Detailed information for compound 1650511

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 284.27 | Formula: C14H12N4O3
  • H donors: 1 H acceptors: 3 LogP: 0.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c[nH]n2c1nc(cc2=O)c1ccncc1
  • InChi: 1S/C14H12N4O3/c1-2-21-14(20)10-8-16-18-12(19)7-11(17-13(10)18)9-3-5-15-6-4-9/h3-8,16H,2H2,1H3
  • InChiKey: IKIFANJBLBFWHU-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4 Starlite/ChEMBL No references
Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha Starlite/ChEMBL No references
Homo sapiens homeodomain interacting protein kinase 2 Starlite/ChEMBL No references
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL No references
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL No references
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL No references
Homo sapiens interleukin-1 receptor-associated kinase 4 Starlite/ChEMBL No references
Homo sapiens cell division cycle 7 Starlite/ChEMBL No references
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens CDC-like kinase 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K02214 cell division control protein CDC7, putative Get druggable targets OG5_129189 All targets in OG5_129189
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129189 All targets in OG5_129189
Theileria parva cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative Get druggable targets OG5_128641 All targets in OG5_128641
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) STE/STE20/MSN protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma japonicum expressed protein Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis homeodomain interacting protein kinase 3 Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus granulosus homeodomain interacting protein kinase 3 Get druggable targets OG5_129272 All targets in OG5_129272
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Giardia lamblia Kinase, CDC7 Get druggable targets OG5_129189 All targets in OG5_129189
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium knowlesi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08826 homeodomain interacting protein kinase, putative Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus serine:threonine protein kinase mig 15 Get druggable targets OG5_128641 All targets in OG5_128641
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CDC7 protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania major protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128641 All targets in OG5_128641
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei protein kinase A catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Cryptosporidium hominis protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania braziliensis protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Protein kinase DC2, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Homeodomain interacting protein kinase protein 1 Get druggable targets OG5_129272 All targets in OG5_129272
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania infantum protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Candida albicans hypothetical protein Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis Get druggable targets OG5_128641 All targets in OG5_128641
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Brugia malayi probable protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Candida albicans similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cAMP-dependent protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum IPR000437,Prokaryotic membrane lipoprotein lipid attachment site,domain-containing Get druggable targets OG5_128641 All targets in OG5_128641
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Mitogen-activated protein kinase kinase kinase kinase 4, putative Get druggable targets OG5_128641 All targets in OG5_128641
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0062 0.1011 0.7856
Loa Loa (eye worm) hypothetical protein 0.0013 0.0113 0.0085
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0035 0.0511 0.0485
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0157 0.1219
Leishmania major protein kinase, putative 0.0077 0.1287 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.1011 0.0986
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0077 0.1287 1
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0228 0.0307
Echinococcus multilocularis cyclin dependent kinase 1 0.0056 0.0902 0.1216
Schistosoma mansoni protein kinase 0.0107 0.1839 0.2479
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0013 0.0113 0.0152
Brugia malayi probable protein kinase 0.0107 0.1839 0.1815
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0208 0.3704 0.3685
Brugia malayi steroid hormone receptor 0.0013 0.0113 0.0083
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0197 0.3486 0.4698
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0838 0.113
Trypanosoma brucei cdc2-related kinase 1 0.0056 0.0902 0.7008
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0077 0.1287 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0228 0.0201
Echinococcus granulosus cyclin dependent kinase 5 0.0056 0.0902 0.1216
Echinococcus granulosus ecdysone induced protein 78C 0.0013 0.0113 0.0152
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0113 0.0152
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0053 0.0838 0.6512
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0056 0.0902 0.0877
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0053 0.0838 0.0811
Brugia malayi nuclear receptor NHR-88 0.0013 0.0113 0.0083
Echinococcus multilocularis 0.0072 0.1201 0.162
Loa Loa (eye worm) hypothetical protein 0.002 0.0228 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0013 0.0113 0.0085
Brugia malayi Cytochrome P450 family protein 0.0016 0.0157 0.0128
Echinococcus multilocularis CDC7 cell division cycle 7 0.0073 0.1209 0.1629
Brugia malayi hypothetical protein 0.002 0.0228 0.0199
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0035 0.0511 0.0689
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0902 0.1423
Loa Loa (eye worm) hypothetical protein 0.0013 0.0113 0.0085
Echinococcus multilocularis ecdysone induced protein 78C 0.0013 0.0113 0.0152
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0048 0.0753 0.1014
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0208 0.3704 0.4992
Giardia lamblia Kinase, CMGC GSK 0.0062 0.1011 0.3852
Schistosoma mansoni serine/threonine protein kinase 0.018 0.3182 0.429
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0062 0.1011 0.7856
Schistosoma mansoni rab6-interacting 0.002 0.0228 0.0307
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0013 0.0113 0.0152
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0035 0.0511 0.0689
Schistosoma mansoni retinoic acid receptor RXR 0.0013 0.0113 0.0152
Echinococcus multilocularis 0.0077 0.1281 0.1727
Plasmodium vivax serine/threonine kinase-1, putative 0.0077 0.1287 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0113 0.0085
Brugia malayi follicle stimulating hormone receptor 0.023 0.4097 0.4079
Giardia lamblia Kinase, CMGC CDK 0.0056 0.0902 0.1423
Plasmodium vivax glycogen synthase kinase 3, putative 0.0062 0.1011 0.7395
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0053 0.0838 0.113
Schistosoma mansoni hypothetical protein 0.0166 0.292 0.3936
Echinococcus granulosus RUN 0.002 0.0228 0.0307
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.1011 0.273
Echinococcus multilocularis protein kinase shaggy 0.0062 0.1011 0.1363
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0013 0.0113 0.0152
Trichomonas vaginalis CMGC family protein kinase 0.0073 0.1209 0.8259
Loa Loa (eye worm) hypothetical protein 0.0052 0.0816 0.0791
Leishmania major protein kinase, putative 0.0077 0.1287 1
Brugia malayi Cytochrome P450 family protein 0.0016 0.0157 0.0128
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0113 0.0152
Loa Loa (eye worm) AGC/PKA protein kinase 0.0053 0.0838 0.0813
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0032 0.0043
Giardia lamblia Kinase, CDC7 0.0073 0.1209 0.8259
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0197 0.3486 0.3466
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0228 0.0307
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0157 0.1219
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.003 0.0425 0.0573
Schistosoma mansoni steroid hormone receptor ad4bp 0.0013 0.0113 0.0152
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0077 0.1281 0.1257
Brugia malayi Protein kinase domain containing protein 0.0035 0.0511 0.0483
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0208 0.3704 0.3686
Brugia malayi hypothetical protein 0.002 0.0228 0.0199
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.003 0.0425 0.3306
Schistosoma mansoni protein kinase 0.0035 0.0511 0.0689
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0113 0.0152
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0053 0.0838 0.6512
Schistosoma mansoni serine/threonine protein kinase 0.0208 0.3704 0.4992
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0992 0.1337
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0013 0.0113 0.0083
Leishmania major protein kinase A catalytic subunit isoform 2 0.0053 0.0838 0.6512
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0077 0.1287 0.1263
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0872 0.6777
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0053 0.0838 0.113
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0157 0.013
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0208 0.3704 0.4992
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0035 0.0511 0.0689
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0157 0.1219
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0013 0.0113 0.0083
Entamoeba histolytica cell division protein kinase 2, putative 0.0056 0.0902 0.2435
Schistosoma mansoni coup transcription factor 0.0013 0.0113 0.0152
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0053 0.0838 0.5762
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.1209 0.1629
Echinococcus granulosus rho-associated protein kinase 1 0.018 0.3182 0.429
Loa Loa (eye worm) hypothetical protein 0.0013 0.0113 0.0085
Echinococcus granulosus Vam6:Vps39 protein 0.003 0.0425 0.0573
Echinococcus granulosus protein kinase 0.0077 0.1281 0.1727
Entamoeba histolytica cell division protein kinase 2, putative 0.0056 0.0902 0.2435
Onchocerca volvulus 0.003 0.0425 0.0927
Schistosoma mansoni polycystin 1-related 0.002 0.0228 0.0307
Trypanosoma cruzi cdc2-related kinase 3 0.0056 0.0902 0.7008
Echinococcus granulosus cyclin dependent kinase 0.0056 0.0902 0.1216
Loa Loa (eye worm) hypothetical protein 0.0013 0.0113 0.0085
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0077 0.1287 1
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.3486 0.4698
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.2021 0.2724
Echinococcus multilocularis cyclin dependent kinase 5 0.0056 0.0902 0.1216
Brugia malayi Protein kinase domain containing protein 0.0073 0.1209 0.1183
Brugia malayi intracellular kinase 0.0062 0.1011 0.0984
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0053 0.0838 0.113
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0035 0.0511 0.0689
Schistosoma mansoni rab6-interacting 0.002 0.0228 0.0307
Onchocerca volvulus 0.002 0.0228 0.0341
Loa Loa (eye worm) steroid hormone receptor 0.0013 0.0113 0.0085
Schistosoma mansoni protein kinase 0.0077 0.1281 0.1727
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0013 0.0113 0.0085
Schistosoma mansoni lipoxygenase 0.0082 0.1373 0.1851
Brugia malayi hypothetical protein 0.003 0.0425 0.0397
Echinococcus granulosus dual specificity protein kinase clk2 0.0077 0.1287 0.1735
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0398 0.0371
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.1011 0.273
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0228 0.0307
Echinococcus granulosus CDC7 cell division cycle 7 0.0073 0.1209 0.1629
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0013 0.0113 0.0083
Giardia lamblia Kinase, CMGC CDK 0.0056 0.0902 0.1423
Loa Loa (eye worm) hypothetical protein 0.0072 0.1201 0.1177
Giardia lamblia Kinase, CMGC GSK 0.0062 0.1011 0.3852
Onchocerca volvulus 0.0073 0.1209 0.325
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0077 0.1287 1
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0113 0.0152
Echinococcus multilocularis cyclin dependent kinase 1 0.0056 0.0902 0.1216
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0062 0.1011 0.1363
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0157 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0013 0.0113 0.0152
Trypanosoma cruzi cdc2-related kinase 1 0.0056 0.0902 0.7008
Trypanosoma cruzi cdc2-related kinase 3 0.0056 0.0902 0.7008
Onchocerca volvulus 0.002 0.0228 0.0341
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0113 0.0152
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0228 0.0307
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0166 0.292 0.3936
Loa Loa (eye worm) hypothetical protein 0.003 0.0425 0.0399
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0013 0.0113 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0013 0.0113 0.0085
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0013 0.0113 0.0152
Onchocerca volvulus 0.0073 0.1209 0.325
Onchocerca volvulus 0.0175 0.3097 0.8848
Schistosoma mansoni hypothetical protein 0.002 0.0228 0.0307
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0062 0.1011 0.1363
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0077 0.1287 1
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0228 0.1769
Loa Loa (eye worm) hypothetical protein 0.0053 0.0838 0.0813
Toxoplasma gondii AGC kinase 0.0053 0.0838 0.6512
Schistosoma mansoni cpg binding protein 0.003 0.0428 0.0577
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0197 0.3486 0.3468
Brugia malayi cell division control protein 2 homolog 0.0056 0.0902 0.0875
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0902 0.1216
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0838 0.2263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0013 0.0113 0.0085
Brugia malayi photoreceptor-specific nuclear receptor 0.0013 0.0113 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0013 0.0113 0.0083
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0053 0.0838 0.6512
Leishmania major protein kinase A catalytic subunit 0.0053 0.0838 0.6512
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0053 0.0838 0.6512
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0013 0.0113 0.0152
Echinococcus multilocularis RUN 0.002 0.0228 0.0307
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.055 1 1
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0062 0.1011 0.1363
Echinococcus granulosus hypothetical protein 0.0072 0.1201 0.162
Echinococcus multilocularis dnaJ subfamily B 0.041 0.7419 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0013 0.0113 0.0083
Echinococcus granulosus FTZ F1 alpha 0.0013 0.0113 0.0152
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0511 0.0689
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.003 0.0425 0.3306
Onchocerca volvulus 0.0062 0.1011 0.2663
Loa Loa (eye worm) CDC7 protein kinase 0.0073 0.1209 0.1184
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0228 0.0307
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0053 0.0838 0.6512
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0838 0.113
Onchocerca volvulus 0.018 0.3182 0.9101
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0013 0.0113 0.0152
Leishmania major protein kinase A catalytic subunit isoform 1 0.0053 0.0838 0.6512
Loa Loa (eye worm) hypothetical protein 0.0013 0.0113 0.0085
Brugia malayi Doublecortin family protein 0.002 0.0228 0.0199
Echinococcus granulosus protein kinase shaggy 0.0062 0.1011 0.1363
Entamoeba histolytica protein kinase domain containing protein 0.0208 0.3704 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0179 0.3165 0.4267
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0013 0.0113 0.0152
Brugia malayi nuclear hormone receptor 0.0013 0.0113 0.0083
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0056 0.0902 0.7008
Giardia lamblia Kinase, CMGC CLK 0.0077 0.1287 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0056 0.0902 0.0877
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.1287 0.1735
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0053 0.0838 0.6512
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0197 0.3486 0.3468
Echinococcus multilocularis cyclin dependent kinase 0.0056 0.0902 0.1216
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.1011 0.0986
Brugia malayi Protein kinase domain containing protein 0.0056 0.0902 0.0875
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0157 0.013
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0035 0.0511 0.0689
Loa Loa (eye worm) hypothetical protein 0.003 0.0425 0.0399
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.003 0.0425 0.3306
Schistosoma mansoni rap gtpase-activating protein 0.003 0.0425 0.0573
Loa Loa (eye worm) hypothetical protein 0.0013 0.0113 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0013 0.0113 0.0083
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0053 0.0838 0.6512
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0035 0.0511 0.0689
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0838 0.2263
Echinococcus granulosus cyclin dependent kinase 1 0.0056 0.0902 0.1216
Brugia malayi CXXC zinc finger family protein 0.0029 0.0398 0.0369
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0013 0.0113 0.0152
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.003 0.0425 0.0573
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0113 0.0083
Brugia malayi Steroid receptor seven-up type 2 0.0013 0.0113 0.0083
Schistosoma mansoni RAR-like nuclear receptor 0.0013 0.0113 0.0152
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.1287 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0032 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0013 0.0113 0.0083
Loa Loa (eye worm) hypothetical protein 0.0013 0.0113 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0013 0.0113 0.0083
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.003 0.0425 0.0573
Trichomonas vaginalis CMGC family protein kinase 0.0073 0.1209 0.8259
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0056 0.0902 0.0877
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.003 0.0425 0.0573
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0032 0.0043
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0902 0.1423
Loa Loa (eye worm) AGC/PKA protein kinase 0.0053 0.0838 0.0813
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0077 0.1287 1
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0838 0.113
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0902 0.1216
Echinococcus granulosus dnaJ subfamily B 0.041 0.7419 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0013 0.0113 0.0152
Schistosoma mansoni lipoxygenase 0.0117 0.2021 0.2724
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0511 0.0689
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0013 0.0113 0.0152
Leishmania major cytochrome p450-like protein 0.0016 0.0157 0.1219
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.1287 0.1735
Entamoeba histolytica protein kinase, putative 0.0062 0.1011 0.273
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0013 0.0113 0.0083
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0166 0.292 0.3936
Trichomonas vaginalis CMGC family protein kinase 0.0073 0.1209 0.8259
Echinococcus multilocularis FTZ F1 alpha 0.0013 0.0113 0.0152
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0053 0.0838 0.113
Schistosoma mansoni cpg binding protein 0.003 0.0428 0.0577
Schistosoma mansoni vam6/vps39 related 0.003 0.0425 0.0573
Schistosoma mansoni loxhd1 0.002 0.0228 0.0307
Plasmodium vivax protein kinase Crk2 0.0056 0.0902 0.6365
Schistosoma mansoni hypothetical protein 0.003 0.0425 0.0573
Brugia malayi Protein kinase domain containing protein 0.0197 0.3486 0.3466
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0077 0.1287 1
Onchocerca volvulus 0.0029 0.0398 0.0845
Trypanosoma brucei cdc2-related kinase 3 0.0056 0.0902 0.7008
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0053 0.0838 0.6512
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0062 0.1011 0.7856
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.2021 0.2724
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0013 0.0113 0.0152
Brugia malayi ecdysteroid receptor 0.0013 0.0113 0.0083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0113 0.0152
Schistosoma mansoni cpg binding protein 0.0029 0.0398 0.0536
Schistosoma mansoni thyroid hormone receptor 0.0179 0.3165 0.4267
Trypanosoma cruzi cdc2-related kinase 1 0.0056 0.0902 0.7008
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0053 0.0838 0.113
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0048 0.0753 0.1014
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0013 0.0113 0.0085
Loa Loa (eye worm) hypothetical protein 0.0102 0.1754 0.1731
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0053 0.0838 0.113
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0056 0.0902 0.1216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0013 0.0113 0.0085
Trypanosoma brucei protein kinase, putative 0.0062 0.1011 0.7856
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0013 0.0113 0.0152
Plasmodium falciparum glycogen synthase kinase 3 0.0062 0.1011 0.7856
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0053 0.0838 0.6512
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0056 0.0902 0.7008
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1011 0.3852
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0013 0.0113 0.0083
Plasmodium falciparum protein serine/threonine kinase-1 0.0077 0.1287 1
Brugia malayi Temporarily assigned gene name protein 59 0.003 0.0425 0.0397
Echinococcus multilocularis cpg binding protein 0.003 0.0428 0.0577
Echinococcus multilocularis dual specificity protein kinase clk2 0.0077 0.1287 0.1735
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0102 0.1754 0.2364
Brugia malayi Protein kinase domain containing protein 0.0077 0.1287 0.1261
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1011 0.3852
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0013 0.0113 0.0083
Schistosoma mansoni thyroid hormone receptor 0.0179 0.3165 0.4267
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0013 0.0113 0.0083
Plasmodium falciparum protein kinase 5 0.0056 0.0902 0.7008
Loa Loa (eye worm) hypothetical protein 0.003 0.0425 0.0399
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0902 0.1423
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0197 0.3486 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0013 0.0113 0.0152
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0053 0.0838 0.113
Schistosoma mansoni hypothetical protein 0.041 0.7419 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.4097 0.408
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0157 0.013
Toxoplasma gondii AGC kinase 0.0053 0.0838 0.6512
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0013 0.0113 0.0085
Echinococcus granulosus cpg binding protein 0.003 0.0428 0.0577
Echinococcus multilocularis rho associated protein kinase 0.018 0.3182 0.429
Loa Loa (eye worm) doublecortin family protein 0.002 0.0228 0.0201
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0197 0.3486 0.4698
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0228 0.0307
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0056 0.0902 0.7008

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) > 5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP4K4 ChEMBL. No reference
Ki (functional) > 5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: IRAK4 ChEMBL. No reference
Ki (functional) > 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK2 ChEMBL. No reference
Ki (functional) > 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKACA ChEMBL. No reference
Ki (functional) = 5.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PIM1 ChEMBL. No reference
Ki (functional) = 5.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ROCK2 ChEMBL. No reference
Ki (functional) = 6.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: GSK3B ChEMBL. No reference
Ki (functional) = 7.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: HIPK2 ChEMBL. No reference
Ki (functional) = 7.6 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CLK4 ChEMBL. No reference
Ki (functional) = 8.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDC7 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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