Detailed information for compound 1611409

Basic information

Technical information
  • TDR Targets ID: 1611409
  • Name: (2-(1,3-Benzodioxol-5-yl)-2-(benzylthio)ethyl )(hydroxy)azane oxide
  • MW: 317.36 | Formula: C16H15NO4S
  • H donors: 0 H acceptors: 2 LogP: 3.51 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)CC(c1ccc2c(c1)OCO2)SCc1ccccc1
  • InChi: 1S/C16H15NO4S/c18-17(19)9-16(22-10-12-4-2-1-3-5-12)13-6-7-14-15(8-13)21-11-20-14/h1-8,16H,9-11H2
  • InChiKey: SEQGYDSVNJWFHM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(1,3-benzodioxol-5-yl)-N-hydroxy-2-(phenylmethylsulfanyl)ethanamine oxide
  • 2-(1,3-benzodioxol-5-yl)-N-hydroxy-2-(phenylmethylthio)ethanamine oxide
  • 2-(1,3-benzodioxol-5-yl)-2-(benzylthio)-N-hydroxy-ethanamine oxide
  • 5-[1-(benzylthio)-2-nitro-ethyl]-1,3-benzodioxole
  • 5-[2-nitro-1-(phenylmethylsulfanyl)ethyl]-1,3-benzodioxole
  • 5-[2-nitro-1-(phenylmethylthio)ethyl]-1,3-benzodioxole
  • AIDS-143459
  • AIDS143459
  • N-[2-(1,3-benzodioxol-5-yl)-2-(phenylmethylsulfanyl)ethyl]-N-oxidohydroxylamine
  • N-[2-(1,3-benzodioxol-5-yl)-2-(phenylmethylsulfanyl)ethyl]-N-oxido-hydroxylamine
  • N-[2-(1,3-benzodioxol-5-yl)-2-(phenylmethylthio)ethyl]-N-oxidohydroxylamine
  • N-[2-(1,3-benzodioxol-5-yl)-2-(benzylthio)ethyl]-N-oxido-hydroxylamine
  • NCI60_022142
  • NSC664266

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0709 0.3496 0.3496
Schistosoma mansoni hypothetical protein 0.0183 0.0847 0.0847
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0015 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0183 0.0847 0.0847
Trichomonas vaginalis PIKK family atypical protein kinase 0.2 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0017
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0107 0.0464 0.0464
Loa Loa (eye worm) phosphatidylinositol 3 0.0139 0.0626 0.0626
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0017
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0158 0.0724 0.0724
Echinococcus multilocularis Zinc finger, PHD finger 0.0158 0.0724 0.0724
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.1698 0.8479 0.8479
Leishmania major phosphatidylinositol 3-kinase, putative 0.0158 0.0724 0.0724
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0017 0.0017
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0139 0.0626 0.0626
Echinococcus granulosus intermediate filament protein 0.0029 0.0073 0.0073
Entamoeba histolytica hypothetical protein 0.0286 0.1368 0.1367
Trichomonas vaginalis conserved hypothetical protein 0.0441 0.2147 0.2147
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0017
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0015 0.0001 0.0001
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0325 0.1566 0.1566
Trichomonas vaginalis PIKK family atypical protein kinase 0.1099 0.5461 0.5461
Trichomonas vaginalis PIKK family atypical protein kinase 0.1498 0.7472 0.7472
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.1599 0.7981 0.7981
Onchocerca volvulus 0.0018 0.0017 0.0279
Entamoeba histolytica protein kinase rad3, putative 0.0396 0.1922 0.1922
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0158 0.0724 0.0724
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0139 0.0626 0.0626
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.1196 0.5951 0.5951
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0538 0.2637 0.2637
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0175 0.0175
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0017 0.0017
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0015 0.0001 0.0001
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.011 0.0483 0.0483
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0029 0.0073 0.0073
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.039 0.1892 0.1892
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0107 0.0464 0.0464
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0325 0.1566 0.1566
Loa Loa (eye worm) phosphatidylinositol 3 0.0456 0.2221 0.2221
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0265 0.1262 0.1262
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0139 0.0626 0.0626
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0175 0.0175
Leishmania major cathepsin L-like protease 0.0018 0.0017 0.0017
Schistosoma mansoni intermediate filament proteins 0.0029 0.0073 0.0073
Onchocerca volvulus 0.0018 0.0017 0.0279
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0199 0.0199
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0257 0.0257
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0015 0.0001 0.5
Echinococcus granulosus dnaJ subfamily B 0.0441 0.2148 0.2148
Toxoplasma gondii cathepsin CPL 0.0018 0.0017 0.0023
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0198 0.0921 0.0921
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0175 0.0175
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0017
Plasmodium vivax vivapain-2 0.0018 0.0017 0.0242
Onchocerca volvulus 0.0018 0.0017 0.0279
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0257 0.1222 0.1222
Schistosoma mansoni hypothetical protein 0.0139 0.0626 0.0626
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0158 0.0724 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0107 0.0464 0.0464
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0015 0.0001 0.0001
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0107 0.0464 0.0464
Leishmania major cathepsin L-like protease 0.0069 0.0273 0.0273
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0495 0.2418 0.2418
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0273 0.0273
Leishmania major cathepsin L-like protease 0.0018 0.0017 0.0017
Loa Loa (eye worm) ctsf protein 0.0018 0.0017 0.0017
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0073 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0698 0.3443 0.3443
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0107 0.0464 0.0464
Brugia malayi Cathepsin L-like precursor 0.0018 0.0017 0.0017
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0748 0.3691 0.3691
Trichomonas vaginalis immunophilin, putative 0.0107 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0399 0.1937 0.1937
Echinococcus multilocularis fk506 binding protein 0.0107 0.0464 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0407 0.1975 0.1975
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0015 0.0001 0.0001
Giardia lamblia GTOR 0.2 1 1
Leishmania major cathepsin L-like protease 0.0018 0.0017 0.0017
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0073 0.0073
Toxoplasma gondii FATC domain-containing protein 0.0396 0.1922 0.2572
Leishmania major phosphatidylinositol kinase related protein, putative 0.0139 0.0626 0.0626
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0748 0.3691 0.3691
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0059 0.0222 0.0222
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0139 0.0626 0.0626
Brugia malayi Cathepsin L-like precursor 0.0018 0.0017 0.0017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0175 0.0175
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0017 0.0017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0396 0.1922 0.1922
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0015 0.0001 0.0008
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0139 0.0626 0.0626
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0273 0.0273
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0107 0.0464 0.0464
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0139 0.0626 0.0626
Onchocerca volvulus 0.0018 0.0017 0.0279
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0218 0.1027 0.1026
Loa Loa (eye worm) hypothetical protein 0.0302 0.1447 0.1447
Schistosoma mansoni immunophilin 0.0107 0.0464 0.0464
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0325 0.1566 0.1566
Trichomonas vaginalis PIKK family atypical protein kinase 0.1099 0.5461 0.5461
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0396 0.1922 0.1922
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0032 0.0088 0.0088
Loa Loa (eye worm) phosphatidylinositol kinase 0.0139 0.0626 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.1498 0.7472 0.7472
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0107 0.0464 0.0464
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.2 1 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0022 0.0037 0.0037
Onchocerca volvulus 0.0139 0.0626 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0107 0.0464 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1196 0.5951 0.5951
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0198 0.0921 0.0921
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0265 0.1262 0.1262
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0325 0.1566 0.1566
Trichomonas vaginalis fk506-binding protein, putative 0.0107 0.0464 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.1097 0.5453 0.5453
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0139 0.0626 0.0626
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0158 0.0724 0.0968
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0396 0.1922 0.1922
Loa Loa (eye worm) fibroinase 0.0018 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.1196 0.5951 0.5951
Echinococcus multilocularis serine protein kinase ATM 0.0396 0.1922 0.1922
Leishmania major cathepsin L-like protease 0.0018 0.0017 0.0017
Echinococcus multilocularis cysteine protease 0.0018 0.0017 0.0017
Brugia malayi FAT domain containing protein 0.0302 0.1447 0.1447
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0037 0.0037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0175 0.0175
Onchocerca volvulus 0.0029 0.0073 0.1166
Schistosoma mansoni voltage-gated potassium channel 0.0121 0.0534 0.0534
Loa Loa (eye worm) cysteine protease 0.0018 0.0017 0.0017
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.2 1 1
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0015 0.0001 0.0001
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0017 0.0017
Brugia malayi CXXC zinc finger family protein 0.0031 0.0083 0.0083
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0015 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0228 0.1075 0.1075
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0158 0.0724 0.0724
Loa Loa (eye worm) hypothetical protein 0.0258 0.1225 0.1225
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0015 0.0001 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0037 0.0037
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0103 0.0446 0.0446
Echinococcus multilocularis 0.0139 0.0626 0.0626
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.2 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0222 0.0297
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0015 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.1498 0.7472 0.7472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0017
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0139 0.0626 0.8653
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0037 0.0037
Loa Loa (eye worm) phosphatidylinositol 3 0.0139 0.0626 0.0626
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.011 0.0483 0.0483
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1601 0.7989 0.7989
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0092 0.039 0.039
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0037 0.0037
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0017 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.0375 0.0375
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0396 0.1922 0.1922
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0017
Entamoeba histolytica cysteine protease, putative 0.0018 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.1097 0.5453 0.5453
Trichomonas vaginalis PIKK family atypical protein kinase 0.12 0.5971 0.5971
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0158 0.0724 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0073 0.0073
Onchocerca volvulus 0.0029 0.0073 0.1166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0396 0.1922 0.1922
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0198 0.0921 0.0921
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0748 0.3691 0.3691
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0187 0.0866 0.0866
Mycobacterium leprae conserved hypothetical protein 0.0139 0.0626 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.2 1 1
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0031 0.0083 0.1318
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0037 0.0037
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0015 0.0001 0.0001
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0037 0.0037
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0139 0.0626 0.8653
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.039 0.1892 0.1892
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD) 0.0015 0.0001 0.0012
Schistosoma mansoni hypothetical protein 0.0441 0.2148 0.2148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0017
Brugia malayi intermediate filament protein 0.0029 0.0073 0.0073
Leishmania major fk506-binding protein 1-like protein 0.0107 0.0464 0.0464
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.011 0.0483 0.0483
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1601 0.7989 0.7989
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0017
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0842 0.4165 0.4165
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0139 0.0626 0.0626
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0092 0.039 0.039
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0698 0.3443 0.3443
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0158 0.0724 0.0724
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0015 0.0001 0.0001
Brugia malayi Cathepsin L-like precursor 0.0018 0.0017 0.0017
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0198 0.0921 0.0921
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0158 0.0724 0.0724
Leishmania major cathepsin L-like protease 0.0069 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0068 0.0268 0.0268
Trichomonas vaginalis PIKK family atypical protein kinase 0.2 1 1
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0015 0.0001 0.0001
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0017 0.0279
Schistosoma mansoni lamin 0.0029 0.0073 0.0073
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0325 0.1566 0.1566
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0198 0.0921 0.0921
Leishmania major phosphatidylinositol 3-kinase, putative 0.0698 0.3443 0.3443
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0175 0.0175
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0107 0.0464 0.6415
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.2 1 1
Schistosoma mansoni cpg binding protein 0.0033 0.0091 0.0091
Trichomonas vaginalis fk506-binding protein, putative 0.0015 0.0001 0.0001
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0032 0.0088 0.0088
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0022 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0017
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0139 0.0626 0.8653
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0018 0.0017 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0017
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0107 0.0464 0.0464
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0175 0.0175
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0017 0.0017
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.0626 0.0626
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0015 0.0001 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0302 0.1447 0.1447
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0139 0.0626 0.0626
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0022 0.0037 0.0037
Leishmania major cathepsin L-like protease 0.0018 0.0017 0.0017
Echinococcus granulosus potassium voltage gated channel subfamily H 0.011 0.0483 0.0483
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0015 0.0001 0.0001
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0158 0.0724 0.0724
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0273 0.0273
Echinococcus multilocularis lamin dm0 0.0029 0.0073 0.0073
Plasmodium vivax hypothetical protein 0.0139 0.0626 0.8653
Onchocerca volvulus 0.0015 0.0001 0.0009
Echinococcus multilocularis lamin 0.0029 0.0073 0.0073
Onchocerca volvulus 0.0015 0.0001 0.0009
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0139 0.0626 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0698 0.3443 0.3443
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0017
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0139 0.0626 0.0626
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0396 0.1922 0.1922
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0139 0.0626 0.8653
Loa Loa (eye worm) phosphatidylinositol 3 0.0059 0.0222 0.0222
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0139 0.0626 0.0838
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0015 0.0001 0.0001
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.2 1 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0017 0.0017
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0325 0.1566 0.1566
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0273 0.0273
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0018 0.0017 0.0279
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0273 0.0273
Brugia malayi Cathepsin L-like precursor 0.0018 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.1599 0.7981 0.7981
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0017 0.0242
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0169 0.0779 0.0779
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0939 0.4655 0.4655
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0103 0.0446 0.0446
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0258 0.1225 0.1225
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0107 0.0464 0.0464
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0158 0.0724 0.0968
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0441 0.2147 0.2873
Giardia lamblia Phosphatidylinositol 4-kinase 0.0139 0.0626 0.0626
Echinococcus granulosus geminin 0.0183 0.0847 0.0847
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.2 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0198 0.0921 0.0921
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0158 0.0724 0.0723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0017
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0037 0.0037
Echinococcus granulosus serine protein kinase ATM 0.0396 0.1922 0.1922
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0243 0.0243
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0139 0.0626 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0709 0.3496 0.3496
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0273 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.1099 0.5461 0.5461
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0198 0.0921 0.0921
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0139 0.0626 0.0626
Giardia lamblia Hypothetical protein 0.0015 0.0001 0.0001
Brugia malayi Cathepsin L-like precursor 0.0018 0.0017 0.0017
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0158 0.0724 0.0724
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0015 0.0001 0.0001
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0158 0.0724 0.0724
Leishmania major peptidylprolyl isomerase-like protein 0.0107 0.0464 0.0464
Entamoeba histolytica hypothetical protein 0.0139 0.0626 0.0626
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0139 0.0626 0.0626
Echinococcus multilocularis cpg binding protein 0.0033 0.0091 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.1298 0.6461 0.6461
Schistosoma mansoni lamin 0.0029 0.0073 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0273 0.0273
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0015 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0698 0.3443 0.3443
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0107 0.0464 0.0464
Trypanosoma brucei hypothetical protein, conserved 0.0015 0.0001 0.0001
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0226 0.1065 0.1065
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0015 0.0001 0.0001
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0709 0.3496 0.3496
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.2 1 1
Leishmania major cathepsin L-like protease 0.0069 0.0273 0.0273
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0107 0.0464 0.0464
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0017
Loa Loa (eye worm) phosphatidylinositol 3 0.2 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0022 0.0037 0.0037
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0017 0.0017
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0017 0.0279
Mycobacterium ulcerans hypothetical protein 0.0015 0.0001 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0017
Schistosoma mansoni cpg binding protein 0.0033 0.0091 0.0091
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0258 0.1225 0.1225
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0107 0.0464 0.0464
Echinococcus granulosus cpg binding protein 0.0033 0.0091 0.0091
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0139 0.0626 0.0626
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.2 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0273 0.0273
Schistosoma mansoni 60S ribosomal protein L21 0.0017 0.0014 0.0014
Onchocerca volvulus 0.0018 0.0017 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.12 0.5971 0.5971
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0748 0.3691 0.3691
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0037 0.0037
Loa Loa (eye worm) phosphatidylinositol 3 0.0139 0.0626 0.0626
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0017 0.0279
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0017 0.0242
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0001 0.0001
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.2 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0198 0.0921 0.0921
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0198 0.0921 0.0921
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0158 0.0724 0.0723
Trichomonas vaginalis PIKK family atypical protein kinase 0.1599 0.7981 0.7981
Trichomonas vaginalis PIKK family atypical protein kinase 0.0698 0.3443 0.3443
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0158 0.0724 0.0724
Loa Loa (eye worm) hypothetical protein 0.0096 0.0409 0.0409
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0748 0.3691 0.3691
Loa Loa (eye worm) hypothetical protein 0.0257 0.1222 0.1222
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0107 0.0464 0.0464
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0748 0.3691 0.3691
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0273 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0017
Giardia lamblia Hypothetical protein 0.0139 0.0626 0.0626
Entamoeba histolytica hypothetical protein 0.0396 0.1922 0.1922
Trichomonas vaginalis PIKK family atypical protein kinase 0.1599 0.7981 0.7981
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0139 0.0626 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0396 0.1922 0.1922
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0139 0.0626 0.0626
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0273 0.0273
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0107 0.0464 0.0464
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0286 0.1368 0.1367
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0178 0.0824 0.0824
Loa Loa (eye worm) phosphatidylinositol 3 0.0139 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0139 0.0626 0.0626
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0273 0.0273
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0032 0.0088 0.0088
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0092 0.039 0.039
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0158 0.0724 0.0724
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0037 0.0037
Trypanosoma cruzi target of rapamycin kinase 3 0.1601 0.7989 0.7989
Brugia malayi Cyclic-nucleotide gated cation channel 0.0022 0.0037 0.0037
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0015 0.0001 0.0009
Leishmania major hypothetical protein, unknown function 0.0139 0.0626 0.0626
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0396 0.1922 0.1922
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0495 0.2418 0.2418
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0083 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0441 0.2147 0.2147
Entamoeba histolytica hypothetical protein 0.0139 0.0626 0.0626
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0302 0.1447 0.1447
Entamoeba histolytica hypothetical protein 0.0139 0.0626 0.0626
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0107 0.0464 1
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0017 0.0017
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0037 0.0037
Schistosoma mansoni fk506 binding protein 0.0015 0.0001 0.0001
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0017 0.0017
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.2 1 1
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0015 0.0001 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.0626 0.0626
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0001 0.0001
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0017 0.0017
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0396 0.1922 0.1922
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0139 0.0626 0.8653
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.1342 0.6685 0.6685
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0139 0.0626 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.1498 0.7472 0.7472
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0273 0.0273
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0139 0.0626 0.0626
Toxoplasma gondii target of rapamycin (TOR), putative 0.1498 0.7472 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1498 0.7472 0.7472
Onchocerca volvulus 0.0139 0.0626 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0017 0.0017
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0015 0.0001 0.0001
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0022 0.0037 0.0037
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0158 0.0724 0.0724
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0158 0.0724 0.0724
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0175 0.0175
Plasmodium vivax hypothetical protein, conserved 0.0139 0.0626 0.8653
Trichomonas vaginalis fk506 binding protein, putative 0.0015 0.0001 0.0001
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0158 0.0724 0.0724
Trichomonas vaginalis PIKK family atypical protein kinase 0.1498 0.7472 0.7472
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0015 0.0001 0.0001
Echinococcus multilocularis 0.0015 0.0001 0.0001
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0107 0.0464 0.0464
Echinococcus granulosus lamin 0.0029 0.0073 0.0073
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0015 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0302 0.1447 0.1447
Schistosoma mansoni immunophilin 0.0092 0.039 0.039
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0139 0.0626 0.0626
Leishmania major phosphatidylinositol kinase, putative 0.0139 0.0626 0.0626
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0107 0.0464 0.0464
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0302 0.1447 0.1447
Brugia malayi Cathepsin L-like precursor 0.0018 0.0017 0.0017
Loa Loa (eye worm) FKBP5 protein 0.0107 0.0464 0.0464
Echinococcus multilocularis cysteine protease 0.0018 0.0017 0.0017
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0495 0.2418 0.2418
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.2 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0258 0.1225 0.1225
Echinococcus granulosus FK506 binding protein 2 0.0015 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0017 0.0017
Plasmodium vivax vivapain-2 0.0018 0.0017 0.0242
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0107 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0037
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0017 0.0242
Echinococcus multilocularis dnaJ subfamily B 0.0441 0.2148 0.2148
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0396 0.1922 0.1922
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0017 0.0017
Trichomonas vaginalis fk506-binding protein, putative 0.0015 0.0001 0.0001
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.0088 0.0088
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0158 0.0724 0.0724
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0107 0.0464 0.0464
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0139 0.0626 0.0626
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0107 0.0464 0.6415
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0107 0.0464 0.0464
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.0015 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0273 0.0273
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0015 0.0001 0.0001
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0015 0.0001 0.0001
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0037 0.0037
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0015 0.0001 0.0008
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0407 0.1975 0.1975
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0017 0.0017
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0015 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0257 0.1222 0.1222
Echinococcus granulosus cathepsin l1 0.0018 0.0017 0.0017
Schistosoma mansoni immunophilin 0.0107 0.0464 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0257 0.1222 0.1222
Schistosoma mansoni voltage-gated potassium channel 0.0121 0.0534 0.0534
Schistosoma mansoni fkbp-rapamycin associated protein 0.0396 0.1922 0.1922
Trichomonas vaginalis PIKK family atypical protein kinase 0.1498 0.7472 0.7472
Echinococcus multilocularis geminin 0.0183 0.0847 0.0847
Echinococcus multilocularis musashi 0.0029 0.0073 0.0073
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0325 0.1566 0.1565
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0037 0.0037
Echinococcus granulosus lamin dm0 0.0029 0.0073 0.0073
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0396 0.1922 0.1922
Loa Loa (eye worm) phosphatidylinositol 3 0.0709 0.3496 0.3496
Schistosoma mansoni cpg binding protein 0.0031 0.0083 0.0083
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0015 0.0001 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0088 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.1097 0.5453 0.5453
Mycobacterium tuberculosis Conserved hypothetical protein 0.0139 0.0626 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.0139 0.0626 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.1099 0.5461 0.5461
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0139 0.0626 0.0838
Echinococcus granulosus voltage gated potassium channel 0.0032 0.0088 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.1599 0.7981 0.7981
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0139 0.0626 0.0838

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.801 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.61 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.421 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.397 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.143 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.083 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.933 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.915 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.884 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.838 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.826 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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