Detailed information for compound 159215

Basic information

Technical information
  • TDR Targets ID: 159215
  • Name: N-benzyl-9-chloro-2-(furan-2-yl)-[1,2,4]triaz olo[1,5-c]quinazolin-5-amine
  • MW: 375.811 | Formula: C20H14ClN5O
  • H donors: 1 H acceptors: 3 LogP: 4.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)c1nc(nn1c(n2)NCc1ccccc1)c1ccco1
  • InChi: 1S/C20H14ClN5O/c21-14-8-9-16-15(11-14)19-24-18(17-7-4-10-27-17)25-26(19)20(23-16)22-12-13-5-2-1-3-6-13/h1-11H,12H2,(H,22,23)
  • InChiKey: LREUJMKERSIZBI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-benzyl-9-chloro-2-(2-furyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
  • 9-chloro-2-(furan-2-yl)-N-(phenylmethyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
  • benzyl-[9-chloro-2-(2-furyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]amine
  • 9-chloro-2-furan-2-yl-N-(phenylmethyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
  • 9-chloro-2-(2-furyl)-N-(phenylmethyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adenosine A1 receptor Starlite/ChEMBL References
Homo sapiens adenosine A3 receptor Starlite/ChEMBL References
Rattus norvegicus Adenosine A2a receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Adenosine A1 receptor   326 aa 304 aa 21.1 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 306 aa 21.2 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 323 aa 20.7 %
Loa Loa (eye worm) neuropeptide F receptor Adenosine A1 receptor   326 aa 316 aa 19.9 %
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A1 receptor   326 aa 327 aa 24.8 %
Schistosoma mansoni dro/myosuppressin receptor Adenosine A1 receptor   326 aa 326 aa 22.1 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A1 receptor   326 aa 286 aa 26.9 %
Echinococcus multilocularis allatostatin A receptor Adenosine A2a receptor   410 aa 372 aa 22.8 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A2a receptor   410 aa 352 aa 23.6 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Adenosine A2a receptor   410 aa 346 aa 28.3 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 300 aa 24.3 %
Onchocerca volvulus Adenosine A2a receptor   410 aa 356 aa 23.9 %
Onchocerca volvulus Adenosine A2a receptor   410 aa 337 aa 23.1 %
Echinococcus granulosus allatostatin A receptor Adenosine A2a receptor   410 aa 368 aa 22.6 %
Echinococcus multilocularis neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Adenosine A1 receptor   326 aa 295 aa 28.1 %
Schistosoma mansoni biogenic amine (5HT) receptor Adenosine A2a receptor   410 aa 399 aa 28.1 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Adenosine A2a receptor   410 aa 342 aa 23.1 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 311 aa 21.2 %
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 305 aa 21.0 %
Echinococcus granulosus neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Adenosine A2a receptor   410 aa 340 aa 27.9 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 274 aa 22.6 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Adenosine A2a receptor   410 aa 366 aa 25.4 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A1 receptor   326 aa 317 aa 24.6 %
Echinococcus granulosus thyrotropin releasing hormone receptor Adenosine A2a receptor   410 aa 342 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Echinococcus multilocularis neuropeptide s receptor 0.0225 0.073 0.0724
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Schistosoma mansoni tubulin subunit beta 0.0045 0.0084 0.0124
Plasmodium falciparum subtilisin-like protease 2 0.0055 0.0123 0.2451
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.0071 0.0065
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Trichomonas vaginalis conserved hypothetical protein 0.025 0.0823 0.295
Loa Loa (eye worm) TYRA-2 protein 0.0225 0.073 0.171
Onchocerca volvulus 0.0225 0.073 0.2645
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Schistosoma mansoni tubulin subunit beta 0.0045 0.0084 0.0124
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.025 0.0823 0.295
Schistosoma mansoni neuropeptide F-like receptor 0.0225 0.073 0.1145
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0225 0.073 0.0724
Trichomonas vaginalis conserved hypothetical protein 0.025 0.0823 0.295
Brugia malayi SRC-1 0.0041 0.0071 0.0166
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0055 0.0123 0.5
Echinococcus granulosus membrane bound transcription factor site 1 0.0055 0.0123 0.0117
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0525 0.176
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0306 0.1021 0.3744
Toxoplasma gondii subtilisin SUB11 0.0055 0.0123 0.2451
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.0839 0.1969
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0306 0.1021 0.3744
Loa Loa (eye worm) hypothetical protein 0.1203 0.4238 1
Schistosoma mansoni serine-type protease inhibitor 0.1784 0.6326 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0166 0.0519 0.0513
Brugia malayi hypothetical protein 0.0225 0.073 0.1721
Schistosoma mansoni neuropeptide receptor 0.0225 0.073 0.1145
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0364 0.1229 1
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Echinococcus granulosus ephrin type A receptor 4 A 0.0208 0.0669 0.0664
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0071 0.0065
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Echinococcus granulosus somatostatin receptor 0.0225 0.073 0.0724
Brugia malayi Transforming growth factor beta like domain containing protein 0.0032 0.004 0.0094
Echinococcus granulosus peptide allatostatin:somatostatin 0.0225 0.073 0.0724
Entamoeba histolytica tubulin family protein 0.0045 0.0084 1
Trichomonas vaginalis hypothetical protein 0.025 0.0823 0.295
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0742 0.2586 0.2582
Echinococcus multilocularis ephrin type A receptor 4 A 0.0208 0.0669 0.0664
Giardia lamblia Furin precursor putative serine protease 0.025 0.0823 0.5254
Loa Loa (eye worm) apoptosis regulator protein 0.0166 0.0519 0.1212
Onchocerca volvulus 0.0225 0.073 0.2645
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0038 0.0062 0.0145
Loa Loa (eye worm) hypothetical protein 0.0461 0.1576 0.371
Brugia malayi RE15519p 0.0225 0.073 0.1721
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0126 0.0377 0.0371
Echinococcus granulosus rhodopsin orphan GPCR 0.0225 0.073 0.0724
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Schistosoma mansoni furin-1 (S08 family) 0.0516 0.1775 0.2799
Trichomonas vaginalis conserved hypothetical protein 0.025 0.0823 0.295
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0038 0.0062 0.0056
Onchocerca volvulus Neuropeptide F receptor homolog 0.0225 0.073 0.2645
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0123 0.0153
Schistosoma mansoni adenoreceptor 0.0225 0.073 0.1145
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0108 0.0311 0.0305
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Onchocerca volvulus 0.0038 0.0062 0.0223
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0225 0.073 0.0724
Schistosoma mansoni tyrosine kinase 0.0145 0.0445 0.0694
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0045 0.0084 0.0079
Brugia malayi Furin-like cysteine rich region family protein 0.0145 0.0445 0.105
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0306 0.1021 0.3744
Loa Loa (eye worm) endoprotease bli-4 0.1203 0.4238 1
Schistosoma mansoni tubulin subunit beta 0.0045 0.0084 0.0124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.073 0.1145
Loa Loa (eye worm) hypothetical protein 0.0032 0.004 0.008
Brugia malayi G protein-coupled receptor F59B2.13 0.0225 0.073 0.1721
Echinococcus multilocularis membrane bound transcription factor site 1 0.0055 0.0123 0.0117
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0225 0.073 0.0724
Schistosoma mansoni neuropeptide receptor 0.0225 0.073 0.1145
Echinococcus granulosus ring and YY1 binding protein 0.0038 0.0062 0.0056
Brugia malayi Transforming growth factor beta like domain containing protein 0.0032 0.004 0.0094
Brugia malayi hypothetical protein 0.0225 0.073 0.1721
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0225 0.073 0.1145
Schistosoma mansoni ephrin receptor 0.0208 0.0669 0.1049
Echinococcus granulosus neuropeptide receptor 0.0225 0.073 0.0724
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Loa Loa (eye worm) proprotein convertase 2 0.0306 0.1021 0.2398
Schistosoma mansoni hypothetical protein 0.0225 0.073 0.1145
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0742 0.2586 1
Chlamydia trachomatis SWIB complex protein 0.0108 0.0311 0.5
Loa Loa (eye worm) TK/EPH protein kinase 0.0264 0.087 0.2042
Toxoplasma gondii subtilisin SUB2 0.0055 0.0123 0.2451
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Onchocerca volvulus 0.0225 0.073 0.2645
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0225 0.073 0.1721
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0225 0.073 0.0724
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0525 0.176
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0054 0.0117 0.0426
Schistosoma mansoni growth hormone secretagogue receptor 0.0225 0.073 0.1145
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0225 0.073 0.0724
Toxoplasma gondii beta-tubulin, putative 0.0045 0.0084 0.0918
Echinococcus granulosus tyrosine protein kinase Lyn 0.0041 0.0071 0.0065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.073 0.1145
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.0839 0.1981
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0839 0.3018
Schistosoma mansoni hypothetical protein 0.0225 0.073 0.1145
Echinococcus multilocularis dro:myosuppressin receptor 0.0225 0.073 0.0724
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Echinococcus granulosus tubulin beta 1 chain 0.0045 0.0084 0.0079
Schistosoma mansoni neuropeptide F-like receptor 0.0225 0.073 0.1145
Echinococcus multilocularis dnaJ subfamily B 0.041 0.1395 0.139
Loa Loa (eye worm) TK protein kinase 0.0037 0.0057 0.0121
Brugia malayi beta-tubulin, identical 0.0045 0.0084 0.0199
Echinococcus granulosus hypothetical protein 0.0225 0.073 0.0724
Toxoplasma gondii subtilisin SUB4 0.0055 0.0123 0.2451
Schistosoma mansoni biogenic amine (5HT) receptor 0.0225 0.073 0.1145
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0525 0.176
Echinococcus granulosus g protein coupled receptor 0.0225 0.073 0.0724
Echinococcus granulosus 7TM GPCR rhodopsin 0.0225 0.073 0.0724
Trichomonas vaginalis conserved hypothetical protein 0.025 0.0823 0.295
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0306 0.1021 0.3744
Brugia malayi putative neuropeptide receptor 0.0225 0.073 0.1721
Loa Loa (eye worm) hypothetical protein 0.0186 0.0591 0.1383
Brugia malayi hypothetical protein 0.0225 0.073 0.1721
Onchocerca volvulus 0.0225 0.073 0.2645
Echinococcus granulosus allatostatin A receptor 0.079 0.2758 0.2754
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Echinococcus multilocularis serotonin receptor 0.0225 0.073 0.0724
Brugia malayi YY1-associated factor 2 0.0038 0.0062 0.0145
Schistosoma mansoni opsin-like receptor 0.0225 0.073 0.1145
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0066 0.016 0.0847
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Echinococcus multilocularis Tubulin beta 2C chain 0.0045 0.0084 0.0079
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Toxoplasma gondii beta tubulin 0.0045 0.0084 0.0918
Brugia malayi protein-tyrosine kinase 0.0037 0.0057 0.0135
Echinococcus multilocularis tubulin beta 1 chain 0.0045 0.0084 0.0079
Schistosoma mansoni neuropeptide f receptor 76f 0.0225 0.073 0.1145
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0225 0.073 0.0724
Echinococcus multilocularis rhodopsin orphan GPCR 0.0225 0.073 0.0724
Brugia malayi G-protein coupled receptor 0.0225 0.073 0.1721
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.025 0.0823 0.295
Schistosoma mansoni biogenic amine receptor 0.0225 0.073 0.1145
Echinococcus multilocularis rhodopsin orphan GPCR 0.0225 0.073 0.0724
Brugia malayi G-protein coupled receptor 0.0225 0.073 0.1721
Plasmodium falciparum subtilisin-like protease 3 0.0055 0.0123 0.2451
Onchocerca volvulus 0.0032 0.004 0.0145
Schistosoma mansoni amine GPCR 0.0225 0.073 0.1145
Schistosoma mansoni opsin-like receptor 0.0225 0.073 0.1145
Loa Loa (eye worm) LjBmp2/4b 0.0032 0.004 0.008
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0225 0.073 0.0724
Brugia malayi hypothetical protein 0.0225 0.073 0.1721
Onchocerca volvulus 0.0036 0.0054 0.0195
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0108 0.0311 1
Echinococcus multilocularis tubulin subunit beta 0.0045 0.0084 0.0079
Loa Loa (eye worm) tubulin beta-1 chain 0.0045 0.0084 0.0185
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0225 0.073 0.0724
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Echinococcus granulosus rhodopsin orphan GPCR 0.0225 0.073 0.0724
Schistosoma mansoni amine GPCR 0.0225 0.073 0.1145
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Toxoplasma gondii subtilisin SUB8 0.0055 0.0123 0.2451
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0047
Echinococcus multilocularis Tubulin beta 2C chain 0.0045 0.0084 0.0079
Schistosoma mansoni neuropeptide receptor 0.0225 0.073 0.1145
Schistosoma mansoni tubulin subunit beta 0.0045 0.0084 0.0124
Schistosoma mansoni hypothetical protein 0.0166 0.0519 0.0812
Brugia malayi hypothetical protein 0.0225 0.073 0.1721
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0225 0.073 0.0724
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0041 0.0071 0.0065
Brugia malayi Protein kinase domain containing protein 0.0026 0.0018 0.0042
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0041 0.0071 0.0065
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0364 0.1229 0.29
Loa Loa (eye worm) tubulin beta-2A chain 0.0045 0.0084 0.0185
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Schistosoma mansoni myosin xvIII 0.0225 0.073 0.1145
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Schistosoma mansoni serine-type protease inhibitor 0.1784 0.6326 1
Trichomonas vaginalis conserved hypothetical protein 0.025 0.0823 0.295
Echinococcus multilocularis neuropeptide FF receptor 2 0.0684 0.2378 0.2374
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0225 0.073 0.1145
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0742 0.2586 0.2582
Schistosoma mansoni RNA binding protein 0.0038 0.0062 0.0088
Loa Loa (eye worm) BEN-1 protein 0.0045 0.0084 0.0185
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.073 0.1145
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Schistosoma mansoni tyrosine kinase 0.0041 0.0071 0.0102
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0225 0.073 0.0724
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.073 0.171
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0123 0.0153
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0055 0.0123 0.0289
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0225 0.073 0.0724
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0038 0.0062 0.0145
Brugia malayi proprotein convertase 2 0.0766 0.2673 0.6307
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Echinococcus multilocularis sex peptide receptor 0.0225 0.073 0.0724
Schistosoma mansoni brg-1 associated factor 0.0108 0.0311 0.0482
Echinococcus multilocularis rhodopsin orphan GPCR 0.0225 0.073 0.0724
Echinococcus granulosus Tubulin beta 2C chain 0.0045 0.0084 0.0079
Echinococcus multilocularis segment polarity protein dishevelled 0.0094 0.0262 0.0256
Echinococcus granulosus tyrosine protein kinase HCK 0.0033 0.0043 0.0037
Echinococcus multilocularis neuropeptide receptor A26 0.0225 0.073 0.0724
Brugia malayi AKH receptor 0.0225 0.073 0.1721
Echinococcus granulosus Tubulin beta 2C chain 0.0045 0.0084 0.0079
Echinococcus granulosus neuropeptide receptor A26 0.0225 0.073 0.0724
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0108 0.0311 1
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0557 0.1889
Echinococcus granulosus dnaJ subfamily B 0.041 0.1395 0.139
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Onchocerca volvulus 0.0225 0.073 0.2645
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0225 0.073 0.1145
Toxoplasma gondii beta-1 tubulin, putative 0.0045 0.0084 0.0918
Schistosoma mansoni peptide (allatostatin)-like receptor 0.079 0.2758 0.4355
Brugia malayi putative neuropeptide receptor NPR1 0.0225 0.073 0.1721
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0525 0.176
Toxoplasma gondii subtilisin SUB12 0.0055 0.0123 0.2451
Echinococcus multilocularis Tubulin beta 2C chain 0.0045 0.0084 0.0079
Brugia malayi hypothetical protein 0.0032 0.004 0.0094
Loa Loa (eye worm) neuropeptide F receptor 0.0225 0.073 0.171
Loa Loa (eye worm) TK/ALK protein kinase 0.0026 0.0018 0.0028
Onchocerca volvulus 0.0038 0.0062 0.0223
Loa Loa (eye worm) hypothetical protein 0.0032 0.004 0.008
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0525 0.176
Echinococcus granulosus rhodopsin orphan GPCR 0.0225 0.073 0.0724
Trypanosoma brucei C-8 sterol isomerase, putative 0.0364 0.1229 0.3361
Schistosoma mansoni biogenic amine receptor 0.0225 0.073 0.1145
Schistosoma mansoni hypothetical protein 0.0038 0.0062 0.0088
Brugia malayi brahma associated protein 60 kDa 0.0108 0.0311 0.0733
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0839 0.3018
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Echinococcus granulosus G protein coupled receptor 139 0.0225 0.073 0.0724
Echinococcus multilocularis tgf beta family 0.0032 0.004 0.0034
Echinococcus multilocularis neuropeptide receptor 0.0225 0.073 0.0724
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0225 0.073 0.1145
Echinococcus granulosus neuropeptides capa receptor 0.0225 0.073 0.0724
Echinococcus multilocularis g protein coupled receptor 0.0225 0.073 0.0724
Loa Loa (eye worm) tubulin beta chain 0.0045 0.0084 0.0185
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.073 0.1145
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Echinococcus multilocularis neuropeptides capa receptor 0.0225 0.073 0.0724
Echinococcus granulosus tgf beta family 0.0032 0.004 0.0034
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0525 0.1903
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0108 0.0311 1
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0055 0.0123 0.0289
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1203 0.4238 0.6697
Loa Loa (eye worm) G-protein coupled receptor 0.0225 0.073 0.171
Plasmodium falciparum tubulin beta chain 0.0045 0.0084 0.0918
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0108 0.0311 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.0055 0.0123 0.0185
Brugia malayi Melatonin receptor type 1A 0.0225 0.073 0.1721
Loa Loa (eye worm) melatonin receptor type 1A 0.0225 0.073 0.171
Schistosoma mansoni hypothetical protein 0.1007 0.3535 0.5585
Echinococcus multilocularis SWI:SNF matrix associated 0.0108 0.0311 0.0305
Echinococcus granulosus tyrosine protein kinase Src42A 0.0041 0.0071 0.0065
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Echinococcus granulosus serotonin receptor 0.0225 0.073 0.0724
Loa Loa (eye worm) hypothetical protein 0.0094 0.0262 0.0606
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Loa Loa (eye worm) hypothetical protein 0.0038 0.0062 0.0131
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Loa Loa (eye worm) hypothetical protein 0.0684 0.2378 0.5606
Brugia malayi follicle stimulating hormone receptor 0.0225 0.073 0.1721
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0839 0.3018
Echinococcus granulosus segment polarity protein dishevelled 0.0094 0.0262 0.0256
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Echinococcus granulosus 7tm_1 domain containing protein 0.0225 0.073 0.0724
Echinococcus multilocularis neuropeptide Y receptor 0.0225 0.073 0.0724
Brugia malayi G protein-coupled receptor 0.0225 0.073 0.1721
Echinococcus multilocularis segment polarity protein dishevelled 0.0094 0.0262 0.0256
Loa Loa (eye worm) BEN-1 protein 0.0045 0.0084 0.0185
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Trypanosoma brucei subtilisin peptidase 0.0055 0.0123 0.0176
Echinococcus granulosus tubulin beta 4A class IVa 0.0045 0.0084 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0123 0.0153
Echinococcus granulosus rhodopsin orphan GPCR 0.0225 0.073 0.0724
Leishmania major subtilisin-like serine peptidase 0.0055 0.0123 0.0523
Trypanosoma brucei beta tubulin 0.0045 0.0084 0.0066
Brugia malayi Dopamine receptor protein 2 0.0225 0.073 0.1721
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0839 0.3018
Echinococcus multilocularis Furin 1 0.0306 0.1021 0.1016
Brugia malayi Dopamine receptor protein 1 0.0225 0.073 0.1721
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0108 0.0311 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0145 0.0445 0.1037
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Schistosoma mansoni apoptosis regulator bax 0.0166 0.0519 0.0812
Echinococcus granulosus neuropeptide s receptor 0.0225 0.073 0.0724
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0225 0.073 0.0724
Brugia malayi hypothetical protein 0.0225 0.073 0.1721
Loa Loa (eye worm) hypothetical protein 0.0038 0.0062 0.0131
Echinococcus granulosus neuropeptide FF receptor 2 0.0684 0.2378 0.2374
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0225 0.073 0.1721
Onchocerca volvulus 0.0225 0.073 0.2645
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Echinococcus granulosus biogenic amine 5HT receptor 0.0225 0.073 0.0724
Brugia malayi Tachykinin-like peptides receptor 99D 0.0684 0.2378 0.5612
Echinococcus granulosus tyrosine protein kinase Blk 0.0037 0.0057 0.0051
Echinococcus multilocularis Tubulin beta 2C chain 0.0045 0.0084 0.0079
Onchocerca volvulus 0.0032 0.004 0.0145
Toxoplasma gondii subtilisin SUB10 0.0055 0.0123 0.2451
Echinococcus multilocularis ring and YY1 binding protein 0.0038 0.0062 0.0056
Onchocerca volvulus 0.0225 0.073 0.2645
Onchocerca volvulus 0.0225 0.073 0.2645
Echinococcus multilocularis beta tubulin 0.0045 0.0084 0.0079
Echinococcus granulosus alpha 1A adrenergic receptor 0.0225 0.073 0.0724
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0041 0.0071 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.025 0.0823 0.295
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.0311 0.0904
Toxoplasma gondii subtilisin SUB5 0.0055 0.0123 0.2451
Schistosoma mansoni amine GPCR 0.0225 0.073 0.1145
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0094 0.0262 0.0619
Echinococcus granulosus neuropeptide receptor 0.0225 0.073 0.0724
Echinococcus multilocularis allatostatin A receptor 0.079 0.2758 0.2754
Echinococcus granulosus segment polarity protein dishevelled 0.0094 0.0262 0.0256
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0055 0.0123 0.5
Onchocerca volvulus 0.0038 0.0062 0.0223
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0225 0.073 0.0724
Schistosoma mansoni hypothetical protein 0.0225 0.073 0.1145
Echinococcus granulosus rhodopsin orphan GPCR 0.0225 0.073 0.0724
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Echinococcus granulosus Zinc finger RanBP2 type 0.0038 0.0062 0.0056
Onchocerca volvulus 0.079 0.2758 1
Trichomonas vaginalis conserved hypothetical protein 0.025 0.0823 0.295
Loa Loa (eye worm) hypothetical protein 0.0204 0.0657 0.1538
Loa Loa (eye worm) SRC-1 0.0041 0.0071 0.0153
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0525 0.176
Plasmodium falciparum subtilisin-like protease 1 0.0055 0.0123 0.2451
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0166 0.0519 0.0513
Plasmodium vivax subtilisin-like protease 1 0.0055 0.0123 0.1688
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0225 0.073 0.1145
Brugia malayi endoprotease bli-4 precursor 0.1203 0.4238 1
Echinococcus multilocularis neuroendocrine convertase 2 0.0766 0.2673 0.2669
Leishmania major C-8 sterol isomerase-like protein 0.0364 0.1229 1
Schistosoma mansoni histamine h1 receptor 0.0225 0.073 0.1145
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.025 0.0823 0.295
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Echinococcus multilocularis somatostatin receptor 0.0225 0.073 0.0724
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0225 0.073 0.1721
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.073 0.1145
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Schistosoma mansoni hypothetical protein 0.041 0.1395 0.2198
Brugia malayi brahma associated protein 60 kDa 0.0108 0.0311 0.0733
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0038 0.0062 0.0056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Brugia malayi neuropeptide F receptor 0.0225 0.073 0.1721
Toxoplasma gondii subtilisin SUB6 0.0055 0.0123 0.2451
Echinococcus multilocularis 0.0952 0.334 0.3336
Echinococcus multilocularis epidermal growth factor receptor 0.0145 0.0445 0.0439
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0041 0.0071 0.0065
Schistosoma mansoni tgf-beta family 0.0032 0.004 0.0054
Loa Loa (eye worm) subtilase 0.0055 0.0123 0.0276
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0311 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0225 0.073 0.0724
Onchocerca volvulus 0.0055 0.0123 0.0445
Brugia malayi SWIB/MDM2 domain containing protein 0.0108 0.0311 0.0733
Brugia malayi Tubulin beta-1 chain 0.0045 0.0084 0.0199
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0166 0.0519 0.0513
Brugia malayi larval opioid receptor 0.0225 0.073 0.1721
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0225 0.073 0.0724
Trypanosoma cruzi beta tubulin, putative 0.0045 0.0084 0.0196
Echinococcus granulosus tubulin subunit beta 0.0045 0.0084 0.0079
Onchocerca volvulus 0.0225 0.073 0.2645
Echinococcus granulosus g protein coupled receptor 0.0225 0.073 0.0724
Trypanosoma brucei beta tubulin 0.0045 0.0084 0.0066
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0225 0.073 0.0724
Onchocerca volvulus 0.0031 0.0034 0.0122
Echinococcus granulosus fmrfamide receptor 0.0225 0.073 0.0724
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0071 0.0065
Schistosoma mansoni neuropeptide receptor 0.0225 0.073 0.1145
Echinococcus multilocularis g protein coupled receptor 0.0225 0.073 0.0724
Mycobacterium leprae Possible secreted protease 0.0055 0.0123 0.5
Echinococcus multilocularis bone morphogenetic protein 2 0.0032 0.004 0.0034
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0225 0.073 0.1145
Echinococcus granulosus orexin receptor type 2 0.0225 0.073 0.0724
Onchocerca volvulus 0.0225 0.073 0.2645
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0071 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0525 0.176
Echinococcus multilocularis SWI:SNF matrix associated 0.0108 0.0311 0.0305
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0008 0.0003
Onchocerca volvulus 0.0108 0.0311 0.1126
Brugia malayi hypothetical protein 0.0225 0.073 0.1721
Brugia malayi neuroendocrine convertase 1 precursor 0.0766 0.2673 0.6307
Echinococcus granulosus neuroendocrine convertase 2 0.0766 0.2673 0.2669
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0041 0.0071 0.0065
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0306 0.1021 0.1606
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0839 0.3018
Echinococcus granulosus g protein coupled receptor 0.0225 0.073 0.0724
Schistosoma mansoni amine GPCR 0.0225 0.073 0.1145
Echinococcus multilocularis neuropeptide Y receptor 0.0225 0.073 0.0724
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Echinococcus granulosus dro:myosuppressin receptor 0.0225 0.073 0.0724
Echinococcus multilocularis fmrfamide receptor 0.0225 0.073 0.0724
Plasmodium vivax subtilisin-like protease 2, putative 0.0055 0.0123 0.1688
Entamoeba histolytica tubulin family protein 0.0045 0.0084 1
Echinococcus granulosus neuropeptide Y receptor 0.0225 0.073 0.0724
Brugia malayi ORL1-like opioid receptor 0.0225 0.073 0.1721
Schistosoma mansoni biogenic amine (5HT) receptor 0.0225 0.073 0.1145
Echinococcus multilocularis tyrosine protein kinase Blk 0.0037 0.0057 0.0051
Loa Loa (eye worm) TK protein kinase 0.0033 0.0043 0.0088
Echinococcus granulosus beta tubulin 0.0045 0.0084 0.0079
Brugia malayi neuropeptide F receptor 0.0225 0.073 0.1721
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0225 0.073 0.1145
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0055 0.0123 0.5
Toxoplasma gondii subtilisin SUB7 0.0055 0.0123 0.2451
Onchocerca volvulus 0.0038 0.0062 0.0223
Echinococcus granulosus beta tubulin 0.0045 0.0084 0.0079
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Brugia malayi hypothetical protein 0.0225 0.073 0.1721
Echinococcus granulosus SWI:SNF matrix associated 0.0108 0.0311 0.0305
Brugia malayi Dopamine receptor 0.0225 0.073 0.1721
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.073 0.1145
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Trichomonas vaginalis conserved hypothetical protein 0.025 0.0823 0.295
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Echinococcus granulosus rhodopsin orphan GPCR 0.0225 0.073 0.0724
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0041 0.0071 0.0065
Echinococcus multilocularis zinc finger protein Ran binding 0.0038 0.0062 0.0056
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0055 0.0123 0.0117
Schistosoma mansoni dishevelled 0.0094 0.0262 0.0406
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.073 0.1145
Echinococcus multilocularis Tubulin beta 2C chain 0.0045 0.0084 0.0079
Onchocerca volvulus 0.0225 0.073 0.2645
Trypanosoma brucei beta tubulin 0.0045 0.0084 0.0066
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0225 0.073 0.1145
Schistosoma mansoni zinc finger protein 0.0038 0.0062 0.0088
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.0071 0.0065
Echinococcus granulosus tyrosine protein kinase Src64B 0.0041 0.0071 0.0065
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0225 0.0732 0.1149
Echinococcus granulosus tachykinin peptides receptor 99D 0.0225 0.073 0.0724
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0225 0.073 0.171
Loa Loa (eye worm) neuropeptide F receptor 0.0225 0.073 0.171
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0055 0.0123 0.5
Schistosoma mansoni site-1 peptidase (S08 family) 0.0055 0.0123 0.0185
Echinococcus multilocularis beta tubulin 0.0045 0.0084 0.0079
Brugia malayi ephrin receptor 1 precursor 0.01 0.0282 0.0664
Echinococcus granulosus tyrosine kinase 0.0037 0.0057 0.0051
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0037 0.0057 0.0051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0055 0.0123 0.5
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0557 0.1889
Trypanosoma cruzi subtilisin peptidase 0.0055 0.0123 0.0523
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0306 0.1021 0.3744
Echinococcus granulosus neuropeptide Y receptor 0.0225 0.073 0.0724
Echinococcus granulosus tm gpcr rhodopsin 0.0225 0.073 0.0724
Onchocerca volvulus 0.0204 0.0657 0.2383
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0055 0.0123 0.5
Echinococcus granulosus zinc finger protein Ran binding 0.0038 0.0062 0.0056
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0066 0.016 0.0285
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0055 0.0123 0.0117
Echinococcus granulosus neuropeptides capa receptor 0.0225 0.073 0.0724
Echinococcus granulosus biogenic amine 5HT receptor 0.0225 0.073 0.0724
Toxoplasma gondii subtilisin SUB9 0.0055 0.0123 0.2451
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0225 0.073 0.0724
Brugia malayi hypothetical protein 0.0032 0.004 0.0094
Loa Loa (eye worm) hypothetical protein 0.0038 0.0062 0.0131
Loa Loa (eye worm) hypothetical protein 0.0104 0.0297 0.0688
Echinococcus granulosus sex peptide receptor 0.0225 0.073 0.0724
Onchocerca volvulus 0.0225 0.073 0.2645
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Loa Loa (eye worm) hypothetical protein 0.0038 0.0062 0.0131
Echinococcus granulosus Tubulin beta 2C chain 0.0045 0.0084 0.0079
Echinococcus multilocularis SWI:SNF matrix associated 0.0108 0.0311 0.0305
Echinococcus granulosus tyrosine protein kinase Src42A 0.0034 0.0045 0.0039
Schistosoma mansoni hypothetical protein 0.0166 0.0519 0.0812
Schistosoma mansoni hypothetical protein 0.025 0.0823 0.1292
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0123 0.0153
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.0071 0.0065
Loa Loa (eye worm) beta-tubulin 0.0045 0.0084 0.0185
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0225 0.073 0.0724
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0225 0.073 0.2645
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0166 0.0519 0.1225
Loa Loa (eye worm) hypothetical protein 0.0166 0.0519 0.1212
Plasmodium vivax subtilisin-like serine protease, putative 0.0055 0.0123 0.1688
Onchocerca volvulus 0.0225 0.073 0.2645
Echinococcus granulosus furin 0.1203 0.4238 0.4235
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0225 0.073 0.1145
Echinococcus multilocularis rhodopsin orphan GPCR 0.0225 0.073 0.0724
Loa Loa (eye worm) G-protein coupled receptor 0.0225 0.073 0.171
Loa Loa (eye worm) hypothetical protein 0.0038 0.0062 0.0131
Trypanosoma brucei RNA helicase, putative 0.1007 0.3535 1
Onchocerca volvulus 0.0225 0.073 0.2645
Schistosoma mansoni dishevelled 0.0084 0.0227 0.0349
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0225 0.073 0.1145
Chlamydia trachomatis DNA topoisomerase I 0.0108 0.0311 0.5
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0038 0.0062 0.0145
Echinococcus granulosus Tubulin beta 2C chain 0.0045 0.0084 0.0079
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0108 0.0311 0.072
Schistosoma mansoni hypothetical protein 0.0108 0.0311 0.0482
Toxoplasma gondii subtilisin SUB1 0.0055 0.0123 0.2451
Trypanosoma brucei beta tubulin 0.0045 0.0084 0.0066
Brugia malayi Serotonin receptor 0.0225 0.073 0.1721
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0055 0.0123 0.0185
Echinococcus multilocularis neuropeptide receptor 0.0225 0.073 0.0724
Schistosoma mansoni hypothetical protein 0.0108 0.0311 0.0482
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0038 0.0062 0.0223
Brugia malayi Transforming growth factor beta like domain containing protein 0.0126 0.0377 0.0889
Brugia malayi hypothetical protein 0.0023 0.0006 0.0014
Giardia lamblia High cysteine membrane protein Group 2 0.0436 0.1489 1
Brugia malayi hypothetical protein 0.0225 0.073 0.1721
Echinococcus granulosus tm gpcr rhodopsin 0.0225 0.073 0.0724
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0055 0.0123 0.0523
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0839 0.3018
Loa Loa (eye worm) hypothetical protein 0.0364 0.1229 0.289
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0038 0.0062 0.0145
Echinococcus granulosus bone morphogenetic protein 2 0.0032 0.004 0.0034
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0041 0.0071 0.0065
Loa Loa (eye worm) bone morphogenic protein 6 0.0126 0.0377 0.0876
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0166 0.0519 0.0812
Schistosoma mansoni opsin-like receptor 0.0225 0.073 0.1145
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Schistosoma mansoni tubulin subunit beta 0.0045 0.0084 0.0124
Brugia malayi Serotonin receptor 0.0225 0.073 0.1721
Trichomonas vaginalis conserved hypothetical protein 0.025 0.0823 0.295
Schistosoma mansoni tyrosine kinase 0.0041 0.0071 0.0102
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0225 0.073 0.1145
Echinococcus granulosus rhodopsin orphan GPCR 0.0225 0.073 0.0724
Echinococcus multilocularis tyrosine protein kinase HCK 0.0033 0.0043 0.0037
Echinococcus granulosus Tubulin beta 2C chain 0.0045 0.0084 0.0079
Echinococcus multilocularis G protein coupled receptor 139 0.0225 0.073 0.0724
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0108 0.0311 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.025 0.0823 0.295
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1238 0.4367 0.6901
Schistosoma mansoni tubulin subunit beta 0.0045 0.0084 0.0124
Echinococcus multilocularis rhodopsin orphan GPCR 0.0225 0.073 0.0724
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0306 0.1021 0.3744
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0166 0.0519 0.0513
Schistosoma mansoni amine GPCR 0.0225 0.073 0.1145
Onchocerca volvulus 0.0225 0.073 0.2645
Schistosoma mansoni biogenic amine receptor 0.0225 0.073 0.1145
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Loa Loa (eye worm) tubulin beta-4 chain 0.0045 0.0084 0.0185
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.073 0.1145
Loa Loa (eye worm) hypothetical protein 0.079 0.2758 0.6502
Loa Loa (eye worm) growth/differentiation factor 10 0.0032 0.004 0.008
Echinococcus multilocularis fmrfamide receptor 0.0225 0.073 0.0724
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0123 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0225 0.073 0.0724
Schistosoma mansoni hypothetical protein 0.0225 0.073 0.1145
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0126 0.0377 0.0371
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0225 0.073 0.1721
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0225 0.073 0.1145
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0055 0.0123 0.0185
Echinococcus granulosus epidermal growth factor receptor 0.0145 0.0445 0.0439
Brugia malayi sulfakinin receptor protein 0.0225 0.073 0.1721
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0023 0.0008 0.0003
Schistosoma mansoni hypothetical protein 0.0166 0.0519 0.0812
Loa Loa (eye worm) hypothetical protein 0.0055 0.0123 0.0276
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0225 0.073 0.0724
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0057 0.0051
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2809 1 1
Leishmania major beta tubulin 0.0045 0.0084 0.0196
Echinococcus multilocularis rhodopsin orphan GPCR 0.0225 0.073 0.0724
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0066 0.016 0.0847
Brugia malayi celfurPC protein 0.0952 0.334 0.788
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0225 0.073 0.1721
Brugia malayi Subtilase family protein 0.0055 0.0123 0.0289
Schistosoma mansoni alpha-1 adrenergic receptor 0.0225 0.073 0.1145
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0742 0.2586 1
Schistosoma mansoni TRABID protein (C64 family) 0.0038 0.0062 0.0088
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0225 0.073 0.171
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0225 0.073 0.0724
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0225 0.073 0.171
Trichomonas vaginalis conserved hypothetical protein 0.025 0.0823 0.295
Echinococcus multilocularis tyrosine protein kinase Srms 0.0037 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0225 0.073 0.171
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0034 0.0045 0.0039
Schistosoma mansoni hypothetical protein 0.0108 0.0311 0.0482
Onchocerca volvulus 0.0023 0.0006 0.0022
Echinococcus multilocularis g protein coupled receptor 0.0225 0.073 0.0724
Echinococcus granulosus Furin 1 0.0306 0.1021 0.1016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0055 0.0123 0.5
Onchocerca volvulus 0.0225 0.073 0.2645
Echinococcus granulosus g-protein coupled receptor 0.0225 0.073 0.0724
Brugia malayi hypothetical protein 0.0225 0.073 0.1721
Loa Loa (eye worm) brahma associated protein 0.0108 0.0311 0.072
Echinococcus multilocularis g-protein coupled receptor 0.0225 0.073 0.0724
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0225 0.073 0.1145
Schistosoma mansoni tgf-beta family 0.0032 0.004 0.0054
Echinococcus multilocularis G-protein coupled receptor, putative 0.0225 0.073 0.0724
Echinococcus multilocularis neuropeptides capa receptor 0.0225 0.073 0.0724
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0055 0.0123 0.5
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0038 0.0062 0.0056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0055 0.0123 0.0153
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0055 0.0123 0.5
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Echinococcus multilocularis orexin receptor type 2 0.0225 0.073 0.0724
Brugia malayi GnHR receptor homolog 0.0225 0.073 0.1721
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0041 0.0071 0.0065
Echinococcus multilocularis serotonin receptor 0.0225 0.073 0.0724
Loa Loa (eye worm) hypothetical protein 0.0225 0.073 0.171
Schistosoma mansoni fusion 0.0038 0.0062 0.0088

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 21 % Inhibition at 50 uM on cAMP production induced by 50 uM 5`-(N-ethylcarboxamido)adenosine in CHO cell line transfected with human Adenosine A2B receptor cDNA ChEMBL. 9667972
Inhibition (binding) = 21 % Inhibition at 50 uM on cAMP production induced by 50 uM 5`-(N-ethylcarboxamido)adenosine in CHO cell line transfected with human Adenosine A2B receptor cDNA ChEMBL. 9667972
Ki (binding) = 42.5 nM Binding affinity at cloned human adenosine A3 receptor expressed in HEK-293 cells was determined using [125I]-AB-MECA as radioligand ChEMBL. 9667972
Ki (binding) = 42.5 nM Binding affinity at cloned human adenosine A3 receptor expressed in HEK-293 cells was determined using [125I]-AB-MECA as radioligand ChEMBL. 9667972
Ki (binding) = 200 nM Binding affinity was determined in radioligand binding assay at rat striatal Adenosine A2A receptor vs [3H]-CGS- 21680 ChEMBL. 9667972
Ki (binding) = 200 nM Binding affinity was determined in radioligand binding assay at rat striatal Adenosine A2A receptor vs [3H]-CGS- 21680 ChEMBL. 9667972
Ki (binding) = 1200 nM Binding affinity was determined in radioligand binding assay at rat brain adenosine A1 receptor vs [3H]-R-PIA ChEMBL. 9667972
Ki (binding) = 1200 nM Binding affinity was determined in radioligand binding assay at rat brain adenosine A1 receptor vs [3H]-R-PIA ChEMBL. 9667972
Selectivity ratio (binding) = 4.7 Ratio against rat A2A receptor and Human A3 receptor ChEMBL. 9667972
Selectivity ratio (binding) = 28 Ratio against rat A1 receptor and Human A3 receptor ChEMBL. 9667972

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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