Detailed information for compound 1585670

Basic information

Technical information
  • TDR Targets ID: 1585670
  • Name: N-(5-methyl-1,3,4-thiadiazol-2-yl)pyridine-4- carboxamide
  • MW: 220.251 | Formula: C9H8N4OS
  • H donors: 1 H acceptors: 4 LogP: 0.86 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nnc(s1)NC(=O)c1ccncc1
  • InChi: 1S/C9H8N4OS/c1-6-12-13-9(15-6)11-8(14)7-2-4-10-5-3-7/h2-5H,1H3,(H,11,13,14)
  • InChiKey: CVRBZBXEFHBYPG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(5-methyl-1,3,4-thiadiazol-2-yl)-4-pyridinecarboxamide
  • N-(5-methyl-1,3,4-thiadiazol-2-yl)isonicotinamide
  • STOCK2S-23544
  • Oprea1_818215
  • ZINC00175613
  • Oprea1_783200
  • EU-0000568
  • MLS000534157
  • SMR000141594

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0077 0.1431
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0157 0.0368
Echinococcus granulosus collagen alpha 1VII chain 0.0036 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.002
Onchocerca volvulus 0.0015 0.0005 0.001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0081 0.0188
Trichomonas vaginalis rotamase, putative 0.0034 0.0103 0.0178
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0128 0.0128
Entamoeba histolytica hypothetical protein, conserved 0.0036 0.0114 0.2344
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0191
Toxoplasma gondii kringle domain-containing protein 0.0023 0.0047 0.0344
Mycobacterium ulcerans epimerase 0.002 0.0034 0.0136
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0081 0.0191
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0081 0.0081
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0795 0.4073 1
Schistosoma mansoni lipoxygenase 0.0057 0.0225 0.0522
Plasmodium falciparum thrombospondin-related anonymous protein 0.0036 0.0114 0.2701
Schistosoma mansoni rotamase 0.0035 0.0108 0.0249
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.1235 0.2857
Trichomonas vaginalis rotamase, putative 0.0035 0.0108 0.0186
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Schistosoma mansoni hypothetical protein 0.0036 0.0114 0.0265
Brugia malayi hypothetical protein 0.0017 0.0017 0.004
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.0147 0.0268
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0139 0.1001
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0128 0.03
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0114 0.0268
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0115 0.0267
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0081 0.0191
Onchocerca volvulus 0.002 0.0034 0.0069
Onchocerca volvulus 0.0015 0.0005 0.001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0356 0.0835
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0128 0.0128
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0077 0.1343
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0128 0.0128
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0128 0.03
Schistosoma mansoni hypothetical protein 0.0423 0.2136 0.4942
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0081 0.0619
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.012 0.0553 0.4456
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0215 0.0505
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0077 0.0122
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.002
Loa Loa (eye worm) CUTiclin-Like family member 0.0036 0.0114 0.0268
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0128 0.03
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1469 0.3399
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0128 0.0229
Echinococcus multilocularis pikachurin 0.0023 0.0049 0.0049
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.0147 0.0268
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.0479 0.3796
Onchocerca volvulus 0.0015 0.0005 0.001
Onchocerca volvulus 0.0053 0.0205 0.0422
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0081 0.0189
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0128 0.0128
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0095 0.0621
Brugia malayi hypothetical protein 0.0111 0.0504 0.118
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Loa Loa (eye worm) hypothetical protein 0.0038 0.0127 0.0296
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.0189
Brugia malayi steroid hormone receptor 0.003 0.0081 0.0191
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0036 0.0114 0.0892
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0077 0.0122
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1128 0.1128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0215 0.0499
Echinococcus multilocularis RUN 0.002 0.0034 0.0034
Onchocerca volvulus 0.0047 0.0172 0.0354
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Loa Loa (eye worm) hypothetical protein 0.012 0.0553 0.1295
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.03
Brugia malayi hypothetical protein 0.0016 0.0009 0.002
Schistosoma mansoni DNA helicase recq5 0.0029 0.0081 0.0187
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0036 0.0114 0.2032
Schistosoma mansoni hypothetical protein 0.0205 0.0995 0.2302
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0081 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0081 0.0191
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0036 0.0114 0.0268
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.0479 0.1165
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0069 0.1208
Brugia malayi PXA domain containing protein 0.0039 0.0128 0.03
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0115 0.2361
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0276 0.0647
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0005 0.0011
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0251 0.1235 0.1235
Echinococcus granulosus lamin dm0 0.0082 0.0356 0.0356
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0332 1
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0128 0.0297
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.0479 0.3796
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0069 0.0524
Onchocerca volvulus 0.0036 0.0114 0.0235
Echinococcus granulosus geminin 0.0205 0.0995 0.0995
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0251 0.1235 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0276 0.5043
Echinococcus granulosus FTZ F1 alpha 0.003 0.0081 0.0081
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0139 0.2819
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0114 0.0268
Onchocerca volvulus 0.003 0.0081 0.0167
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.03
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0128 0.0128
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0081 0.0081
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.0081 0.5218
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0108 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0128 0.0229
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0081 0.0188
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0069 0.1183
Onchocerca volvulus 0.003 0.0082 0.0169
Brugia malayi hypothetical protein 0.0039 0.0128 0.03
Brugia malayi nuclear receptor NHR-88 0.003 0.0081 0.0191
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0191
Onchocerca volvulus 0.0015 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0114
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0115 0.8032
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Brugia malayi hypothetical protein 0.0036 0.0114 0.0268
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.013 0.013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0081 0.0081
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0128 0.03
Entamoeba histolytica hypothetical protein 0.0039 0.013 0.2664
Brugia malayi von Willebrand Factor 0.0036 0.0114 0.0268
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Entamoeba histolytica recQ family DNA helicase 0.0015 0.0006 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0081 0.0191
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0078 0.0332 0.6696
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0139 0.3531
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0115 0.0115
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0009 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1235 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0081 0.0188
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0168
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0139 0.5
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0139 0.0139
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0077 0.1549
Brugia malayi Sulfatase family protein 0.0017 0.0017 0.004
Echinococcus granulosus bloom syndrome protein 0.0042 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0139 0.0251
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0266 0.1315 0.1315
Schistosoma mansoni lamin 0.0082 0.0356 0.0825
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0128 0.0128
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0276 0.0276
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0081 0.0167
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0115 0.0115
Brugia malayi nuclear hormone receptor 0.003 0.0081 0.0191
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0081 0.0188
Schistosoma mansoni intermediate filament proteins 0.0082 0.0356 0.0825
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0081 0.0081
Plasmodium vivax thrombospondin-related anonymous protein 0.0036 0.0114 0.2032
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0081 0.0191
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0081 0.0081
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0103 0.0836
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.03
Echinococcus multilocularis slit 2 protein 0.0023 0.0049 0.0049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0215 0.0215
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0128 0.0128
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0005 0.0011
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0129 0.0129
Echinococcus multilocularis lamin dm0 0.0082 0.0356 0.0356
Echinococcus granulosus neurogenic locus notch protein 0.0023 0.0049 0.0049
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0128 0.0297
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0244 0.1945
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0081 0.0081
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0128 0.0128
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.002
Brugia malayi hypothetical protein 0.023 0.1128 0.2644
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0128 0.03
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.0147 0.0345
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0081 0.0191
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0128 0.0297
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0276 0.0639
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0079
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0276 0.5708
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0215 0.0215
Treponema pallidum 76K protein 0.0036 0.0114 0.0267
Brugia malayi Protein kinase domain containing protein 0.0023 0.0047 0.011
Loa Loa (eye worm) leukotriene A4 hydrolase 0.024 0.1181 0.2768
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0114 0.0268
Brugia malayi hypothetical protein 0.002 0.0034 0.0079
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0479 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0081 0.0189
Entamoeba histolytica hypothetical protein, conserved 0.0036 0.0114 0.2344
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0128 0.0297
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0036 0.0114 0.2701
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Onchocerca volvulus 0.0082 0.0356 0.0732
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0006 0.0008
Brugia malayi EGF-like domain containing protein 0.0023 0.0049 0.0114
Echinococcus multilocularis expressed protein 0.0035 0.0108 0.0108
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.0058 0.1008
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0115 0.0115
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0128 0.0128
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0128 0.0297
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0128 0.0297
Schistosoma mansoni lamin 0.0082 0.0356 0.0825
Loa Loa (eye worm) hypothetical protein 0.0389 0.1955 0.4581
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0139 0.2819
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0095 0.1928
Brugia malayi hypothetical protein 0.0027 0.0069 0.0162
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0191
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0128 0.0128
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0479 0.0953
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0215 0.0215
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0081 0.0189
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.03
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0081 0.0081
Onchocerca volvulus 0.0015 0.0005 0.001
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0128 0.03
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0023 0.0049 0.0112
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0162
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0077 0.4859
Brugia malayi Doublecortin family protein 0.002 0.0034 0.0079
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0034 0.0034
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0139 0.0251
Loa Loa (eye worm) TK/ROR protein kinase 0.0023 0.0047 0.011
Brugia malayi Cache domain containing protein 0.0389 0.1955 0.4581
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0077 0.0584
Schistosoma mansoni coup transcription factor 0.003 0.0081 0.0188
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0081 0.0191
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0081 0.0167
Loa Loa (eye worm) hypothetical protein 0.004 0.0134 0.0315
Schistosoma mansoni hypothetical protein 0.0039 0.013 0.03
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0115 0.1123
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0081 0.0081
Brugia malayi ecdysteroid receptor 0.003 0.0081 0.0191
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0081 0.1578
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0128 0.0229
Loa Loa (eye worm) hypothetical protein 0.0023 0.0047 0.011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0139 0.0326
Echinococcus multilocularis lamin 0.0082 0.0356 0.0356
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0034 0.0136
Loa Loa (eye worm) CUTiclin family member 0.0036 0.0114 0.0268
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0139 0.2482
Schistosoma mansoni polycystin 1-related 0.002 0.0034 0.0078
Mycobacterium ulcerans hypothetical protein 0.002 0.0034 0.0136
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0017 0.0017 0.0036
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.0479 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.03
Schistosoma mansoni nuclear hormone receptor 0.003 0.0081 0.0188
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.4305 0.4305
Echinococcus granulosus expressed protein 0.0035 0.0108 0.0108
Brugia malayi hypothetical protein 0.0018 0.0019 0.0044
Schistosoma mansoni hypothetical protein 0.0036 0.0114 0.0265
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0128 0.0297
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0128 0.0297
Brugia malayi phosphofructokinase 0.0106 0.0479 0.1123
Echinococcus multilocularis neurogenic locus notch protein 0.0023 0.0049 0.0049
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0115 0.0115
Schistosoma mansoni cell polarity protein 0.0023 0.0049 0.0112
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0006 0.0013
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0139 0.0328
Echinococcus granulosus histone lysine methyltransferase setb 0.012 0.0553 0.0553
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0081 0.0191
Echinococcus granulosus RUN 0.002 0.0034 0.0034
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0082 0.0356 0.0835
Schistosoma mansoni hypothetical protein 0.0023 0.0047 0.0109
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0036 0.0114 0.0268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0215 0.0499
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0191
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0128 0.0297
Echinococcus multilocularis geminin 0.0205 0.0995 0.0995
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0553 0.1279
Mycobacterium ulcerans endonuclease IV 0.0078 0.0332 0.2587
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.012 0.0553 0.0553
Onchocerca volvulus 0.0036 0.0114 0.0235
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0251 0.1235 0.1235
Trichomonas vaginalis set domain proteins, putative 0.0947 0.4867 1
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0128 0.0128
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0128 0.03
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0036 0.0114 0.02
Onchocerca volvulus 0.0036 0.0114 0.0235
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1128 0.1128
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0115 0.0202
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.1235 0.2857
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0191
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0479 0.1123
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0103 0.2064
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0128 0.0128
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0036 0.0114 0.2032
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0077 0.0122
Echinococcus multilocularis tissue type plasminogen activator 0.0023 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.004
Leishmania major hypothetical protein, conserved 0.0027 0.0069 0.0187
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.002
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0356 0.0835
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0191
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0034 0.0079
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0077 0.0122
Brugia malayi Zona pellucida-like domain containing protein 0.0036 0.0114 0.0268
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0081 0.0081
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0077 0.0584
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0081 0.0081
Entamoeba histolytica hypothetical protein 0.0039 0.013 0.2664
Brugia malayi intermediate filament protein 0.0082 0.0356 0.0835
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0081 0.0081
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0081 0.0188
Echinococcus multilocularis expressed protein 0.075 0.3839 0.3839
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0114 0.0268
Schistosoma mansoni cpg binding protein 0.003 0.0082 0.0191
Brugia malayi Pre-SET motif family protein 0.012 0.0553 0.1295
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Brugia malayi laminin alpha chain 0.0023 0.0049 0.0114
Schistosoma mansoni slit 0.0023 0.0049 0.0112
Schistosoma mansoni survival motor neuron protein 0.0047 0.0172 0.0399
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0553 0.1279
Loa Loa (eye worm) hypothetical protein 0.0078 0.0332 0.0778
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0115 0.027
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0095 0.0401
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0081 0.0167
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0081 0.0191
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1235 1
Onchocerca volvulus 0.0023 0.0047 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0081 0.0191
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0842 0.4321 1
Onchocerca volvulus 0.0015 0.0005 0.001
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0878 0.4509 0.4509
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0128 0.0128
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0077 0.0174
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0069 0.134
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0279 0.0646
Brugia malayi hypothetical protein 0.002 0.0034 0.0079
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0081 0.0188
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0114 0.0268
Onchocerca volvulus 0.0015 0.0005 0.001
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0103 0.0476
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0108 0.0252
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0077 0.1343
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0115 0.0527 0.0527
Echinococcus granulosus tumor protein p63 0.0364 0.1828 0.1828
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0078 0.0332 0.2587
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.027
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0139 0.0326
Echinococcus multilocularis thyroid hormone receptor alpha 0.0296 0.1469 0.1469
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0081 0.0191
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0103 0.0803
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0553 0.1279
Echinococcus granulosus intermediate filament protein 0.0082 0.0356 0.0356
Entamoeba histolytica elongation factor-2 kinase, putative 0.0036 0.0114 0.2344
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0172 0.0404
Schistosoma mansoni hypothetical protein 0.002 0.0034 0.0078
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0081 0.0081
Echinococcus granulosus slit 2 protein 0.0023 0.0049 0.0049
Brugia malayi 6-phosphofructokinase 0.0106 0.0479 0.1123
Schistosoma mansoni hypothetical protein 0.0266 0.1315 0.3043
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0115 0.0202
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0047 0.0872
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0128 0.0128
Schistosoma mansoni lipoxygenase 0.002 0.0034 0.0078
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0425 0.2142 0.4958
Schistosoma mansoni DNA helicase recq1 0.0029 0.0081 0.0187
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0191
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0479 0.0953
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0128 0.0128
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0081 0.0081
Schistosoma mansoni ap endonuclease 0.0041 0.0139 0.0322
Echinococcus granulosus pikachurin 0.0023 0.0049 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0128 0.0229
Brugia malayi Zona pellucida-like domain containing protein 0.0036 0.0114 0.0268
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0205 0.0475
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0081 0.0619
Brugia malayi hypothetical protein 0.0016 0.0009 0.002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0081 0.0188
Entamoeba histolytica hypothetical protein 0.0039 0.013 0.2664
Onchocerca volvulus 0.0015 0.0005 0.001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0251 0.1235 1
Schistosoma mansoni hypothetical protein 0.0205 0.0995 0.2302
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0047 0.0172 0.0399
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0479 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0139 0.0776
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0081 0.0191
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.028 0.0656
Brugia malayi hypothetical protein 0.0039 0.0128 0.03
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Brugia malayi Cytochrome P450 family protein 0.0068 0.028 0.0656
Schistosoma mansoni cpg binding protein 0.0031 0.0091 0.0211
Entamoeba histolytica hypothetical protein 0.0039 0.0128 0.2634
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0036 0.0114 0.2032
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0479 0.111
Echinococcus multilocularis leukotriene A 4 hydrolase 0.024 0.1181 0.1181
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.0479 0.0479
Echinococcus multilocularis tumor protein p63 0.0364 0.1828 0.1828
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.0479 0.3641
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0108 0.0252
Loa Loa (eye worm) phosphofructokinase 0.0106 0.0479 0.1123
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0036 0.0114 0.2701
Echinococcus granulosus expressed protein 0.075 0.3839 0.3839
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0036 0.0114 0.0268
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0005 0.0011
Onchocerca volvulus 0.0082 0.0356 0.0732
Loa Loa (eye worm) hypothetical protein 0.0038 0.0127 0.0296
Schistosoma mansoni ap endonuclease 0.0041 0.0139 0.0322
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0479 0.0953
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0115 0.0575
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0078 0.0332 0.5991
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0276 0.0276
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0115 0.2313
Schistosoma mansoni loxhd1 0.002 0.0034 0.0078
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0128 0.0297
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0128 0.03
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0009 0.002
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0134 0.0134
Loa Loa (eye worm) RecQ helicase 0.0042 0.0147 0.0345
Treponema pallidum hypothetical protein 0.0036 0.0114 0.0267
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0133 0.3337
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0215 0.0505
Loa Loa (eye worm) hypothetical protein 0.0637 0.3252 0.7618
Loa Loa (eye worm) abnormal epIthelia family member 0.0023 0.0049 0.0114
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0034 0.0566
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0034 0.0034
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0077 0.0122
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0034 0.0034
Brugia malayi 6-phosphofructokinase 0.0106 0.0479 0.1123
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0081 0.0191
Echinococcus granulosus voltage dependent calcium channel subunit 0.0878 0.4509 0.4509
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.013 0.03
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0081 0.0191
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0081 0.0081
Brugia malayi CXXC zinc finger family protein 0.003 0.0082 0.0193
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0128 0.0297
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0034 0.0034
Brugia malayi laminin-like protein K08C7.3 precursor 0.0023 0.0049 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0081 0.0191
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0139 0.0139
Echinococcus granulosus cpg binding protein 0.0031 0.0091 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0081 0.0191
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0114 0.2032
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0023 0.0049 0.0114
Echinococcus multilocularis bloom syndrome protein 0.0042 0.0147 0.0147
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.012 0.0553 0.1279
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0215 0.0499
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.012 0.0553 0.0553
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0077 0.1431
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0139 0.2863
Schistosoma mansoni rab6-interacting 0.002 0.0034 0.0078
Onchocerca volvulus 0.0015 0.0005 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0081 0.0191
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0481
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0081 0.0081
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0128 0.0297
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0115 0.2313
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0036 0.0114 0.0114
Chlamydia trachomatis endonuclease IV 0.0078 0.0332 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0128 0.0229
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0011
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0055 0.041
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1469 0.3399
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0095 0.0159
Loa Loa (eye worm) hypothetical protein 0.023 0.1128 0.2644
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0009 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0081 0.0081
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0009 0.0009
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1931 1 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.0069 0.0159
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0479 1
Entamoeba histolytica hypothetical protein 0.0039 0.0128 0.2634
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0081 0.0191
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0266 0.1315 0.1315
Toxoplasma gondii microneme protein MIC2 0.0036 0.0114 0.0892
Echinococcus granulosus tissue type plasminogen activator 0.0023 0.0047 0.0047
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0832 0.4268 1
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0128 0.0128
Onchocerca volvulus 0.0036 0.0114 0.0235
Loa Loa (eye worm) doublecortin family protein 0.002 0.0034 0.0079
Onchocerca volvulus 0.0036 0.0114 0.0235
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0128 0.03
Plasmodium falciparum cysteine repeat modular protein 1 0.0023 0.0047 0.044
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0128 0.0229
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0077 0.0122
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0276 0.5708
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0009 0.002
Entamoeba histolytica hypothetical protein 0.0039 0.0128 0.2634
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0157 0.0368
Onchocerca volvulus 0.012 0.0553 0.1136
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0128 0.0229
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0128 0.0128
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.024 0.1181 0.2733
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0479 0.111
Toxoplasma gondii endonuclease IV APN 0.0078 0.0332 0.2663
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0079
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0139 0.1707
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0139 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.03
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0095 0.1877
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0077 0.0584
Echinococcus multilocularis musashi 0.0082 0.0356 0.0356
Toxoplasma gondii aldehyde dehydrogenase 0.0251 0.1235 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0225 0.0225
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0081 0.0188
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0114 0.0268
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0276 0.0647
Brugia malayi nuclear receptor RXR 0.0016 0.0009 0.002
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0129 0.0129
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0128 0.03
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Brugia malayi hypothetical protein 0.0245 0.1203 0.2818
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0023 0.0047 0.0805
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0479 0.0953
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0013
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0139 0.1001
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0081 0.0081
Echinococcus granulosus lamin 0.0082 0.0356 0.0356
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.2136 0.2136
Brugia malayi Pre-SET motif family protein 0.0832 0.4268 1
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.0479 0.0479
Entamoeba histolytica hypothetical protein 0.0039 0.013 0.2664
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0103 0.2064
Toxoplasma gondii exonuclease III APE 0.0041 0.0139 0.1093
Schistosoma mansoni hypothetical protein 0.0454 0.2293 0.5307
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0128 0.0297
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0191
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0114 0.0268
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0081 0.0191
Brugia malayi follicle stimulating hormone receptor 0.023 0.1129 0.2645
Schistosoma mansoni cpg binding protein 0.0031 0.0091 0.0211
Onchocerca volvulus 0.0947 0.4867 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0479 0.1123
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0069 0.1183
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0081 0.0081
Onchocerca volvulus 0.0036 0.0114 0.0235
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0128 0.03
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0114 0.0268
Echinococcus multilocularis cpg binding protein 0.0031 0.0091 0.0091
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0115 0.0267
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0115 0.0115
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0009 0.002
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0356 0.0835
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0276 0.5734
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.1129 0.2645
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0128 0.0297
Schistosoma mansoni serine-rich repeat protein 0.0454 0.2293 0.5307
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0034 0.0034
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0077 0.0122
Onchocerca volvulus 0.0036 0.0114 0.0235
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0069 0.134
Loa Loa (eye worm) hypothetical protein 0.0081 0.0348 0.0817
Echinococcus granulosus dnaJ subfamily B 0.0423 0.2136 0.2136
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0115 0.0115
Entamoeba histolytica hypothetical protein 0.0036 0.0114 0.2344
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0081 0.0191
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0103 0.2114
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0114 0.0268
Onchocerca volvulus 0.0015 0.0005 0.001
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0082 0.0193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0081 0.0191
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.013 0.013
Onchocerca volvulus 0.002 0.0034 0.0069
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0115 0.0202
Brugia malayi PXA domain containing protein 0.0039 0.0128 0.03
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0011
Schistosoma mansoni rab6-interacting 0.002 0.0034 0.0078
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.004
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0034 0.0069
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0016 0.0011 0.0025
Plasmodium vivax SET domain protein, putative 0.012 0.0553 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0081 0.0191
Onchocerca volvulus 0.0015 0.0005 0.001
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0005 0.0011
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0034 0.0136
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0081 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0081 0.0191
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1235 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0081 0.0188
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0114 0.0268
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0009 0.002
Echinococcus granulosus leukotriene A 4 hydrolase 0.024 0.1181 0.1181
Brugia malayi hypothetical protein 0.0039 0.013 0.0304
Schistosoma mansoni laminin gamma-3 chain 0.0023 0.0049 0.0112
Brugia malayi Kringle domain containing protein 0.0023 0.0047 0.011
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0276 0.1929
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0479 1
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0078 0.0332 0.0778
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0479 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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