Detailed information for compound 173435

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 529.714 | Formula: C27H35N3O4S2
  • H donors: 3 H acceptors: 5 LogP: 5.25 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(NC(=O)C1(CCCC1)NC(=O)[C@H](CC1CCCCC1)S)Cc1ccc(nc1)c1cscc1
  • InChi: 1S/C27H35N3O4S2/c31-24(23(35)15-18-6-2-1-3-7-18)30-27(11-4-5-12-27)26(34)29-22(25(32)33)14-19-8-9-21(28-16-19)20-10-13-36-17-20/h8-10,13,16-18,22-23,35H,1-7,11-12,14-15H2,(H,29,34)(H,30,31)(H,32,33)/t22?,23-/m0/s1
  • InChiKey: SRCXNJMRCQLQHK-WCSIJFPASA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens endothelin converting enzyme 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Toxoplasma gondii peptidase family M13 protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium ulcerans zinc metalloprotease Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma japonicum ko:K01415 endothelin-converting enzyme [EC3.4.24.71], putative Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma japonicum IPR000718,Peptidase M13, neprilysin,domain-containing Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Echinococcus granulosus endothelin converting enzyme 1 Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Onchocerca volvulus Get druggable targets OG5_127344 All targets in OG5_127344
Neospora caninum hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma mansoni family M13 unassigned peptidase (M13 family) Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium leprae probable zinc metalloprotease Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Echinococcus multilocularis endothelin converting enzyme 1 Get druggable targets OG5_127344 All targets in OG5_127344
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Brugia malayi Peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0058 0.037 0.037
Echinococcus multilocularis ring and YY1 binding protein 0.0292 0.2105 0.2105
Schistosoma mansoni smad1 5 8 and 0.0016 0.0064 0.0064
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0004 0.0004
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0114 0.0787 0.1308
Schistosoma mansoni peter pan-related 0.0015 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0091
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0208 0.2296
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0064 0.0064
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.2886 0.2886
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0055 0.0055
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0208 0.0943
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0208 0.0345
Trypanosoma cruzi hypothetical protein, conserved 0.0292 0.2105 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0208 0.0345
Echinococcus multilocularis SWI:SNF matrix associated 0.0822 0.6016 0.6016
Giardia lamblia Kinase, NEK 0.0015 0.0055 1
Brugia malayi Pre-SET motif family protein 0.0206 0.1468 0.244
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0292 0.2105 0.3498
Onchocerca volvulus 0.0198 0.1407 0.2268
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0128 0.0451
Brugia malayi Pre-SET motif family protein 0.003 0.0167 0.0278
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0208 0.0345
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0208 0.0208
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0292 0.2105 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Schistosoma mansoni hypothetical protein 0.0015 0.0055 0.0055
Leishmania major hypothetical protein, conserved 0.0015 0.0055 0.0096
Trichomonas vaginalis esterase, putative 0.0036 0.0208 0.0345
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.006 0.0122
Echinococcus multilocularis RING finger protein 185 0.0015 0.0055 0.0055
Schistosoma mansoni rnf5 0.0015 0.0055 0.0055
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0822 0.6016 1
Loa Loa (eye worm) hypothetical protein 0.0292 0.2105 0.3498
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0208 0.0345
Loa Loa (eye worm) hypothetical protein 0.0036 0.0208 0.0345
Echinococcus multilocularis ring finger protein 170 0.0015 0.0055 0.0055
Mycobacterium ulcerans lipase LipD 0.0036 0.0208 0.2296
Loa Loa (eye worm) hypothetical protein 0.0198 0.1407 0.2339
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0055 0.0096
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0208 0.0943
Toxoplasma gondii ABC1 family protein 0.0036 0.0208 0.0256
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.006 0.0122
Echinococcus multilocularis tumor protein p63 0.1353 0.9932 0.9932
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0208 0.0834
Mycobacterium ulcerans beta-lactamase 0.0036 0.0208 0.2296
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0155 0.0155
Brugia malayi MH1 domain containing protein 0.0016 0.0064 0.0106
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0208 0.0345
Schistosoma mansoni cpg binding protein 0.003 0.0163 0.0163
Leishmania major hypothetical protein, conserved 0.0015 0.0055 0.0096
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Onchocerca volvulus 0.0056 0.0362 0.0515
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0128 0.0451
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Schistosoma mansoni RNA binding protein 0.0292 0.2105 0.2105
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0167 0.0167
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Echinococcus granulosus cell growth regulator with ring finger domain 0.0015 0.0055 0.0055
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0091
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0015 0.0055 0.0055
Brugia malayi hypothetical protein 0.0015 0.0055 0.0091
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Echinococcus granulosus geminin 0.0165 0.1164 0.1164
Leishmania major hypothetical protein, unknown function 0.0015 0.0055 0.0096
Loa Loa (eye worm) hypothetical protein 0.0036 0.0208 0.0345
Schistosoma mansoni fusion 0.0292 0.2105 0.2105
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.006 0.01
Leishmania major hypothetical protein, conserved 0.0292 0.2105 1
Schistosoma mansoni neprilysin-2 (M13 family) 0.0058 0.037 0.037
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0058 0.037 0.037
Schistosoma mansoni hypothetical protein 0.003 0.0165 0.0165
Leishmania major hypothetical protein, conserved 0.0015 0.0055 0.0096
Schistosoma mansoni ring finger protein 151 0.0015 0.0055 0.0055
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0822 0.6016 1
Echinococcus multilocularis smad 0.0016 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0033 0.0186 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Loa Loa (eye worm) RING finger protein 20 0.0015 0.0055 0.0091
Brugia malayi isocitrate dehydrogenase 0.0016 0.006 0.01
Schistosoma mansoni smad1 5 8 and 0.0016 0.0064 0.0064
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0128 0.0123
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0208 0.0256
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0064 0.0064
Trypanosoma brucei ring finger containing protein 0.0015 0.0055 0.0096
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0015 0.0055 0.0091
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1678 0.2789
Schistosoma mansoni hypothetical protein 0.0398 0.2886 0.2886
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0208 0.0345
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0208 0.0834
Loa Loa (eye worm) hypothetical protein 0.0292 0.2105 0.3498
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0292 0.2105 1
Schistosoma mansoni hypothetical protein 0.0035 0.0207 0.0207
Onchocerca volvulus 0.0036 0.0208 0.0256
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0167 0.0167
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Leishmania major hypothetical protein, conserved 0.0025 0.0128 0.0451
Onchocerca volvulus 0.0822 0.6016 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.006 0.0009
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0204 0.034
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0391 0.0391
Onchocerca volvulus 0.0292 0.2105 0.3438
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.015 0.015
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Schistosoma mansoni zinc finger protein 0.0015 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0091
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0091
Trypanosoma cruzi WLM domain containing protein, putative 0.0292 0.2105 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0278
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0015 0.0055 0.0055
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.006 0.006
Echinococcus granulosus zinc finger protein Ran binding 0.0292 0.2105 0.2105
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Echinococcus multilocularis zinc finger protein Ran binding 0.0292 0.2105 0.2105
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0292 0.2105 0.3498
Brugia malayi Cytochrome P450 family protein 0.0012 0.0035 0.0058
Mycobacterium ulcerans hypothetical protein 0.0036 0.0208 0.2296
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0382 0.4609
Toxoplasma gondii ran binding protein 0.0292 0.2105 0.3438
Brugia malayi hypothetical protein 0.0016 0.0063 0.0105
Schistosoma mansoni hypothetical protein 0.0292 0.2105 0.2105
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0015 0.0055 0.0091
Echinococcus granulosus Zinc finger RanBP2 type 0.0292 0.2105 0.2105
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0091
Brugia malayi B-box zinc finger family protein 0.0015 0.0055 0.0091
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0822 0.6016 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0015 0.0055 0.0091
Trypanosoma brucei DNA repair protein, putative 0.0015 0.0055 0.0096
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0064 0.0064
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0822 0.6016 0.6016
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0028 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0084 0.0567 0.0943
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0015 0.0055 0.0091
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0382 0.0382
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0292 0.2105 0.3438
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0064 0.0064
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0208 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Loa Loa (eye worm) brahma associated protein 0.0822 0.6016 1
Brugia malayi MH1 domain containing protein 0.0009 0.0011 0.0018
Schistosoma mansoni hypothetical protein 0.0822 0.6016 0.6016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0382 0.4609
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0028 0.015 0.015
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0344 0.0485
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0035 0.0058
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0015 0.0055 0.0091
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Loa Loa (eye worm) beta-lactamase 0.0036 0.0208 0.0345
Schistosoma mansoni cpg binding protein 0.003 0.0163 0.0163
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0382 0.1675
Brugia malayi hypothetical protein 0.0147 0.1032 0.1715
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.006 0.006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0382 0.4609
Schistosoma mansoni hypothetical protein 0.003 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0114 0.0787 0.1308
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0015 0.0055 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0292 0.2105 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0026 0.0042
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.006 0.0122
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0064 0.0106
Brugia malayi MH2 domain containing protein 0.0236 0.1685 0.28
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Brugia malayi Peptidase family M13 containing protein 0.0114 0.0787 0.1308
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0015 0.0055 0.0055
Entamoeba histolytica hypothetical protein 0.0035 0.0207 1
Loa Loa (eye worm) zinc metallopeptidase 4 0.0028 0.015 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Mycobacterium tuberculosis Conserved protein 0.0036 0.0208 0.0943
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Schistosoma mansoni hypothetical protein 0.003 0.0165 0.0165
Echinococcus multilocularis 0.0015 0.0055 0.0055
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1468 0.244
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Brugia malayi MH2 domain containing protein 0.0016 0.0064 0.0106
Trichomonas vaginalis ankyrin, putative 0.0015 0.0055 0.0091
Brugia malayi hypothetical protein 0.0015 0.0055 0.0091
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0035 0.0058
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Loa Loa (eye worm) hypothetical protein 0.0025 0.0128 0.0213
Entamoeba histolytica hypothetical protein 0.0035 0.0207 1
Leishmania major hypothetical protein, conserved 0.0292 0.2105 1
Echinococcus granulosus RING finger protein 185 0.0015 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0147 0.1032 0.1715
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0208 0.0208
Brugia malayi hypothetical protein 0.0015 0.0055 0.0091
Schistosoma mansoni hypothetical protein 0.0822 0.6016 0.6016
Loa Loa (eye worm) Smad1 0.0016 0.0064 0.0106
Echinococcus granulosus neuropeptide receptor A26 0.045 0.327 0.327
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0167 0.0167
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0208 0.2296
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0382 0.0382
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Schistosoma mansoni mind bomb 0.0015 0.0055 0.0055
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0084 0.0567 0.0943
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0064 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0055 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0208 0.0834
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0292 0.2105 0.2105
Brugia malayi RING finger protein 20 0.0015 0.0055 0.0091
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.079 0.5776 0.5776
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0004 0.0004
Echinococcus granulosus endothelin converting enzyme 1 0.0114 0.0787 0.0787
Schistosoma mansoni brg-1 associated factor 0.0822 0.6016 0.6016
Echinococcus granulosus tumor protein p63 0.1353 0.9932 0.9932
Onchocerca volvulus 0.0292 0.2105 0.3438
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0015 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0167 0.0167
Brugia malayi hypothetical protein 0.0035 0.0207 0.0344
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0058 0.037 0.037
Schistosoma mansoni hypothetical protein 0.003 0.0165 0.0165
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0015 0.0055 0.0055
Trypanosoma brucei hypothetical protein, conserved 0.0292 0.2105 1
Brugia malayi Cytochrome P450 family protein 0.0012 0.0035 0.0058
Schistosoma mansoni hypothetical protein 0.003 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0036 0.0208 0.0345
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.1623 1
Leishmania major hypothetical protein, conserved 0.0015 0.0055 0.0096
Echinococcus granulosus cpg binding protein 0.003 0.0163 0.0163
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0035 0.0058
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0292 0.2105 0.3438
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Trypanosoma cruzi hypothetical protein 0.0015 0.0055 0.0096
Echinococcus multilocularis SWI:SNF matrix associated 0.0822 0.6016 0.6016
Leishmania major hypothetical protein, conserved 0.0015 0.0055 0.0096
Schistosoma mansoni hypothetical protein 0.0015 0.0055 0.0055
Mycobacterium tuberculosis Conserved protein 0.0036 0.0208 0.0943
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0055 0.0096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0167 0.0167
Echinococcus granulosus Smad4 0.0016 0.0064 0.0064
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0015 0.0055 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Leishmania major hypothetical protein, conserved 0.0015 0.0055 0.0096
Onchocerca volvulus 0.0147 0.1032 0.1638
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0208 0.0943
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0207 0.0207
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.015 0.015
Echinococcus multilocularis neuropeptide s receptor 0.045 0.327 0.327
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0208 0.0345
Loa Loa (eye worm) peptidase family M13 containing protein 0.0084 0.0567 0.0943
Plasmodium vivax SET domain protein, putative 0.003 0.0167 0.0189
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0015 0.0055 0.0055
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Loa Loa (eye worm) hypothetical protein 0.0292 0.2105 0.3498
Leishmania major hypothetical protein, conserved 0.0015 0.0055 0.0096
Loa Loa (eye worm) hypothetical protein 0.0056 0.0362 0.0602
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0055 0.0096
Brugia malayi peptidase family M13 containing protein 0.0028 0.015 0.025
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0128 0.0123
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0208 0.0943
Leishmania major hypothetical protein, conserved 0.0015 0.0055 0.0096
Onchocerca volvulus 0.0292 0.2105 0.3438
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0114 0.0787 0.465
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0015 0.0055 0.0096
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0015 0.0055 0.0055
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0114 0.0787 0.0787
Leishmania major hypothetical protein, conserved 0.0036 0.0208 0.0834
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0292 0.2105 1
Brugia malayi hypothetical protein 0.0025 0.0128 0.0213
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0382 0.0382
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0015 0.0055 0.0096
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0223 0.037
Brugia malayi MH1 domain containing protein 0.0016 0.0064 0.0106
Echinococcus multilocularis SWI:SNF matrix associated 0.0822 0.6016 0.6016
Brugia malayi brahma associated protein 60 kDa 0.0822 0.6016 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0004 0.0004
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0015 0.0055 0.0091
Leishmania major hypothetical protein, conserved 0.0015 0.0055 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0091
Loa Loa (eye worm) hypothetical protein 0.0036 0.0208 0.0345
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0208 0.0943
Leishmania major DNA repair protein-like protein 0.0015 0.0055 0.0096
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0167 0.0167
Trichomonas vaginalis hypothetical protein 0.0015 0.0055 0.0091
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0248 0.0248
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0822 0.6016 1
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0016 0.0027
Trypanosoma cruzi WLM domain containing protein, putative 0.0292 0.2105 1
Trypanosoma cruzi hypothetical protein, conserved 0.0292 0.2105 1
Schistosoma mansoni neprilysin 0.003 0.0165 0.0165
Onchocerca volvulus 0.0036 0.0208 0.0256
Brugia malayi brahma associated protein 60 kDa 0.0822 0.6016 1
Schistosoma mansoni hypothetical protein 0.0822 0.6016 0.6016
Mycobacterium tuberculosis Conserved protein 0.0036 0.0208 0.0943
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0114 0.0787 0.1308
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0292 0.2105 1
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0042
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Chlamydia trachomatis SWIB complex protein 0.0822 0.6016 0.5
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Echinococcus multilocularis cpg binding protein 0.003 0.0163 0.0163
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0292 0.2105 0.3498
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0208 0.0208
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0292 0.2105 0.2105
Echinococcus multilocularis neuropeptide receptor A26 0.045 0.327 0.327
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0015 0.0055 0.0096
Trichomonas vaginalis ion channel nompc, putative 0.0015 0.0055 0.0091
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0822 0.6016 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0567 0.0943
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0015 0.0055 0.0096
Leishmania major hypothetical protein, conserved 0.0015 0.0055 0.0096
Brugia malayi Zinc finger protein 183 homolog 0.0015 0.0055 0.0091
Loa Loa (eye worm) hypothetical protein 0.0114 0.0787 0.1308
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.006 0.006
Brugia malayi MH1 domain containing protein 0.0009 0.0011 0.0018
Loa Loa (eye worm) hypothetical protein 0.0036 0.0208 0.0345
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0128 0.0123
Echinococcus multilocularis microtubule associated protein 2 0.1362 1 1
Mycobacterium leprae probable zinc metalloprotease 0.0114 0.0787 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0204 0.034
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.1685 0.28
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0004 0.0004
Toxoplasma gondii peptidase family M13 protein 0.0114 0.0787 0.1228
Loa Loa (eye worm) hypothetical protein 0.0086 0.0582 0.0967
Loa Loa (eye worm) hypothetical protein 0.0086 0.0582 0.0967
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0292 0.2105 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0582 0.0967
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Brugia malayi beta-lactamase family protein 0.0036 0.0208 0.0345
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.006 0.0009
Loa Loa (eye worm) RiNg Finger protein family member 0.0015 0.0055 0.0091
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.006 0.0122
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0015 0.0055 0.0091
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Leishmania major hypothetical protein, conserved 0.0292 0.2105 1
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0026 0.0026
Echinococcus multilocularis ring finger protein 113a 0.0015 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0165 0.1164 0.1164
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0026 0.0026
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0055 0.0096
Onchocerca volvulus 0.003 0.0167 0.0189
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0015
Brugia malayi SWIB/MDM2 domain containing protein 0.0822 0.6016 1
Onchocerca volvulus 0.0036 0.0208 0.0256
Trichomonas vaginalis ankyrin, putative 0.0015 0.0055 0.0091
Schistosoma mansoni microtubule-associated protein tau 0.1362 1 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0292 0.2105 0.3498
Loa Loa (eye worm) hypothetical protein 0.0086 0.0582 0.0967
Brugia malayi hypothetical protein 0.0015 0.0055 0.0091
Brugia malayi Smad1 0.0016 0.0064 0.0106
Loa Loa (eye worm) hypothetical protein 0.0086 0.0582 0.0967
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0382 0.2056
Echinococcus granulosus neuropeptide s receptor 0.045 0.327 0.327
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Brugia malayi Zinc finger, C2H2 type family protein 0.0015 0.0055 0.0091
Loa Loa (eye worm) peptidase family M13 containing protein 0.0084 0.0567 0.0943
Trypanosoma cruzi hypothetical protein 0.0015 0.0055 0.0096
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0292 0.2105 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0091
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0015 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0165 0.1164 0.1164
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.015 0.015
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.006 0.006
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Leishmania major hypothetical protein, conserved 0.0015 0.0055 0.0096
Loa Loa (eye worm) hypothetical protein 0.0084 0.0567 0.0943
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0223 0.037
Giardia lamblia Ser/Thr protein kinase 0.0015 0.0055 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Echinococcus granulosus ring finger protein 113a 0.0015 0.0055 0.0055
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Brugia malayi YY1-associated factor 2 0.0292 0.2105 0.3498
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0091
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Echinococcus multilocularis geminin 0.0165 0.1164 0.1164
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Schistosoma mansoni hypothetical protein 0.003 0.0165 0.0165
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0822 0.6016 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0152 0.0252
Brugia malayi RING zinc finger protein 0.0015 0.0055 0.0091
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Brugia malayi MH2 domain containing protein 0.0016 0.0064 0.0106
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0091
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Leishmania major hypothetical protein, conserved 0.0292 0.2105 1
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0015 0.0055 0.0091
Leishmania major hypothetical protein 0.0015 0.0055 0.0096
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0382 0.0382
Leishmania major hypothetical protein, conserved 0.0015 0.0055 0.0096
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.006 0.0122
Schistosoma mansoni hypothetical protein 0.0015 0.0055 0.0055
Echinococcus granulosus ring finger protein 170 0.0015 0.0055 0.0055
Schistosoma mansoni peter pan-related 0.0015 0.0055 0.0055
Leishmania major hypothetical protein, conserved 0.0292 0.2105 1
Schistosoma mansoni cpg binding protein 0.0028 0.0152 0.0152
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Onchocerca volvulus 0.0028 0.0152 0.0162
Schistosoma mansoni smad 0.0016 0.0064 0.0064
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0207 0.0207
Schistosoma mansoni smad1 5 8 and 0.0016 0.0064 0.0064
Schistosoma mansoni Smad4 0.0016 0.0064 0.0064
Brugia malayi beta-lactamase 0.0036 0.0208 0.0345
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0292 0.2105 0.3438
Loa Loa (eye worm) hypothetical protein 0.0086 0.0582 0.0967
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0822 0.6016 0.6016
Loa Loa (eye worm) histone methyltransferase 0.001 0.0017 0.0028
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Brugia malayi beta-lactamase family protein 0.0036 0.0208 0.0345
Trypanosoma brucei hypothetical protein, conserved 0.0292 0.2105 1
Entamoeba histolytica hypothetical protein 0.0035 0.0207 1
Brugia malayi Neuralized family protein 0.0015 0.0055 0.0091
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.1685 0.28
Mycobacterium ulcerans zinc metalloprotease 0.0114 0.0787 1
Trypanosoma brucei predicted zinc finger protein 0.0015 0.0055 0.0096
Onchocerca volvulus 0.0235 0.1678 0.2722
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0091
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0026 0.0026
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Schistosoma mansoni TRABID protein (C64 family) 0.0292 0.2105 0.2105
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0292 0.2105 0.3498
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0015 0.0055 0.0055
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0208 0.0943
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0058 0.037 0.037
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0382 0.0548
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0223 0.0223
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0167 0.0189
Schistosoma mansoni cellular tumor antigen P53 0.0198 0.1407 0.1407
Entamoeba histolytica hypothetical protein 0.0035 0.0207 1
Echinococcus granulosus SWI:SNF matrix associated 0.0822 0.6016 0.6016
Echinococcus granulosus dnaJ subfamily B 0.0398 0.2886 0.2886
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0026 0.0026
Loa Loa (eye worm) nuclear factor I 0.0009 0.0011 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0055 0.0096
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0208 0.0345
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Leishmania major hypothetical protein, conserved 0.0015 0.0055 0.0096
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0015 0.0055 0.0091
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0207 0.0207
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0015 0.0055 0.0055
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0223 0.0223
Echinococcus multilocularis endothelin converting enzyme 1 0.0114 0.0787 0.0787
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0208 0.0943
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.006 0.006
Echinococcus granulosus smad 0.0016 0.0064 0.0064
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.006 0.006
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0248 0.0248
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.006 0.0009
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0822 0.6016 1
Loa Loa (eye worm) hypothetical protein 0.0292 0.2105 0.3498
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0292 0.2105 1
Brugia malayi Isocitrate dehydrogenase 0.0016 0.006 0.01
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0026 0.0026
Brugia malayi hypothetical protein 0.0015 0.0055 0.0091
Schistosoma mansoni endothelin-converting enzyme-related 0.0028 0.015 0.015
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0128 0.0451
Schistosoma mansoni hypothetical protein 0.0011 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0017 0.0017
Echinococcus granulosus ring and YY1 binding protein 0.0292 0.2105 0.2105
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.003 0.0165 0.0165
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0292 0.2105 0.2105
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0152 0.0252
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0015 0.0055 0.0055
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Plasmodium vivax hypothetical protein, conserved 0.0822 0.6016 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0128 0.0123
Schistosoma mansoni zinc finger protein 0.0292 0.2105 0.2105
Brugia malayi hypothetical protein 0.0015 0.0055 0.0091
Onchocerca volvulus 0.0292 0.2105 0.3438
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0167 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0055 0.0091
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0015 0.0055 0.0055
Echinococcus multilocularis Smad4 0.0016 0.0064 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0055 0.0096
Trichomonas vaginalis ankyrin, putative 0.0015 0.0055 0.0091
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0027 0.0027
Chlamydia trachomatis DNA topoisomerase I 0.0822 0.6016 0.5
Giardia lamblia Protein 21.1 0.0015 0.0055 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0015 0.0055 0.0096

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.638 Inhibition of Homo sapiens (human) endothelin converting enzyme-1 ChEMBL. No reference
IC50 (binding) = 23 nM In vitro inhibition of Endothelin-converting enzyme 1. ChEMBL. 12372501
IC50 (binding) = 23 nM In vitro inhibition of Endothelin-converting enzyme 1. ChEMBL. 12372501

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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