TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 541.99 | Formula: C24H28ClN9O4
H donors: 5 H acceptors: 4 LogP: -0.93 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: Cl/C=C\C(=O)Nc1cc(n(c1)C)C(=O)Nc1cc(n(c1)C)C(=O)Nc1cc(n(c1)C)C(=O)NCCC(=N)N
InChi: 1S/C24H28ClN9O4/c1-32-12-15(9-17(32)22(36)28-7-5-20(26)27)30-24(38)19-10-16(13-34(19)3)31-23(37)18-8-14(11-33(18)2)29-21(35)4-6-25/h4,6,8-13H,5,7H2,1-3H3,(H3,26,27)(H,28,36)(H,29,35)(H,30,38)(H,31,37)/b6-4-
InChiKey: YUMGXLOODSCLPJ-XQRVVYSFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	matrixin family protein	0.0412	0.0404	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0003	0.0006
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.0016	0.0088
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0007	0.001
Toxoplasma gondii	hypothetical protein	0.0037	0.0018	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0012	0.0027
Schistosoma mansoni	hypothetical protein	0.0035	0.0016	0.003
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0228	0.0215	0.0498
Loa Loa (eye worm)	glutaminase 2	0.4207	0.4312	1
Brugia malayi	MH2 domain containing protein	0.0526	0.0522	0.121
Schistosoma mansoni	ADAMTS5 peptidase (M12 family)	0.0199	0.0184	0.0421
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0013	0.0024
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0037	0.0018	0.0042
Mycobacterium tuberculosis	Possible exported protein	0.1491	0.1515	0.1512
Leishmania major	cathepsin L-like protease	0.0067	0.0048	0.012
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0171	0.0396
Treponema pallidum	polypeptide deformylase (def)	0.9731	1	1
Echinococcus granulosus	adam 17 protease	0.0463	0.0456	0.3124
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0048	0.012
Brugia malayi	peptidase family M13 containing protein	0.0045	0.0026	0.0059
Echinococcus multilocularis	Smad4	0.0036	0.0017	0.0095
Echinococcus multilocularis	disintegrin and metalloproteinase	0.0042	0.0023	0.0138
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0037	0.0018	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0122	0.0283
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0036	0.0017	0.0095
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0048	0.012
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0063	0.0045	0.0104
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0013	0.0073
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0037	0.0018	0.0042
Schistosoma mansoni	sodium/chloride dependent transporter	0.0219	0.0205	0.047
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0219	0.0205	0.0476
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.9731	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0171	0.0396
Brugia malayi	Matrixin family protein	0.0186	0.0171	0.0396
Brugia malayi	latrophilin 2 splice variant baaae	0.0076	0.0057	0.0133
Plasmodium vivax	SET domain protein, putative	0.0033	0.0013	0.0007
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.9731	1	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0037	0.0018	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0205	0.0476
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.016	0.0145	0.0374
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0048	0.012
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0037	0.0018	0.0011
Onchocerca volvulus		0.0186	0.0171	0.4034
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0122	0.0283
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0092	0.0075	0.0167
Trichomonas vaginalis	glutaminase, putative	0.4207	0.4312	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0013	0.0007
Trypanosoma cruzi	major cysteine proteinase, putative	0.0053	0.0034	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0018	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0018	0.0042
Schistosoma mansoni	hypothetical protein	0.0048	0.0029	0.006
Schistosoma mansoni	transcription factor LCR-F1	0.0077	0.0059	0.0131
Schistosoma mansoni	hypothetical protein	0.0048	0.0029	0.006
Plasmodium falciparum	peptide deformylase	0.9731	1	1
Mycobacterium leprae	PROBABLE HYDROLASE	0.0226	0.0212	0.0045
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0048	0.0029	0.0068
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0048	0.012
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0336	0.0326	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0007	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0119	0.0276
Schistosoma mansoni	hypothetical protein	0.0263	0.0251	0.0575
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0048	0.0029	0.006
Onchocerca volvulus		0.0219	0.0205	0.4921
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0135	0.0119	0.0276
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0003	0.0006
Brugia malayi	hypothetical protein	0.0037	0.0018	0.0042
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0037	0.0018	0.0035
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0675	0.0675	0.4632
Loa Loa (eye worm)	matrix metalloproteinase	0.0186	0.0171	0.0396
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0018	0.0011
Loa Loa (eye worm)	MH2 domain-containing protein	0.0526	0.0522	0.121
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0339	0.0329	0.0858
Schistosoma mansoni	neprilysin	0.0048	0.0029	0.006
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0036	0.0017	0.0095
Echinococcus granulosus	endothelin converting enzyme 1	0.0183	0.0168	0.114
Echinococcus multilocularis	microtubule associated protein 2	0.1431	0.1453	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0037	0.0018	0.0042
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0048	0.012
Schistosoma mansoni	sex comb on midleg homolog	0.0056	0.0037	0.0079
Brugia malayi	metalloprotease disintegrin 16 with thrombospondin type I motif	0.0199	0.0184	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0018	0.0042
Schistosoma mansoni	smad1 5 8 and	0.0036	0.0017	0.0032
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0003	0.0006
Mycobacterium ulcerans	hydrolase	0.0226	0.0212	0.021
Brugia malayi	Hemopexin family protein	0.0263	0.0251	0.0581
Schistosoma mansoni	hypothetical protein	0.0048	0.0029	0.006
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0179	0.0163	0.0161
Loa Loa (eye worm)	MBCTL1	0.0063	0.0045	0.0104
Trypanosoma cruzi	Peptide deformylase 2, putative	0.3713	0.3803	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0016	0.0036
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0037	0.0018	0.0104
Loa Loa (eye worm)	glutaminase	0.4207	0.4312	1
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0675	0.0675	0.4632
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0003	0.0006
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0111	0.0093	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0119	0.0276
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0219	0.0205	0.0476
Echinococcus granulosus	tumor protein p63	0.0347	0.0337	0.2301
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0092	0.0075	0.0167
Loa Loa (eye worm)	mbt repeat family protein	0.0056	0.0037	0.0086
Loa Loa (eye worm)	Smad1	0.0036	0.0017	0.0038
Trypanosoma brucei	Peptide deformylase 2	0.3713	0.3803	1
Onchocerca volvulus		0.0037	0.0018	0.0118
Brugia malayi	glutaminase DH11.1	0.4207	0.4312	1
Loa Loa (eye worm)	norepinephrine transporter	0.0219	0.0205	0.0476
Brugia malayi	MH1 domain containing protein	0.0036	0.0017	0.0038
Brugia malayi	Matrixin family protein	0.0186	0.0171	0.0396
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0077	0.0059	0.0388
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.3713	0.3803	1
Trichomonas vaginalis	set domain proteins, putative	0.026	0.0247	0.0567
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.9731	1	1
Echinococcus multilocularis	subfamily M12B unassigned peptidase	0.0042	0.0023	0.0138
Brugia malayi	MH2 domain containing protein	0.0036	0.0017	0.0038
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0412	0.0404	1
Brugia malayi	hypothetical protein	0.0026	0.0007	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0018	0.0042
Leishmania major	cathepsin L-like protease	0.0067	0.0048	0.012
Schistosoma mansoni	cellular tumor antigen P53	0.0051	0.0032	0.0067
Brugia malayi	mbt repeat family protein	0.0056	0.0037	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0212	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0045	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0018	0.0042
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0219	0.0205	0.047
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0013	0.0024
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0037	0.0018	0.0104
Onchocerca volvulus		0.0056	0.0037	0.0605
Echinococcus granulosus	microtubule associated protein 2	0.1431	0.1453	1
Brugia malayi	Matrixin family protein	0.0186	0.0171	0.0396
Echinococcus multilocularis	smad	0.0036	0.0017	0.0095
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0048	0.0029	0.0068
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0012	0.0064
Onchocerca volvulus		0.0037	0.0018	0.0118
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0037	0.0018	0.0042
Onchocerca volvulus		0.0037	0.0018	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0205	0.0476
Schistosoma mansoni	endothelin-converting enzyme-related	0.0045	0.0026	0.0053
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0003	0.5
Trypanosoma brucei	Polypeptide deformylase 1	0.3713	0.3803	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0013	0.0024
Schistosoma mansoni	sodium/chloride dependent transporter	0.0037	0.0018	0.0035
Entamoeba histolytica	hypothetical protein	0.0077	0.0059	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0077	0.0059	0.0388
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0037	0.0018	0.0035
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0007	0.001
Loa Loa (eye worm)	zinc metallopeptidase 4	0.0045	0.0026	0.0059
Schistosoma mansoni	microtubule-associated protein tau	0.1431	0.1453	0.3366
Loa Loa (eye worm)	hypothetical protein	0.0183	0.0168	0.039
Echinococcus granulosus	serotonin transporter	0.0219	0.0205	0.1397
Leishmania major	hypothetical protein, conserved	0.0026	0.0007	0.001
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.0016	0.0088
Loa Loa (eye worm)	transcription factor SMAD2	0.0526	0.0522	0.121
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0037	0.0018	0.0042
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0048	0.0029	0.0068
Echinococcus granulosus	GPCR family 2	0.0035	0.0016	0.0088
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0045	0.0026	0.0053
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.3713	0.3803	1
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0144	0.0127	0.0289
Mycobacterium ulcerans	zinc metalloprotease	0.0183	0.0168	0.0165
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0135	0.0119	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0122	0.0283
Brugia malayi	hypothetical protein	0.0073	0.0055	0.0127
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.016	0.0145	0.0374
Loa Loa (eye worm)	MH2 domain-containing protein	0.0036	0.0017	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0037	0.0086
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0063	0.0045	0.029
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.0045	0.0026	0.0053
Schistosoma mansoni	hypothetical protein	0.0048	0.0029	0.006
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0122	0.0283
Schistosoma mansoni	glutaminase	0.4207	0.4312	1
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0045	0.0026	0.0053
Echinococcus granulosus	smad	0.0036	0.0017	0.0095
Echinococcus granulosus	SAM and MBT domain containing protein	0.0056	0.0037	0.0235
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0013	0.0073
Toxoplasma gondii	peptidase family M13 protein	0.0183	0.0168	0.0162
Brugia malayi	ADAM-TS Spacer 1 family protein	0.0031	0.0012	0.0027
Schistosoma mansoni	dihydroceramide desaturase	0.0042	0.0023	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0122	0.0283
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0037	0.0018	0.0035
Schistosoma mansoni	ADAM17 peptidase (M12 family)	0.0421	0.0413	0.0951
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0037	0.0018	0.0011
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0339	0.0329	0.0858
Echinococcus granulosus	sodium and chloride dependent glycine	0.0037	0.0018	0.0104
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0183	0.0168	0.0165
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0048	0.012
Schistosoma mansoni	hypothetical protein	0.0048	0.0029	0.006
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0061	0.0042	0.0104
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0045	0.0026	0.0053
Schistosoma mansoni	hypothetical protein	0.0076	0.0057	0.0127
Echinococcus granulosus	histone acetyltransferase MYST2	0.0063	0.0045	0.029
Echinococcus granulosus	Smad4	0.0036	0.0017	0.0095
Schistosoma mansoni	hypothetical protein	0.0035	0.0016	0.003
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0056	0.0037	0.0079
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0183	0.0168	0.039
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0048	0.012
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0063	0.0045	0.029
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.0016	0.0088
Onchocerca volvulus		0.0051	0.0032	0.0475
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0056	0.0037	0.0605
Entamoeba histolytica	hypothetical protein	0.0077	0.0059	1
Onchocerca volvulus	Matrilysin homolog	0.0412	0.0404	1
Leishmania major	mitochondrial DNA polymerase beta	0.0339	0.0329	0.0858
Echinococcus multilocularis	serotonin transporter	0.0219	0.0205	0.1397
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0042	0.0023	0.0046
Plasmodium vivax	peptide deformylase, putative	0.9731	1	1
Leishmania major	cathepsin L-like protease	0.0067	0.0048	0.012
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0037	0.0018	0.0104
Onchocerca volvulus		0.0263	0.0251	0.6081
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.016	0.0145	0.0374
Echinococcus granulosus	sodium and chloride dependent glycine	0.0037	0.0018	0.0104
Toxoplasma gondii	hypothetical protein	0.9731	1	1
Echinococcus granulosus	disintegrin and metalloproteinase	0.0042	0.0023	0.0138
Echinococcus multilocularis	adam	0.0073	0.0055	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0205	0.0476
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0037	0.0018	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0183	0.0168	0.039
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0048	0.012
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0007	0.001
Brugia malayi	MH2 domain containing protein	0.0036	0.0017	0.0038
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0336	0.0326	0.0323
Echinococcus granulosus	subfamily M12B unassigned peptidase	0.0042	0.0023	0.0138
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0037	0.0018	0.0035
Echinococcus multilocularis	adam 17 protease	0.0421	0.0413	0.2826
Schistosoma mansoni	sex comb on midleg homolog	0.0056	0.0037	0.0079
Schistosoma mansoni	smad	0.0036	0.0017	0.0032
Plasmodium falciparum	transporter, putative	0.0037	0.0018	0.0011
Brugia malayi	Matrixin family protein	0.0186	0.0171	0.0396
Brugia malayi	Pre-SET motif family protein	0.0033	0.0013	0.0031
Mycobacterium ulcerans	peptide deformylase	0.9731	1	1
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0219	0.0206	0.1398
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0037	0.0018	0.0104
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.0016	0.0088
Echinococcus granulosus	a disintegrin and metalloproteinase with	0.0199	0.0184	0.125
Schistosoma mansoni	hypothetical protein	0.0077	0.0059	0.0131
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0048	0.012
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0111	0.0093	0.0217
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0016	0.0036
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0048	0.012
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0119	0.0276
Mycobacterium ulcerans	glutaminase	0.4207	0.4312	0.431
Brugia malayi	MH1 domain containing protein	0.0036	0.0017	0.0038
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0036	0.0017	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0122	0.0283
Echinococcus granulosus	polycomb protein SCMH1	0.0056	0.0037	0.0235
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0016	0.0036
Toxoplasma gondii	hypothetical protein	0.0037	0.0018	0.0011
Loa Loa (eye worm)	MH1 domain-containing protein	0.0036	0.0017	0.0038
Plasmodium falciparum	amino acid transporter, putative	0.0037	0.0018	0.0011
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0042	0.0023	0.0046
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0048	0.012
Schistosoma mansoni	Smad4	0.0036	0.0017	0.0032
Trypanosoma cruzi	cruzipain precursor, putative	0.0067	0.0048	0.012
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0058	0.0039	0.0096
Loa Loa (eye worm)	serotonin transporter b	0.0219	0.0205	0.0476
Echinococcus multilocularis	tumor protein p63	0.0347	0.0337	0.2301
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0037	0.0018	0.0042
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0037	0.0018	0.0104
Echinococcus multilocularis	polycomb protein SCMH1	0.0056	0.0037	0.0235
Mycobacterium ulcerans	hypothetical protein	0.0179	0.0163	0.0161
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0056	0.0037	0.0235
Brugia malayi	mbt repeat family protein	0.0056	0.0037	0.0086
Loa Loa (eye worm)	reprolysin	0.0042	0.0023	0.0053
Echinococcus granulosus	adam	0.0073	0.0055	0.0359
Brugia malayi	Smad1	0.0036	0.0017	0.0038
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0037	0.0018	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0013	0.0031
Entamoeba histolytica	hypothetical protein	0.0077	0.0059	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0032	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0093	0.0217
Trypanosoma cruzi	Peptide deformylase 2, putative	0.3713	0.3803	1
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0219	0.0206	0.1398
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0092	0.0075	0.0167
Echinococcus granulosus	mothers against decapentaplegic 5	0.0036	0.0017	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0884	0.089	0.2063
Schistosoma mansoni	sodium/chloride dependent transporter	0.0037	0.0018	0.0035
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0048	0.012
Brugia malayi	Disintegrin family protein	0.0042	0.0023	0.0053
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0226	0.0212	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0119	0.0276
Brugia malayi	Pre-SET motif family protein	0.0228	0.0215	0.0498
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0045	0.0026	0.0053
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0036	0.0017	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0073	0.0169
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0013	0.0073
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0092	0.0075	0.0167
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0048	0.012
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0339	0.0329	0.0858
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0063	0.0045	0.0098
Leishmania major	polypeptide deformylase-like protein, putative	0.3713	0.3803	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0013	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0018	0.0042
Plasmodium vivax	amine transporter, putative	0.0037	0.0018	0.0011
Brugia malayi	Matrixin family protein	0.0449	0.0442	0.1025
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0012	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0023	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0018	0.0042
Schistosoma mansoni	hypothetical protein	0.0339	0.0328	0.0755
Echinococcus multilocularis	a disintegrin and metalloproteinase with	0.0199	0.0184	0.125
Brugia malayi	ADAMTS-like protease	0.0031	0.0012	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0016	0.0036
Onchocerca volvulus		0.026	0.0247	0.5993
Echinococcus multilocularis	Blood coagulation inhibitor, Disintegrin	0.0264	0.0251	0.1714
Onchocerca volvulus		0.0091	0.0073	0.153
Schistosoma mansoni	smad1 5 8 and	0.0036	0.0017	0.0032
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0037	0.0018	0.0104
Brugia malayi	angiogenesis inhibito	0.0031	0.0012	0.0027
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0183	0.0168	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0057	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0183	0.0168	0.039
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0171	0.0396
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0092	0.0075	0.0167
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0063	0.0045	0.029
Schistosoma mansoni	hypothetical protein	0.0048	0.0029	0.006
Schistosoma mansoni	hypothetical protein	0.0035	0.0016	0.003
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0186	0.0171	0.039
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0037	0.0018	0.0035
Echinococcus multilocularis	GPCR, family 2	0.0035	0.0016	0.0088
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0037	0.0018	0.0104
Brugia malayi	hypothetical protein	0.0077	0.0059	0.0137
Schistosoma mansoni	adam (A disintegrin and metalloprotease	0.0073	0.0055	0.0121
Schistosoma mansoni	hypothetical protein	0.0035	0.0016	0.003
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0037	0.0018	0.0035
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0037	0.0018	0.0104
Echinococcus multilocularis	endothelin converting enzyme 1	0.0183	0.0168	0.114
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0037	0.0018	0.0104
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0226	0.0212	0.021
Schistosoma mansoni	smad1 5 8 and	0.0036	0.0017	0.0032
Loa Loa (eye worm)	matrixin family protein	0.0449	0.0442	0.1025
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0012	0.0027
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0048	0.012
Onchocerca volvulus	Matrilysin homolog	0.0186	0.0171	0.4034
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0111	0.0093	0.0217
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0048	0.0029	0.0068
Entamoeba histolytica	hypothetical protein	0.0077	0.0059	1
Brugia malayi	Peptidase family M13 containing protein	0.0183	0.0168	0.039
Toxoplasma gondii	hypothetical protein	0.0055	0.0036	0.0029
Echinococcus granulosus	Blood coagulation inhibitor Disintegrin	0.0264	0.0251	0.1714

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2110020

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1689496