Detailed information for compound 1731482

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 582.574 | Formula: C29H29F3N6O4
  • H donors: 1 H acceptors: 3 LogP: 4.14 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(c2n1nc(c2)C(F)(F)F)C1=NN(CCCCOc2ccc(cc2)c2n[nH]c(=O)cc2C)C(=O)CC1C
  • InChi: 1S/C29H29F3N6O4/c1-17-14-24(39)33-34-27(17)19-6-8-20(9-7-19)42-13-5-4-12-37-25(40)15-18(2)28(36-37)21-10-11-26(41-3)38-22(21)16-23(35-38)29(30,31)32/h6-11,14,16,18H,4-5,12-13,15H2,1-3H3,(H,33,39)
  • InChiKey: HNXMEAAPFFXTON-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 4B, cAMP-specific Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0112 0.1257 0.3726
Brugia malayi Tubulin alpha chain 0.0008 0.002 0.0059
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0028 0.0251 0.0978
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.0285
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0014 0.0082 0.0076
Echinococcus multilocularis cpg binding protein 0.0031 0.0296 0.0291
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Trypanosoma brucei epsilon tubulin 0.0019 0.0152 0.1092
Brugia malayi Tubulin alpha-2 chain 0.0036 0.0352 0.1382
Schistosoma mansoni tubulin subunit beta 0.0019 0.0152 0.0293
Echinococcus granulosus tubulin beta 4A class IVa 0.0019 0.0152 0.0293
Toxoplasma gondii alpha tubulin TUBA1 0.0036 0.0352 0.1032
Echinococcus granulosus tubulin alpha 3 chain 0.0036 0.0352 0.0694
Trypanosoma cruzi tubulin delta chain 0.0008 0.002 0.011
Leishmania major epsilon tubulin, putative 0.0019 0.0152 0.1092
Trichomonas vaginalis tubulin epsilon chain, putative 0.0036 0.0352 0.1227
Leishmania major gamma-tubulin 0.0019 0.0152 0.1092
Echinococcus granulosus tubulin subunit TubB 0.0036 0.0352 0.0694
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Schistosoma mansoni tubulin subunit delta 0.0008 0.002 0.0029
Trichomonas vaginalis tubulin alpha chain, putative 0.0011 0.0051 0.0178
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.0569
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0298 0.087
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0014 0.0082 0.0285
Plasmodium falciparum tubulin gamma chain 0.0019 0.0152 0.4229
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Trichomonas vaginalis tubulin, putative 0.0011 0.0051 0.0178
Trypanosoma cruzi zeta tubulin, putative 0.0008 0.002 0.011
Schistosoma mansoni tubulin subunit beta 0.0019 0.0152 0.0293
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0008 0.002 0.0071
Schistosoma mansoni hypothetical protein 0.0016 0.0115 0.0219
Brugia malayi PAN domain containing protein 0.0019 0.0141 0.0539
Echinococcus multilocularis tubulin alpha 1C chain 0.0036 0.0352 0.0347
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.2202
Trichomonas vaginalis tubulin beta chain, putative 0.0036 0.0352 0.1227
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0115 0.0437
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0042 0.0419 0.123
Plasmodium falciparum tubulin delta chain, putative 0.0008 0.002 0.0424
Schistosoma mansoni hypothetical protein 0.0016 0.0115 0.0219
Trichomonas vaginalis tubulin beta chain, putative 0.0019 0.0152 0.053
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0115 0.011
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0214 0.083
Giardia lamblia Beta tubulin 0.0019 0.0152 0.1067
Brugia malayi Tubulin gamma chain 0.0019 0.0152 0.0585
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0214 0.183
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.0285
Loa Loa (eye worm) hypothetical protein 0.0112 0.1257 0.4989
Leishmania major alpha tubulin 0.0036 0.0352 0.2583
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0139 0.3856
Brugia malayi tubulin alpha chain - mouse 0.0036 0.0352 0.1382
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0082 0.0569
Leishmania major alpha tubulin 0.0036 0.0352 0.2583
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0276 0.1078
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.083
Trypanosoma brucei beta tubulin 0.0019 0.0152 0.1092
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.1143 0.4534
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0214 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0214 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.1143 0.4534
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.1143 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.2202
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.1668 0.3326
Trichomonas vaginalis tubulin epsilon chain, putative 0.0008 0.002 0.0071
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Brugia malayi hypothetical protein 0.0037 0.0366 0.1438
Echinococcus multilocularis tubulin alpha chain 0.0036 0.0352 0.0347
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0014 0.0082 0.0304
Onchocerca volvulus 0.003 0.0276 0.0944
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0082 0.0569
Schistosoma mansoni tubulin subunit alpha 0.0036 0.0352 0.0694
Brugia malayi PAN domain containing protein 0.0019 0.0141 0.0539
Trypanosoma brucei beta tubulin 0.0019 0.0152 0.1092
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0042 0.0419 0.3077
Trichomonas vaginalis tubulin alpha chain, putative 0.0011 0.0051 0.0178
Schistosoma mansoni pyruvate dehydrogenase 0.0119 0.1348 0.2686
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0014 0.0082 0.0285
Brugia malayi PAN domain containing protein 0.0019 0.0141 0.0539
Plasmodium falciparum alpha tubulin 2 0.0036 0.0352 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0214 0.183
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0539
Leishmania major zeta tubulin, putative 0.0008 0.002 0.011
Echinococcus multilocularis tubulin alpha 0.0019 0.0152 0.0147
Leishmania major alpha tubulin 0.0036 0.0352 0.2583
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0214 0.1551
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0021 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0539
Toxoplasma gondii alpha-tubulin I, putative 0.0036 0.0352 0.1032
Plasmodium vivax tubulin alpha chain, putative 0.0036 0.0352 1
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0444 0.0878
Trypanosoma cruzi alpha tubulin, putative 0.0036 0.0352 0.2583
Echinococcus granulosus tubulin alpha 1C chain 0.0036 0.0352 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0444 0.1547
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0082 0.0569
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0014 0.0082 0.0569
Trichomonas vaginalis tubulin, putative 0.0008 0.002 0.0071
Plasmodium vivax delta tubulin, putative 0.0008 0.002 0.0424
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0112 0.1257 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0014 0.0082 0.0569
Schistosoma mansoni hypothetical protein 0.0042 0.0425 0.084
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0115 0.0219
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Trichomonas vaginalis tubulin beta chain, putative 0.0036 0.0352 0.1227
Echinococcus granulosus tubulin alpha chain 0.0036 0.0352 0.0694
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Mycobacterium tuberculosis Cell division protein FtsZ 0.0008 0.002 0.0706
Toxoplasma gondii microneme protein, putative 0.0019 0.0141 0.0403
Loa Loa (eye worm) hypothetical protein 0.0044 0.0444 0.1749
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0214 1
Loa Loa (eye worm) BEN-1 protein 0.0019 0.0152 0.0585
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0014 0.0082 0.0569
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0139 0.6421
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0014 0.0082 0.0304
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0006 0.002
Schistosoma mansoni hypothetical protein 0.0424 0.5004 1
Echinococcus granulosus Tubulin beta 2C chain 0.0019 0.0152 0.0293
Echinococcus multilocularis tubulin delta chain 0.0008 0.002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0539
Echinococcus granulosus tubulin gamma 1 chain 0.0019 0.0152 0.0293
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Schistosoma mansoni patched 1 0.0044 0.0444 0.0878
Giardia lamblia hypothetical protein 0.0014 0.0082 0.0498
Echinococcus multilocularis tubulin epsilon chain 0.0019 0.0152 0.0147
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0444 0.1749
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0298 0.0293
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.1143 0.2276
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0014 0.0082 0.0569
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.0285
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0609 0.1797
Schistosoma mansoni alpha tubulin 0.0036 0.0352 0.0694
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0025 0.022 0.0768
Loa Loa (eye worm) tubulin beta chain 0.0019 0.0152 0.0585
Leishmania major alpha tubulin 0.0036 0.0352 0.2583
Schistosoma mansoni hypothetical protein 0.0035 0.0343 0.0674
Echinococcus granulosus peroxisome assembly protein 26 0.0036 0.0352 0.0694
Brugia malayi PAN domain containing protein 0.0019 0.0141 0.0539
Leishmania major alpha tubulin 0.0036 0.0352 0.2583
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0021 0.0016
Entamoeba histolytica hypothetical protein 0.0037 0.0366 0.3171
Onchocerca volvulus 0.0019 0.0141 0.0472
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0539 0.2126
Echinococcus multilocularis tubulin subunit beta 0.0019 0.0152 0.0147
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Loa Loa (eye worm) tubulin alpha chain 0.0036 0.0352 0.1382
Loa Loa (eye worm) tubulin beta-1 chain 0.0019 0.0152 0.0585
Trypanosoma brucei zeta tubulin, putative 0.0008 0.002 0.011
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0008 0.002 0.0044
Loa Loa (eye worm) hypothetical protein 0.0025 0.022 0.0856
Brugia malayi Tubulin alpha-2 chain 0.0036 0.0352 0.1382
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0214 0.1551
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0014 0.0082 0.0304
Schistosoma mansoni cpg binding protein 0.003 0.0276 0.0541
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0042 0.0419 0.3077
Trichomonas vaginalis tubulin, putative 0.0011 0.0051 0.0178
Toxoplasma gondii beta tubulin 0.0019 0.0152 0.0437
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0082 0.0569
Trypanosoma brucei alpha tubulin 0.0036 0.0352 0.2583
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0539
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0214 1
Echinococcus multilocularis tubulin alpha chain 0.0036 0.0352 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0082 0.0285
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0115 0.0437
Toxoplasma gondii subtilisin SUB12 0.0019 0.0141 0.0403
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0298 0.0585
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0014 0.0082 0.0076
Trichomonas vaginalis tubulin gamma chain, putative 0.0019 0.0152 0.053
Loa Loa (eye worm) tubulin gamma chain 0.0019 0.0152 0.0585
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Echinococcus multilocularis Tubulin beta 2C chain 0.0019 0.0152 0.0147
Onchocerca volvulus 0.0019 0.0141 0.0472
Plasmodium falciparum tubulin beta chain 0.0019 0.0152 0.4229
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0014 0.0082 0.0304
Schistosoma mansoni tubulin subunit beta 0.0019 0.0152 0.0293
Brugia malayi tubulin alpha-2 chain 0.0036 0.0352 0.1382
Echinococcus multilocularis Tubulin beta 2C chain 0.0019 0.0152 0.0147
Echinococcus granulosus dnaJ subfamily B 0.0424 0.5004 1
Trypanosoma brucei beta tubulin 0.0019 0.0152 0.1092
Schistosoma mansoni hypothetical protein 0.0016 0.0115 0.0219
Leishmania major delta tubulin, putative 0.0008 0.002 0.011
Giardia lamblia Hypothetical protein 0.0014 0.0082 0.0498
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0042 0.0419 0.3077
Plasmodium falciparum alpha tubulin 1 0.0036 0.0352 1
Onchocerca volvulus 0.0032 0.0298 0.102
Loa Loa (eye worm) hypothetical protein 0.0119 0.1348 0.5351
Trichomonas vaginalis tubulin alpha chain, putative 0.0019 0.0152 0.053
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0021 0.0032
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Toxoplasma gondii beta-1 tubulin, putative 0.0019 0.0152 0.0437
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0298 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0082 0.0285
Plasmodium vivax tubulin alpha chain, putative 0.0036 0.0352 1
Echinococcus granulosus tubulin delta chain 0.0008 0.002 0.0029
Plasmodium vivax SET domain protein, putative 0.0032 0.0298 0.8433
Entamoeba histolytica tubulin alpha-1 chain 0.0036 0.0352 0.3048
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0119 0.1348 1
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0141 0.0403
Brugia malayi PAN domain containing protein 0.0019 0.0141 0.0539
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0139 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0343 0.1344
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0014 0.0082 0.0569
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Schistosoma mansoni tubulin subunit epsilon 0.0019 0.0152 0.0293
Loa Loa (eye worm) tubulin beta chain 0.0008 0.002 0.0059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Schistosoma mansoni tubulin subunit alpha 0.0036 0.0352 0.0694
Onchocerca volvulus 0.0019 0.0141 0.0472
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0119 0.1348 0.2686
Mycobacterium ulcerans hypothetical protein 0.0025 0.0214 1
Trypanosoma cruzi epsilon tubulin, putative 0.0019 0.0152 0.1092
Echinococcus multilocularis GPCR, family 2 0.0016 0.0115 0.011
Echinococcus multilocularis Tubulin beta 2C chain 0.0019 0.0152 0.0147
Leishmania major alpha tubulin 0.0036 0.0352 0.2583
Echinococcus granulosus Tubulin alpha 1 chain 0.0036 0.0352 0.0694
Plasmodium vivax tubulin gamma chain, putative 0.0019 0.0152 0.4229
Echinococcus granulosus Tubulin alpha 1 chain 0.0036 0.0352 0.0694
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0298 0.0585
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0014 0.0082 0.0153
Toxoplasma gondii microneme protein MIC4 0.0019 0.0141 0.0403
Treponema pallidum cell division protein FtsZ 0.0008 0.002 0.5
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.2514 1
Echinococcus multilocularis tubulin alpha chain 0.0036 0.0352 0.0347
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Brugia malayi alpha-tubulin 0.0036 0.0352 0.1382
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0115 0.011
Echinococcus multilocularis tubulin alpha 1C chain 0.0036 0.0352 0.0347
Trichomonas vaginalis tubulin beta chain, putative 0.0036 0.0352 0.1227
Loa Loa (eye worm) hypothetical protein 0.0054 0.0563 0.222
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0214 0.083
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0112 0.1257 0.2504
Echinococcus multilocularis expressed conserved protein 0.0096 0.1069 0.1064
Trypanosoma brucei beta tubulin 0.0019 0.0152 0.1092
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.083
Trichomonas vaginalis tubulin gamma chain, putative 0.0019 0.0152 0.053
Echinococcus granulosus Tubulin alpha 1 chain 0.0036 0.0352 0.0694
Echinococcus multilocularis Tubulin alpha 1 chain 0.0036 0.0352 0.0347
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0014 0.0082 0.0569
Loa Loa (eye worm) hypothetical protein 0.0016 0.0115 0.0437
Loa Loa (eye worm) tubulin alpha chain 0.0036 0.0352 0.1382
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.0285
Echinococcus granulosus beta tubulin 0.0019 0.0152 0.0293
Trypanosoma brucei tubulin delta chain 0.0008 0.002 0.011
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0277 0.0542
Trichomonas vaginalis tubulin alpha chain, putative 0.0019 0.0152 0.053
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.0285
Giardia lamblia Beta tubulin 0.0019 0.0152 0.1067
Echinococcus granulosus tubulin alpha chain 0.0036 0.0352 0.0694
Schistosoma mansoni tubulin subunit beta 0.0008 0.002 0.0029
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0048 0.0498 0.1466
Echinococcus multilocularis Tubulin beta 2C chain 0.0019 0.0152 0.0147
Toxoplasma gondii PAN/Apple domain-containing protein 0.0019 0.0141 0.0403
Trypanosoma cruzi zeta tubulin, putative 0.0008 0.002 0.011
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0115 0.0219
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Giardia lamblia Alpha-tubulin 0.0036 0.0352 0.2684
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0082 0.0569
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0014 0.0082 0.0569
Onchocerca volvulus 0.0025 0.0214 0.0726
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Loa Loa (eye worm) alpha-tubulin 0.0036 0.0352 0.1382
Loa Loa (eye worm) tubulin beta-4 chain 0.0019 0.0152 0.0585
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0098 0.1094 0.1089
Trypanosoma brucei zeta tubulin 0.0008 0.002 0.011
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0014 0.0082 0.0153
Loa Loa (eye worm) hypothetical protein 0.0018 0.0139 0.0533
Trypanosoma brucei beta tubulin 0.0019 0.0152 0.1092
Schistosoma mansoni hypothetical protein 0.0042 0.0425 0.084
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Echinococcus multilocularis tubulin alpha chain 0.0036 0.0352 0.0347
Echinococcus granulosus tubulin subunit beta 0.0019 0.0152 0.0293
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Plasmodium vivax tubulin beta chain, putative 0.0019 0.0152 0.4229
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Echinococcus multilocularis tubulin gamma 1 chain 0.0019 0.0152 0.0147
Loa Loa (eye worm) hypothetical protein 0.0014 0.0082 0.0304
Loa Loa (eye worm) histone methyltransferase 0.001 0.0043 0.015
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0082 0.0569
Loa Loa (eye worm) tubulin alpha 2 0.0028 0.0251 0.0978
Trypanosoma brucei alpha tubulin 0.0036 0.0352 0.2583
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0014 0.0082 0.0153
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0444 0.0439
Echinococcus granulosus tubulin alpha chain 0.0036 0.0352 0.0694
Onchocerca volvulus 0.0246 0.2872 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0214 1
Echinococcus multilocularis beta tubulin 0.0019 0.0152 0.0147
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.069 0.1369
Loa Loa (eye worm) tubulin alpha 2 0.0028 0.0251 0.0978
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0539 0.2126
Brugia malayi Tubulin alpha chain 0.0036 0.0352 0.1382
Brugia malayi CHE-14 protein 0.0044 0.0444 0.1749
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0008 0.002 0.0044
Toxoplasma gondii microneme protein MIC17C 0.0019 0.0141 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.002 0.0071
Echinococcus multilocularis tubulin subunit TubB 0.0036 0.0352 0.0347
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0112 0.1257 0.1252
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0014 0.0082 0.0076
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0127 0.5844
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0014 0.0082 0.0076
Plasmodium falciparum phosphodiesterase gamma, putative 0.0014 0.0082 0.2202
Schistosoma mansoni tubulin subunit beta 0.0019 0.0152 0.0293
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0141 0.0539
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Loa Loa (eye worm) beta-tubulin 0.0019 0.0152 0.0585
Onchocerca volvulus 0.0019 0.0141 0.0472
Brugia malayi Cell division protein ftsZ 0.0008 0.002 0.0059
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Leishmania major alpha tubulin 0.0036 0.0352 0.2583
Schistosoma mansoni hypothetical protein 0.0037 0.0366 0.0722
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0014 0.0082 0.0153
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Trichomonas vaginalis tubulin epsilon chain, putative 0.0019 0.0152 0.053
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.1668 0.1664
Echinococcus granulosus tubulin epsilon chain 0.0019 0.0152 0.0293
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Echinococcus multilocularis peroxisome assembly protein 26 0.0036 0.0352 0.0347
Loa Loa (eye worm) PDE1B protein 0.0014 0.0082 0.0304
Echinococcus multilocularis Tubulin alpha 1 chain 0.0036 0.0352 0.0347
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0021 0.0032
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0014 0.0082 0.0569
Brugia malayi PAN domain containing protein 0.0019 0.0141 0.0539
Plasmodium falciparum tubulin epsilon chain, putative 0.0019 0.0152 0.4229
Loa Loa (eye worm) hypothetical protein 0.0028 0.0251 0.0978
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0014 0.0082 0.0285
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.1162 0.2313
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.0285
Brugia malayi beta-tubulin, identical 0.0019 0.0152 0.0585
Loa Loa (eye worm) tubulin alpha 2 0.0017 0.0119 0.0453
Schistosoma mansoni tubulin subunit alpha 0.0036 0.0352 0.0694
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0014 0.0082 0.0153
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0014 0.0082 0.0569
Loa Loa (eye worm) hypothetical protein 0.0025 0.0214 0.083
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.0569
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0043 0.0075
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0139 0.3856
Echinococcus granulosus tubulin beta 1 chain 0.0019 0.0152 0.0293
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Brugia malayi Tubulin beta-1 chain 0.0019 0.0152 0.0585
Brugia malayi PAN domain containing protein 0.0019 0.0141 0.0539
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0014 0.0082 0.0153
Schistosoma mansoni tubulin subunit alpha 0.0008 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0032 0.0298 0.1165
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0214 0.1551
Schistosoma mansoni tubulin subunit beta 0.0019 0.0152 0.0293
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0141 0.0539
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0014 0.0082 0.0153
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.0285
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0214 1
Echinococcus multilocularis hypothetical protein 0.0036 0.0352 0.0347
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0042 0.0144
Mycobacterium leprae cell division protein FtsZ 0.0008 0.002 0.0706
Brugia malayi Tubulin beta chain 0.0008 0.002 0.0059
Schistosoma mansoni pyruvate dehydrogenase 0.0113 0.1269 0.2527
Brugia malayi CXXC zinc finger family protein 0.003 0.0276 0.1078
Echinococcus granulosus cpg binding protein 0.0031 0.0296 0.0582
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0539
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0082 0.0285
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0014 0.0082 0.0153
Entamoeba histolytica tubulin gamma chain 0.0019 0.0152 0.1289
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0006 0.002
Leishmania major alpha tubulin 0.0036 0.0352 0.2583
Echinococcus granulosus Tubulin beta 2C chain 0.0019 0.0152 0.0293
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Leishmania major developmentally regulated phosphoprotein-like protein 0.0119 0.1348 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0014 0.0082 0.0153
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0014 0.0082 0.0153
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0098 0.1094 0.434
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.0285
Giardia lamblia Beta tubulin 0.0019 0.0152 0.1067
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0214 0.083
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0141 0.0539
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.5004 0.5001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Echinococcus granulosus tubulin alpha 0.0019 0.0152 0.0293
Trypanosoma brucei epsilon tubulin 0.0019 0.0152 0.1092
Echinococcus granulosus tubulin alpha chain 0.0036 0.0352 0.0694
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0014 0.0082 0.0304
Onchocerca volvulus 0.0019 0.0141 0.0472
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.2202
Trichomonas vaginalis set domain proteins, putative 0.0246 0.2872 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0014 0.0082 0.2202
Echinococcus granulosus alpha tubulin 0.0036 0.0352 0.0694
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0019 0.0141 0.0403
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0214 1
Leishmania major alpha tubulin 0.0036 0.0352 0.2583
Onchocerca volvulus 0.0011 0.0051 0.0158
Onchocerca volvulus 0.0019 0.0141 0.0472
Trypanosoma brucei epsilon tubulin 0.0019 0.0152 0.1092
Loa Loa (eye worm) tubulin alpha-3 chain 0.0025 0.022 0.0856
Echinococcus granulosus GPCR family 2 0.0016 0.0115 0.0219
Trypanosoma brucei alpha tubulin 0.0036 0.0352 0.2583
Trichomonas vaginalis tubulin beta chain, putative 0.0036 0.0352 0.1227
Trypanosoma brucei tubulin gamma chain 0.0019 0.0152 0.1092
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Echinococcus multilocularis protein patched 0.0044 0.0444 0.0439
Toxoplasma gondii PAN domain-containing protein 0.0287 0.3365 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0014 0.0082 0.2202
Trypanosoma brucei alpha tubulin, putative 0.0011 0.0051 0.0338
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0298 0.0585
Onchocerca volvulus 0.0019 0.0141 0.0472
Echinococcus granulosus tubulin alpha 1C chain 0.0036 0.0352 0.0694
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0112 0.1257 0.2504
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0014 0.0082 0.0304
Leishmania major alpha tubulin 0.0036 0.0352 0.2583
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0082 0.0569
Toxoplasma gondii hypothetical protein 0.0019 0.0141 0.0403
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.0285
Schistosoma mansoni tubulin subunit gamma 0.0019 0.0152 0.0293
Brugia malayi PAN domain containing protein 0.0019 0.0141 0.0539
Trichomonas vaginalis tubulin alpha chain, putative 0.0011 0.0051 0.0178
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0014 0.0082 0.0153
Onchocerca volvulus 0.0019 0.0141 0.0472
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0298 0.0585
Loa Loa (eye worm) hypothetical protein 0.0014 0.0082 0.0304
Brugia malayi Pre-SET motif family protein 0.0216 0.2514 1
Schistosoma mansoni hypothetical protein 0.0016 0.0115 0.0219
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.0285
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0141 0.0539
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0021 0.0032
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0014 0.0082 0.0569
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0214 1
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0141 0.0403
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0214 0.183
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0141 0.0403
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0115 0.0437
Echinococcus multilocularis Tubulin beta 2C chain 0.0019 0.0152 0.0147
Leishmania major hypothetical protein, conserved 0.0014 0.0082 0.0569
Loa Loa (eye worm) hypothetical protein 0.0014 0.0082 0.0304
Brugia malayi PAN domain containing protein 0.0019 0.0141 0.0539
Loa Loa (eye worm) hypothetical protein 0.0018 0.0139 0.0533
Entamoeba histolytica tubulin alpha chain, putative 0.0036 0.0352 0.3048
Schistosoma mansoni hypothetical protein 0.0042 0.0425 0.084
Mycobacterium ulcerans cell division protein FtsZ 0.0008 0.002 0.0706
Brugia malayi kinase, mitochondrial precursor 0.0119 0.1348 0.5351
Loa Loa (eye worm) alpha-tubulin 0.0036 0.0352 0.1382
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0014 0.0082 0.0569
Trichomonas vaginalis tubulin beta chain, putative 0.0036 0.0352 0.1227
Onchocerca volvulus 0.0019 0.0141 0.0472
Loa Loa (eye worm) hypothetical protein 0.0052 0.0539 0.2126
Leishmania major hypothetical protein, conserved 0.0014 0.0082 0.0569
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0014 0.0082 0.0304
Trypanosoma cruzi tubulin gamma chain 0.0019 0.0152 0.1092
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.0285
Loa Loa (eye worm) tubulin alpha-2 chain 0.0036 0.0352 0.1382
Trypanosoma cruzi epsilon tubulin, putative 0.0019 0.0152 0.1092
Entamoeba histolytica hypothetical protein 0.0037 0.0366 0.3171
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.0285
Echinococcus multilocularis protein dispatched 1 0.005 0.0519 0.0513
Giardia lamblia Alpha-tubulin 0.0036 0.0352 0.2684
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Trypanosoma cruzi tubulin delta chain 0.0008 0.002 0.011
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0141 0.0403
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0539 0.2126
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.1143 0.1138
Brugia malayi Tubulin beta chain 0.0011 0.0051 0.0181
Echinococcus multilocularis beta tubulin 0.0019 0.0152 0.0147
Trichomonas vaginalis tubulin epsilon chain, putative 0.0019 0.0152 0.053
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0008 0.002 0.5
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0028 0.0251 0.0874
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0014 0.0082 0.0227
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0112 0.1257 0.2504
Trypanosoma brucei developmentally regulated phosphoprotein 0.0119 0.1348 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.0285
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0014 0.0082 0.0076
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0014 0.0082 0.0569
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.2202
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0014 0.0082 0.0569
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0127 0.5844
Toxoplasma gondii microneme protein MIC17B 0.0019 0.0141 0.0403
Brugia malayi PAN domain containing protein 0.0019 0.0141 0.0539
Toxoplasma gondii beta-tubulin, putative 0.0019 0.0152 0.0437
Onchocerca volvulus 0.0019 0.0141 0.0472
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0139 0.6421
Plasmodium vivax tubulin epsilon chain, putative 0.0019 0.0152 0.4229
Loa Loa (eye worm) hypothetical protein 0.0036 0.0352 0.1382
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0098 0.1094 0.2178
Loa Loa (eye worm) hypothetical protein 0.0018 0.0139 0.0533
Echinococcus multilocularis tubulin alpha chain 0.0036 0.0352 0.0347
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0019 0.0152 0.0147
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0043 0.0038
Trichomonas vaginalis tubulin beta chain, putative 0.0011 0.0051 0.0178
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0298 0.0293
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0098 0.1094 0.434
Onchocerca volvulus 0.0019 0.0141 0.0472
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0036 0.0352 0.1227
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Loa Loa (eye worm) tubulin beta-2A chain 0.0019 0.0152 0.0585
Entamoeba histolytica tubulin family protein 0.0019 0.0152 0.1289
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0214 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0119 0.1348 0.1343
Schistosoma mansoni tubulin subunit beta 0.0019 0.0152 0.0293
Echinococcus multilocularis tubulin alpha 3 chain 0.0036 0.0352 0.0347
Schistosoma mansoni alpha tubulin 0.0036 0.0352 0.0694
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0014 0.0082 0.0076
Giardia lamblia Gamma tubulin 0.0019 0.0152 0.1067
Plasmodium falciparum phosphodiesterase delta, putative 0.0014 0.0082 0.2202
Schistosoma mansoni cpg binding protein 0.0031 0.0296 0.0582
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Loa Loa (eye worm) hypothetical protein 0.0018 0.0139 0.0533
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0141 0.0539
Schistosoma mansoni cpg binding protein 0.0031 0.0296 0.0582
Schistosoma mansoni alpha tubulin 0.0036 0.0352 0.0694
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0444 0.0878
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.002 0.0071
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0366 0.0722
Echinococcus granulosus Tubulin beta 2C chain 0.0019 0.0152 0.0293
Toxoplasma gondii PAN domain-containing protein 0.0287 0.3365 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0008 0.002 0.0071
Schistosoma mansoni hypothetical protein 0.0042 0.0425 0.084
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0011 0.0051 0.0178
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0014 0.0082 0.0153
Echinococcus multilocularis tubulin beta 1 chain 0.0019 0.0152 0.0147
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0366 0.0361
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0014 0.0082 0.0153
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Toxoplasma gondii microneme protein MIC17A 0.0019 0.0141 0.0403
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0127 0.5844
Echinococcus granulosus tubulin alpha 3 chain 0.0036 0.0352 0.0694
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0214 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0343 0.1344
Echinococcus granulosus Tubulin beta 2C chain 0.0019 0.0152 0.0293
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0014 0.0082 0.0569
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0539
Trichomonas vaginalis tubulin gamma chain, putative 0.0019 0.0152 0.053
Echinococcus granulosus Tubulin beta 2C chain 0.0019 0.0152 0.0293
Leishmania major beta tubulin 0.0019 0.0152 0.1092
Loa Loa (eye worm) BEN-1 protein 0.0019 0.0152 0.0585
Entamoeba histolytica hypothetical protein 0.0037 0.0366 0.3171
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0127 0.5844
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0019 0.0152 0.0437
Trichomonas vaginalis tubulin epsilon chain, putative 0.0036 0.0352 0.1227
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0014 0.0082 0.2202
Entamoeba histolytica tubulin family protein 0.0019 0.0152 0.1289
Echinococcus multilocularis Tubulin alpha 1 chain 0.0036 0.0352 0.0347
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0366 0.0722
Loa Loa (eye worm) hypothetical protein 0.0019 0.0141 0.0539
Toxoplasma gondii hypothetical protein 0.0019 0.0141 0.0403
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.0285
Schistosoma mansoni pyruvate dehydrogenase 0.0113 0.1269 0.2527
Loa Loa (eye worm) hypothetical protein 0.0018 0.0139 0.0533
Trypanosoma brucei alpha tubulin 0.0036 0.0352 0.2583
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0214 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0112 0.1257 0.1252
Echinococcus granulosus expressed conserved protein 0.0096 0.1069 0.2127
Trichomonas vaginalis tubulin beta chain, putative 0.0036 0.0352 0.1227
Entamoeba histolytica hypothetical protein 0.0037 0.0366 0.3171
Brugia malayi Pre-SET motif family protein 0.0032 0.0298 0.1165
Trypanosoma cruzi beta tubulin, putative 0.0019 0.0152 0.1092
Echinococcus multilocularis tubulin alpha 3 chain 0.0036 0.0352 0.0347
Leishmania major alpha tubulin 0.0036 0.0352 0.2583
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0082 0.0285
Trichomonas vaginalis tubulin, putative 0.0019 0.0152 0.053
Echinococcus granulosus beta tubulin 0.0019 0.0152 0.0293
Leishmania major alpha tubulin 0.0036 0.0352 0.2583
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0082 0.2202
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0119 0.1348 0.1343
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0014 0.0082 0.0153
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0014 0.0082 0.0153
Echinococcus granulosus tubulin alpha chain 0.0036 0.0352 0.0694
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0014 0.0082 0.0153

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6 nM Inhibition of PDE4B (unknown origin) by radiochemical assay ChEMBL. 23200255
IC50 (binding) = 40000 nM Inhibition of PDE3A (unknown origin) by radiochemical assay ChEMBL. 23200255

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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