Detailed information for compound 1658456

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.472 | Formula: C21H30F2N2O2
  • H donors: 0 H acceptors: 1 LogP: 4.12 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H]1CCCN1CCCOc1ccc(cc1)C(=O)CN1CCC(CC1)(F)F
  • InChi: 1S/C21H30F2N2O2/c1-17-4-2-11-25(17)12-3-15-27-19-7-5-18(6-8-19)20(26)16-24-13-9-21(22,23)10-14-24/h5-8,17H,2-4,9-16H2,1H3/t17-/m1/s1
  • InChiKey: FYNKTKAUIWKPFC-QGZVFWFLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H3 Starlite/ChEMBL References
Rattus norvegicus Histamine H3 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus biogenic amine 5HT receptor Histamine H3 receptor   445 aa 405 aa 25.2 %
Loa Loa (eye worm) hypothetical protein Histamine H3 receptor   445 aa 384 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0325 0.101
Brugia malayi glutathione reductase 0.0048 0.0358 0.0357
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0848 0.0847
Brugia malayi Cathepsin L-like precursor 0.0011 0.0008 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0139 0.281
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0139 0.281
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0383 0.1192
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0067 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0504 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0251 0.0251
Echinococcus multilocularis cysteine protease 0.0017 0.0061 0.0061
Echinococcus granulosus CD36 class B scavenger receptor 0.1061 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0061 0.1211
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0504 1
Echinococcus multilocularis lamin 0.0054 0.0419 0.0419
Trypanosoma cruzi ISWI complex protein 0.0015 0.0047 0.0913
Schistosoma mansoni zinc finger protein 0.0019 0.0087 0.0086
Brugia malayi Thioredoxin reductase 0.0048 0.0358 0.0357
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0942 0.8844
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0942 0.8903
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0061 0.1211
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0494 1
Trypanosoma cruzi ISWI complex protein 0.0015 0.0047 0.0913
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.0901 0.09
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0383 0.1192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0186
Echinococcus granulosus lamin dm0 0.0054 0.0419 0.0419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0504 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0061 0.006
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.008 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.006
Schistosoma mansoni sodium/solute symporter 0.0039 0.0272 0.0271
Echinococcus granulosus expressed protein 0.0017 0.0067 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0008 0.0023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0055 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0504 1
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0061 0.0186
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0942 0.8844
Echinococcus multilocularis high affinity choline transporter 1 0.0352 0.3253 0.3253
Schistosoma mansoni hypothetical protein 0.0043 0.0309 0.0308
Echinococcus multilocularis lysosome membrane protein 2 0.1061 1 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0139 0.0842
Schistosoma mansoni hypothetical protein 0.002 0.0097 0.0096
Loa Loa (eye worm) hypothetical protein 0.0038 0.0264 0.0263
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.1058 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0139 0.0842
Loa Loa (eye worm) hypothetical protein 0.0352 0.3253 0.3252
Loa Loa (eye worm) hypothetical protein 0.0025 0.0139 0.0138
Onchocerca volvulus 0.0017 0.0061 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0186
Echinococcus granulosus CD36 class B scavenger receptor 0.1061 1 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0886 0.0885
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0008 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0404 1
Trypanosoma brucei ISWI complex protein 0.0015 0.0047 0.0913
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0186
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0061 0.0298
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0063 0.0062
Plasmodium falciparum glutathione reductase 0.0017 0.0061 0.1478
Schistosoma mansoni hypothetical protein 0.0043 0.0309 0.0308
Leishmania major cathepsin L-like protease 0.0063 0.0504 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0063 0.0062
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0067 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0061 0.1185
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0039 0.0272 0.0272
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0039 0.0272 0.0271
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.1058 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0061 0.1185
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0358 0.7105
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0444 0.3872
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0419 0.0418
Schistosoma mansoni lamin 0.0054 0.0419 0.0418
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0055 0.0054
Loa Loa (eye worm) hypothetical protein 0.0031 0.0202 0.0201
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0251 0.4471
Schistosoma mansoni patched 1 0.0044 0.0325 0.0324
Brugia malayi cathepsin L-like precursor 0.0011 0.0008 0.0007
Echinococcus granulosus GPCR family 2 0.0031 0.0202 0.0202
Echinococcus granulosus intermediate filament protein 0.0054 0.0419 0.0419
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0504 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0325 0.0324
Echinococcus granulosus zinc finger protein 0.0019 0.0087 0.0087
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0494 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0139 0.281
Brugia malayi Cathepsin L-like precursor 0.0011 0.0008 0.0007
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0055 0.1073
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0024 0.0128 0.0127
Schistosoma mansoni lamin 0.0054 0.0419 0.0418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0008 0.0023
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0504 1
Schistosoma mansoni hypothetical protein 0.0336 0.3099 0.3099
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0152 0.0152
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0067 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0055 0.0054
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0055 0.1073
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0251 0.4975
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0061 0.1478
Leishmania major cathepsin L-like protease 0.0017 0.0061 0.0298
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0001 0.00000027759
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0383 0.7352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0504 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0251 0.2829
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0063 0.0063
Schistosoma mansoni inositol transporter 0.0039 0.0272 0.0271
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0251 0.025
Plasmodium vivax glutathione reductase, putative 0.0048 0.0358 0.8862
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0186
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0055 0.0055
Echinococcus multilocularis neuropeptide s receptor 0.0474 0.4415 0.4415
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0061 0.1185
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0383 0.7594
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0061 0.1561
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0848 0.0847
Echinococcus granulosus lamin 0.0054 0.0419 0.0419
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0251 0.025
Brugia malayi Cathepsin L-like precursor 0.0017 0.0061 0.006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0061 0.1185
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0325 0.0325
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0007
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0383 0.7352
Leishmania major cathepsin L-like protease 0.0063 0.0504 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0061 0.1211
Schistosoma mansoni ferritin 0.0017 0.0067 0.0066
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0008 0.0083
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0851 0.7999 0.7999
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0061 0.0673
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0061 0.9047
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0358 0.0358
Trypanosoma brucei trypanothione reductase 0.0048 0.0358 0.7105
Onchocerca volvulus 0.0017 0.0061 0.006
Onchocerca volvulus 0.0054 0.0419 0.0418
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0466 0.0466
Brugia malayi Bromodomain containing protein 0.0038 0.0264 0.0263
Echinococcus granulosus high affinity choline transporter 1 0.0352 0.3253 0.3253
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0504 1
Schistosoma mansoni hypothetical protein 0.0074 0.0608 0.0607
Brugia malayi MH2 domain containing protein 0.0116 0.1004 0.1003
Brugia malayi GH02984p 0.0352 0.3253 0.3252
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0061 0.03
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0444 0.8675
Onchocerca volvulus 0.0025 0.0139 0.0138
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0055 0.1073
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0251 0.0781
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1004 0.1003
Plasmodium falciparum thioredoxin reductase 0.0017 0.0061 0.1478
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.007 0.0149
Leishmania major cathepsin L-like protease 0.0017 0.0061 0.0298
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0061 0.1185
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0251 0.0251
Mycobacterium ulcerans hypothetical protein 0.0025 0.0139 0.281
Brugia malayi PHD-finger family protein 0.0025 0.0138 0.0137
Schistosoma mansoni hypothetical protein 0.0068 0.0549 0.0548
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0055 0.0054
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0115 0.0115
Plasmodium vivax vivapain-2 0.0017 0.0061 0.1476
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0139 0.2023
Echinococcus granulosus cathepsin l1 0.0011 0.0008 0.0008
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0358 0.8862
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0061 0.0673
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0186
Echinococcus multilocularis ferritin 0.0017 0.0067 0.0067
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0325 0.0325
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0375 0.7442
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0251 0.0781
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0061 0.03
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0055 0.0055
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0241 0.0241
Onchocerca volvulus 0.0017 0.0061 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0186
Echinococcus granulosus cathepsin l1 0.0017 0.0061 0.0061
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0202 0.0201
Plasmodium falciparum thioredoxin reductase 0.0048 0.0358 0.8862
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0452 0.8963
Brugia malayi Cathepsin L-like precursor 0.0017 0.0061 0.006
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0179 0.0178
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0383 0.0383
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0067 0.1338
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0061 0.006
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0357 0.3298 0.3297
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0383 0.0382
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0383 0.1192
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0055 0.1073
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0097 0.0096
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0186
Loa Loa (eye worm) hypothetical protein 0.0042 0.0305 0.0304
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0069 0.0068
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0251 0.025
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0061 0.1476
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0504 1
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0061 0.1184
Echinococcus multilocularis cysteine protease 0.0017 0.0061 0.0061
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.008 0.1595
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0061 0.006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0061 0.1185
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0061 0.0186
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0139 0.281
Brugia malayi hypothetical protein 0.0053 0.0404 0.0403
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0383 0.7594
Brugia malayi hypothetical protein 0.0401 0.3716 0.3716
Brugia malayi CHE-14 protein 0.0044 0.0325 0.0324
Leishmania major cathepsin L-like protease 0.0063 0.0504 1
Onchocerca volvulus 0.0017 0.0061 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0186
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0444 0.8983
Brugia malayi Cathepsin L-like precursor 0.0017 0.0061 0.006
Schistosoma mansoni ferritin 0.0017 0.0067 0.0066
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0039 0.0272 0.0272
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0128 0.0128
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0061 0.006
Echinococcus multilocularis nibrin 0.001 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0186
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0061 0.006
Echinococcus granulosus lysosome membrane protein 2 0.1061 1 1
Loa Loa (eye worm) cysteine protease 0.0017 0.0061 0.006
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0419 0.0418
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0061 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0186
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0061 0.0061
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0404 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0139 0.1565
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0494 0.977
Schistosoma mansoni hypothetical protein 0.0043 0.0309 0.0308
Echinococcus granulosus nibrin 0.001 0.0001 0.0001
Schistosoma mansoni intermediate filament proteins 0.0054 0.0419 0.0418
Entamoeba histolytica cysteine protease, putative 0.0017 0.0061 0.0673
Schistosoma mansoni hypothetical protein 0.0043 0.0309 0.0308
Brugia malayi hypothetical protein 0.0034 0.0227 0.0226
Schistosoma mansoni CD36-like class B scavenger receptor 0.1061 1 1
Schistosoma mansoni hypothetical protein 0.0336 0.3099 0.3099
Loa Loa (eye worm) fibroinase 0.0017 0.0061 0.006
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0079
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0202 0.0201
Loa Loa (eye worm) ctsf protein 0.0017 0.0061 0.006
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0404 0.8017
Leishmania major trypanothione reductase 0.0048 0.0358 0.6814
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0079
Schistosoma mansoni ferritin light chain 0.0017 0.0067 0.0066
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0202 0.0202
Echinococcus multilocularis protein dispatched 1 0.0051 0.0384 0.0384
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0019 0.0018
Entamoeba histolytica hypothetical protein 0.0074 0.0608 0.6856
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0186
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0886 0.0886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0186
Echinococcus multilocularis musashi 0.0054 0.0419 0.0419
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0251 0.6552
Loa Loa (eye worm) hypothetical protein 0.0025 0.0139 0.0138
Brugia malayi hypothetical protein 0.0401 0.3716 0.3716
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0061 0.03
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0061 0.1185
Echinococcus multilocularis lamin dm0 0.0054 0.0419 0.0419
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0061 0.0056
Echinococcus multilocularis Niemann Pick C1 protein 0.0148 0.1308 0.1308
Echinococcus multilocularis zinc finger protein 0.0019 0.0087 0.0087
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0942 0.8844
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0152 0.0152
Leishmania major hypothetical protein, conserved 0.0053 0.0404 0.7818
Loa Loa (eye worm) hypothetical protein 0.0053 0.041 0.0409
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0186
Loa Loa (eye worm) hypothetical protein 0.0026 0.0152 0.0151
Echinococcus granulosus sodium:glucose cotransporter 0.0039 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0099 0.0848 0.0847
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0061 0.1185
Schistosoma mansoni hypothetical protein 0.0031 0.0202 0.0201
Echinococcus granulosus CD36 class B scavenger receptor 0.1061 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0061 0.1478
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1058 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0061 0.1476
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0055 0.1096
Entamoeba histolytica hypothetical protein 0.0074 0.0608 0.6856
Loa Loa (eye worm) hypothetical protein 0.0025 0.0143 0.0142
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0202 0.0202
Echinococcus multilocularis CD36 class B scavenger receptor 0.1061 1 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0251 0.0251
Echinococcus multilocularis solute carrier family 5 0.0039 0.0272 0.0272
Toxoplasma gondii thioredoxin reductase 0.0048 0.0358 0.7257
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0063 0.0063
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0139 0.1309
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0186
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0061 0.9047
Echinococcus granulosus Niemann Pick C1 protein 0.0148 0.1308 0.1308
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0202 0.0201
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0001 0.0000031374
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0186
Echinococcus multilocularis CD36 class B scavenger receptor 0.1061 1 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0055 0.1096
Schistosoma mansoni hypothetical protein 0.0031 0.0202 0.0201
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0494 0.0493
Echinococcus multilocularis CD36 class B scavenger receptor 0.1061 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0061 0.1478
Onchocerca volvulus 0.0017 0.0061 0.006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.007 0.0149
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0139 0.281
Schistosoma mansoni bromodomain containing protein 0.0063 0.0499 0.0498
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0444 0.0444
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0139 0.0138
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0039 0.0272 0.5506
Echinococcus multilocularis protein patched 0.0044 0.0325 0.0325
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0001 0.0000056353
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0061 0.006
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0139 0.1565
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0139 0.1565
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0061 0.0061
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0061 0.006
Leishmania major cathepsin L-like protease 0.0017 0.0061 0.0298
Schistosoma mansoni ferritin light chain 0.0017 0.0067 0.0066
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0061 0.006
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.2212 0.2212
Loa Loa (eye worm) hypothetical protein 0.0357 0.3298 0.3297
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0061 0.1476
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0055 0.0176
Echinococcus granulosus sodium:myo inositol cotransporter 0.0039 0.0272 0.0272
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0055 0.1338
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0444 0.0443
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0494 0.0494
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0504 1
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0504 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0061 0.1185
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0886 0.0885
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0001 0.00000086625
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0067 0.0623
Schistosoma mansoni ferritin 0.0017 0.0067 0.0066
Schistosoma mansoni apoferritin-2 0.0017 0.0067 0.0066
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.1058 1
Echinococcus multilocularis CD36 class B scavenger receptor 0.1061 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0061 0.1185
Loa Loa (eye worm) glutathione reductase 0.0048 0.0358 0.0357
Brugia malayi Cathepsin L-like precursor 0.0017 0.0061 0.006
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0608 0.0608
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0055 0.0054
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0061 0.1185
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0251 0.0251
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0061 0.006
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0407 0.0406
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0143 0.0142
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0494 0.0494
Echinococcus multilocularis GPCR, family 2 0.0031 0.0202 0.0202
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0055 0.0055
Echinococcus granulosus neuropeptide s receptor 0.0474 0.4415 0.4415
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0251 0.0781
Loa Loa (eye worm) hypothetical protein 0.0025 0.0139 0.0138
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0358 0.0358
Schistosoma mansoni hypothetical protein 0.0015 0.0047 0.0046
Onchocerca volvulus 0.0054 0.0419 0.0418
Echinococcus granulosus ferritin 0.0017 0.0067 0.0067
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0039 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0079
Loa Loa (eye worm) hypothetical protein 0.0401 0.3716 0.3716
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0008 0.0007
Echinococcus granulosus sodium:glucose cotransporter 2 0.0039 0.0272 0.0272
Echinococcus multilocularis CD36 class B scavenger receptor 0.1061 1 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0179 0.0178
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0383 0.0382
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0494 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0251 0.4975
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0383 0.7594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0186
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0063 0.0063
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.008 0.1948
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0404 0.8017
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0241 0.0241
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0039 0.0272 0.0272
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0886 0.0886
Echinococcus granulosus geminin 0.0336 0.3099 0.3099
Echinococcus multilocularis expressed conserved protein 0.0097 0.0826 0.0826
Entamoeba histolytica hypothetical protein 0.0074 0.0608 0.6856
Brugia malayi MAP kinase sur-1 0.005 0.0383 0.0382
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0061 0.7588
Schistosoma mansoni CD36-like class B scavenger receptor 0.1061 1 1
Schistosoma mansoni scavenger receptor class B type-2 (sr-B2) 0.1061 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0549 0.0548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0504 1
Brugia malayi intermediate filament protein 0.0054 0.0419 0.0418
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0063 0.0062
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0494 1
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.3205 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0061 0.1478
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0444 0.8983
Schistosoma mansoni zinc finger protein 0.0015 0.0047 0.0046
Plasmodium falciparum glutathione reductase 0.0048 0.0358 0.8862
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0139 0.2023
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0251 0.0251
Echinococcus multilocularis geminin 0.0336 0.3099 0.3099
Echinococcus granulosus solute carrier family 5 0.0039 0.0272 0.0272
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0139 0.0138
Brugia malayi hypothetical protein 0.0074 0.0608 0.0607
Echinococcus granulosus neuropeptide receptor A26 0.0474 0.4415 0.4415
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0115 0.0114
Brugia malayi Bromodomain containing protein 0.0074 0.061 0.0609
Entamoeba histolytica hypothetical protein 0.0074 0.0608 0.6856
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0067 0.1338
Echinococcus granulosus CD36 class B scavenger receptor 0.1061 1 1
Onchocerca volvulus 0.0017 0.0061 0.006
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0139 0.2023
Trypanosoma brucei protein kinase, putative 0.005 0.0383 0.7594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0186
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0404 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0549 0.0548
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0115 0.0115
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0444 0.0443
Schistosoma mansoni hypothetical protein 0.0031 0.0202 0.0201
Loa Loa (eye worm) hypothetical protein 0.0044 0.0325 0.0324
Plasmodium vivax vivapain-2 0.0017 0.0061 0.1476
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.007 0.0149
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.007 0.0569 0.0568
Brugia malayi follicle stimulating hormone receptor 0.0243 0.2212 0.2212
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0037 0.0251 0.025
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0128 0.0128
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0358 0.0357
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0358 0.3025
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0383 0.0383
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0504 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0202 0.0202
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0383 0.1192
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0608 0.0607
Loa Loa (eye worm) hypothetical protein 0.0054 0.0419 0.0418
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.008 0.1948
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0494 0.0493
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.007 0.0149
Trichomonas vaginalis ferritin, putative 0.0017 0.0067 0.0206
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0031 0.0202 0.0201
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0608 0.0608
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0061 0.03
Loa Loa (eye worm) hypothetical protein 0.1061 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0061 0.0186
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0063 0.0062
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0251 0.4975
Leishmania major cathepsin L-like protease 0.0017 0.0061 0.0298
Loa Loa (eye worm) hypothetical protein 0.1061 1 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0419 0.0418
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0007
Mycobacterium tuberculosis Probable reductase 0.0109 0.0942 0.8844
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0404 0.8188
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0886 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0061 0.0061
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0383 1
Schistosoma mansoni apoferritin-2 0.0017 0.0067 0.0066
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0001 0.00000086625
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0383 0.7594
Brugia malayi Cathepsin L-like precursor 0.0017 0.0061 0.006
Schistosoma mansoni ferritin 0.0017 0.0067 0.0066
Echinococcus granulosus replication factor c subunit 1 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0079
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0383 0.7594
Echinococcus granulosus CD36 class B scavenger receptor 0.1061 1 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0055 0.1338
Onchocerca volvulus Lysosome membrane protein 2 homolog 0.1061 1 1
Brugia malayi Sodium:solute symporter family protein 0.0039 0.0272 0.0271
Treponema pallidum NADH oxidase 0.0017 0.0061 0.9047
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0419 0.0418
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0466 0.0466
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0061 0.0061
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0061 0.1211
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0942 0.8844
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0186
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0019 0.0018
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0061 0.0186
Schistosoma mansoni high-affinity choline transporter 0.0352 0.3253 0.3252
Leishmania major cathepsin L-like protease 0.0017 0.0061 0.0298
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0494 0.4371
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0139 0.281
Echinococcus multilocularis neuropeptide receptor A26 0.0474 0.4415 0.4415
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0061 0.0061
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0848 0.0847
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0383 0.7756
Schistosoma mansoni cd36 antigen 0.0401 0.3716 0.3716
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0942 0.8844
Onchocerca volvulus 0.0011 0.0009 0.0008
Echinococcus multilocularis expressed protein 0.0017 0.0067 0.0067
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0061 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0504 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0139 0.0138
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.008 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0061 0.0186
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0061 0.1211
Onchocerca volvulus 0.0017 0.0061 0.006
Onchocerca volvulus 0.0011 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.004 0.0287 0.0286
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0001 0.00000086625
Loa Loa (eye worm) hypothetical protein 0.1061 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0061 0.1185
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0007
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0404 0.8017
Loa Loa (eye worm) hypothetical protein 0.0401 0.3716 0.3716
Echinococcus granulosus expressed conserved protein 0.0097 0.0826 0.0826
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0139 0.1309
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0139 0.281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0061 0.0186
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0401 0.3716 0.3716
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0202 0.0202
Toxoplasma gondii cathepsin CPL 0.0017 0.0061 0.1209
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1004 0.1003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0504 1
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0067 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0061 0.1185
Onchocerca volvulus 0.0039 0.0272 0.0271
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0063 0.0063
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0383 0.0383
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0325 0.0325
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0055 0.0055
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0053 0.0404 0.0403
Schistosoma mansoni inositol transporter 0.0039 0.0272 0.0271

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.8 nM Inverse agonist activity at human histamine H3 receptor by [35S]-GTPgammaS binding assay ChEMBL. 22450133
IC50 (ADMET) > 30 uM Inhibition of CYP1A2 ChEMBL. 22450133
IC50 (ADMET) > 30 uM Inhibition of CYP2C9 ChEMBL. 22450133
IC50 (ADMET) > 30 uM Inhibition of CYP2C19 ChEMBL. 22450133
IC50 (ADMET) > 30 uM Inhibition of CYP2D6 ChEMBL. 22450133
IC50 (ADMET) > 30 uM Inhibition of CYP3A4 ChEMBL. 22450133
Kb (functional) = 3.7 nM Antagonist activity at human histamine H3 receptor assessed as inhibition of [35S]-GTPgammaS binding ChEMBL. 22450133
Ki (binding) = 11 nM Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells ChEMBL. 22450133
Ki (binding) = 43 nM Displacement of [3H]NAMH from rat histamine H3 receptor expressed in CHO cells ChEMBL. 22450133

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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