Detailed information for compound 1656951

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 440.494 | Formula: C26H24N4O3
  • H donors: 3 H acceptors: 4 LogP: 4.17 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)c1ccc(cc1)/C=c/1\[nH]c(=O)/c(=C/c2nc[nH]c2C(C)(C)C)/[nH]c1=O
  • InChi: 1S/C26H24N4O3/c1-26(2,3)23-19(27-15-28-23)14-21-25(33)29-20(24(32)30-21)13-16-9-11-18(12-10-16)22(31)17-7-5-4-6-8-17/h4-15H,1-3H3,(H,27,28)(H,29,33)(H,30,32)/b20-13-,21-14-
  • InChiKey: DCQNWYMFIRSTPV-NMGXZBPKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0131 0.0584
Echinococcus multilocularis Tubulin beta 2C chain 0.0146 0.0528 0.0813
Brugia malayi CXXC zinc finger family protein 0.0028 0.0075 0.0103
Brugia malayi CHE-14 protein 0.0046 0.0143 0.0197
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0523 0.3477
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.0377 0.2518
Schistosoma mansoni transient receptor potential channel 4 0.0098 0.0343 0.2271
Trichomonas vaginalis tubulin, putative 0.0063 0.021 0.2031
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0514 0.1883
Loa Loa (eye worm) alpha-tubulin 0.0271 0.1008 0.8696
Trichomonas vaginalis tubulin, putative 0.0082 0.0284 0.2768
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0131 0.0467
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0233 0.0358
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0066 0.0268
Echinococcus multilocularis tubulin alpha chain 0.0271 0.1008 0.1555
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0067
Brugia malayi hypothetical protein 0.0039 0.0117 0.0161
Trypanosoma brucei beta tubulin 0.0146 0.0528 0.1935
Trypanosoma cruzi tubulin delta chain 0.0063 0.021 0.0762
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0195 0.1276
Onchocerca volvulus 0.0011 0.0008 0.0001
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0051
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0121 0.1162
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0157 0.1049
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0049 0.0169
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0049 0.0068
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.001 0.0007 0.001
Schistosoma mansoni multidrug resistance protein 0.001 0.0007 0.0018
Brugia malayi Tubulin alpha-2 chain 0.0271 0.1008 0.1389
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0079 0.0121
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0043 0.0131 0.0848
Toxoplasma gondii hypothetical protein 0.0048 0.0153 0.0551
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0007 0.001
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0008 0.001
Brugia malayi Tubulin beta chain 0.0063 0.021 0.029
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0143 0.0954
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0008 0.0011
Schistosoma mansoni alpha tubulin 0.0271 0.1008 0.6733
Chlamydia trachomatis protoporphyrinogen oxidase 0.0043 0.0131 0.1081
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0008 0.001
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0043 0.0131 0.0553
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0157 0.0217
Trypanosoma cruzi tubulin delta chain 0.0063 0.021 0.0762
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0308 0.1152 0.5019
Trypanosoma brucei beta tubulin 0.0146 0.0528 0.1935
Plasmodium vivax importin-beta 2, putative 0.0029 0.0079 0.0275
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0604 0.2291 1
Schistosoma mansoni tubulin subunit alpha 0.0271 0.1008 0.6733
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0523 0.3495
Schistosoma mansoni transient receptor potential channel 0.0098 0.0343 0.2271
Schistosoma mansoni hypothetical protein 0.0166 0.0606 0.4038
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0008 0.001
Entamoeba histolytica P-glycoprotein-2 0.001 0.0007 0.0026
Echinococcus multilocularis tubulin alpha 1C chain 0.0271 0.1008 0.1555
Plasmodium falciparum alpha tubulin 2 0.0271 0.1008 0.3713
Entamoeba histolytica tubulin family protein 0.0146 0.0528 0.521
Toxoplasma gondii beta-1 tubulin, putative 0.0146 0.0528 0.1935
Loa Loa (eye worm) hypothetical protein 0.0156 0.0568 0.4897
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0066 0.0268
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0565
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0066 0.0611
Trypanosoma brucei tubulin delta chain 0.0063 0.021 0.0762
Leishmania major hypothetical protein, conserved 0.0025 0.0065 0.0223
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0044 0.0137 0.0492
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0043 0.0131 0.0201
Brugia malayi hypothetical protein 0.0016 0.003 0.0042
Echinococcus multilocularis Tubulin beta 2C chain 0.0146 0.0528 0.0813
Entamoeba histolytica hypothetical protein 0.0039 0.0117 0.112
Loa Loa (eye worm) tubulin gamma chain 0.0146 0.0528 0.4548
Echinococcus granulosus expressed conserved protein 0.01 0.0352 0.2352
Schistosoma mansoni tubulin subunit beta 0.0146 0.0528 0.3508
Trypanosoma brucei beta tubulin 0.0146 0.0528 0.1935
Plasmodium vivax delta tubulin, putative 0.0063 0.021 0.0762
Echinococcus granulosus Tubulin beta 2C chain 0.0146 0.0528 0.3526
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0011 0.0071
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.001 0.0007 0.001
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.001 0.0006 0.0039
Echinococcus granulosus GPCR family 2 0.0049 0.0157 0.1049
Schistosoma mansoni tubulin subunit beta 0.0146 0.0528 0.3508
Loa Loa (eye worm) hypothetical protein 0.0025 0.0065 0.0556
Echinococcus multilocularis tubulin alpha 3 chain 0.0271 0.1008 0.1555
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0233 0.2003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0079 0.0677
Leishmania major importin beta-1 subunit, putative 0.0024 0.0058 0.0197
Plasmodium vivax tubulin gamma chain, putative 0.0146 0.0528 0.1935
Loa Loa (eye worm) tubulin alpha 2 0.0207 0.0765 0.6597
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.0331 0.0509
Echinococcus multilocularis Tubulin alpha 1 chain 0.0271 0.1008 0.1555
Trichomonas vaginalis tubulin epsilon chain, putative 0.0063 0.021 0.2031
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0008 0.001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0058 0.0506
Brugia malayi tubulin alpha-2 chain 0.0271 0.1008 0.1389
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0049 0.0166
Echinococcus multilocularis Tubulin beta 2C chain 0.0146 0.0528 0.0813
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0066 0.0091
Echinococcus multilocularis tubulin alpha chain 0.0271 0.1008 0.1555
Trypanosoma cruzi alpha tubulin, putative 0.0271 0.1008 0.3713
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0308 0.1152 0.4247
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0216 0.1441
Echinococcus multilocularis nibrin 0.0011 0.0008 0.0012
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0043 0.0131 0.0467
Leishmania major alpha tubulin 0.0271 0.1008 0.3713
Echinococcus multilocularis cpg binding protein 0.0029 0.0081 0.0124
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0712 0.2708 1
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0121 0.1162
Trichomonas vaginalis tubulin epsilon chain, putative 0.0146 0.0528 0.5198
Entamoeba histolytica P-glycoprotein-5 0.001 0.0007 0.0026
Trichomonas vaginalis tubulin alpha chain, putative 0.0082 0.0284 0.2768
Echinococcus multilocularis tubulin gamma 1 chain 0.0146 0.0528 0.0813
Leishmania major epsilon tubulin, putative 0.0146 0.0528 0.1935
Entamoeba histolytica hypothetical protein 0.0011 0.0008 0.0036
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0006 0.0009
Schistosoma mansoni hypothetical protein 0.0049 0.0157 0.1025
Brugia malayi Importin beta-1 subunit 0.0029 0.0079 0.0109
Echinococcus granulosus tubulin epsilon chain 0.0146 0.0528 0.3526
Brugia malayi beta-tubulin, identical 0.0146 0.0528 0.0727
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0067
Schistosoma mansoni hypothetical protein 0.0049 0.0157 0.1025
Brugia malayi Cell division protein ftsZ 0.0063 0.021 0.029
Schistosoma mansoni multidrug resistance protein 0.001 0.0007 0.0018
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.0377 0.371
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0066 0.2852
Giardia lamblia Replication factor C, subunit 1 0.0011 0.0008 0.0017
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0008 0.0016
Echinococcus multilocularis tubulin beta 1 chain 0.0146 0.0528 0.0813
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.001 0.0007 0.001
Loa Loa (eye worm) tubulin beta chain 0.0146 0.0528 0.4548
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Plasmodium falciparum multidrug resistance protein 1 0.001 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0058
Trichomonas vaginalis tubulin gamma chain, putative 0.0063 0.021 0.2031
Echinococcus multilocularis snurportin 1 0.031 0.1159 0.1788
Schistosoma mansoni topbp1 0.0011 0.0008 0.0025
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0058 0.0506
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0117 0.018
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0066 0.2852
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0079 0.0275
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0063 0.021 0.0762
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0165 0.0594
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0066 0.0268
Chlamydia trachomatis DNA ligase 0.0011 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0046 0.0143 0.1231
Leishmania major alpha tubulin 0.0271 0.1008 0.3713
Loa Loa (eye worm) tubulin beta chain 0.0063 0.021 0.1813
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0007 0.0045
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.0523 0.4508
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0157 0.0242
Brugia malayi DKFZp564C0469 protein 0.0011 0.0008 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0233 0.153
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0131 0.0873
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0007 0.0045
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0143 0.0954
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0005 0.0006
Echinococcus granulosus tubulin delta chain 0.0063 0.021 0.1405
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0007 0.001
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0058 0.0197
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0066 0.0091
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.001 0.0007 0.0058
Echinococcus multilocularis GPCR, family 2 0.0049 0.0157 0.0242
Echinococcus granulosus tar DNA binding protein 0.0069 0.0233 0.1553
Plasmodium falciparum telomerase reverse transcriptase 0.0712 0.2708 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0043 0.0131 0.0467
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0271 0.1008 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0063 0.021 0.2031
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0007 0.0045
Toxoplasma gondii beta tubulin 0.0146 0.0528 0.1935
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.1122 0.4133
Plasmodium falciparum protoporphyrinogen oxidase 0.0043 0.0131 0.0467
Brugia malayi topoisomerase 0.0011 0.0008 0.0011
Leishmania major p-glycoprotein 0.001 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0067
Mycobacterium ulcerans cell division protein FtsZ 0.0063 0.021 0.0901
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0079 0.0275
Brugia malayi SWIRM domain containing protein 0.0043 0.0131 0.018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0523 0.0806
Loa Loa (eye worm) hypothetical protein 0.0043 0.0131 0.1126
Onchocerca volvulus 0.0028 0.0075 0.0067
Brugia malayi tubulin alpha chain - mouse 0.0271 0.1008 0.1389
Schistosoma mansoni hypothetical protein 0.0044 0.0137 0.0887
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0378 0.052
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0049 0.0166
Echinococcus granulosus tubulin alpha chain 0.0271 0.1008 0.6742
Entamoeba histolytica P-glycoprotein-2, putative 0.001 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0056 0.0183 0.1572
Entamoeba histolytica P-glycoprotein 5, putative 0.001 0.0007 0.0026
Giardia lamblia Beta tubulin 0.0146 0.0528 0.1937
Plasmodium falciparum tubulin epsilon chain, putative 0.0146 0.0528 0.1935
Trichomonas vaginalis tubulin alpha chain, putative 0.0146 0.0528 0.5198
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Trypanosoma brucei zeta tubulin, putative 0.0063 0.021 0.0762
Schistosoma mansoni tubulin subunit beta 0.0146 0.0528 0.3508
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0007 0.0045
Leishmania major telomerase reverse transcriptase, putative 0.0712 0.2708 1
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0008 0.0014
Leishmania major UDP-galactopyranose mutase 0.0043 0.0131 0.0467
Loa Loa (eye worm) multidrug resistance protein 3 0.001 0.0007 0.0058
Echinococcus granulosus tubulin subunit beta 0.0146 0.0528 0.3526
Schistosoma mansoni tubulin subunit alpha 0.0063 0.021 0.1382
Leishmania major zeta tubulin, putative 0.0063 0.021 0.0762
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.0568 0.0782
Plasmodium vivax telomerase reverse transcriptase, putative 0.0712 0.2708 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0146 0.0528 0.5198
Plasmodium vivax multidrug resistance protein 1, putative 0.001 0.0007 0.001
Loa Loa (eye worm) RNA binding protein 0.0069 0.0233 0.2003
Loa Loa (eye worm) tubulin alpha 2 0.0207 0.0765 0.6597
Brugia malayi Tubulin alpha chain 0.0063 0.021 0.029
Entamoeba histolytica tubulin family protein 0.0146 0.0528 0.521
Mycobacterium ulcerans dehydrogenase 0.0043 0.0131 0.0553
Echinococcus granulosus Tubulin alpha 1 chain 0.0271 0.1008 0.6742
Leishmania major gamma-tubulin 0.0146 0.0528 0.1935
Echinococcus multilocularis protein dispatched 1 0.0052 0.0168 0.0258
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0008 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0066 0.0268
Trichomonas vaginalis tubulin beta chain, putative 0.0271 0.1008 1
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0041 0.0135
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.0331 0.2209
Schistosoma mansoni topbp1 0.0011 0.0008 0.0025
Toxoplasma gondii beta-tubulin, putative 0.0146 0.0528 0.1935
Brugia malayi hypothetical protein 0.0025 0.0065 0.0089
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0065 0.0223
Trypanosoma brucei alpha tubulin 0.0271 0.1008 0.3713
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0233 0.153
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0514 0.1883
Echinococcus multilocularis tubulin alpha chain 0.0271 0.1008 0.1555
Trichomonas vaginalis tubulin alpha chain, putative 0.0082 0.0284 0.2768
Schistosoma mansoni hypothetical protein 0.0044 0.0137 0.0887
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0107 0.0147
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0233 0.032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.035
Trichomonas vaginalis tubulin gamma chain, putative 0.0146 0.0528 0.5198
Trypanosoma brucei epsilon tubulin 0.0146 0.0528 0.1935
Echinococcus multilocularis peroxisome assembly protein 26 0.0271 0.1008 0.1555
Echinococcus multilocularis 0.0043 0.0131 0.0201
Schistosoma mansoni tubulin subunit beta 0.0146 0.0528 0.3508
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0308 0.1152 1
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0008 0.0014
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0066 0.0268
Brugia malayi TAR-binding protein 0.0069 0.0233 0.032
Plasmodium vivax tubulin epsilon chain, putative 0.0146 0.0528 0.1935
Loa Loa (eye worm) hypothetical protein 0.0107 0.0378 0.3257
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0308 0.1152 0.5401
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0065 0.0223
Loa Loa (eye worm) hypothetical protein 0.0061 0.0203 0.1751
Trichomonas vaginalis tubulin gamma chain, putative 0.0146 0.0528 0.5198
Plasmodium falciparum tubulin beta chain 0.0146 0.0528 0.1935
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0005 0.0006
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.1159 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0007 0.001
Echinococcus granulosus geminin 0.0166 0.0606 0.4054
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0049 0.0328
Loa Loa (eye worm) hypothetical protein 0.0043 0.0131 0.1126
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0065 0.0223
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0523 0.0806
Schistosoma mansoni tubulin subunit beta 0.0146 0.0528 0.3508
Trypanosoma cruzi zeta tubulin, putative 0.0063 0.021 0.0762
Trypanosoma brucei epsilon tubulin 0.0146 0.0528 0.1935
Schistosoma mansoni hypothetical protein 0.0107 0.0378 0.2504
Trichomonas vaginalis tubulin beta chain, putative 0.0146 0.0528 0.5198
Brugia malayi ABC transporter family protein 0.001 0.0007 0.001
Brugia malayi Telomerase reverse transcriptase 0.1895 0.726 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0049 0.0447
Schistosoma mansoni tubulin subunit beta 0.0063 0.021 0.1382
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1693 0.6482 1
Schistosoma mansoni multidrug resistance protein 0.001 0.0007 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0233 0.153
Giardia lamblia Gamma tubulin 0.0146 0.0528 0.1937
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0067
Schistosoma mansoni tubulin subunit epsilon 0.0146 0.0528 0.3508
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0117 0.0779
Echinococcus multilocularis expressed conserved protein 0.01 0.0352 0.0543
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0143 0.1231
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.013 0.0462
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.0568 0.0782
Echinococcus multilocularis geminin 0.0166 0.0606 0.0935
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0066 0.0268
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.1495 0.2306
Brugia malayi alpha-tubulin 0.0271 0.1008 0.1389
Plasmodium falciparum importin beta, putative 0.0029 0.0079 0.0275
Leishmania major alpha tubulin 0.0271 0.1008 0.3713
Schistosoma mansoni ran 0.0021 0.0049 0.0301
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0007 0.001
Trypanosoma brucei alpha tubulin 0.0271 0.1008 0.3713
Plasmodium vivax tubulin beta chain, putative 0.0146 0.0528 0.1935
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Trichomonas vaginalis tubulin alpha chain, putative 0.0146 0.0528 0.5198
Echinococcus multilocularis transient receptor potential gamma protein 0.0098 0.0343 0.0529
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0008 0.001
Leishmania major alpha tubulin 0.0271 0.1008 0.3713
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.0377 0.0519
Loa Loa (eye worm) BEN-1 protein 0.0146 0.0528 0.4548
Echinococcus granulosus alpha tubulin 0.0271 0.1008 0.6742
Leishmania major alpha tubulin 0.0271 0.1008 0.3713
Loa Loa (eye worm) tubulin alpha chain 0.0271 0.1008 0.8696
Echinococcus granulosus tubulin alpha chain 0.0271 0.1008 0.6742
Entamoeba histolytica P-glycoprotein-1 0.001 0.0007 0.0026
Echinococcus multilocularis tubulin alpha chain 0.0271 0.1008 0.1555
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0066 0.0277
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0043 0.0131 0.0848
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0188 0.0691 0.6833
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0008 0.0011
Schistosoma mansoni DNA ligase IV 0.0011 0.0008 0.0025
Schistosoma mansoni hypothetical protein 0.0049 0.0157 0.1025
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0098 0.0343 0.2957
Brugia malayi Tubulin gamma chain 0.0146 0.0528 0.0727
Onchocerca volvulus 0.0082 0.0284 0.0277
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0157 0.1354
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0216 0.1441
Echinococcus granulosus tubulin subunit TubB 0.0271 0.1008 0.6742
Schistosoma mansoni ran 0.0021 0.0049 0.0301
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0049 0.0076
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0037 0.014
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0058
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0216 0.0332
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0008 0.0052
Brugia malayi Tubulin beta chain 0.0082 0.0284 0.0392
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0066 0.0611
Brugia malayi Tubulin beta-1 chain 0.0146 0.0528 0.0727
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.013 0.0462
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0121 0.1162
Schistosoma mansoni tubulin subunit alpha 0.0271 0.1008 0.6733
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0043 0.0131 0.6065
Schistosoma mansoni transient receptor potential channel 0.0065 0.0216 0.1417
Echinococcus multilocularis hypothetical protein 0.0271 0.1008 0.1555
Treponema pallidum cell division protein FtsZ 0.0063 0.021 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0146 0.0528 0.1935
Loa Loa (eye worm) tubulin alpha chain 0.0271 0.1008 0.8696
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0043 0.0131 0.0467
Leishmania major alpha tubulin 0.0271 0.1008 0.3713
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0712 0.2708 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0143 0.1357
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.035
Schistosoma mansoni tubulin subunit delta 0.0063 0.021 0.1382
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0131 0.0467
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0041 0.0295
Leishmania major delta tubulin, putative 0.0063 0.021 0.0762
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0514 0.1883
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.035
Plasmodium vivax tubulin alpha chain, putative 0.0271 0.1008 0.3713
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0008 0.0014
Toxoplasma gondii histone lysine-specific demethylase 0.0043 0.0131 0.0467
Trypanosoma cruzi epsilon tubulin, putative 0.0146 0.0528 0.1935
Loa Loa (eye worm) hypothetical protein 0.0043 0.0131 0.1126
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0005 0.0027
Trypanosoma brucei beta tubulin 0.0146 0.0528 0.1935
Schistosoma mansoni patched 1 0.0046 0.0143 0.0929
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0043 0.0131 0.0467
Echinococcus multilocularis protoporphyrinogen oxidase 0.0043 0.0131 0.0201
Schistosoma mansoni transient receptor potential channel 0.0065 0.0216 0.1417
Schistosoma mansoni tubulin subunit gamma 0.0146 0.0528 0.3508
Loa Loa (eye worm) hypothetical protein 0.0106 0.0377 0.3249
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0157 0.0242
Schistosoma mansoni importin beta-1 0.0029 0.0079 0.0499
Mycobacterium tuberculosis Possible oxidoreductase 0.0043 0.0131 0.0584
Schistosoma mansoni hypothetical protein 0.0044 0.0137 0.0887
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0308 0.1152 0.5019
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0005 0.0027
Loa Loa (eye worm) hypothetical protein 0.0271 0.1008 0.8696
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0561 0.2128 1
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0157 0.0217
Giardia lamblia Alpha-tubulin 0.0271 0.1008 0.3715
Leishmania major alpha tubulin 0.0271 0.1008 0.3713
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0117 0.0754
Entamoeba histolytica hypothetical protein 0.0039 0.0117 0.112
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0065 0.0223
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0067
Loa Loa (eye worm) hypothetical protein 0.0043 0.0131 0.1126
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0146 0.0528 0.0813
Loa Loa (eye worm) tubulin beta-4 chain 0.0146 0.0528 0.4548
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0065 0.0223
Trichomonas vaginalis tubulin, putative 0.0082 0.0284 0.2768
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0207 0.0765 0.757
Trypanosoma brucei beta tubulin 0.0146 0.0528 0.1935
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0107 0.0164
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0008 0.0014
Echinococcus granulosus beta tubulin 0.0146 0.0528 0.3526
Echinococcus granulosus transient receptor potential gamma protein 0.0098 0.0343 0.2292
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0067
Brugia malayi Tubulin alpha-2 chain 0.0271 0.1008 0.1389
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0063 0.021 0.0762
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0066 0.0277
Loa Loa (eye worm) hypothetical protein 0.0033 0.0094 0.0812
Echinococcus granulosus tubulin alpha chain 0.0271 0.1008 0.6742
Loa Loa (eye worm) tubulin alpha 2 0.0125 0.0448 0.3862
Echinococcus granulosus peroxisome assembly protein 26 0.0271 0.1008 0.6742
Trypanosoma brucei zeta tubulin 0.0063 0.021 0.0762
Entamoeba histolytica hypothetical protein 0.0024 0.0058 0.053
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.021 0.2031
Echinococcus granulosus tubulin beta 1 chain 0.0146 0.0528 0.3526
Mycobacterium ulcerans hypothetical protein 0.0026 0.0066 0.0268
Echinococcus granulosus tubulin alpha 3 chain 0.0271 0.1008 0.6742
Brugia malayi Tubulin alpha chain 0.0271 0.1008 0.1389
Brugia malayi RNA, U transporter 1 0.0083 0.0285 0.0392
Echinococcus multilocularis tubulin alpha 3 chain 0.0271 0.1008 0.1555
Echinococcus granulosus Tubulin beta 2C chain 0.0146 0.0528 0.3526
Echinococcus granulosus snurportin 1 0.031 0.1159 0.7752
Echinococcus multilocularis tubulin delta chain 0.0063 0.021 0.0324
Schistosoma mansoni cpg binding protein 0.0029 0.0081 0.0511
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0121 0.1162
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.0383 0.254
Echinococcus multilocularis Niemann Pick C1 protein 0.0152 0.0553 0.0852
Trypanosoma cruzi zeta tubulin, putative 0.0063 0.021 0.0762
Brugia malayi hypothetical protein 0.0011 0.0008 0.0011
Trypanosoma brucei telomerase reverse transcriptase 0.0712 0.2708 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0008 0.0037
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0308 0.1152 0.4247
Echinococcus multilocularis tubulin epsilon chain 0.0146 0.0528 0.0813
Echinococcus granulosus cpg binding protein 0.0029 0.0081 0.0537
Schistosoma mansoni hypothetical protein 0.0397 0.1495 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0188 0.0691 0.5961
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0233 0.2003
Echinococcus granulosus tubulin alpha 1C chain 0.0271 0.1008 0.6742
Schistosoma mansoni cpg binding protein 0.0028 0.0075 0.0469
Brugia malayi amine oxidase, flavin-containing family protein 0.0043 0.0131 0.018
Entamoeba histolytica hypothetical protein 0.0039 0.0117 0.112
Leishmania major alpha tubulin 0.0271 0.1008 0.3713
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.1122 0.4133
Schistosoma mansoni alpha tubulin 0.0271 0.1008 0.6733
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.0523 0.072
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0131 0.0467
Loa Loa (eye worm) hypothetical protein 0.0049 0.0157 0.1354
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0049 0.0166
Echinococcus multilocularis protein patched 0.0046 0.0143 0.022
Onchocerca volvulus 0.0026 0.0066 0.0059
Entamoeba histolytica P-glycoprotein-2 0.001 0.0007 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0066 0.0091
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0007 0.0045
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0207 0.0765 0.6597
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Loa Loa (eye worm) alpha-tubulin 0.0271 0.1008 0.8696
Schistosoma mansoni amine oxidase 0.0043 0.0131 0.0848
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Mycobacterium ulcerans hypothetical protein 0.0158 0.0575 0.2496
Echinococcus granulosus Tubulin beta 2C chain 0.0146 0.0528 0.3526
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.1122 0.4133
Mycobacterium ulcerans monoamine oxidase 0.0043 0.0131 0.0553
Schistosoma mansoni amine oxidase 0.0043 0.0131 0.0848
Giardia lamblia Beta tubulin 0.0146 0.0528 0.1937
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0066 0.0227
Echinococcus multilocularis beta tubulin 0.0146 0.0528 0.0813
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0308 0.1152 0.5019
Loa Loa (eye worm) hypothetical protein 0.0188 0.0691 0.5961
Mycobacterium leprae cell division protein FtsZ 0.0063 0.021 1
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0008 0.0025
Echinococcus granulosus Tubulin alpha 1 chain 0.0271 0.1008 0.6742
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0066 0.0268
Trypanosoma brucei alpha tubulin 0.0271 0.1008 0.3713
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0079 0.0275
Schistosoma mansoni cpg binding protein 0.0029 0.0081 0.0511
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0008 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0008 0.0014
Loa Loa (eye worm) beta-tubulin 0.0146 0.0528 0.4548
Leishmania major alpha tubulin 0.0271 0.1008 0.3713
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0171 0.0614
Giardia lamblia Alpha-tubulin 0.0271 0.1008 0.3715
Trichomonas vaginalis tubulin beta chain, putative 0.0271 0.1008 1
Echinococcus granulosus Tubulin beta 2C chain 0.0146 0.0528 0.3526
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0008 0.0014
Echinococcus granulosus nibrin 0.0011 0.0008 0.0052
Trypanosoma brucei tubulin gamma chain 0.0146 0.0528 0.1935
Giardia lamblia Epsilon tubulin 0.0063 0.021 0.0765
Schistosoma mansoni hypothetical protein 0.031 0.1159 0.7746
Trypanosoma cruzi beta tubulin, putative 0.0146 0.0528 0.1935
Trichomonas vaginalis tubulin, putative 0.0146 0.0528 0.5198
Schistosoma mansoni hypothetical protein 0.0039 0.0117 0.0754
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Brugia malayi hypothetical protein 0.0011 0.0008 0.0011
Schistosoma mansoni tubulin subunit alpha 0.0271 0.1008 0.6733
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0008 0.0014
Giardia lamblia Telomerase catalytic subunit 0.0712 0.2708 1
Leishmania major GTP-binding protein, putative 0.0021 0.0049 0.0166
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0008 0.0014
Schistosoma mansoni hypothetical protein 0.0044 0.0137 0.0887
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0523 0.3477
Giardia lamblia Delta tubulin 0.0063 0.021 0.0765
Echinococcus granulosus Niemann Pick C1 protein 0.0152 0.0553 0.3694
Echinococcus multilocularis Tubulin alpha 1 chain 0.0271 0.1008 0.1555
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0082 0.0284 0.2768
Echinococcus granulosus Tubulin alpha 1 chain 0.0271 0.1008 0.6742
Entamoeba histolytica tubulin gamma chain 0.0146 0.0528 0.521
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.035
Echinococcus granulosus tubulin gamma 1 chain 0.0146 0.0528 0.3526
Brugia malayi multidrug resistance protein 3 0.001 0.0007 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0037 0.014
Echinococcus multilocularis Tubulin beta 2C chain 0.0146 0.0528 0.0813
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0523 0.3495
Entamoeba histolytica P-glyco protein 6, putative 0.001 0.0007 0.0026
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0041 0.0135
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0308 0.1152 1
Plasmodium vivax tubulin alpha chain, putative 0.0271 0.1008 0.3713
Schistosoma mansoni tubulin subunit beta 0.0146 0.0528 0.3508
Trypanosoma brucei alpha tubulin 0.0271 0.1008 0.3713
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.0377 0.0581
Echinococcus granulosus tubulin alpha 1C chain 0.0271 0.1008 0.6742
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0107 0.0713
Leishmania major alpha tubulin 0.0271 0.1008 0.3713
Trypanosoma cruzi tubulin gamma chain 0.0146 0.0528 0.1935
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0058 0.0506
Echinococcus multilocularis tubulin alpha 1C chain 0.0271 0.1008 0.1555
Trichomonas vaginalis tubulin beta chain, putative 0.0271 0.1008 1
Brugia malayi RNA binding protein 0.0069 0.0233 0.032
Loa Loa (eye worm) hypothetical protein 0.0036 0.0107 0.092
Toxoplasma gondii RNA-directed DNA polymerase 0.0712 0.2708 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0041 0.0159
Onchocerca volvulus 0.0043 0.0131 0.0124
Echinococcus granulosus dnaJ subfamily B 0.0397 0.1495 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0049 0.0423
Loa Loa (eye worm) hypothetical protein 0.0043 0.0131 0.1126
Echinococcus granulosus tubulin alpha 3 chain 0.0271 0.1008 0.6742
Schistosoma mansoni hypothetical protein 0.0166 0.0606 0.4038
Loa Loa (eye worm) BEN-1 protein 0.0146 0.0528 0.4548
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.035
Plasmodium falciparum tubulin gamma chain 0.0146 0.0528 0.1935
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0075 0.0639
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0131 0.0873
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.0568 0.4897
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0049 0.0166
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0007 0.001
Trichomonas vaginalis tubulin beta chain, putative 0.0271 0.1008 1
Schistosoma mansoni alpha tubulin 0.0271 0.1008 0.6733
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.021 0.2031
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0216 0.0332
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Leishmania major alpha tubulin 0.0271 0.1008 0.3713
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0604 0.2291 1
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Entamoeba histolytica tubulin alpha chain, putative 0.0271 0.1008 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0041 0.0159
Loa Loa (eye worm) tubulin alpha-2 chain 0.0271 0.1008 0.8696
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0063 0.021 0.1768
Echinococcus multilocularis tubulin subunit beta 0.0146 0.0528 0.0813
Toxoplasma gondii alpha tubulin TUBA1 0.0271 0.1008 0.3713
Entamoeba histolytica hypothetical protein 0.0039 0.0117 0.112
Echinococcus granulosus tubulin alpha chain 0.0271 0.1008 0.6742
Schistosoma mansoni hypothetical protein 0.0011 0.0011 0.0043
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0008 0.001
Mycobacterium ulcerans oxidoreductase 0.0043 0.0131 0.0553
Echinococcus granulosus tubulin beta 4A class IVa 0.0146 0.0528 0.3526
Loa Loa (eye worm) tubulin beta-2A chain 0.0146 0.0528 0.4548
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0007 0.001
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.013 0.0462
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0066 0.0227
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.0575 0.2679
Echinococcus granulosus beta tubulin 0.0146 0.0528 0.3526
Trichomonas vaginalis tubulin alpha chain, putative 0.0082 0.0284 0.2768
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0008 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.013 0.0462
Trichomonas vaginalis tubulin beta chain, putative 0.0082 0.0284 0.2768
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0065 0.0223
Brugia malayi hypothetical protein 0.0043 0.0131 0.018
Echinococcus granulosus tubulin alpha 0.0146 0.0528 0.3526
Echinococcus granulosus importin subunit beta 1 0.0029 0.0079 0.0525
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0049 0.0166
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0007 0.0045
Entamoeba histolytica tubulin alpha-1 chain 0.0271 0.1008 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0007 0.0045
Toxoplasma gondii alpha-tubulin I, putative 0.0271 0.1008 0.3713
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0131 0.0467
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0005 0.0006
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0066 0.0611
Trypanosoma brucei epsilon tubulin 0.0146 0.0528 0.1935
Loa Loa (eye worm) tubulin beta-1 chain 0.0146 0.0528 0.4548
Loa Loa (eye worm) hypothetical protein 0.0043 0.0131 0.1126
Echinococcus multilocularis tubulin alpha chain 0.0271 0.1008 0.1555
Echinococcus multilocularis Tubulin alpha 1 chain 0.0271 0.1008 0.1555
Echinococcus multilocularis tubulin alpha 0.0146 0.0528 0.0813
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0049 0.0166
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0037 0.014
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0233 0.153
Trichomonas vaginalis ran, putative 0.0021 0.0049 0.0422
Trichomonas vaginalis tubulin beta chain, putative 0.0271 0.1008 1
Schistosoma mansoni smdr2 0.001 0.0007 0.0018
Echinococcus granulosus tubulin alpha chain 0.0271 0.1008 0.6742
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0066 0.0227
Schistosoma mansoni hypothetical protein 0.0049 0.0157 0.1025
Plasmodium falciparum tubulin delta chain, putative 0.0063 0.021 0.0762
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0065 0.0223
Echinococcus multilocularis Tubulin beta 2C chain 0.0146 0.0528 0.0813
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0565
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0005 0.0027
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0008 0.0014
Echinococcus multilocularis tubulin subunit TubB 0.0271 0.1008 0.1555
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0007 0.001
Trichomonas vaginalis tubulin epsilon chain, putative 0.0271 0.1008 1
Trypanosoma cruzi epsilon tubulin, putative 0.0146 0.0528 0.1935
Leishmania major alpha tubulin 0.0271 0.1008 0.3713
Leishmania major beta tubulin 0.0146 0.0528 0.1935
Trypanosoma brucei alpha tubulin, putative 0.0082 0.0284 0.1035
Trichomonas vaginalis tubulin epsilon chain, putative 0.0271 0.1008 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0157 0.1049
Plasmodium falciparum alpha tubulin 1 0.0271 0.1008 0.3713
Echinococcus multilocularis beta tubulin 0.0146 0.0528 0.0813
Giardia lamblia Beta tubulin 0.0146 0.0528 0.1937
Trichomonas vaginalis tubulin beta chain, putative 0.0271 0.1008 1
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0121 0.1162
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0207 0.0765 0.6597
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0233 0.153
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0143 0.022
Trichomonas vaginalis tubulin epsilon chain, putative 0.0146 0.0528 0.5198
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0565
Echinococcus granulosus Tubulin beta 2C chain 0.0146 0.0528 0.3526
Leishmania major mitochondrial DNA polymerase beta 0.03 0.1122 0.4133
Mycobacterium tuberculosis Cell division protein FtsZ 0.0063 0.021 0.0959
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0037 0.014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0523 0.3477

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1200 nM Cytotoxicity against human HT-29 cells after 48 hrs by XTT assay ChEMBL. 22727370

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 22727370

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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