Detailed information for compound 1638486

Basic information

Technical information
  • TDR Targets ID: 1638486
  • Name: (3Z,6Z)-3-[(5-tert-butyl-1H-imidazol-4-yl)met hylidene]-6-(thiophen-3-ylmethylidene)piperaz ine-2,5-dione
  • MW: 342.415 | Formula: C17H18N4O2S
  • H donors: 3 H acceptors: 3 LogP: 2.5 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1[nH]/c(=C\c2cscc2)/c(=O)[nH]/c/1=C\c1nc[nH]c1C(C)(C)C
  • InChi: 1S/C17H18N4O2S/c1-17(2,3)14-11(18-9-19-14)7-13-16(23)20-12(15(22)21-13)6-10-4-5-24-8-10/h4-9H,1-3H3,(H,18,19)(H,20,23)(H,21,22)/b12-6-,13-7-
  • InChiKey: ONRHILUUDOJCLZ-QXFGSWAMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3Z,6Z)-3-[(5-tert-butyl-1H-imidazol-4-yl)methylene]-6-(3-thienylmethylene)piperazine-2,5-dione
  • (3Z,6Z)-3-[(5-tert-butyl-1H-imidazol-4-yl)methylene]-6-(3-thienylmethylene)piperazine-2,5-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AGC/AKT protein kinase 0.0032 0.0043 0.0043
Entamoeba histolytica hypothetical protein 0.0269 0.0612 0.06
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0022 0.0021
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0269 0.0612 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0001 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0136 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0269 0.0612 0.0612
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0269 0.0612 1
Plasmodium vivax hypothetical protein 0.0269 0.0612 1
Onchocerca volvulus 0.0046 0.0076 0.0887
Trichomonas vaginalis PIKK family atypical protein kinase 0.2707 0.6479 0.6479
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0022
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0022 0.0017 0.0017
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1399 0.333 0.3321
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0005 0.0005
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0061 0.0113 0.0112
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0066 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.1399 0.333 0.333
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0269 0.0612 0.0612
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0022 0.0021
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0136 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0022 0.0022
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4171 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0061 0.0113 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.4171 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0039 0.0039
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0054 0.0053
Loa Loa (eye worm) FKBP5 protein 0.0061 0.0113 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0022 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0022 0.0021
Echinococcus granulosus serine/threonine protein kinase 0.0022 0.0018 0.0018
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0046 0.0045
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0018 0.0018
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0022 0.0021
Echinococcus granulosus GPCR family 2 0.0037 0.0054 0.0053
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0061 0.0113 0.1658
Brugia malayi steroid hormone receptor 0.0024 0.0022 0.0021
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1972 0.4711 0.4688
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0269 0.0612 0.06
Trichomonas vaginalis PIKK family atypical protein kinase 0.3317 0.7947 0.7947
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0022 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0136 1
Leishmania major peptidylprolyl isomerase-like protein 0.0061 0.0113 0.0047
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0269 0.0612 0.0612
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0269 0.0612 0.0612
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0269 0.0612 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0789 0.1863 0.1862
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0022 0.0021
Brugia malayi beta-lactamase family protein 0.0042 0.0066 0.0066
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0269 0.0612 0.06
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0269 0.0612 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0269 0.0612 0.06
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4171 1 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1399 0.333 0.333
Echinococcus multilocularis fk506 binding protein 0.0061 0.0113 0.0112
Entamoeba histolytica hypothetical protein 0.0789 0.1863 0.1852
Schistosoma mansoni immunophilin 0.0053 0.0092 0.0092
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0269 0.0612 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.2252 0.5383 0.5383
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0269 0.0612 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.1863 0.1862
Echinococcus multilocularis 0.0269 0.0612 0.0612
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0789 0.1863 0.1852
Trichomonas vaginalis PIKK family atypical protein kinase 0.3317 0.7947 0.7947
Mycobacterium leprae conserved hypothetical protein 0.0269 0.0612 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0061 0.0113 0.6686
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0269 0.0612 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0269 0.0612 0.06
Loa Loa (eye worm) phosphatidylinositol 3 0.0269 0.0612 0.0612
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0117 0.0245 0.0245
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0061 0.0113 0.1658
Brugia malayi Pre-SET motif family protein 0.0243 0.055 0.055
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0269 0.0612 0.0612
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0022 0.0021
Plasmodium vivax multidomain scavenger receptor, putative 0.0046 0.0076 0.1043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0269 0.0612 0.0612
Schistosoma mansoni immunophilin 0.0061 0.0113 0.0112
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0054 0.0053
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3321 0.7955 0.7946
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0066 0.0066
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0269 0.0612 0.0612
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0049 0.0048
Echinococcus granulosus RUN 0.0046 0.0076 0.0075
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0061 0.0113 0.0099
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0022 0.0021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0022 0.0021
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0136 0.1274
Loa Loa (eye worm) hypothetical protein 0.0269 0.0612 0.0612
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4171 1 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0046 0.0076 0.0075
Leishmania major hypothetical protein, conserved 0.0269 0.0612 0.055
Trichomonas vaginalis PIKK family atypical protein kinase 0.2492 0.5961 0.5961
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1399 0.333 0.333
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0054 0.0053
Entamoeba histolytica hypothetical protein 0.0269 0.0612 0.06
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0017 0.0017
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0022 0.0021
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0043 0.0042
Schistosoma mansoni hypothetical protein 0.0037 0.0054 0.0053
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0022 0.0021
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0269 0.0612 0.0612
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4171 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.1399 0.333 0.333
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0269 0.0612 0.0612
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.002 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.3317 0.7947 0.7947
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0061 0.0113 0.0112
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0269 0.0612 0.0612
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0136 0.0135
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1399 0.333 0.3302
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0269 0.0612 0.0777
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.003 0.0038 0.0038
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1399 0.333 0.3302
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0061 0.0113 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.3102 0.7428 0.7428
Loa Loa (eye worm) phosphatidylinositol 3 0.0269 0.0612 0.0612
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0061 0.0113 0.0099
Mycobacterium tuberculosis Conserved hypothetical protein 0.0269 0.0612 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3102 0.7428 0.7428
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0269 0.0612 0.0612
Giardia lamblia Phosphatidylinositol 4-kinase 0.0269 0.0612 0.06
Echinococcus granulosus serine threonine protein kinase nrc 0.002 0.0013 0.0013
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0066 0.0024
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0022
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0269 0.0612 0.0572
Schistosoma mansoni rab6-interacting 0.0046 0.0076 0.0075
Echinococcus multilocularis lamin 0.0032 0.0041 0.004
Trypanosoma cruzi Protein kinase B 0.0022 0.0018 0.0005
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0022 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.3102 0.7428 0.7428
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0269 0.0612 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0066 0.0066
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0269 0.0612 0.0612
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0061 0.0113 0.0099
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0017 0.0017
Loa Loa (eye worm) phosphatidylinositol kinase 0.0269 0.0612 0.0612
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0022 0.0022
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0061 0.0113 0.0099
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0269 0.0612 0.0612
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0269 0.0612 0.06
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0075 0.0145 0.0144
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0041 0.0041
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0043 0.0042
Schistosoma mansoni hypothetical protein 0.008 0.0157 0.0156
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4171 1 1
Brugia malayi Pre-SET motif family protein 0.0035 0.0049 0.0048
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0001 0.0001
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0948 0.2247 0.2246
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0879 0.208 0.2763
Trichomonas vaginalis fk506-binding protein, putative 0.0061 0.0113 0.0112
Loa Loa (eye worm) hypothetical protein 0.0042 0.0066 0.0066
Leishmania major phosphatidylinositol kinase, putative 0.0269 0.0612 0.055
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0022 0.0021
Schistosoma mansoni hypothetical protein 0.061 0.1432 0.1432
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0269 0.0612 0.0612
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0269 0.0612 0.0777
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0269 0.0612 0.0777
Echinococcus granulosus serine protein kinase ATM 0.0789 0.1863 0.1862
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0066 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0037 0.0054 0.0053
Brugia malayi Calcitonin receptor-like protein seb-1 0.0117 0.0245 0.0245
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4171 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0049 0.0048
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0043 0.0042
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0022 0.0022
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0269 0.0612 0.0572
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0022 0.0022
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0005 0.0005
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0018 0.0005
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.061 0.1432 0.1432
Loa Loa (eye worm) hypothetical protein 0.0032 0.0041 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.3102 0.7428 0.7428
Schistosoma mansoni hypothetical protein 0.0269 0.0612 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.2798 0.6696 0.6696
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0054 0.0054
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0202 0.0452 0.0452
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0022 0.0021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0789 0.1863 0.1862
Loa Loa (eye worm) hypothetical protein 0.0269 0.0612 0.0612
Brugia malayi hypothetical protein 0.0143 0.031 0.0309
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0269 0.0612 0.0612
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0022 0.0021
Echinococcus multilocularis lamin dm0 0.0032 0.0041 0.004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0136 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3102 0.7428 0.7428
Entamoeba histolytica protein kinase rad3, putative 0.0789 0.1863 0.1852
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0269 0.0612 0.0612
Onchocerca volvulus 0.0042 0.0066 0.0729
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0066 0.0066
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0269 0.0612 0.06
Loa Loa (eye worm) hypothetical protein 0.0042 0.0066 0.0066
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0789 0.1863 0.1828
Loa Loa (eye worm) hypothetical protein 0.0042 0.0066 0.0066
Loa Loa (eye worm) phosphatidylinositol 3 0.1399 0.333 0.333
Trichomonas vaginalis PIKK family atypical protein kinase 0.2249 0.5375 0.5375
Loa Loa (eye worm) hypothetical protein 0.0042 0.0066 0.0066
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0022 0.0021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0269 0.0612 0.0612
Echinococcus multilocularis rac serine:threonine kinase 0.0022 0.0018 0.0018
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0269 0.0612 0.0777
Schistosoma mansoni lipoxygenase 0.0202 0.0452 0.0452
Trichomonas vaginalis PIKK family atypical protein kinase 0.2252 0.5383 0.5383
Trichomonas vaginalis PIKK family atypical protein kinase 0.3317 0.7947 0.7947
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0269 0.0612 0.06
Onchocerca volvulus 0.0046 0.0076 0.0887
Echinococcus granulosus intermediate filament protein 0.0032 0.0041 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0049 0.0048
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0161 0.0161
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0269 0.0612 0.0612
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0022 0.0021
Schistosoma mansoni intermediate filament proteins 0.0032 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.085 0.201 0.201
Onchocerca volvulus 0.0035 0.0049 0.0445
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0022 0.0021
Brugia malayi FAT domain containing protein 0.061 0.1432 0.1432
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0066 0.0882
Plasmodium vivax hypothetical protein, conserved 0.0269 0.0612 1
Schistosoma mansoni hypothetical protein 0.0046 0.0076 0.0075
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0017 0.0017
Leishmania major fk506-binding protein 1-like protein 0.0061 0.0113 0.0047
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.007 0.0133 0.0133
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0269 0.0612 0.06
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0022 0.0021
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0061 0.0113 0.0112
Schistosoma mansoni polycystin 1-related 0.0046 0.0076 0.0075
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0161 0.0161
Schistosoma mansoni hypothetical protein 0.0042 0.0066 0.0066
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0022
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0049 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.1119 0.2657 0.2657
Schistosoma mansoni loxhd1 0.0046 0.0076 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.2467 0.5902 0.5901
Brugia malayi ecdysteroid receptor 0.0024 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0022
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0061 0.0113 0.0112
Loa Loa (eye worm) hypothetical protein 0.0143 0.031 0.031
Entamoeba histolytica hypothetical protein 0.0042 0.0066 0.0053
Loa Loa (eye worm) hypothetical protein 0.0065 0.0121 0.0121
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.002 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0879 0.208 0.2079
Giardia lamblia Hypothetical protein 0.0269 0.0612 0.06
Trichomonas vaginalis conserved hypothetical protein 0.052 0.1215 0.1215
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0269 0.0612 0.06
Loa Loa (eye worm) doublecortin family protein 0.0046 0.0076 0.0076
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0269 0.0612 0.0612
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0066 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0022 0.0021
Onchocerca volvulus 0.0032 0.0041 0.0312
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0022 0.0021
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0092 0.0092
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0789 0.1863 0.1862
Echinococcus granulosus nervana 2 0.002 0.0013 0.0012
Echinococcus multilocularis RUN 0.0046 0.0076 0.0075
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0054 0.0053
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0049 0.0048
Brugia malayi nuclear receptor NHR-88 0.0024 0.0022 0.0021
Brugia malayi Doublecortin family protein 0.0046 0.0076 0.0075
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0269 0.0612 0.06
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0043 0.0042
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0017 0.0017
Entamoeba histolytica protein kinase, putative 0.003 0.0038 0.0025
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0269 0.0612 0.06
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4171 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1399 0.333 0.3321
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0269 0.0612 0.06
Brugia malayi p70 ribosomal S6 kinase beta 0.003 0.0038 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.3561 0.8533 0.8533
Echinococcus multilocularis nervana 2 0.002 0.0013 0.0012
Schistosoma mansoni hypothetical protein 0.0037 0.0054 0.0053
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0269 0.0612 0.06
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0117 0.0245 0.0245
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0269 0.0612 0.0612
Entamoeba histolytica hypothetical protein 0.0269 0.0612 0.06
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0022 0.0021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0269 0.0612 0.0612
Loa Loa (eye worm) phosphatidylinositol 3 0.0269 0.0612 0.0612
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0269 0.0612 0.06
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0066 0.0066
Brugia malayi Protein kinase domain containing protein 0.0032 0.0043 0.0042
Toxoplasma gondii FATC domain-containing protein 0.0789 0.1863 0.2469
Echinococcus granulosus Polycystic kidney disease protein 0.0046 0.0076 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.2252 0.5383 0.5383
Toxoplasma gondii target of rapamycin (TOR), putative 0.3102 0.7428 1
Trichomonas vaginalis set domain proteins, putative 0.0277 0.0631 0.0631
Brugia malayi nuclear hormone receptor 0.0024 0.0022 0.0021
Toxoplasma gondii ABC1 family protein 0.0042 0.0066 0.0038
Brugia malayi beta-lactamase 0.0042 0.0066 0.0066
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0049 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.1863 0.1862
Trichomonas vaginalis PIKK family atypical protein kinase 0.3317 0.7947 0.7947
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0269 0.0612 0.0612
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0269 0.0612 0.0612
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0269 0.0612 0.0612
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0018 0.0005
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0022
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0269 0.0612 0.0612
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0022 0.0021
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0061 0.0113 0.0112
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0269 0.0612 0.0612
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0022 0.0021
Schistosoma mansoni immunophilin 0.0061 0.0113 0.0112
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0269 0.0612 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0075 0.0145 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.1863 0.1862
Trichomonas vaginalis PIKK family atypical protein kinase 0.2252 0.5383 0.5383
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0269 0.0612 0.0612
Brugia malayi beta-lactamase family protein 0.0042 0.0066 0.0066
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0136 0.007
Echinococcus multilocularis lipoxygenase domain containing protein 0.0046 0.0076 0.0075
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0269 0.0612 0.06
Trichomonas vaginalis PIKK family atypical protein kinase 0.3102 0.7428 0.7428
Trichomonas vaginalis PIKK family atypical protein kinase 0.4171 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0269 0.0612 0.0612
Loa Loa (eye worm) hypothetical protein 0.0117 0.0245 0.0245
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0269 0.0612 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.2467 0.5902 0.5901
Trichomonas vaginalis PIKK family atypical protein kinase 0.2249 0.5375 0.5375
Leishmania major phosphatidylinositol kinase related protein, putative 0.0269 0.0612 0.055
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0269 0.0612 0.0612
Onchocerca volvulus 0.0277 0.0631 1
Brugia malayi latrophilin 2 splice variant baaae 0.008 0.0157 0.0156
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.061 0.1432 0.1432
Trichomonas vaginalis PIKK family atypical protein kinase 0.2492 0.5961 0.5961
Schistosoma mansoni lamin 0.0032 0.0041 0.004
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0269 0.0612 0.0612
Loa Loa (eye worm) hypothetical protein 0.061 0.1432 0.1432
Echinococcus granulosus lamin dm0 0.0032 0.0041 0.004
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0066 0.0066
Brugia malayi hypothetical protein 0.0046 0.0076 0.0075
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0269 0.0612 0.0612
Plasmodium vivax SET domain protein, putative 0.0035 0.0049 0.0593
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0022 0.0021
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0136 0.0135
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.007 0.0133 0.0133
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0061 0.0113 0.5
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0269 0.0612 0.0612
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.055 0.055
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0269 0.0612 0.06
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0061 0.0113 0.0099
Loa Loa (eye worm) hypothetical protein 0.0037 0.0054 0.0054
Onchocerca volvulus 0.0042 0.0066 0.0729
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0879 0.208 0.208
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0018 0.0005
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.008 0.0157 0.0157
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1399 0.333 0.333
Trichomonas vaginalis PIKK family atypical protein kinase 0.1399 0.333 0.333
Trichomonas vaginalis immunophilin, putative 0.0061 0.0113 0.0112
Schistosoma mansoni fkbp-rapamycin associated protein 0.0789 0.1863 0.1862
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0049 0.0015
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0022 0.0021
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4171 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0075 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0789 0.1863 0.1863
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0013 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.1399 0.333 0.333
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0269 0.0612 0.0777
Loa Loa (eye worm) beta-lactamase 0.0042 0.0066 0.0066
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0789 0.1863 0.1852
Loa Loa (eye worm) hypothetical protein 0.0046 0.0076 0.0076
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0269 0.0612 0.0612
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0043 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.061 0.1432 0.1432
Entamoeba histolytica protein kinase, putative 0.0032 0.0043 0.0029
Brugia malayi hypothetical protein 0.0046 0.0076 0.0075
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0013 0.0012
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0269 0.0612 0.06
Trichomonas vaginalis PIKK family atypical protein kinase 0.2492 0.5961 0.5961
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0049 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.2249 0.5375 0.5375
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0066 0.0066
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0066 0.0066
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4171 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0269 0.0612 0.9997
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0269 0.0612 0.06
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0066 0.0066
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0022 0.0021
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0789 0.1863 0.1852
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0269 0.0612 0.0612
Leishmania major phosphatidylinositol 3-kinase, putative 0.1399 0.333 0.3286
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0269 0.0612 0.0612
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0022 0.0021
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0066 0.0066
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.052 0.1215 0.1204
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0789 0.1863 0.1862
Echinococcus multilocularis GPCR, family 2 0.0037 0.0054 0.0053
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0022 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0042 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0143 0.031 0.031
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0136 0.0132
Brugia malayi intermediate filament protein 0.0032 0.0041 0.004
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3321 0.7955 0.7941
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0042 0.0066 0.0053
Loa Loa (eye worm) hypothetical protein 0.0035 0.0049 0.0049
Onchocerca volvulus Huntingtin homolog 0.0143 0.031 0.4722
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4171 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0066 0.0066
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0066 0.0066
Echinococcus granulosus nervana 2 0.002 0.0013 0.0012
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0022 0.0021
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0041 0.004
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0061 0.0113 0.0099
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0269 0.0612 0.0612
Loa Loa (eye worm) phosphatidylinositol 3 0.0269 0.0612 0.0612
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0022 0.0021
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0269 0.0612 0.0612
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0022 0.0022
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0269 0.0612 0.0612
Entamoeba histolytica hypothetical protein 0.0042 0.0066 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0046 0.0076 0.0076
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0013 0.0012
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4171 1 1
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0043 0.0042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0022 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.3102 0.7428 0.7428
Leishmania major hypothetical protein, unknown function 0.0269 0.0612 0.055
Schistosoma mansoni hypothetical protein 0.0037 0.0054 0.0053
Schistosoma mansoni lipoxygenase 0.0119 0.0252 0.0252
Trypanosoma cruzi target of rapamycin kinase 3 0.3321 0.7955 0.7952
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0269 0.0612 0.055
Entamoeba histolytica hypothetical protein 0.0042 0.0066 0.0053
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0022 0.0021
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0061 0.0113 0.0099
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0061 0.0113 0.0112
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0022 0.0021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0789 0.1863 0.1862
Echinococcus granulosus lamin 0.0032 0.0041 0.004
Schistosoma mansoni rab6-interacting 0.0046 0.0076 0.0075
Schistosoma mansoni lamin 0.0032 0.0041 0.004
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0022 0.0021
Onchocerca volvulus Huntingtin homolog 0.0143 0.031 0.4722
Onchocerca volvulus 0.0269 0.0612 0.9686
Leishmania major phosphatidylinositol 3-kinase, putative 0.0269 0.0612 0.055
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0269 0.0612 0.0612
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0054 0.0053
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0022 0.0021
Entamoeba histolytica hypothetical protein 0.0269 0.0612 0.06
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0061 0.0113 0.0112
Onchocerca volvulus 0.0042 0.0066 0.0729
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0202 0.0452 0.0452
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0066 0.0053
Schistosoma mansoni coup transcription factor 0.0024 0.0022 0.0021
Echinococcus multilocularis Zinc finger, PHD finger 0.0269 0.0612 0.0612
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1399 0.333 0.333
Echinococcus multilocularis lipoxygenase domain containing protein 0.0046 0.0076 0.0075
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0022 0.0021
Echinococcus multilocularis serine protein kinase ATM 0.0789 0.1863 0.1862
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0269 0.0612 0.0572
Leishmania major phosphatidylinositol 4-kinase, putative 0.0269 0.0612 0.055
Echinococcus multilocularis nervana 2 0.002 0.0013 0.0012
Entamoeba histolytica protein kinase, putative 0.0032 0.0043 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.4171 1 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0092 0.0092
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0269 0.0612 0.06
Loa Loa (eye worm) hypothetical protein 0.052 0.1215 0.1215
Echinococcus multilocularis musashi 0.0032 0.0041 0.004
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0061 0.0113 0.007
Brugia malayi hypothetical protein 0.0042 0.0066 0.0066
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0054 0.0053
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1732 0.4133 0.4108
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0269 0.0612 0.0612
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0013 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.1399 0.333 0.333
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0269 0.0612 0.0612
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0061 0.0113 0.0099
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0269 0.0612 0.06
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0043 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0022 0.0021
Giardia lamblia GTOR 0.4171 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0022 0.0021
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0092 0.0092
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0269 0.0612 0.0612
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0061 0.0113 0.007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0022 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.052 0.1215 0.1215
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1399 0.333 0.3286
Echinococcus multilocularis Polycystic kidney disease protein 0.0046 0.0076 0.0075
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0136 0.0135
Loa Loa (eye worm) phosphatidylinositol 3 0.4171 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0269 0.0612 0.0612
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0066 0.0066
Plasmodium falciparum LCCL domain-containing protein 0.0046 0.0076 0.1043
Onchocerca volvulus 0.0032 0.0041 0.0312
Echinococcus granulosus lipoxygenase domain containing protein 0.0046 0.0076 0.0075
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0022
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0075 0.0145 0.0144
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0017 0.0017
Trichomonas vaginalis esterase, putative 0.0042 0.0066 0.0066
Onchocerca volvulus 0.0269 0.0612 0.9686
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0022 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0022 0.0021

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 55.8 nM Cytotoxicity against human HT-29 cells after 48 hrs using resazurin by microplate fluorometer analysis ChEMBL. 22185476

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 22185476

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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