Detailed information for compound 1710466

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 660.824 | Formula: C39H40N4O4S
  • H donors: 2 H acceptors: 4 LogP: 6.42 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@@H](N1C[C@H](C)[C@@H](CN(Cc2ccc(cc2)c2ccccc2)C)Oc2c(C1=O)cccc2NC(=O)c1ccc(cc1)c1nccs1)C
  • InChi: 1S/C39H40N4O4S/c1-26-22-43(27(2)25-44)39(46)33-10-7-11-34(41-37(45)31-16-18-32(19-17-31)38-40-20-21-48-38)36(33)47-35(26)24-42(3)23-28-12-14-30(15-13-28)29-8-5-4-6-9-29/h4-21,26-27,35,44H,22-25H2,1-3H3,(H,41,45)/t26-,27-,35+/m0/s1
  • InChiKey: WNMJLARWBKXIKH-PDTNBVABSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ImpB/MucB/SamB family protein 0.0179 0.1675 0.4457
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.17 0.17
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0059 0.0483 0.09
Brugia malayi phosphofructokinase 0.0239 0.2272 0.6046
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.17 0.17
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0046 0.0046
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0037 0.0263 0.07
Loa Loa (eye worm) hypothetical protein 0.0054 0.0428 0.114
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0123 0.0207
Echinococcus multilocularis GPCR, family 2 0.0018 0.0066 0.0154
Echinococcus multilocularis dnaJ subfamily B 0.0441 0.4286 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0065 0.0534 0.1396
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0043 0.0317 0.0581
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0239 0.2272 0.2272
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0012 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0303 0.0806
Entamoeba histolytica phosphofructokinase, putative 0.0239 0.2272 0.6046
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0069 0.0579 0.1539
Entamoeba histolytica hypothetical protein 0.0042 0.0306 0.0814
Schistosoma mansoni DNA helicase recq5 0.0043 0.0315 0.0736
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0303 0.0806
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0065 0.0534 0.1396
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0303 0.0303
Brugia malayi exodeoxyribonuclease III family protein 0.0043 0.0317 0.0845
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0031 0.0195 0.0195
Trichomonas vaginalis phosphofructokinase, putative 0.0239 0.2272 0.6035
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0303 0.0806
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0684 0.1286
Mycobacterium tuberculosis Conserved hypothetical protein 0.0534 0.5215 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0213
Mycobacterium ulcerans DNA polymerase IV 0.0182 0.17 0.3241
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0684 0.1286
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.016 0.1484 0.2825
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0037 0.0254 0.0676
Treponema pallidum exodeoxyribonuclease (exoA) 0.0043 0.0317 0.0577
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0174 0.1623 0.1623
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.0123 0.0327
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.007 0.0587 0.1538
Brugia malayi Phosphoglycerate kinase 0.0142 0.131 0.3486
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.048 0.4675 0.4675
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0308 0.0718
Brugia malayi hypothetical protein 0.0018 0.007 0.0186
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0046 0.0121
Loa Loa (eye worm) hypothetical protein 0.0038 0.0271 0.072
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0107 0.0107
Toxoplasma gondii propionate-CoA ligase 0.0023 0.0123 0.0327
Trypanosoma brucei DNA polymerase IV, putative 0.0182 0.17 0.17
Trypanosoma brucei unspecified product 0.0083 0.0722 0.0722
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0104 0.0923 0.2153
Trypanosoma cruzi ubiquitin-activating enzyme-like protein 0.0017 0.0058 0.0058
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0046 0.0094
Leishmania major phosphoglycerate kinase C, glycosomal 0.0388 0.3758 0.3758
Loa Loa (eye worm) RecQ helicase 0.0103 0.0921 0.2449
Loa Loa (eye worm) hypothetical protein 0.0043 0.0315 0.0839
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0015 0.0013
Schistosoma mansoni 6-phosphofructokinase 0.0239 0.2272 0.5301
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0043 0.0315 0.0736
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0065 0.0534 0.1169
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.3154 0.8387
Toxoplasma gondii hypothetical protein 0.0019 0.008 0.0213
Loa Loa (eye worm) calcium channel 0.0104 0.0923 0.2456
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0451 0.0837
Toxoplasma gondii hypothetical protein 0.0054 0.0428 0.114
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0306 0.0714
Entamoeba histolytica exonuclease, putative 0.0012 0.001 0.0027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0043 0.0317 0.0317
Trypanosoma brucei phosphoglycerate kinase 0.0142 0.131 0.131
Trypanosoma cruzi DNA polymerase kappa, putative 0.0182 0.17 0.17
Entamoeba histolytica hypothetical protein 0.0042 0.0306 0.0814
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.093 0.2169
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.17 0.17
Leishmania major exosome subunit rrp6p homologue, putative 0.0013 0.0021 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.3154 0.8387
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0213
Trypanosoma cruzi DNA damage repair protein, putative 0.0038 0.0264 0.0264
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0303 0.0707
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0066 0.0176
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.093 0.2169
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.048 0.4675 0.4675
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0308 0.0794
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0121 0.1096 0.2557
Onchocerca volvulus 0.0031 0.0199 0.2029
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0015 0.0013
Echinococcus multilocularis bloom syndrome protein 0.0103 0.0921 0.2148
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0872 0.0872
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0451 0.0837
Echinococcus multilocularis flap endonuclease 1 0.0059 0.0482 0.1124
Entamoeba histolytica Flap nuclease, putative 0.0059 0.0482 0.1282
Loa Loa (eye worm) hypothetical protein 0.008 0.0684 0.1819
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0043 0.0315 0.0736
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0091 0.0795 0.2095
Trypanosoma brucei DNA damage repair protein, putative 0.0038 0.0264 0.0264
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0123 0.0123
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0315 0.0839
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.3154 0.8387
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.008 0.0684 0.1286
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.0123 0.0207
Loa Loa (eye worm) hypothetical protein 0.0059 0.0483 0.1285
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0303 0.0781
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0066 0.055 0.1464
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0303 0.0781
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0123 0.0123
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0012 0.001 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0264 0.0264
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0123 0.0207
Leishmania major pantothenate kinase subunit, putative 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0059 0.0483 0.1285
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0308 0.0794
Schistosoma mansoni hypothetical protein 0.0018 0.0066 0.0154
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0123 0.0287
Mycobacterium tuberculosis Conserved hypothetical alanine rich protein 0.0013 0.0021 0.0011
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0043 0.0317 0.0317
Entamoeba histolytica recQ family helicase, putative 0.0055 0.0441 0.1172
Toxoplasma gondii ThiF family protein 0.0036 0.0244 0.065
Schistosoma mansoni terminal deoxycytidyl transferase 0.0121 0.1096 0.2557
Trypanosoma brucei phosphoglycerate kinase, putative 0.0142 0.131 0.131
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0046 0.0046
Echinococcus multilocularis amyloid beta A4 protein 0.0074 0.0628 0.1466
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0066 0.0176
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0023 0.0123 0.0274
Schistosoma mansoni glutaminase 0.0306 0.2942 0.6865
Trypanosoma cruzi DNA polymerase eta, putative 0.0179 0.1675 0.1675
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0099 0.0262
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0123 0.0327
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0254 0.0254
Toxoplasma gondii hypothetical protein 0.0163 0.1521 0.4046
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0046 0.0094
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0027
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0142 0.131 0.131
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0003 0.0003
Onchocerca volvulus 0.0023 0.0123 0.1256
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0152
Giardia lamblia Flap structure-specific endonuclease 0.0059 0.0482 0.1258
Leishmania major ubiquitin-activating enzyme-like protein 0.0036 0.0244 0.0244
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.1773 0.4137
Trypanosoma cruzi DNA damage repair protein, putative 0.0038 0.0264 0.0264
Schistosoma mansoni exonuclease 0.0012 0.001 0.0024
Trichomonas vaginalis DNA polymerase eta, putative 0.0182 0.17 0.451
Plasmodium falciparum phosphoglycerate kinase 0.0388 0.3758 1
Schistosoma mansoni cpg binding protein 0.0031 0.0199 0.0463
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.016 0.1484 0.3916
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0104 0.0923 0.2153
Plasmodium vivax phosphoglycerate kinase, putative 0.0388 0.3758 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0065 0.0534 0.1396
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0104 0.0923 0.2153
Schistosoma mansoni voltage-gated cation channel 0.0104 0.0923 0.2153
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0054 0.0428 0.0999
Schistosoma mansoni blooms syndrome DNA helicase 0.0082 0.0704 0.1642
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0043 0.0315 0.0839
Echinococcus granulosus 6 phosphofructokinase 0.0239 0.2272 0.5301
Loa Loa (eye worm) hypothetical protein 0.0151 0.1395 0.3713
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0021 0.0099 0.0236
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0189 0.1773 0.4719
Trypanosoma brucei exonuclease, putative 0.0012 0.001 0.001
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0037 0.0263 0.07
Loa Loa (eye worm) hypothetical protein 0.0022 0.0106 0.0283
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0043 0.0315 0.0814
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0063 0.0518 0.0518
Loa Loa (eye worm) XPG I-region family protein 0.0012 0.001 0.0027
Loa Loa (eye worm) TK/ALK protein kinase 0.0018 0.007 0.0186
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0043 0.0317 0.0845
Schistosoma mansoni hypothetical protein 0.0018 0.0066 0.0154
Trichomonas vaginalis glutaminase, putative 0.0306 0.2942 0.7824
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0046 0.0094
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0143 0.1312 0.1312
Echinococcus multilocularis cpg binding protein 0.0033 0.0216 0.0505
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0303 0.0707
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0036 0.0244 0.0244
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0142 0.131 0.131
Echinococcus multilocularis dna polymerase eta 0.0179 0.1675 0.3908
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0055 0.0441 0.0441
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0327 0.3154 0.8392
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0123 0.0207
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0447 0.1189
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0043 0.0317 0.074
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0303 0.0303
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0046 0.0046
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0123 0.0301
Trichomonas vaginalis DNA helicase recq, putative 0.0103 0.0921 0.2429
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0303 0.0707
Mycobacterium tuberculosis Conserved hypothetical protein 0.0121 0.1096 0.2079
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0107 0.0284
Schistosoma mansoni 6-phosphofructokinase 0.0239 0.2272 0.5301
Brugia malayi ImpB/MucB/SamB family protein 0.0121 0.1096 0.2917
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0123 0.0327
Loa Loa (eye worm) hypothetical protein 0.0018 0.007 0.0186
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0143 0.1312 0.1312
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0151 0.1395 0.3255
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0487 0.1297
Giardia lamblia Ubiquitin-activating enzyme E1 1 0.0017 0.0058 0.0127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.093 0.2169
Echinococcus granulosus dnaJ subfamily B 0.0441 0.4286 1
Schistosoma mansoni phosphoglycerate kinase 0.0388 0.3758 0.8767
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.093 0.2169
Brugia malayi 3'-5' exonuclease family protein 0.0013 0.0021 0.0055
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.0123 0.0207
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0046 0.0094
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.0123 0.0207
Trypanosoma brucei ribosomal RNA processing protein 6 0.0013 0.0021 0.0021
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.0017 0.0058 0.0127
Echinococcus granulosus Eukaryotic translation initiation factor 4H 0.0151 0.1395 0.3255
Plasmodium falciparum DNA repair protein REV1, putative 0.0038 0.0264 0.0678
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.008 0.0684 0.1286
Loa Loa (eye worm) hypothetical protein 0.0056 0.0447 0.1189
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0036 0.0244 0.0624
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.093 0.2169
Echinococcus granulosus amyloid beta A4 protein 0.0074 0.0628 0.1466
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0447 0.1189
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0043 0.0315 0.0736
Trypanosoma brucei DNA repair protein RAD2, putative 0.0012 0.001 0.001
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0011 0.0003 0.0003
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.0123 0.0207
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0306 0.0714
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0.0091 0.0145
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0123 0.0123
Trypanosoma cruzi ribosomal RNA processing protein 6, putative 0.0013 0.0021 0.0021
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0123 0.0207
Schistosoma mansoni phosphoglycerate kinase 0.0388 0.3758 0.8767
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0044 0.0328 0.0766
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0447 0.1189
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0123 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0872 0.0872
Brugia malayi Flap endonuclease-1 0.0059 0.0482 0.1282
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.0123 0.0207
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0012 0.001 0.0027
Brugia malayi polk-prov protein 0.0098 0.0869 0.2312
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0869 0.0869
Entamoeba histolytica hypothetical protein 0.0042 0.0306 0.0814
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.0123 0.0207
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0104 0.0923 0.2153
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0036 0.0244 0.0244
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0104 0.0923 0.2153
Echinococcus granulosus exonuclease 1 0.0012 0.001 0.0024
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0684 0.0684
Schistosoma mansoni ap endonuclease 0.0043 0.0317 0.074
Trichomonas vaginalis phosphofructokinase, putative 0.0239 0.2272 0.6035
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0142 0.131 0.131
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0303 0.0781
Entamoeba histolytica phosphofructokinase, putative 0.0239 0.2272 0.6046
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1312 0.1312
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0308 0.0794
Plasmodium vivax ubiquitin activating enzyme, putative 0.0054 0.0428 0.1115
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0065 0.0534 0.1396
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.17 0.17
Entamoeba histolytica acyl-CoA synthetase, putative 0.008 0.0684 0.1819
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0239 0.2272 0.434
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0451 0.0837
Schistosoma mansoni polymyositis/scleroderma autoantigen-related 0.0013 0.0021 0.0048
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0123 0.0327
Leishmania major ATP-dependent phosphofructokinase 0.0239 0.2272 0.2272
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0388 0.3758 0.7198
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0264 0.0264
Trichomonas vaginalis phosphofructokinase, putative 0.0239 0.2272 0.6035
Brugia malayi Bloom's syndrome protein homolog 0.0103 0.0921 0.2449
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.17 0.17
Echinococcus multilocularis Eukaryotic translation initiation factor 4H 0.0151 0.1395 0.3255
Mycobacterium ulcerans phosphoglycerate kinase 0.0388 0.3758 0.7198
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0388 0.3758 0.3758
Onchocerca volvulus 0.0017 0.0057 0.0583
Onchocerca volvulus 0.0017 0.0057 0.0583
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0308 0.0794
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0065 0.0534 0.0154
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0066 0.0154
Entamoeba histolytica hypothetical protein 0.0042 0.0306 0.0814
Onchocerca volvulus 0.0023 0.0123 0.1256
Trypanosoma brucei DNA polymerase IV, putative 0.0182 0.17 0.17
Chlamydia trachomatis phosphoglycerate kinase 0.0388 0.3758 1
Schistosoma mansoni cpg binding protein 0.0033 0.0216 0.0505
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.001 0.001
Brugia malayi ThiF family protein 0.0054 0.0428 0.114
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0012 0.001 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.008 0.0684 0.1286
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0315 0.0839
Mycobacterium ulcerans fatty-acid-CoA ligase 0.008 0.0684 0.1286
Echinococcus granulosus expressed protein 0.0037 0.0263 0.0613
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0317 0.082
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0012 0.001 0.0027
Leishmania major DNA polymerase eta, putative 0.0179 0.1675 0.1675
Loa Loa (eye worm) hypothetical protein 0.0179 0.1675 0.4457
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.001 0.001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0327 0.3154 0.8392
Loa Loa (eye worm) hypothetical protein 0.0018 0.007 0.0186
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0123 0.0207
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0121 0.1096 0.2557
Trypanosoma brucei DNA polymerase IV, putative 0.0166 0.1551 0.1551
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0308 0.0819
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0308 0.0308
Trichomonas vaginalis phosphofructokinase, putative 0.0065 0.0534 0.1396
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0136 0.1246 0.1246
Entamoeba histolytica phosphoglycerate kinase, putative 0.0388 0.3758 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0239 0.2272 0.6046
Trichomonas vaginalis rotamase, putative 0.0037 0.0254 0.0651
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0043 0.0317 0.0836
Echinococcus granulosus GPCR family 2 0.0018 0.0066 0.0154
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0043 0.0317 0.0581
Schistosoma mansoni blooms syndrome DNA helicase 0.0022 0.0107 0.0249
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0123 0.0123
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.0123 0.0207
Echinococcus multilocularis dna polymerase kappa 0.0182 0.17 0.3967
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0143 0.1312 0.1312
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0012 0.001 0.0024
Schistosoma mansoni SET domain protein 0.0015 0.0037 0.0086
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0013 0.0019 0.0045
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0015 0.0013
Leishmania major DNA polymerase kappa, putative 0.0136 0.1246 0.1246
Trichomonas vaginalis phosphofructokinase, putative 0.0239 0.2272 0.6035
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0317 0.082
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0872 0.0872
Trypanosoma brucei glucosidase, putative 0.0042 0.0308 0.0308
Onchocerca volvulus 0.008 0.0684 0.6981
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0264 0.0264
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0065 0.0534 0.1396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.3154 0.8387
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0239 0.2272 0.2272
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.17 0.17
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0107 0.0107
Entamoeba histolytica recQ family DNA helicase 0.0022 0.0107 0.0284
Echinococcus multilocularis geminin 0.019 0.1782 0.4158
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.17 0.17
Loa Loa (eye worm) hypothetical protein 0.0071 0.0599 0.1595
Echinococcus multilocularis voltage dependent calcium channel 0.0104 0.0923 0.2153
Entamoeba histolytica exosome component 10, putative 0.0013 0.0021 0.0055
Echinococcus granulosus lysosomal alpha glucosidase 0.0189 0.1773 0.4137
Trichomonas vaginalis rotamase, putative 0.0037 0.0263 0.0674
Trichomonas vaginalis DNA helicase recq, putative 0.0055 0.0441 0.1148
Mycobacterium ulcerans glutaminase 0.0306 0.2942 0.5629
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0003 0.0003
Echinococcus multilocularis sodium channel protein 0.0044 0.0328 0.0766
Schistosoma mansoni DNA polymerase eta 0.0179 0.1675 0.3908
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.0123 0.0123
Entamoeba histolytica deoxycytidyl transferase, putative 0.0121 0.1096 0.2917
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0308 0.0819
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.008 0.0684 0.1774
Schistosoma mansoni hypothetical protein 0.0042 0.0306 0.0714
Brugia malayi 6-phosphofructokinase 0.0239 0.2272 0.6046
Schistosoma mansoni ap endonuclease 0.0043 0.0317 0.074
Onchocerca volvulus 0.0023 0.0123 0.1256
Echinococcus granulosus phosphoglycerate kinase 1 0.0388 0.3758 0.8767
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0303 0.0707
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0123 0.0207
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0054 0.0428 0.0999
Toxoplasma gondii phosphofructokinase PFKII 0.0065 0.0534 0.142
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0123 0.0327
Mycobacterium ulcerans hypothetical protein 0.0038 0.0264 0.0479
Trichomonas vaginalis phosphofructokinase, putative 0.0065 0.0534 0.1396
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0049 0.0379 0.0884
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0388 0.3758 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0059 0.0483 0.1261
Schistosoma mansoni flap endonuclease-1 0.0054 0.0425 0.0991
Brugia malayi 6-phosphofructokinase 0.0239 0.2272 0.6046
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0043 0.0317 0.0317
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0264 0.0264
Brugia malayi Muscle positioning protein 4 0.0017 0.0057 0.0152
Trichomonas vaginalis DNA helicase recq1, putative 0.0103 0.0921 0.2429
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0317 0.082
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0121 0.1096 0.2557
Loa Loa (eye worm) glutaminase 0.0306 0.2942 0.783
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.17 0.17
Trypanosoma cruzi DNA polymerase kappa, putative 0.0182 0.17 0.17
Echinococcus granulosus cpg binding protein 0.0033 0.0216 0.0505
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0451 0.0837
Trypanosoma brucei phosphoglycerate kinase 0.0388 0.3758 0.3758
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.3154 0.8387
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.008 0.0684 0.1286
Schistosoma mansoni amyloid beta A4 protein related 0.0074 0.0628 0.1466
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0271 0.072
Trypanosoma brucei phosphoglycerate kinase 0.0388 0.3758 0.3758
Trypanosoma cruzi DNA polymerase kappa, putative 0.0182 0.17 0.17
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0021 0.0028
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0065 0.0534 0.142
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0059 0.0482 0.0482
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.1773 0.4137
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0308 0.0794
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0684 0.0684
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.093 0.2169
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0065 0.0534 0.142
Echinococcus multilocularis 6 phosphofructokinase 0.0239 0.2272 0.5301
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0066 0.0176
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0039 0.0276 0.0643
Mycobacterium ulcerans hypothetical protein 0.008 0.0684 0.1286
Leishmania major DNA polymerase kappa, putative 0.0038 0.0264 0.0264
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.008 0.0684 0.1774
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0303 0.0707
Loa Loa (eye worm) oxidoreductase 0.0023 0.0123 0.0327
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0043 0.0315 0.0736
Trichomonas vaginalis flap endonuclease-1, putative 0.0059 0.0482 0.1258
Trypanosoma cruzi DNA polymerase kappa, putative 0.0182 0.17 0.17
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0036 0.0244 0.0624
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0308 0.0308
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0239 0.2272 0.593
Plasmodium falciparum flap endonuclease 1 0.0059 0.0482 0.1258
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.0123 0.0207
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0066 0.0154
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0104 0.0923 0.2153
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0123 0.0123
Leishmania major phosphoglycerate kinase B, cytosolic 0.0388 0.3758 0.3758
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0123 0.0327
Onchocerca volvulus 0.0018 0.007 0.0712
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0315 0.0839
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0303 0.0707
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0254 0.0254
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0012 0.001 0.0027
Trypanosoma cruzi DNA polymerase eta, putative 0.0096 0.0843 0.0843
Brugia malayi Phosphoglycerate kinase 0.0388 0.3758 1
Schistosoma mansoni rotamase 0.0037 0.0263 0.0613
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0151 0.1395 0.3255
Loa Loa (eye worm) ThiF family protein 0.0036 0.0244 0.065
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0123 0.0274
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0308 0.0794
Brugia malayi AMP-binding enzyme family protein 0.008 0.0684 0.1819
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.008 0.0684 0.1286
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0239 0.2272 0.6024
Loa Loa (eye worm) 6-phosphofructokinase 0.0239 0.2272 0.6046
Echinococcus granulosus dna polymerase eta 0.0179 0.1675 0.3908
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.0123 0.0327
Entamoeba histolytica exonuclease, putative 0.0012 0.001 0.0027
Trypanosoma brucei mitochondrial DNA polymerase beta 0.1014 1 1
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0046 0.0046
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0012 0.001 0.0024
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0059 0.0482 0.0482
Brugia malayi XPG I-region family protein 0.0012 0.001 0.0027
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0388 0.3758 1
Entamoeba histolytica acyl-coA synthetase, putative 0.008 0.0684 0.1819
Trypanosoma brucei DNA polymerase kappa, putative 0.0136 0.1246 0.1246
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0104 0.0923 0.2153
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0388 0.3758 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0046 0.0121
Schistosoma mansoni DNA polymerase IV / kappa 0.0038 0.0264 0.0617
Brugia malayi CXXC zinc finger family protein 0.0031 0.0199 0.0529
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) 0.0015 0.004 0.0048
Giardia lamblia DNA damage repair protein 0.0038 0.0264 0.0678
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0303 0.0707
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0303 0.0707
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0303 0.0781
Loa Loa (eye worm) hypothetical protein 0.0314 0.3023 0.8044
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0046 0.0094
Trichomonas vaginalis phosphofructokinase, putative 0.0065 0.0534 0.1396
Brugia malayi SEA domain containing protein 0.0017 0.0057 0.0152
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0317 0.082
Entamoeba histolytica phosphofructokinase, putative 0.0239 0.2272 0.6046
Leishmania major 4-coumarate:coa ligase-like protein 0.008 0.0684 0.0684
Schistosoma mansoni hypothetical protein 0.019 0.1782 0.4158
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0053 0.0414 0.1102
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0121 0.1096 0.2917
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0869 0.0869
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0315 0.0839
Leishmania major DNA polymerase eta, putative 0.0096 0.0843 0.0843
Onchocerca volvulus 0.0017 0.0057 0.0583
Schistosoma mansoni hypothetical protein 0.0018 0.0066 0.0154
Trichomonas vaginalis phosphofructokinase, putative 0.0065 0.0534 0.1396
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0065 0.0534 0.0154
Schistosoma mansoni hypothetical protein 0.019 0.1782 0.4158
Echinococcus multilocularis phosphoglycerate kinase 1 0.0388 0.3758 0.8767
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0055 0.0441 0.0441
Brugia malayi glutaminase DH11.1 0.0306 0.2942 0.783
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0065 0.0534 0.1396
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0104 0.0923 0.2456
Loa Loa (eye worm) voltage-dependent calcium channel 0.0022 0.0106 0.0283
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0096 0.0843 0.2244
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0046 0.0466
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0043 0.0317 0.0845
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0123 0.0327
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0151 0.1395 0.3255
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0123 0.0207
Loa Loa (eye worm) hypothetical protein 0.0388 0.3758 1
Giardia lamblia Phosphoglycerate kinase 0.0388 0.3758 1
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0036 0.0244 0.057
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0046 0.0094
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0036 0.0244 0.057
Entamoeba histolytica acyl-CoA synthetase, putative 0.008 0.0684 0.1819
Brugia malayi AMP-binding enzyme family protein 0.008 0.0684 0.1819
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.0123 0.0301
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0308 0.0819
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0142 0.131 0.131
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0066 0.0154
Loa Loa (eye worm) X11 protein 0.0074 0.0628 0.1672
Loa Loa (eye worm) phosphofructokinase 0.0239 0.2272 0.6046
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0066 0.0154
Schistosoma mansoni cpg binding protein 0.0033 0.0216 0.0505
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0199 0.0529
Loa Loa (eye worm) hypothetical protein 0.0059 0.0483 0.1285
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0123 0.0287
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0013 0.0019 0.0045
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0023 0.0123 0.0274
Loa Loa (eye worm) glutaminase 2 0.0306 0.2942 0.783
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0308 0.0819
Echinococcus granulosus bloom syndrome protein 0.0103 0.0921 0.2148
Loa Loa (eye worm) hypothetical protein 0.0018 0.007 0.0186
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.0123 0.0207
Trypanosoma brucei unspecified product 0.0166 0.1551 0.1551
Onchocerca volvulus 0.0109 0.0979 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0869 0.2312
Echinococcus granulosus voltage dependent calcium channel 0.0104 0.0923 0.2153
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.3154 0.8387
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0182 0.17 0.451
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0388 0.3758 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0037 0.0254 0.0254
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0136 0.1246 0.2367
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.048 0.4675 0.4675
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0039 0.0276 0.0643
Trypanosoma brucei chrX additional, unordered contigs 0.0038 0.0264 0.0264
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.0123 0.0207
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0308 0.0794
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0123 0.0301
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0142 0.131 0.131
Toxoplasma gondii transporter, cation channel family protein 0.0022 0.0106 0.0283
Loa Loa (eye worm) hypothetical protein 0.008 0.0684 0.1819
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0104 0.093 0.2474
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0123 0.0207
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.016 0.1484 0.2825
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0264 0.0703
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0123 0.0207
Loa Loa (eye worm) flap endonuclease-1 0.0059 0.0482 0.1282
Loa Loa (eye worm) hypothetical protein 0.0059 0.0483 0.1285
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0059 0.0482 0.1282
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1014 1 1
Brugia malayi ThiF family protein 0.0036 0.0244 0.065
Schistosoma mansoni hypothetical protein 0.0441 0.4286 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0557 0.13
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0059 0.0483 0.09
Schistosoma mansoni hypothetical protein 0.0038 0.0271 0.0631
Echinococcus granulosus voltage dependent calcium channel 0.0022 0.0106 0.0248
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0303 0.0303
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0055 0.0441 0.0441
Brugia malayi hypothetical protein 0.0071 0.0599 0.1595
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0104 0.093 0.2474
Treponema pallidum fructose-bisphosphate aldolase 0.0327 0.3154 0.8345
Echinococcus multilocularis Helicase RNase D C terminal, HRDC domain 0.0013 0.0021 0.0048
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.008 0.0684 0.1286
Loa Loa (eye worm) hypothetical protein 0.0022 0.0107 0.0284
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0012 0.0009 0.0009
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.0123 0.0207
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0308 0.0308
Schistosoma mansoni SET domain protein 0.0039 0.0276 0.0643
Trypanosoma brucei DNA polymerase eta, putative 0.0179 0.1675 0.1675
Toxoplasma gondii peptidylprolyl isomerase 0.0037 0.0254 0.0676
Echinococcus multilocularis MAM 0.0018 0.007 0.0163
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.0123 0.0301
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0123 0.0207
Toxoplasma gondii exonuclease III APE 0.0043 0.0317 0.0845
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0046 0.0094
Schistosoma mansoni hypothetical protein 0.0018 0.007 0.0163
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0027
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0.0003 0.0009
Echinococcus granulosus Helicase RNase D C terminal HRDC domain 0.0013 0.0021 0.0048
Plasmodium falciparum acyl-CoA synthetase 0.0059 0.0483 0.1261
Onchocerca volvulus 0.0018 0.007 0.0712
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0123 0.0207
Trichomonas vaginalis phosphofructokinase, putative 0.0065 0.0534 0.1396
Trypanosoma brucei unspecified product 0.0083 0.0722 0.0722
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0123 0.0327
Plasmodium vivax flap endonuclease 1, putative 0.0059 0.0482 0.1258
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0123 0.0207
Echinococcus granulosus flap endonuclease 1 0.0059 0.0482 0.1124
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0306 0.0714
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0104 0.0923 0.2153
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.0123 0.0207
Treponema pallidum phosphoglycerate kinase 0.0388 0.3758 1
Toxoplasma gondii 3'-5' exonuclease domain-containing protein 0.0013 0.0021 0.0055
Onchocerca volvulus 0.0023 0.0123 0.1256
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0054 0.0428 0.1115
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0263 0.0674
Schistosoma mansoni hypothetical protein 0.0018 0.0066 0.0154
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0123 0.0207
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0388 0.3758 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0303 0.0303
Echinococcus multilocularis flap endonuclease GEN 1 0.0012 0.001 0.0024
Loa Loa (eye worm) DOMON domain-containing protein 0.0017 0.0057 0.0152
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0123 0.0327
Loa Loa (eye worm) hypothetical protein 0.0018 0.0066 0.0176
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0308 0.0794
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0142 0.131 0.131
Giardia lamblia Sgs1 DNA helicase, putative 0.0043 0.0315 0.0814
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0308 0.0794
Loa Loa (eye worm) hypothetical protein 0.0023 0.0123 0.0327
Giardia lamblia DINP protein human, muc B family 0.0136 0.1246 0.3297
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0017 0.0058 0.0154
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0388 0.3758 0.3758
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0012 0.001 0.001
Echinococcus granulosus MAM 0.0018 0.007 0.0163
Echinococcus granulosus flap endonuclease GEN 1 0.0012 0.001 0.0024
Leishmania major DNA damage repair protein, putative 0.0038 0.0264 0.0264
Mycobacterium ulcerans hypothetical protein 0.0013 0.0021 0.0011
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0043 0.0317 0.074
Brugia malayi hypothetical protein 0.0042 0.0306 0.0814
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.0152
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0043 0.0317 0.0317
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0388 0.3758 1
Schistosoma mansoni hypothetical protein 0.0017 0.0057 0.0133
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.0123 0.0327
Mycobacterium ulcerans 6-phosphofructokinase 0.0239 0.2272 0.434
Schistosoma mansoni alpha glucosidase 0.0042 0.0308 0.0718
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0123 0.0287
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0123 0.0123
Onchocerca volvulus 0.0017 0.0057 0.0583
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0308 0.0718
Schistosoma mansoni hypothetical protein 0.0018 0.007 0.0163
Onchocerca volvulus 0.0017 0.0057 0.0583
Trichomonas vaginalis phosphofructokinase, putative 0.0065 0.0534 0.1396
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0308 0.0819
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0043 0.0317 0.082
Loa Loa (eye worm) hypothetical protein 0.0104 0.0923 0.2456
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.3154 0.8387
Trypanosoma brucei DNA damage repair protein, putative 0.0038 0.0264 0.0264
Loa Loa (eye worm) 3'-5' exonuclease 0.0013 0.0021 0.0055
Echinococcus granulosus geminin 0.019 0.1782 0.4158
Brugia malayi Glycosyl hydrolases family 31 protein 0.0189 0.1773 0.4719
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0054 0.0428 0.0999
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0104 0.0923 0.2153
Plasmodium vivax DNA repair protein REV1, putative 0.0038 0.0264 0.0678
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0059 0.0482 0.0482
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.0123 0.0207
Echinococcus multilocularis voltage dependent calcium channel 0.0104 0.0923 0.2153
Loa Loa (eye worm) hypothetical protein 0.0023 0.0123 0.0327
Giardia lamblia Fructose-bisphosphate aldolase 0.0327 0.3154 0.8387
Loa Loa (eye worm) hypothetical protein 0.008 0.0684 0.1819
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0046 0.0094
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0012 0.001 0.0024
Plasmodium vivax exosome complex exonuclease RRP6, putative 0.0013 0.0021 0.0028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.093 0.2169
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.0123 0.0207
Brugia malayi AMP-binding enzyme family protein 0.008 0.0684 0.1819
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0123 0.0207
Brugia malayi RNA binding protein 0.0151 0.1395 0.3713
Echinococcus granulosus dna polymerase kappa 0.0182 0.17 0.3967
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1014 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0327 0.3154 0.8387
Brugia malayi Protein kinase domain containing protein 0.0018 0.007 0.0186
Echinococcus multilocularis expressed protein 0.0037 0.0263 0.0613
Loa Loa (eye worm) hypothetical protein 0.0059 0.0483 0.1285
Schistosoma mansoni alpha-glucosidase 0.0163 0.1511 0.3526
Leishmania major hypothetical protein, conserved 0.0012 0.001 0.001
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0036 0.0244 0.057
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0003 0.0003
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0037 0.0254 0.0254
Toxoplasma gondii 6-phosphofructokinase 0.0065 0.0534 0.142
Trypanosoma brucei DNA polymerase kappa, putative 0.0182 0.17 0.17
Loa Loa (eye worm) hypothetical protein 0.0016 0.0046 0.0121
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0063 0.0518 0.0518
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0123 0.0123
Schistosoma mansoni alpha-glucosidase 0.0163 0.1511 0.3526
Entamoeba histolytica DNA-repair protein, putative 0.0012 0.001 0.0027
Schistosoma mansoni DNA helicase recq1 0.0043 0.0315 0.0736
Mycobacterium ulcerans DNA polymerase IV 0.0182 0.17 0.3241
Mycobacterium ulcerans hypothetical protein 0.0534 0.5215 1
Echinococcus multilocularis exonuclease 1 0.0012 0.001 0.0024

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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