Detailed information for compound 165444

Basic information

Technical information
  • TDR Targets ID: 165444
  • Name: N-[4-hydroxy-3,5-bis(morpholin-4-ylmethyl)phe nyl]benzamide
  • MW: 411.494 | Formula: C23H29N3O4
  • H donors: 2 H acceptors: 2 LogP: 1.33 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)Nc1cc(CN2CCOCC2)c(c(c1)CN1CCOCC1)O
  • InChi: 1S/C23H29N3O4/c27-22-19(16-25-6-10-29-11-7-25)14-21(24-23(28)18-4-2-1-3-5-18)15-20(22)17-26-8-12-30-13-9-26/h1-5,14-15,27H,6-13,16-17H2,(H,24,28)
  • InChiKey: BENVZSMFIFYRBO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-hydroxy-3,5-bis(morpholinomethyl)phenyl]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.027 0.2656
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0056 0.0046
Echinococcus granulosus cpg binding protein 0.0031 0.0065 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0232 0.1969
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0081 0.0186
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0196 0.0187
Echinococcus multilocularis expressed protein 0.0035 0.0081 0.0072
Brugia malayi nuclear hormone receptor 0.003 0.0056 0.0128
Schistosoma mansoni cpg binding protein 0.0031 0.0065 0.0137
Brugia malayi Protein kinase domain containing protein 0.0023 0.0022 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0056 0.0128
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0057 0.013
Brugia malayi PXA domain containing protein 0.0039 0.0102 0.0232
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0022 0.0157
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0041 0.0112 0.2005
Echinococcus multilocularis glutamate receptor 2 0.0057 0.0196 0.0186
Toxoplasma gondii 6-phosphofructokinase 0.0058 0.0201 0.1659
Entamoeba histolytica hypothetical protein 0.0039 0.0103 0.1004
Treponema pallidum ATP-dependent DNA helicase 0.002 0.0007 0.0009
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0103 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0056 0.0128
Entamoeba histolytica hypothetical protein 0.0039 0.0103 0.1004
Leishmania major cathepsin L-like protease 0.0064 0.0232 0.1812
Loa Loa (eye worm) RGC/RGC protein kinase 0.0027 0.0044 0.0101
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0037 0.0093 0.1655
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0037 0.0093 0.262
Echinococcus multilocularis thyroid hormone receptor alpha 0.0296 0.1408 0.14
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0102 0.0232
Loa Loa (eye worm) hypothetical protein 0.0046 0.014 0.032
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.118 0.2726
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0056 0.0046
Schistosoma mansoni 6-phosphofructokinase 0.0215 0.1 0.2308
Mycobacterium ulcerans 6-phosphofructokinase 0.0215 0.1 0.8474
Echinococcus granulosus geminin 0.0175 0.0797 0.0788
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0127 0.0549 0.4626
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0056 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0128
Schistosoma mansoni rotamase 0.0035 0.0081 0.0174
Echinococcus granulosus excitatory amino acid transporter 2 0.0249 0.1172 0.1163
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0103 0.0224
Entamoeba histolytica hypothetical protein 0.0039 0.0102 0.099
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0101
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0017 0.0039
Loa Loa (eye worm) hypothetical protein 0.0039 0.0102 0.0232
Brugia malayi hypothetical protein 0.0027 0.0044 0.01
Echinococcus granulosus excitatory amino acid transporter 2 0.0249 0.1172 0.1163
Loa Loa (eye worm) hypothetical protein 0.0039 0.0102 0.0232
Schistosoma mansoni hypothetical protein 0.0037 0.0093 0.0201
Entamoeba histolytica hypothetical protein 0.0039 0.0102 0.099
Schistosoma mansoni protein kinase 0.0027 0.0044 0.0087
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0251 0.118 1
Onchocerca volvulus 0.1 0.4989 1
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0201 0.0404
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0201 0.046
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0102 0.0092
Loa Loa (eye worm) runx1 0.0056 0.019 0.0434
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0077 0.0476
Brugia malayi laminin-like protein K08C7.3 precursor 0.0023 0.0024 0.0055
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0083 0.0329 0.0753
Brugia malayi hypothetical protein 0.0039 0.0102 0.0232
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0232 0.227
Schistosoma mansoni hypothetical protein 0.0467 0.2277 0.5276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0232 0.1969
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0039 0.0104 0.0094
Schistosoma mansoni hypothetical protein 0.0024 0.0029 0.0051
Onchocerca volvulus Poor gastrulation protein homolog 0.0024 0.0029 0.0058
Trichomonas vaginalis rotamase, putative 0.0035 0.0081 0.0163
Schistosoma mansoni serine-rich repeat protein 0.0467 0.2277 0.5276
Loa Loa (eye worm) hypothetical protein 0.0037 0.0093 0.0213
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.0003 0.0027
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0201 0.6001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0251 0.118 1
Echinococcus multilocularis geminin 0.0175 0.0797 0.0788
Brugia malayi hypothetical protein 0.0446 0.2171 0.4965
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0201 0.196
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0037 0.0093 0.0213
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0145 0.0331
Onchocerca volvulus 0.0027 0.0044 0.0089
Schistosoma mansoni lipoxygenase 0.0057 0.0196 0.044
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0109 0.0869
Entamoeba histolytica hypothetical protein 0.0039 0.0103 0.1004
Echinococcus granulosus metabotropic glutamate receptor 2 0.0138 0.0607 0.0599
Brugia malayi CXXC zinc finger family protein 0.003 0.0057 0.013
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.1 0.2004
Loa Loa (eye worm) glutamate receptor 0.0162 0.073 0.167
Loa Loa (eye worm) hypothetical protein 0.0083 0.0329 0.0753
Trichomonas vaginalis rotamase, putative 0.0034 0.0077 0.0155
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0102 0.0232
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0093 0.0213
Schistosoma mansoni metabotropic glutamate receptor 0.0086 0.0342 0.078
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0201 0.0192
Brugia malayi Excitatory amino acid transporter 0.0249 0.1172 0.2679
Echinococcus multilocularis glutamate receptor 2 0.0058 0.0203 0.0194
Loa Loa (eye worm) RecQ helicase 0.0065 0.0237 0.0542
Brugia malayi laminin alpha chain 0.0023 0.0024 0.0055
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0162 0.1566
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0457 0.4481
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0249 0.1172 0.1163
Toxoplasma gondii aldehyde dehydrogenase 0.0251 0.118 1
Echinococcus multilocularis glutamate receptor 2 0.0084 0.0334 0.0325
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1076 0.1068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0056 0.0128
Loa Loa (eye worm) phosphofructokinase 0.0215 0.1 0.2286
Leishmania major hypothetical protein, conserved 0.0027 0.0044 0.0187
Brugia malayi follicle stimulating hormone receptor 0.0466 0.2275 0.5202
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.4171 0.4165
Brugia malayi phosphofructokinase 0.0215 0.1 0.2286
Loa Loa (eye worm) hypothetical protein 0.0037 0.0093 0.0213
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.013 0.0297
Loa Loa (eye worm) hypothetical protein 0.0197 0.0905 0.2071
Echinococcus granulosus leukotriene A 4 hydrolase 0.0259 0.1222 0.1213
Onchocerca volvulus 0.0127 0.0549 0.1101
Brugia malayi hypothetical protein 0.0039 0.0103 0.0235
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.006 0.0209 0.6256
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0259 0.1222 0.2824
Loa Loa (eye worm) glutamate receptor 1 0.0057 0.0196 0.0448
Trichomonas vaginalis DNA helicase recq1, putative 0.0065 0.0237 0.0475
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0093 0.1655
Echinococcus granulosus glutamate NMDA receptor subunit 0.0057 0.0196 0.0186
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0324 0.0741
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0138 0.0607 0.0599
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0056 0.0128
Schistosoma mansoni laminin gamma-3 chain 0.0023 0.0024 0.004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0056 0.0046
Brugia malayi Guanylyl cyclase protein 23 0.0027 0.0044 0.0101
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.118 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0102 0.0232
Echinococcus multilocularis excitatory amino acid transporter 2 0.0249 0.1172 0.1163
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0093 0.0213
Schistosoma mansoni intermediate filament proteins 0.0082 0.0324 0.0737
Schistosoma mansoni DNA helicase recq1 0.0039 0.0104 0.0226
Echinococcus multilocularis GPCR, family 3, C terminal 0.0024 0.0029 0.0019
Schistosoma mansoni DNA helicase recq5 0.0039 0.0104 0.0226
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0056 0.0046
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1986 1 1
Toxoplasma gondii thioredoxin reductase 0.0048 0.0148 0.1201
Entamoeba histolytica hypothetical protein 0.0039 0.0103 0.1004
Chlamydia trachomatis neutral amino acid transporter 0.011 0.0467 0.3968
Brugia malayi PXA domain containing protein 0.0039 0.0102 0.0232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0232 0.1969
Schistosoma mansoni coup transcription factor 0.003 0.0056 0.0114
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0037 0.0093 0.262
Schistosoma mansoni hypothetical protein 0.0423 0.2057 0.4766
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0201 0.1546
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0169 0.0767 0.1767
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0201 0.1706
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0037 0.0093 0.0738
Echinococcus granulosus lamin dm0 0.0082 0.0324 0.0315
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0201 0.0403
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0201 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0056 0.0128
Brugia malayi Bloom's syndrome protein homolog 0.0065 0.0237 0.0542
Loa Loa (eye worm) hypothetical protein 0.0037 0.0093 0.0213
Loa Loa (eye worm) hypothetical protein 0.0127 0.0549 0.1256
Schistosoma mansoni hypothetical protein 0.0023 0.0022 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0089 0.0178
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0044 0.1076
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0101
Echinococcus multilocularis tumor protein p63 0.0364 0.1757 0.1749
Trypanosoma brucei trypanothione reductase 0.0048 0.0148 0.1085
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0058 0.0201 0.0503
Onchocerca volvulus 0.003 0.0057 0.0114
Brugia malayi hypothetical protein 0.002 0.001 0.0022
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0867 0.4309 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0232 0.1969
Onchocerca volvulus 0.0037 0.0093 0.0187
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1076 0.1068
Echinococcus granulosus voltage dependent calcium channel subunit 0.0903 0.4497 0.4492
Echinococcus granulosus glutamate receptor 2 0.0058 0.0203 0.0194
Brugia malayi Zona pellucida-like domain containing protein 0.0037 0.0093 0.0213
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0081 0.0186
Mycobacterium ulcerans epimerase 0.0022 0.0017 0.0145
Echinococcus granulosus glutamate receptor subunit protein glur 0.0026 0.0037 0.0028
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0102 0.022
Leishmania major cathepsin L-like protease 0.0064 0.0232 0.1812
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0102 0.0232
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0056 0.0046
Onchocerca volvulus 0.0037 0.0093 0.0187
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0089 0.4412
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0519 0.5108
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0044 0.0317
Loa Loa (eye worm) hypothetical protein 0.0685 0.3387 0.7746
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0055
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0077 0.035
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0056 0.0114
Echinococcus granulosus Excitatory amino acid transporter 0.0249 0.1172 0.1163
Schistosoma mansoni glutamate receptor kainate 0.0118 0.0506 0.116
Echinococcus multilocularis Excitatory amino acid transporter 0.0249 0.1172 0.1163
Loa Loa (eye worm) hypothetical protein 0.0037 0.0093 0.0213
Echinococcus multilocularis cpg binding protein 0.0031 0.0065 0.0056
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0084 0.0334 0.0325
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0056 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0102 0.022
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0102 0.022
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0051
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0077 0.0602
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0089 0.0827
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0039 0.0104 0.0094
Schistosoma mansoni glutamate receptor NMDA 0.0084 0.0334 0.0761
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0457 0.3878
Plasmodium vivax glutathione reductase, putative 0.0048 0.0148 0.2649
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0089 0.0827
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.1172 0.1163
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0051 0.0167 0.0382
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.1 1
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.2057 0.205
Loa Loa (eye worm) hypothetical protein 0.004 0.0108 0.0246
Echinococcus multilocularis expressed protein 0.075 0.3716 0.371
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0201 0.1706
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0102 0.0092
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.1172 0.1163
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0145 0.0644 0.0636
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0201 0.046
Brugia malayi Receptor family ligand binding region containing protein 0.0051 0.0167 0.0382
Toxoplasma gondii kringle domain-containing protein 0.0023 0.0022 0.0133
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.1 1
Echinococcus multilocularis sodium:dicarboxylate symporter 0.011 0.0467 0.0458
Loa Loa (eye worm) hypothetical protein 0.0038 0.01 0.0228
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0083 0.0329 0.3176
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0251 0.118 0.1171
Brugia malayi 6-phosphofructokinase 0.0215 0.1 0.2286
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0145 0.0644 0.0636
Onchocerca volvulus 0.0082 0.0324 0.0649
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0102 0.0092
Plasmodium falciparum thioredoxin reductase 0.0048 0.0148 0.4321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0232 0.1969
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0232 0.1969
Entamoeba histolytica hypothetical protein 0.0027 0.0044 0.0416
Brugia malayi nuclear receptor NHR-88 0.003 0.0056 0.0128
Echinococcus multilocularis lamin 0.0082 0.0324 0.0315
Mycobacterium tuberculosis Probable reductase 0.0109 0.0457 0.3878
Loa Loa (eye worm) hypothetical protein 0.0053 0.0177 0.0404
Onchocerca volvulus 0.0082 0.0324 0.0649
Echinococcus granulosus glutamate receptor 2 0.0084 0.0334 0.0325
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0215 0.1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0056 0.0128
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0197 0.0905 0.0897
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0201 0.3632
Echinococcus multilocularis nmda type glutamate receptor 0.0027 0.0044 0.0035
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0056 0.0128
Plasmodium falciparum glutathione reductase 0.0048 0.0148 0.4321
Brugia malayi Metabotropic glutamate receptor precursor. 0.0162 0.073 0.167
Echinococcus granulosus slit 2 protein 0.0023 0.0024 0.0014
Brugia malayi Pre-SET motif family protein 0.0127 0.0549 0.1256
Leishmania major trypanothione reductase 0.0048 0.0148 0.1083
Onchocerca volvulus 0.002 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0101
Echinococcus granulosus tissue type plasminogen activator 0.0023 0.0022 0.0013
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0466 0.2275 0.5202
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0089 0.0575
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.027 0.0618
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0089 0.0203
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0056 0.0112
Loa Loa (eye worm) hypothetical protein 0.0024 0.0029 0.0066
Echinococcus multilocularis tyrosine kinase 0.0027 0.0044 0.0035
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.011 0.0467 0.1069
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0027 0.0044 0.0035
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0077 0.0712
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0089 0.0191
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0102 0.022
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0044 0.0375
Brugia malayi Glutamate receptor 1 precursor 0.0057 0.0196 0.0448
Brugia malayi Glutamate receptor 2 precursor 0.0057 0.0196 0.0448
Echinococcus granulosus sodium:dicarboxylate symporter 0.0249 0.1172 0.1163
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0022
Brugia malayi Cache domain containing protein 0.04 0.1938 0.4433
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0093 0.0213
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0017 0.0145
Brugia malayi steroid hormone receptor 0.003 0.0056 0.0128
Loa Loa (eye worm) hypothetical protein 0.0038 0.01 0.0228
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0044 0.1076
Loa Loa (eye worm) excitatory amino acid transporter 0.0249 0.1172 0.2679
Loa Loa (eye worm) hypothetical protein 0.0039 0.0102 0.0232
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0201 0.196
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1408 0.3256
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0056 0.0128
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.025 0.0565
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0087 0.0347 0.0338
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0102 0.0092
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0104 0.0827
Loa Loa (eye worm) CUTiclin-Like family member 0.0037 0.0093 0.0213
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0215 0.1 0.2528
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.011 0.0467 0.0458
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0232 0.1969
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0056 0.0114
Onchocerca volvulus 0.002 0.001 0.0019
Plasmodium falciparum thrombospondin-related anonymous protein 0.0037 0.0093 0.262
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0284 0.0649
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0131 0.1255
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0232 0.227
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0903 0.4497 0.4492
Loa Loa (eye worm) CUTiclin family member 0.0037 0.0093 0.0213
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0093 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0056 0.0128
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0879 0.4372 1
Plasmodium vivax SET domain protein, putative 0.0127 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0022
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0039 0.0104 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0056 0.0128
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0027 0.0044 0.0089
Chlamydia trachomatis glutamate symporter 0.0249 0.1172 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0145 0.0644 0.0636
Echinococcus granulosus nmda type glutamate receptor 0.0045 0.0134 0.0125
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0104 0.0237
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0055
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0102 0.0092
Echinococcus granulosus GPCR family 3 C terminal 0.0024 0.0029 0.0019
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0266 0.1258 0.1249
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0102 0.0092
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0037 0.0093 0.1655
Schistosoma mansoni slit 0.0023 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0128
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0329 0.5971
Echinococcus granulosus dnaJ subfamily B 0.0423 0.2057 0.205
Loa Loa (eye worm) hypothetical protein 0.0037 0.0093 0.0213
Echinococcus granulosus Excitatory amino acid transporter 0.0249 0.1172 0.1163
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0196 0.0187
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0437 0.2126 0.4925
Schistosoma mansoni hypothetical protein 0.0175 0.0797 0.1837
Leishmania major ATP-dependent phosphofructokinase 0.0215 0.1 0.8445
Schistosoma mansoni glutamate receptor AMPA 0.0057 0.0196 0.0439
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0102 0.0232
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0104 0.0237
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0089 0.0079
Echinococcus granulosus neutral amino acid transporter 0.0249 0.1172 0.1163
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0128
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0077 0.0747
Onchocerca volvulus 0.0037 0.0093 0.0187
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0148 0.0138
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0108 0.0098
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0102 0.0092
Brugia malayi Receptor family ligand binding region containing protein 0.0027 0.0044 0.0101
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0102 0.0232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0232 0.1969
Brugia malayi Thioredoxin reductase 0.0048 0.0148 0.0338
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0102 0.0092
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0056 0.0114
Schistosoma mansoni 6-phosphofructokinase 0.0215 0.1 0.2308
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0215 0.1 1
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0102 0.0092
Onchocerca volvulus 0.003 0.0056 0.0112
Brugia malayi hypothetical protein 0.0037 0.0093 0.0213
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0089 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0056 0.0128
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0093 0.0213
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0056 0.0128
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0201 0.1696
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0101
Schistosoma mansoni hypothetical protein 0.0266 0.1258 0.2908
Trichomonas vaginalis set domain proteins, putative 0.1 0.4989 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.027 0.2144
Echinococcus granulosus neutral amino acid transporter A 0.0249 0.1172 0.1163
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0201 0.0503
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.118 1
Toxoplasma gondii phosphofructokinase PFKII 0.0058 0.0201 0.1659
Brugia malayi hypothetical protein 0.0263 0.1242 0.284
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0232 0.1969
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0051 0.0167 0.0382
Echinococcus multilocularis excitatory amino acid transporter 2 0.0249 0.1172 0.1163
Echinococcus granulosus expressed protein 0.075 0.3716 0.371
Schistosoma mansoni blooms syndrome DNA helicase 0.0045 0.0136 0.0301
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0102 0.0092
Toxoplasma gondii microneme protein MIC2 0.0037 0.0093 0.0738
Treponema pallidum glutamate transporter 0.011 0.0467 0.1176
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0089 0.0178
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0056 0.0046
Entamoeba histolytica elongation factor-2 kinase, putative 0.0037 0.0093 0.0907
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0131 0.0942
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0093 0.0213
Onchocerca volvulus 0.0037 0.0093 0.0187
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0102 0.0232
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0093 0.0213
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0102 0.0232
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.027 0.0618
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.1 0.2004
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0017 0.0034
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.027 0.0261
Schistosoma mansoni lamin 0.0082 0.0324 0.0737
Echinococcus granulosus tyrosine kinase 0.0027 0.0044 0.0035
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0023 0.0024 0.0055
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0023 0.0024 0.004
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0089 0.0079
Loa Loa (eye worm) glutamate receptor 2 0.0057 0.0196 0.0448
Echinococcus granulosus excitatory amino acid transporter 3 0.0249 0.1172 0.1163
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0056 0.0112
Chlamydia trachomatis endonuclease IV 0.0083 0.0329 0.279
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0057 0.0196 0.0186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0039
Loa Loa (eye worm) RGC/RGC protein kinase 0.0027 0.0044 0.0101
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0044 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0102 0.0203
Brugia malayi EGF-like domain containing protein 0.0023 0.0024 0.0055
Brugia malayi Pre-SET motif family protein 0.0879 0.4372 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0056 0.0046
Schistosoma mansoni hypothetical protein 0.0047 0.0145 0.032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0056 0.0114
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0232 0.227
Echinococcus granulosus 6 phosphofructokinase 0.0215 0.1 0.0991
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0056 0.0046
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0102 0.0232
Entamoeba histolytica hypothetical protein, conserved 0.0037 0.0093 0.0907
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0148 0.0338
Echinococcus granulosus atrial natriuretic peptide receptor 0.0027 0.0044 0.0035
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0519 0.4399
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.1 0.2004
Schistosoma mansoni polycystin 1-related 0.002 0.001 0.0007
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0145 0.0644 0.0636
Brugia malayi hypothetical protein 0.002 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0101
Entamoeba histolytica hypothetical protein 0.0039 0.0102 0.099
Echinococcus multilocularis lamin dm0 0.0082 0.0324 0.0315
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0249 0.1172 0.2348
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0023 0.0022 0.0356
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0249 0.1172 0.1163
Brugia malayi metabotropic glutamate receptor type 2 0.0086 0.0342 0.0783
Loa Loa (eye worm) doublecortin family protein 0.002 0.001 0.0022
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0249 0.1172 0.2707
Echinococcus multilocularis pikachurin 0.0023 0.0024 0.0014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0055
Plasmodium vivax thrombospondin-related anonymous protein 0.0037 0.0093 0.1655
Brugia malayi ecdysteroid receptor 0.003 0.0056 0.0128
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0549 0.1261
Mycobacterium ulcerans hypothetical protein 0.0022 0.0017 0.0145
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0039 0.0104 0.0094
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0077 0.0712
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0128
Schistosoma mansoni hypothetical protein 0.0039 0.0103 0.0224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0232 0.1969
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0093 0.0187
Echinococcus granulosus collagen alpha 1VII chain 0.0037 0.0093 0.0084
Entamoeba histolytica hypothetical protein 0.0037 0.0093 0.0907
Schistosoma mansoni nuclear hormone receptor 0.003 0.0056 0.0114
Toxoplasma gondii endonuclease IV APN 0.0083 0.0329 0.2749
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0081 0.0163
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0083 0.0329 0.279
Loa Loa (eye worm) hypothetical protein 0.0446 0.2171 0.4965
Treponema pallidum 76K protein 0.0037 0.0093 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0102 0.0203
Onchocerca volvulus 0.0037 0.0093 0.0187
Loa Loa (eye worm) hypothetical protein 0.0082 0.0324 0.0741
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.013 0.0297
Schistosoma mansoni cell polarity protein 0.0023 0.0024 0.004
Loa Loa (eye worm) glutamate receptor 0.0059 0.0204 0.0466
Echinococcus granulosus bloom syndrome protein 0.0065 0.0237 0.0228
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0201 0.0403
Echinococcus multilocularis receptor type guanylyl cyclase 0.0027 0.0044 0.0035
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0215 0.1 0.8474
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0201 0.3631
Entamoeba histolytica hypothetical protein, conserved 0.0037 0.0093 0.0907
Echinococcus granulosus neutral amino acid transporter A 0.0249 0.1172 0.1163
Brugia malayi hypothetical protein 0.0119 0.0511 0.1168
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0102 0.0092
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0026 0.0037 0.0028
Loa Loa (eye worm) hypothetical protein 0.0039 0.0102 0.0232
Echinococcus multilocularis tissue type plasminogen activator 0.0023 0.0022 0.0013
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0026 0.0037 0.0028
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.027 0.0613
Onchocerca volvulus 0.0037 0.0093 0.0187
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0089 0.0079
Mycobacterium ulcerans endonuclease IV 0.0083 0.0329 0.279
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0215 0.1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0056 0.0114
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0102 0.022
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0089 0.0079
Loa Loa (eye worm) hypothetical protein 0.0446 0.2171 0.4965
Onchocerca volvulus 0.0037 0.0093 0.0187
Giardia lamblia Sgs1 DNA helicase, putative 0.0039 0.0104 0.5154
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0102 0.0203
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0056 0.0128
Onchocerca volvulus 0.0047 0.0145 0.029
Plasmodium falciparum cysteine repeat modular protein 1 0.0023 0.0022 0.0401
Echinococcus granulosus lamin 0.0082 0.0324 0.0315
Echinococcus multilocularis musashi 0.0082 0.0324 0.0315
Echinococcus multilocularis bloom syndrome protein 0.0065 0.0237 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0056 0.0128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0056 0.0046
Echinococcus granulosus receptor type guanylyl cyclase 0.0027 0.0044 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0102 0.022
Schistosoma mansoni lamin 0.0082 0.0324 0.0737
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0102 0.022
Schistosoma mansoni metabotropic glutamate receptor 0.0138 0.0607 0.1396
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0549 0.1261
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0056 0.0046
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.118 0.2726
Leishmania major cathepsin L-like protease 0.0064 0.0232 0.1812
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0106 0.0445 0.0436
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0056 0.0046
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0056 0.0114
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.027 0.237
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0204 0.1984
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0037 0.0093 0.1655
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.001 0.0122
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0519 0.4399
Schistosoma mansoni hypothetical protein 0.0026 0.0037 0.007
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0201 0.0404
Trichomonas vaginalis phosphofructokinase, putative 0.0215 0.1 0.2004
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0089 0.0862
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0127 0.0549 0.054
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0201 0.1991
Echinococcus granulosus metabotropic glutamate receptor 5 0.0197 0.0905 0.0897
Schistosoma mansoni ATP-binding cassette transporter 0.0057 0.0196 0.0439
Schistosoma mansoni tyrosine kinase 0.0027 0.0044 0.0087
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0324 0.0741
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0044 0.0751
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0148 0.1419
Schistosoma mansoni hypothetical protein 0.0037 0.0093 0.0201
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0102 0.0232
Schistosoma mansoni cpg binding protein 0.003 0.0057 0.0117
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0089 0.0178
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0089 0.0079
Schistosoma mansoni lozenge 0.0056 0.019 0.0426
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0127 0.0549 0.054
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0037 0.0093 0.0213
Loa Loa (eye worm) TK/ROR protein kinase 0.0023 0.0022 0.0051
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0058 0.0201 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.118 1
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0117 0.0107
Trypanosoma cruzi extracellular receptor, putative 0.0027 0.0044 0.0378
Echinococcus multilocularis 6 phosphofructokinase 0.0215 0.1 0.0991
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0056 0.0112
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0131 0.0263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0056 0.0128
Echinococcus granulosus FTZ F1 alpha 0.003 0.0056 0.0046
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0058 0.0201 0.0404
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0145 0.0644 0.0636
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0102 0.022
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0056 0.0128
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0117 0.0107
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0329 1
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0324 0.0741
Treponema pallidum hypothetical protein 0.0037 0.0093 0.0229
Schistosoma mansoni rab6-interacting 0.002 0.001 0.0007
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0087 0.0347 0.0338
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0019 0.0003 0.0027
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0087 0.0347 0.0338
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1408 0.3256
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0102 0.0232
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0027 0.0044 0.0101
Loa Loa (eye worm) hypothetical protein 0.0051 0.0167 0.0382
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0056 0.0114
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0201 0.0404
Echinococcus multilocularis nmda type glutamate receptor 0.0045 0.0134 0.0125
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0102 0.0092
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.027 0.0261
Entamoeba histolytica phosphofructokinase, putative 0.0215 0.1 1
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0007
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0104 0.0827
Leishmania major extracellular receptor, putative 0.0027 0.0044 0.019
Brugia malayi glutathione reductase 0.0048 0.0148 0.0338
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0102 0.022
Loa Loa (eye worm) hypothetical protein 0.0039 0.0102 0.0232
Loa Loa (eye worm) abnormal epIthelia family member 0.0023 0.0024 0.0055
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0039 0.0104 0.2948
Loa Loa (eye worm) RGC/RGC protein kinase 0.0027 0.0044 0.0101
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0102 0.022
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0101
Echinococcus granulosus tumor protein p63 0.0364 0.1757 0.1749
Echinococcus granulosus neurogenic locus notch protein 0.0023 0.0024 0.0014
Echinococcus granulosus nmda type glutamate receptor 0.0027 0.0044 0.0035
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0457 0.3878
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0056 0.0128
Schistosoma mansoni glutamate receptor AMPA 0.0057 0.0196 0.0439
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0037 0.0093 0.0213
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0084 0.0334 0.0325
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0128
Brugia malayi Kringle domain containing protein 0.0023 0.0022 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0127 0.0549 0.1261
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0024 0.0029 0.0066
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0102 0.022
Entamoeba histolytica recQ family helicase, putative 0.0044 0.0131 0.1289
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0102 0.022
Loa Loa (eye worm) hypothetical protein 0.0081 0.0316 0.0723
Loa Loa (eye worm) 6-phosphofructokinase 0.0215 0.1 0.2286
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0259 0.1222 0.2794
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0056 0.0128
Loa Loa (eye worm) 6-phosphofructokinase 0.0215 0.1 0.2286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0232 0.1969
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0145 0.0644 0.0636
Echinococcus granulosus histone lysine methyltransferase setb 0.0127 0.0549 0.054
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.01
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0058 0.0201 0.1991
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0093 0.0213
Echinococcus multilocularis Excitatory amino acid transporter 0.0249 0.1172 0.1163
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0266 0.1258 0.1249
Loa Loa (eye worm) hypothetical protein 0.0039 0.0104 0.0237
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0135 0.0592 0.1354
Loa Loa (eye worm) hypothetical protein 0.023 0.1076 0.2461
Echinococcus multilocularis neurogenic locus notch protein 0.0023 0.0024 0.0014
Echinococcus granulosus pikachurin 0.0023 0.0024 0.0014
Brugia malayi Zona pellucida-like domain containing protein 0.0037 0.0093 0.0213
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0148 0.0138
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.1172 0.1163
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0201 0.6
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0056 0.0128
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0093 0.0213
Brugia malayi 6-phosphofructokinase 0.0215 0.1 0.2286
Onchocerca volvulus 0.0053 0.0177 0.0354
Schistosoma mansoni glutamate receptor NMDA 0.0057 0.0196 0.0439
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0216 0.1781
Schistosoma mansoni glutamate receptor kainate 0.0057 0.0196 0.0439
Schistosoma mansoni rab6-interacting 0.002 0.001 0.0007
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0102 0.0092
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0103 0.0094
Echinococcus multilocularis Protein lozenge 0.0056 0.019 0.0181
Loa Loa (eye worm) hypothetical protein 0.0039 0.0102 0.0232
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0056 0.0128
Echinococcus multilocularis slit 2 protein 0.0023 0.0024 0.0014
Loa Loa (eye worm) hypothetical protein 0.0036 0.0089 0.0203
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0201 0.0404
Brugia malayi hypothetical protein 0.0039 0.0102 0.0232
Loa Loa (eye worm) hypothetical protein 0.0037 0.0093 0.0213
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0102 0.0092
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0128
Brugia malayi von Willebrand Factor 0.0037 0.0093 0.0213
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0039 0.0104 0.0237
Brugia malayi Cytochrome P450 family protein 0.0074 0.0284 0.0649
Schistosoma mansoni survival motor neuron protein 0.0047 0.0145 0.032
Schistosoma mansoni ap endonuclease 0.0058 0.0201 0.0452
Echinococcus multilocularis NMDA receptor 0.0087 0.0347 0.0338
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0102 0.0092
Echinococcus granulosus intermediate filament protein 0.0082 0.0324 0.0315
Loa Loa (eye worm) hypothetical protein 0.0037 0.0093 0.0213
Toxoplasma gondii exonuclease III APE 0.0058 0.0201 0.1659
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0102 0.0092
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0457 0.3878
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0089 0.0191
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0201 0.1647
Brugia malayi hypothetical protein 0.023 0.1076 0.2461
Onchocerca volvulus 0.0027 0.0044 0.0089
Schistosoma mansoni loxhd1 0.002 0.001 0.0007
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0121 0.0522 0.0513
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0037 0.0093 0.0084
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0056 0.0046
Loa Loa (eye worm) hypothetical protein 0.0037 0.0093 0.0213
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0249 0.1172 1
Loa Loa (eye worm) hypothetical protein 0.04 0.1938 0.4433
Brugia malayi Doublecortin family protein 0.002 0.001 0.0022
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0058 0.0201 0.6001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0201 0.0192
Loa Loa (eye worm) hypothetical protein 0.0037 0.0093 0.0213
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0024 0.0029 0.0058
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0102 0.022
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.011 0.0467 0.1069
Trichomonas vaginalis phosphofructokinase, putative 0.0058 0.0201 0.0404
Echinococcus multilocularis excitatory amino acid transporter 3 0.0249 0.1172 0.1163
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0148 0.2649
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0251 0.118 0.1171
Loa Loa (eye worm) hypothetical protein 0.0037 0.0093 0.0213
Schistosoma mansoni glutamate receptor kainate 0.0118 0.0506 0.116
Schistosoma mansoni cpg binding protein 0.0031 0.0065 0.0137
Loa Loa (eye worm) hypothetical protein 0.0037 0.0093 0.0213
Treponema pallidum glutamate/aspartate transporter 0.011 0.0467 0.1176
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0056 0.0046
Schistosoma mansoni ap endonuclease 0.0058 0.0201 0.0452
Entamoeba histolytica recQ family DNA helicase 0.002 0.0007 0.0039
Trichomonas vaginalis DNA helicase recq, putative 0.0065 0.0237 0.0475
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0249 0.1172 0.9931
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0102 0.0203
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0026 0.0037 0.0028
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0027 0.0044 0.0101
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0201 0.9998
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0102 0.022
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0089 0.047
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0056 0.0114
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0232 0.227
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0102 0.0203
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0017 0.0145
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0177 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0102 0.0203
Loa Loa (eye worm) hypothetical protein 0.0037 0.0093 0.0213
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0056 0.0128
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0015
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0795 0.3945 1
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0102 0.0092
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0131 0.0914
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0549 0.1261
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0102 0.0092
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0128
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0101
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0457 0.3878
Plasmodium vivax 6-phosphofructokinase, putative 0.0058 0.0201 0.3632
Loa Loa (eye worm) hypothetical protein 0.0037 0.0093 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0056 0.0128
Loa Loa (eye worm) hypothetical protein 0.0037 0.0093 0.0213
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.027 0.2656
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0519 0.4399
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0128
Echinococcus granulosus expressed protein 0.0035 0.0081 0.0072
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0056 0.0046
Schistosoma mansoni hypothetical protein 0.0175 0.0797 0.1837
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.027 0.2684
Schistosoma mansoni tyrosine kinase 0.0027 0.0044 0.0087
Onchocerca volvulus 0.0446 0.2171 0.4351
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0056 0.0114
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0058 0.0201 0.1696
Onchocerca volvulus 0.0023 0.0022 0.0045
Schistosoma mansoni lipoxygenase 0.002 0.001 0.0007
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0056 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0056 0.0128
Loa Loa (eye worm) glutathione reductase 0.0048 0.0148 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0102 0.0203
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0259 0.1222 0.1213
Brugia malayi hypothetical protein 0.0027 0.0044 0.0101
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0148 0.1251
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0102 0.0092
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0457 0.3878
Brugia malayi intermediate filament protein 0.0082 0.0324 0.0741
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0058 0.0201 0.1659
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0108 0.0098

Activities

Activity type Activity value Assay description Source Reference
Dose (functional) = 16.5 mg kg-1 Antiarrhythmic activity estimated by using the ouabain intoxicated dog model and the active dose of base in ouabain dog was reported. ChEMBL. 3973901

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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