303 0.2942 1
Echinococcus multilocularis transportin 1 0.0018 0.0062 0.0052
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.0442 0.0433
Plasmodium falciparum glutathione reductase 0.0029 0.0175 0.1464
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0043 0.0315 0.1071
Schistosoma mansoni cpg binding protein 0.0028 0.0169 0.0107
Loa Loa (eye worm) hypothetical protein 0.014 0.13 0.1295
Mycobacterium ulcerans hypothetical protein 0.0303 0.2942 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1819 0.1768
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0619 0.056
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0024 0.0019
Loa Loa (eye worm) kap beta 3 protein 0.0018 0.0062 0.0057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.0253
Loa Loa (eye worm) pax transcription factor protein 2 0.0233 0.2231 0.2227
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.05 0.0441
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0169 0.0164
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.019 0.1803 0.613
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0212 0.2018 0.6858
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0092 0.0029
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0055 0.0442 0.1367
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0037 0.0258 0.0253
Toxoplasma gondii HEAT repeat-containing protein 0.0094 0.0831 1
Echinococcus multilocularis Aminotransferase class III 0.0043 0.0318 0.0308
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0175 0.1464
Echinococcus multilocularis ornithine aminotransferase 0.0043 0.0318 0.0308
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.003 0.019 0.0646
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0474 0.5544
Brugia malayi jmjC domain containing protein 0.0192 0.1817 0.7021
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0175 0.1464
Plasmodium vivax ornithine aminotransferase, putative 0.0043 0.0318 0.3327
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0092 0.0087
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0181 0.012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0092 0.0029
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0074 0.0148
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0175 0.0405
Brugia malayi Pre-SET motif family protein 0.0203 0.1926 0.7448
Treponema pallidum sodium- and chloride- dependent transporter 0.0219 0.2091 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0037 0.0258 0.0197
Trypanosoma brucei importin beta-1 subunit, putative 0.0094 0.0831 0.2768
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0092 0.0087
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0175 0.0405
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0175 0.0405
Schistosoma mansoni hypothetical protein 0.0404 0.3955 0.3918
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0092 0.0082
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.0442 0.0433
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.0253
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0436 0.507
Echinococcus multilocularis importin 5 0.0018 0.0062 0.0052
Brugia malayi TAR-binding protein 0.0073 0.0619 0.2329
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0055 0.0442 0.0382
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0548 0.0543
Onchocerca volvulus Fatty acid synthase homolog 0.0052 0.0404 0.1462
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0028 0.0163 0.0555
Onchocerca volvulus 0.0233 0.2231 1
Schistosoma mansoni hypothetical protein 0.0065 0.0539 0.0479
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0092 0.0082
Plasmodium falciparum glutathione reductase 0.0083 0.0725 0.8622
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0303 0.2942 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0092 0.0029
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0076 0.005
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.1102 0.1098
Loa Loa (eye worm) carboxylesterase 0.0066 0.0548 0.0543
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0074 0.0069
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0037 0.0258 0.2854
Echinococcus granulosus serotonin transporter 0.0219 0.2091 0.2084
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0092 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.1819 0.1811
Mycobacterium tuberculosis Probable dehydrogenase 0.019 0.1803 0.613
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0175 0.0367
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0175 0.0165
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0175 0.0367
Trypanosoma brucei importin beta-1 subunit, putative 0.0094 0.0831 0.2768
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0303 0.2942 1
Brugia malayi Pax transcription factor protein 2 0.0233 0.2231 0.864
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0069 0.0236
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0069 0.0119
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0037 0.0258 0.0248
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0029 0.0172 0.0358
Schistosoma mansoni sodium/chloride dependent transporter 0.0219 0.2091 0.2042
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0069 0.0581 0.0576
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0092 0.0087
Echinococcus granulosus FTZ F1 alpha 0.043 0.4224 0.4218
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0175 0.0381
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0074 0.0555
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0074 0.0069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0212 0.2018 0.6777
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0092 0.0087
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0092 0.0087
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.003 0.019 0.0404
Mycobacterium ulcerans Type I modular polyketide synthase 0.0029 0.0172 0.0358
Echinococcus granulosus dnaJ subfamily B 0.0404 0.3955 0.395
Brugia malayi ecdysteroid receptor 0.0021 0.0092 0.0265
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0037 0.0258 0.0248
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0092 0.0082
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0069 0.0581 0.6879
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0092 0.0082
Schistosoma mansoni cpg binding protein 0.003 0.0185 0.0124
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0074 0.0069
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0175 0.0113
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0069 0.0064
Brugia malayi PHD-finger family protein 0.0059 0.0474 0.1761
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0303 0.2942 1
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.0614 0.0605
Echinococcus granulosus lamin 0.0026 0.0146 0.0136
Schistosoma mansoni coup transcription factor 0.0021 0.0092 0.0029
Trypanosoma brucei trypanothione reductase 0.0083 0.0725 0.2386
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0539 0.2016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0181 0.012
Echinococcus granulosus phd:f box containing protein 0.0019 0.0074 0.0064
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0069 0.006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.0253
Echinococcus granulosus GPCR family 2 0.0065 0.0539 0.0529
Onchocerca volvulus 0.0027 0.0153 0.0288
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0175 0.0381
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0029 0.0172 0.0341
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0074 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0005
Schistosoma mansoni jumonji domain containing protein 0.0152 0.142 0.1366
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0069 0.0581 0.1867
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0092 0.0082
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.003 0.019 0.0646
Brugia malayi hypothetical protein 0.0035 0.0234 0.0821
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0206 0.1955 0.7563
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1282 0.4393
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0043 0.0318 0.0865
Onchocerca volvulus 0.003 0.0181 0.0421
Schistosoma mansoni cpg binding protein 0.003 0.0185 0.0124
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.2839 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0219 0.2091 0.8095
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0037 0.0258 0.0248
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0037 0.0258 0.2854
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0074 0.0064
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0614 0.0609
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0074 0.0011
Entamoeba histolytica hypothetical protein 0.0035 0.0234 0.2906
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1819 0.1768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.1819 0.1811
Onchocerca volvulus 0.0026 0.0146 0.0254
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0175 0.0165
Plasmodium vivax JmjC domain containing protein 0.0019 0.0074 0.0148
Echinococcus granulosus importin subunit beta 1 0.0094 0.0831 0.0822
Brugia malayi Carboxylesterase family protein 0.0066 0.0548 0.2051
Loa Loa (eye worm) solute carrier family 6 member 4 0.0219 0.2091 0.2087
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0043 0.0318 0.3602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.1819 0.1768
Echinococcus granulosus translational activator gcn1 0.0018 0.0062 0.0052
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.1817 0.1809
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0055 0.0442 0.1502
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0092 0.0265
Plasmodium vivax glutathione reductase, putative 0.0083 0.0725 0.8622
Brugia malayi Bromodomain containing protein 0.0059 0.0474 0.1761
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0092 0.0082
Echinococcus granulosus importin 5 0.0018 0.0062 0.0052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0092 0.0265
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0037 0.0258 0.0248
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0043 0.0318 0.1081
Plasmodium falciparum phd finger protein, putative 0.0059 0.0474 0.5352
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0174 0.0589
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0474 0.0414
Brugia malayi jmjC domain containing protein 0.0019 0.0074 0.0195
Mycobacterium leprae Probable polyketide synthase Pks1 0.003 0.019 0.0404
Brugia malayi CXXC zinc finger family protein 0.0028 0.0169 0.0568
Leishmania major GTP-binding protein, putative 0.0069 0.0581 0.1867
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0539 0.0529
Echinococcus multilocularis musashi 0.0026 0.0146 0.0136
Plasmodium falciparum ornithine aminotransferase 0.0043 0.0318 0.3327
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0474 0.0469
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.13 0.4995
Loa Loa (eye worm) hypothetical protein 0.0048 0.0369 0.0364
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0069 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0175 0.0381
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0539 0.0534
Plasmodium vivax SET domain protein, putative 0.003 0.0181 0.1551
Loa Loa (eye worm) RNA binding protein 0.0073 0.0619 0.0614
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0548 0.0488
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0027 0.0153 0.0521
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0074 0.0064
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0175 0.0391
Schistosoma mansoni sodium/chloride dependent transporter 0.0037 0.0258 0.0197
Loa Loa (eye worm) hypothetical protein 0.0219 0.2091 0.2087
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0029 0.0172 0.0585
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0619 0.056
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0614 0.0555
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0175 0.0381
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0619 0.2329
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.1819 0.703
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0175 0.2063
Treponema pallidum NADH oxidase 0.0029 0.0175 0.0522
Loa Loa (eye worm) hypothetical protein 0.0066 0.0548 0.0543
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0037 0.0258 0.0197
Schistosoma mansoni intermediate filament proteins 0.0026 0.0146 0.0084
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0037 0.0258 0.0197
Schistosoma mansoni ap endonuclease 0.0018 0.0069 0.0007
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0019 0.0074 0.0017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0092 0.0029
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0146 0.0141
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.1819 0.1815
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0043 0.0318 0.085
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0141
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0037 0.0258 0.0248
Loa Loa (eye worm) hypothetical protein 0.0066 0.0548 0.0543
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0175 0.1464
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0069 0.0024
Brugia malayi hypothetical protein 0.0037 0.0258 0.0917
Echinococcus multilocularis snurportin 1 0.1003 1 1
Toxoplasma gondii hypothetical protein 0.0037 0.0258 0.2854
Mycobacterium ulcerans thioesterase TesA 0.0024 0.0124 0.019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0092 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0092 0.0265
Giardia lamblia PHD finger protein 15 0.0059 0.0474 0.7907
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0043 0.0315 0.1071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0092 0.0265
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0074 0.0011
Entamoeba histolytica hypothetical protein 0.0035 0.0234 0.2906
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0037 0.0258 0.0197
Mycobacterium ulcerans Type I modular polyketide synthase 0.0029 0.0172 0.0358
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.003 0.019 0.0421
Brugia malayi jmjC domain containing protein 0.0072 0.0614 0.2311
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.0069
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0069 0.0091
Trichomonas vaginalis importin beta-1, putative 0.0076 0.0652 0.2046
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0037 0.0258 0.0248
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0539 0.0529
Echinococcus granulosus Aminotransferase class III 0.0043 0.0318 0.0308
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0092 0.0265
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0092 0.0029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0175 0.0381
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0092 0.0029
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0037 0.0258 0.0248
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0069 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0092 0.0087
Loa Loa (eye worm) norepinephrine transporter 0.0219 0.2091 0.2087
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0074 0.0041
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0029 0.0172 0.0341
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0029 0.0172 0.0581
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0175 0.1816
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Echinococcus granulosus sodium and chloride dependent glycine 0.0037 0.0258 0.0248
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.0069
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0175 0.0405
Schistosoma mansoni hypothetical protein 0.0173 0.1628 0.1576
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0023 0.0116 0.0144
Schistosoma mansoni ap endonuclease 0.0018 0.0069 0.0007
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0092 0.0029
Loa Loa (eye worm) hypothetical protein 0.0059 0.0474 0.0469
Echinococcus granulosus cpg binding protein 0.003 0.0185 0.0176
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0539 0.0529
Plasmodium vivax thioredoxin reductase, putative 0.0083 0.0725 0.8622
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0092 0.0265
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0474 0.0464
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0043 0.0318 1
Echinococcus granulosus peregrin 0.0059 0.0474 0.0464
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.009 0.008
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0212 0.2018 0.6858
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0234 0.0224
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0146 0.0141
Loa Loa (eye worm) glutathione reductase 0.0083 0.0725 0.072
Echinococcus multilocularis lamin dm0 0.0026 0.0146 0.0136
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0705 0.0696
Schistosoma mansoni hypothetical protein 0.0035 0.0234 0.0172
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0175 0.0391
Onchocerca volvulus 0.0028 0.0169 0.0362
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0092 0.0082
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0175 0.0591
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0092 0.0082
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0043 0.0318 0.1081
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0076 0.0585
Echinococcus granulosus GTP binding nuclear protein Ran 0.0069 0.0581 0.0571
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0069 0.0025
Brugia malayi RNA, U transporter 1 0.0267 0.2578 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0181 0.012
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0043 0.0318 0.1081
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0164 0.0155
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0037 0.0258 0.0253
Echinococcus multilocularis peregrin 0.0059 0.0474 0.0464
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0043 0.0318 0.0257
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0705 0.0696
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0092 0.0082
Entamoeba histolytica hypothetical protein 0.0076 0.0652 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0069 0.0581 0.1846
Brugia malayi intermediate filament protein 0.0026 0.0146 0.0478
Echinococcus granulosus tar DNA binding protein 0.0073 0.0619 0.0609
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0076 0.0652 0.2046
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0027 0.0153 0.0148
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0074 0.0011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0539 0.2016
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0474 0.5544
Plasmodium vivax importin-beta 2, putative 0.0094 0.0831 1
Plasmodium falciparum amino acid transporter, putative 0.0037 0.0258 0.2546
Schistosoma mansoni ran 0.0069 0.0581 0.0521
Toxoplasma gondii HEAT repeat-containing protein 0.0018 0.0062 0.0413
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0016 0.0047 0.0161
Mycobacterium ulcerans polyketide synthase Pks13 0.0043 0.0315 0.0856
Plasmodium falciparum transporter, putative 0.0037 0.0258 0.2546
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0175 0.0405
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.3955 0.395
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0043 0.0318 0.085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0092 0.0087
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.2839 1
Brugia malayi steroid hormone receptor 0.0021 0.0092 0.0265
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0619 0.056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0175 0.0381
Brugia malayi RNA binding protein 0.0073 0.0619 0.2329
Loa Loa (eye worm) hypothetical protein 0.0026 0.0141 0.0136
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0074 0.0555
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0175 0.1816
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2208 0.745
Mycobacterium ulcerans polyketide synthase 0.0029 0.0172 0.0358
Mycobacterium ulcerans L-lysine aminotransferase 0.0043 0.0318 0.0865
Schistosoma mansoni lamin 0.0026 0.0146 0.0084
Schistosoma mansoni hypothetical protein 0.0059 0.0474 0.0414
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0548 0.0538
Loa Loa (eye worm) serotonin transporter b 0.0219 0.2091 0.2087
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0043 0.0318 0.1152
Schistosoma mansoni hypothetical protein 0.0065 0.0539 0.0479
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0175 0.0367
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0175 0.4242
Mycobacterium ulcerans acetylornithine aminotransferase 0.0043 0.0318 0.0865
Echinococcus granulosus geminin 0.0173 0.1628 0.162
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0539 0.0529
Brugia malayi nuclear hormone receptor 0.0021 0.0092 0.0265
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0219 0.2091 0.2042
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0175 0.0405
Toxoplasma gondii hypothetical protein 0.0037 0.0258 0.2854
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0037 0.0258 0.0917
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0619 0.056
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0092 0.0029
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.0442 0.1297
Schistosoma mansoni hypothetical protein 0.0019 0.0076 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0258 0.2546
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0092 0.0265
Trichomonas vaginalis ran, putative 0.0069 0.0581 0.18
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0043 0.0318 0.0865
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.0089 0.0745
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0029 0.0172 0.0585
Mycobacterium ulcerans hypothetical protein 0.0154 0.144 0.4771
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.1817 0.1809
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.019 0.1803 0.6029
Plasmodium falciparum thioredoxin reductase 0.0029 0.0175 0.1464
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1926 0.1922
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0054 0.0431 0.1594
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0097 0.0288
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0092 0.0082
Loa Loa (eye worm) hypothetical protein 0.0219 0.2091 0.2087
Mycobacterium ulcerans polyketide synthase 0.003 0.019 0.0421
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0043 0.0318 0.0865
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0474 0.5352
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0043 0.0318 0.0865
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.0253
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0083 0.0725 0.2464
Brugia malayi jmjC domain containing protein 0.0019 0.0074 0.0195
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0074 0.0064
Toxoplasma gondii HEAT repeat-containing protein 0.0018 0.0062 0.0413
Brugia malayi kap beta 3 protein 0.0018 0.0062 0.0151
Echinococcus multilocularis lamin 0.0026 0.0146 0.0136
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.009 0.008
Echinococcus granulosus acetylcholinesterase 0.0066 0.0548 0.0538
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0092 0.0029
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.1819 0.1811
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0181 0.0172
Onchocerca volvulus 0.0219 0.2091 0.9349
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1282 0.4393
Echinococcus multilocularis ornithine aminotransferase 0.0043 0.0318 0.0308
Echinococcus multilocularis sodium and chloride dependent glycine 0.0037 0.0258 0.0248
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0043 0.0318 0.085
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0175 0.0405
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0074 0.0064
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.039 0.1156
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0092 0.0082
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0234 0.0224
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0175 0.0381
Brugia malayi Pre-SET motif family protein 0.003 0.0181 0.0617
Loa Loa (eye worm) hypothetical protein 0.0021 0.0092 0.0087
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0299 0.0828
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0019 0.0071 0.0517
Echinococcus granulosus lamin dm0 0.0026 0.0146 0.0136
Mycobacterium ulcerans Type I modular polyketide synthase 0.0029 0.0172 0.0358
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.019 0.1803 0.613
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0023 0.0116 0.0161
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0069 0.006
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0076 0.0652 0.2046
Mycobacterium tuberculosis Polyketide synthase Pks12 0.003 0.019 0.0646
Loa Loa (eye worm) hypothetical protein 0.0094 0.0831 0.0826
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0037 0.0258 0.0917
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0069 0.0178
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0037 0.0258 0.0917
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0175 0.1464
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0069 0.0581 0.1846
Trypanosoma cruzi importin beta-1 subunit, putative 0.0076 0.0652 0.2102
Plasmodium falciparum importin beta, putative 0.0094 0.0831 1
Echinococcus multilocularis importin subunit beta 1 0.0094 0.0831 0.0822
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.1003 1 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0094 0.0406
Schistosoma mansoni hypothetical protein 0.014 0.13 0.1245
Schistosoma mansoni importin beta-1 0.0094 0.0831 0.0773
Onchocerca volvulus 0.0026 0.0146 0.0254
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0619 0.056
Plasmodium falciparum thioredoxin reductase 0.0083 0.0725 0.8622
Echinococcus granulosus thioredoxin glutathione reductase 0.0084 0.073 0.0721
Brugia malayi Importin beta-1 subunit 0.0094 0.0831 0.3159
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0442 0.1637
Echinococcus multilocularis GPCR, family 2 0.0065 0.0539 0.0529
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0023 0.012 0.0406
Mycobacterium leprae Polyketide synthase Pks13 0.0043 0.0315 0.084
Brugia malayi jmjC domain containing protein 0.0019 0.0074 0.0195
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0037 0.0258 0.0197
Schistosoma mansoni sodium-dependent amino acid transporter 0.0037 0.0258 0.0197
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0092 0.0265
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0074 0.0064
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.003 0.019 0.0404
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.003 0.019 0.0421
Entamoeba histolytica hypothetical protein 0.0035 0.0234 0.2906
Schistosoma mansoni ran 0.0069 0.0581 0.0521
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0619 0.0609
Echinococcus granulosus intermediate filament protein 0.0026 0.0146 0.0136
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0076 0.0585
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0037 0.0258 0.5809
Entamoeba histolytica hypothetical protein 0.0035 0.0234 0.2906
Brugia malayi Thioredoxin reductase 0.0083 0.0725 0.2745
Onchocerca volvulus 0.0037 0.0258 0.0778
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0234 0.0172
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0299 0.0828
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0092 0.0082
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0069 0.0581 0.218
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0092 0.0082
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0158 0.0096
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0069 0.0581 1
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0021 0.0091 0.0309
Trypanosoma cruzi trypanothione reductase, putative 0.0083 0.0725 0.2367
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0598 0.0589
Plasmodium vivax amine transporter, putative 0.0037 0.0258 0.2546
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0037 0.0258 0.0197
Echinococcus granulosus acetylcholinesterase 0.0066 0.0548 0.0538
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0092 0.0029
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0037 0.0258 0.2854
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0074 0.0011
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0037 0.0258 0.0197
Mycobacterium tuberculosis Probable oxidoreductase 0.0212 0.2018 0.6858
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0092 0.0265
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0074 0.0064
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0175 0.0594
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0023 0.0116 0.0161
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0074 0.0064
Brugia malayi AF-10 protein 0.0019 0.0076 0.0205
Echinococcus granulosus transportin 1 0.0018 0.0062 0.0052
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.004
Mycobacterium tuberculosis Probable thioesterase TesA 0.0024 0.0124 0.0421
Brugia malayi Calcitonin receptor-like protein seb-1 0.0206 0.1955 0.7563
Echinococcus multilocularis translational activator gcn1 0.0018 0.0062 0.0052
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0614 0.0555
Onchocerca volvulus 0.0037 0.0258 0.0778
Mycobacterium tuberculosis Probable reductase 0.019 0.1803 0.613
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.2839 1
Onchocerca volvulus Alhambra homolog 0.0059 0.0474 0.1786
Mycobacterium ulcerans thioesterase 0.0024 0.0124 0.019
Mycobacterium ulcerans polyketide synthase Pks9 0.0019 0.0074 0.0017
Mycobacterium tuberculosis Putative ferredoxin reductase 0.019 0.1803 0.613
Echinococcus granulosus ornithine aminotransferase 0.0043 0.0318 0.0308
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0024 0.0124 0.0173
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0074 0.0016
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0181 0.19
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0092 0.0265
Loa Loa (eye worm) fatty acid synthase 0.0028 0.0168 0.0163
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1282 0.4378
Leishmania major hypothetical protein, conserved 0.0019 0.0074 0.0041
Brugia malayi PHD-finger family protein 0.0021 0.0092 0.0268
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0028 0.0163 0.0555
Toxoplasma gondii thioredoxin reductase 0.0083 0.0725 0.8679
Loa Loa (eye worm) hypothetical protein 0.003 0.0181 0.0177
Echinococcus multilocularis geminin 0.0173 0.1628 0.162
Loa Loa (eye worm) hypothetical protein 0.01 0.0895 0.0891
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.0253
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0097 0.0288
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0037 0.0258 0.0197
Loa Loa (eye worm) hypothetical protein 0.0219 0.2091 0.2087
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0299 0.0828
Toxoplasma gondii type I fatty acid synthase, putative 0.003 0.019 0.2008
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0092 0.0265
Schistosoma mansoni lamin 0.0026 0.0146 0.0084
Brugia malayi Carboxylesterase family protein 0.0066 0.0548 0.2051
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0548 0.0538
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0619 0.0614
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0548 0.0538
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0619 0.0614
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0074 0.0016
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0474 0.0464
Mycobacterium tuberculosis Probable aminotransferase 0.0303 0.2942 1
Onchocerca volvulus 0.0037 0.0258 0.0778
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.0442 0.1297
Echinococcus multilocularis cpg binding protein 0.003 0.0185 0.0176
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0069 0.0581 0.6744
Loa Loa (eye worm) hypothetical protein 0.0065 0.0539 0.0534
Loa Loa (eye worm) thioredoxin reductase 0.0083 0.0725 0.072
Schistosoma mansoni sodium/chloride dependent transporter 0.0037 0.0258 0.0197
Loa Loa (eye worm) hypothetical protein 0.0206 0.1955 0.1951
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0092 0.0082
Echinococcus granulosus sodium and chloride dependent glycine 0.0037 0.0258 0.0248
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.0253
Schistosoma mansoni hypothetical protein 0.0065 0.0539 0.0479
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0092 0.0265
Toxoplasma gondii exonuclease III APE 0.0018 0.0069 0.0501
Brugia malayi nuclear receptor NHR-88 0.0021 0.0092 0.0265
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.7945 0.7943
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0029 0.0172 0.0585
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0043 0.0318 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.1819 0.1811
Leishmania major trypanothione reductase 0.0083 0.0725 0.2386
Schistosoma mansoni hypothetical protein 0.1003 1 1
Schistosoma mansoni hypothetical protein 0.0065 0.0539 0.0479
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0069 0.0581 0.0571
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0043 0.0318 0.1081
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0094 0.0406
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0146 0.0478
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0548 0.0538
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0175 0.0405
Loa Loa (eye worm) importin-beta domain-containing protein 0.0018 0.0062 0.0057
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0175 0.0381
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0069 0.0091
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0153 0.0506
Schistosoma mansoni hypothetical protein 0.0173 0.1628 0.1576
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0069 0.0581 0.6744
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0076 0.005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0206 0.1955 0.1951
Loa Loa (eye worm) acyl carrier protein 0.0013 0.0016 0.0011

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 5 mg kg-1 Tested in vivo for head twitches antagonizing activity in mice ChEMBL. 2213832
Ki (binding) = 14.7 nM Tested in vitro for serotonin(5-HT) neuronal uptake inhibition ChEMBL. 2213832
Ki (binding) = 390 nM Tested in vitro for norepinephrine(NE) neuronal uptake inhibition ChEMBL. 2213832
Ki (binding) = 2800 nM Tested in vitro for dopamine(DA) neuronal uptake inhibition ChEMBL. 2213832

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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