Detailed information for compound 168692

Basic information

Technical information
  • TDR Targets ID: 168692
  • Name: fluoranthen-3-amine
  • MW: 217.265 | Formula: C16H11N
  • H donors: 1 H acceptors: 0 LogP: 3.82 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc2c3c1cccc3c1c2cccc1
  • InChi: 1S/C16H11N/c17-15-9-8-13-11-5-2-1-4-10(11)12-6-3-7-14(15)16(12)13/h1-9H,17H2
  • InChiKey: VHGJAFIHUSTRGB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-fluoranthenamine
  • fluoranthen-3-ylamine
  • 3-aminofluoranthene
  • 2693-46-1
  • SBB003376
  • 4-12-00-03463 (Beilstein Handbook Reference)
  • BRN 2212365
  • CCRIS 7011
  • EINECS 220-263-7
  • NSC 57469
  • ZINC01841840
  • 4-Aminofluoranthene
  • NSC57469
  • A55403_ALDRICH

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens tumor susceptibility 101 Starlite/ChEMBL No references
Homo sapiens corticotropin releasing hormone receptor 2 No references
Homo sapiens nuclear factor, erythroid 2-like 2 No references
Homo sapiens kelch-like ECH-associated protein 1 No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens corticotropin releasing hormone binding protein No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative Get druggable targets OG5_130760 All targets in OG5_130760
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K10456 kelch-like protein 19, putative Get druggable targets OG5_134673 All targets in OG5_134673
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus kelch ECH associated protein 1 Get druggable targets OG5_134673 All targets in OG5_134673
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis kelch ECH associated protein 1 Get druggable targets OG5_134673 All targets in OG5_134673
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134673 All targets in OG5_134673
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus kelch ECH associated protein 1 like Get druggable targets OG5_134673 All targets in OG5_134673
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130760 All targets in OG5_130760
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis Kelch repeat type 1 Get druggable targets OG5_134673 All targets in OG5_134673
Schistosoma japonicum Kelch-like ECH-associated protein 1, putative Get druggable targets OG5_134673 All targets in OG5_134673
Brugia malayi hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis kelch ECH associated protein 1 Get druggable targets OG5_134673 All targets in OG5_134673
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K01931 tumor suppressor protein 101 [EC:6.3.2.19], putative Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma japonicum IPR001879,Hormone receptor, extracellular,domain-containing Get druggable targets OG5_130760 All targets in OG5_130760
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 Get druggable targets OG5_130760 All targets in OG5_130760
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus kelch ECH associated protein 1 like Get druggable targets OG5_134673 All targets in OG5_134673
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c corticotropin releasing hormone receptor 2 438 aa 383 aa 26.1 %
Brugia malayi Kelch motif family protein kelch-like ECH-associated protein 1 624 aa 565 aa 31.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.0261 0.0253
Schistosoma mansoni kinase 0.0058 0.0152 0.0283
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0009 0.0002
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0009 0.0001
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.1773 0.5356 1
Echinococcus granulosus G protein coupled receptor 139 0.0094 0.0261 0.0253
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0054 0.0515
Plasmodium falciparum transporter, putative 0.0026 0.0054 0.348
Schistosoma mansoni alpha-1 adrenergic receptor 0.0094 0.0261 0.0488
Brugia malayi Glutamate receptor 1 precursor 0.0037 0.0088 0.0149
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0009 0.0017
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0095 0.0263 0.5656
Schistosoma mansoni hypothetical protein 0.0041 0.0101 0.0188
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0085
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0094 0.0261 0.0253
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0019 0.0033 0.0047
Schistosoma mansoni hypothetical protein 0.0205 0.0597 0.1114
Echinococcus granulosus kelch ECH associated protein 1 0.0114 0.0322 0.0314
Echinococcus granulosus sodium and chloride dependent glycine 0.0026 0.0054 0.0045
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Schistosoma mansoni glutamate receptor NMDA 0.0056 0.0145 0.0271
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0094 0.0261 0.0488
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.0261 0.0253
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0037 0.0088 0.008
Brugia malayi Serotonin receptor 0.0546 0.1633 0.3039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.0261 0.0253
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0261 0.0488
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.0261 0.0253
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0026 0.0054 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.0261 0.0253
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0094 0.0261 0.0488
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0011 0.0009 0.0001
Echinococcus granulosus g protein coupled receptor 0.0094 0.0261 0.0253
Echinococcus granulosus kelch ECH associated protein 1 like 0.0114 0.0322 0.0314
Schistosoma mansoni opsin-like receptor 0.0094 0.0261 0.0488
Schistosoma mansoni opsin-like receptor 0.0094 0.0261 0.0488
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.013 0.0121
Loa Loa (eye worm) glutaminase 0.033 0.0977 0.1812
Brugia malayi hypothetical protein 0.0094 0.0261 0.0473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.013 0.0242
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0204 0.0596 0.0588
Brugia malayi hypothetical protein 0.0019 0.0033 0.0047
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0062 0.0539
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0002
Echinococcus granulosus serotonin transporter 0.0151 0.0435 0.0427
Echinococcus granulosus biogenic amine 5HT receptor 0.0094 0.0261 0.0253
Echinococcus multilocularis neuropeptide Y receptor 0.0094 0.0261 0.0253
Echinococcus multilocularis somatostatin receptor 0.0094 0.0261 0.0253
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.013 0.0121
Schistosoma mansoni glutamate receptor NMDA 0.0037 0.0088 0.0164
Brugia malayi hypothetical protein 0.0043 0.0108 0.0186
Schistosoma mansoni neuropeptide receptor 0.0094 0.0261 0.0488
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.0054 0.0101
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus multilocularis tyrosine kinase 0.0019 0.0033 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0322 0.0601
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0094 0.0261 0.0473
Loa Loa (eye worm) RGC/RGC protein kinase 0.0019 0.0033 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0261 0.0488
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0054 0.008
Onchocerca volvulus 0.0026 0.0054 0.0085
Onchocerca volvulus 0.0151 0.0435 0.0798
Echinococcus granulosus g protein coupled receptor 0.0094 0.0261 0.0253
Echinococcus granulosus neuropeptide receptor 0.0094 0.0261 0.0253
Onchocerca volvulus 0.0019 0.0033 0.0047
Echinococcus multilocularis NMDA receptor 0.0037 0.0088 0.008
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0094 0.0261 0.0488
Schistosoma mansoni hypothetical protein 0.0019 0.0034 0.0063
Echinococcus granulosus sex peptide receptor 0.0094 0.0261 0.0253
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0054 0.0085
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0037 0.0088 0.008
Echinococcus granulosus neuropeptide Y receptor 0.0094 0.0261 0.0253
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0094 0.0261 0.0488
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0322 0.3229
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0039 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0208 0.0388
Loa Loa (eye worm) hypothetical protein 0.0084 0.0231 0.0416
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0094 0.0261 0.0473
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0094 0.0261 0.0473
Echinococcus multilocularis g protein coupled receptor 0.0094 0.0261 0.0253
Schistosoma mansoni amine GPCR 0.0094 0.0261 0.0488
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0094 0.0261 0.0488
Schistosoma mansoni neuropeptide f receptor 76f 0.0094 0.0261 0.0488
Schistosoma mansoni growth hormone secretagogue receptor 0.0094 0.0261 0.0488
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0047
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0037 0.0088 0.008
Brugia malayi RNA, U transporter 1 0.0099 0.0276 0.0501
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0056 0.0145 0.0137
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0054 0.6214
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0094 0.0261 0.0253
Schistosoma mansoni hypothetical protein 0.0094 0.0261 0.0488
Loa Loa (eye worm) hypothetical protein 0.0151 0.0435 0.0798
Brugia malayi hypothetical protein 0.0094 0.0261 0.0473
Schistosoma mansoni neuropeptide receptor 0.0094 0.0261 0.0488
Brugia malayi neuropeptide F receptor 0.0094 0.0261 0.0473
Schistosoma mansoni glutamate receptor kainate 0.0037 0.0088 0.0164
Echinococcus multilocularis vesicular acetylcholine transporter 0.1773 0.5356 0.5352
Onchocerca volvulus 0.0094 0.0261 0.0473
Brugia malayi G-protein coupled receptor 0.0094 0.0261 0.0473
Echinococcus multilocularis kelch ECH associated protein 1 0.0114 0.0322 0.0314
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0009 0.0001
Entamoeba histolytica hypothetical protein 0.0028 0.0062 0.1419
Trichomonas vaginalis glutaminase, putative 0.033 0.0977 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0094 0.0261 0.0253
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0009 0.0002
Treponema pallidum sodium- and chloride- dependent transporter 0.0151 0.0435 1
Onchocerca volvulus 0.0365 0.1083 0.201
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0094 0.0261 0.0253
Echinococcus granulosus alpha 1A adrenergic receptor 0.0094 0.0261 0.0253
Echinococcus multilocularis snurportin 1 0.0372 0.1104 0.1096
Plasmodium falciparum amino acid transporter, putative 0.0026 0.0054 0.348
Echinococcus multilocularis neuropeptide receptor 0.0094 0.0261 0.0253
Echinococcus multilocularis neuropeptide s receptor 0.0094 0.0261 0.0253
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0322 0.3229
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0054 0.3429
Schistosoma mansoni adenoreceptor 0.0094 0.0261 0.0488
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0039 0.0057
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0019 0.0033 0.0047
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0151 0.0435 0.0813
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0047
Onchocerca volvulus 0.0094 0.0261 0.0473
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0047
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.013 0.0227
Echinococcus granulosus biogenic amine 5HT receptor 0.0094 0.0261 0.0253
Schistosoma mansoni amine GPCR 0.0094 0.0261 0.0488
Loa Loa (eye worm) G-protein coupled receptor 0.0094 0.0261 0.0473
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0017
Schistosoma mansoni myosin xvIII 0.0094 0.0261 0.0488
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0027 0.0057 0.0089
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0026 0.0054 0.0045
Echinococcus multilocularis fmrfamide receptor 0.0094 0.0261 0.0253
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.0322 0.066
Brugia malayi GnHR receptor homolog 0.0094 0.0261 0.0473
Schistosoma mansoni histamine h1 receptor 0.0094 0.0261 0.0488
Brugia malayi metabotropic glutamate receptor type 2 0.0019 0.0033 0.0047
Onchocerca volvulus 0.0094 0.0261 0.0473
Echinococcus granulosus allatostatin A receptor 0.0094 0.0261 0.0253
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0095 0.0263 0.2388
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0094 0.0261 0.0473
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0009 0.0001
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0009 0.0001
Schistosoma mansoni hypothetical protein 0.0037 0.0088 0.0164
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0208 0.0388
Onchocerca volvulus 0.0016 0.0024 0.0028
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0039 0.5
Onchocerca volvulus 0.0094 0.0261 0.0473
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0056 0.0145 0.0137
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0011 0.0009 0.0002
Loa Loa (eye worm) TYRA-2 protein 0.0094 0.0261 0.0473
Loa Loa (eye worm) glutamate receptor 1 0.0037 0.0088 0.0149
Leishmania major importin beta-1 subunit, putative 0.0028 0.0062 0.0064
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0054 0.0101
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0039 0.0057
Brugia malayi Melatonin receptor type 1A 0.0094 0.0261 0.0473
Echinococcus multilocularis sex peptide receptor 0.0094 0.0261 0.0253
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0026 0.0054 0.0101
Loa Loa (eye worm) RGC/RGC protein kinase 0.0019 0.0033 0.0047
Loa Loa (eye worm) hypothetical protein 0.0218 0.0637 0.1176
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0008 0.0016
Schistosoma mansoni neuropeptide receptor 0.0094 0.0261 0.0488
Brugia malayi putative neuropeptide receptor NPR1 0.0094 0.0261 0.0473
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0039 0.0047
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0019 0.0033 0.0025
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0008 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0322 0.3229
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0002
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0094 0.0261 0.0488
Echinococcus multilocularis conserved hypothetical protein 0.0678 0.2034 0.2027
Plasmodium falciparum importin beta, putative 0.0035 0.0082 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0208 0.0388
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0094 0.0261 0.0253
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0019 0.0033 0.0047
Schistosoma mansoni glutamate receptor kainate 0.0037 0.0088 0.0164
Schistosoma mansoni biogenic amine receptor 0.0094 0.0261 0.0488
Schistosoma mansoni metabotropic glutamate receptor 0.0019 0.0033 0.0062
Onchocerca volvulus 0.0094 0.0261 0.0473
Leishmania major GTP-binding protein, putative 0.0026 0.0054 0.0046
Echinococcus granulosus neuropeptide receptor 0.0094 0.0261 0.0253
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0056 0.0145 0.0137
Echinococcus granulosus geminin 0.0205 0.0597 0.0589
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Toxoplasma gondii hypothetical protein 0.0026 0.0054 0.6214
Schistosoma mansoni vesicular acetylcholine transporter 0.1773 0.5356 1
Echinococcus multilocularis neuropeptide Y receptor 0.0094 0.0261 0.0253
Echinococcus granulosus sodium and chloride dependent glycine 0.0026 0.0054 0.0045
Echinococcus granulosus atrial natriuretic peptide receptor 0.0019 0.0033 0.0025
Schistosoma mansoni sodium/chloride dependent transporter 0.0151 0.0435 0.0813
Brugia malayi hypothetical protein 0.0084 0.0231 0.0416
Schistosoma mansoni dep domain containing protein 0.0011 0.0008 0.0016
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0094 0.0261 0.0253
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0261 0.0488
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.0322 0.0586
Loa Loa (eye worm) glutaminase 2 0.033 0.0977 0.1812
Toxoplasma gondii exonuclease III APE 0.0021 0.0039 0.4192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0261 0.0488
Trypanosoma cruzi extracellular receptor, putative 0.0019 0.0033 0.0034
Brugia malayi hypothetical protein 0.0365 0.1083 0.201
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0009 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0261 0.0488
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0034 0.0047
Schistosoma mansoni biogenic amine receptor 0.0094 0.0261 0.0488
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0017
Brugia malayi ORL1-like opioid receptor 0.0094 0.0261 0.0473
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0034 0.0025
Echinococcus multilocularis glutamate receptor 2 0.0019 0.0033 0.0025
Brugia malayi Tachykinin-like peptides receptor 99D 0.0094 0.0261 0.0473
Schistosoma mansoni neuropeptide F-like receptor 0.0094 0.0261 0.0488
Echinococcus granulosus kelch ECH associated protein 1 like 0.0114 0.0322 0.0314
Brugia malayi hypothetical protein 0.0094 0.0261 0.0473
Brugia malayi hypothetical protein 0.0094 0.0261 0.0473
Brugia malayi hypothetical protein 0.0094 0.0261 0.0473
Schistosoma mansoni neuropeptide receptor 0.0094 0.0261 0.0488
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0132 0.0375 0.0367
Echinococcus granulosus metabotropic glutamate receptor 5 0.0019 0.0033 0.0025
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0054 0.0101
Echinococcus multilocularis sodium and chloride dependent glycine 0.0026 0.0054 0.0045
Loa Loa (eye worm) melatonin receptor type 1A 0.0094 0.0261 0.0473
Echinococcus granulosus GPCR family 2 0.0019 0.0034 0.0025
Echinococcus granulosus snurportin 1 0.0372 0.1104 0.1096
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.0261 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0322 0.3229
Loa Loa (eye worm) G-protein coupled receptor 0.0094 0.0261 0.0473
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0094 0.0261 0.0488
Echinococcus multilocularis G protein coupled receptor 139 0.0094 0.0261 0.0253
Echinococcus multilocularis glutamate receptor 2 0.0056 0.0145 0.0137
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0057 0.0149 0.4306
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0085
Brugia malayi Guanylyl cyclase protein 23 0.0019 0.0033 0.0047
Brugia malayi hypothetical protein 0.0094 0.0261 0.0473
Loa Loa (eye worm) hypothetical protein 0.0747 0.2241 0.4175
Entamoeba histolytica Ran family GTPase 0.0026 0.0054 0.1158
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Trypanosoma brucei polo-like protein kinase 0.0114 0.0322 0.0691
Schistosoma mansoni amine GPCR 0.0094 0.0261 0.0488
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Brugia malayi Metabotropic glutamate receptor precursor. 0.0019 0.0033 0.0047
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0039 0.0307
Loa Loa (eye worm) serotonin transporter b 0.0151 0.0435 0.0798
Onchocerca volvulus 0.0094 0.0261 0.0473
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0054 0.008
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0019 0.0033 0.0025
Brugia malayi G protein-coupled receptor F59B2.13 0.0094 0.0261 0.0473
Echinococcus granulosus nmda type glutamate receptor 0.0019 0.0033 0.0025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0039 0.0047
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0094 0.0261 0.0253
Brugia malayi larval opioid receptor 0.0094 0.0261 0.0473
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0009 0.0017
Echinococcus granulosus vesicular acetylcholine transporter 0.1773 0.5356 0.5352
Schistosoma mansoni importin beta-1 0.0035 0.0082 0.0152
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0095 0.0263 0.5656
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0094 0.0261 0.0488
Schistosoma mansoni glutamate receptor AMPA 0.0037 0.0088 0.0164
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0026 0.0054 0.0045
Loa Loa (eye worm) solute carrier family 6 member 4 0.0151 0.0435 0.0798
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0261 0.0488
Brugia malayi putative neuropeptide receptor 0.0094 0.0261 0.0473
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0054 0.0085
Trichomonas vaginalis hypothetical protein 0.0041 0.01 0.0936
Schistosoma mansoni glutamate receptor AMPA 0.0037 0.0088 0.0164
Schistosoma mansoni biogenic amine (5HT) receptor 0.0094 0.0261 0.0488
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0047
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0019 0.0033 0.0025
Entamoeba histolytica hypothetical protein 0.0043 0.0108 0.2939
Onchocerca volvulus 0.0094 0.0261 0.0473
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0054 0.0085
Schistosoma mansoni ran 0.0026 0.0054 0.01
Echinococcus multilocularis neuropeptides capa receptor 0.0094 0.0261 0.0253
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0011 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Schistosoma mansoni ap endonuclease 0.0021 0.0039 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0261 0.0488
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.013 0.0121
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus granulosus neuropeptide Y receptor 0.0094 0.0261 0.0253
Echinococcus granulosus neuropeptide s receptor 0.0094 0.0261 0.0253
Echinococcus multilocularis g-protein coupled receptor 0.0094 0.0261 0.0253
Brugia malayi hypothetical protein 0.0026 0.0054 0.0085
Echinococcus granulosus tyrosine kinase 0.0019 0.0033 0.0025
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0208 0.0373
Brugia malayi sulfakinin receptor protein 0.0094 0.0261 0.0473
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0034 0.0025
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0056 0.0145 0.0137
Brugia malayi hypothetical protein 0.0094 0.0261 0.0473
Loa Loa (eye worm) hypothetical protein 0.0151 0.0435 0.0798
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.0261 0.0253
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0047
Echinococcus multilocularis g protein coupled receptor 0.0094 0.0261 0.0253
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0159 0.0281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0261 0.0488
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0108 0.0201
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.0261 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0322 0.3229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.0261 0.0253
Schistosoma mansoni ran 0.0026 0.0054 0.01
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0037 0.0088 0.008
Echinococcus granulosus glutamate receptor subunit protein glur 0.0037 0.0088 0.008
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0054 0.0101
Schistosoma mansoni biogenic amine receptor 0.0094 0.0261 0.0488
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0034 0.0047
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Entamoeba histolytica hypothetical protein 0.0043 0.0108 0.2939
Onchocerca volvulus Neuropeptide F receptor homolog 0.0094 0.0261 0.0473
Echinococcus granulosus glutamate receptor 2 0.0019 0.0033 0.0025
Schistosoma mansoni glutaminase 0.033 0.0977 0.1825
Schistosoma mansoni hypothetical protein 0.0019 0.0034 0.0063
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0054 0.0101
Loa Loa (eye worm) hypothetical protein 0.0245 0.072 0.1331
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus multilocularis serotonin transporter 0.0151 0.0435 0.0427
Brugia malayi neuropeptide F receptor 0.0094 0.0261 0.0473
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0094 0.0261 0.0473
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.0261 0.0253
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0026 0.0054 0.0045
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0101 0.0173
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0147 0.1424
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.0055 0.0103
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0094 0.0261 0.0253
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0054 0.0045
Giardia lamblia Kinase, PLK 0.0114 0.0322 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0034 0.0025
Schistosoma mansoni hypothetical protein 0.0043 0.0108 0.0201
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0094 0.0261 0.0253
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0095 0.0263 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0026 0.0054 0.0085
Trichomonas vaginalis ran, putative 0.0026 0.0054 0.0458
Entamoeba histolytica hypothetical protein 0.0043 0.0108 0.2939
Echinococcus granulosus hypothetical protein 0.0772 0.2319 0.2313
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0204 0.0596 0.0588
Schistosoma mansoni hypothetical protein 0.0019 0.0034 0.0063
Schistosoma mansoni biogenic amine (5HT) receptor 0.0094 0.0261 0.0488
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0026 0.0054 0.0045
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus multilocularis neuropeptide receptor 0.0094 0.0261 0.0253
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0322 0.0691
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus granulosus tar DNA binding protein 0.0076 0.0208 0.02
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0039 0.0031
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0094 0.0261 0.0473
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0026 0.0054 0.0045
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0208 0.02
Echinococcus granulosus serotonin receptor 0.0094 0.0261 0.0253
Onchocerca volvulus 0.0094 0.0261 0.0473
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.0261 0.0253
Schistosoma mansoni hypothetical protein 0.0372 0.1104 0.2061
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1104 0.2048
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0054 0.0085
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0056 0.0145 0.0137
Schistosoma mansoni tsg101-related 0.007 0.0188 0.0351
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0011 0.0009 0.0002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0108 0.0099
Brugia malayi hypothetical protein 0.0094 0.0261 0.0473
Echinococcus multilocularis neuropeptide receptor A26 0.0094 0.0261 0.0253
Echinococcus multilocularis fmrfamide receptor 0.0094 0.0261 0.0253
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0019 0.0033 0.0047
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0094 0.0261 0.0488
Loa Loa (eye worm) hypothetical protein 0.0151 0.0435 0.0798
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0094 0.0261 0.0253
Onchocerca volvulus 0.0094 0.0261 0.0473
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0054 0.6214
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0095 0.0263 1
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0008 0.0016
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.0322 0.0314
Echinococcus granulosus tm gpcr rhodopsin 0.0094 0.0261 0.0253
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0.0054 0.0085
Brugia malayi Importin beta-1 subunit 0.0035 0.0082 0.0137
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0085
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0085
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.0322 0.0314
Schistosoma mansoni amine GPCR 0.0094 0.0261 0.0488
Schistosoma mansoni hypothetical protein 0.0019 0.0034 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.0261 0.0488
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0094 0.0261 0.0253
Schistosoma mansoni tsg101-related 0.007 0.0188 0.0351
Echinococcus granulosus 7tm_1 domain containing protein 0.0094 0.0261 0.0253
Echinococcus granulosus g-protein coupled receptor 0.0094 0.0261 0.0253
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0084 0.0231 0.0222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.0261 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0147 0.1424
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0208 0.0373
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0019 0.0033 0.0047
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0054 0.008
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0026 0.0054 0.0101
Loa Loa (eye worm) neuropeptide F receptor 0.0094 0.0261 0.0473
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0054 0.0101
Brugia malayi vesicular acetylcholine transporter unc-17 0.1773 0.5356 1
Onchocerca volvulus 0.0026 0.0054 0.0085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.013 0.0242
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0094 0.0261 0.0253
Brugia malayi Serotonin receptor 0.0094 0.0261 0.0473
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0094 0.0261 0.0473
Schistosoma mansoni hypothetical protein 0.0094 0.0261 0.0488
Echinococcus granulosus neuropeptide FF receptor 2 0.0094 0.0261 0.0253
Echinococcus granulosus tm gpcr rhodopsin 0.0094 0.0261 0.0253
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0094 0.0261 0.0253
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0009 0.0001
Echinococcus multilocularis sodium and chloride dependent glycine 0.0026 0.0054 0.0045
Brugia malayi Cyclic-nucleotide gated cation channel 0.0011 0.0009 0.0002
Brugia malayi Glutamate receptor 2 precursor 0.0037 0.0088 0.0149
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0082 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.0261 0.0253
Plasmodium vivax importin-beta 2, putative 0.0035 0.0082 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0019 0.0033 0.0047
Loa Loa (eye worm) hypothetical protein 0.0041 0.0101 0.0173
Echinococcus multilocularis Kelch repeat type 1 0.0114 0.0323 0.0315
Echinococcus multilocularis allatostatin A receptor 0.0094 0.0261 0.0253
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Loa Loa (eye worm) RNA binding protein 0.0076 0.0208 0.0373
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Brugia malayi AKH receptor 0.0094 0.0261 0.0473
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.013 0.0121
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0039 0.0031
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0082 1
Brugia malayi Receptor family ligand binding region containing protein 0.0019 0.0033 0.0047
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0039 0.0307
Echinococcus multilocularis kelch ECH associated protein 1 0.0114 0.0322 0.0314
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0094 0.0261 0.0488
Schistosoma mansoni tyrosine kinase 0.0019 0.0033 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.0095
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0094 0.0261 0.0253
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0094 0.0261 0.0253
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.0322 0.0586
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0094 0.0261 0.0473
Leishmania major hypothetical protein, conserved 0.0027 0.0057 0.0055
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0094 0.0261 0.0488
Echinococcus multilocularis serotonin receptor 0.0094 0.0261 0.0253
Loa Loa (eye worm) neuropeptide F receptor 0.0094 0.0261 0.0473
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0017
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0094 0.0261 0.0253
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0009 0.0001
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0027 0.0057 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0322 0.3229
Entamoeba histolytica hypothetical protein 0.0043 0.0108 0.2939
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Brugia malayi glutaminase DH11.1 0.033 0.0977 0.1812
Echinococcus granulosus tachykinin peptides receptor 99D 0.0094 0.0261 0.0253
Onchocerca volvulus 0.0094 0.0261 0.0473
Schistosoma mansoni dishevelled 0.0011 0.0008 0.0016
Echinococcus granulosus fmrfamide receptor 0.0094 0.0261 0.0253
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.0322 1
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0017
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0159 0.0281
Echinococcus granulosus neuropeptides capa receptor 0.0094 0.0261 0.0253
Echinococcus multilocularis neuropeptide FF receptor 2 0.0094 0.0261 0.0253
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0.0054 0.0085
Schistosoma mansoni tyrosine kinase 0.0019 0.0033 0.0062
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0151 0.0435 0.0798
Echinococcus multilocularis dro:myosuppressin receptor 0.0094 0.0261 0.0253
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0094 0.0261 0.0488
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.3304 1 1
Schistosoma mansoni hypothetical protein 0.0114 0.0323 0.0603
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0047
Schistosoma mansoni opsin-like receptor 0.0094 0.0261 0.0488
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0062 0.0098
Onchocerca volvulus 0.0094 0.0261 0.0473
Schistosoma mansoni sodium-dependent amino acid transporter 0.0026 0.0054 0.0101
Echinococcus granulosus receptor type guanylyl cyclase 0.0019 0.0033 0.0025
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0094 0.0261 0.0488
Schistosoma mansoni amine GPCR 0.0094 0.0261 0.0488
Loa Loa (eye worm) glutamate receptor 2 0.0037 0.0088 0.0149
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0009 0.0001
Brugia malayi Dopamine receptor protein 2 0.0094 0.0261 0.0473
Echinococcus granulosus 7TM GPCR rhodopsin 0.0094 0.0261 0.0253
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Brugia malayi hypothetical protein 0.0094 0.0261 0.0473
Schistosoma mansoni dishevelled 0.0011 0.0008 0.0016
Onchocerca volvulus 0.0019 0.0033 0.0047
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0094 0.0261 0.0473
Onchocerca volvulus 0.0094 0.0261 0.0473
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0056 0.0145 0.0137
Echinococcus granulosus importin subunit beta 1 0.0035 0.0082 0.0073
Echinococcus granulosus neuropeptides capa receptor 0.0094 0.0261 0.0253
Echinococcus multilocularis serotonin receptor 0.0094 0.0261 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.0095
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0009 0.0017
Schistosoma mansoni metabotropic glutamate receptor 0.0019 0.0033 0.0062
Schistosoma mansoni tsg101-related 0.0057 0.0149 0.0279
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0056 0.0145 0.0137
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0208 0.0388
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0322 0.3229
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0034 0.0047
Echinococcus granulosus somatostatin receptor 0.0094 0.0261 0.0253
Entamoeba histolytica hypothetical protein 0.0019 0.0033 0.0489
Onchocerca volvulus 0.0094 0.0261 0.0473
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.0261 0.0253
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus granulosus dro:myosuppressin receptor 0.0094 0.0261 0.0253
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Onchocerca volvulus 0.0094 0.0261 0.0473
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0062 0.0539
Loa Loa (eye worm) hypothetical protein 0.0365 0.1083 0.201
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0009 0.0001
Echinococcus granulosus glutamate receptor 2 0.0056 0.0145 0.0137
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0054 0.6184
Echinococcus multilocularis G-protein coupled receptor, putative 0.0094 0.0261 0.0253
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0094 0.0261 0.0253
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0054 0.3429
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0009 0.0017
Toxoplasma gondii hypothetical protein 0.0026 0.0054 0.6214
Loa Loa (eye worm) hypothetical protein 0.1461 0.4408 0.8227
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0037 0.0088 0.008
Onchocerca volvulus 0.0094 0.0261 0.0473
Brugia malayi RNA binding protein 0.0076 0.0208 0.0373
Schistosoma mansoni hypothetical protein 0.0094 0.0261 0.0488
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0245 0.072 0.1331
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0054 0.0045
Echinococcus granulosus metabotropic glutamate receptor 2 0.0019 0.0033 0.0025
Brugia malayi hypothetical protein 0.0094 0.0261 0.0473
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0208 0.0373
Echinococcus granulosus neuropeptide receptor A26 0.0094 0.0261 0.0253
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0039 0.0013
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.1773 0.5356 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0208 0.0388
Trypanosoma brucei C-8 sterol isomerase, putative 0.1461 0.4408 1
Loa Loa (eye worm) norepinephrine transporter 0.0151 0.0435 0.0798
Brugia malayi Receptor family ligand binding region containing protein 0.0019 0.0033 0.0047
Schistosoma mansoni hypothetical protein 0.0205 0.0597 0.1114
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0084 0.0231 0.0222
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0037 0.0088 0.008
Echinococcus multilocularis glutamate receptor 2 0.0037 0.0088 0.008
Brugia malayi follicle stimulating hormone receptor 0.0094 0.0261 0.0473
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0039 0.0678
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0011 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0085
Brugia malayi N-terminal motif family protein 0.0218 0.0637 0.1176
Echinococcus multilocularis orexin receptor type 2 0.0094 0.0261 0.0253
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Schistosoma mansoni glutamate receptor kainate 0.0037 0.0088 0.0164
Echinococcus multilocularis g protein coupled receptor 0.0094 0.0261 0.0253
Brugia malayi G-protein coupled receptor 0.0094 0.0261 0.0473
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1461 0.4408 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0094 0.0261 0.0253
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.0322 0.0586
Onchocerca volvulus 0.0094 0.0261 0.0473
Echinococcus granulosus g protein coupled receptor 0.0094 0.0261 0.0253
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0085
Brugia malayi Dopamine receptor protein 1 0.0094 0.0261 0.0473
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1461 0.4408 0.8227
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0054 0.0101
Loa Loa (eye worm) glutamate receptor 0.0019 0.0033 0.0047
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0082 0.0144
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0011 0.0009 0.0001
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0009 0.0017
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0322 0.0691
Schistosoma mansoni ATP-binding cassette transporter 0.0037 0.0088 0.0164
Echinococcus multilocularis receptor type guanylyl cyclase 0.0019 0.0033 0.0025
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Echinococcus multilocularis nmda type glutamate receptor 0.0132 0.0375 0.0367
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.0637 0.1176
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.013 0.0242
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0009 0.0017
Schistosoma mansoni hypothetical protein 0.0094 0.0261 0.0488
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0094 0.0261 0.0253
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0054 0.348
Schistosoma mansoni neuropeptide F-like receptor 0.0094 0.0261 0.0488
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0094 0.0261 0.0473
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0082 0.0144
Onchocerca volvulus 0.0094 0.0261 0.0473
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0108 0.0099
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0011 0.0009 0.0001
Echinococcus multilocularis neuropeptides capa receptor 0.0094 0.0261 0.0253
Echinococcus multilocularis nmda type glutamate receptor 0.0019 0.0033 0.0025
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0094 0.0261 0.0253
Brugia malayi RE15519p 0.0094 0.0261 0.0473
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0062 0.0539
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.0261 0.0253
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.013 0.0227
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0037 0.0088 0.008
Echinococcus granulosus orexin receptor type 2 0.0094 0.0261 0.0253
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0054 0.0085
Brugia malayi Dopamine receptor 0.0094 0.0261 0.0473
Loa Loa (eye worm) hypothetical protein 0.0094 0.0261 0.0473
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0094 0.0261 0.0473
Schistosoma mansoni ap endonuclease 0.0021 0.0039 0.0073
Leishmania major C-8 sterol isomerase-like protein 0.1461 0.4408 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0047
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0056 0.0145 0.0137
Brugia malayi G protein-coupled receptor 0.0094 0.0261 0.0473
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0137
Echinococcus granulosus nmda type glutamate receptor 0.0132 0.0375 0.0367
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0054 0.6214
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0026 0.0054 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0047
Mycobacterium ulcerans glutaminase 0.033 0.0977 1
Chlamydia trachomatis glutamine binding protein 0.0095 0.0263 1
Echinococcus granulosus glutamate NMDA receptor subunit 0.0037 0.0088 0.008
Schistosoma mansoni protein kinase 0.0019 0.0033 0.0062
Brugia malayi TAR-binding protein 0.0076 0.0208 0.0373
Echinococcus multilocularis geminin 0.0205 0.0597 0.0589
Onchocerca volvulus 0.0026 0.0054 0.0085
Plasmodium vivax amine transporter, putative 0.0026 0.0054 0.348

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 2.01 uM PUBCHEM_BIOASSAY: Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504540] ChEMBL. No reference
EC50 (functional) = 4.79 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 39.19 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 41.3 uM PUBCHEM_BIOASSAY: Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) = 54.3 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
IC50 (functional) > 80 uM PUBCHEM_BIOASSAY: Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504690, AID504696] ChEMBL. No reference
K0.5 (binding) = 4000 nM Compound was tested for the displacement of [3H]-mepyramine from Histamine H1 receptor by competition binding assay. ChEMBL. 10447948
K0.5 (binding) = 4800 nM Displacement of [3H]-(-)-trans-H2-PAT from histamine H2 PAT binding site by competition binding assay. ChEMBL. 10447948
K0.5 (binding) = 4800 nM Displacement of [3H]-(-)-trans-H2-PAT from histamine H2 PAT binding site by competition binding assay. ChEMBL. 10447948
LogP = 4.2 Partition coefficient, log P of the compound ChEMBL. 17482318
Max_Activity_Concent (functional) 50 uM PubChem BioAssay. Thermal shift assay to identify compound binding to Kelch domain of Keap1 protein Measured in Biochemical System Using RT-PCR - 2119-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Max_Concentration (binding) 6 uM PubChem BioAssay. Counterscreen to eliminate false positive from thermal shift assay Measured in Biochemical System Using Plate Reader - 2119-07_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3109 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1095 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1095 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.6109 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.1905 uM PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.2 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.4662 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 22.1108 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.1108 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 24.8087 uM PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 24.8087 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 24.8087 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 27.8358 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 30.9497 uM PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.1168 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Solubility = 0.715 g/L Solubility in water ChEMBL. 17482318

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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