Detailed information for compound 1656958

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 563.049 | Formula: C23H23ClN6O5S2
  • H donors: 2 H acceptors: 5 LogP: 3.89 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: COCCOc1cc2c(ncnc2cc1OCCOC)Sc1nnc(s1)NC(=O)Nc1cccc(c1)Cl
  • InChi: 1S/C23H23ClN6O5S2/c1-32-6-8-34-18-11-16-17(12-19(18)35-9-7-33-2)25-13-26-20(16)36-23-30-29-22(37-23)28-21(31)27-15-5-3-4-14(24)10-15/h3-5,10-13H,6-9H2,1-2H3,(H2,27,28,29,31)
  • InChiKey: LDEGOJWDSVVKIY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) tubulin alpha 2 0.0126 0.0444 0.3869
Loa Loa (eye worm) TAR-binding protein 0.007 0.0234 0.2034
Schistosoma mansoni hypothetical protein 0.0049 0.0153 0.0988
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.1 1
Echinococcus granulosus tubulin alpha chain 0.0273 0.1 0.6655
Brugia malayi ShTK domain containing protein 0.009 0.0308 0.0424
Toxoplasma gondii beta tubulin 0.0147 0.0523 0.1919
Brugia malayi Tubulin alpha-2 chain 0.0273 0.1 0.1378
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0057 0.0499
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0008 0.0038
Echinococcus multilocularis tubulin alpha chain 0.0273 0.1 0.1546
Loa Loa (eye worm) hypothetical protein 0.0042 0.0125 0.1082
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.1125 0.4145
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0548 0.2046 1
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.031 0.1141 0.5167
Loa Loa (eye worm) hypothetical protein 0.0155 0.0553 0.482
Echinococcus granulosus tubulin epsilon chain 0.0147 0.0523 0.348
Schistosoma mansoni tubulin subunit alpha 0.0273 0.1 0.6646
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0007 0.0045
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0066 0.0281
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0037 0.0147
Schistosoma mansoni tubulin subunit alpha 0.0064 0.0209 0.1362
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0144 0.0222
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0007 0.0045
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.0518 0.0713
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0119 0.1155
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0008 0.0011
Echinococcus multilocularis snurportin 1 0.0311 0.1147 0.1774
Echinococcus multilocularis Tubulin alpha 1 chain 0.0273 0.1 0.1546
Echinococcus multilocularis beta tubulin 0.0147 0.0523 0.0808
Schistosoma mansoni tar DNA-binding protein 0.007 0.0234 0.153
Trichomonas vaginalis tubulin gamma chain, putative 0.0064 0.0209 0.2028
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Trichomonas vaginalis tubulin epsilon chain, putative 0.0064 0.0209 0.2028
Entamoeba histolytica P-glyco protein 6, putative 0.0011 0.0007 0.0026
Toxoplasma gondii histone lysine-specific demethylase 0.0042 0.0125 0.0444
Giardia lamblia Alpha-tubulin 0.0273 0.1 0.3686
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0064 0.0219
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0209 0.0759 0.6612
Brugia malayi Niemann-Pick C1 protein precursor 0.0109 0.0379 0.0522
Echinococcus granulosus GPCR family 2 0.0049 0.0153 0.1013
Schistosoma mansoni tubulin subunit delta 0.0064 0.0209 0.1362
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Loa Loa (eye worm) tubulin alpha 2 0.0209 0.0759 0.6612
Loa Loa (eye worm) hypothetical protein 0.0042 0.0125 0.1082
Loa Loa (eye worm) tubulin alpha chain 0.0273 0.1 0.8717
Echinococcus multilocularis tubulin gamma 1 chain 0.0147 0.0523 0.0808
Leishmania major alpha tubulin 0.0273 0.1 0.3684
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0037 0.0147
Brugia malayi Tubulin beta chain 0.0064 0.0209 0.0287
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0066 0.062
Leishmania major hypothetical protein, conserved 0.0025 0.0064 0.0219
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0064 0.0209 0.0755
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0048 0.032
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0155 0.0555 0.0858
Entamoeba histolytica P-glycoprotein-2 0.0011 0.0007 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0008 0.0011
Brugia malayi topoisomerase 0.0011 0.0008 0.0011
Trichomonas vaginalis tubulin alpha chain, putative 0.0147 0.0523 0.5196
Echinococcus multilocularis hypothetical protein 0.0273 0.1 0.1546
Schistosoma mansoni hypothetical protein 0.0049 0.0153 0.0988
Trypanosoma brucei zeta tubulin, putative 0.0064 0.0209 0.0755
Trypanosoma brucei tubulin gamma chain 0.0147 0.0523 0.1919
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0042 0.0125 0.0444
Trypanosoma cruzi epsilon tubulin, putative 0.0147 0.0523 0.1919
Entamoeba histolytica tubulin alpha-1 chain 0.0273 0.1 1
Echinococcus multilocularis tubulin alpha chain 0.0273 0.1 0.1546
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0518 0.08
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0041 0.0167
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0355
Schistosoma mansoni alpha tubulin 0.0273 0.1 0.6646
Schistosoma mansoni tubulin subunit alpha 0.0273 0.1 0.6646
Echinococcus multilocularis tubulin alpha chain 0.0273 0.1 0.1546
Schistosoma mansoni multidrug resistance protein 0.0011 0.0007 0.0018
Echinococcus multilocularis Tubulin alpha 1 chain 0.0273 0.1 0.1546
Brugia malayi hypothetical protein 0.0016 0.0029 0.0041
Schistosoma mansoni tubulin subunit beta 0.0147 0.0523 0.3462
Schistosoma mansoni hypothetical protein 0.004 0.0118 0.0754
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0105 0.0145
Brugia malayi CHE-14 protein 0.0047 0.0144 0.0198
Trichomonas vaginalis tubulin gamma chain, putative 0.0147 0.0523 0.5196
Leishmania major alpha tubulin 0.0273 0.1 0.3684
Trichomonas vaginalis tubulin beta chain, putative 0.0083 0.0282 0.2765
Schistosoma mansoni tubulin subunit alpha 0.0273 0.1 0.6646
Brugia malayi hypothetical protein 0.0025 0.0064 0.0088
Mycobacterium leprae cell division protein FtsZ 0.0064 0.0209 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0083 0.0282 0.2765
Schistosoma mansoni hypothetical protein 0.0045 0.0137 0.0887
Schistosoma mansoni tubulin subunit gamma 0.0147 0.0523 0.3462
Leishmania major GTP-binding protein, putative 0.0021 0.0048 0.0163
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0008 0.0014
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0144 0.125
Toxoplasma gondii alpha-tubulin I, putative 0.0273 0.1 0.3684
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0048 0.0163
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.0553 0.482
Echinococcus granulosus Niemann Pick C1 protein 0.0155 0.0555 0.3694
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0066 0.0091
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0008 0.0014
Trichomonas vaginalis tubulin epsilon chain, putative 0.0147 0.0523 0.5196
Echinococcus multilocularis expressed conserved protein 0.0102 0.0354 0.0546
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.1125 0.4145
Echinococcus granulosus Tubulin beta 2C chain 0.0147 0.0523 0.348
Trypanosoma brucei telomerase reverse transcriptase 0.0723 0.2707 1
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0008 0.0014
Chlamydia trachomatis DNA ligase 0.0011 0.0008 0.001
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0048 0.0163
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0066 0.0281
Toxoplasma gondii beta-1 tubulin, putative 0.0147 0.0523 0.1919
Loa Loa (eye worm) hypothetical protein 0.0042 0.0125 0.1082
Echinococcus granulosus geminin 0.0169 0.0608 0.4046
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.001 0.0067
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0119 0.1155
Brugia malayi Tubulin beta chain 0.0083 0.0282 0.0388
Trypanosoma brucei zeta tubulin 0.0064 0.0209 0.0755
Trichomonas vaginalis tubulin alpha chain, putative 0.0083 0.0282 0.2765
Loa Loa (eye worm) tubulin beta-4 chain 0.0147 0.0523 0.4557
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0075 0.0649
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0005 0.0027
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0064 0.0219
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0355
Schistosoma mansoni hypothetical protein 0.0049 0.0153 0.0988
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0064 0.0219
Entamoeba histolytica P-glycoprotein-2 0.0011 0.0007 0.0026
Trypanosoma brucei alpha tubulin, putative 0.0083 0.0282 0.1026
Loa Loa (eye worm) RNA binding protein 0.007 0.0234 0.2034
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.031 0.1141 0.4203
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0007 0.001
Onchocerca volvulus 0.0028 0.0075 0.0068
Echinococcus granulosus expressed conserved protein 0.0102 0.0354 0.2352
Echinococcus multilocularis Tubulin beta 2C chain 0.0147 0.0523 0.0808
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0066 0.0228
Echinococcus multilocularis protein dispatched 1 0.0053 0.0169 0.026
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0066 0.0281
Schistosoma mansoni tubulin subunit beta 0.0147 0.0523 0.3462
Giardia lamblia Beta tubulin 0.0147 0.0523 0.1921
Schistosoma mansoni tubulin subunit beta 0.0147 0.0523 0.3462
Echinococcus granulosus beta tubulin 0.0147 0.0523 0.348
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0119 0.1155
Echinococcus multilocularis Tubulin beta 2C chain 0.0147 0.0523 0.0808
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0005 0.0006
Trypanosoma cruzi alpha tubulin, putative 0.0273 0.1 0.3684
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.013 0.0464
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Brugia malayi alpha-tubulin 0.0273 0.1 0.1378
Brugia malayi Tubulin alpha chain 0.0064 0.0209 0.0287
Schistosoma mansoni tubulin subunit beta 0.0147 0.0523 0.3462
Schistosoma mansoni transient receptor potential channel 4 0.0098 0.0339 0.2234
Trichomonas vaginalis tubulin, putative 0.0083 0.0282 0.2765
Echinococcus granulosus transient receptor potential ion channel A 0.0095 0.0327 0.2173
Giardia lamblia Beta tubulin 0.0147 0.0523 0.1921
Trypanosoma brucei beta tubulin 0.0147 0.0523 0.1919
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0209 0.2028
Loa Loa (eye worm) tubulin beta-2A chain 0.0147 0.0523 0.4557
Echinococcus multilocularis tubulin alpha 3 chain 0.0273 0.1 0.1546
Schistosoma mansoni tubulin subunit beta 0.0064 0.0209 0.1362
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0066 0.0091
Loa Loa (eye worm) hypothetical protein 0.0042 0.0125 0.1082
Echinococcus multilocularis transient receptor potential ion channel A 0.0095 0.0327 0.0505
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0066 0.0281
Loa Loa (eye worm) BEN-1 protein 0.0147 0.0523 0.4557
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0144 0.0954
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.0515 0.1889
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0064 0.0219
Echinococcus granulosus lysine specific histone demethylase 1A 0.0042 0.0125 0.0826
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0066 0.0281
Loa Loa (eye worm) hypothetical protein 0.0042 0.0125 0.1082
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0005 0.0027
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.0308 0.0424
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0008 0.0011
Schistosoma mansoni hypothetical protein 0.0049 0.0153 0.0988
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0066 0.029
Trichomonas vaginalis tubulin epsilon chain, putative 0.0147 0.0523 0.5196
Entamoeba histolytica hypothetical protein 0.004 0.0118 0.1135
Trichomonas vaginalis tubulin, putative 0.0083 0.0282 0.2765
Echinococcus multilocularis tar DNA binding protein 0.007 0.0234 0.0361
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0007 0.0045
Loa Loa (eye worm) beta-tubulin 0.0147 0.0523 0.4557
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0008 0.0011
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Leishmania major alpha tubulin 0.0273 0.1 0.3684
Schistosoma mansoni ran 0.0021 0.0048 0.0293
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0355
Leishmania major alpha tubulin 0.0273 0.1 0.3684
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0078 0.0271
Giardia lamblia Replication factor C, subunit 1 0.0011 0.0008 0.0017
Loa Loa (eye worm) tubulin alpha-3 chain 0.019 0.0686 0.5974
Entamoeba histolytica hypothetical protein 0.004 0.0118 0.1135
Trichomonas vaginalis tubulin gamma chain, putative 0.0147 0.0523 0.5196
Entamoeba histolytica P-glycoprotein-1 0.0011 0.0007 0.0026
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0007 0.0045
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.0308 0.0424
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0066 0.2895
Onchocerca volvulus 0.0042 0.0125 0.0117
Echinococcus granulosus Tubulin alpha 1 chain 0.0273 0.1 0.6655
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0118 0.0779
Trichomonas vaginalis tubulin epsilon chain, putative 0.0273 0.1 1
Schistosoma mansoni hypothetical protein 0.0169 0.0608 0.4029
Loa Loa (eye worm) hypothetical protein 0.0033 0.0093 0.0808
Brugia malayi tubulin alpha chain - mouse 0.0273 0.1 0.1378
Schistosoma mansoni tubulin subunit epsilon 0.0147 0.0523 0.3462
Echinococcus multilocularis tubulin alpha 0.0147 0.0523 0.0808
Echinococcus multilocularis Niemann Pick C1 protein 0.0109 0.0379 0.0585
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.059 0.2203 1
Brugia malayi Cell division protein ftsZ 0.0064 0.0209 0.0287
Entamoeba histolytica tubulin family protein 0.0147 0.0523 0.5209
Schistosoma mansoni tar DNA-binding protein 0.007 0.0234 0.153
Giardia lamblia Beta tubulin 0.0147 0.0523 0.1921
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0355
Mycobacterium ulcerans hypothetical protein 0.0161 0.0577 0.2604
Loa Loa (eye worm) alpha-tubulin 0.0273 0.1 0.8717
Echinococcus granulosus tubulin alpha chain 0.0273 0.1 0.6655
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0048 0.0163
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0213 0.0329
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0042 0.0125 0.0801
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.001 0.0006 0.0039
Loa Loa (eye worm) hypothetical protein 0.0106 0.0368 0.3203
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0058
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0007 0.0045
Treponema pallidum cell division protein FtsZ 0.0064 0.0209 1
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.0308 0.0424
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.1 1
Leishmania major alpha tubulin 0.0273 0.1 0.3684
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0234 0.2034
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0125 0.0444
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0011 0.0007 0.0058
Leishmania major alpha tubulin 0.0273 0.1 0.3684
Echinococcus granulosus tubulin alpha chain 0.0273 0.1 0.6655
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0518 0.3424
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0723 0.2707 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0066 0.029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0037 0.0147
Echinococcus multilocularis tubulin alpha 1C chain 0.0273 0.1 0.1546
Schistosoma mansoni transient receptor potential channel 0.0065 0.0213 0.1393
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0008 0.0012
Loa Loa (eye worm) tubulin beta chain 0.0064 0.0209 0.1814
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0144 0.1376
Echinococcus multilocularis GPCR, family 2 0.0049 0.0153 0.0235
Echinococcus multilocularis beta tubulin 0.0147 0.0523 0.0808
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.013 0.0464
Echinococcus granulosus tubulin alpha chain 0.0273 0.1 0.6655
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0042 0.0125 0.0801
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0518 0.3442
Echinococcus granulosus Tubulin alpha 1 chain 0.0273 0.1 0.6655
Echinococcus multilocularis protein patched 0.0047 0.0144 0.0222
Schistosoma mansoni cpg binding protein 0.003 0.0081 0.0511
Echinococcus granulosus tubulin delta chain 0.0064 0.0209 0.1385
Plasmodium vivax telomerase reverse transcriptase, putative 0.0723 0.2707 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0147 0.0523 0.0808
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0041 0.0136
Trypanosoma cruzi tubulin gamma chain 0.0147 0.0523 0.1919
Echinococcus multilocularis tubulin alpha 1C chain 0.0273 0.1 0.1546
Brugia malayi SWIRM domain containing protein 0.0042 0.0125 0.0172
Schistosoma mansoni hypothetical protein 0.0169 0.0608 0.4029
Trichomonas vaginalis tubulin, putative 0.0147 0.0523 0.5196
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0048 0.0163
Plasmodium vivax tubulin gamma chain, putative 0.0147 0.0523 0.1919
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0209 0.0759 0.7569
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0213 0.1417
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0153 0.1013
Giardia lamblia Telomerase catalytic subunit 0.0723 0.2707 1
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0008 0.0014
Trypanosoma cruzi UDP-galactopyranose mutase 0.0042 0.0125 0.0444
Brugia malayi DKFZp564C0469 protein 0.0011 0.0008 0.0011
Echinococcus multilocularis tubulin alpha chain 0.0273 0.1 0.1546
Trichomonas vaginalis ran, putative 0.0021 0.0048 0.0416
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0048 0.0166
Entamoeba histolytica tubulin family protein 0.0147 0.0523 0.5209
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0008 0.0014
Schistosoma mansoni DNA ligase IV 0.0011 0.0008 0.0025
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.031 0.1141 0.5167
Entamoeba histolytica P-glycoprotein-5 0.0011 0.0007 0.0026
Echinococcus granulosus tubulin beta 4A class IVa 0.0147 0.0523 0.348
Leishmania major zeta tubulin, putative 0.0064 0.0209 0.0755
Toxoplasma gondii alpha tubulin TUBA1 0.0273 0.1 0.3684
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0515 0.1889
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0064 0.0209 0.2028
Loa Loa (eye worm) alpha-tubulin 0.0273 0.1 0.8717
Onchocerca volvulus 0.009 0.0308 0.0301
Echinococcus granulosus Tubulin beta 2C chain 0.0147 0.0523 0.348
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0355
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Giardia lamblia Delta tubulin 0.0064 0.0209 0.0758
Echinococcus multilocularis nibrin 0.0011 0.0008 0.0012
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0153 0.1013
Brugia malayi RNA, U transporter 1 0.0083 0.0281 0.0388
Plasmodium falciparum tubulin epsilon chain, putative 0.0147 0.0523 0.1919
Plasmodium falciparum alpha tubulin 1 0.0273 0.1 0.3684
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0196 0.1277
Leishmania major alpha tubulin 0.0273 0.1 0.3684
Trichomonas vaginalis tubulin epsilon chain, putative 0.0273 0.1 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.001 0.0015
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0041 0.0136
Schistosoma mansoni tubulin subunit beta 0.0147 0.0523 0.3462
Echinococcus multilocularis 0.0042 0.0125 0.0192
Plasmodium vivax multidrug resistance protein 1, putative 0.0011 0.0007 0.001
Plasmodium falciparum protoporphyrinogen oxidase 0.0042 0.0125 0.0444
Trypanosoma cruzi tubulin delta chain 0.0064 0.0209 0.0755
Plasmodium falciparum telomerase reverse transcriptase 0.0723 0.2707 1
Echinococcus granulosus tubulin subunit beta 0.0147 0.0523 0.348
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Echinococcus granulosus cpg binding protein 0.003 0.0081 0.0537
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0008 0.0052
Schistosoma mansoni hypothetical protein 0.0045 0.0137 0.0887
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.1503 0.2323
Schistosoma mansoni importin beta-1 0.0029 0.0078 0.0488
Onchocerca volvulus 0.0011 0.0008 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0051
Entamoeba histolytica P-glycoprotein-2, putative 0.0011 0.0007 0.0026
Echinococcus granulosus importin subunit beta 1 0.0029 0.0078 0.0514
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Trypanosoma brucei tubulin delta chain 0.0064 0.0209 0.0755
Toxoplasma gondii hypothetical protein 0.0049 0.0154 0.0552
Brugia malayi CXXC zinc finger family protein 0.0028 0.0075 0.0103
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0064 0.0209 0.1769
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0008 0.0011
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.031 0.1141 0.5167
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0062 0.0201 0.1747
Trichomonas vaginalis tubulin, putative 0.0064 0.0209 0.2028
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0008 0.0011
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0042 0.0125 0.0444
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0048 0.0163
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0007 0.0045
Chlamydia trachomatis oxoacyl-ACP synthase III 0.031 0.1141 1
Leishmania major delta tubulin, putative 0.0064 0.0209 0.0755
Loa Loa (eye worm) multidrug resistance protein 3 0.0011 0.0007 0.0058
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0048 0.0163
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0153 0.021
Trypanosoma brucei alpha tubulin 0.0273 0.1 0.3684
Plasmodium falciparum tubulin delta chain, putative 0.0064 0.0209 0.0755
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0064 0.0552
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0213 0.0329
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0165 0.0596
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0518 0.3424
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0068
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0008 0.0014
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0042 0.0125 0.0444
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0007 0.001
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.1 1
Echinococcus granulosus tubulin gamma 1 chain 0.0147 0.0523 0.348
Schistosoma mansoni tar DNA-binding protein 0.007 0.0234 0.153
Plasmodium falciparum alpha tubulin 2 0.0273 0.1 0.3684
Echinococcus granulosus tubulin subunit TubB 0.0273 0.1 0.6655
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0048 0.0067
Echinococcus granulosus Tubulin beta 2C chain 0.0147 0.0523 0.348
Loa Loa (eye worm) tyrosinase 1 0.009 0.0308 0.268
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0078 0.0271
Loa Loa (eye worm) hypothetical protein 0.0042 0.0125 0.1082
Toxoplasma gondii beta-tubulin, putative 0.0147 0.0523 0.1919
Brugia malayi multidrug resistance protein 3 0.0011 0.0007 0.001
Leishmania major alpha tubulin 0.0273 0.1 0.3684
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0064 0.0219
Echinococcus granulosus tubulin alpha 0.0147 0.0523 0.348
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0008 0.0025
Brugia malayi beta-tubulin, identical 0.0147 0.0523 0.0721
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.0553 0.0762
Plasmodium vivax importin-beta 2, putative 0.0029 0.0078 0.0271
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0723 0.2707 1
Echinococcus multilocularis tubulin alpha chain 0.0273 0.1 0.1546
Echinococcus granulosus Tubulin alpha 1 chain 0.0273 0.1 0.6655
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0011 0.0007 0.001
Onchocerca volvulus 0.009 0.0308 0.0301
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0042 0.0125 0.0546
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0005 0.0027
Brugia malayi hypothetical protein 0.004 0.0118 0.0162
Loa Loa (eye worm) hypothetical protein 0.019 0.0686 0.5974
Echinococcus granulosus Niemann Pick C1 protein 0.0109 0.0379 0.2518
Mycobacterium ulcerans monoamine oxidase 0.0042 0.0125 0.0546
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0368 0.0507
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0007 0.001
Echinococcus granulosus tubulin alpha 3 chain 0.0273 0.1 0.6655
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0064 0.0219
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.019 0.0686 0.6832
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0007 0.001
Echinococcus multilocularis tubulin delta chain 0.0064 0.0209 0.0322
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0005 0.0006
Toxoplasma gondii RNA-directed DNA polymerase 0.0723 0.2707 1
Giardia lamblia Alpha-tubulin 0.0273 0.1 0.3686
Echinococcus granulosus nibrin 0.0011 0.0008 0.0052
Brugia malayi Tubulin alpha chain 0.0273 0.1 0.1378
Echinococcus granulosus beta tubulin 0.0147 0.0523 0.348
Loa Loa (eye worm) hypothetical protein 0.0057 0.0184 0.1596
Leishmania major importin beta-1 subunit, putative 0.0024 0.0057 0.0193
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0008 0.0017
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0057 0.0193
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0574
Giardia lamblia Gamma tubulin 0.0147 0.0523 0.1921
Trichomonas vaginalis tubulin beta chain, putative 0.0147 0.0523 0.5196
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0209 0.0759 0.6612
Leishmania major alpha tubulin 0.0273 0.1 0.3684
Mycobacterium ulcerans oxidoreductase 0.0042 0.0125 0.0546
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.1147 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0273 0.1 1
Leishmania major telomerase reverse transcriptase, putative 0.0723 0.2707 1
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Schistosoma mansoni cpg binding protein 0.0028 0.0075 0.047
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0125 0.0576
Brugia malayi amine oxidase, flavin-containing family protein 0.0042 0.0125 0.0172
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0057 0.0499
Echinococcus granulosus Tubulin beta 2C chain 0.0147 0.0523 0.348
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0144 0.0954
Loa Loa (eye worm) BEN-1 protein 0.0147 0.0523 0.4557
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0048 0.0419
Brugia malayi Importin beta-1 subunit 0.0029 0.0078 0.0107
Mycobacterium tuberculosis Possible oxidoreductase 0.0042 0.0125 0.0576
Echinococcus multilocularis geminin 0.0169 0.0608 0.094
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0066 0.0228
Echinococcus granulosus tubulin beta 1 chain 0.0147 0.0523 0.348
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.009 0.0308 0.0424
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1714 0.6468 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0098 0.0339 0.0524
Echinococcus granulosus transient receptor potential gamma protein 0.0098 0.0339 0.2255
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.059 0.2203 1
Entamoeba histolytica hypothetical protein 0.004 0.0118 0.1135
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0125 0.0444
Loa Loa (eye worm) hypothetical protein 0.009 0.0308 0.268
Trypanosoma brucei beta tubulin 0.0147 0.0523 0.1919
Loa Loa (eye worm) tubulin gamma chain 0.0147 0.0523 0.4557
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0083 0.0282 0.2765
Schistosoma mansoni hypothetical protein 0.0045 0.0137 0.0887
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0041 0.0167
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0058
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Leishmania major alpha tubulin 0.0273 0.1 0.3684
Trypanosoma brucei epsilon tubulin 0.0147 0.0523 0.1919
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0066 0.0228
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0041 0.03
Entamoeba histolytica hypothetical protein 0.0011 0.0008 0.0038
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0042 0.0125 0.0444
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0153 0.1326
Schistosoma mansoni topbp1 0.0011 0.0008 0.0025
Trypanosoma cruzi UDP-galactopyranose mutase 0.0042 0.0125 0.0444
Loa Loa (eye worm) tubulin alpha 2 0.0209 0.0759 0.6612
Onchocerca volvulus 0.0026 0.0066 0.0059
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0064 0.0209 0.0755
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0066 0.062
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0068
Schistosoma mansoni smdr2 0.0011 0.0007 0.0018
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0006 0.0009
Schistosoma mansoni transient receptor potential channel 0.0098 0.0339 0.2234
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0008 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0518 0.3424
Leishmania major p-glycoprotein 0.0011 0.0007 0.001
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0066 0.0281
Echinococcus multilocularis cpg binding protein 0.003 0.0081 0.0125
Entamoeba histolytica tubulin gamma chain 0.0147 0.0523 0.5209
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0153 0.0235
Loa Loa (eye worm) hypothetical protein 0.009 0.0308 0.268
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0066 0.0281
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.0308 0.268
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0574
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0147 0.0523 0.0808
Schistosoma mansoni amine oxidase 0.0042 0.0125 0.0801
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0066 0.0091
Brugia malayi RNA binding protein 0.007 0.0234 0.0322
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0007 0.001
Leishmania major alpha tubulin 0.0273 0.1 0.3684
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0037 0.0147
Plasmodium falciparum importin beta, putative 0.0029 0.0078 0.0271
Schistosoma mansoni tubulin subunit beta 0.0147 0.0523 0.3462
Echinococcus granulosus snurportin 1 0.0311 0.1147 0.7635
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.0047 0.0144 0.125
Mycobacterium ulcerans dehydrogenase 0.0042 0.0125 0.0546
Trypanosoma cruzi zeta tubulin, putative 0.0064 0.0209 0.0755
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0078 0.0271
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0008 0.0011
Schistosoma mansoni hypothetical protein 0.0405 0.1503 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0042 0.0125 0.0192
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.0577 0.2795
Trypanosoma brucei beta tubulin 0.0147 0.0523 0.1919
Brugia malayi Tubulin beta-1 chain 0.0147 0.0523 0.0721
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0153 0.0235
Echinococcus multilocularis tubulin subunit beta 0.0147 0.0523 0.0808
Loa Loa (eye worm) hypothetical protein 0.0029 0.0078 0.0673
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0118 0.0754
Trichomonas vaginalis tubulin beta chain, putative 0.0273 0.1 1
Echinococcus granulosus alpha tubulin 0.0273 0.1 0.6655
Brugia malayi tubulin alpha-2 chain 0.0273 0.1 0.1378
Schistosoma mansoni multidrug resistance protein 0.0011 0.0007 0.0018
Brugia malayi Telomerase reverse transcriptase 0.1923 0.726 1
Brugia malayi hypothetical protein 0.0011 0.0008 0.0011
Entamoeba histolytica hypothetical protein 0.0024 0.0057 0.0524
Brugia malayi Tubulin gamma chain 0.0147 0.0523 0.0721
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.1125 0.4145
Schistosoma mansoni tyrosinase precursor 0.009 0.0308 0.2025
Brugia malayi ABC transporter family protein 0.0011 0.0007 0.001
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0005 0.0006
Schistosoma mansoni multidrug resistance protein 0.0011 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0273 0.1 0.8717
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Echinococcus granulosus Tubulin beta 2C chain 0.0147 0.0523 0.348
Chlamydia trachomatis protoporphyrinogen oxidase 0.0042 0.0125 0.1036
Schistosoma mansoni topbp1 0.0011 0.0008 0.0025
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0105 0.0699
Schistosoma mansoni amine oxidase 0.0042 0.0125 0.0801
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0043 0.0131 0.0468
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.013 0.0464
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0008 0.0014
Leishmania major alpha tubulin 0.0273 0.1 0.3684
Schistosoma mansoni patched 1 0.0047 0.0144 0.0929
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0147 0.0523 0.1919
Echinococcus multilocularis tubulin alpha 3 chain 0.0273 0.1 0.1546
Giardia lamblia Epsilon tubulin 0.0064 0.0209 0.0758
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0518 0.08
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0008 0.0011
Echinococcus multilocularis Tubulin alpha 1 chain 0.0273 0.1 0.1546
Plasmodium vivax tubulin epsilon chain, putative 0.0147 0.0523 0.1919
Mycobacterium tuberculosis Cell division protein FtsZ 0.0064 0.0209 0.0988
Trypanosoma brucei beta tubulin 0.0147 0.0523 0.1919
Schistosoma mansoni tar DNA-binding protein 0.007 0.0234 0.153
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.0518 0.4508
Entamoeba histolytica P-glycoprotein 5, putative 0.0011 0.0007 0.0026
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0011 0.0007 0.001
Trypanosoma brucei epsilon tubulin 0.0147 0.0523 0.1919
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0109 0.0379 0.3759
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.031 0.1141 0.4203
Entamoeba histolytica tubulin alpha chain, putative 0.0273 0.1 1
Onchocerca volvulus 0.0083 0.0282 0.0275
Schistosoma mansoni niemann-pick C1 (NPC1) 0.011 0.0385 0.2541
Echinococcus multilocularis tubulin subunit TubB 0.0273 0.1 0.1546
Echinococcus multilocularis Tubulin beta 2C chain 0.0147 0.0523 0.0808
Entamoeba histolytica Ran family GTPase 0.0021 0.0048 0.0441
Trichomonas vaginalis tubulin alpha chain, putative 0.0147 0.0523 0.5196
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0068
Schistosoma mansoni transient receptor potential channel 0.0065 0.0213 0.1393
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0574
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.0553 0.0762
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0078 0.0119
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.1125 0.4145
Plasmodium vivax tubulin alpha chain, putative 0.0273 0.1 0.3684
Echinococcus multilocularis Tubulin beta 2C chain 0.0147 0.0523 0.0808
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0119 0.1155
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0008 0.0011
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0119 0.1155
Loa Loa (eye worm) tubulin beta chain 0.0147 0.0523 0.4557
Trypanosoma cruzi epsilon tubulin, putative 0.0147 0.0523 0.1919
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0068
Leishmania major gamma-tubulin 0.0147 0.0523 0.1919
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0171 0.0617
Schistosoma mansoni ran 0.0021 0.0048 0.0293
Schistosoma mansoni hypothetical protein 0.0011 0.001 0.0039
Echinococcus multilocularis peroxisome assembly protein 26 0.0273 0.1 0.1546
Onchocerca volvulus 0.009 0.0308 0.0301
Schistosoma mansoni cpg binding protein 0.003 0.0081 0.0511
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0105 0.0162
Echinococcus multilocularis tubulin beta 1 chain 0.0147 0.0523 0.0808
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0068
Loa Loa (eye worm) tubulin beta-1 chain 0.0147 0.0523 0.4557
Schistosoma mansoni alpha tubulin 0.0273 0.1 0.6646
Schistosoma mansoni tar DNA-binding protein 0.007 0.0234 0.153
Brugia malayi Tubulin alpha-2 chain 0.0273 0.1 0.1378
Trichomonas vaginalis tubulin alpha chain, putative 0.0083 0.0282 0.2765
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0118 0.0181
Echinococcus granulosus tubulin alpha 1C chain 0.0273 0.1 0.6655
Trypanosoma cruzi tubulin delta chain 0.0064 0.0209 0.0755
Leishmania major beta tubulin 0.0147 0.0523 0.1919
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0064 0.0219
Trypanosoma brucei beta tubulin 0.0147 0.0523 0.1919
Mycobacterium ulcerans cell division protein FtsZ 0.0064 0.0209 0.0928
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0153 0.021
Trypanosoma brucei alpha tubulin 0.0273 0.1 0.3684
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0066 0.2895
Schistosoma mansoni hypothetical protein 0.0311 0.1147 0.7629
Schistosoma mansoni hypothetical protein 0.0045 0.0137 0.0887
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0057 0.0499
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0234 0.0322
Echinococcus multilocularis protoporphyrinogen oxidase 0.0042 0.0125 0.0192
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0066 0.062
Loa Loa (eye worm) hypothetical protein 0.0109 0.0379 0.3299
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.031 0.1141 1
Brugia malayi TAR-binding protein 0.007 0.0234 0.0322
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0515 0.1889
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0209 0.2028
Loa Loa (eye worm) tubulin alpha-2 chain 0.0273 0.1 0.8717
Echinococcus granulosus tar DNA binding protein 0.007 0.0234 0.1553
Schistosoma mansoni tyrosinase precursor 0.009 0.0308 0.2025
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0042 0.0125 0.5807
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0007 0.0045
Plasmodium falciparum tubulin beta chain 0.0147 0.0523 0.1919
Trypanosoma cruzi zeta tubulin, putative 0.0064 0.0209 0.0755
Schistosoma mansoni alpha tubulin 0.0273 0.1 0.6646
Plasmodium vivax tubulin alpha chain, putative 0.0273 0.1 0.3684
Plasmodium vivax tubulin beta chain, putative 0.0147 0.0523 0.1919
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.0308 0.268
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.0916
Echinococcus granulosus tubulin alpha 3 chain 0.0273 0.1 0.6655
Echinococcus multilocularis tubulin epsilon chain 0.0147 0.0523 0.0808
Echinococcus granulosus dnaJ subfamily B 0.0405 0.1503 1
Loa Loa (eye worm) tubulin alpha chain 0.0273 0.1 0.8717
Brugia malayi hypothetical protein 0.0042 0.0125 0.0172
Trichomonas vaginalis tubulin gamma chain, putative 0.0147 0.0523 0.5196
Brugia malayi hypothetical protein 0.0011 0.0008 0.0011
Echinococcus granulosus peroxisome assembly protein 26 0.0273 0.1 0.6655
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.031 0.1141 0.556
Brugia malayi Common central domain of tyrosinase family protein 0.009 0.0308 0.0424
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0518 0.3442
Loa Loa (eye worm) hypothetical protein 0.0049 0.0153 0.1326
Echinococcus granulosus tubulin alpha chain 0.0273 0.1 0.6655
Trypanosoma cruzi beta tubulin, putative 0.0147 0.0523 0.1919
Schistosoma mansoni hypothetical protein 0.0106 0.0368 0.2425
Trypanosoma brucei epsilon tubulin 0.0147 0.0523 0.1919
Trypanosoma brucei alpha tubulin 0.0273 0.1 0.3684
Plasmodium falciparum tubulin gamma chain 0.0147 0.0523 0.1919
Plasmodium falciparum multidrug resistance protein 1 0.0011 0.0007 0.001
Leishmania major UDP-galactopyranose mutase 0.0042 0.0125 0.0444
Echinococcus granulosus lysine specific histone demethylase 1A 0.0042 0.0125 0.0826
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.013 0.0464
Leishmania major epsilon tubulin, putative 0.0147 0.0523 0.1919
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0213 0.1417
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0048 0.0074
Entamoeba histolytica hypothetical protein 0.004 0.0118 0.1135
Echinococcus granulosus tubulin alpha 1C chain 0.0273 0.1 0.6655
Loa Loa (eye worm) hypothetical protein 0.0098 0.0339 0.2954
Trypanosoma brucei alpha tubulin 0.0273 0.1 0.3684
Plasmodium vivax delta tubulin, putative 0.0064 0.0209 0.0755
Mycobacterium ulcerans hypothetical protein 0.0026 0.0066 0.0281
Onchocerca volvulus 0.009 0.0308 0.0301
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0008 0.0014

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.02 uM Cytotoxicity against FLT3-dependent human MV4-11 cells after 72 hrs by MTT assay ChEMBL. 22452518

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 22452518

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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