Detailed information for compound 1572126

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 812.917 | Formula: C31H48N12O10S2
  • H donors: 11 H acceptors: 9 LogP: -5.36 Rotable bonds: 23
    Rule of 5 violations (Lipinski): 3
  • SMILES: COC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)CN1CCNCCNCCNCC1)CSCc1c[nH]c(=O)[nH]c1=O)CSCc1c[nH]c(=O)[nH]c1=O
  • InChi: 1S/C31H48N12O10S2/c1-53-29(50)22(18-55-16-20-11-38-31(52)42-27(20)48)40-24(45)13-36-28(49)21(17-54-15-19-10-37-30(51)41-26(19)47)39-23(44)12-35-25(46)14-43-8-6-33-4-2-32-3-5-34-7-9-43/h10-11,21-22,32-34H,2-9,12-18H2,1H3,(H,35,46)(H,36,49)(H,39,44)(H,40,45)(H2,37,41,47,51)(H2,38,42,48,52)/t21-,22-/m0/s1
  • InChiKey: OLHJHBUSOSGYOU-VXKWHMMOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dna polymerase eta 0.0181 0.1101 0.1204
Schistosoma mansoni kinase 0.0049 0.0217 0.02
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0059 0.0137
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.0603 0.0651
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0603 0.108
Toxoplasma gondii NADPH-glutathione reductase 0.0164 0.0989 0.3196
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0531 0.0824
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0022 0.0041
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0022 0.0005
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0043 0.0183 0.027
Mycobacterium tuberculosis Probable oxidoreductase 0.1199 0.7915 1
Leishmania major hypothetical protein, conserved 0.0043 0.0183 0.0546
Trichomonas vaginalis apoptosis inducing factor, putative 0.0043 0.0183 0.0261
Brugia malayi PHD-finger family protein 0.0019 0.0019 0.0035
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0242 0.0414
Loa Loa (eye worm) hypothetical protein 0.0119 0.0688 0.1236
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0022 0.0005
Toxoplasma gondii selenide, water dikinase 0.0043 0.0183 0.0546
Leishmania major mitochondrial DNA polymerase beta 0.0301 0.1908 0.6222
Echinococcus granulosus tumor protein p63 0.0334 0.2128 0.2347
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.0603 0.0651
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0164 0.0989 0.3196
Loa Loa (eye worm) hypothetical protein 0.0164 0.0991 0.1796
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0201 0.0605
Echinococcus granulosus lamin dm0 0.0026 0.0069 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0156 0.0936 0.3021
Leishmania major DNA damage repair protein, putative 0.004 0.0162 0.0474
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0022 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0156 0.0936 0.3021
Echinococcus granulosus intermediate filament protein 0.0026 0.0069 0.0057
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0019 0.0005
Schistosoma mansoni terminal deoxycytidyl transferase 0.013 0.076 0.0743
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0282 0.1779 0.2063
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0084 0.0101
Leishmania major hypothetical protein, conserved 0.0025 0.0059 0.0137
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.003 0.0094 0.0251
Brugia malayi jmjC domain containing protein 0.0019 0.0018 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0176 0.0521
Trichomonas vaginalis mercuric reductase, putative 0.0164 0.0989 0.1564
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0022 0.0005
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0043 0.0183 0.0184
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0164 0.0989 0.3196
Trichomonas vaginalis rotamase, putative 0.0097 0.0539 0.0837
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0043 0.0183 0.0337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0197 0.0179
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0531 0.0515
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0046 0.0201 0.0319
Brugia malayi Bromodomain containing protein 0.0058 0.028 0.0515
Brugia malayi glutathione reductase 0.0473 0.3056 0.5622
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0267 0.0654
Echinococcus granulosus expressed protein 0.0377 0.2418 0.2669
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0282 0.1779 0.2063
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.028 0.0292
Schistosoma mansoni microtubule-associated protein tau 0.1362 0.901 0.9008
Loa Loa (eye worm) phosphofructokinase 0.0106 0.0603 0.108
Echinococcus multilocularis thioredoxin glutathione reductase 0.0475 0.3073 0.3398
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0059 0.0137
Schistosoma mansoni intermediate filament proteins 0.0026 0.0069 0.0051
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0846 0.2728
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1078 0.711 0.8958
Entamoeba histolytica thioredoxin reductase, putative 0.0043 0.0183 0.0432
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0043 0.0183 0.0261
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.147 0.268
Echinococcus granulosus L aminoadipate semialdehyde 0.0164 0.0991 0.1082
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.0603 0.2729
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0094 0.0251
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0043 0.0183 0.0184
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0094 0.0251
Entamoeba histolytica hypothetical protein 0.0035 0.0126 0.0278
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0043 0.0183 0.0546
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0094 0.0251
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0043 0.0183 0.0261
Echinococcus multilocularis expressed protein 0.0377 0.2418 0.2669
Toxoplasma gondii peptidylprolyl isomerase 0.0097 0.0539 0.1716
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.013 0.076 0.0825
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0019 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0156 0.0936 0.3021
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0954 0.0997
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0043 0.0183 0.0546
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.0603 0.0543
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0183 0.0546
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0097 0.0539 0.1716
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0022 0.0008
Plasmodium falciparum glutathione reductase 0.0164 0.0989 0.3196
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0156 0.0936 0.1478
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0337 0.1053
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0048 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0531 0.0824
Echinococcus granulosus lysine specific demethylase 5A 0.007 0.0362 0.0383
Trypanosoma cruzi DNA polymerase kappa, putative 0.0156 0.0936 0.3021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0069 0.0094
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.0603 0.1926
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0048 0.0031
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0043 0.0183 0.0546
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0084 0.0101
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0197 0.0199
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0603 0.094
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0164 0.0989 0.5116
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0267 0.0492
Brugia malayi Thioredoxin reductase 0.0473 0.3056 0.5622
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0022 0.0005
Giardia lamblia NADH oxidase lateral transfer candidate 0.0164 0.0989 0.2465
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0183 0.0546
Plasmodium falciparum DNA repair protein REV1, putative 0.004 0.0162 0.0474
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.028 0.0292
Trypanosoma brucei DNA polymerase kappa, putative 0.0156 0.0936 0.3021
Mycobacterium leprae conserved hypothetical protein 0.0046 0.0201 0.0023
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0059 0.0137
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0022 0.0005
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0022 0.0005
Echinococcus granulosus histone lysine methyltransferase setb 0.0119 0.0688 0.0745
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0043 0.0183 0.0184
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.003 0.0094 0.0251
Brugia malayi intermediate filament protein 0.0026 0.0069 0.0126
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0531 0.1691
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0084 0.0167
Leishmania major DNA polymerase eta, putative 0.0181 0.1101 0.3564
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0084 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0156 0.0936 0.3021
Leishmania major DNA polymerase eta, putative 0.0091 0.0502 0.1596
Trypanosoma cruzi DNA polymerase eta, putative 0.0091 0.0502 0.1596
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0531 0.0824
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0261
Schistosoma mansoni rotamase 0.0099 0.0555 0.0538
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0164 0.0989 0.108
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.0688 0.0671
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0577 0.3754 0.6038
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0043 0.0183 0.0337
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0084 0.0101
Trypanosoma brucei DNA damage repair protein, putative 0.004 0.0162 0.0474
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0603 0.1556
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.0688 0.0671
Trichomonas vaginalis glutathione reductase, putative 0.0164 0.0989 0.1564
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0059 0.0137
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0603 0.1926
Plasmodium vivax DNA repair protein REV1, putative 0.004 0.0162 0.0474
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0022 0.0005
Echinococcus granulosus glutamate synthase 0.0043 0.0183 0.0184
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0043 0.0183 0.0261
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0603 0.0586
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0603 0.1556
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0043 0.0183 0.0432
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0126 0.0168
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0809 0.5306 0.5881
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0059 0.0137
Mycobacterium ulcerans monoxygenase 0.0043 0.0183 0.0135
Loa Loa (eye worm) programmed cell death 8 0.0043 0.0183 0.0306
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0043 0.0183 0.0546
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0164 0.0991 0.0975
Plasmodium vivax hypothetical protein, conserved 0.0058 0.028 0.0864
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0084 0.0101
Mycobacterium ulcerans hypothetical protein 0.0159 0.0954 0.4902
Schistosoma mansoni sulfide quinone reductase 0.0043 0.0183 0.0166
Toxoplasma gondii thioredoxin reductase 0.0473 0.3056 1
Echinococcus multilocularis geminin 0.0334 0.2131 0.235
Trypanosoma brucei DNA polymerase IV, putative 0.0156 0.0936 0.3021
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0164 0.0989 1
Leishmania major trypanothione reductase 0.0473 0.3056 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0008
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0164 0.0989 0.3196
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0531 0.0754
Schistosoma mansoni glutamate synthase 0.0043 0.0183 0.0166
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0043 0.0183 0.0184
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0164 0.0989 0.3196
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0084 0.022
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0046 0.0201 0.0246
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0209 0.0302
Giardia lamblia Kinase, PLK 0.0095 0.0531 0.1219
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.022 0.0202
Trypanosoma brucei unspecified product 0.0089 0.049 0.1556
Brugia malayi jmjC domain containing protein 0.0019 0.0018 0.0032
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0261
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0126 0.0356
Schistosoma mansoni hypothetical protein 0.0334 0.2131 0.2117
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0059 0.0137
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0043 0.0183 0.0546
Brugia malayi jmjC domain containing protein 0.0019 0.0018 0.0032
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0046 0.0201 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0337 0.1053
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0043 0.0183 0.0546
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0531 0.0948
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0043 0.0183 0.0546
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0176 0.0521
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.013 0.076 0.0825
Brugia malayi phosphofructokinase 0.0106 0.0603 0.1109
Brugia malayi beta-NAC-like protein 0.0035 0.0126 0.0231
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0603 0.094
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0176 0.0521
Trypanosoma cruzi DNA damage repair protein, putative 0.004 0.0162 0.0474
Plasmodium falciparum ferrodoxin reductase-like protein 0.0043 0.0183 0.0546
Trypanosoma brucei unspecified product 0.0089 0.049 0.1556
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0043 0.0183 0.0184
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0084 0.022
Giardia lamblia Thioredoxin reductase 0.0043 0.0183 0.027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0577 0.3754 0.6038
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0084 0.022
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.013 0.076 0.0743
Mycobacterium tuberculosis Conserved hypothetical protein 0.013 0.076 0.0745
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0603 0.1926
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0022 0.0041
Giardia lamblia Glutamate synthase 0.0043 0.0183 0.027
Mycobacterium ulcerans NADH dehydrogenase 0.0043 0.0183 0.0135
Plasmodium vivax SET domain protein, putative 0.0119 0.0688 0.2205
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0022 0.0005
Schistosoma mansoni sulfide quinone reductase 0.0043 0.0183 0.0166
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0164 0.0989 0.1042
Schistosoma mansoni hypothetical protein 0.0058 0.028 0.0263
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0043 0.0183 0.0261
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0099 0.0555 0.0991
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0043 0.0183 0.0432
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0531 0.0824
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0046 0.0201 0.1202
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0043 0.0183 0.0184
Trypanosoma brucei NADH dehydrogenase 0.0043 0.0183 0.0546
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0043 0.0183 0.0184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0197 0.0179
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0043 0.0183 0.0135
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0043 0.0183 0.0546
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0164 0.0991 0.1823
Brugia malayi 6-phosphofructokinase 0.0106 0.0603 0.1109
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0164 0.0989 0.1819
Plasmodium vivax ferrodoxin reductase, putative 0.0043 0.0183 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.0156 0.0936 0.3021
Leishmania major NADH dehydrogenase, putative 0.0043 0.0183 0.0546
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0043 0.0183 0.0546
Loa Loa (eye worm) jmjC domain-containing protein 0.012 0.0693 0.1247
Leishmania major DNA polymerase kappa, putative 0.004 0.0162 0.0474
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0019 0.0005
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0136 0.0803 0.0802
Loa Loa (eye worm) hypothetical protein 0.0049 0.022 0.0373
Giardia lamblia Fructose-bisphosphate aldolase 0.0577 0.3754 1
Schistosoma mansoni glutamate synthase 0.0043 0.0183 0.0166
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0022 0.0005
Schistosoma mansoni DNA polymerase IV / kappa 0.004 0.0162 0.0144
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0043 0.0183 0.0546
Trypanosoma cruzi DNA polymerase kappa, putative 0.0156 0.0936 0.3021
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0261
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1078 0.711 0.8958
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0022 0.0041
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0043 0.0183 0.0135
Chlamydia trachomatis thioredoxin reductase 0.0043 0.0183 0.1095
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0046 0.0201 0.0605
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0531 0.0572
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0024 0.0007
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0162 0.0474
Brugia malayi AF-10 protein 0.0019 0.0019 0.0035
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0126 0.0356
Leishmania major DNA polymerase kappa, putative 0.0136 0.0803 0.2586
Plasmodium falciparum phd finger protein, putative 0.0058 0.028 0.0864
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0432 0.0461
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0828 0.5436 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0022 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0555 0.0862
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0164 0.0989 0.3196
Echinococcus granulosus expressed protein 0.0099 0.0555 0.0597
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0126 0.02
Echinococcus multilocularis dna polymerase kappa 0.0156 0.0936 0.1021
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0114 0.0658 0.0713
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0136 0.0803 0.2586
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0043 0.0183 0.0546
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0362 0.0635
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0183 0.0546
Leishmania major phosphopantetheinyl transferase-like protein 0.0046 0.0201 0.0605
Plasmodium falciparum thioredoxin reductase 0.0473 0.3056 1
Mycobacterium ulcerans dehydrogenase 0.0043 0.0183 0.0135
Entamoeba histolytica hypothetical protein 0.0046 0.0201 0.048
Brugia malayi jmjC domain containing protein 0.0019 0.0018 0.0032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0164 0.0989 0.3196
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0374 0.0396
Trypanosoma brucei DNA polymerase kappa, putative 0.0136 0.0803 0.2586
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0069 0.0094
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.028 0.0864
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0091 0.0502 0.1596
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0577 0.3754 0.6038
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.019 0.1163 0.1273
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0126 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0156 0.0936 0.3021
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0022 0.0005
Giardia lamblia DNA damage repair protein 0.004 0.0162 0.021
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0473 0.3056 0.3716
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0197 0.0199
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0126 0.0356
Trypanosoma brucei DNA polymerase kappa, putative 0.0156 0.0936 0.3021
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0022 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0846 0.2728
Brugia malayi PHD-finger family protein 0.0058 0.028 0.0515
Schistosoma mansoni hypothetical protein 0.0334 0.2131 0.2117
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0126 0.0278
Schistosoma mansoni disulfide oxidoreductase 0.0043 0.0183 0.0166
Trypanosoma cruzi NADH dehydrogenase, putative 0.0043 0.0183 0.0546
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.019 0.1163 0.1273
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0097 0.0539 0.1716
Echinococcus multilocularis peregrin 0.0058 0.028 0.0292
Brugia malayi polk-prov protein 0.0067 0.0337 0.0621
Trypanosoma brucei DNA polymerase IV, putative 0.0149 0.0892 0.2877
Trypanosoma brucei chrX additional, unordered contigs 0.004 0.0162 0.0474
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.028 0.0263
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0362 0.0345
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0043 0.0183 0.1002
Echinococcus multilocularis tumor protein p63 0.0334 0.2128 0.2347
Echinococcus granulosus microtubule associated protein 2 0.1362 0.901 1
Trypanosoma brucei DNA polymerase eta, putative 0.0181 0.1101 0.3564
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0043 0.0183 0.0432
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0084 0.022
Entamoeba histolytica disulphide oxidoreductase, putative 0.0043 0.0183 0.0432
Loa Loa (eye worm) hypothetical protein 0.0043 0.0183 0.0306
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0534 0.17
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0119 0.0688 0.0745
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0531 0.0572
Mycobacterium tuberculosis Probable dehydrogenase 0.1078 0.711 0.8958
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0043 0.0183 0.0432
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0047 0.0205 0.0617
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0022 0.0005
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.028 0.0864
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0084 0.0101
Brugia malayi Pre-SET motif family protein 0.0828 0.5436 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0164 0.0989 0.108
Trypanosoma brucei trypanothione reductase 0.0473 0.3056 1
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.0362 0.0383
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0007
Echinococcus granulosus Solute carrier family 22 5 0.1011 0.6659 0.7385
Schistosoma mansoni transcription factor btf3 0.0035 0.0126 0.0108
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0008
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0164 0.0989 1
Onchocerca volvulus 0.0164 0.0991 0.1503
Trichomonas vaginalis glutamate synthase, putative 0.0043 0.0183 0.0261
Trypanosoma cruzi NADH dehydrogenase, putative 0.0043 0.0183 0.0546
Onchocerca volvulus 0.0049 0.022 0.0246
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0183 0.0546
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0022 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0008
Brugia malayi PXA domain containing protein 0.0019 0.0022 0.0041
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0024 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0008
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0022 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0534 0.17
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0022 0.0005
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0267 0.0822
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0603 0.108
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0022 0.0041
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0183 0.0546
Mycobacterium ulcerans hypothetical protein 0.0043 0.0183 0.0135
Loa Loa (eye worm) hypothetical protein 0.0058 0.028 0.0485
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0267 0.025
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0043 0.0183 0.0184
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0043 0.0183 0.0135
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0261
Trypanosoma brucei DNA polymerase IV, putative 0.0156 0.0936 0.3021
Plasmodium falciparum thioredoxin reductase 0.0164 0.0989 0.3196
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0164 0.0989 0.3196
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0164 0.0989 0.3196
Leishmania major hypothetical protein, conserved 0.0043 0.0183 0.0546
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0577 0.3754 0.6038
Plasmodium falciparum glutathione reductase 0.0473 0.3056 1
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0022 0.0008
Leishmania major hypothetical protein, conserved 0.0043 0.0183 0.0546
Echinococcus multilocularis musashi 0.0026 0.0069 0.0057
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0097 0.0539 0.1716
Schistosoma mansoni lamin 0.0026 0.0069 0.0051
Brugia malayi glutamate synthase 0.0043 0.0183 0.0337
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0043 0.0183 0.0184
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.147 0.268
Echinococcus multilocularis glutamate synthase 0.0043 0.0183 0.0184
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0022 0.0005
Schistosoma mansoni hypothetical protein 0.0043 0.0183 0.0166
Echinococcus multilocularis microtubule associated protein 2 0.1362 0.901 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0022 0.0041
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0084 0.0101
Brugia malayi ImpB/MucB/SamB family protein 0.0181 0.1101 0.2024
Treponema pallidum thioredoxin reductase (trxB) 0.0043 0.0183 0.027
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0603 0.1556
Plasmodium vivax thioredoxin reductase, putative 0.0473 0.3056 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0043 0.0183 0.0337
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0008
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0374 0.0396
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0267 0.0278
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0164 0.0989 0.3196
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0577 0.3754 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0069 0.0094
Schistosoma mansoni jumonji domain containing protein 0.0151 0.0901 0.0886
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0043 0.0183 0.0546
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0531 0.1691
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0043 0.0183 0.0135
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0197 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0126 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0156 0.0936 0.3021
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0097 0.0539 0.1385
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0022 0.0005
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.028 0.0485
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0531 0.0824
Echinococcus granulosus lamin 0.0026 0.0069 0.0057
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0603 0.094
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1078 0.711 0.8958
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0097 0.0539 0.1716
Echinococcus granulosus peregrin 0.0058 0.028 0.0292
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0022 0.0008
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0577 0.3754 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0197 0.0331
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0077
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.012 0.0698 0.1283
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0531 0.0824
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0043 0.0183 0.0135
Echinococcus multilocularis transcription factor btf3 0.0035 0.0126 0.012
Echinococcus multilocularis L aminoadipate semialdehyde 0.0164 0.0991 0.1082
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0119 0.0688 0.0671
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0022 0.0005
Loa Loa (eye worm) thioredoxin reductase 0.0473 0.3056 0.5608
Loa Loa (eye worm) hypothetical protein 0.0181 0.1101 0.1999
Giardia lamblia DINP protein human, muc B family 0.0136 0.0803 0.1959
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0046 0.0201 0.0605
Brugia malayi MH2 domain containing protein 0.0236 0.147 0.2703
Echinococcus multilocularis expressed protein 0.0099 0.0555 0.0597
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0432 0.0461
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0126 0.0356
Treponema pallidum NADH oxidase 0.0164 0.0989 0.2465
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0164 0.0989 0.3196
Trichomonas vaginalis set domain proteins, putative 0.0943 0.6202 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1078 0.711 0.8958
Trypanosoma cruzi trypanothione reductase, putative 0.0164 0.0989 0.3196
Brugia malayi hypothetical protein 0.0019 0.0022 0.0041
Brugia malayi Pre-SET motif family protein 0.0119 0.0688 0.1265
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0164 0.0989 0.3196
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0022 0.0005
Trichomonas vaginalis rotamase, putative 0.0099 0.0555 0.0862
Trypanosoma cruzi trypanothione reductase, putative 0.0473 0.3056 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0531 0.0824
Toxoplasma gondii hypothetical protein 0.0049 0.0218 0.0658
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0088
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0238 0.0725
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0603 0.0586
Plasmodium vivax glutathione reductase, putative 0.0473 0.3056 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0164 0.0989 0.3196
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0043 0.0183 0.0546
Echinococcus granulosus dna polymerase kappa 0.0156 0.0936 0.1021
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0043 0.0183 0.0546
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0043 0.0183 0.1002
Echinococcus multilocularis dna polymerase eta 0.0181 0.1101 0.1204
Giardia lamblia PHD finger protein 15 0.0058 0.028 0.0534
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1078 0.711 0.8958
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0261
Treponema pallidum fructose-bisphosphate aldolase 0.0577 0.3754 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0164 0.0989 0.3196
Trypanosoma cruzi DNA polymerase eta, putative 0.0181 0.1101 0.3564
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0201 0.0605
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0164 0.0989 0.5116
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0043 0.0183 0.0184
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0043 0.0183 0.0306
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0603 0.094
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0164 0.0989 0.3196
Loa Loa (eye worm) glutathione reductase 0.0473 0.3056 0.5608
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0164 0.0989 0.3196
Trypanosoma brucei unspecified product 0.0149 0.0892 0.2877
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0162 0.0474
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.0688 0.0671
Brugia malayi jmjC domain containing protein 0.007 0.0362 0.0665
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0164 0.0989 0.0973
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0046 0.0201 0.0246
Brugia malayi ImpB/MucB/SamB family protein 0.013 0.076 0.1397
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0003
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.0603 0.0543
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.0603 0.1413
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0046 0.0201 0.1294
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0531 0.1691
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0531 0.0978
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0164 0.0989 0.3196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0197 0.0179
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0197 0.0362
Trypanosoma brucei DNA polymerase kappa, putative 0.0156 0.0936 0.3021
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0022 0.0005
Onchocerca volvulus Alhambra homolog 0.0058 0.028 0.0345
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0164 0.0989 0.3196
Onchocerca volvulus 0.0119 0.0688 0.1009
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0164 0.0989 0.5116
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0183 0.0546
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0162 0.0474
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0043 0.0183 0.0546
Trypanosoma brucei polo-like protein kinase 0.0095 0.0531 0.1691
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0024 0.0044
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0084 0.022
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1199 0.7915 1
Trypanosoma brucei DNA damage repair protein, putative 0.004 0.0162 0.0474
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0164 0.0989 0.3196
Schistosoma mansoni jumonji/arid domain-containing protein 0.007 0.0362 0.0345
Brugia malayi hypothetical protein 0.0019 0.0022 0.0041
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0022 0.0005
Mycobacterium ulcerans DNA polymerase IV 0.0156 0.0936 0.4786
Mycobacterium tuberculosis Probable reductase 0.1078 0.711 0.8958
Brugia malayi hypothetical protein 0.0025 0.0059 0.0109
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.012 0.0698 0.1283
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0022 0.0005
Leishmania major basic transcription factor 3a, putative 0.0035 0.0126 0.0356
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0022 0.0005
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0301 0.1908 0.6222
Trypanosoma cruzi DNA polymerase kappa, putative 0.0156 0.0936 0.3021
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0282 0.1779 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0197 0.0199
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0024 0.0012
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.013 0.076 0.1369
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0022 0.0005
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0119 0.0688 0.0745
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0043 0.0183 0.0184
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0007
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0043 0.0183 0.0135
Treponema pallidum oxidoreductase 0.0043 0.0183 0.027
Mycobacterium ulcerans DNA polymerase IV 0.0156 0.0936 0.4786
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0019 0.0005
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1199 0.7915 1
Echinococcus granulosus transcription factor btf3 0.0035 0.0126 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.0534 0.17
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1199 0.7915 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0084 0.0101
Trypanosoma cruzi DNA damage repair protein, putative 0.004 0.0162 0.0474
Echinococcus granulosus thioredoxin glutathione reductase 0.0475 0.3073 0.3398
Schistosoma mansoni lamin 0.0026 0.0069 0.0051
Schistosoma mansoni glutamate synthase 0.0043 0.0183 0.0166
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.1908 0.6222
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0043 0.0183 0.0546
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0043 0.0183 0.0135
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0164 0.0989 0.3196
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0176 0.0521
Onchocerca volvulus 0.0043 0.0183 0.0187
Trichomonas vaginalis glutamate synthase, putative 0.0043 0.0183 0.0261
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.1908 0.6222
Echinococcus multilocularis lamin dm0 0.0026 0.0069 0.0057
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0164 0.0989 1
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0209 0.0302
Brugia malayi jmjC domain containing protein 0.019 0.1163 0.2138
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0126 0.0356
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0577 0.3754 0.6038
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0267 0.0278
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0164 0.0989 0.3196
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0577 0.3754 0.6038
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0119 0.0688 0.2205
Mycobacterium ulcerans glutamate synthase subunit beta 0.0043 0.0183 0.0135
Mycobacterium ulcerans ferredoxin reductase 0.0043 0.0183 0.0135
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0162 0.0474
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0022 0.0005
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0201 0.0605
Brugia malayi PXA domain containing protein 0.0019 0.0022 0.0041
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0099 0.0555 0.102
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0024 0.0007
Echinococcus multilocularis lamin 0.0026 0.0069 0.0057
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0022 0.0005
Onchocerca volvulus 0.0943 0.6203 1
Schistosoma mansoni DNA polymerase eta 0.0181 0.1101 0.1085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0577 0.3754 0.6038
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0267 0.0654
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0267 0.0109
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0019 0.0005
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0846 0.2728
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0059 0.0137
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0043 0.0183 0.0184
Loa Loa (eye worm) hypothetical protein 0.0067 0.0337 0.059
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0019 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0577 0.3754 0.6038
Echinococcus granulosus geminin 0.0334 0.2131 0.235
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0043 0.0183 0.0546
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0084 0.022
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0162 0.0474
Schistosoma mansoni hypothetical protein 0.0019 0.0019 0.0002
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0043 0.0183 0.1002
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0069 0.0126
Brugia malayi 6-phosphofructokinase 0.0106 0.0603 0.1109
Trichomonas vaginalis DNA polymerase eta, putative 0.0156 0.0936 0.1478
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0531 0.1365
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0126 0.0356
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0043 0.0183 0.0432
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0164 0.0989 0.3196
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0043 0.0183 0.0261
Entamoeba histolytica deoxycytidyl transferase, putative 0.013 0.076 0.1976
Loa Loa (eye worm) hypothetical protein 0.0099 0.0557 0.0996

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.