Detailed information for compound 1558500

Basic information

Technical information
  • TDR Targets ID: 1558500
  • Name: N-[4-[2-[(4-chlorophenyl)amino]-2-oxoethyl]-1 ,3-thiazol-2-yl]-N-(3-dimethylaminopropyl)pro panamide
  • MW: 408.945 | Formula: C19H25ClN4O2S
  • H donors: 1 H acceptors: 3 LogP: 2.95 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)N(c1scc(n1)CC(=O)Nc1ccc(cc1)Cl)CCCN(C)C
  • InChi: 1S/C19H25ClN4O2S/c1-4-18(26)24(11-5-10-23(2)3)19-22-16(13-27-19)12-17(25)21-15-8-6-14(20)7-9-15/h6-9,13H,4-5,10-12H2,1-3H3,(H,21,25)
  • InChiKey: MKHLKUJXDGNBCL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[2-[(4-chlorophenyl)amino]-2-oxo-ethyl]thiazol-2-yl]-N-(3-dimethylaminopropyl)propanamide
  • N-[4-[2-[(4-chlorophenyl)amino]-2-oxoethyl]-2-thiazolyl]-N-(3-dimethylaminopropyl)propanamide
  • N-[4-[2-[(4-chlorophenyl)amino]-2-keto-ethyl]thiazol-2-yl]-N-(3-dimethylaminopropyl)propionamide
  • N-[4-[2-[(4-chlorophenyl)amino]-2-oxo-ethyl]-1,3-thiazol-2-yl]-N-(3-dimethylaminopropyl)propanamide
  • ASN 04372141

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.0693 0.1274
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0017 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0039
Schistosoma mansoni DNA polymerase IV / kappa 0.004 0.0161 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0134 0.0801 0.2581
Onchocerca volvulus 0.0048 0.0218 0.0242
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0572 0.3775 0.607
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0607 0.2738
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0162 0.0988 0.3196
Leishmania major NADH dehydrogenase, putative 0.0043 0.0183 0.0546
Onchocerca volvulus 0.0043 0.0183 0.0185
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0043 0.0183 0.0202
Mycobacterium ulcerans DNA polymerase IV 0.0154 0.0933 0.4744
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0043 0.0183 0.0202
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0162 0.0988 0.5084
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0043 0.0183 0.0336
Giardia lamblia Thioredoxin reductase 0.0043 0.0183 0.0266
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0043 0.0183 0.0336
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0198 0.0364
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0043 0.0183 0.0546
Leishmania major phosphopantetheinyl transferase-like protein 0.0046 0.0203 0.061
Brugia malayi jmjC domain containing protein 0.0018 0.0017 0.0032
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0183 0.0546
Trichomonas vaginalis rotamase, putative 0.0098 0.0556 0.0865
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0043 0.0183 0.0262
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0528 0.1351
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0607 0.1115
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0262
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0117 0.0688 0.0688
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0988 0.3196
Giardia lamblia PHD finger protein 15 0.0057 0.028 0.0528
Schistosoma mansoni disulfide oxidoreductase 0.0043 0.0183 0.0183
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0032
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0043 0.0183 0.0137
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0043 0.0183 0.0546
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0572 0.3775 0.607
Entamoeba histolytica deoxycytidyl transferase, putative 0.0128 0.0758 0.1963
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0128 0.0758 0.0837
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0103
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0127 0.0281
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0607 0.0669
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0128 0.0758 0.1394
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0043 0.0183 0.0202
Brugia malayi 6-phosphofructokinase 0.0105 0.0607 0.1115
Giardia lamblia Kinase, PLK 0.0094 0.0528 0.1201
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0177 0.0526
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0103
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0043 0.0183 0.0546
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0177 0.0526
Brugia malayi jmjC domain containing protein 0.0018 0.0017 0.0032
Trichomonas vaginalis glutamate synthase, putative 0.0043 0.0183 0.0262
Giardia lamblia DNA damage repair protein 0.004 0.0161 0.0205
Trypanosoma brucei unspecified product 0.0088 0.0489 0.1553
Treponema pallidum thioredoxin reductase (trxB) 0.0043 0.0183 0.0266
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0336 0.1049
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0021 0.0039
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0043 0.0183 0.0431
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0046 0.0203 0.061
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0058 0.0134
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0021 0.0039
Trypanosoma brucei unspecified product 0.0088 0.0489 0.1553
Schistosoma mansoni hypothetical protein 0.0332 0.2143 0.2143
Entamoeba histolytica disulphide oxidoreductase, putative 0.0043 0.0183 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0127 0.0171
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0043 0.0183 0.0997
Toxoplasma gondii selenide, water dikinase 0.0043 0.0183 0.0546
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0528 0.082
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0046 0.0204 0.0615
Toxoplasma gondii hypothetical protein 0.0048 0.0219 0.0664
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0085 0.0223
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0046 0.0203 0.061
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0988 0.3196
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Trichomonas vaginalis mercuric reductase, putative 0.0162 0.0988 0.1564
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0528 0.1681
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0162 0.0988 1
Leishmania major trypanothione reductase 0.0466 0.3056 1
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0021 0.0039
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0163 0.0997 0.0997
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0043 0.0183 0.0546
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.096 0.1004
Echinococcus granulosus geminin 0.0332 0.2143 0.2366
Brugia malayi glutathione reductase 0.0466 0.3056 0.5619
Plasmodium vivax hypothetical protein, conserved 0.0057 0.028 0.0865
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0085 0.017
Trypanosoma brucei DNA polymerase IV, putative 0.0147 0.089 0.2871
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0017 0.0019
Trypanosoma brucei DNA damage repair protein, putative 0.004 0.0161 0.0472
Onchocerca volvulus Alhambra homolog 0.0057 0.028 0.0343
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0043 0.0183 0.0266
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0187 0.1163 0.1283
Toxoplasma gondii peptidylprolyl isomerase 0.0096 0.054 0.1721
Loa Loa (eye worm) hypothetical protein 0.0065 0.0336 0.0618
Plasmodium vivax ferrodoxin reductase, putative 0.0043 0.0183 0.0546
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0127 0.036
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0023 0.0026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0127 0.0171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0198 0.0218
Trypanosoma cruzi trypanothione reductase, putative 0.0466 0.3056 1
Echinococcus multilocularis tumor protein p63 0.0328 0.2118 0.2338
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0851 0.2745
Brugia malayi Bromodomain containing protein 0.0057 0.028 0.0515
Brugia malayi jmjC domain containing protein 0.0187 0.1163 0.2138
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0127 0.036
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0021 0.0021
Trypanosoma cruzi DNA damage repair protein, putative 0.004 0.0161 0.0472
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.028 0.0865
Toxoplasma gondii ImpB/MucB/SamB family protein 0.009 0.05 0.1589
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0572 0.3775 0.607
Echinococcus granulosus nuclear factor of activated T cells 5 0.0071 0.0376 0.0415
Echinococcus granulosus intermediate filament protein 0.0026 0.0069 0.0076
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0134 0.0801 0.08
Echinococcus granulosus L aminoadipate semialdehyde 0.0163 0.0997 0.11
Loa Loa (eye worm) programmed cell death 8 0.0043 0.0183 0.0336
Plasmodium vivax glutathione reductase, putative 0.0466 0.3056 1
Brugia malayi hypothetical protein 0.0019 0.0021 0.0039
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0046 0.0203 0.1216
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0262
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0362 0.0362
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0113 0.0658 0.0727
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0134 0.0801 0.2581
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0046 0.0203 0.0257
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0043 0.0183 0.0546
Schistosoma mansoni rotamase 0.0098 0.0556 0.0556
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0162 0.0988 0.3196
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0023 0.0042
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0021 0.0021
Trypanosoma brucei DNA polymerase IV, putative 0.0154 0.0933 0.3014
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.0556 0.0865
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0127 0.036
Echinococcus granulosus jumonji domain containing protein 0.008 0.0432 0.0477
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0017 0.0019
Brugia malayi Pre-SET motif family protein 0.0818 0.5439 1
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0127 0.0233
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.028 0.0865
Leishmania major DNA polymerase kappa, putative 0.0134 0.0801 0.2581
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0019 0.0005
Trypanosoma cruzi NADH dehydrogenase, putative 0.0043 0.0183 0.0546
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0203 0.061
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0528 0.0971
Trichomonas vaginalis glutamate synthase, putative 0.0043 0.0183 0.0262
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0019 0.0005
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0021 0.0023
Trypanosoma cruzi DNA damage repair protein, putative 0.004 0.0161 0.0472
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0021 0.0023
Schistosoma mansoni sulfide quinone reductase 0.0043 0.0183 0.0183
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0262
Trypanosoma cruzi DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Mycobacterium ulcerans hypothetical protein 0.0043 0.0183 0.0137
Mycobacterium tuberculosis Probable dehydrogenase 0.1064 0.711 0.8958
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0017 0.0019
Leishmania major DNA damage repair protein, putative 0.004 0.0161 0.0472
Schistosoma mansoni transcription factor btf3 0.0035 0.0127 0.0127
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0043 0.0183 0.0546
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.003 0.0094 0.0252
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0043 0.0183 0.0137
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.003 0.0094 0.0252
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0162 0.0988 0.3196
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0607 0.0669
Leishmania major hypothetical protein, conserved 0.0043 0.0183 0.0546
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0094 0.0252
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0043 0.0183 0.0202
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0043 0.0183 0.0202
Mycobacterium tuberculosis Probable reductase 0.1064 0.711 0.8958
Brugia malayi MH2 domain containing protein 0.0234 0.1478 0.2718
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0058 0.0134
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0851 0.2745
Echinococcus granulosus lamin 0.0026 0.0069 0.0076
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.028 0.1789 0.2077
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0607 0.1413
Echinococcus multilocularis microtubule associated protein 2 0.1352 0.906 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0469 0.3073 0.3392
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.028 0.0515
Mycobacterium leprae conserved hypothetical protein 0.0046 0.0203 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0528 0.082
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0269 0.0666
Brugia malayi Thioredoxin reductase 0.0466 0.3056 0.5619
Echinococcus granulosus expressed protein 0.0371 0.2406 0.2655
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.028 0.0309
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0162 0.0988 1
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0043 0.0183 0.0546
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0198 0.0198
Trichomonas vaginalis rotamase, putative 0.0096 0.054 0.0839
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0262
Brugia malayi PXA domain containing protein 0.0019 0.0021 0.0039
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0085 0.0223
Brugia malayi AF-10 protein 0.0019 0.0019 0.0034
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0058 0.0134
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0094 0.0252
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0021 0.0023
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0177 0.0526
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0162 0.0988 0.3196
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0019 0.0005
Echinococcus multilocularis lamin dm0 0.0026 0.0069 0.0076
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.028 0.1789 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0128 0.0758 0.0758
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0019 0.0005
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0161 0.0472
Trypanosoma cruzi DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Treponema pallidum NADH oxidase 0.0162 0.0988 0.2448
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0207 0.03
Loa Loa (eye worm) hypothetical protein 0.0026 0.0069 0.0127
Echinococcus granulosus tumor protein p63 0.0328 0.2118 0.2338
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.1919 0.6258
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0607 0.156
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0043 0.0183 0.0546
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0162 0.0988 0.3196
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0244 0.0448
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0117 0.0688 0.0759
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0021 0.0021
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0043 0.0183 0.0546
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0162 0.0988 0.3196
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0023 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0528 0.0528
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0021 0.0023
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0043 0.0183 0.0262
Brugia malayi hypothetical protein 0.0019 0.0021 0.0039
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1183 0.7915 1
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0043 0.0183 0.0262
Brugia malayi 6-phosphofructokinase 0.0105 0.0607 0.1115
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0607 0.1939
Echinococcus multilocularis dna polymerase eta 0.0178 0.1097 0.1211
Loa Loa (eye worm) hypothetical protein 0.0048 0.0218 0.04
Leishmania major hypothetical protein, conserved 0.0024 0.0058 0.0134
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0043 0.0183 0.0546
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0183 0.0546
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0127 0.036
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0802 0.5334 0.5888
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0058 0.0134
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0043 0.0183 0.0202
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0607 0.156
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0607 0.1939
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0043 0.0183 0.0431
Brugia malayi jmjC domain containing protein 0.0018 0.0017 0.0032
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0043 0.0183 0.0546
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0043 0.0183 0.0546
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0021 0.0023
Echinococcus granulosus histone lysine methyltransferase setb 0.0117 0.0688 0.0759
Trypanosoma cruzi trypanothione reductase, putative 0.0162 0.0988 0.3196
Loa Loa (eye worm) hypothetical protein 0.0024 0.0058 0.0107
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0607 0.0947
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0161 0.0472
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0162 0.0988 0.5084
Trypanosoma cruzi DNA polymerase eta, putative 0.009 0.05 0.1589
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0043 0.0183 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.0533 0.1696
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0098 0.0556 0.1022
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0607 0.1115
Trypanosoma brucei DNA damage repair protein, putative 0.004 0.0161 0.0472
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0085 0.0103
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0043 0.0183 0.0137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0572 0.3775 0.607
Brugia malayi Pre-SET motif family protein 0.0117 0.0688 0.1264
Echinococcus granulosus dna polymerase eta 0.0178 0.1097 0.1211
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0085 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Leishmania major DNA polymerase eta, putative 0.009 0.05 0.1589
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0094 0.0252
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0528 0.1681
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0085 0.0223
Echinococcus multilocularis lamin 0.0026 0.0069 0.0076
Brugia malayi jmjC domain containing protein 0.0018 0.0017 0.0032
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0043 0.0183 0.0202
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0021 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0688 0.0688
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0021 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0046 0.0203 0.0025
Brugia malayi hypothetical protein 0.0024 0.0058 0.0107
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0162 0.0988 0.1091
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0021 0.0023
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0043 0.0183 0.0137
Loa Loa (eye worm) thioredoxin reductase 0.0466 0.3056 0.5619
Echinococcus multilocularis peregrin 0.0057 0.028 0.0309
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0161 0.0472
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0198 0.0218
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0607 0.1939
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0162 0.0988 0.3196
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0269 0.0111
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0048 0.0048
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0017 0.0019
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0262
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0103
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0362 0.0362
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0069 0.0127
Echinococcus granulosus dna polymerase kappa 0.0154 0.0933 0.103
Trypanosoma brucei polo-like protein kinase 0.0094 0.0528 0.1681
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0607 0.156
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0017 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0336 0.1049
Trypanosoma brucei DNA polymerase IV, putative 0.0154 0.0933 0.3014
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0048 0.0088
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0162 0.0988 0.3196
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0183 0.0546
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0039
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0096 0.054 0.1383
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0017 0.0017
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0096 0.054 0.1721
Schistosoma mansoni terminal deoxycytidyl transferase 0.0128 0.0758 0.0758
Echinococcus multilocularis expressed protein 0.0371 0.2406 0.2655
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0021 0.0023
Brugia malayi glutamate synthase 0.0043 0.0183 0.0336
Mycobacterium ulcerans hypothetical protein 0.0157 0.096 0.4907
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0607 0.1115
Onchocerca volvulus 0.0117 0.0688 0.1008
Schistosoma mansoni glutamate synthase 0.0043 0.0183 0.0183
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0023 0.0023
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0021 0.0023
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0183 0.0546
Mycobacterium ulcerans dehydrogenase 0.0043 0.0183 0.0137
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0021 0.0023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0198 0.0218
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0128 0.0758 0.0837
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.1919 0.6258
Trypanosoma cruzi DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.028 0.1789 0.2077
Schistosoma mansoni hypothetical protein 0.0019 0.0019 0.0019
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0021 0.0023
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0119 0.0697 0.1282
Brugia malayi beta-NAC-like protein 0.0035 0.0127 0.0233
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1064 0.711 0.8958
Mycobacterium ulcerans DNA polymerase IV 0.0154 0.0933 0.4744
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0058 0.0134
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0023 0.0042
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0021 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0023 0.0023
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0085 0.0223
Brugia malayi jmjC domain containing protein 0.0069 0.0362 0.0665
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1183 0.7915 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0161 0.0472
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0163 0.0997 0.1832
Trypanosoma brucei chrX additional, unordered contigs 0.004 0.0161 0.0472
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0017 0.0017
Schistosoma mansoni glutamate synthase 0.0043 0.0183 0.0183
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0043 0.0183 0.0997
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0528 0.082
Plasmodium falciparum phd finger protein, putative 0.0057 0.028 0.0865
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0162 0.0988 0.3196
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0163 0.0997 0.1832
Loa Loa (eye worm) hypothetical protein 0.0117 0.0688 0.1264
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0198 0.0218
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0154 0.0933 0.1475
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0162 0.0988 0.1817
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0198 0.0198
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0021 0.0023
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0528 0.1681
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0528 0.082
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0607 0.0548
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0046 0.0203 0.0319
Mycobacterium tuberculosis Conserved hypothetical protein 0.0128 0.0758 0.0744
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0039
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0607 0.0947
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0117 0.0688 0.0759
Plasmodium vivax DNA repair protein REV1, putative 0.004 0.0161 0.0472
Trypanosoma brucei unspecified product 0.0147 0.089 0.2871
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0988 0.3196
Entamoeba histolytica hypothetical protein 0.0046 0.0203 0.0484
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0362 0.0399
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0988 0.3196
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0043 0.0183 0.0431
Giardia lamblia Glutamate synthase 0.0043 0.0183 0.0266
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0607 0.0947
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0162 0.0988 1
Toxoplasma gondii thioredoxin reductase 0.0466 0.3056 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0162 0.0988 0.3196
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0572 0.3775 1
Onchocerca volvulus 0.0163 0.0997 0.1511
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0203 0.061
Brugia malayi ImpB/MucB/SamB family protein 0.0178 0.1097 0.2018
Trypanosoma brucei DNA polymerase eta, putative 0.0178 0.1097 0.3554
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0043 0.0183 0.0202
Schistosoma mansoni hypothetical protein 0.0057 0.028 0.028
Entamoeba histolytica thioredoxin reductase, putative 0.0043 0.0183 0.0431
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1064 0.711 0.8958
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0162 0.0988 0.1091
Echinococcus granulosus transcription factor btf3 0.0035 0.0127 0.014
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0043 0.0183 0.0546
Trypanosoma cruzi NADH dehydrogenase, putative 0.0043 0.0183 0.0546
Brugia malayi ImpB/MucB/SamB family protein 0.0128 0.0758 0.1394
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0098 0.0556 0.1022
Chlamydia trachomatis thioredoxin reductase 0.0043 0.0183 0.1085
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0607 0.0607
Schistosoma mansoni lamin 0.0026 0.0069 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0528 0.0748
Leishmania major DNA polymerase kappa, putative 0.004 0.0161 0.0472
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0039
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0085 0.0223
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0572 0.3775 0.607
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0039
Brugia malayi polk-prov protein 0.0065 0.0336 0.0618
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0043 0.0183 0.0546
Schistosoma mansoni hypothetical protein 0.0332 0.2143 0.2143
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0043 0.0183 0.0997
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0058 0.0134
Brugia malayi PHD-finger family protein 0.0019 0.0019 0.0034
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0851 0.2745
Treponema pallidum fructose-bisphosphate aldolase 0.0572 0.3775 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0178 0.1097 0.3554
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0269 0.0297
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0269 0.0297
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0021 0.0023
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0021 0.0021
Echinococcus granulosus expressed protein 0.0098 0.0556 0.0613
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0121
Trichomonas vaginalis set domain proteins, putative 0.0931 0.6205 1
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0207 0.03
Plasmodium falciparum DNA repair protein REV1, putative 0.004 0.0161 0.0472
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0021 0.0023
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0017 0.0019
Mycobacterium ulcerans ferredoxin reductase 0.0043 0.0183 0.0137
Trichomonas vaginalis apoptosis inducing factor, putative 0.0043 0.0183 0.0262
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0162 0.0988 0.5084
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0572 0.3775 0.607
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0269 0.0495
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0187 0.1163 0.1283
Entamoeba histolytica hypothetical protein 0.0035 0.0127 0.0281
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0572 0.3775 0.607
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0117 0.0688 0.2206
Echinococcus granulosus phd:f box containing protein 0.0018 0.0017 0.0019
Mycobacterium ulcerans glutamate synthase subunit beta 0.0043 0.0183 0.0137
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0069 0.0127
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.1919 0.6258
Leishmania major hypothetical protein, conserved 0.0043 0.0183 0.0546
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0162 0.0988 0.0988
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0046 0.0203 0.0257
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0043 0.0183 0.0137
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0043 0.0183 0.0137
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0162 0.0988 0.3196
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.1919 0.6258
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0177 0.0526
Brugia malayi intermediate filament protein 0.0026 0.0069 0.0127
Echinococcus multilocularis thioredoxin glutathione reductase 0.0469 0.3073 0.3392
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0161 0.0472
Treponema pallidum oxidoreductase 0.0043 0.0183 0.0266
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0021 0.0021
Mycobacterium tuberculosis Probable oxidoreductase 0.1183 0.7915 1
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0085 0.0223
Leishmania major basic transcription factor 3a, putative 0.0035 0.0127 0.036
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0528 0.082
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1183 0.7915 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0043 0.0183 0.0546
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.1478 0.2718
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0021 0.0021
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0017 0.0019
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0017 0.0032
Schistosoma mansoni hypothetical protein 0.0043 0.0183 0.0183
Plasmodium falciparum ferrodoxin reductase-like protein 0.0043 0.0183 0.0546
Loa Loa (eye worm) glutathione reductase 0.0466 0.3056 0.5619
Brugia malayi PXA domain containing protein 0.0019 0.0021 0.0039
Echinococcus multilocularis glutamate synthase 0.0043 0.0183 0.0202
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0183 0.0546
Giardia lamblia Fructose-bisphosphate aldolase 0.0572 0.3775 1
Schistosoma mansoni lamin 0.0026 0.0069 0.0069
Echinococcus granulosus lamin dm0 0.0026 0.0069 0.0076
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0096 0.054 0.1721
Trichomonas vaginalis DNA polymerase eta, putative 0.0154 0.0933 0.1475
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0162 0.0988 0.3196
Plasmodium falciparum thioredoxin reductase 0.0162 0.0988 0.3196
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0988 0.3196
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0043 0.0183 0.0546
Brugia malayi PHD-finger family protein 0.0057 0.028 0.0515
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0269 0.0829
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0262
Mycobacterium ulcerans NADH dehydrogenase 0.0043 0.0183 0.0137
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0183 0.0546
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0017 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0183 0.0546
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0269 0.0666
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0528 0.0583
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0021 0.0023
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0021 0.0021
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0017 0.0032
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0607 0.0947
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0021 0.0039
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0019 0.0005
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0021 0.0023
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0021 0.0039
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0019 0.0005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0183 0.0336
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0043 0.0183 0.0431
Schistosoma mansoni kinase 0.0048 0.0215 0.0215
Mycobacterium ulcerans monoxygenase 0.0043 0.0183 0.0137
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0162 0.0988 0.1042
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0034
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0162 0.0988 0.3196
Trypanosoma brucei trypanothione reductase 0.0466 0.3056 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0362 0.0665
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0021 0.0021
Echinococcus granulosus Solute carrier family 22 5 0.1003 0.6697 0.7392
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0127 0.036
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0103
Echinococcus granulosus peregrin 0.0057 0.028 0.0309
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0818 0.5439 1
Trichomonas vaginalis glutathione reductase, putative 0.0162 0.0988 0.1564
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0528 0.082
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1064 0.711 0.8958
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0043 0.0183 0.0202
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0528 0.082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0688 0.0688
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0203 0.061
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0023 0.0026
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0043 0.0183 0.0431
Echinococcus granulosus glutamate synthase 0.0043 0.0183 0.0202
Schistosoma mansoni microtubule-associated protein tau 0.1352 0.906 0.906
Echinococcus multilocularis geminin 0.0332 0.2143 0.2366
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0043 0.0183 0.0202
Trypanosoma brucei NADH dehydrogenase 0.0043 0.0183 0.0546
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0103
Schistosoma mansoni DNA polymerase eta 0.0178 0.1097 0.1097
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.028 0.028
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0362 0.0399
Leishmania major hypothetical protein, conserved 0.0043 0.0183 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0933 0.3014
Plasmodium vivax thioredoxin reductase, putative 0.0466 0.3056 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0162 0.0988 0.2448
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0043 0.0183 0.0137
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0023 0.0023
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0162 0.0988 0.3196
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0069 0.0127
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0607 0.0548
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0239 0.0731
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0218 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.0533 0.1696
Echinococcus multilocularis expressed protein 0.0098 0.0556 0.0613
Plasmodium falciparum thioredoxin reductase 0.0466 0.3056 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0017 0.0019
Echinococcus multilocularis L aminoadipate semialdehyde 0.0163 0.0997 0.11
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0688 0.0688
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0127 0.036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0162 0.0988 0.3196
Onchocerca volvulus 0.0931 0.6206 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1064 0.711 0.8958
Toxoplasma gondii NADPH-glutathione reductase 0.0162 0.0988 0.3196
Giardia lamblia DINP protein human, muc B family 0.0134 0.0801 0.1942
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0046 0.0203 0.1302
Loa Loa (eye worm) hypothetical protein 0.0098 0.0557 0.1024
Echinococcus multilocularis jumonji domain containing protein 0.008 0.0432 0.0477
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.1478 0.2718
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0466 0.3056 0.3716
Loa Loa (eye worm) hypothetical protein 0.0178 0.1097 0.2018
Plasmodium vivax SET domain protein, putative 0.0117 0.0688 0.2206
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0021 0.0023
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0162 0.0988 0.3196
Trypanosoma brucei DNA polymerase kappa, putative 0.0094 0.0533 0.1696
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0119 0.0697 0.1282
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0127 0.0171
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0043 0.0183 0.0262
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0198 0.0364
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0572 0.3775 1
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0058 0.0134
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0096 0.054 0.1721
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1064 0.711 0.8958
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0021 0.0039
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.028 0.0309
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0528 0.0583
Loa Loa (eye worm) hypothetical protein 0.0057 0.028 0.0515
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0607 0.0607
Echinococcus multilocularis musashi 0.0026 0.0069 0.0076
Echinococcus multilocularis dna polymerase kappa 0.0154 0.0933 0.103
Echinococcus multilocularis transcription factor btf3 0.0035 0.0127 0.014
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0096 0.054 0.1721
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0021 0.0021
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0528 0.0971
Schistosoma mansoni glutamate synthase 0.0043 0.0183 0.0183
Schistosoma mansoni jumonji domain containing protein 0.0149 0.0902 0.0902
Schistosoma mansoni sulfide quinone reductase 0.0043 0.0183 0.0183
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0198 0.0198
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0071 0.0376 0.0415
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0269 0.0269
Plasmodium falciparum glutathione reductase 0.0162 0.0988 0.3196
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0572 0.3775 0.607
Schistosoma mansoni intermediate filament proteins 0.0026 0.0069 0.0069
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0017 0.0017
Plasmodium falciparum glutathione reductase 0.0466 0.3056 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0043 0.0183 0.0202
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0021 0.0039
Echinococcus granulosus microtubule associated protein 2 0.1352 0.906 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0021 0.0039
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0043 0.0183 0.0336
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0043 0.0183 0.0202
Brugia malayi phosphofructokinase 0.0105 0.0607 0.1115
Leishmania major DNA polymerase eta, putative 0.0178 0.1097 0.3554
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0085 0.0103

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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