TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 449.547 | Formula: C19H23N5O4S2
H donors: 2 H acceptors: 5 LogP: 1.66 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCCNC(=O)CSc1nnc(s1)NC(=O)C1CC(=O)N(C1)c1ccccc1OC
InChi: 1S/C19H23N5O4S2/c1-3-8-20-15(25)11-29-19-23-22-18(30-19)21-17(27)12-9-16(26)24(10-12)13-6-4-5-7-14(13)28-2/h4-7,12H,3,8-11H2,1-2H3,(H,20,25)(H,21,22,27)
InChiKey: IBMJTXIGSXOSKE-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	histamine h1 receptor	0.0198	0.0298	0.0298
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0055	0.0073	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0198	0.0298	0.0298
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0198	0.0298	0.0298
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0055	0.0073	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.0035	0.2051
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0012	0.1387
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.0002
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0198	0.0298	0.0298
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0017	0.0014	0.0014
Brugia malayi	CHE-14 protein	0.0036	0.0043	0.0043
Mycobacterium ulcerans	acyl-CoA synthetase	0.0016	0.0012	0.1387
Onchocerca volvulus		0.001	0.0002	0.0002
Echinococcus granulosus	cathepsin b	0.0092	0.0132	0.0132
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0035	0.2013
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.1092	0.1706	0.1706
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0051	0.0051
Brugia malayi	Trypsin family protein	0.0024	0.0025	0.0024
Brugia malayi	Sugar transporter family protein	0.007	0.0097	0.0097
Echinococcus granulosus	glycoprotein Antigen 5	0.0024	0.0025	0.0025
Brugia malayi	AMP-binding enzyme family protein	0.0055	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0021	0.002
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0198	0.0298	0.0298
Echinococcus multilocularis	allatostatin A receptor	0.0198	0.0298	0.0298
Brugia malayi	hypothetical protein	0.0012	0.0006	0.0006
Plasmodium vivax	sugar transporter, putative	0.001	0.0002	0.0005
Echinococcus multilocularis	fmrfamide receptor	0.0198	0.0298	0.0298
Onchocerca volvulus		0.0031	0.0035	0.0035
Echinococcus granulosus	g protein coupled receptor	0.0198	0.0298	0.0298
Plasmodium falciparum	transporter, putative	0.1092	0.1706	1
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0014	0.0111
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0036	0.0043	0.0043
Trypanosoma cruzi	hexose transporter, putative	0.0012	0.0005	0.0241
Schistosoma mansoni	cercarial elastase (S01 family)	0.0024	0.0025	0.0025
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0016	0.0012	0.1387
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0055	0.0073	1
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0114	0.0166	0.0166
Brugia malayi	Papain family cysteine protease containing protein	0.0031	0.0035	0.0035
Echinococcus multilocularis	serotonin receptor	0.0198	0.0298	0.0298
Giardia lamblia	Cathepsin B precursor	0.0034	0.004	0.2303
Entamoeba histolytica	hypothetical protein	0.0055	0.0074	0.4004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0051	0.0051
Echinococcus multilocularis	cysteine protease	0.0031	0.0035	0.0035
Loa Loa (eye worm)	cathepsin B	0.0034	0.004	0.004
Onchocerca volvulus	Cathepsin L homolog	0.0031	0.0035	0.0035
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1307	0.2044	0.2044
Leishmania major	cathepsin L-like protease	0.0031	0.0035	0.2013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0031	0.0035	0.2013
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.0002
Brugia malayi	Sugar transporter family protein	0.001	0.0002	0.0002
Schistosoma mansoni	neuropeptide f receptor 76f	0.0198	0.0298	0.0298
Trypanosoma cruzi	glucose transporter, putative	0.001	0.0002	0.0048
Schistosoma mansoni	hypothetical protein	0.0034	0.0041	0.0041
Echinococcus multilocularis	neuropeptide Y receptor	0.0198	0.0298	0.0298
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0114	0.0166	1
Leishmania major	glucose transporter, lmgt2	0.0022	0.0021	0.1136
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Mycobacterium ulcerans	acyl-CoA synthetase	0.0016	0.0012	0.1387
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Echinococcus multilocularis	neuropeptide receptor	0.0198	0.0298	0.0298
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0014	0.0111
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0198	0.0298	0.0298
Trypanosoma brucei	glucose transporter, putative	0.0022	0.0021	0.1136
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0014	0.0111
Brugia malayi	Serotonin receptor	0.0198	0.0298	0.0298
Brugia malayi	hypothetical protein	0.001	0.0002	0.0002
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0016	0.0012	0.0596
Onchocerca volvulus		0.001	0.0002	0.0002
Onchocerca volvulus		0.001	0.0002	0.0002
Trichomonas vaginalis	glucose transporter, putative	0.0022	0.0021	0.1136
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0055	0.0073	1
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0014	0.0111
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0016	0.0012	0.0057
Schistosoma mansoni	survival motor neuron protein	0.0041	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0203	0.0307	0.0307
Schistosoma mansoni	hypothetical protein	0.0034	0.0041	0.0041
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0016	0.0012	0.0012
Schistosoma mansoni	hypothetical protein	0.005	0.0066	0.0066
Schistosoma mansoni	cathepsin F (C01 family)	0.0031	0.0035	0.0035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0035	0.2013
Brugia malayi	GnHR receptor homolog	0.0198	0.0298	0.0298
Loa Loa (eye worm)	trypsin family protein	0.0024	0.0025	0.0024
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.1092	0.1706	0.1706
Loa Loa (eye worm)	hypothetical protein	0.005	0.0066	0.0066
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0016	0.0012	0.0057
Echinococcus multilocularis	g-protein coupled receptor	0.0198	0.0298	0.0298
Mycobacterium ulcerans	acyl-CoA synthetase	0.0055	0.0073	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0016	0.0012	0.1387
Echinococcus multilocularis	dnaJ subfamily B	0.0352	0.054	0.054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0092	0.0132	0.0132
Entamoeba histolytica	acyl-coA synthetase, putative	0.0055	0.0073	0.3936
Leishmania major	cathepsin L-like protease	0.0031	0.0035	0.2013
Mycobacterium ulcerans	acyl-CoA synthetase	0.0055	0.0073	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0055	0.0073	0.3936
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.0176	0.0176
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0012	0.1387
Brugia malayi	AMP-binding enzyme family protein	0.0016	0.0012	0.0012
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0024	0.0025	0.0025
Echinococcus multilocularis	Mastin	0.0024	0.0025	0.0025
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.007	0.0097	0.0097
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0021	0.002
Echinococcus granulosus	g protein coupled receptor	0.0198	0.0298	0.0298
Plasmodium vivax	acyl-CoA synthetase, putative	0.0041	0.0051	0.0291
Onchocerca volvulus		0.0016	0.0012	0.0012
Trypanosoma brucei	polo-like protein kinase	0.0114	0.0166	1
Brugia malayi	Serotonin receptor	0.0198	0.0298	0.0298
Leishmania major	hypothetical protein, conserved	0.0019	0.0016	0.0849
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0034	0.004	0.004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0035	0.2013
Onchocerca volvulus		0.001	0.0002	0.0002
Echinococcus granulosus	cysteine protease	0.0017	0.0014	0.0014
Schistosoma mansoni	hypothetical protein	0.0109	0.0158	0.0158
Leishmania major	cathepsin L-like protease	0.0031	0.0035	0.2013
Schistosoma mansoni	cercarial elastase (S01 family)	0.0024	0.0025	0.0025
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0014	0.0111
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0114	0.0166	1
Echinococcus multilocularis	protein patched	0.0036	0.0043	0.0043
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.0035	0.2051
Brugia malayi	Major Facilitator Superfamily protein	0.001	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.6363	1	1
Schistosoma mansoni	sodium-dependent amino acid transporter	0.1092	0.1706	0.1706
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0031	0.0035	0.0035
Schistosoma mansoni	neuropeptide receptor	0.0198	0.0298	0.0298
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0159	0.0237	0.0237
Entamoeba histolytica	hypothetical protein	0.0055	0.0074	0.4004
Onchocerca volvulus		0.0025	0.0026	0.0025
Brugia malayi	hypothetical protein	0.1092	0.1706	0.1706
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0024	0.0025	0.0025
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0055	0.0073	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0083	0.0118	0.685
Plasmodium vivax	ataxin-2 like protein, putative	0.0019	0.0016	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0118	0.0117
Trypanosoma brucei	PAB1-binding protein , putative	0.0019	0.0016	0.0849
Loa Loa (eye worm)	cysteine protease	0.0031	0.0035	0.0035
Schistosoma mansoni	neuropeptide receptor	0.0198	0.0298	0.0298
Brugia malayi	follicle stimulating hormone receptor	0.0198	0.0298	0.0298
Echinococcus multilocularis	serotonin transporter	0.6363	1	1
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Onchocerca volvulus		0.0198	0.0298	0.0298
Schistosoma mansoni	hypothetical protein	0.0034	0.0041	0.0041
Echinococcus granulosus	rhodopsin orphan GPCR	0.0198	0.0298	0.0298
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0198	0.0298	0.0298
Echinococcus multilocularis	neuropeptide receptor A26	0.0198	0.0298	0.0298
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0084	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0001	0.0001
Trypanosoma cruzi	hexose transporter, putative	0.0022	0.0021	0.1178
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0035	0.0035
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0031	0.0035	0.0194
Loa Loa (eye worm)	serotonin transporter b	0.6363	1	1
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0014	0.0111
Schistosoma mansoni	glucose transport protein	0.007	0.0097	0.0097
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0198	0.0298	0.0298
Echinococcus granulosus	serotonin receptor	0.0198	0.0298	0.0298
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.007	0.0097	0.0097
Onchocerca volvulus		0.001	0.0002	0.0002
Schistosoma mansoni	acetyl-CoA synthetase	0.0016	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0166	1
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0097	0.5759
Onchocerca volvulus		0.0198	0.0298	0.0298
Schistosoma mansoni	cercarial elastase (S01 family)	0.0024	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.0198	0.0298	0.0298
Plasmodium vivax	hypothetical protein, conserved	0.1092	0.1706	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0016	0.0012	0.0012
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0055	0.0073	1
Onchocerca volvulus		0.001	0.0002	0.0002
Trypanosoma cruzi	PAB1-binding protein , putative	0.0019	0.0016	0.0892
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0198	0.0298	0.0298
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0039	0.0048	0.0048
Echinococcus granulosus	serotonin transporter	0.6363	1	1
Loa Loa (eye worm)	hypothetical protein	0.6363	1	1
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Mycobacterium ulcerans	hypothetical protein	0.0055	0.0073	1
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0016	0.0012	0.1387
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0198	0.0298	0.0298
Echinococcus granulosus	neuropeptide receptor A26	0.0198	0.0298	0.0298
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0014	0.0111
Trichomonas vaginalis	sugar transporter, putative	0.0022	0.0021	0.1136
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.007	0.0097	0.0097
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.1092	0.1706	0.1706
Trypanosoma brucei	glucose transporter, putative	0.0022	0.0021	0.1136
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0073	0.0073
Onchocerca volvulus		0.0198	0.0298	0.0298
Schistosoma mansoni	opsin-like receptor	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0073	0.0073
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0016	0.0012	0.0012
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0039	0.0048	0.0048
Echinococcus granulosus	Niemann Pick C1 protein	0.0119	0.0174	0.0174
Toxoplasma gondii	propionate-CoA ligase	0.0016	0.0012	0.0057
Loa Loa (eye worm)	norepinephrine transporter	0.6363	1	1
Echinococcus multilocularis	muscleblind protein 1	0.015	0.0223	0.0223
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0024	0.0025	0.0025
Echinococcus multilocularis	glycoprotein Antigen 5	0.0024	0.0025	0.0025
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0035	0.2013
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0017	0.0014	0.0014
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0198	0.0298	0.0298
Schistosoma mansoni	growth hormone secretagogue receptor	0.0198	0.0298	0.0298
Echinococcus multilocularis	solute carrier family 22	0.001	0.0002	0.0002
Echinococcus granulosus	g-protein coupled receptor	0.0198	0.0298	0.0298
Echinococcus granulosus	rhodopsin orphan GPCR	0.0198	0.0298	0.0298
Onchocerca volvulus		0.001	0.0002	0.0002
Trypanosoma brucei	glucose transporter, putative	0.0022	0.0021	0.1136
Onchocerca volvulus		0.0016	0.0012	0.0012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0035	0.2013
Trichomonas vaginalis	sugar transporter, putative	0.0022	0.0021	0.1136
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0198	0.0298	0.0298
Echinococcus multilocularis	neuropeptides capa receptor	0.0198	0.0298	0.0298
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.1092	0.1706	0.1706
Plasmodium vivax	unspecified product	0.0017	0.0014	0.0072
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.1092	0.1706	1
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0014	0.0111
Onchocerca volvulus		0.0198	0.0298	0.0298
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0024	0.0025	0.0025
Leishmania major	cathepsin L-like protease	0.0031	0.0035	0.2013
Loa Loa (eye worm)	melatonin receptor type 1A	0.0198	0.0298	0.0298
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0009	0.0001	0.0001
Brugia malayi	neuropeptide F receptor	0.0198	0.0298	0.0298
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.1092	0.1706	0.1706
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.0002
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0043	0.2482
Brugia malayi	AMP-binding enzyme family protein	0.0016	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0021	0.1136
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0035	0.2013
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0016	0.0012	0.1387
Echinococcus multilocularis	solute carrier family 22	0.001	0.0002	0.0002
Leishmania major	4-coumarate:coa ligase-like protein	0.0055	0.0073	0.4298
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0198	0.0298	0.0298
Schistosoma mansoni	cercarial elastase (S01 family)	0.0024	0.0025	0.0025
Schistosoma mansoni	amine GPCR	0.0198	0.0298	0.0298
Loa Loa (eye worm)	major facilitator superfamily transporter	0.001	0.0002	0.0002
Brugia malayi	Trypsin family protein	0.0024	0.0025	0.0024
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.005	0.0066	0.0066
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.005	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Mycobacterium ulcerans	acyl-CoA synthetase	0.0055	0.0073	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0159	0.0237	0.0237
Schistosoma mansoni	sodium/chloride dependent transporter	0.6363	1	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0022	0.0021	0.1136
Echinococcus granulosus	solute carrier family 22	0.001	0.0002	0.0002
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0055	0.0073	0.3936
Echinococcus granulosus	hypothetical protein	0.0198	0.0298	0.0298
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0039	0.0048	0.0048
Schistosoma mansoni	opsin-like receptor	0.0198	0.0298	0.0298
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0166	1
Schistosoma mansoni	amine GPCR	0.0198	0.0298	0.0298
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.1092	0.1706	0.1706
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0001	0.0001
Trichomonas vaginalis	sugar transporter, putative	0.0022	0.0021	0.1136
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.1092	0.1706	0.1706
Echinococcus multilocularis	Niemann Pick C1 protein	0.0119	0.0174	0.0174
Schistosoma mansoni	cercarial elastase (S01 family)	0.0024	0.0025	0.0025
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0017	0.0014	0.0014
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0092	0.0132	0.0132
Echinococcus granulosus	neuropeptides capa receptor	0.0198	0.0298	0.0298
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.6363	1	1
Brugia malayi	Trypsin family protein	0.0024	0.0025	0.0024
Echinococcus multilocularis	Niemann Pick C1 protein	0.0083	0.0118	0.0118
Brugia malayi	Cathepsin L-like precursor	0.0009	0.0001	0.0001
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0166	1
Brugia malayi	hypothetical protein	0.0055	0.0074	0.0074
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0035	0.2013
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0024	0.0025	0.0025
Onchocerca volvulus	Cathepsin L homolog	0.0031	0.0035	0.0035
Echinococcus granulosus	sodium and chloride dependent glycine	0.1153	0.1801	0.1801
Onchocerca volvulus		0.0031	0.0035	0.0035
Entamoeba histolytica	cysteine proteinase 1, putative	0.0017	0.0014	0.0111
Onchocerca volvulus		0.0016	0.0012	0.0012
Onchocerca volvulus		0.0058	0.0078	0.0078
Onchocerca volvulus		0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Onchocerca volvulus		0.001	0.0002	0.0002
Trypanosoma cruzi	hexose transporter	0.0022	0.0021	0.1178
Brugia malayi	hypothetical protein	0.001	0.0002	0.0002
Echinococcus granulosus	biogenic amine 5HT receptor	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.0002
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0016	0.0012	0.1387
Echinococcus granulosus	Niemann Pick C1 protein	0.0083	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0051	0.0051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0035	0.2013
Brugia malayi	Dopamine receptor protein 2	0.0198	0.0298	0.0298
Plasmodium vivax	amine transporter, putative	0.1092	0.1706	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0001	0.0001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0021	0.1118
Leishmania major	glucose transporter, lmgt1	0.0022	0.0021	0.1136
Leishmania major	cathepsin L-like protease	0.0031	0.0035	0.2013
Schistosoma mansoni	sugar transporter	0.001	0.0002	0.0002
Echinococcus granulosus	tm gpcr rhodopsin	0.0198	0.0298	0.0298
Echinococcus granulosus	neuropeptide s receptor	0.0198	0.0298	0.0298
Brugia malayi	putative neuropeptide receptor	0.0198	0.0298	0.0298
Plasmodium vivax	vivapain-2	0.0031	0.0035	0.0198
Onchocerca volvulus		0.0198	0.0298	0.0298
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0034	0.004	0.2303
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0016	0.0012	0.1387
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.1092	0.1706	0.1706
Echinococcus granulosus	cathepsin b	0.0092	0.0132	0.0132
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0093	0.0093
Brugia malayi	hypothetical protein	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.0002
Brugia malayi	Sugar transporter family protein	0.001	0.0002	0.0002
Echinococcus multilocularis	g protein coupled receptor	0.0198	0.0298	0.0298
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0198	0.0298	0.0298
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0016	0.0012	0.0596
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0014	0.0111
Echinococcus multilocularis	protein dispatched 1	0.0041	0.0051	0.0051
Mycobacterium ulcerans	acyl-CoA synthetase	0.0016	0.0012	0.1387
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0159	0.0237	0.0237
Plasmodium vivax	vivapain-2	0.0031	0.0035	0.0198
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0035	0.2013
Schistosoma mansoni	neuropeptide F-like receptor	0.0198	0.0298	0.0298
Brugia malayi	major facilitator superfamily protein	0.001	0.0002	0.0002
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0198	0.0298	0.0298
Echinococcus multilocularis	neuropeptide s receptor	0.0198	0.0298	0.0298
Schistosoma mansoni	cercarial elastase (S01 family)	0.0024	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.005	0.0066	0.0066
Schistosoma mansoni	neuropeptide F-like receptor	0.0198	0.0298	0.0298
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0198	0.0298	0.0298
Schistosoma mansoni	hypothetical protein	0.0352	0.054	0.054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0035	0.2013
Brugia malayi	AMP-binding enzyme family protein	0.0016	0.0012	0.0012
Schistosoma mansoni	opsin-like receptor	0.0198	0.0298	0.0298
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0055	0.0074	0.0074
Schistosoma mansoni	sugar transporter	0.001	0.0002	0.0002
Trypanosoma brucei	glucose transporter, putative	0.0022	0.0021	0.1136
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0198	0.0298	0.0298
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0014	0.0111
Echinococcus multilocularis	cathepsin L cysteine protease	0.0031	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.0002
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0034	0.004	0.234
Echinococcus granulosus	rhodopsin orphan GPCR	0.0198	0.0298	0.0298
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0016	0.0012	0.1387
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0014	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0021	0.002
Trypanosoma cruzi	cysteine protease, putative	0.0017	0.0014	0.0745
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0024	0.0025	0.0025
Brugia malayi	Trypsin family protein	0.0082	0.0116	0.0116
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.005	0.0066	0.0066
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0198	0.0298	0.0298
Echinococcus granulosus	sodium and chloride dependent glycine	0.1153	0.1801	0.1801
Trypanosoma brucei	glucose transporter, putative	0.0022	0.0021	0.1136
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0198	0.0298	0.0298
Toxoplasma gondii	cathepsin CPL	0.0031	0.0035	0.0194
Echinococcus granulosus	fmrfamide receptor	0.0198	0.0298	0.0298
Echinococcus multilocularis	neuropeptide receptor	0.0198	0.0298	0.0298
Brugia malayi	major facilitator superfamily protein	0.001	0.0002	0.0002
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0035	0.1506
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.0002
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0198	0.0298	0.0298
Trypanosoma cruzi	hexose transporter, putative	0.0022	0.0021	0.1178
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0016	0.0012	0.1387
Echinococcus granulosus	rhodopsin orphan GPCR	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Brugia malayi	Muscleblind-like protein	0.015	0.0223	0.0223
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0039	0.0048	0.642
Loa Loa (eye worm)	sugar transporter	0.007	0.0097	0.0097
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0012	0.1387
Schistosoma mansoni	sugar transporter	0.001	0.0002	0.0002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0198	0.0298	0.0298
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0198	0.0298	0.0298
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0198	0.0298	0.0298
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.1092	0.1706	0.1706
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0092	0.0132	0.7888
Trypanosoma brucei	glucose transporter, putative	0.0022	0.0021	0.1136
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0052	0.0069	0.0069
Leishmania major	cathepsin L-like protease	0.0031	0.0035	0.2013
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0035	0.0035
Brugia malayi	cathepsin B-like cysteine proteinase	0.0092	0.0132	0.0131
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.1092	0.1706	0.1706
Leishmania major	acetyl-CoA synthetase, putative	0.0016	0.0012	0.0596
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0041	0.0051	0.6918
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0035	0.2013
Brugia malayi	hypothetical protein	0.0203	0.0307	0.0307
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.0176	0.0176
Loa Loa (eye worm)	neuropeptide F receptor	0.0198	0.0298	0.0298
Echinococcus multilocularis	cathepsin b	0.0092	0.0132	0.0132
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0031	0.0035	0.0035
Leishmania major	acetyl-CoA synthetase, putative	0.0016	0.0012	0.0596
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0031	0.0035	0.2013
Trichomonas vaginalis	glucose transporter, putative	0.0022	0.0021	0.1136
Giardia lamblia	Cathepsin B precursor	0.0034	0.004	0.2303
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0035	0.2013
Brugia malayi	Niemann-Pick C1 protein precursor	0.0083	0.0118	0.0117
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0024	0.0025	0.0025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0035	0.2013
Echinococcus granulosus	neuropeptide FF receptor 2	0.0198	0.0298	0.0298
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.0035	0.2051
Schistosoma mansoni	cathepsin s	0.0009	0.0001	0.0001
Brugia malayi	latrophilin 2 splice variant baaae	0.0109	0.0158	0.0157
Leishmania major	glucose transporter, lmgt3	0.0022	0.0021	0.1136
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0198	0.0298	0.0298
Brugia malayi	hypothetical protein	0.0198	0.0298	0.0298
Schistosoma mansoni	hypothetical protein	0.0041	0.0052	0.0052
Onchocerca volvulus		0.0031	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0043	0.0043
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0082	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Onchocerca volvulus		0.0031	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.0002
Echinococcus multilocularis	cathepsin L	0.0017	0.0014	0.0014
Echinococcus granulosus	neuropeptide Y receptor	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0198	0.0298	0.0298
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0014	0.0014
Schistosoma mansoni	neuropeptide receptor	0.0198	0.0298	0.0298
Onchocerca volvulus		0.0031	0.0035	0.0035
Schistosoma mansoni	hypothetical protein	0.005	0.0066	0.0066
Brugia malayi	hypothetical protein	0.0198	0.0298	0.0298
Leishmania major	4-coumarate:coa ligase-like protein	0.0055	0.0073	0.4298
Brugia malayi	ORL1-like opioid receptor	0.0198	0.0298	0.0298
Echinococcus granulosus	g protein coupled receptor	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0073	0.0073
Echinococcus granulosus	survival motor neuron protein 1	0.0203	0.0307	0.0307
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0114	0.0166	0.0166
Schistosoma mansoni	hypothetical protein	0.0198	0.0298	0.0298
Echinococcus granulosus	cathepsin l1	0.0031	0.0035	0.0035
Trypanosoma cruzi	sugar transporter, putative	0.001	0.0002	0.0048
Leishmania major	cathepsin L-like protease	0.0031	0.0035	0.2013
Echinococcus multilocularis	cathepsin L cysteine protease	0.0031	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.015	0.0223	0.0223
Schistosoma mansoni	glucose transport protein	0.007	0.0097	0.0097
Schistosoma mansoni	amine GPCR	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0158	0.0157
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.007	0.0097	0.0097
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.007	0.0097	0.0097
Plasmodium falciparum	amino acid transporter, putative	0.1092	0.1706	1
Schistosoma mansoni	amine GPCR	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0024	0.0025	0.0025
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0198	0.0298	0.0298
Schistosoma mansoni	serine/threonine protein kinase	0.0114	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Loa Loa (eye worm)	TYRA-2 protein	0.0198	0.0298	0.0298
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0014	0.0111
Echinococcus granulosus	allatostatin A receptor	0.0198	0.0298	0.0298
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.0076	0.4474
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0014	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Onchocerca volvulus		0.6363	1	1
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0016	0.0012	0.1387
Leishmania major	4-coumarate:coa ligase-like protein	0.0055	0.0073	0.4298
Trypanosoma brucei	glucose transporter, putative	0.0022	0.0021	0.1136
Giardia lamblia	Cathepsin B precursor	0.0034	0.004	0.2303
Echinococcus multilocularis	transmembrane protease serine 3	0.0024	0.0025	0.0025
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0021	0.002
Onchocerca volvulus		0.001	0.0002	0.0002
Onchocerca volvulus		0.001	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Echinococcus granulosus	sterol regulatory element binding protein	0.0036	0.0043	0.0043
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0041	0.0052	0.0052
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0198	0.0298	0.0298
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0092	0.0132	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0021	0.002
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0198	0.0298	0.0298
Brugia malayi	hypothetical protein	0.0198	0.0298	0.0298
Plasmodium falciparum	acyl-CoA synthetase	0.0041	0.0051	0.0286
Echinococcus multilocularis	solute carrier family 22	0.001	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.0002
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0016	0.0012	0.1387
Echinococcus multilocularis	enteropeptidase	0.0024	0.0025	0.0025
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0016	0.0012	0.0057
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0198	0.0298	0.0298
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0024	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0014	0.0111
Mycobacterium ulcerans	acyl-CoA synthetase	0.0016	0.0012	0.1387
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0198	0.0298	0.0298
Echinococcus granulosus	dnaJ subfamily B	0.0352	0.054	0.054
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0025	0.0024
Onchocerca volvulus		0.1092	0.1706	0.1706
Brugia malayi	neuropeptide F receptor	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.1092	0.1706	0.1706
Schistosoma mansoni	sodium/chloride dependent transporter	0.1153	0.1802	0.1802
Trypanosoma brucei	glucose transporter, putative	0.0022	0.0021	0.1136
Echinococcus multilocularis	cathepsin b	0.0092	0.0132	0.0132
Echinococcus granulosus	biogenic amine 5HT receptor	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.1092	0.1706	1
Schistosoma mansoni	patched 1	0.0036	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Echinococcus multilocularis	survival motor neuron protein 1	0.0203	0.0307	0.0307
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.005	0.0066	0.0066
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0034	0.004	0.2303
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0035	0.2013
Mycobacterium ulcerans	acyl-CoA synthetase	0.0016	0.0012	0.1387
Onchocerca volvulus		0.0024	0.0025	0.0024
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0031	0.0035	0.0194
Schistosoma mansoni	cercarial elastase (S01 family)	0.0024	0.0025	0.0025
Loa Loa (eye worm)	neuropeptide F receptor	0.0198	0.0298	0.0298
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0014	0.0111
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0035	0.2013
Echinococcus granulosus	enteropeptidase	0.0024	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0025	0.0024
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0198	0.0298	0.0298
Brugia malayi	hypothetical protein	0.0198	0.0298	0.0298
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0014	0.0111
Onchocerca volvulus		0.0198	0.0298	0.0298
Brugia malayi	G-protein coupled receptor	0.0198	0.0298	0.0298
Brugia malayi	Trypsin-like protease protein 5	0.0024	0.0025	0.0024
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0031	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0198	0.0298	0.0298
Echinococcus multilocularis	General substrate transporter	0.006	0.0081	0.0081
Echinococcus multilocularis	GPCR, family 2	0.005	0.0066	0.0066
Toxoplasma gondii	hypothetical protein	0.1092	0.1706	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0035	0.2013
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0014	0.0745
Echinococcus multilocularis	cysteine protease	0.0031	0.0035	0.0035
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0024	0.0025	0.0025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0035	0.2013
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Schistosoma mansoni	hypothetical protein	0.0198	0.0298	0.0298
Brugia malayi	AMP-binding enzyme family protein	0.0055	0.0073	0.0073
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.1092	0.1706	0.1706
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0198	0.0298	0.0298
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0198	0.0298	0.0298
Schistosoma mansoni	eyes absent homolog	0.0068	0.0093	0.0093
Echinococcus granulosus	sex peptide receptor	0.0198	0.0298	0.0298
Schistosoma mansoni	hypothetical protein	0.005	0.0066	0.0066
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0039	0.0048	0.0047
Onchocerca volvulus		0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0132	0.0131
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0198	0.0298	0.0298
Schistosoma mansoni	kinase	0.0058	0.0078	0.0078
Brugia malayi	AMP-binding enzyme family protein	0.0016	0.0012	0.0012
Schistosoma mansoni	cercarial elastase (S01 family)	0.0024	0.0025	0.0025
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0198	0.0298	0.0298
Brugia malayi	hypothetical protein	0.0198	0.0298	0.0298
Entamoeba histolytica	hypothetical protein	0.0055	0.0074	0.4004
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0056	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0014	0.0701
Echinococcus multilocularis	fmrfamide receptor	0.0198	0.0298	0.0298
Brugia malayi	Latrophilin receptor protein 2	0.005	0.0066	0.0066
Echinococcus multilocularis	sodium and chloride dependent glycine	0.1153	0.1801	0.1801
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Onchocerca volvulus		0.0024	0.0025	0.0024
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0166	1
Brugia malayi	Major Facilitator Superfamily protein	0.001	0.0002	0.0002
Brugia malayi	putative neuropeptide receptor NPR1	0.0198	0.0298	0.0298
Echinococcus multilocularis	sex peptide receptor	0.0198	0.0298	0.0298
Echinococcus granulosus	rhodopsin orphan GPCR	0.0198	0.0298	0.0298
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0198	0.0298	0.0298
Echinococcus granulosus	orexin receptor type 2	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0016	0.0012	0.0062
Schistosoma mansoni	hypothetical protein	0.0034	0.0041	0.0041
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0198	0.0298	0.0298
Onchocerca volvulus		0.001	0.0002	0.0002
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Brugia malayi	serine/threonine-protein kinase plk-2	0.0114	0.0166	0.0166
Echinococcus granulosus	neuropeptide receptor	0.0198	0.0298	0.0298
Echinococcus multilocularis	cpg binding protein	0.0026	0.0028	0.0028
Schistosoma mansoni	biogenic amine receptor	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0051	0.0051
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0016	0.0012	0.1387
Schistosoma mansoni	sugar transporter	0.001	0.0002	0.0002
Brugia malayi	Dopamine receptor	0.0198	0.0298	0.0298
Schistosoma mansoni	cathepsin F (C01 family)	0.0031	0.0035	0.0035
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0114	0.0166	0.0166
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.007	0.0097	0.0097
Trypanosoma cruzi	hexose transporter, putative	0.0022	0.0021	0.1178
Onchocerca volvulus		0.1092	0.1706	0.1706
Echinococcus granulosus	rhodopsin orphan GPCR	0.0198	0.0298	0.0298
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0166	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0198	0.0298	0.0298
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.0035	0.2051
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Brugia malayi	hypothetical protein	0.0198	0.0298	0.0298
Echinococcus granulosus	7TM GPCR rhodopsin	0.0198	0.0298	0.0298
Echinococcus granulosus	neuropeptide Y receptor	0.0198	0.0298	0.0298
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0198	0.0298	0.0298
Trypanosoma brucei	glucose transporter 2A	0.0022	0.0021	0.1136
Echinococcus multilocularis	neuropeptides capa receptor	0.0198	0.0298	0.0298
Echinococcus granulosus	Mastin	0.0024	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.0002
Brugia malayi	hypothetical protein	0.0068	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.1153	0.1801	0.1801
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0198	0.0298	0.0298
Echinococcus granulosus	GPCR family 2	0.005	0.0066	0.0066
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0016	0.0012	0.1387
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.1092	0.1706	0.1706
Echinococcus granulosus	cathepsin L	0.0017	0.0014	0.0014
Echinococcus granulosus	Sugar transporter ERD6 protein	0.001	0.0002	0.0002
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.001	0.0002	0.5
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0114	0.0166	0.0166
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0025	0.3168
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0031	0.0035	0.0035
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0039	0.0048	0.0047
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0035	0.2013
Giardia lamblia	Kinase, PLK	0.0114	0.0166	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0198	0.0298	0.0298
Trypanosoma cruzi	cysteine proteinase, putative	0.0017	0.0014	0.0745
Brugia malayi	G protein-coupled receptor	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.0002
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0198	0.0298	0.0298
Loa Loa (eye worm)	solute carrier family 6 member 4	0.6363	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0035	0.2013
Onchocerca volvulus		0.0198	0.0298	0.0298
Schistosoma mansoni	glucose transport protein	0.007	0.0097	0.0097
Schistosoma mansoni	cercarial elastase (S01 family)	0.0024	0.0025	0.0025
Echinococcus granulosus	muscleblind protein	0.015	0.0223	0.0223
Plasmodium vivax	vivapain-1	0.0017	0.0014	0.0072
Onchocerca volvulus		0.0024	0.0025	0.0024
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0009	0.0001	0.0001
Echinococcus multilocularis	somatostatin receptor	0.0198	0.0298	0.0298
Loa Loa (eye worm)	fibroinase	0.0031	0.0035	0.0035
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0039	0.0048	0.0048
Echinococcus multilocularis	serotonin receptor	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.1092	0.1706	0.1706
Onchocerca volvulus		0.001	0.0002	0.0002
Echinococcus multilocularis	g protein coupled receptor	0.0198	0.0298	0.0298
Echinococcus granulosus	Protein patched homolog 1	0.0036	0.0043	0.0043
Schistosoma mansoni	glucose transporter	0.001	0.0002	0.0002
Loa Loa (eye worm)	oxidoreductase	0.0016	0.0012	0.0012
Echinococcus multilocularis	sodium and chloride dependent glycine	0.1153	0.1801	0.1801
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0031	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0116	0.0116
Schistosoma mansoni	transcription factor LCR-F1	0.0055	0.0074	0.0074
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0021	0.0021	0.1161
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0014	0.0111
Schistosoma mansoni	myosin xvIII	0.0198	0.0298	0.0298
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0198	0.0298	0.0298
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0198	0.0298	0.0298
Brugia malayi	hypothetical protein	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.015	0.0223	0.0223
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0047	0.006	0.0341
Echinococcus granulosus	transmembrane protease serine 3	0.0024	0.0025	0.0025
Echinococcus granulosus	somatostatin receptor	0.0198	0.0298	0.0298
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0035	0.0035
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.1092	0.1706	0.1706
Schistosoma mansoni	cpg binding protein	0.0026	0.0028	0.0028
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Onchocerca volvulus		0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0035	0.2013
Echinococcus granulosus	expressed conserved protein	0.0078	0.011	0.011
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0198	0.0298	0.0298
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0039	0.0048	0.642
Schistosoma mansoni	cercarial elastase (S01 family)	0.0024	0.0025	0.0025
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.001	0.0002	0.0002
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.1092	0.1706	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0019	0.0016	0.0082
Loa Loa (eye worm)	hypothetical protein	0.1092	0.1706	0.1706
Onchocerca volvulus		0.001	0.0002	0.0002
Leishmania major	cathepsin L-like protease	0.0031	0.0035	0.2013
Brugia malayi	hypothetical protein	0.0198	0.0298	0.0298
Brugia malayi	cathepsin F-like cysteine proteinase	0.0009	0.0001	0.0001
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0016	0.0012	0.0641
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0039	0.0048	0.0048
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0016	0.0012	0.1387
Echinococcus multilocularis	orexin receptor type 2	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.001	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Plasmodium vivax	hexose transporter	0.007	0.0097	0.0559
Onchocerca volvulus		0.0082	0.0116	0.0116
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0025	0.0026	0.0025
Schistosoma mansoni	hypothetical protein	0.0198	0.0298	0.0298
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0198	0.0298	0.0298
Leishmania major	cysteine peptidase A (CPA)	0.0031	0.0035	0.2013
Loa Loa (eye worm)	G-protein coupled receptor	0.0198	0.0298	0.0298
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0035	0.0035
Entamoeba histolytica	hypothetical protein	0.0055	0.0074	0.4004
Onchocerca volvulus	Putative transporter	0.001	0.0002	0.0002
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0016	0.0012	0.0641
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0198	0.0298	0.0298
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0198	0.0298	0.0298
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0092	0.0132	0.0132
Echinococcus multilocularis	neuropeptide Y receptor	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.1092	0.1706	0.1706
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.001	0.0002	0.0002
Toxoplasma gondii	facilitative glucose transporter GT1	0.007	0.0097	0.0555
Brugia malayi	Melatonin receptor type 1A	0.0198	0.0298	0.0298
Loa Loa (eye worm)	sugar transporter	0.001	0.0002	0.0002
Echinococcus multilocularis	expressed conserved protein	0.0078	0.011	0.011
Onchocerca volvulus		0.0198	0.0298	0.0298
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.1092	0.1706	0.1706
Echinococcus granulosus	neuropeptide receptor	0.0198	0.0298	0.0298
Plasmodium vivax	vivapain-3	0.0017	0.0014	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0093	0.0093
Echinococcus multilocularis	sterol regulatory element binding protein	0.0036	0.0043	0.0043
Echinococcus multilocularis	g protein coupled receptor	0.0198	0.0298	0.0298
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0039	0.0048	0.0048
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0198	0.0298	0.0298
Trypanosoma cruzi	cysteine proteinase, putative	0.0017	0.0014	0.0745
Mycobacterium ulcerans	acyl-CoA synthetase	0.0016	0.0012	0.1387
Schistosoma mansoni	adenoreceptor	0.0198	0.0298	0.0298
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.007	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0025	0.0024
Brugia malayi	RE15519p	0.0198	0.0298	0.0298
Onchocerca volvulus		0.0198	0.0298	0.0298
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0016	0.0012	0.0596
Onchocerca volvulus		0.0055	0.0073	0.0073
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.1092	0.1706	0.1706
Mycobacterium ulcerans	acyl-CoA synthetase	0.0016	0.0012	0.1387
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.1092	0.1706	0.1706
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0198	0.0298	0.0298
Schistosoma mansoni	hypothetical protein	0.0055	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0025	0.0024
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0198	0.0298	0.0298
Brugia malayi	MH2 domain containing protein	0.012	0.0176	0.0176
Echinococcus granulosus	cpg binding protein	0.0026	0.0028	0.0028
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0166	1
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.0076	0.4474
Schistosoma mansoni	biogenic amine receptor	0.0198	0.0298	0.0298
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0012	0.0012
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.1153	0.1801	0.1801
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0022	0.0021	0.1136
Echinococcus granulosus	tm gpcr rhodopsin	0.0198	0.0298	0.0298
Brugia malayi	CXXC zinc finger family protein	0.0025	0.0026	0.0025
Schistosoma mansoni	amine GPCR	0.0198	0.0298	0.0298
Brugia malayi	hypothetical protein	0.0198	0.0298	0.0298
Onchocerca volvulus		0.0198	0.0298	0.0298
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0198	0.0298	0.0298
Schistosoma mansoni	cpg binding protein	0.0025	0.0026	0.0026
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.1092	0.1706	1
Echinococcus granulosus	solute carrier family 22	0.001	0.0002	0.0002
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0166	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0039	0.0048	0.642
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0055	0.0074	0.0074
Echinococcus multilocularis	G protein coupled receptor 139	0.0198	0.0298	0.0298
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0198	0.0298	0.0298
Trypanosoma cruzi	PAB1-binding protein , putative	0.0019	0.0016	0.0892
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0035	0.2013
Trypanosoma brucei	glucose transporter 1E	0.0022	0.0021	0.1136
Echinococcus multilocularis	dro:myosuppressin receptor	0.0198	0.0298	0.0298
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0021	0.1136
Echinococcus granulosus	General substrate transporter	0.006	0.0081	0.0081
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0055	0.0073	1
Onchocerca volvulus		0.0031	0.0035	0.0035
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0198	0.0298	0.0298
Echinococcus granulosus	cathepsin l1	0.0021	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.6363	1	1
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0024	0.0025	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0035	0.2013
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0055	0.0073	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.1153	0.1801	0.1801
Entamoeba histolytica	cysteine proteinase 2	0.0017	0.0014	0.0111
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.007	0.0097	0.0097
Brugia malayi	Major Facilitator Superfamily protein	0.001	0.0002	0.0002
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0016	0.0012	0.1387
Onchocerca volvulus		0.0016	0.0012	0.0012
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0035	0.2013
Echinococcus granulosus	7tm_1 domain containing protein	0.0198	0.0298	0.0298
Brugia malayi	G protein-coupled receptor F59B2.13	0.0198	0.0298	0.0298
Echinococcus granulosus	dro:myosuppressin receptor	0.0198	0.0298	0.0298
Onchocerca volvulus		0.0031	0.0035	0.0035
Treponema pallidum	sodium- and chloride- dependent transporter	0.6363	1	0.5
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0022	0.0021	0.1136
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0198	0.0298	0.0298
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0039	0.0048	0.642
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0039	0.0048	0.0048
Toxoplasma gondii	hypothetical protein	0.1092	0.1706	1
Brugia malayi	hypothetical protein	0.0019	0.0016	0.0016
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0022	0.0021	0.1136
Trichomonas vaginalis	antibiotic synthetase, putative	0.0016	0.0012	0.0596
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0035	0.2013
Echinococcus multilocularis	solute carrier family 22	0.001	0.0002	0.0002
Loa Loa (eye worm)	G-protein coupled receptor	0.0198	0.0298	0.0298
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0034	0.004	0.2303
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0035	0.0035
Schistosoma mansoni	hypothetical protein	0.007	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.1092	0.1706	0.1706
Echinococcus granulosus	rhodopsin orphan GPCR	0.0198	0.0298	0.0298
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0035	0.2013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0021	0.1118
Onchocerca volvulus		0.0024	0.0025	0.0024
Loa Loa (eye worm)	major facilitator superfamily transporter	0.001	0.0002	0.0002
Onchocerca volvulus		0.0021	0.0021	0.002
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0031	0.0035	0.0194
Echinococcus granulosus	solute carrier family 22	0.001	0.0002	0.0002
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.0166	1
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0035	0.1506
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0031	0.0035	0.0035
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.1092	0.1706	0.1706
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0024	0.0025	0.0025
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0198	0.0298	0.0298
Echinococcus granulosus	cathepsin L cysteine protease	0.0017	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0025	0.0024
Brugia malayi	Dopamine receptor protein 1	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0198	0.0298	0.0298
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0017	0.0014	0.0068
Plasmodium falciparum	ataxin-2 like protein, putative	0.0019	0.0016	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.005	0.0066	0.0066
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0082	0.0116	0.0116
Onchocerca volvulus		0.0024	0.0025	0.0024
Schistosoma mansoni	cpg binding protein	0.0026	0.0028	0.0028
Onchocerca volvulus	Cathepsin F homolog	0.0031	0.0035	0.0035
Trypanosoma cruzi	cruzipain precursor, putative	0.0031	0.0035	0.2051
Echinococcus granulosus	neuropeptides capa receptor	0.0198	0.0298	0.0298
Schistosoma mansoni	cathepsin F (C01 family)	0.0021	0.0021	0.0021
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0198	0.0298	0.0298
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.0166	1
Brugia malayi	hypothetical protein	0.0024	0.0025	0.0024
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0198	0.0298	0.0298
Trichomonas vaginalis	antibiotic synthetase, putative	0.0016	0.0012	0.0596
Mycobacterium ulcerans	acyl-CoA synthetase	0.0016	0.0012	0.1387
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0035	0.2013
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0035	0.2013
Brugia malayi	cathepsin L-like precursor	0.0021	0.0021	0.002
Brugia malayi	hypothetical protein	0.001	0.0002	0.0002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0198	0.0298	0.0298
Echinococcus multilocularis	synaptic vesicle 2 protein	0.001	0.0002	0.0002
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0035	0.2013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0035	0.2013
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0014	0.0009	0.089
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0198	0.0298	0.0298
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0017	0.0014	0.0701
Onchocerca volvulus		0.001	0.0002	0.0002
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0021	0.0021	0.002
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0035	0.0035
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.1092	0.1706	0.1706
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0035	0.2013
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0016	0.0012	0.0012
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.1153	0.1801	0.1801
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0035	0.2013
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0035	0.1506
Echinococcus granulosus	tm gpcr rhodopsin	0.0198	0.0298	0.0298
Loa Loa (eye worm)	latrophilin receptor protein 2	0.005	0.0066	0.0066
Brugia malayi	larval opioid receptor	0.0198	0.0298	0.0298
Plasmodium falciparum	ataxin-2 like protein, putative	0.0019	0.0016	0.0082
Entamoeba histolytica	cysteine proteinase, putative	0.0021	0.0021	0.0555
Brugia malayi	AKH receptor	0.0198	0.0298	0.0298
Trypanosoma cruzi	hexose transporter, putative	0.001	0.0002	0.0048
Schistosoma mansoni	neuropeptide receptor	0.0198	0.0298	0.0298
Onchocerca volvulus		0.1092	0.1706	0.1706
Onchocerca volvulus		0.0198	0.0298	0.0298
Echinococcus granulosus	G protein coupled receptor 139	0.0198	0.0298	0.0298
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0016	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0198	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.1153	0.1801	0.1801
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0035	0.0035
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0041	0.0051	0.6918
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0051	0.0051
Schistosoma mansoni	hypothetical protein	0.0024	0.0025	0.0025
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.1092	0.1706	0.1706
Onchocerca volvulus		0.0198	0.0298	0.0298
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0017	0.0014	0.0745
Plasmodium falciparum	hexose transporter	0.007	0.0097	0.0555
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0198	0.0298	0.0298
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0035	0.2013
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0198	0.0298	0.0298
Schistosoma mansoni	biogenic amine receptor	0.0198	0.0298	0.0298
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0016	0.0012	0.1387
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0198	0.0298	0.0298
Onchocerca volvulus		0.0041	0.0052	0.0052
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0012	0.1387
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0016	0.0012	0.0641
Echinococcus multilocularis	muscleblind protein	0.015	0.0223	0.0223
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0016	0.0012	0.0012
Schistosoma mansoni	cercarial elastase (S01 family)	0.0024	0.0025	0.0025
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0016	0.0012	0.0641
Onchocerca volvulus		0.0198	0.0298	0.0298
Loa Loa (eye worm)	ctsf protein	0.0031	0.0035	0.0035
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0014	0.0111
Brugia malayi	G-protein coupled receptor	0.0198	0.0298	0.0298
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0035	0.2013
Onchocerca volvulus		0.001	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0012	0.0012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0035	0.2013
Onchocerca volvulus		0.0198	0.0298	0.0298
Brugia malayi	sulfakinin receptor protein	0.0198	0.0298	0.0298
Echinococcus granulosus	solute carrier family 22	0.001	0.0002	0.0002
Brugia malayi	AMP-binding enzyme family protein	0.0055	0.0073	0.0073
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0016	0.0012	0.1387
Onchocerca volvulus		0.001	0.0002	0.0002
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0017	0.0014	0.0701
Toxoplasma gondii	cathepsin B	0.0034	0.004	0.0222
Echinococcus granulosus	synaptic vesicle 2 protein	0.001	0.0002	0.0002

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	26.6795 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2145333

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1699287