Detailed information for compound 1591710

Basic information

Technical information
  • TDR Targets ID: 1591710
  • Name: NCI60_011312
  • MW: 270.239 | Formula: C11H14N2O6
  • H donors: 4 H acceptors: 5 LogP: -2.66 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC[C@H]1C2OC(n3c1cc(=O)[nH]c3=O)C(C2O)O
  • InChi: 1S/C11H14N2O6/c14-2-1-4-5-3-6(15)12-11(18)13(5)10-8(17)7(16)9(4)19-10/h3-4,7-10,14,16-17H,1-2H2,(H,12,15,18)/t4-,7?,8?,9?,10?/m1/s1
  • InChiKey: PWMCYEQTMFUEHJ-FRDRMYAUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5',6-Cyclouridine, 5'-deoxy-5'-(2-hydroxyethyl)-,(R)
  • NSC634016

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.0479
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0018 0.0017
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0395 0.1269
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0127 0.0247
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0082 0.0544 0.0544
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0374 0.1787
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0196 0.0479
Brugia malayi follicle stimulating hormone receptor 0.0226 0.1692 0.4129
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0082 0.0544 0.1327
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0374 0.1072
Brugia malayi conserved hypotetical protein 0.0039 0.0196 0.0479
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.3115 0.893
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.027 0.6833
Schistosoma mansoni lamin 0.0027 0.0099 0.0099
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0082 0.0544 0.1559
Echinococcus granulosus dnaJ subfamily B 0.0404 0.3115 1
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0386 0.0942
Giardia lamblia Synaptic glycoprotein SC2 0.0048 0.027 0.5
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0138 0.3493
Onchocerca volvulus 0.0028 0.0113 0.0083
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0045 0.011
Trypanosoma cruzi ISWI complex protein 0.0015 0.0004 0.0098
Brugia malayi Steroid receptor seven-up type 2 0.0082 0.0544 0.1327
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0196 0.063
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0039 0.0196 0.0479
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0368 0.283 0.9085
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.027 0.6833
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0022 0.0054
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0234 0.057
Schistosoma mansoni zinc finger protein 0.0039 0.0196 0.0196
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.027 0.6833
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0376 0.0375
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0196 0.063
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0039 0.0196 0.0196
Schistosoma mansoni RAR-like nuclear receptor 0.0082 0.0544 0.0544
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0113 0.0275
Brugia malayi nuclear hormone receptor family member odr-7 0.0039 0.0196 0.0479
Mycobacterium ulcerans hydrolase/amidase 0.0276 0.2093 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.057
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0196 0.0479
Echinococcus granulosus FTZ F1 alpha 0.0082 0.0544 0.1746
Schistosoma mansoni nuclear hormone receptor 0.0082 0.0544 0.0544
Schistosoma mansoni nuclear receptor nhr-48 0.0039 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0082 0.0544 0.1327
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0048 0.027 0.6833
Entamoeba histolytica hypothetical protein 0.0105 0.0727 1
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0374 0.0732
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0039 0.0196 0.0563
Schistosoma mansoni hypothetical protein 0.002 0.0045 0.0045
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0082 0.0544 0.1559
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0082 0.0544 0.1327
Echinococcus granulosus zinc finger protein 0.0021 0.005 0.016
Brugia malayi Cytochrome P450 family protein 0.0032 0.0138 0.0337
Schistosoma mansoni thyroid hormone receptor 0.0451 0.3488 0.3488
Brugia malayi PHD-finger family protein 0.0026 0.0091 0.0222
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0082 0.0544 0.1559
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0082 0.0544 0.1746
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0048 0.027 0.0529
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0196 0.0587
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0082 0.0544 0.1327
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.027 1
Schistosoma mansoni hypothetical protein 0.0368 0.283 0.283
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0082 0.0544 0.1327
Brugia malayi nuclear hormone receptor 0.0039 0.0196 0.0479
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0082 0.0544 0.1327
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.1692 0.4129
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0138 0.066
Brugia malayi nuclear receptor NHR-67 0.0039 0.0196 0.0479
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0196 0.0587
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0082 0.0544 0.1327
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0073 0.0073
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0082 0.0544 0.1327
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0048 0.027 0.027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0127 0.0126
Echinococcus granulosus thyroid hormone receptor alpha 0.0039 0.0196 0.063
Brugia malayi steroid hormone receptor 0.0082 0.0544 0.1327
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0386 0.0386
Brugia malayi Cytochrome P450 family protein 0.0033 0.0154 0.0375
Schistosoma mansoni cpg binding protein 0.0032 0.014 0.014
Schistosoma mansoni coup transcription factor 0.0082 0.0544 0.0544
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0039 0.0196 0.0479
Loa Loa (eye worm) hypothetical protein 0.0068 0.0432 0.1054
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0138 0.0337
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.0479
Loa Loa (eye worm) hypothetical protein 0.0048 0.027 0.0659
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0048 0.027 0.0774
Schistosoma mansoni hypothetical protein 0.0329 0.2511 0.2511
Echinococcus granulosus tar DNA binding protein 0.0063 0.0386 0.1239
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0082 0.0544 0.0544
Echinococcus multilocularis nuclear receptor nhr 48 0.0039 0.0196 0.0563
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0636 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0636 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0138 0.0337
Schistosoma mansoni hypothetical protein 0.0404 0.3115 0.3115
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0181 0.0518
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0082 0.0544 0.1327
Brugia malayi Nuclear hormone receptor-like 1 0.0082 0.0544 0.1327
Brugia malayi glutathione reductase 0.0037 0.0182 0.0444
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0082 0.0544 0.2679
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0196 0.0563
Loa Loa (eye worm) steroid hormone receptor 0.0082 0.0544 0.1327
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.027 0.6833
Brugia malayi hypothetical protein 0.0039 0.0196 0.0479
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0082 0.0544 0.1559
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0039 0.0196 0.0196
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0048 0.027 0.0529
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0048 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.0479
Echinococcus granulosus ecdysone induced protein 78C 0.0082 0.0544 0.1746
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0082 0.0544 0.1559
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.0653 0.5107 1
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0138 0.0337
Brugia malayi hypothetical protein 0.0527 0.4099 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0018 0.005
Leishmania major hypothetical protein, conserved 0.0015 0.0004 0.0098
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0374 0.1787
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.0479
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0374 0.0374
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0386 0.1106
Echinococcus multilocularis cpg binding protein 0.0032 0.014 0.0402
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0154 0.0375
Schistosoma mansoni nuclear receptor 0.0039 0.0196 0.0196
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0374 0.9461
Brugia malayi Synaptic glycoprotein SC2 0.0048 0.027 0.0659
Brugia malayi TAR-binding protein 0.0063 0.0386 0.0942
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0374 0.1787
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0374 0.1201
Brugia malayi hypothetical protein 0.0044 0.0234 0.057
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1761 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0082 0.0544 0.2679
Loa Loa (eye worm) hypothetical protein 0.0082 0.0544 0.1327
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.0479
Entamoeba histolytica hypothetical protein 0.0105 0.0727 1
Echinococcus multilocularis lamin dm0 0.0027 0.0099 0.0283
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.0479
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0004
Loa Loa (eye worm) DR-78 0.0039 0.0196 0.0479
Plasmodium vivax glutathione reductase, putative 0.0037 0.0182 0.3849
Echinococcus granulosus lamin dm0 0.0027 0.0099 0.0317
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0182 0.0444
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0105 0.0727 0.2085
Loa Loa (eye worm) hypothetical protein 0.0047 0.0258 0.063
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0082 0.0544 0.0544
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0196 0.0563
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0127 0.0126
Onchocerca volvulus Bile acid receptor homolog 0.0082 0.0544 0.2679
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0039 0.0196 0.063
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0082 0.0544 0.1746
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0196 0.063
Brugia malayi Cytochrome P450 family protein 0.0032 0.0138 0.0337
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0395 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.0479
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0082 0.0544 0.1746
Loa Loa (eye worm) glutathione reductase 0.0037 0.0182 0.0444
Loa Loa (eye worm) nuclear hormone receptor 0.0039 0.0196 0.0479
Schistosoma mansoni retinoic acid receptor RXR 0.0082 0.0544 0.0544
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0082 0.0544 0.1327
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0561 0.8816
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0082 0.0544 0.1327
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0082 0.0544 0.1559
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0561 0.8816
Loa Loa (eye worm) hypothetical protein 0.0082 0.0544 0.1327
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0561 0.8816
Trypanosoma brucei trypanothione reductase 0.0037 0.0182 0.4596
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0082 0.0544 0.1327
Loa Loa (eye worm) hypothetical protein 0.0043 0.0228 0.0556
Loa Loa (eye worm) hypothetical protein 0.0039 0.02 0.0489
Brugia malayi orphan nuclear receptor NR2E1 0.0039 0.0196 0.0479
Brugia malayi Thioredoxin reductase 0.0037 0.0182 0.0444
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0082 0.0544 0.1327
Schistosoma mansoni zinc finger protein 0.0015 0.0004 0.0004
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0048 0.027 0.0659
Loa Loa (eye worm) hypothetical protein 0.0048 0.027 0.0659
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0082 0.0544 0.1327
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0105 0.0727 0.2334
Echinococcus multilocularis geminin 0.0329 0.2511 0.7199
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0082 0.0544 0.1746
Loa Loa (eye worm) hypothetical protein 0.0082 0.0544 0.1327
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0234 0.0233
Leishmania major trypanothione reductase 0.0037 0.0182 0.4596
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0561 0.8816
Brugia malayi Bromodomain containing protein 0.0074 0.0478 0.1166
Brugia malayi nuclear receptor RXR 0.0039 0.0196 0.0479
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0258 0.0258
Schistosoma mansoni cpg binding protein 0.0032 0.014 0.014
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0386 0.0386
Schistosoma mansoni bromodomain containing protein 0.0063 0.0387 0.0387
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0099 0.0241
Loa Loa (eye worm) nuclear receptor NHR-67 0.0039 0.0196 0.0479
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0636 1
Schistosoma mansoni thyroid hormone receptor 0.0451 0.3488 0.3488
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0018 0.0056
Echinococcus multilocularis synaptic glycoprotein sc2 0.0048 0.027 0.0774
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0059
Trypanosoma cruzi ISWI complex protein 0.0015 0.0004 0.0098
Brugia malayi ecdysteroid receptor 0.0082 0.0544 0.1327
Brugia malayi nuclear receptor RXR 0.0044 0.0234 0.057
Loa Loa (eye worm) hypothetical protein 0.0082 0.0544 0.1327
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0082 0.0544 0.0544
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0082 0.0544 0.1327
Schistosoma mansoni cpg binding protein 0.0028 0.0113 0.0112
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0073 0.0233
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0386 0.0386
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0561 0.8816
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0196 0.0196
Echinococcus granulosus cpg binding protein 0.0032 0.014 0.045
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0082 0.0544 0.1327
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0113 0.0362
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0163 0.0524
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0163 0.0468
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.057
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0186 0.0596
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0182 0.0444
Echinococcus multilocularis musashi 0.0027 0.0099 0.0283
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.0479
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.0479
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0342 0.067
Plasmodium vivax polyprenol reductase, putative 0.0048 0.027 1
Leishmania major cytochrome p450-like protein 0.0032 0.0138 0.3493
Loa Loa (eye worm) hypothetical protein 0.0026 0.0095 0.0232
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0395 0.1133
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0048 0.027 0.0867
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0258 0.0258
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0181 0.058
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0234 0.057
Brugia malayi hypothetical protein 0.0044 0.0234 0.057
Plasmodium falciparum polyprenol reductase, putative 0.0048 0.027 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0099 0.0241
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0386 0.0942
Echinococcus granulosus geminin 0.0329 0.2511 0.8061
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0082 0.0544 0.0544
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0395 0.0965
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0386 0.0942
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.0479
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0368 0.283 0.8113
Brugia malayi nuclear receptor NHR-88 0.0082 0.0544 0.1327
Brugia malayi Bromodomain containing protein 0.0037 0.0182 0.0443
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0386 0.0386
Schistosoma mansoni transcription factor LCR-F1 0.0105 0.0727 0.0727
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0196 0.0196
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0561 0.8816
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0082 0.0544 0.1327
Schistosoma mansoni steroid hormone receptor ad4bp 0.0082 0.0544 0.0544
Brugia malayi Pre-SET motif family protein 0.0206 0.1534 0.3742
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0073 0.0208
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0127 0.0362
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0186 0.0532
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.036 0.1031
Brugia malayi nuclear hormone receptor family member nhr-6 0.0039 0.0196 0.0479
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0374 0.0374
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.036 0.1154
Echinococcus multilocularis ecdysone induced protein 78C 0.0082 0.0544 0.1559
Trypanosoma brucei ISWI complex protein 0.0015 0.0004 0.0098
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0082 0.0544 0.1746
Brugia malayi tailless protein 0.0039 0.0196 0.0479
Schistosoma mansoni hypothetical protein 0.0329 0.2511 0.2511
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.0479
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0395 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.0479
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0374 0.5879
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0044 0.0234 0.0749
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0138 0.3493
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1534 0.3742
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0196 0.0563
Onchocerca volvulus 0.0039 0.0196 0.0587
Loa Loa (eye worm) hypothetical protein 0.0527 0.4099 1
Brugia malayi RNA binding protein 0.0063 0.0386 0.0942
Echinococcus granulosus intermediate filament protein 0.0027 0.0099 0.0317
Echinococcus multilocularis thyroid hormone receptor alpha 0.0451 0.3488 1
Entamoeba histolytica hypothetical protein 0.0105 0.0727 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0082 0.0544 0.1327
Onchocerca volvulus 0.0082 0.0544 0.2679
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0182 0.4596
Mycobacterium tuberculosis Probable reductase 0.0084 0.0561 0.8816
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0258 0.0828
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0395 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0113 0.0275
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.023 0.1725 0.1725
Loa Loa (eye worm) hypothetical protein 0.0082 0.0544 0.1327
Brugia malayi intermediate filament protein 0.0027 0.0099 0.0241
Schistosoma mansoni zinc finger protein 0.0021 0.005 0.005
Toxoplasma gondii thioredoxin reductase 0.0037 0.0182 0.0356
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0082 0.0544 0.1746
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0082 0.0544 0.1327
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0082 0.0544 0.0544
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0044 0.0234 0.0669
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0258 0.074
Brugia malayi nuclear hormone receptor 0.0082 0.0544 0.1327
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0048 0.027 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0099 0.0099
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0395 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0099 0.0241
Loa Loa (eye worm) hypothetical protein 0.0082 0.0544 0.1327
Onchocerca volvulus 0.003 0.0127 0.0167
Echinococcus granulosus nuclear receptor nhr 48 0.0039 0.0196 0.063
Brugia malayi photoreceptor-specific nuclear receptor 0.0082 0.0544 0.1327
Mycobacterium ulcerans hypothetical protein 0.0048 0.027 0.1291
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0048 0.027 0.0529
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0636 1
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0182 0.3849
Loa Loa (eye worm) hypothetical protein 0.0048 0.027 0.0659
Echinococcus granulosus lamin 0.0027 0.0099 0.0317
Onchocerca volvulus 0.0039 0.0196 0.0587
Echinococcus multilocularis lamin 0.0027 0.0099 0.0283
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0395 0.0965
Entamoeba histolytica hypothetical protein 0.0105 0.0727 1
Schistosoma mansoni hypothetical protein 0.0105 0.0727 0.0727
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0018 0.0017
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0039 0.0196 0.0563
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0138 0.3493
Schistosoma mansoni nuclear receptor 0.0039 0.0196 0.0196
Brugia malayi nuclear receptor NHR-88 0.0039 0.0196 0.0479
Loa Loa (eye worm) RNA binding protein 0.0063 0.0386 0.0942
Onchocerca volvulus 0.0048 0.027 0.1032
Echinococcus multilocularis FTZ F1 alpha 0.0082 0.0544 0.1559
Schistosoma mansoni lamin 0.0027 0.0099 0.0099
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0099 0.0241
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0395 0.274
Brugia malayi ecdysone receptor 0.0039 0.0196 0.0479
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0082 0.0544 0.1327
Onchocerca volvulus 0.0235 0.1761 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.057
Loa Loa (eye worm) hypothetical protein 0.0039 0.0196 0.0479
Echinococcus granulosus synaptic glycoprotein sc2 0.0048 0.027 0.0867
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0044 0.0234 0.057
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0044 0.0234 0.0233
Echinococcus multilocularis zinc finger protein 0.0021 0.005 0.0143
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0182 0.2856
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0082 0.0544 0.1327
Brugia malayi hypothetical protein 0.0105 0.0727 0.1774
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0082 0.0544 0.1746
Brugia malayi hypothetical protein 0.0039 0.0196 0.0479
Brugia malayi Pre-SET motif family protein 0.003 0.0127 0.0309
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0048 0.027 0.6833
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0082 0.0544 0.1327

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.