Detailed information for compound 1688544

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 524.527 | Formula: C28H24N6O5
  • H donors: 0 H acceptors: 6 LogP: 4.13 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)c1nc(n(n1)COCCOC(=O)C)c1nnn(c1)Cc1ccc2c3c1ccc1c3c(cc2)ccc1
  • InChi: 1S/C28H24N6O5/c1-17(35)39-13-12-38-16-34-27(29-26(31-34)28(36)37-2)23-15-33(32-30-23)14-21-9-8-20-7-6-18-4-3-5-19-10-11-22(21)25(20)24(18)19/h3-11,15H,12-14,16H2,1-2H3
  • InChiKey: MUZRLONFIZTTIJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0695 0.1257
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0152 0.0144
Echinococcus granulosus cpg binding protein 0.0032 0.0294 0.0536
Echinococcus multilocularis tyrosine protein kinase otk 0.0067 0.0695 0.0688
Schistosoma mansoni ap endonuclease 0.0018 0.0133 0.0253
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0329 0.7926
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0067 0.0695 0.6688
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0319 0.364 1
Loa Loa (eye worm) hypothetical protein 0.0144 0.1602 0.2962
Schistosoma mansoni alpha glucosidase 0.0035 0.0329 0.065
Schistosoma mansoni nuclear hormone receptor 0.002 0.0152 0.0291
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0152 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0152 0.0233
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0695 0.1257
Trichomonas vaginalis ran, putative 0.0021 0.0159 0.3823
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0042 0.0027
Schistosoma mansoni nephrin 0.0067 0.0695 0.1389
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.364 1
Brugia malayi Immunoglobulin domain containing protein 0.0067 0.0695 0.1257
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0152 0.0144
Echinococcus granulosus dnaJ subfamily B 0.0432 0.4958 0.9284
Echinococcus multilocularis hemicentin 1 0.0067 0.0695 0.0688
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0329 0.7926
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0695 0.1257
Loa Loa (eye worm) hypothetical protein 0.0067 0.0695 0.1254
Loa Loa (eye worm) hypothetical protein 0.0144 0.1602 0.2962
Echinococcus multilocularis Immunoglobulin 0.0238 0.2699 0.2694
Brugia malayi hypothetical protein 0.0016 0.0109 0.0153
Schistosoma mansoni alpha-glucosidase 0.0136 0.1508 0.3031
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0274 0.046
Loa Loa (eye worm) hypothetical protein 0.0067 0.0695 0.1254
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0152 0.027
Echinococcus granulosus tyrosine protein kinase otk 0.0067 0.0695 0.129
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0231
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0329 0.7926
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0029 0.0022
Schistosoma mansoni nuclear receptor 0.0009 0.0029 0.0044
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0152 0.1231
Schistosoma mansoni neuroglian 0.0067 0.0695 0.1389
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0072 0.1742
Echinococcus granulosus low density lipoprotein receptor ldl 0.0067 0.0695 0.129
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0159 0.0242
Echinococcus multilocularis dnaJ subfamily B 0.0432 0.4958 0.4955
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0231
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.1605 0.297
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0152 0.0233
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0029 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0152 0.0233
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0152 0.0233
Schistosoma mansoni septate junction protein 0.0067 0.0695 0.1389
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0416 0.0765
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0029 0.004
Echinococcus granulosus nephrin 0.0238 0.2699 0.5048
Echinococcus multilocularis neuroglian 0.0067 0.0695 0.0688
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.1681 0.4507
Echinococcus multilocularis roundabout 2 0.0067 0.0695 0.0688
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0133 0.0125
Echinococcus granulosus neuroglian 0.0067 0.0695 0.129
Echinococcus multilocularis cpg binding protein 0.0032 0.0294 0.0286
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0042 0.0035
Schistosoma mansoni cell adhesion molecule 0.0067 0.0695 0.1389
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0029 0.0003
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0695 0.1257
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0329 0.7926
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0438 0.0807
Echinococcus multilocularis snurportin 1 0.0297 0.3387 0.3382
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0152 0.0233
Schistosoma mansoni hypothetical protein 0.0095 0.1025 0.2056
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0329 0.8513
Plasmodium falciparum importin beta, putative 0.0028 0.0245 0.4629
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0133 0.017
Loa Loa (eye worm) hypothetical protein 0.0067 0.0695 0.1254
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0231
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0416 0.567
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0029 0.0022
Schistosoma mansoni basigin related 0.0067 0.0695 0.1389
Schistosoma mansoni ap endonuclease 0.0018 0.0133 0.0253
Loa Loa (eye worm) hypothetical protein 0.0067 0.0695 0.1254
Leishmania major GTP-binding protein, putative 0.0021 0.0159 0.0242
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0042 0.0065
Schistosoma mansoni hypothetical protein 0.0067 0.0695 0.1389
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0329 0.3941
Brugia malayi steroid hormone receptor 0.002 0.0152 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0152 0.0233
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0133 0.017
Schistosoma mansoni nephrin related 0.0067 0.0695 0.1389
Loa Loa (eye worm) hypothetical protein 0.0067 0.0695 0.1254
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0329 0.7926
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0329 0.072
Onchocerca volvulus 0.0092 0.0987 0.9617
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0159 0.0247
Schistosoma mansoni hypothetical protein 0.0067 0.0695 0.1389
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0416 0.567
Echinococcus multilocularis irregular chiasm roughest protein immunoglobulin set domain containing protein 0.0238 0.2699 0.2694
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0067 0.0695 0.1389
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0305 0.3475 0.6488
Echinococcus multilocularis peroxidasin 0.0067 0.0695 0.0688
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.1681 0.4507
Loa Loa (eye worm) hypothetical protein 0.0028 0.0245 0.0405
Loa Loa (eye worm) hypothetical protein 0.0067 0.0695 0.1254
Schistosoma mansoni hypothetical protein 0.0067 0.0695 0.1389
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0438 0.077
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.1765 0.3271
Brugia malayi nuclear receptor NHR-88 0.0009 0.0029 0.0003
Echinococcus granulosus roundabout 2 0.0067 0.0695 0.129
Brugia malayi Heparan sulfate 0.0067 0.0695 0.1257
Echinococcus multilocularis muscleblind protein 0.0144 0.1602 0.1596
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0152 0.027
Trypanosoma brucei glucosidase, putative 0.0035 0.0329 0.072
Brugia malayi hypothetical protein 0.0025 0.0213 0.0348
Schistosoma mansoni septate junction protein 0.0067 0.0695 0.1389
Entamoeba histolytica hypothetical protein 0.0023 0.0183 0.3671
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0051 0.0044
Leishmania major mitochondrial DNA polymerase beta 0.0319 0.364 1
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0029 0.0044
Brugia malayi map kinase activated protein kinase protein 2 0.0218 0.2466 0.4589
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0159 0.0151
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0218 0.2466 0.246
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0438 0.0869
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0695 0.1257
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.1558 0.2908
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0133 0.0195
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0695 0.1257
Brugia malayi Immunoglobulin I-set domain containing protein 0.0305 0.3475 0.6489
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0067 0.0695 0.0688
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0245 0.2241
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0159 0.0242
Echinococcus granulosus lachesin 0.0067 0.0695 0.129
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0067 0.0695 0.0688
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0067 0.0695 0.0688
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0072 0.1742
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0159 0.0244
Schistosoma mansoni cpg binding protein 0.0032 0.0294 0.0578
Schistosoma mansoni zinc finger protein 0.0009 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0025
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0159 0.1076
Loa Loa (eye worm) hypothetical protein 0.0067 0.0695 0.1254
Brugia malayi basement membrane proteoglycan precursor 0.0067 0.0695 0.1257
Plasmodium vivax importin-beta 2, putative 0.0028 0.0245 0.3952
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0067 0.0695 0.1254
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0152 0.0291
Schistosoma mansoni ran 0.0021 0.0159 0.0305
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0072 0.1742
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0152 0.0291
Echinococcus granulosus survival motor neuron protein 1 0.0465 0.534 1
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0067 0.0695 0.1254
Brugia malayi hypothetical protein 0.0465 0.534 1
Schistosoma mansoni hypothetical protein 0.0067 0.0695 0.1389
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0329 0.0322
Brugia malayi Immunoglobulin domain containing protein 0.0067 0.0695 0.1257
Brugia malayi nuclear receptor RXR 0.0009 0.0029 0.0003
Loa Loa (eye worm) hypothetical protein 0.0067 0.0695 0.1254
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0329 0.072
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0152 0.0291
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0438 0.0772
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0152 0.0233
Schistosoma mansoni hypothetical protein 0.0238 0.2699 0.5437
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0329 0.7926
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0072 0.1742
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0029 0.0003
Echinococcus granulosus muscleblind protein 0.0144 0.1602 0.299
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0067 0.0695 0.1389
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.3387 0.6322
Echinococcus multilocularis roundabout 2 0.0067 0.0695 0.0688
Loa Loa (eye worm) hypothetical protein 0.0067 0.0695 0.1254
Echinococcus multilocularis netrin receptor unc 5 0.0067 0.0695 0.0688
Echinococcus granulosus contactin 0.0067 0.0695 0.129
Brugia malayi hypothetical protein 0.0009 0.0029 0.0003
Schistosoma mansoni netrin receptor unc5 0.0067 0.0695 0.1389
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0443 0.1039
Loa Loa (eye worm) acetyltransferase 0.0145 0.1605 0.2968
Mycobacterium ulcerans hypothetical protein 0.0168 0.1879 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0213 0.2834
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0067 0.0695 0.0688
Echinococcus granulosus geminin 0.0165 0.1839 0.3435
Schistosoma mansoni hypothetical protein 0.0067 0.0695 0.1389
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.1765 0.3269
Echinococcus granulosus peroxidasin 0.0067 0.0695 0.129
Echinococcus granulosus basement membrane specific heparan sulfate 0.0067 0.0695 0.129
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0067 0.0695 0.1389
Schistosoma mansoni alpha-glucosidase 0.0136 0.1508 0.3031
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0183 0.4408
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0438 0.0431
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0374 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0231
Schistosoma mansoni cell adhesion molecule 0.0067 0.0695 0.1389
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0159 0.0521
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0042 0.007
Echinococcus granulosus Immunoglobulin subtype 0.0067 0.0695 0.129
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0029 0.0003
Echinococcus granulosus roundabout 2 0.0067 0.0695 0.129
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0329 0.0603
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0152 0.0233
Echinococcus granulosus roundabout 2 0.0067 0.0695 0.129
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0329 0.0567
Onchocerca volvulus 0.003 0.0274 0.2453
Onchocerca volvulus 0.0095 0.1025 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0152 0.0233
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0152 0.027
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0152 0.1231
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0183 0.4408
Echinococcus granulosus Immunoglobulin 0.0238 0.2699 0.5048
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0067 0.0702 0.1267
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0213 0.0394
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0416 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0152 0.0231
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0159 0.0242
Loa Loa (eye worm) hypothetical protein 0.0067 0.0695 0.1254
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0067 0.0695 0.129
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0374 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0067 0.0695 0.1254
Brugia malayi tailless protein 0.0009 0.0029 0.0003
Echinococcus granulosus Immunoglobulin 0.0067 0.0695 0.129
Schistosoma mansoni hypothetical protein 0.0165 0.1839 0.37
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0133 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0025
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0443 0.1039
Loa Loa (eye worm) hypothetical protein 0.0025 0.0213 0.0346
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.1025 0.1878
Schistosoma mansoni cell adhesion molecule 0.0067 0.0695 0.1389
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0029 0.004
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0218 0.2466 0.4588
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0305 0.3475 0.6488
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.1605 0.3227
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0067 0.0695 0.0688
Echinococcus multilocularis Immunoglobulin 0.0067 0.0695 0.0688
Schistosoma mansoni basigin related 0.0067 0.0695 0.1389
Echinococcus granulosus FTZ F1 alpha 0.002 0.0152 0.027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0152 0.0231
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0213 0.0394
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0329 0.0565
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0329 0.8513
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0067 0.0695 0.129
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0152 0.027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0152 0.0231
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0695 0.1257
Brugia malayi nuclear receptor NHR-67 0.0009 0.0029 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0042 0.0027
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0152 0.0291
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0152 0.027
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0029 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0231
Loa Loa (eye worm) hypothetical protein 0.0465 0.534 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0072 0.1742
Brugia malayi conserved hypotetical protein 0.0009 0.0029 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.2466 0.4965
Schistosoma mansoni importin beta-1 0.0028 0.0245 0.0478
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0152 0.0233
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0133 0.3198
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0245 0.0483
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0443 0.1039
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0029 0.0044
Onchocerca volvulus 0.002 0.0152 0.1231
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0213 0.3319
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0631 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0245 0.0483
Toxoplasma gondii hypothetical protein 0.0051 0.052 0.7764
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0159 0.0283
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0152 0.0233
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0152 0.0231
Entamoeba histolytica Ran family GTPase 0.0021 0.0159 0.2865
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1765 0.1759
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0245 0.0237
Loa Loa (eye worm) hypothetical protein 0.0067 0.0695 0.1254
Echinococcus multilocularis geminin 0.0165 0.1839 0.1833
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0152 0.0233
Schistosoma mansoni netrin receptor unc5 0.0067 0.0695 0.1389
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0072 0.1742
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0152 0.0233
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0443 0.1039
Schistosoma mansoni cell adhesion molecule 0.0067 0.0695 0.1389
Echinococcus granulosus Immunoglobulin 0.0067 0.0695 0.129
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0029 0.0000011442
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0029 0.0022
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0695 0.1257
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0329 0.7926
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0067 0.0695 0.129
Loa Loa (eye worm) LAD-2 short isoform 0.0067 0.0695 0.1254
Brugia malayi Immunoglobulin I-set domain containing protein 0.0305 0.3475 0.6489
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0152 0.027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0695 0.1257
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0152 0.0144
Echinococcus multilocularis hemicentin 1 0.0067 0.0695 0.0688
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0072 0.1742
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0029 0.0022
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0029 0.0003
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0213 0.3319
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0067 0.0695 0.1254
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0557 0.1359
Brugia malayi hypothetical protein 0.0009 0.0029 0.0003
Loa Loa (eye worm) hypothetical protein 0.0067 0.0695 0.1254
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0133 0.0198
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0042 0.007
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0067 0.0695 0.129
Loa Loa (eye worm) hypothetical protein 0.0067 0.0695 0.1254
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0231
Loa Loa (eye worm) hypothetical protein 0.0067 0.0695 0.1254
Brugia malayi basement membrane proteoglycan 0.0067 0.0695 0.1257
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0159 0.0919
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0438 0.0807
Schistosoma mansoni survival motor neuron protein 0.0095 0.1025 0.2056
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0051 0.0082
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0152 0.0291
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0152 0.0231
Schistosoma mansoni coup transcription factor 0.002 0.0152 0.0291
Schistosoma mansoni hypothetical protein 0.0067 0.0695 0.1389
Brugia malayi nuclear hormone receptor 0.0009 0.0029 0.0003
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0067 0.0695 0.0688
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0133 0.3198
Brugia malayi Prion-like- 0.0067 0.0695 0.1257
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0072 0.0084
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0081
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0029 0.004
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0416 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0231
Leishmania major hypothetical protein, conserved 0.0025 0.0213 0.0394
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0695 0.1257
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0152 0.1231
Schistosoma mansoni hypothetical protein 0.0011 0.0051 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0025
Schistosoma mansoni hypothetical protein 0.0238 0.2699 0.5437
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0231
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0152 0.027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0152 0.0231
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.1681 0.4507
Schistosoma mansoni septate junction protein 0.0067 0.0695 0.1389
Schistosoma mansoni hypothetical protein 0.0165 0.1839 0.37
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0183 0.4408
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0067 0.0695 0.1389
Brugia malayi CXXC zinc finger family protein 0.003 0.0274 0.0463
Echinococcus granulosus irregular chiasm roughest protein 0.0238 0.2699 0.5048
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0133 0.017
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.364 1
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0067 0.0695 0.1389
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0029 0.004
Brugia malayi nuclear receptor RXR 0.0011 0.0042 0.0027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0152 0.0144
Schistosoma mansoni hypothetical protein 0.0297 0.3387 0.6825
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0072 0.0432
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0067 0.0695 0.1389
Echinococcus multilocularis lachesin 0.0067 0.0695 0.0688
Schistosoma mansoni cell adhesion molecule 0.0067 0.0695 0.1389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0152 0.0231
Echinococcus multilocularis nephrin 0.0238 0.2699 0.2694
Leishmania major importin beta-1 subunit, putative 0.0023 0.0183 0.0311
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1765 0.1759
Echinococcus granulosus netrin receptor unc 5 0.0067 0.0695 0.129
Mycobacterium tuberculosis Conserved hypothetical protein 0.0168 0.1879 1
Schistosoma mansoni hypothetical protein 0.0432 0.4958 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0152 0.0144
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0029 0.004
Brugia malayi Peroxidasin 0.0067 0.0695 0.1257
Brugia malayi Importin beta-1 subunit 0.0028 0.0245 0.0408
Echinococcus multilocularis survival motor neuron protein 1 0.0465 0.534 0.5336
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0029 0.0022
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0029 0.0003
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0029 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0438 0.0869
Echinococcus multilocularis conserved hypothetical protein 0.0238 0.2699 0.2694
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0067 0.0695 0.0688
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0067 0.0695 0.0688
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0159 0.1076
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0329 0.7926
Schistosoma mansoni tyrosine kinase 0.0067 0.0695 0.1389
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0029 0.0044
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0416 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0152 0.0291
Brugia malayi hypothetical protein 0.0305 0.3475 0.6489
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0067 0.0695 0.0688
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0152 0.0144
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0218 0.2466 0.461
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0152 0.0291
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0213 0.0394
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0695 0.1257
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0029 0.0003
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0695 0.1257
Echinococcus granulosus importin subunit beta 1 0.0028 0.0245 0.0444
Schistosoma mansoni basigin related 0.0067 0.0695 0.1389
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0029 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0152 0.0233
Brugia malayi ecdysone receptor 0.0009 0.0029 0.0003
Schistosoma mansoni peroxidasin 0.0067 0.0695 0.1389
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0152 0.0144
Echinococcus granulosus hemicentin 1 0.0067 0.0695 0.129
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0152 0.0233
Brugia malayi Immunoglobulin domain containing protein 0.0067 0.0695 0.1257
Schistosoma mansoni titin 0.0067 0.0695 0.1389
Echinococcus multilocularis Immunoglobulin subtype 0.0067 0.0695 0.0688
Brugia malayi Muscleblind-like protein 0.0144 0.1602 0.2964
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0695 0.1257
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.1765 0.3296
Brugia malayi nuclear hormone receptor 0.002 0.0152 0.0233
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0183 0.0311
Schistosoma mansoni cell adhesion molecule 0.0067 0.0695 0.1389
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0152 0.0291
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0152 0.0233
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0029 0.004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0029 0.004
Schistosoma mansoni septate junction protein 0.0067 0.0695 0.1389
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0133 0.2004
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0067 0.0695 0.0688
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0067 0.0695 0.0688
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0438 0.0431
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0329 0.072
Brugia malayi hypothetical protein 0.0011 0.0042 0.0027
Schistosoma mansoni ran 0.0021 0.0159 0.0305
Brugia malayi hypothetical protein 0.0011 0.0042 0.0027
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0152 0.0291
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0072 0.1742
Schistosoma mansoni cpg binding protein 0.0032 0.0294 0.0578
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.2543 0.4734
Schistosoma mansoni thyroid hormone receptor 0.002 0.0152 0.0291
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0067 0.0695 0.129
Echinococcus granulosus nephrin 0.0238 0.2699 0.5048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0438 0.0869
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0152 0.0144
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0133 0.5
Schistosoma mansoni thyroid hormone receptor 0.002 0.0152 0.0291
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0042 0.0025
Echinococcus multilocularis muscleblind protein 1 0.0144 0.1602 0.1596
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0329 0.7926
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0152 0.0231
Loa Loa (eye worm) hypothetical protein 0.0067 0.0695 0.1254
Brugia malayi RNA, U transporter 1 0.0079 0.0843 0.1535
Brugia malayi follicle stimulating hormone receptor 0.0225 0.2543 0.4735
Schistosoma mansoni nuclear receptor 0.0009 0.0029 0.0044
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0067 0.0695 0.1389
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0213 0.1607
Brugia malayi nuclear receptor NHR-88 0.002 0.0152 0.0233
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.067 0.1338
Echinococcus multilocularis Immunoglobulin 0.0067 0.0695 0.0688
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0133 0.017
Echinococcus multilocularis roundabout 2 0.0067 0.0695 0.0688
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0133 0.0235
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0152 0.027
Schistosoma mansoni cpg binding protein 0.003 0.0274 0.0537
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.1605 0.1599
Echinococcus granulosus snurportin 1 0.0297 0.3387 0.6337
Loa Loa (eye worm) hypothetical protein 0.0067 0.0695 0.1254
Schistosoma mansoni roundabout 0.0067 0.0695 0.1389
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0374 1
Brugia malayi ecdysteroid receptor 0.002 0.0152 0.0233

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 36.9 % Cell cycle arrest in multidrug-resistant human MIAPaCa2 cells assessed as accumulation at sub-G0/G1 phase after 48 hrs by propidium iodide staining based FACS flow cytometry (Rvb = 1.17%) ChEMBL. 22578090
IC50 (functional) <= 10 uM Cytotoxicity against multidrug-resistant human MIAPaCa2 cells assessed as cell viability after 48 hrs by MTT assay ChEMBL. 22578090

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 22578090

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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