Detailed information for compound 165715

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 453.016 | Formula: C27H33ClN2O2
  • H donors: 1 H acceptors: 2 LogP: 6.39 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@H]([C@H](NC(=O)[C@@H]1CCCCN1CC(=O)c1ccc(cc1)Cl)/C=C/c1ccccc1)C
  • InChi: 1S/C27H33ClN2O2/c1-3-20(2)24(17-12-21-9-5-4-6-10-21)29-27(32)25-11-7-8-18-30(25)19-26(31)22-13-15-23(28)16-14-22/h4-6,9-10,12-17,20,24-25H,3,7-8,11,18-19H2,1-2H3,(H,29,32)/b17-12+/t20-,24+,25-/m0/s1
  • InChiKey: SMPHARQWJLJFBD-ONVFUIMQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin K Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0135 0.0104
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.1832 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0252 0.0327
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.039 0.0718
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3855 0.7221
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0713 0.3548
Brugia malayi MH2 domain containing protein 0.0017 0.0124 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0252 0.0981
Schistosoma mansoni RNA binding protein 0.0147 0.1823 0.3355
Brugia malayi Cytochrome P450 family protein 0.0054 0.0603 0.1136
Leishmania major hypothetical protein, conserved 0.0147 0.1823 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0147 0.1823 0.3435
Onchocerca volvulus 0.0018 0.0135 0.0255
Brugia malayi Smad1 0.0017 0.0124 0.0234
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0147 0.1823 0.3334
Schistosoma mansoni hypothetical protein 0.0032 0.0324 0.0596
Loa Loa (eye worm) Smad1 0.0017 0.0124 0.0234
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.039 0.0592
Echinococcus granulosus cathepsin L cysteine protease 0.0014 0.0081 0.0081
Leishmania major cathepsin L-like protease 0.0027 0.0252 0.0871
Schistosoma mansoni cellular tumor antigen P53 0.0113 0.1378 0.2535
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0147 0.1823 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.0252 0.0453
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0147 0.1823 0.1823
Leishmania major hypothetical protein, conserved 0.0147 0.1823 1
Brugia malayi Papain family cysteine protease containing protein 0.0014 0.0081 0.0152
Echinococcus multilocularis 0.0015 0.0102 0.0102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0252 0.0981
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0603 0.1136
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.039 0.0735
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0102 0.0476
Echinococcus multilocularis SWI:SNF matrix associated 0.0414 0.5307 0.5307
Schistosoma mansoni cytochrome P450 0.0015 0.0102 0.0187
Leishmania major hypothetical protein, conserved 0.0147 0.1823 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0252 0.0327
Brugia malayi cytochrome P450 0.0015 0.0102 0.0192
Trypanosoma cruzi cysteine protease, putative 0.0014 0.0081 0.036
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.003
Plasmodium vivax hypothetical protein, conserved 0.0414 0.5307 1
Onchocerca volvulus 0.0113 0.1378 0.2596
Brugia malayi Cathepsin L-like precursor 0.0027 0.0252 0.0474
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0414 0.5307 1
Brugia malayi MH1 domain containing protein 0.001 0.0024 0.0045
Echinococcus multilocularis cysteine protease 0.0027 0.0252 0.0252
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0252 0.1305
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0603 0.1136
Schistosoma mansoni smad1 5 8 and 0.0017 0.0124 0.0229
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0135 0.0144
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0124 0.0234
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.039 0.0592
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0124 0.0124
Toxoplasma gondii ran binding protein 0.0147 0.1823 0.3307
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0027 0.0252 0.0327
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0147 0.1823 1
Onchocerca volvulus 0.0038 0.039 0.0735
Chlamydia trachomatis SWIB complex protein 0.0414 0.5307 0.5
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0414 0.5307 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0102 0.0192
Loa Loa (eye worm) hypothetical protein 0.0038 0.039 0.0735
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.039 0.0592
Brugia malayi Cathepsin L-like precursor 0.0027 0.0252 0.0474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0252 0.0327
Echinococcus granulosus cathepsin L 0.0014 0.0081 0.0081
Echinococcus multilocularis smad 0.0017 0.0124 0.0124
Brugia malayi beta-lactamase 0.0038 0.039 0.0735
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0027 0.0252 0.0327
Onchocerca volvulus 0.0147 0.1823 0.3435
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0252 0.1305
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0018 0.0135 0.0661
Plasmodium vivax vivapain-2 0.0027 0.0252 0.0446
Loa Loa (eye worm) ctsf protein 0.0027 0.0252 0.0474
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0102 0.0476
Brugia malayi Cathepsin L-like precursor 0.0018 0.0135 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0252 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0252 0.0327
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.039 0.0983
Trypanosoma cruzi cysteine proteinase, putative 0.0014 0.0081 0.036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0252 0.0327
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.039 0.0592
Loa Loa (eye worm) hypothetical protein 0.0032 0.0324 0.0611
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.1242 0.234
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0147 0.1823 0.3435
Schistosoma mansoni hypothetical protein 0.0414 0.5307 0.9765
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0636 0.1026
Loa Loa (eye worm) hypothetical protein 0.0038 0.039 0.0735
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0102 0.012
Echinococcus granulosus cpg binding protein 0.0031 0.031 0.031
Leishmania major cathepsin L-like protease 0.0027 0.0252 0.0871
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 0.0252 0.0474
Leishmania major hypothetical protein, conserved 0.0147 0.1823 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0252 0.0327
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0713 0.0713
Loa Loa (eye worm) transcription factor SMAD2 0.0253 0.3202 0.6033
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0713 0.0713
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0147 0.1823 0.1823
Brugia malayi MH2 domain containing protein 0.0017 0.0124 0.0234
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0045
Leishmania major cathepsin L-like protease 0.0027 0.0252 0.0871
Loa Loa (eye worm) hypothetical protein 0.0147 0.1823 0.3435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0252 0.0981
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0147 0.1823 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0102 0.0476
Schistosoma mansoni hypothetical protein 0.007 0.0817 0.1503
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0014 0.0081 0.036
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.002 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0252 0.0327
Echinococcus multilocularis ring and YY1 binding protein 0.0147 0.1823 0.1823
Schistosoma mansoni fusion 0.0147 0.1823 0.3355
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.0252 0.1305
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0324 0.0611
Loa Loa (eye worm) hypothetical protein 0.0038 0.039 0.0735
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.039 0.0983
Brugia malayi beta-lactamase family protein 0.0038 0.039 0.0735
Loa Loa (eye worm) beta-lactamase 0.0038 0.039 0.0735
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0252 0.0252
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.1823 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.003
Echinococcus multilocularis cysteine protease 0.0027 0.0252 0.0252
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0252 0.0327
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0147 0.1823 1
Echinococcus granulosus SWI:SNF matrix associated 0.0414 0.5307 0.5307
Giardia lamblia Fructose-bisphosphate aldolase 0.0303 0.3855 0.5
Brugia malayi cathepsin L-like precursor 0.0018 0.0135 0.0255
Schistosoma mansoni cpg binding protein 0.003 0.0288 0.053
Brugia malayi MH1 domain containing protein 0.001 0.0024 0.0045
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0252 0.0474
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0147 0.1823 0.3307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0252 0.0327
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.039 0.0983
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.1242 0.234
Plasmodium vivax vivapain-1 0.0014 0.0081 0.0123
Schistosoma mansoni hypothetical protein 0.0414 0.5307 0.9765
Schistosoma mansoni Smad4 0.0017 0.0124 0.0229
Onchocerca volvulus 0.0027 0.0252 0.0474
Schistosoma mansoni hypothetical protein 0.0032 0.0324 0.0596
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3855 0.7221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0252 0.0981
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0713 0.2083
Mycobacterium ulcerans hypothetical protein 0.0038 0.039 0.1667
Onchocerca volvulus 0.0027 0.0252 0.0474
Leishmania major cysteine peptidase A (CPA) 0.0027 0.0252 0.0871
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0252 0.0981
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0135 0.0104
Brugia malayi CXXC zinc finger family protein 0.003 0.0288 0.0543
Leishmania major cathepsin L-like protease 0.0027 0.0252 0.0871
Trypanosoma cruzi WLM domain containing protein, putative 0.0147 0.1823 1
Echinococcus granulosus Zinc finger RanBP2 type 0.0147 0.1823 0.1823
Trypanosoma cruzi cysteine peptidase, putative 0.0014 0.0081 0.036
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.039 0.0592
Loa Loa (eye worm) brahma associated protein 0.0414 0.5307 1
Mycobacterium ulcerans beta-lactamase 0.0038 0.039 0.1667
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0255
Brugia malayi Cathepsin L-like precursor 0.0018 0.0135 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0252 0.0327
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0124 0.0229
Leishmania major cathepsin L-like protease 0.0027 0.0252 0.0871
Brugia malayi Cathepsin L-like precursor 0.0027 0.0252 0.0474
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0252 0.0981
Brugia malayi Cytochrome P450 family protein 0.0054 0.0603 0.1136
Echinococcus multilocularis cpg binding protein 0.0031 0.031 0.031
Schistosoma mansoni TRABID protein (C64 family) 0.0147 0.1823 0.3355
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3855 0.7221
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0724 0.1332
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.5435 0.5435
Brugia malayi brahma associated protein 60 kDa 0.0414 0.5307 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0252 0.0474
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.1832 1
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0147 0.1823 1
Schistosoma mansoni zinc finger protein 0.0147 0.1823 0.3355
Onchocerca volvulus 0.0027 0.0252 0.0474
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0252 0.1305
Loa Loa (eye worm) fibroinase 0.0027 0.0252 0.0474
Trichomonas vaginalis esterase, putative 0.0038 0.039 0.0592
Echinococcus multilocularis Smad4 0.0017 0.0124 0.0124
Schistosoma mansoni cathepsin s 0.0009 0.0016 0.0029
Loa Loa (eye worm) cysteine protease 0.0027 0.0252 0.0474
Loa Loa (eye worm) hypothetical protein 0.0147 0.1823 0.3435
Plasmodium vivax hypothetical protein, conserved 0.0038 0.039 0.0707
Echinococcus multilocularis SWI:SNF matrix associated 0.0414 0.5307 0.5307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0252 0.0327
Brugia malayi Cathepsin L-like precursor 0.0027 0.0252 0.0474
Brugia malayi Cytochrome P450 family protein 0.0015 0.0102 0.0192
Echinococcus multilocularis zinc finger protein Ran binding 0.0147 0.1823 0.1823
Loa Loa (eye worm) hypothetical protein 0.0147 0.1823 0.3435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0252 0.0327
Echinococcus granulosus cysteine protease 0.0014 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0147 0.1823 0.3435
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0252 0.0252
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0009 0.0016 0.003
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0124 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.1823 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0252 0.0981
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0124 0.0124
Brugia malayi SWIB/MDM2 domain containing protein 0.0414 0.5307 1
Trichomonas vaginalis conserved hypothetical protein 0.0414 0.5307 1
Trypanosoma cruzi cysteine proteinase, putative 0.0014 0.0081 0.036
Brugia malayi cathepsin F-like cysteine proteinase 0.0009 0.0016 0.003
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0324 0.0611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0252 0.0327
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.1832 0.5898
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0252 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0252 0.0327
Plasmodium vivax unspecified product 0.0014 0.0081 0.0123
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0324 0.0324
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0817 0.1539
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.1242 0.234
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0252 0.0327
Brugia malayi Cathepsin L-like precursor 0.0027 0.0252 0.0474
Brugia malayi MH1 domain containing protein 0.0017 0.0124 0.0234
Mycobacterium leprae conserved hypothetical protein 0.0038 0.039 0.1667
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3855 0.7221
Trypanosoma cruzi cytochrome P450, putative 0.0054 0.0603 0.3249
Onchocerca volvulus 0.0027 0.0252 0.0474
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3855 0.7221
Schistosoma mansoni cpg binding protein 0.0031 0.031 0.0571
Echinococcus granulosus cathepsin l1 0.0027 0.0252 0.0252
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3855 0.7221
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.039 0.0983
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0147 0.1823 0.3435
Brugia malayi beta-lactamase family protein 0.0038 0.039 0.0735
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0014 0.0081 0.0149
Brugia malayi Cathepsin L-like precursor 0.0027 0.0252 0.0474
Mycobacterium tuberculosis Conserved protein 0.0038 0.039 0.0983
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0014 0.0081 0.0149
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.039 0.0735
Leishmania major cathepsin L-like protease 0.0027 0.0252 0.0871
Loa Loa (eye worm) hypothetical protein 0.0038 0.0401 0.0755
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0414 0.5307 1
Onchocerca volvulus 0.0147 0.1823 0.3435
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0147 0.1823 1
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0713 0.1173
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.3855 1
Brugia malayi Cathepsin L-like precursor 0.0009 0.0016 0.003
Leishmania major hypothetical protein, conserved 0.0147 0.1823 1
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0252 0.0463
Loa Loa (eye worm) hypothetical protein 0.0027 0.0252 0.0474
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0713 0.1311
Brugia malayi MH2 domain containing protein 0.0253 0.3202 0.6033
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.039 0.0983
Loa Loa (eye worm) histone methyltransferase 0.0009 0.002 0.0037
Loa Loa (eye worm) hypothetical protein 0.0038 0.039 0.0735
Leishmania major cathepsin L-like protease 0.0027 0.0252 0.0871
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0324 0.0611
Onchocerca volvulus 0.0038 0.039 0.0735
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0252 0.0453
Onchocerca volvulus 0.0038 0.039 0.0735
Schistosoma mansoni smad1 5 8 and 0.0017 0.0124 0.0229
Chlamydia trachomatis DNA topoisomerase I 0.0414 0.5307 0.5
Schistosoma mansoni hypothetical protein 0.0414 0.5307 0.9765
Trypanosoma brucei hypothetical protein, conserved 0.0147 0.1823 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0255
Echinococcus multilocularis cathepsin L 0.0014 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0032 0.0324 0.0596
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.039 0.2071
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0018 0.0034
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.0252 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0252 0.0327
Brugia malayi Papain family cysteine protease containing protein 0.0014 0.0081 0.0152
Echinococcus granulosus GPCR family 2 0.0032 0.0324 0.0324
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0414 0.5307 0.5307
Mycobacterium ulcerans lipase LipD 0.0038 0.039 0.1667
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.039 0.1667
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0147 0.1823 0.1823
Mycobacterium tuberculosis Conserved protein 0.0038 0.039 0.0983
Onchocerca volvulus 0.003 0.0288 0.0543
Schistosoma mansoni smad1 5 8 and 0.0017 0.0124 0.0229
Onchocerca volvulus 0.0147 0.1823 0.3435
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0414 0.5307 0.5307
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0324 0.0324
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0147 0.1823 0.3435
Loa Loa (eye worm) hypothetical protein 0.0147 0.1823 0.3435
Brugia malayi Cathepsin L-like cysteine proteinase 0.0018 0.0135 0.0255
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0252 0.0327
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.039 0.2071
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0324 0.0324
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0252 0.0463
Echinococcus granulosus dnaJ subfamily B 0.0424 0.5435 0.5435
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0324 0.0324
Schistosoma mansoni brg-1 associated factor 0.0414 0.5307 0.9765
Schistosoma mansoni cpg binding protein 0.0031 0.031 0.0571
Echinococcus multilocularis SWI:SNF matrix associated 0.0414 0.5307 0.5307
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.039 0.1667
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0252 0.0453
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0252 0.1305
Onchocerca volvulus 0.0027 0.0252 0.0474
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.039 0.039
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0038 0.039 0.0735
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0713 0.3531
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.3855 1
Toxoplasma gondii cathepsin CPL 0.0027 0.0252 0.0288
Trypanosoma brucei hypothetical protein, conserved 0.0147 0.1823 1
Onchocerca volvulus 0.0414 0.5307 1
Loa Loa (eye worm) nuclear factor I 0.001 0.0024 0.0045
Onchocerca volvulus 0.0027 0.0252 0.0474
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0252 0.0252
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.039 0.0983
Echinococcus granulosus ring and YY1 binding protein 0.0147 0.1823 0.1823
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3855 0.7221
Loa Loa (eye worm) MH2 domain-containing protein 0.0253 0.3202 0.6033
Echinococcus granulosus smad 0.0017 0.0124 0.0124
Echinococcus granulosus Smad4 0.0017 0.0124 0.0124
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0414 0.5307 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0054 0.0603 0.2897
Schistosoma mansoni smad 0.0017 0.0124 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0252 0.0981
Loa Loa (eye worm) hypothetical protein 0.0113 0.1378 0.2596
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.3035 1
Mycobacterium leprae Probable lipase LipE 0.0038 0.039 0.1667
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0014 0.0081 0.0149
Brugia malayi Cytochrome P450 family protein 0.0015 0.0102 0.0192
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0713 0.1311
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0102 0.0102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0252 0.0327
Onchocerca volvulus 0.0147 0.1823 0.3435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0252 0.0981
Echinococcus multilocularis GPCR, family 2 0.0032 0.0324 0.0324
Leishmania major cathepsin L-like protease 0.0027 0.0252 0.0871
Trypanosoma cruzi WLM domain containing protein, putative 0.0147 0.1823 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0817 0.1539
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0713 0.3531
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0252 0.0474
Echinococcus multilocularis tumor protein p63 0.0773 1 1
Loa Loa (eye worm) CYP4Cod1 0.0054 0.0603 0.1136
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.039 0.0718
Loa Loa (eye worm) hypothetical protein 0.0038 0.039 0.0735
Trypanosoma brucei cytochrome P450, putative 0.0054 0.0603 0.2997
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0252 0.0252
Plasmodium vivax vivapain-3 0.0014 0.0081 0.0123
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0713 0.3531
Brugia malayi YY1-associated factor 2 0.0147 0.1823 0.3435
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0124 0.0234
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0414 0.5307 1
Schistosoma mansoni hypothetical protein 0.0032 0.0324 0.0596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0252 0.0327
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0252 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0252 0.0327
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0252 0.0981
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0135 0.0249
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.0252 0.0252
Echinococcus granulosus cathepsin l1 0.0018 0.0135 0.0135
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0147 0.1823 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0009 0.0016 0.003
Plasmodium falciparum cysteine proteinase falcipain 3 0.0027 0.0252 0.0327
Leishmania major hypothetical protein, conserved 0.0038 0.039 0.1675
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0252 0.0981
Loa Loa (eye worm) hypothetical protein 0.0103 0.1242 0.234
Schistosoma mansoni hypothetical protein 0.0015 0.0102 0.0187
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0124 0.0124
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.039 0.0983
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3855 0.7221
Echinococcus granulosus zinc finger protein Ran binding 0.0147 0.1823 0.1823
Treponema pallidum fructose-bisphosphate aldolase 0.0303 0.3855 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.039 0.1775
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.1823 1
Loa Loa (eye worm) cytochrome P450 0.0015 0.0102 0.0192
Onchocerca volvulus 0.0027 0.0252 0.0474
Toxoplasma gondii ABC1 family protein 0.0038 0.039 0.0554
Onchocerca volvulus Cathepsin F homolog 0.0027 0.0252 0.0474
Brugia malayi MH1 domain containing protein 0.0017 0.0124 0.0234
Mycobacterium tuberculosis Conserved protein 0.0038 0.039 0.0983
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0414 0.5307 1
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0252 0.0474
Plasmodium vivax vivapain-2 0.0027 0.0252 0.0446
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0255
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0288 0.0543
Schistosoma mansoni hypothetical protein 0.0424 0.5435 1
Brugia malayi brahma associated protein 60 kDa 0.0414 0.5307 1
Schistosoma mansoni hypothetical protein 0.0147 0.1823 0.3355
Trypanosoma cruzi cytochrome P450, putative 0.0054 0.0603 0.3249
Leishmania major cytochrome p450-like protein 0.0054 0.0603 0.2912
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0147 0.1823 0.3435
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0252 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0252 0.0327

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.28 uM Inhibitory activity against cathepsin K ChEMBL. 11677133
IC50 (binding) = 0.28 uM Inhibitory activity against cathepsin K ChEMBL. 11677133

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.