Detailed information for compound 1558252

Basic information

Technical information
  • TDR Targets ID: 1558252
  • Name: 3-(6H-benzo[c][1,5]benzodithiepin-6-yl)-N,N-d imethylpropan-1-amine; oxalic acid
  • MW: 405.531 | Formula: C20H23NO4S2
  • H donors: 2 H acceptors: 4 LogP: 2.33 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(=O)O.CN(CCCC1Sc2ccccc2Sc2c1cccc2)C
  • InChi: 1S/C18H21NS2.C2H2O4/c1-19(2)13-7-12-16-14-8-3-4-9-15(14)20-17-10-5-6-11-18(17)21-16;3-1(4)2(5)6/h3-6,8-11,16H,7,12-13H2,1-2H3;(H,3,4)(H,5,6)
  • InChiKey: NHSGUJVGSKQLLR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(6H-benzo[c][1,5]benzodithiepin-6-yl)-N,N-dimethyl-propan-1-amine; oxalic acid
  • 3-(6H-benzo[c][1,5]benzodithiepin-6-yl)propyl-dimethyl-amine; oxalic acid
  • 3-(6H-benzo[c][1,5]benzodithiepin-6-yl)-N,N-dimethyl-propan-1-amine; ethanedioic acid
  • 81890-73-5
  • 11-(3-Dimethylaminopropyl)-11H-dibenzo(b,e)-1,4-dithiepin hydrogen oxalate
  • 11H-Dibenzo(b,e)(1,4)dithiepin-11-propanamine, N,N-dimethyl-, ethanedioate (1:1)
  • N,N-Dimethyl-11H-dibenzo(b,e)(1,4)dithiepin-11-propanamine oxalate
  • MLS001180186
  • N-[3-(11H-dibenzo[b,e][1,4]dithiepin-11-yl)propyl]-N,N-dimethylamine
  • SMR000475947

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.0036
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0032 0.0019
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0429 0.1039
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0418 0.042
Echinococcus multilocularis peregrin 0.0038 0.028 0.0279
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0122 0.011
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0055 0.0055
Loa Loa (eye worm) glutaminase 0.0839 1 1
Leishmania major cathepsin L-like protease 0.0018 0.0036 0.0088
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0297 0.0297
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1222 0.1239
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.1193 0.837
Brugia malayi glutaminase DH11.1 0.0839 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0603 0.0591
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0032 0.0077
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0251 0.0278
Echinococcus multilocularis GPCR, family 2 0.0019 0.0055 0.005
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0193 0.4295
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0261 0.4231
Trypanosoma brucei trypanothione reductase 0.005 0.0424 0.1027
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.058 0.0586
Brugia malayi Cathepsin L-like precursor 0.0018 0.0036 0.0036
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0019 0.0045
Brugia malayi Pre-SET motif family protein 0.0063 0.0591 0.0591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0634 0.1535
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.0036
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0036 0.0088
Brugia malayi isocitrate dehydrogenase 0.0016 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.003 0.0193 0.0193
Plasmodium falciparum thioredoxin reductase 0.0017 0.0032 0.0324
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0036 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0634 0.1535
Leishmania major mitochondrial DNA polymerase beta 0.0355 0.4128 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0591 0.0579
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0591 0.0596
Mycobacterium ulcerans hypothetical protein 0.0048 0.0409 0.0378
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0047 0.0137
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0297 0.0297
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.1193 0.5668
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0168 0.1861 0.4508
Entamoeba histolytica cysteine protease, putative 0.0018 0.0036 0.0129
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0384 0.0372
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0019 0.0014
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0036 0.0032
Brugia malayi hypothetical protein 0.002 0.0062 0.0062
Onchocerca volvulus Glycogen phosphorylase homolog 0.0247 0.282 0.4815
Loa Loa (eye worm) ctsf protein 0.0018 0.0036 0.0036
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0261 0.5972
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.1346 0.6406
Schistosoma mansoni hypothetical protein 0.0021 0.0078 0.0066
Loa Loa (eye worm) fibroinase 0.0018 0.0036 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0237 0.1053
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0297 0.1053
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0032 0.023
Schistosoma mansoni cpg binding protein 0.0033 0.0222 0.021
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Echinococcus granulosus glycogen phosphorylase 0.0247 0.282 0.3186
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0418 0.0467
Leishmania major cathepsin L-like protease 0.0067 0.0634 0.1535
Leishmania major cathepsin L-like protease 0.0018 0.0036 0.0088
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0122 0.0119
Leishmania major cathepsin L-like protease 0.0067 0.0634 0.1535
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.0036
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0297 0.033
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0036 0.0032
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0036 0.0032
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0934 0.0923
Brugia malayi Bromodomain containing protein 0.0038 0.028 0.028
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.1193 0.5668
Trypanosoma brucei glucosidase, putative 0.0039 0.0297 0.072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.094 0.0929
Schistosoma mansoni glycogen phosphorylase 0.0247 0.282 0.2811
Schistosoma mansoni lipoxygenase 0.012 0.1279 0.1268
Onchocerca volvulus 0.0152 0.1663 0.2839
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0193 0.0467
Loa Loa (eye worm) hypothetical protein 0.0045 0.037 0.037
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1222 0.1376
Schistosoma mansoni lipoxygenase 0.0084 0.0841 0.0829
Onchocerca volvulus 0.0102 0.1057 0.1805
Onchocerca volvulus 0.0048 0.0409 0.0698
Echinococcus granulosus glycogen phosphorylase 0.0247 0.282 0.3186
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.1957 0.1987
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0251 0.4052
Loa Loa (eye worm) hypothetical protein 0.0048 0.0409 0.0409
Trichomonas vaginalis glycogen phosphorylase, putative 0.0247 0.282 0.282
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0034 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0237 0.1053
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0297 0.0297
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0297 0.0297
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0019 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.094 0.1058
Schistosoma mansoni hypothetical protein 0.0019 0.0055 0.0042
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0424 0.0424
Plasmodium vivax glutathione reductase, putative 0.005 0.0424 0.7085
Loa Loa (eye worm) cysteine protease 0.0018 0.0036 0.0036
Plasmodium falciparum glutathione reductase 0.0017 0.0032 0.0324
Schistosoma mansoni alpha-glucosidase 0.0151 0.166 0.1649
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0032 0.0077
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0081 0.0801 0.0811
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0176 0.1957 0.1957
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0019 0.0015
Entamoeba histolytica glycogen phosphorylase, putative 0.0247 0.282 1
Brugia malayi Pre-SET motif family protein 0.0437 0.5126 0.5126
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0297 0.1053
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0409 0.0378
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.0036
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0178 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0634 0.1535
Leishmania major cathepsin L-like protease 0.0067 0.0634 0.1535
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0036 0.0437
Giardia lamblia PHD finger protein 15 0.0035 0.0251 0.0785
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0409 0.0378
Loa Loa (eye worm) glycogen phosphorylase 0.0247 0.282 0.282
Brugia malayi Cathepsin L-like precursor 0.0018 0.0036 0.0036
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.07 0.0708
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0036 0.0035
Schistosoma mansoni survival motor neuron protein 0.0152 0.1663 0.1653
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0261 0.023
Plasmodium vivax SET domain protein, putative 0.0063 0.0591 1
Brugia malayi Muscleblind-like protein 0.0296 0.341 0.341
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0297 0.0297
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0055 0.0056
Echinococcus multilocularis zinc finger protein 0.0022 0.0085 0.0082
Loa Loa (eye worm) hypothetical protein 0.0072 0.0696 0.0696
Brugia malayi glutathione reductase 0.005 0.0424 0.0424
Echinococcus granulosus survival motor neuron protein 1 0.0744 0.8842 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0297 0.072
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0634 0.1535
Onchocerca volvulus 0.0158 0.1742 0.2974
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0061 0.0561 0.136
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.046 0.1115
Leishmania major hypothetical protein, conserved 0.003 0.0193 0.0467
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0067 0.0844
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0055 0.0055
Schistosoma mansoni rab6-interacting 0.002 0.0067 0.0055
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.094 0.094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0634 0.1535
Loa Loa (eye worm) hypothetical protein 0.0744 0.8842 0.8842
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0297 0.0297
Echinococcus multilocularis survival motor neuron protein 1 0.0744 0.8842 0.8998
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0429 0.1039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0048 0.0409 0.0409
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0267 0.0266
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0424 0.0426
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0047 0.0496
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0047 0.0015
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0168 0.1861 0.4508
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0297 0.4864
Brugia malayi jmjC domain containing protein 0.0046 0.0384 0.0384
Echinococcus granulosus dnaJ subfamily B 0.0416 0.4869 0.5504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0409 0.1882
Schistosoma mansoni alpha glucosidase 0.0039 0.0297 0.0285
Loa Loa (eye worm) hypothetical protein 0.0035 0.0251 0.0251
Toxoplasma gondii exonuclease III APE 0.0018 0.0047 0.0496
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0591 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0297 0.0297
Brugia malayi hypothetical protein 0.002 0.0067 0.0067
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0152 0.1663 0.1663
Mycobacterium ulcerans hypothetical protein 0.0187 0.2091 0.2066
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0032 0.0032
Schistosoma mansoni ap endonuclease 0.0018 0.0047 0.0035
Plasmodium falciparum glutathione reductase 0.005 0.0424 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0047 0.0114
Mycobacterium tuberculosis Probable reductase 0.0113 0.1193 0.5668
Echinococcus granulosus arachidonate 5 lipoxygenase 0.012 0.1279 0.1441
Loa Loa (eye worm) hypothetical protein 0.0036 0.0261 0.0261
Schistosoma mansoni hypothetical protein 0.0041 0.0323 0.0311
Onchocerca volvulus 0.0018 0.0036 0.0062
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0032 0.0077
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.094 0.094
Schistosoma mansoni hypothetical protein 0.0019 0.0055 0.0042
Echinococcus multilocularis Glycosyl transferase, family 35 0.0247 0.282 0.2866
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.058 0.0651
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.0036
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0032 0.0032
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0825 0.9826 1
Onchocerca volvulus 0.0018 0.0036 0.0062
Brugia malayi PHD-finger family protein 0.0027 0.0151 0.0151
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0032 0.0077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.0077
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0067 0.0063
Leishmania major cathepsin L-like protease 0.0018 0.0036 0.0088
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0801 0.079
Brugia malayi jmjC domain containing protein 0.0115 0.1222 0.1222
Echinococcus multilocularis lysosomal alpha glucosidase 0.0176 0.1957 0.1987
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0055 0.005
Trypanosoma brucei DNA polymerase beta thumb, putative 0.005 0.0429 0.1039
Mycobacterium tuberculosis Conserved hypothetical protein 0.0187 0.2091 1
Brugia malayi PHD-finger family protein 0.0035 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0326
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.1193 0.5668
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0355 0.4128 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0178 0.0178
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0032 0.023
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0424 0.0474
Onchocerca volvulus 0.0498 0.5858 1
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0107 0.1119 0.1091
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0079 0.0067
Echinococcus granulosus peregrin 0.0038 0.028 0.0311
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0297 0.0297
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0297 0.072
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.1346 1
Schistosoma mansoni loxhd1 0.002 0.0067 0.0055
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0705 0.0705
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0036 0.0024
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0424 0.1027
Plasmodium vivax vivapain-2 0.0018 0.0036 0.0309
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0122 0.0132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0041 0.0323 0.0323
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.012 0.1279 0.1296
Leishmania major cathepsin L-like protease 0.0018 0.0036 0.0088
Brugia malayi Bromodomain containing protein 0.0078 0.0769 0.0769
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0032 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0634 0.1535
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0193 0.0467
Onchocerca volvulus 0.0029 0.0178 0.0304
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0261 0.1169
Loa Loa (eye worm) hypothetical protein 0.006 0.0555 0.0555
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0019 0.0045
Brugia malayi hypothetical protein 0.0072 0.07 0.07
Trypanosoma cruzi ISWI complex protein 0.0016 0.0012 0.003
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.034 0.0341
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0554 0.0554
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.4869 0.4952
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0634 0.1535
Schistosoma mansoni hypothetical protein 0.0152 0.1663 0.1653
Echinococcus granulosus cathepsin l1 0.0018 0.0036 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.0036
Brugia malayi hypothetical protein 0.0744 0.8842 0.8842
Echinococcus multilocularis cpg binding protein 0.0033 0.0222 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.0036
Echinococcus multilocularis glycogen phosphorylase 0.0247 0.282 0.2866
Entamoeba histolytica glycogen phosphorylase, putative 0.0247 0.282 1
Schistosoma mansoni cpg binding protein 0.0029 0.0178 0.0166
Loa Loa (eye worm) jmjC domain-containing protein 0.0046 0.0384 0.0384
Brugia malayi PHD-finger family protein 0.0015 0.0007 0.0007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0019 0.0014
Echinococcus granulosus histone lysine methyltransferase setb 0.0081 0.0801 0.0901
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.1193 0.5668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0205 0.2304 0.2295
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0036 0.0062
Brugia malayi Thioredoxin reductase 0.005 0.0424 0.0424
Brugia malayi hypothetical protein 0.0158 0.1742 0.1742
Brugia malayi Bromodomain containing protein 0.0039 0.0296 0.0296
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.094 0.1058
Onchocerca volvulus Alhambra homolog 0.0035 0.0251 0.0428
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0323 0.0323
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.0077
Onchocerca volvulus 0.0018 0.0036 0.0062
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0634 0.1535
Schistosoma mansoni hypothetical protein 0.0416 0.4869 0.4863
Loa Loa (eye worm) hypothetical protein 0.0296 0.341 0.341
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.0077
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0384 0.0372
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0297 0.0297
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0591 0.0579
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0193 0.3042
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0409 0.099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.002 0.0067 0.0055
Trichomonas vaginalis glutaminase, putative 0.0839 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0047 0.0047
Schistosoma mansoni glutaminase 0.0839 1 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0251 0.025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0634 0.1535
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.0036
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0355 0.4128 1
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0036 0.0088
Loa Loa (eye worm) hypothetical protein 0.0081 0.0801 0.0801
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0032 0.0077
Brugia malayi Doublecortin family protein 0.002 0.0067 0.0067
Echinococcus multilocularis geminin 0.0205 0.2304 0.2341
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.094 0.0952
Echinococcus multilocularis muscleblind protein 1 0.0296 0.341 0.3467
Echinococcus granulosus cpg binding protein 0.0033 0.0222 0.0245
Chlamydia trachomatis glycogen phosphorylase 0.0247 0.282 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.07 0.0786
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0409 0.099
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0067 0.007
Loa Loa (eye worm) hypothetical protein 0.0048 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0158 0.1742 0.1742
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0032 0.0027
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0409 0.1882
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0019 0.0006
Schistosoma mansoni hypothetical protein 0.0019 0.0055 0.0042
Schistosoma mansoni cpg binding protein 0.0033 0.0222 0.021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.094 0.0929
Schistosoma mansoni hypothetical protein 0.0205 0.2304 0.2295
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0019 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0634 0.1535
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0067 0.007
Loa Loa (eye worm) doublecortin family protein 0.002 0.0067 0.0067
Schistosoma mansoni glycogen phosphorylase 0.0107 0.1119 0.1108
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0554 0.0554
Schistosoma mansoni zinc finger protein 0.0022 0.0085 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.0036
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0251 0.4052
Entamoeba histolytica glycogenphosphorylase, putative 0.0107 0.1119 0.3969
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.0077
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Trypanosoma cruzi ISWI complex protein 0.0016 0.0012 0.003
Entamoeba histolytica hypothetical protein 0.0072 0.07 0.2483
Schistosoma mansoni glycogen phosphorylase 0.0247 0.282 0.2811
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0047 0.0043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0237 0.1053
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0424 0.7085
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.0077
Echinococcus granulosus RUN 0.002 0.0067 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.0036
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0554 0.0554
Loa Loa (eye worm) glutathione reductase 0.005 0.0424 0.0424
Trypanosoma brucei ISWI complex protein 0.0016 0.0012 0.003
Leishmania major hypothetical protein, conserved 0.0016 0.0012 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0634 0.1535
Loa Loa (eye worm) hypothetical protein 0.0296 0.341 0.341
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0409 0.0378
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0067 0.007
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0034 0.0033
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0036 0.0036
Brugia malayi hypothetical protein 0.003 0.0193 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.0036
Onchocerca volvulus 0.0018 0.0036 0.0062
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0297 0.0297
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0047 0.0114
Brugia malayi carbohydrate phosphorylase 0.0247 0.282 0.282
Echinococcus granulosus GPCR family 2 0.0019 0.0055 0.0056
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0047 0.0114
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0267 0.0296
Toxoplasma gondii hypothetical protein 0.0057 0.0518 0.8724
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.094 0.0952
Brugia malayi Cathepsin L-like precursor 0.0018 0.0036 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0409 0.0378
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0634 0.1535
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0032 0.0324
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0036 0.0036
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0047 0.0114
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0047 0.0167
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0019 0.0014
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0019 0.0045
Schistosoma mansoni rab6-interacting 0.002 0.0067 0.0055
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.0077
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0297 0.0297
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0067 0.0063
Schistosoma mansoni hypothetical protein 0.0072 0.07 0.0689
Echinococcus granulosus lysosomal alpha glucosidase 0.0176 0.1957 0.2208
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0409 0.0409
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0355 0.4128 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0047 0.0047
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0409 0.0409
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0034 0.0022
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0019 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0409 0.099
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0036 0.0036
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0047 0.0047
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0261 0.0821
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0424 0.1957
Echinococcus granulosus Glycosyl transferase family 35 0.0247 0.282 0.3186
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0032 0.023
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.1346 0.6406
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0055 0.005
Entamoeba histolytica glycogen phosphorylase, putative 0.0107 0.1119 0.3969
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0042 0.0042
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0251 0.0238
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.0036
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0032 0.0324
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0036
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0297 0.072
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0429 0.1039
Echinococcus granulosus zinc finger protein 0.0022 0.0085 0.0091
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0168 0.1861 0.4508
Loa Loa (eye worm) hypothetical protein 0.0036 0.0261 0.0261
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.0077
Trichomonas vaginalis glycogen phosphorylase, putative 0.0247 0.282 0.282
Echinococcus multilocularis RUN 0.002 0.0067 0.0063
Brugia malayi Cathepsin L-like precursor 0.0018 0.0036 0.0036
Onchocerca volvulus 0.0018 0.0036 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0036 0.0036
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0055 0.0056
Mycobacterium ulcerans glutaminase 0.0839 1 1
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0036 0.0062
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0036 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.094 0.0929
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0552 0.932
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0047 0.0047
Brugia malayi Cathepsin L-like precursor 0.0018 0.0036 0.0036
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0055 0.0055
Onchocerca volvulus 0.002 0.0067 0.0114
Giardia lamblia Glycogen phosphorylase 0.0247 0.282 1
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0634 0.1535
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0409 0.0378
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.0036
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.1346 0.6406
Entamoeba histolytica hypothetical protein 0.0072 0.07 0.2483
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0801 0.079
Brugia malayi hypothetical protein 0.002 0.0067 0.0067
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0036 0.0035
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0032 0.0077
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0032 0.0077
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0193 0.0467
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0409 0.0378
Loa Loa (eye worm) hypothetical protein 0.0036 0.0261 0.0261
Brugia malayi F/Y-rich N-terminus family protein 0.0025 0.0123 0.0123
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0047 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0193 0.4295
Echinococcus granulosus geminin 0.0205 0.2304 0.2602
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0067 0.1192
Schistosoma mansoni hypothetical protein 0.0035 0.0251 0.0238
Onchocerca volvulus 0.002 0.0067 0.0114
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0409 0.0409
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0251 0.4052
Toxoplasma gondii cathepsin CPL 0.0018 0.0036 0.0309
Loa Loa (eye worm) hypothetical protein 0.0036 0.0261 0.0261
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0032 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.0036
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0409 0.0378
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.07 0.0689
Plasmodium falciparum thioredoxin reductase 0.005 0.0424 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0555 0.0622
Leishmania major trypanothione reductase 0.005 0.0424 0.1027
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0193 0.3042
Schistosoma mansoni polycystin 1-related 0.002 0.0067 0.0055
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0036 0.0129
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0251 0.0251
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0409 0.1449
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0019 0.0014
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0409 0.1449
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0047 0.0047
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0036 0.0024
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0019 0.0045
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0409 0.1449
Toxoplasma gondii thioredoxin reductase 0.005 0.0424 0.7085
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0067 0.0063
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0034 0.0029
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0047 0.0055
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.0036
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0036 0.0437
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.0072 0.07 0.2483
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.1193 0.5668
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0032 0.023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0634 0.1535
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0297 0.0297
Schistosoma mansoni bromodomain containing protein 0.0066 0.0624 0.0613
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0437 0.5126 0.5126
Onchocerca volvulus 0.0018 0.0036 0.0062
Echinococcus multilocularis glycogen phosphorylase 0.0247 0.282 0.2866
Entamoeba histolytica hypothetical protein 0.0072 0.07 0.2483
Brugia malayi Glycosyl hydrolases family 31 protein 0.0176 0.1957 0.1957
Trichomonas vaginalis set domain proteins, putative 0.0498 0.5858 0.5858
Entamoeba histolytica glycogen phosphorylase, putative 0.0107 0.1119 0.3969
Plasmodium vivax vivapain-2 0.0018 0.0036 0.0309
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0036 0.0129
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0032 0.0077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0237 0.1053
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0634 0.1535
Loa Loa (eye worm) hypothetical protein 0.0036 0.0261 0.0261
Echinococcus granulosus muscleblind protein 0.0296 0.341 0.3853
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0036 0.0062
Plasmodium falciparum phd finger protein, putative 0.0035 0.0251 0.572
Loa Loa (eye worm) hypothetical protein 0.006 0.0554 0.0554
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0032 0.0077
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Echinococcus multilocularis muscleblind protein 0.0296 0.341 0.3467
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0036 0.0437
Echinococcus multilocularis cysteine protease 0.0018 0.0036 0.0032
Leishmania major cathepsin L-like protease 0.0018 0.0036 0.0088
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0078 0.0078
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0047 1
Onchocerca volvulus 0.0063 0.0591 0.1009
Brugia malayi Cathepsin L-like precursor 0.0018 0.0036 0.0036
Schistosoma mansoni ap endonuclease 0.0018 0.0047 0.0035
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0563 0.1365
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0047 0.0701
Echinococcus granulosus lysine specific demethylase 5A 0.0046 0.0384 0.0429
Schistosoma mansoni alpha-glucosidase 0.0151 0.166 0.1649
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.0036
Echinococcus multilocularis cysteine protease 0.0018 0.0036 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.0036
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0107 0.1119 0.5312
Onchocerca volvulus 0.0018 0.0036 0.0062
Schistosoma mansoni hypothetical protein 0.0019 0.0055 0.0042

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 210.01 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.8876 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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