Detailed information for compound 1627955

Basic information

Technical information
  • TDR Targets ID: 1627955
  • Name: 2-[(Z)-2,3-dichloro-3-morpholin-4-yl-1-nitrop rop-2-enylidene]-1,3-dihydrobenzimidazole
  • MW: 357.192 | Formula: C14H14Cl2N4O3
  • H donors: 2 H acceptors: 2 LogP: 3.15 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)C(=c1[nH]c2c([nH]1)cccc2)/C(=C(\N1CCOCC1)/Cl)/Cl
  • InChi: 1S/C14H14Cl2N4O3/c15-11(13(16)19-5-7-23-8-6-19)12(20(21)22)14-17-9-3-1-2-4-10(9)18-14/h1-4,17-18H,5-8H2/b13-11+
  • InChiKey: CJCLURGDRRUBOM-ACCUITESSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(Z)-2,3-dichloro-3-morpholino-1-nitro-prop-2-enylidene]-1,3-dihydrobenzimidazole
  • 2-[(Z)-2,3-dichloro-3-morpholino-1-nitroprop-2-enylidene]-1,3-dihydrobenzimidazole
  • 2-[(Z)-2,3-dichloro-3-morpholin-4-yl-1-nitro-prop-2-enylidene]-1,3-dihydrobenzimidazole
  • NSC698383

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0069 0.0063
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.003 0.0172 0.1919
Echinococcus granulosus dna polymerase kappa 0.0015 0.0041 0.0084
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Toxoplasma gondii LsmAD domain-containing protein 0.002 0.0081 0.0719
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0306 0.0266
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0081 0.0919
Echinococcus granulosus serine:threonine protein kinase 3 0.024 0.1977 0.4289
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0174 0.1403 0.1397
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0228 0.0221
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Entamoeba histolytica PH domain containing protein kinase, putative 0.0031 0.0172 0.0564
Echinococcus granulosus Protein kinase C brain isozyme 0.0116 0.0907 0.1964
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0739 0.0701
Loa Loa (eye worm) trypsin family protein 0.0037 0.0228 0.0221
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0425 0.0385
Brugia malayi Trypsin family protein 0.0037 0.0228 0.0221
Schistosoma mansoni protein kinase C mu 0.0029 0.0162 0.0156
Leishmania major protein kinase, putative 0.0061 0.0433 0.5183
Brugia malayi hypothetical protein 0.0013 0.002 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0425 0.0418
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0069 0.0063
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0739 0.0701
Brugia malayi Variant SH3 domain containing protein 0.0029 0.0162 0.0156
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0425 0.5188
Echinococcus multilocularis Diacylglycerol kinase theta 0.0029 0.0162 0.0221
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0127
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0331 0.2756 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0041 0.0498
Schistosoma mansoni protein kinase 0.0018 0.0066 0.006
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0011 0.0006 0.0078
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0127
Trypanosoma cruzi cdc2-related kinase 3 0.0096 0.0739 0.9024
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0069 0.0063
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0069 0.0063
Brugia malayi diacylglycerol kinase 0.0029 0.0162 0.0156
Echinococcus granulosus serine/threonine protein kinase 0.0031 0.0172 0.037
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0018 0.0143
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.014 0.1117 0.1111
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0331 0.2756 0.2726
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0044 0.0287 0.0395
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0069 0.0063
Schistosoma mansoni serine/threonine kinase 0.0044 0.0287 0.0281
Loa Loa (eye worm) hypothetical protein 0.0145 0.1154 0.1149
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.003 0.0164 0.0157
Echinococcus multilocularis serine:threonine protein kinase 38 0.0044 0.0287 0.0395
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0331 0.2756 0.2726
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0818 0.0781
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0069 0.0063
Brugia malayi WH1 domain containing protein 0.0016 0.005 0.0044
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0331 0.2756 0.2751
Echinococcus multilocularis protein kinase c epsilon type 0.0075 0.0551 0.076
Echinococcus granulosus twitchin 0.0035 0.0214 0.0461
Entamoeba histolytica diacylglycerol kinase, putative 0.0029 0.0162 0.0526
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0228 0.0221
Brugia malayi Protein kinase domain containing protein 0.016 0.1289 0.1283
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0287 0.0281
Giardia lamblia Kinase, NEK 0.0115 0.0895 0.3145
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0028 0.0154 0.1817
Leishmania major hypothetical protein, conserved 0.0043 0.0278 0.3242
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0069 0.0093
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0228 0.0221
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0069 0.0146
Loa Loa (eye worm) hypothetical protein 0.0037 0.0228 0.0221
Leishmania major hypothetical protein, conserved 0.002 0.0081 0.0787
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.085 0.7225 1
Echinococcus granulosus serine:threonine kinase SAD 1 0.003 0.0172 0.0368
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0425 0.5079
Loa Loa (eye worm) glutaminase 0.1173 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0162 0.0156
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0041 0.0423
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0739 0.0733
Loa Loa (eye worm) hypothetical protein 0.0174 0.1407 0.1401
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0228 0.0221
Brugia malayi Trypsin family protein 0.0037 0.0228 0.0221
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0818 0.0781
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0069 0.0093
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0063
Echinococcus multilocularis serine:threonine kinase SAD 1 0.003 0.0172 0.0235
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0195 0.1589 0.2198
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0016 0.005 0.0044
Loa Loa (eye worm) raf kinase 0.0029 0.0162 0.0156
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0011 0.0006 0.0009
Schistosoma mansoni serine/threonine-protein kinase 0.0031 0.0172 0.0166
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0016 0.005 0.0044
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0174 0.1403 0.1397
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0096 0.0739 0.901
Onchocerca volvulus 0.0159 0.128 0.4631
Brugia malayi hypothetical protein 0.0026 0.0133 0.0127
Loa Loa (eye worm) hypothetical protein 0.0085 0.0642 0.0636
Brugia malayi CXXC zinc finger family protein 0.003 0.0168 0.0162
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0081 0.0919
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0127
Onchocerca volvulus 0.0085 0.0642 0.231
Brugia malayi RhoGAP domain containing protein 0.0029 0.0162 0.0156
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0034 0.02 0.1457
Loa Loa (eye worm) hypothetical protein 0.0037 0.0228 0.0221
Brugia malayi P21-Rho-binding domain containing protein 0.0016 0.005 0.0044
Trypanosoma cruzi Protein kinase B 0.0031 0.0172 0.2045
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0041 0.0265 0.0364
Entamoeba histolytica diacylglycerol kinase, putative 0.0029 0.0162 0.0526
Trypanosoma brucei cdc2-related kinase 3 0.0096 0.0739 0.9032
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0029 0.0162 0.0221
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0041 0.0034
Trichomonas vaginalis glutaminase, putative 0.1173 1 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0977 0.0971
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Entamoeba histolytica protein kinase, putative 0.0046 0.0309 0.1063
Brugia malayi nuclear hormone receptor 0.0019 0.0069 0.0063
Mycobacterium ulcerans hypothetical protein 0.0037 0.0228 0.0188
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Schistosoma mansoni protein kinase 0.0018 0.0066 0.006
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0398 0.0359
Loa Loa (eye worm) hypothetical protein 0.0032 0.018 0.0174
Brugia malayi cell division control protein 2 homolog 0.0096 0.0739 0.0733
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0069 0.0063
Schistosoma mansoni hypothetical protein 0.0429 0.3599 0.3595
Echinococcus granulosus Rac GTPase activating protein 1 0.0029 0.0162 0.0347
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0041 0.0498
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0028 0.0154 0.021
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0398 0.1389
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0069 0.0063
Entamoeba histolytica protein kinase, putative 0.0057 0.0398 0.1389
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0739 0.0701
Trichomonas vaginalis AGC family protein kinase 0.0068 0.049 0.0452
Echinococcus granulosus serine:threonine protein kinase PAK 1 0.0023 0.0104 0.0221
Brugia malayi Protein kinase domain containing protein 0.0068 0.049 0.0484
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0287 0.0281
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0069 0.0063
Trichomonas vaginalis STE family protein kinase 0.0046 0.0304 0.0265
Echinococcus granulosus histone acetyltransferase KAT2B 0.0112 0.0869 0.1881
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0069 0.0146
Echinococcus granulosus protein kinase c epsilon type 0.0075 0.0551 0.1192
Brugia malayi C1-like domain containing protein 0.0121 0.0954 0.0948
Trypanosoma brucei protein kinase, putative 0.0013 0.0018 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0041 0.0498
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0818 0.0781
Onchocerca volvulus 0.0037 0.0228 0.0805
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0041 0.0423
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0043 0.0278 0.0238
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0069 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0753 0.0748
Echinococcus multilocularis Immunoglobulin 0.0026 0.0133 0.0182
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0331 0.2756 0.2726
Schistosoma mansoni protein kinase C mu 0.0121 0.0954 0.0948
Brugia malayi Temporarily assigned gene name protein 59 0.0135 0.1067 0.1061
Brugia malayi Hr1 repeat family protein 0.0044 0.0287 0.0281
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0228 0.0221
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0131 0.1036 0.1031
Giardia lamblia Kinase, STE STE20 0.0046 0.0304 0.0971
Echinococcus granulosus dnaJ subfamily B 0.0429 0.3599 0.781
Loa Loa (eye worm) hypothetical protein 0.0037 0.0228 0.0221
Trypanosoma cruzi cdc2-related kinase 1 0.0096 0.0739 0.9024
Onchocerca volvulus 0.0117 0.0913 0.3296
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0041 0.0498
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Brugia malayi protein kinase C II. 0.0075 0.0551 0.0545
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0388 0.0349
Trypanosoma brucei polo-like protein kinase 0.0106 0.0818 1
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0044 0.0287 0.0619
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0106 0.0818 0.0813
Brugia malayi Trypsin family protein 0.0037 0.0228 0.0221
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0228 0.0221
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0459 0.0453
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.1474 0.1469
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0121 0.0954 0.0948
Schistosoma mansoni serine/threonine protein kinase 0.0131 0.1036 0.1031
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0069 0.0063
Brugia malayi Protein kinase c protein 2 0.0079 0.0589 0.0583
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0172 0.0165
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0018 0.0066 0.0139
Trichomonas vaginalis AGC family protein kinase 0.0115 0.0895 0.0857
Loa Loa (eye worm) hypothetical protein 0.0117 0.0913 0.0907
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0331 0.2756 0.2726
Echinococcus multilocularis microtubule associated protein 2 0.0546 0.4608 0.6377
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.1589 0.1584
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0818 0.0781
Echinococcus multilocularis raf serine:threonine protein kinase 0.0035 0.0211 0.0289
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0096 0.0739 0.0733
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0037 0.0228 0.049
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0106 0.0818 0.113
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0041 0.0498
Loa Loa (eye worm) hypothetical protein 0.002 0.0081 0.0075
Schistosoma mansoni ste20-related kinase 0.0187 0.1514 0.1508
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0398 0.1317
Echinococcus multilocularis serine:threonine protein kinase N2 0.0044 0.0287 0.0395
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0424 0.4635
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0044 0.0287 0.0395
Schistosoma mansoni rac gtpase activating protein 0.0029 0.0162 0.0156
Entamoeba histolytica protein kinase, putative 0.0068 0.049 0.1726
Giardia lamblia Kinase, PLK 0.0106 0.0818 0.2864
Loa Loa (eye worm) hypothetical protein 0.0071 0.0518 0.0512
Giardia lamblia Kinase, AGC PKA 0.0028 0.0154 0.0417
Echinococcus granulosus protein kinase C gamma type 0.0087 0.0654 0.1416
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0057 0.0398 0.4827
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0228 0.0221
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Echinococcus multilocularis cyclin dependent kinase 5 0.0096 0.0739 0.1021
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0043 0.0278 0.0238
Echinococcus granulosus rho-associated protein kinase 1 0.0159 0.128 0.2774
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0041 0.0498
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0425 0.1414
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0398 0.0392
Brugia malayi Protein kinase domain containing protein 0.0182 0.1474 0.1469
Loa Loa (eye worm) hypothetical protein 0.014 0.1117 0.1111
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0011 0.0006 0.0009
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0046 0.0304 0.0656
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0057 0.0398 0.0392
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0029 0.0162 0.0156
Brugia malayi p70 ribosomal S6 kinase beta 0.0065 0.0472 0.0466
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0172 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0041 0.0498
Echinococcus granulosus cyclin dependent kinase 1 0.0096 0.0739 0.16
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0425 0.0385
Echinococcus multilocularis Glutaredoxin protein 5 0.0021 0.0094 0.0128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0069 0.0146
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0288 0.2388 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0069 0.0063
Echinococcus granulosus RNA directed DNA polymerase 0.0041 0.0265 0.0571
Echinococcus multilocularis Rac GTPase activating protein 1 0.0029 0.0162 0.0221
Echinococcus granulosus microtubule associated protein 2 0.0546 0.4608 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0425 0.0585
Schistosoma mansoni protein kinase 0.0046 0.0304 0.0298
Echinococcus granulosus activin receptor type 0.0013 0.0018 0.0034
Entamoeba histolytica protein kinase, putative 0.0025 0.0128 0.0403
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0175 0.1413 0.3063
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0228 0.0221
Entamoeba histolytica protein kinase, putative 0.0023 0.011 0.0335
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0069 0.0063
Loa Loa (eye worm) hypothetical protein 0.0032 0.0182 0.0176
Mycobacterium ulcerans glutaminase 0.1173 1 1
Echinococcus granulosus Glutaredoxin protein 5 0.0021 0.0094 0.02
Loa Loa (eye worm) hypothetical protein 0.0029 0.0162 0.0156
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0131 0.1036 0.2245
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0016 0.005 0.0104
Entamoeba histolytica PH domain containing protein kinase, putative 0.0031 0.0172 0.0564
Trichomonas vaginalis AGC family protein kinase 0.0068 0.049 0.0452
Entamoeba histolytica cell division protein kinase 2, putative 0.0096 0.0739 0.2634
Echinococcus granulosus raf serine:threonine protein kinase 0.0035 0.0211 0.0453
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0057 0.0398 0.086
Brugia malayi protein kinase C3,putative 0.0036 0.0222 0.0215
Echinococcus multilocularis RNA directed DNA polymerase 0.0041 0.0265 0.0364
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0388 0.0349
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.0818 1
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0287 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0069 0.0063
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0331 0.2756 0.2726
Schistosoma mansoni nephrin 0.0029 0.0155 0.0148
Schistosoma mansoni unc-13 (munc13) 0.0031 0.0173 0.0167
Echinococcus multilocularis serine:threonine protein kinase 3 0.024 0.1977 0.2735
Echinococcus granulosus nervana 2 0.0021 0.0094 0.02
Loa Loa (eye worm) TK/KIN16 protein kinase 0.018 0.1455 0.1449
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0037 0.0227 0.0187
Schistosoma mansoni diacylglycerol kinase theta 0.0029 0.0162 0.0156
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0069 0.0063
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0425 0.0917
Loa Loa (eye worm) hypothetical protein 0.0029 0.0161 0.0154
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0098 0.0753 0.104
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.0907 0.0901
Plasmodium falciparum NIMA related kinase 1 0.0115 0.0895 1
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0818 0.0781
Onchocerca volvulus Tyrosine kinase homolog 0.0153 0.1225 0.4432
Echinococcus granulosus cpg binding protein 0.0032 0.0183 0.0393
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0069 0.0229
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0028 0.0154 0.0897
Brugia malayi ecdysteroid receptor 0.0019 0.0069 0.0063
Loa Loa (eye worm) hypothetical protein 0.0037 0.0228 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0041 0.0498
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0034 0.02 0.0159
Schistosoma mansoni coup transcription factor 0.0019 0.0069 0.0063
Echinococcus granulosus serine threonine protein kinase nrc 0.0028 0.0154 0.033
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0425 0.515
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0026 0.0133 0.0182
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0044 0.0287 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0069 0.0063
Trichomonas vaginalis STE family protein kinase 0.0061 0.0433 0.0394
Entamoeba histolytica hypothetical protein 0.0016 0.005 0.0117
Brugia malayi Immunoglobulin I-set domain containing protein 0.0026 0.0133 0.0127
Brugia malayi hypothetical protein 0.0024 0.0112 0.0106
Brugia malayi serine/threonine-protein kinase PAK 7 0.0023 0.011 0.0103
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0029 0.0161 0.0344
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0099 0.0093
Loa Loa (eye worm) AGC/PKN protein kinase 0.0044 0.0287 0.0281
Trichomonas vaginalis STE family protein kinase 0.0046 0.0304 0.0265
Echinococcus granulosus tyrosine protein kinase Lyn 0.0013 0.0018 0.0034
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0034 0.02 0.2071
Schistosoma mansoni hypothetical protein 0.0016 0.005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0037 0.0228 0.0221
Loa Loa (eye worm) hypothetical protein 0.0037 0.0228 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0069 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0034 0.02 0.0159
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0211 0.0205
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0175 0.1413 0.1953
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0046 0.0304 0.0656
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0331 0.2756 0.2726
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.003 0.0172 0.1113
Echinococcus multilocularis neuroglian 0.0029 0.0155 0.0211
Echinococcus multilocularis activin receptor type 0.0013 0.0018 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0309 0.0303
Toxoplasma gondii diacylglycerol kinase, putative 0.0029 0.0162 0.1641
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0331 0.2756 0.2726
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0818 0.0813
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0037 0.0228 0.0221
Schistosoma mansoni hypothetical protein 0.0037 0.0228 0.0221
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0044 0.0287 0.0619
Brugia malayi steroid hormone receptor 0.0019 0.0069 0.0063
Onchocerca volvulus 0.0037 0.0228 0.0805
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0011 0.0006 0.0006
Schistosoma mansoni tyrosine kinase 0.0022 0.0099 0.0093
Loa Loa (eye worm) hypothetical protein 0.0114 0.0894 0.0888
Entamoeba histolytica serine/threonine protein kinase, putative 0.0106 0.0818 0.2924
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0069 0.0063
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0228 0.0221
Schistosoma mansoni serine/threonine protein kinase 0.0174 0.1403 0.1397
Schistosoma mansoni glutaminase 0.1173 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0069 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.1084 0.1048
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Schistosoma mansoni diacylglycerol kinase theta 0.0029 0.0162 0.0156
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0046 0.0309 0.0666
Entamoeba histolytica p21-activated kinase 0.0048 0.0323 0.1113
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0425 0.515
Loa Loa (eye worm) AGC/AKT protein kinase 0.0068 0.049 0.0484
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0228 0.0221
Giardia lamblia Kinase, CMGC GSK 0.0057 0.0398 0.1317
Echinococcus multilocularis dnaJ subfamily B 0.0429 0.3599 0.498
Schistosoma mansoni serine/threonine-protein kinase 0.0031 0.0172 0.0166
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0041 0.0034
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0287 0.0247
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0026 0.0133 0.0127
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0031 0.0172 0.2045
Schistosoma mansoni hypothetical protein 0.0016 0.005 0.0044
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0016 0.005 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0164 0.0157
Brugia malayi Protein kinase domain containing protein 0.0018 0.0066 0.006
Echinococcus granulosus myotubularin protein 13 0.0032 0.018 0.0387
Loa Loa (eye worm) hypothetical protein 0.0041 0.0265 0.0259
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0172 0.0165
Brugia malayi Immunoglobulin I-set domain containing protein 0.018 0.1455 0.1449
Giardia lamblia Kinase, CMGC CDK 0.0096 0.0739 0.2572
Brugia malayi Fibronectin type III domain containing protein 0.0026 0.0133 0.0127
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0046 0.0304 0.0656
Echinococcus multilocularis cyclin dependent kinase 1 0.0096 0.0739 0.1021
Brugia malayi Protein kinase domain containing protein 0.0174 0.1403 0.1397
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0096 0.0739 0.901
Onchocerca volvulus 0.0019 0.0069 0.0229
Schistosoma mansoni cpg binding protein 0.003 0.0168 0.0162
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0018 0.0066 0.0089
Onchocerca volvulus 0.0145 0.1154 0.4176
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0228 0.0221
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0425 0.4637
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0046 0.0309 0.0425
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0069 0.0063
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0046 0.0304 0.0418
Echinococcus multilocularis dna polymerase eta 0.0015 0.0041 0.0054
Plasmodium falciparum glycogen synthase kinase 3 0.0057 0.0398 0.4339
Echinococcus multilocularis cyclin dependent kinase 0.0096 0.0739 0.1021
Brugia malayi diacylglycerol kinase 0.0029 0.0162 0.0156
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0063
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0041 0.0423
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0131 0.1036 0.1031
Onchocerca volvulus 0.0145 0.1154 0.4176
Brugia malayi putative serine/threonine kinase SADA gamma 0.003 0.0172 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0739 0.0733
Trypanosoma brucei PAB1-binding protein , putative 0.002 0.0081 0.099
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0164 0.0157
Echinococcus multilocularis dna polymerase kappa 0.0015 0.0041 0.0054
Schistosoma mansoni protein kinase 0.0046 0.0304 0.0298
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0057 0.0398 0.0549
Onchocerca volvulus 0.0331 0.2756 1
Brugia malayi hypothetical protein 0.002 0.0081 0.0075
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0028 0.0154 0.033
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0425 0.0385
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0069 0.0063
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0106 0.0818 0.1772
Trypanosoma brucei protein kinase, putative 0.006 0.0425 0.5188
Trypanosoma cruzi p21-activated kinase 3, putative 0.003 0.0164 0.1936
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0069 0.0146
Entamoeba histolytica cell division protein kinase 2, putative 0.0096 0.0739 0.2634
Schistosoma mansoni kinase 0.0057 0.0399 0.0393
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0016 0.005 0.0104
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0331 0.2756 0.2751
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0069 0.0093
Loa Loa (eye worm) hypothetical protein 0.0189 0.1532 0.1527
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0228 0.0221
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0043 0.0278 0.3391
Schistosoma mansoni protein kinase 0.0023 0.011 0.0103
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0069 0.0146
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0041 0.0498
Trichomonas vaginalis AGC family protein kinase 0.0068 0.049 0.0452
Trypanosoma brucei cdc2-related kinase 1 0.0096 0.0739 0.9032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0228 0.0221
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0046 0.0309 0.0666
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0069 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0278 0.3339
Echinococcus granulosus histone acetyltransferase KAT2B 0.0034 0.02 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0069 0.0063
Entamoeba histolytica protein kinase, putative 0.0044 0.0287 0.0983
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0425 0.0585
Echinococcus granulosus Mastin 0.0037 0.0228 0.049
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0036 0.0222 0.0215
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0041 0.0423
Echinococcus granulosus N chimaerin 0.0029 0.0162 0.0347
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0031 0.0173 0.0371
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0026 0.0133 0.0127
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0228 0.0221
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0096 0.0739 0.16
Echinococcus multilocularis glycoprotein Antigen 5 0.0037 0.0228 0.0312
Brugia malayi Protein kinase domain containing protein 0.0481 0.4046 0.4043
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0069 0.0063
Schistosoma mansoni protein kinase 0.0013 0.0018 0.0012
Toxoplasma gondii histone kinase SNF1, putative 0.003 0.0172 0.1752
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0046 0.0309 0.0425
Trypanosoma cruzi cdc2-related kinase 1 0.0096 0.0739 0.9024
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0069 0.0063
Echinococcus granulosus Vam6:Vps39 protein 0.0011 0.0006 0.0009
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.0094 0.0128
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0041 0.0083
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0063
Onchocerca volvulus 0.003 0.0168 0.0589
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0115 0.0896 0.089
Echinococcus multilocularis myotubularin protein 13 0.0032 0.018 0.0247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0069 0.0063
Schistosoma mansoni cpg binding protein 0.0032 0.0183 0.0177
Echinococcus multilocularis cpg binding protein 0.0032 0.0183 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0245 0.0205
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0228 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0069 0.0063
Schistosoma mansoni hypothetical protein 0.0016 0.005 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0069 0.0063
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0069 0.0093
Loa Loa (eye worm) hypothetical protein 0.0085 0.0642 0.0636
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Echinococcus multilocularis cyclin dependent kinase 1 0.0096 0.0739 0.1021
Loa Loa (eye worm) AGC/NDR protein kinase 0.0044 0.0287 0.0281
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0023 0.011 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0041 0.0498
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.024 0.1977 0.1972
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0061 0.0433 0.5289
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0115 0.0895 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0173 0.0167
Entamoeba histolytica hypothetical protein 0.0016 0.005 0.0117
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0041 0.0034
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0098 0.0753 0.1631
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Echinococcus multilocularis transmembrane protease serine 3 0.0037 0.0228 0.0312
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0065 0.0472 0.0466
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0063
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0069 0.0146
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0228 0.0312
Onchocerca volvulus 0.0037 0.0228 0.0805
Echinococcus granulosus protein kinase c iota type 0.0073 0.054 0.1167
Echinococcus multilocularis nervana 2 0.0021 0.0094 0.0128
Brugia malayi serine/threonine-protein kinase plk-2 0.0106 0.0818 0.0813
Entamoeba histolytica protein kinase, putative 0.0046 0.0309 0.1063
Schistosoma mansoni protein kinase C 0.0031 0.0173 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Brugia malayi STE20-like kinase MST 0.024 0.1977 0.1972
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.003 0.0172 0.1919
Schistosoma mansoni DNA polymerase eta 0.0015 0.0041 0.0034
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0092 0.0701 0.0695
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0013 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.009 0.068 0.0674
Brugia malayi Protein kinase domain containing protein 0.0044 0.0287 0.0281
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0069 0.0093
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0063
Brugia malayi Trypsin family protein 0.0037 0.0228 0.0221
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0425 0.0385
Schistosoma mansoni unc-13 (munc13) 0.0031 0.0173 0.0167
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0057 0.0398 0.4752
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0228 0.0221
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0034
Brugia malayi nuclear receptor NHR-88 0.0019 0.0069 0.0063
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0044 0.0287 0.0395
Echinococcus granulosus neuroglian 0.0029 0.0155 0.0331
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.003 0.0164 0.0157
Plasmodium falciparum protein kinase 5 0.0096 0.0739 0.8226
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0061 0.0433 0.5252
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0037 0.0228 0.0221
Echinococcus multilocularis protein kinase shaggy 0.0057 0.0398 0.0549
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.003 0.0164 0.1936
Trypanosoma brucei rac serine-threonine kinase, putative 0.0068 0.049 0.5993
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0069 0.0146
Trypanosoma brucei protein kinase, putative 0.0057 0.0398 0.4868
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0228 0.0221
Trypanosoma cruzi SNF1-related protein kinases, putative 0.003 0.0172 0.2035
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0029 0.0162 0.0156
Loa Loa (eye worm) hypothetical protein 0.0032 0.0182 0.0176
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0046 0.0304 0.0418
Entamoeba histolytica acetyltransferase, GNAT family 0.0031 0.0175 0.0575
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0753 0.0748
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0115 0.0896 0.1238
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0195 0.1589 0.3446
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0081 0.0719
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0425 0.5079
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0818 0.0781
Echinococcus granulosus PAK box P21 Rho binding 0.0016 0.005 0.0104
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0131 0.1036 0.1432
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0041 0.0054
Brugia malayi Protein kinase domain 0.0046 0.0304 0.0298
Loa Loa (eye worm) hypothetical protein 0.0029 0.0162 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0069 0.0063
Onchocerca volvulus Serine\/threonine kinase homolog 0.0106 0.0818 0.2953
Brugia malayi Pleckstrin Homology Domain 0.0032 0.018 0.0174
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0195 0.1589 0.1584
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0174 0.1403 0.5079
Plasmodium vivax glycogen synthase kinase 3, putative 0.0057 0.0398 0.39
Echinococcus multilocularis nervana 2 0.0021 0.0094 0.0128
Onchocerca volvulus 0.0037 0.0228 0.0805
Trypanosoma brucei SNF1-related protein kinases, putative 0.003 0.0172 0.2097
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0174 0.1403 0.3041
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0041 0.0034
Plasmodium falciparum histone acetyltransferase GCN5 0.0031 0.0175 0.1795
Echinococcus granulosus roundabout 2 0.0032 0.0182 0.0391
Brugia malayi Protein kinase domain containing protein 0.0044 0.0287 0.0281
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0121 0.0954 0.0948
Schistosoma mansoni hypothetical protein 0.0029 0.0162 0.0156
Echinococcus granulosus protein kinase shaggy 0.0057 0.0398 0.086
Echinococcus granulosus serine:threonine protein kinase N2 0.0044 0.0287 0.0619
Echinococcus multilocularis serine:threonine protein kinase N2 0.0044 0.0287 0.0395
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0041 0.0498
Schistosoma mansoni vav2 0.0032 0.018 0.0174
Schistosoma mansoni cpg binding protein 0.0032 0.0183 0.0177
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0018 0.0066 0.0089
Schistosoma mansoni atypical protein kinase C 0.0073 0.054 0.0534
Giardia lamblia Kinase, NEK 0.0115 0.0895 0.3145
Giardia lamblia Kinase, STE STE20 0.0061 0.0433 0.1444
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.003 0.0172 0.2035
Brugia malayi Ras association domain family 1 isoform A 0.0029 0.0162 0.0156
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0127
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0018 0.0066 0.006
Schistosoma mansoni vesicular amine transporter 0.003 0.0166 0.016
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0331 0.2756 1
Echinococcus granulosus protein kinase c eta type 0.0029 0.0162 0.0347
Echinococcus granulosus glycoprotein Antigen 5 0.0037 0.0228 0.049
Brugia malayi hypothetical protein 0.0037 0.0228 0.0221
Echinococcus multilocularis unc 13 (munc13) 0.0031 0.0173 0.0237
Entamoeba histolytica protein kinase, putative 0.0068 0.049 0.1726
Trichomonas vaginalis AGC family protein kinase 0.0068 0.049 0.0452
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0069 0.0093
Schistosoma mansoni protein kinase 0.0016 0.005 0.0044
Onchocerca volvulus 0.0037 0.0228 0.0805
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0069 0.0229
Onchocerca volvulus 0.0031 0.0173 0.0607
Giardia lamblia Kinase, CAMK CAMKL 0.003 0.0172 0.0482
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0398 0.0359
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0029 0.0162 0.0156
Brugia malayi RhoGEF domain containing protein 0.0029 0.0162 0.0156
Entamoeba histolytica protein kinase 2, putative 0.0028 0.0154 0.0497
Entamoeba histolytica protein kinase, putative 0.0025 0.0128 0.0403
Echinococcus multilocularis protein kinase c iota type 0.0073 0.054 0.0744
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0069 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0041 0.0498
Echinococcus multilocularis enteropeptidase 0.0037 0.0228 0.0312
Brugia malayi intracellular kinase 0.0057 0.0398 0.0392
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0057 0.0398 0.0392
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0425 0.0917
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0115 0.0895 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0029 0.0162 0.0156
Schistosoma mansoni cercarial elastase (S01 family) 0.0037 0.0228 0.0221
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0331 0.2756 1
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0551 0.0545
Trichomonas vaginalis AGC family protein kinase 0.0068 0.049 0.0452
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0168 0.0162
Giardia lamblia Kinase, CMGC CDK 0.0096 0.0739 0.2572
Loa Loa (eye worm) hypothetical protein 0.0145 0.1154 0.1149
Giardia lamblia Kinase, CAMK CAMKL 0.003 0.0172 0.0482
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0057 0.0398 0.4339
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0069 0.0063
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0238
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0069 0.0063
Entamoeba histolytica protein kinase, putative 0.0065 0.0472 0.1658
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0106 0.0818 1
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0044 0.0287 0.0619
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0069 0.0063
Brugia malayi RhoGAP domain containing protein 0.0029 0.0162 0.0156
Echinococcus granulosus transmembrane protease serine 3 0.0037 0.0228 0.049
Schistosoma mansoni cell adhesion molecule 0.0029 0.0161 0.0154
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0096 0.0739 0.0733
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0287 0.0281
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0029 0.0162 0.0347
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0182 0.1474 0.1469
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0018 0.0066 0.0139
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0127
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.0907 0.0901
Echinococcus granulosus enteropeptidase 0.0037 0.0228 0.049
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.003 0.0164 0.0157
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0046 0.0304 0.0418
Echinococcus multilocularis PAK box P21 Rho binding 0.0016 0.005 0.0066
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0069 0.0063
Giardia lamblia Histone acetyltransferase GCN5 0.0031 0.0175 0.0496
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0425 0.0418
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.0094 0.02
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0069 0.0093
Schistosoma mansoni protein kinase 0.0175 0.1413 0.1407
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0069 0.0093
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0425 0.515
Brugia malayi Protein kinase domain containing protein 0.0096 0.0739 0.0733
Plasmodium vivax protein kinase Crk2 0.0096 0.0739 0.8088
Echinococcus multilocularis Immunoglobulin 0.0026 0.0133 0.0182
Toxoplasma gondii AGC kinase 0.0065 0.0472 0.5178
Echinococcus multilocularis roundabout 2 0.0032 0.0182 0.0249
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0818 0.0781
Onchocerca volvulus 0.0057 0.0398 0.1426
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.005 0.0336 0.033
Loa Loa (eye worm) RasGEF domain-containing protein 0.0029 0.0162 0.0156
Brugia malayi probable protein kinase 0.0018 0.0066 0.006
Echinococcus granulosus cyclin dependent kinase 0.0096 0.0739 0.16
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0018 0.022
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0069 0.0063
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0061 0.0433 0.1515
Onchocerca volvulus 0.0114 0.0894 0.3229
Entamoeba histolytica protein kinase, putative 0.0046 0.0304 0.1046
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0096 0.0739 0.8226
Echinococcus granulosus Diacylglycerol kinase theta 0.0029 0.0162 0.0347
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0481 0.4046 0.4043
Loa Loa (eye worm) hypothetical protein 0.003 0.0172 0.0165
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0037 0.0228 0.0312
Onchocerca volvulus 0.0152 0.122 0.4414
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0069 0.0063
Entamoeba histolytica hypothetical protein 0.0029 0.0162 0.0526
Loa Loa (eye worm) hypothetical protein 0.0029 0.0162 0.0156
Trypanosoma cruzi cdc2-related kinase 3 0.0096 0.0739 0.9024
Entamoeba histolytica serine/threonine protein kinase, putative 0.003 0.0172 0.0561
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.003 0.0164 0.0123
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0172 0.0165
Echinococcus granulosus unc 13 munc13 0.0031 0.0173 0.0371
Echinococcus multilocularis Mastin 0.0037 0.0228 0.0312
Brugia malayi acetyltransferase, GNAT family protein 0.0115 0.0896 0.089
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0061 0.0433 0.5252
Echinococcus granulosus dna polymerase eta 0.0015 0.0041 0.0084
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.003 0.0172 0.2097
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0034 0.02 0.2071
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0069 0.0093
Echinococcus multilocularis rac serine:threonine kinase 0.0031 0.0172 0.0236
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0116 0.0907 0.1252
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0425 0.515
Schistosoma mansoni hypothetical protein 0.0037 0.0228 0.0221
Brugia malayi Trypsin-like protease protein 5 0.0037 0.0228 0.0221
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0029 0.0162 0.0156
Echinococcus multilocularis PAK box P21 Rho binding 0.0023 0.011 0.0149
Plasmodium falciparum serine/threonine protein kinase KIN 0.003 0.0172 0.1752
Echinococcus multilocularis protein kinase c eta type 0.0029 0.0162 0.0221
Echinococcus granulosus nervana 2 0.0021 0.0094 0.02
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.003 0.0172 0.0165
Trichomonas vaginalis STE family protein kinase 0.0115 0.0895 0.0857
Echinococcus granulosus defective proboscis extension response 0.0026 0.0133 0.0285
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.128 0.1274
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0069 0.0146
Trichomonas vaginalis STE family protein kinase 0.0046 0.0304 0.0265
Loa Loa (eye worm) glutaminase 2 0.1173 1 1
Echinococcus multilocularis myosin iiia 0.0061 0.0433 0.0596
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0229 0.1879 0.1874
Brugia malayi MAP kinase sur-1 0.006 0.0425 0.0418
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0044 0.0287 0.0281
Trichomonas vaginalis STE family protein kinase 0.0046 0.0304 0.0265
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0287 0.0281
Brugia malayi map kinase activated protein kinase protein 2 0.0195 0.1589 0.1584
Schistosoma mansoni protein kinase 0.0175 0.1413 0.1407
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0018 0.0143
Giardia lamblia Kinase, NEK 0.0115 0.0895 0.3145
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0278 0.3339
Loa Loa (eye worm) hypothetical protein 0.0029 0.0162 0.0156
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0063
Echinococcus granulosus cyclin dependent kinase 5 0.0096 0.0739 0.16
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0228 0.0221
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0174 0.1403 0.1397
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0041 0.0498
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0174 0.1403 0.1939
Trichomonas vaginalis AGC family protein kinase 0.0068 0.049 0.0452
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.0818 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0063
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0041 0.0423
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0015 0.0041 0.0284
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0041 0.0498
Loa Loa (eye worm) hypothetical protein 0.0029 0.0162 0.0156
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0081 0.0719
Leishmania major DNA polymerase kappa, putative 0.0015 0.0041 0.0284
Echinococcus multilocularis serine threonine protein kinase 0.0087 0.0654 0.0903
Echinococcus multilocularis rho associated protein kinase 0.0159 0.128 0.1769
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0172 0.0131
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0028 0.0154 0.1551
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0096 0.0739 0.0733
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0041 0.0084
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0069 0.0063
Leishmania major DNA polymerase eta, putative 0.0015 0.0041 0.0284
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0041 0.0034
Trichomonas vaginalis AGC family protein kinase 0.0068 0.049 0.0452
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0061 0.0433 0.1515
Loa Loa (eye worm) hypothetical protein 0.0145 0.1154 0.1149
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0287 0.0247
Echinococcus multilocularis N chimaerin 0.0029 0.0162 0.0221
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0075 0.0551 0.0545
Echinococcus granulosus NDR protein kinase 0.0044 0.0287 0.0619
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0069 0.0146
Loa Loa (eye worm) hypothetical protein 0.0019 0.0069 0.0063
Trypanosoma brucei unspecified product 0.0015 0.0041 0.0498
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0127
Entamoeba histolytica protein kinase domain containing protein 0.0057 0.0398 0.1389
Trichomonas vaginalis STE family protein kinase 0.0023 0.011 0.0069
Loa Loa (eye worm) acetyltransferase 0.0115 0.0896 0.089
Echinococcus granulosus Immunoglobulin 0.0026 0.0133 0.0285
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0031 0.0173 0.0237
Schistosoma mansoni microtubule-associated protein tau 0.0546 0.4608 0.4604
Brugia malayi P21-Rho-binding domain containing protein 0.0016 0.005 0.0044
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0037 0.0228 0.049
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0106
Onchocerca volvulus 0.0037 0.0228 0.0805

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.566 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.533 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.144 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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