Detailed information for compound 1736139

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 462.544 | Formula: C25H30N6O3
  • H donors: 1 H acceptors: 4 LogP: 2.77 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)c1cccc(c1)c1ccc2c(n1)nc(nc2N1CCOC[C@@H]1C)N1CCOC[C@@H]1C
  • InChi: 1S/C25H30N6O3/c1-16-14-33-11-9-30(16)23-20-7-8-21(18-5-4-6-19(13-18)24(32)26-3)27-22(20)28-25(29-23)31-10-12-34-15-17(31)2/h4-8,13,16-17H,9-12,14-15H2,1-3H3,(H,26,32)/t16-,17-/m0/s1
  • InChiKey: JUSFANSTBFGBAF-IRXDYDNUSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL References
Homo sapiens FK506 binding protein 1A, 12kDa Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense peptidylprolyl isomerase-like protein, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum ko:K09571 FK506-binding protein 4/5, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FK506-binding protein 1A, putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania donovani fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Peptidylprolyl isomerase D (Cyclophilin D), related Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis immunophilin, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) FKBP5 protein Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K09568 FK506-binding protein 1, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania infantum fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative Get druggable targets OG5_126727 All targets in OG5_126727
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma congolense FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis fk506-binding protein, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 Get druggable targets OG5_126727 All targets in OG5_126727
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans hypothetical protein Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania donovani peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium berghei peptidyl-prolyl cis-trans isomerase FKBP35, putative Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium knowlesi peptidyl-prolyl cis-trans isomerase FKBP35, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis fk506 binding protein Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium yoelii FK506-binding protein Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania major fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative FK506 binding protein 1A, 12kDa 108 aa 107 aa 48.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0056 0.1372 0.1314
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0245 0.0209
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.2209 0.251
Brugia malayi myotactin form A 0.0063 0.1658 0.1864
Brugia malayi hypothetical protein 0.0063 0.1658 0.1864
Trypanosoma brucei protein kinase, putative 0.0027 0.0067 0.0377
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0065 0.1775 1
Brugia malayi Prion-like- 0.0031 0.0245 0.0209
Echinococcus multilocularis lachesin 0.0031 0.0245 0.018
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0075 0.2209 0.2156
Brugia malayi Peroxidasin 0.0031 0.0245 0.0209
Brugia malayi Immunoglobulin I-set domain containing protein 0.0094 0.3057 0.3504
Schistosoma mansoni nephrin 0.0229 0.9151 0.9682
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0063 0.1658 0.1602
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.1286 0.7137
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0031 0.0245 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.029 0.1303
Brugia malayi Immunoglobulin I-set domain containing protein 0.0094 0.3057 0.3504
Echinococcus granulosus neuroglian 0.0094 0.3057 0.301
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0245 0.0209
Schistosoma mansoni nephrin 0.0094 0.3057 0.3187
Brugia malayi Immunoglobulin I-set domain containing protein 0.02 0.7858 0.913
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0094 0.3057 0.3504
Echinococcus granulosus G1Y162 protein 0.0063 0.1658 0.1602
Schistosoma mansoni titin 0.0075 0.2209 0.2283
Loa Loa (eye worm) lethal protein 805 0.0063 0.1658 0.1864
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.2209 0.251
Onchocerca volvulus 0.0063 0.1658 0.7428
Brugia malayi protein unc-22 0.0075 0.2209 0.251
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.1775 1
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.2209 0.2283
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0063 0.1658 0.1864
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0065 0.1775 0.5
Loa Loa (eye worm) hypothetical protein 0.0094 0.3057 0.3504
Schistosoma mansoni cell adhesion molecule 0.0236 0.9449 1
Echinococcus multilocularis titin 0.0075 0.2209 0.2156
Brugia malayi Lethal protein 805 0.0063 0.1658 0.1864
Schistosoma mansoni factor for adipocyte differentiation 0.0063 0.1658 0.1696
Echinococcus granulosus titin 0.0075 0.2209 0.2156
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0031 0.0245 0.0833
Loa Loa (eye worm) hypothetical protein 0.0031 0.0245 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0661 0.3477
Schistosoma mansoni cell adhesion molecule 0.0031 0.0245 0.019
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0063 0.1658 0.1602
Schistosoma mansoni factor for adipocyte differentiation 0.0063 0.1658 0.1696
Schistosoma mansoni tyrosine kinase 0.0058 0.1466 0.1492
Loa Loa (eye worm) hypothetical protein 0.0173 0.6637 0.77
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.1286 0.13
Loa Loa (eye worm) hypothetical protein 0.0031 0.0245 0.0209
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.1286 0.1228
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.2209 0.251
Loa Loa (eye worm) hypothetical protein 0.0217 0.8601 1
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0065 0.1775 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0661 0.3477
Schistosoma mansoni cell adhesion molecule 0.0094 0.3057 0.3187
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0173 0.6637 0.6615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0162 0.0554
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) TK protein kinase 0.0039 0.0618 0.0645
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0063 0.1658 0.1602
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.2507 0.2859
Schistosoma mansoni ephrin receptor 0.009 0.2879 0.2997
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.1775 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0065 0.1775 0.172
Echinococcus granulosus twitchin 0.0167 0.6339 0.6315
Onchocerca volvulus 0.0063 0.1658 0.7428
Loa Loa (eye worm) hypothetical protein 0.0031 0.0245 0.0209
Schistosoma mansoni myosin-binding protein-related 0.0075 0.2209 0.2283
Trichomonas vaginalis immunophilin, putative 0.0065 0.1775 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0063 0.1658 0.1864
Schistosoma mansoni immunophilin 0.0065 0.1775 0.1821
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0065 0.1775 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0063 0.1658 0.1602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1286 0.7137
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.1286 0.1429
Schistosoma mansoni factor for adipocyte differentiation 0.0063 0.1658 0.1696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1286 0.7137
Echinococcus granulosus anosmin 1 0.0063 0.1658 0.1602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0787 0.4214
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0065 0.1775 1
Schistosoma mansoni titin 0.0031 0.0245 0.019
Onchocerca volvulus 0.0063 0.1658 0.7428
Echinococcus granulosus titin 0.0075 0.2209 0.2156
Echinococcus multilocularis Immunoglobulin 0.0154 0.5789 0.576
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0063 0.1658 0.1696
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0789 0.4226
Echinococcus granulosus Netrin receptor DCC 0.0063 0.1658 0.1602
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0063 0.1658 0.1864
Schistosoma mansoni cell adhesion molecule 0.0075 0.2209 0.2283
Echinococcus multilocularis neuroglian 0.0094 0.3057 0.301
Onchocerca volvulus 0.0063 0.1658 0.7428
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0929 0.5049
Echinococcus granulosus nephrin 0.0075 0.2209 0.2156
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0075 0.2209 0.251
Brugia malayi Fibronectin type III domain containing protein 0.0063 0.1658 0.1864
Brugia malayi Protein-tyrosine phosphatase 0.0063 0.1658 0.1864
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0063 0.1658 0.1602
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0065 0.1775 0.1821
Loa Loa (eye worm) FKBP5 protein 0.0065 0.1775 0.2002
Loa Loa (eye worm) hypothetical protein 0.0217 0.8601 1
Echinococcus granulosus neuroglian 0.0167 0.6339 0.6315
Echinococcus multilocularis transfer RNA-Phe 0.0075 0.2209 0.2156
Echinococcus granulosus defective proboscis extension response 0.0154 0.5789 0.576
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0065 0.1775 1
Echinococcus granulosus contactin 0.0094 0.3057 0.301
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0063 0.1658 0.1696
Schistosoma mansoni immunophilin 0.0065 0.1775 0.1821
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0063 0.1658 0.1696
Echinococcus multilocularis roundabout 2 0.0094 0.3057 0.301
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0245 0.0209
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0063 0.1658 0.1602
Giardia lamblia GTOR 0.0054 0.1286 0.7137
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0031 0.0245 0.019
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0063 0.1658 0.1602
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0094 0.3057 0.301
Schistosoma mansoni protein tyrosine phosphatase 0.0063 0.1658 0.1696
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0094 0.3057 0.3187
Schistosoma mansoni titin 0.0063 0.1658 0.1696
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0063 0.1658 0.1602
Echinococcus multilocularis roundabout 2 0.0248 1 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0075 0.2209 0.251
Leishmania major fk506-binding protein 1-like protein 0.0065 0.1775 1
Schistosoma mansoni hypothetical protein 0.0063 0.1658 0.1696
Echinococcus granulosus fibronectin type III domain-containing protein 0.0063 0.1658 0.1602
Echinococcus multilocularis Netrin receptor DCC 0.0063 0.1658 0.1602
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.1286 0.1429
Onchocerca volvulus 0.0063 0.1658 0.7428
Echinococcus multilocularis anosmin 1 0.0063 0.1658 0.1602
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0661 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1286 0.7137
Brugia malayi SPRY domain containing protein 0.0063 0.1658 0.1864
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0162 0.0554
Leishmania major peptidylprolyl isomerase-like protein 0.0065 0.1775 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0245 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0787 0.4214
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0065 0.1775 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0661 0.3477
Loa Loa (eye worm) hypothetical protein 0.0154 0.5789 0.6705
Brugia malayi myotactin form B 0.0063 0.1658 0.1864
Echinococcus multilocularis peroxidasin 0.0031 0.0245 0.018
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0063 0.1658 0.1696
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.1286 0.7245
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0027 0.0067 0.0377
Schistosoma mansoni tripartite motif protein trim9 0.0063 0.1658 0.1696
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0065 0.1775 0.172
Echinococcus multilocularis hemicentin 1 0.0031 0.0245 0.018
Echinococcus multilocularis titin 0.0063 0.1658 0.1602
Echinococcus granulosus EG95 0.0063 0.1658 0.1602
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0245 0.0209
Schistosoma mansoni vesicular amine transporter 0.0154 0.5789 0.6098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0164 0.0566
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0094 0.3057 0.3504
Loa Loa (eye worm) hypothetical protein 0.0217 0.8601 1
Brugia malayi Fibronectin type III domain containing protein 0.0063 0.1658 0.1864
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.2209 0.251
Loa Loa (eye worm) TK/ROR protein kinase 0.0039 0.0618 0.0645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.043 0.2126
Echinococcus granulosus usherin 0.0063 0.1658 0.1602
Loa Loa (eye worm) hypothetical protein 0.0075 0.2209 0.251
Brugia malayi Fibronectin type III domain containing protein 0.0217 0.8601 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0661 0.3477
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.1775 1
Onchocerca volvulus Tyrosine kinase homolog 0.0039 0.0618 0.2572
Echinococcus granulosus Fibronectin type III 0.0063 0.1658 0.1602
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0094 0.3057 0.301
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.1286 0.7137
Leishmania major hypothetical protein, conserved 0.0063 0.1658 0.9312
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Onchocerca volvulus 0.0063 0.1658 0.7428
Schistosoma mansoni roundabout 0.0031 0.0245 0.019
Loa Loa (eye worm) hypothetical protein 0.0186 0.7188 0.8345
Brugia malayi Lethal protein 805 0.0063 0.1658 0.1864
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.1286 0.7245
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0081 0.2507 0.2859
Schistosoma mansoni titin 0.0075 0.2209 0.2283
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0065 0.1775 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0067 0.0377
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) hypothetical protein 0.0031 0.0245 0.0209
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0154 0.5789 0.576
Trypanosoma brucei Pseudokinase, putative 0.0027 0.0067 0.0377
Echinococcus multilocularis cell adhesion molecule 0.0063 0.1658 0.1602
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0065 0.1775 1
Echinococcus multilocularis anosmin 1 0.0063 0.1658 0.1602
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) projectin 0.0075 0.2209 0.251
Onchocerca volvulus 0.0063 0.1658 0.7428
Loa Loa (eye worm) hypothetical protein 0.0154 0.5789 0.6705
Echinococcus granulosus roundabout 2 0.0094 0.3057 0.301
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.2209 0.251
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0065 0.1775 0.172
Echinococcus granulosus lachesin 0.0031 0.0245 0.018
Echinococcus multilocularis fk506 binding protein 0.0065 0.1775 0.172
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.1286 0.1228
Loa Loa (eye worm) CAMK protein kinase 0.0075 0.2209 0.251
Onchocerca volvulus 0.0075 0.2209 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0304 0.1388
Echinococcus granulosus insulin growth factor 1 receptor beta 0.009 0.2879 0.2831
Loa Loa (eye worm) hypothetical protein 0.0186 0.7188 0.8345
Echinococcus multilocularis roundabout 2 0.0094 0.3057 0.301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0304 0.1388
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0787 0.4214
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) hypothetical protein 0.0075 0.2209 0.251
Echinococcus granulosus anosmin 1 0.0063 0.1658 0.1602
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0065 0.1775 0.2002
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0661 0.3477
Echinococcus granulosus tyrosine protein kinase otk 0.0031 0.0245 0.018
Echinococcus granulosus roundabout 2 0.0094 0.3057 0.301
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0.1775 1
Echinococcus granulosus anosmin 1 0.0063 0.1658 0.1602
Onchocerca volvulus 0.0075 0.2209 1
Schistosoma mansoni septate junction protein 0.0031 0.0245 0.019
Schistosoma mansoni cell adhesion molecule 0.0094 0.3057 0.3187
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0075 0.2209 0.251
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.1286 0.7137
Loa Loa (eye worm) hypothetical protein 0.0031 0.0245 0.0209
Loa Loa (eye worm) hypothetical protein 0.0031 0.0245 0.0209
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.1286 0.7137
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.1286 0.7137
Echinococcus granulosus peroxidasin 0.0031 0.0245 0.018
Schistosoma mansoni hypothetical protein 0.0063 0.1658 0.1696
Loa Loa (eye worm) myotactin form A 0.0063 0.1658 0.1864
Echinococcus granulosus hemicentin 1 0.0031 0.0245 0.018
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0063 0.1658 0.1602
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0065 0.1775 0.5
Onchocerca volvulus 0.0063 0.1658 0.7428
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.1286 0.7137
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0039 0.0618 0.0554
Brugia malayi Fibronectin type III domain containing protein 0.0063 0.1658 0.1864
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0063 0.1658 0.1602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0787 0.4214
Onchocerca volvulus 0.0075 0.2209 1
Echinococcus multilocularis usherin 0.0063 0.1658 0.1602
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.1775 1
Trypanosoma brucei Flagellum attachment zone protein 20 0.0027 0.0067 0.0377
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0039 0.0618 0.0554
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0063 0.1658 0.9312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0164 0.0566
Brugia malayi Fibronectin type III domain containing protein 0.0063 0.1658 0.1864
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0789 0.4226
Onchocerca volvulus 0.0063 0.1658 0.7428
Echinococcus multilocularis neuroglian 0.0167 0.6339 0.6315
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0075 0.2209 0.251
Schistosoma mansoni cell adhesion molecule 0.0075 0.2209 0.2283
Onchocerca volvulus 0.0063 0.1658 0.7428
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0063 0.1658 0.9312
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.2209 0.251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0304 0.1388
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0789 0.4444
Loa Loa (eye worm) hypothetical protein 0.0154 0.5789 0.6705
Echinococcus multilocularis hemicentin 1 0.0031 0.0245 0.018
Echinococcus multilocularis Immunoglobulin 0.0154 0.5789 0.576
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0245 0.0209
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0094 0.3057 0.301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0164 0.0566
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0661 0.3477
Loa Loa (eye worm) UNCoordinated family member 0.0063 0.1658 0.1864
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0094 0.3057 0.301
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0063 0.1658 0.9338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0483 0.2434
Schistosoma mansoni neuroglian 0.0094 0.3057 0.3187
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.009 0.2879 0.2831
Onchocerca volvulus 0.0063 0.1658 0.7428
Brugia malayi Immunoglobulin I-set domain containing protein 0.0075 0.2209 0.251
Echinococcus multilocularis anosmin 1 0.0063 0.1658 0.1602
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Echinococcus multilocularis Netrin receptor DCC 0.0063 0.1658 0.1602
Echinococcus granulosus Netrin receptor DCC 0.0063 0.1658 0.1602
Schistosoma mansoni hemicentin 0.0075 0.2209 0.2283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.029 0.1303
Schistosoma mansoni immunophilin 0.0056 0.1372 0.1391
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0063 0.1658 0.1864
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.0618 0.0645
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0245 0.0209
Brugia malayi hypothetical protein 0.0217 0.8601 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.1372 0.153
Brugia malayi Immunoglobulin I-set domain containing protein 0.0217 0.8601 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0056 0.1372 0.1314
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Loa Loa (eye worm) TK/KIN16 protein kinase 0.02 0.7858 0.913
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.1658 0.9312
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0081 0.2507 0.2456
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0065 0.1775 0.2002
Echinococcus multilocularis tyrosine protein kinase otk 0.0031 0.0245 0.018
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0094 0.3057 0.301
Schistosoma mansoni hypothetical protein 0.0075 0.2209 0.2283
Echinococcus granulosus Immunoglobulin 0.0154 0.5789 0.576
Trichomonas vaginalis fk506-binding protein, putative 0.0065 0.1775 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0245 0.0209
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0065 0.1775 1
Brugia malayi Fibronectin type III domain containing protein 0.0063 0.1658 0.1864
Echinococcus multilocularis Fibronectin, type III 0.0063 0.1658 0.1602
Echinococcus granulosus Fibronectin type III domain containing protein 0.0063 0.1658 0.1602
Loa Loa (eye worm) hypothetical protein 0.0063 0.1658 0.1864
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0154 0.5789 0.6098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0787 0.4214
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0081 0.2507 0.2456
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0065 0.1775 0.2002
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0154 0.5789 0.6098
Loa Loa (eye worm) hypothetical protein 0.0031 0.0245 0.0209
Brugia malayi Immunoglobulin I-set domain containing protein 0.0094 0.3057 0.3504
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0162 0.0554
Schistosoma mansoni septate junction protein 0.0031 0.0245 0.019
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0063 0.1658 0.1864
Echinococcus granulosus cell adhesion molecule 0.0063 0.1658 0.1602
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0661 0.3477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0164 0.0566

Activities

Activity type Activity value Assay description Source Reference
CL (ADMET) = 10.4 ml/min.kg Clearance in CD1 mouse at 10 umol/kg, iv ChEMBL. 23375793
CLH (ADMET) < 4.2 uL/min Intrinsic clearance in human hepatocytes assessed per million cells ChEMBL. 25643210
CLH (ADMET) < 4.2 uL/min Clearance in human hepatocytes assessed per 10'6 cells ChEMBL. 23375793
IC50 (binding) = 20 nM BindingDB_Patents: Alternative Enzyme Assay. The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibit phosphorylation by recombinant mTOR.Test compounds were prepared as 10 mM stock solutions in DMSO and diluted into water as required to give a range of final assay concentrations. Aliquots (2 ul) of each compound dilution were placed into a well of a Greiner 384-well low volume (LV) white polystyrene plate (Greiner Bio-one). A 10 ul mixture of recombinant purified mTOR enzyme, 1 uM biotinylated peptide substrate (Biotin-Ahx-Lys-Lys-Ala-Asn-Gln-Val-Phe-Leu-Gly-Phe-Thr-Tyr-Val-Ala-Pro-Ser-Val-Leu-Glu-Ser-Val-Lys-Glu-NH2; Bachem UK Ltd), ATP (20 uM) in a buffer solution [comprising Tris-HCl pH7.4 buffer (50 mM), EGTA (0.1 mM), bovine serum albumin (0.5 mg/ml), DTT (1.25 mM) and manganese chloride (10 mM)] were added to the assay plates and incubated with compound for 2 hours at room temperature. ChEMBL. No reference
IC50 (binding) = 0.0028 uM Inhibition of recombinant FLAG-tagged mTOR (1362 to 2549) (unknown origin) expressed in HEK293 cells ChEMBL. 23375793
IC50 (binding) = 0.2 uM Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction of pS6 phosphorylation at Ser235/236 after 2 hrs ChEMBL. 23375793
IC50 (binding) = 47.5 uM Inhibition of human ERG ChEMBL. 23375793

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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