Detailed information for compound 1757854

Basic information

Technical information
  • TDR Targets ID: 1757854
  • Name: spiro[5.5]undecane-3,3-dicarboxylic acid
  • MW: 240.295 | Formula: C13H20O4
  • H donors: 2 H acceptors: 4 LogP: 3.51 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1(CCC2(CC1)CCCCC2)C(=O)O
  • InChi: 1S/C13H20O4/c14-10(15)13(11(16)17)8-6-12(7-9-13)4-2-1-3-5-12/h1-9H2,(H,14,15)(H,16,17)
  • InChiKey: KLTKZNIAIUVCON-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 18214-78-3
  • NSC211496

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GnHR receptor homolog 0.0047 0.0217 0.1489
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0217 0.0205
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0217 0.0205
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0217 0.0205
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0384 0.0838
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0982
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0063 0.0322 0.2148
Brugia malayi hypothetical protein 0.0073 0.0384 0.27
Loa Loa (eye worm) TYRA-2 protein 0.0047 0.0217 0.1489
Schistosoma mansoni hypothetical protein 0.0047 0.0216 0.0458
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0063 0.0322 0.2148
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Loa Loa (eye worm) hypothetical protein 0.0054 0.0262 0.1811
Echinococcus granulosus 7tm_1 domain containing protein 0.0047 0.0217 0.0462
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0262 0.0562
Brugia malayi ORL1-like opioid receptor 0.0047 0.0217 0.1489
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.0322 0.2249
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0562 0.3995
Entamoeba histolytica hypothetical protein 0.0073 0.0384 1
Onchocerca volvulus 0.01 0.0556 1
Brugia malayi PAN domain containing protein 0.01 0.0556 0.3953
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0063 0.0322 0.2148
Loa Loa (eye worm) CYP4Cod1 0.0063 0.0322 0.2249
Schistosoma mansoni opsin-like receptor 0.0047 0.0217 0.0462
Echinococcus multilocularis neuropeptide receptor A26 0.0047 0.0217 0.0205
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0311 0.0673
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0063 0.0322 0.2148
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0144 0.0802
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0063 0.0322 0.8443
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0217 0.0462
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0217 0.0462
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.067
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0063 0.0322 0.8443
Onchocerca volvulus 0.0047 0.0217 0.179
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0262 0.0562
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.0861 0.6166
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0217 0.0462
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0065 0.0331 1
Loa Loa (eye worm) PAN domain-containing protein 0.01 0.0556 0.3953
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0217 0.0205
Echinococcus multilocularis somatostatin receptor 0.0047 0.0217 0.0205
Onchocerca volvulus 0.0047 0.0217 0.179
Loa Loa (eye worm) PAN domain-containing protein 0.01 0.0556 0.3953
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0311 0.0673
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0262 0.0562
Mycobacterium ulcerans beta-lactamase 0.0035 0.0144 0.3571
Mycobacterium ulcerans lipase LipD 0.0035 0.0144 0.3571
Schistosoma mansoni hypothetical protein 0.0047 0.0216 0.0458
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0063 0.0322 0.8443
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0262 0.0562
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0063 0.0322 0.2148
Leishmania major cytochrome p450-like protein 0.0063 0.0322 0.8443
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0072 0.0379 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.0861 0.6166
Brugia malayi Trypsin family protein 0.0054 0.0262 0.1811
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0216 0.1476
Echinococcus multilocularis enteropeptidase 0.0054 0.0262 0.0249
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0047 0.0217 0.0462
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0295 0.0637
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0216 0.0458
Brugia malayi RNA binding protein 0.0062 0.0311 0.2169
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0047 0.0217 0.1489
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0217 0.1487
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0384 0.0372
Echinococcus granulosus DNA directed RNA polymerase I subunit RPA1 0.0026 0.0085 0.0164
Brugia malayi hypothetical protein 0.0047 0.0217 0.1489
Schistosoma mansoni microtubule-associated protein tau 0.0708 0.4444 1
Trypanosoma brucei DNA-directed rna polymerase I largest subunit, putative 0.0026 0.0085 0.225
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0379 1
Onchocerca volvulus 0.01 0.0556 1
Onchocerca volvulus 0.01 0.0556 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0144 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0217 0.0462
Schistosoma mansoni hypothetical protein 0.0054 0.0262 0.0562
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0063 0.0322 0.8443
Echinococcus granulosus glycoprotein Antigen 5 0.0054 0.0262 0.0562
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0063 0.0322 0.2148
Brugia malayi follicle stimulating hormone receptor 0.0047 0.0217 0.1489
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0054 0.0262 0.0249
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0047 0.0217 0.1489
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0047 0.0217 0.0462
Brugia malayi putative neuropeptide receptor NPR1 0.0047 0.0217 0.1489
Entamoeba histolytica hypothetical protein 0.0073 0.0384 1
Echinococcus multilocularis neuropeptide s receptor 0.0047 0.0217 0.0205
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Schistosoma mansoni neuropeptide f receptor 76f 0.0047 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Echinococcus granulosus GPCR family 2 0.0047 0.0216 0.0458
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0217 0.0462
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0217 0.0462
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0217 0.0462
Schistosoma mansoni hypothetical protein 0.0073 0.0384 0.0838
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0037 0.0178
Onchocerca volvulus 0.0047 0.0217 0.179
Echinococcus granulosus cytochrome P450 2K1 0.0063 0.0322 0.0698
Toxoplasma gondii microneme protein MIC17B 0.01 0.0556 0.0553
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0063 0.0322 0.8443
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0217 0.0462
Toxoplasma gondii microneme protein MIC17C 0.01 0.0556 0.0553
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0144 0.3571
Loa Loa (eye worm) hypothetical protein 0.01 0.0556 0.3953
Mycobacterium leprae Probable lipase LipE 0.0035 0.0144 0.4114
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0047 0.0217 0.0205
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0262 0.0249
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0216 0.1476
Brugia malayi neuropeptide F receptor 0.0047 0.0217 0.1489
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0144 0.3571
Loa Loa (eye worm) hypothetical protein 0.01 0.0556 0.3953
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0217 0.0462
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0047 0.0217 0.0462
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0982
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0047 0.0217 0.0462
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0047 0.0217 0.0462
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0047 0.0217 0.1489
Echinococcus granulosus G protein coupled receptor 139 0.0047 0.0217 0.0462
Echinococcus multilocularis geminin 0.0166 0.0979 0.0968
Schistosoma mansoni amine GPCR 0.0047 0.0217 0.0462
Echinococcus multilocularis allatostatin A receptor 0.0047 0.0217 0.0205
Echinococcus granulosus Mastin 0.0054 0.0262 0.0562
Onchocerca volvulus 0.0047 0.0217 0.179
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0047 0.0217 0.0205
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0217 0.0462
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0047 0.0217 0.0462
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0217 0.1489
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0311 0.2169
Brugia malayi hypothetical protein 0.0047 0.0217 0.1489
Schistosoma mansoni opsin-like receptor 0.0047 0.0217 0.0462
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1388 0.1377
Echinococcus multilocularis serotonin receptor 0.0047 0.0217 0.0205
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0217 0.0205
Echinococcus granulosus dro:myosuppressin receptor 0.0047 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.0035 0.0144 0.0951
Brugia malayi neuropeptide F receptor 0.0047 0.0217 0.1489
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0217 0.0462
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0047 0.0217 0.0462
Leishmania major DNA polymerase kappa, putative 0.0019 0.0037 0.067
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Echinococcus multilocularis neuropeptide FF receptor 2 0.0047 0.0217 0.0205
Onchocerca volvulus 0.0054 0.0262 0.2866
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0144 0.3571
Echinococcus granulosus 7TM GPCR rhodopsin 0.0047 0.0217 0.0462
Brugia malayi AKH receptor 0.0047 0.0217 0.1489
Echinococcus multilocularis dro:myosuppressin receptor 0.0047 0.0217 0.0205
Onchocerca volvulus 0.0047 0.0217 0.179
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0982
Onchocerca volvulus 0.0054 0.0262 0.2866
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0037 0.0055
Echinococcus multilocularis transmembrane protease serine 3 0.0054 0.0262 0.0249
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0217 0.0205
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0217 0.0205
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0037 0.0178
Loa Loa (eye worm) cytochrome P450 0.0063 0.0322 0.2249
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0063 0.0322 0.8443
Schistosoma mansoni hypothetical protein 0.0166 0.0979 0.2182
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0076 0.1718
Brugia malayi PAN domain containing protein 0.01 0.0556 0.3953
Echinococcus granulosus neuropeptide receptor 0.0047 0.0217 0.0462
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0063 0.0322 0.8443
Loa Loa (eye worm) melatonin receptor type 1A 0.0047 0.0217 0.1489
Toxoplasma gondii PAN domain-containing protein 0.01 0.0556 0.0553
Brugia malayi hypothetical protein 0.0047 0.0217 0.1489
Echinococcus granulosus serotonin receptor 0.0047 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Giardia lamblia DINP protein human, muc B family 0.0019 0.0037 0.2608
Echinococcus granulosus orexin receptor type 2 0.0047 0.0217 0.0462
Schistosoma mansoni biogenic amine receptor 0.0047 0.0217 0.0462
Echinococcus granulosus g protein coupled receptor 0.0047 0.0217 0.0462
Mycobacterium leprae Conserved hypothetical protein 0.0063 0.0322 0.9728
Brugia malayi hypothetical protein 0.023 0.1388 1
Trypanosoma brucei unspecified product 0.0019 0.0037 0.0982
Echinococcus granulosus sex peptide receptor 0.0047 0.0217 0.0462
Brugia malayi larval opioid receptor 0.0047 0.0217 0.1489
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0982
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0262 0.0562
Schistosoma mansoni hypothetical protein 0.0063 0.0322 0.0698
Echinococcus granulosus enteropeptidase 0.0054 0.0262 0.0562
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0144 0.4114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0217 0.0205
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0047 0.0217 0.0462
Onchocerca volvulus 0.0054 0.0262 0.2866
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta' 0.0015 0.0013 0.5
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0063 0.0322 0.8443
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0047 0.0217 0.0205
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Onchocerca volvulus 0.01 0.0556 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0144 0.0802
Leishmania major cytochrome p450-like protein 0.0063 0.0322 0.8443
Loa Loa (eye worm) RNA binding protein 0.0062 0.0311 0.2169
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0144 0.3571
Echinococcus granulosus microtubule associated protein 2 0.0708 0.4444 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0047 0.0217 0.0462
Echinococcus granulosus alpha 1A adrenergic receptor 0.0047 0.0217 0.0462
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0217 0.0462
Brugia malayi PAN domain containing protein 0.01 0.0556 0.3953
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0063 0.0322 0.8443
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0063 0.0322 0.8443
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0047 0.0217 0.0205
Echinococcus granulosus fmrfamide receptor 0.0047 0.0217 0.0462
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0217 0.0462
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.067
Brugia malayi putative neuropeptide receptor 0.0047 0.0217 0.1489
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0217 0.0205
Loa Loa (eye worm) hypothetical protein 0.0054 0.0262 0.1811
Brugia malayi hypothetical protein 0.0047 0.0217 0.1489
Schistosoma mansoni myosin xvIII 0.0047 0.0217 0.0462
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0217 0.0462
Leishmania major DNA-directed rna polymerase I largest subunit, putative 0.0026 0.0085 0.1981
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0144 0.3571
Brugia malayi beta-lactamase family protein 0.0035 0.0144 0.0951
Toxoplasma gondii cytochrome p450 superfamily protein 0.0063 0.0322 0.0315
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0295 0.0637
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0295 0.0637
Loa Loa (eye worm) hypothetical protein 0.01 0.0556 0.3953
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0262 0.0562
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0047 0.0217 0.1489
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0076 0.0064
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0144 0.0295
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Echinococcus granulosus peptide allatostatin:somatostatin 0.0047 0.0217 0.0462
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0063 0.0322 0.8443
Brugia malayi PAN domain containing protein 0.01 0.0556 0.3953
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.0861 0.6166
Mycobacterium tuberculosis Conserved protein 0.0035 0.0144 0.0802
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0217 0.0462
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0217 0.0205
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0047 0.0217 0.1489
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0037 0.067
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0217 0.1489
Brugia malayi G-protein coupled receptor 0.0047 0.0217 0.1489
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0063 0.0322 0.2148
Trypanosoma brucei RNA polymerase IIA largest subunit 0.0015 0.0013 0.0335
Toxoplasma gondii PAN domain-containing protein 0.1552 0.9845 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0054 0.0262 0.0562
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Brugia malayi Trypsin-like protease protein 5 0.0054 0.0262 0.1811
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0144 0.3786
Schistosoma mansoni growth hormone secretagogue receptor 0.0047 0.0217 0.0462
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0216 0.0203
Echinococcus granulosus geminin 0.0166 0.0979 0.2182
Schistosoma mansoni neuropeptide receptor 0.0047 0.0217 0.0462
Trypanosoma brucei cytochrome P450, putative 0.0063 0.0322 0.8495
Brugia malayi Trypsin family protein 0.0054 0.0262 0.1811
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0063 0.0322 0.2148
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0262 0.0562
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0144 0.0131
Onchocerca volvulus 0.0047 0.0217 0.179
Loa Loa (eye worm) hypothetical protein 0.0035 0.0144 0.0951
Loa Loa (eye worm) hypothetical protein 0.01 0.0556 0.3953
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0144 0.0802
Echinococcus multilocularis G protein coupled receptor 139 0.0047 0.0217 0.0205
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.067
Echinococcus multilocularis inositol monophosphatase 1 0.0072 0.0379 0.0367
Onchocerca volvulus 0.0047 0.0217 0.179
Trichomonas vaginalis esterase, putative 0.0035 0.0144 0.3571
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0047 0.0217 0.0205
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0217 0.0462
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0217 0.0462
Onchocerca volvulus 0.0054 0.0262 0.2866
Brugia malayi Trypsin family protein 0.0054 0.0262 0.1811
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0217 0.0205
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0144 0.3571
Mycobacterium tuberculosis Conserved protein 0.0035 0.0144 0.0802
Onchocerca volvulus 0.0047 0.0217 0.179
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0217 0.0205
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0262 0.0562
Echinococcus granulosus tachykinin peptides receptor 99D 0.0047 0.0217 0.0462
Brugia malayi TAR-binding protein 0.0062 0.0311 0.2169
Toxoplasma gondii subtilisin SUB12 0.01 0.0556 0.0553
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0216 0.1476
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0295 0.0287
Toxoplasma gondii microneme protein, putative 0.01 0.0556 0.0553
Mycobacterium ulcerans hypothetical protein 0.0054 0.0262 0.6799
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0217 0.0205
Loa Loa (eye worm) hypothetical protein 0.003 0.0107 0.0684
Onchocerca volvulus 0.01 0.0556 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0072 0.0379 1
Brugia malayi PAN domain containing protein 0.01 0.0556 0.3953
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0076 0.6693
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0063 0.0322 0.2148
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0217 0.0462
Echinococcus multilocularis GPCR, family 2 0.0047 0.0216 0.0203
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0262 0.0562
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0982
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Schistosoma mansoni biogenic amine receptor 0.0047 0.0217 0.0462
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0217 0.0462
Echinococcus granulosus dna polymerase eta 0.0019 0.0037 0.0055
Echinococcus multilocularis serotonin receptor 0.0047 0.0217 0.0205
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0217 0.1489
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0982
Schistosoma mansoni neuropeptide receptor 0.0047 0.0217 0.0462
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0037 0.0055
Brugia malayi Cytochrome P450 family protein 0.0063 0.0322 0.2249
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0144 0.0951
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0262 0.0562
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0217 0.0205
Treponema pallidum DNA-directed RNA polymerase subunit beta' 0.0015 0.0013 0.5
Schistosoma mansoni amine GPCR 0.0047 0.0217 0.0462
Entamoeba histolytica hypothetical protein 0.0073 0.0384 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0037 0.0661
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0063 0.0322 0.8443
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.067
Schistosoma mansoni survival motor neuron protein 0.0047 0.0217 0.0461
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0047 0.0217 0.0205
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0217 0.0205
Echinococcus granulosus g protein coupled receptor 0.0047 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0047 0.0217 0.0462
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0063 0.0322 0.2148
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0037 0.0025
Brugia malayi hypothetical protein 0.0047 0.0217 0.1489
Loa Loa (eye worm) hypothetical protein 0.0054 0.0262 0.1811
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.0217 0.0462
Brugia malayi PAN domain containing protein 0.01 0.0556 0.3953
Trypanosoma cruzi DNA-directed rna polymerase I largest subunit, putative 0.0026 0.0085 0.1981
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0144 0.0802
Onchocerca volvulus 0.01 0.0556 1
Brugia malayi Melatonin receptor type 1A 0.0047 0.0217 0.1489
Brugia malayi G-protein coupled receptor 0.0047 0.0217 0.1489
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0217 0.0205
Onchocerca volvulus 0.0047 0.0217 0.179
Leishmania major hypothetical protein, conserved 0.0035 0.0144 0.3571
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0072 0.0379 0.9867
Onchocerca volvulus 0.0047 0.0217 0.179
Brugia malayi Dopamine receptor protein 2 0.0047 0.0217 0.1489
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0037 0.067
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.0217 0.0462
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0982
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0217 0.0462
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0144 0.0951
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0217 0.0462
Trypanosoma cruzi cytochrome P450, putative 0.0063 0.0322 0.8443
Brugia malayi PAN domain containing protein 0.01 0.0556 0.3953
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1388 0.3103
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0063 0.0322 0.8443
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0295 0.7702
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0037 0.0178
Schistosoma mansoni amine GPCR 0.0047 0.0217 0.0462
Brugia malayi hypothetical protein 0.0016 0.002 0.005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0217 0.0205
Trypanosoma cruzi cytochrome P450, putative 0.0063 0.0322 0.8443
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0072 0.0379 0.0373
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0063 0.0322 0.2148
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Schistosoma mansoni hypothetical protein 0.0047 0.0217 0.0461
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0063 0.0322 0.2148
Loa Loa (eye worm) hypothetical protein 0.0054 0.0262 0.1811
Toxoplasma gondii PAN domain-containing protein 0.01 0.0556 0.0553
Toxoplasma gondii hypothetical protein 0.01 0.0556 0.0553
Brugia malayi PAN domain containing protein 0.01 0.0556 0.3953
Schistosoma mansoni hypothetical protein 0.0047 0.0216 0.0458
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0262 0.0562
Brugia malayi Trypsin family protein 0.0054 0.0262 0.1811
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Brugia malayi Cytochrome P450 family protein 0.0063 0.0322 0.2249
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0063 0.0322 0.8443
Mycobacterium tuberculosis Conserved protein 0.0035 0.0144 0.0802
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0047 0.0217 0.0205
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0037 0.0982
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0065 0.0331 0.2214
Echinococcus granulosus dna polymerase kappa 0.0019 0.0037 0.0055
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0054 0.0262 0.1811
Schistosoma mansoni hypothetical protein 0.0047 0.0217 0.0462
Echinococcus multilocularis DNA directed RNA polymerase I subunit RPA1 0.0026 0.0085 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0217 0.0205
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0295 0.1943
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Brugia malayi beta-lactamase family protein 0.0035 0.0144 0.0951
Toxoplasma gondii 1,3(4)-beta-glucanase 0.01 0.0556 0.0553
Trichomonas vaginalis inositol monophosphatase, putative 0.0072 0.0379 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Schistosoma mansoni DNA-directed RNA polymerase I 0.003 0.0107 0.0212
Loa Loa (eye worm) hypothetical protein 0.0047 0.0216 0.1476
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0178
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0217 0.0205
Echinococcus multilocularis Mastin 0.0054 0.0262 0.0249
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0982
Loa Loa (eye worm) hypothetical protein 0.0035 0.0144 0.0951
Loa Loa (eye worm) hypothetical protein 0.0101 0.0562 0.3995
Onchocerca volvulus 0.0047 0.0217 0.179
Echinococcus granulosus neuropeptide receptor A26 0.0047 0.0217 0.0462
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0311 0.2169
Echinococcus granulosus neuropeptide FF receptor 2 0.0047 0.0217 0.0462
Brugia malayi hypothetical protein 0.0047 0.0217 0.1489
Loa Loa (eye worm) beta-lactamase 0.0035 0.0144 0.0951
Echinococcus granulosus inositol monophosphatase 1 0.0072 0.0379 0.0827
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Schistosoma mansoni hypothetical protein 0.0166 0.0979 0.2182
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0063 0.0322 0.8443
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0217 0.0462
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0311 0.2169
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0047 0.0217 0.1489
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0063 0.0322 0.8443
Brugia malayi Serotonin receptor 0.0047 0.0217 0.1489
Leishmania major DNA polymerase eta, putative 0.0019 0.0037 0.067
Loa Loa (eye worm) hypothetical protein 0.0147 0.0861 0.6166
Loa Loa (eye worm) hypothetical protein 0.0054 0.0262 0.1811
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0072 0.0379 1
Echinococcus granulosus somatostatin receptor 0.0047 0.0217 0.0462
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0217 0.0462
Plasmodium vivax DNA-directed RNA polymerase I 190 kDa polypeptide, putative 0.003 0.0107 0.7191
Onchocerca volvulus 0.0047 0.0217 0.179
Brugia malayi hypothetical protein 0.0047 0.0217 0.1489
Onchocerca volvulus 0.0047 0.0217 0.179
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0262 0.0562
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0063 0.0322 0.2148
Onchocerca volvulus 0.0047 0.0217 0.179
Leishmania major cytochrome p450-like protein 0.0063 0.0322 0.8443
Mycobacterium leprae putative cytochrome p450 0.0063 0.0322 0.9728
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0311 0.0673
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Loa Loa (eye worm) hypothetical protein 0.0035 0.0144 0.0951
Onchocerca volvulus Neuropeptide F receptor homolog 0.0047 0.0217 0.179
Loa Loa (eye worm) hypothetical protein 0.023 0.1388 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0037 0.067
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0047 0.0217 0.0462
Entamoeba histolytica DNA-directed RNA polymerase I largest subunit, putative 0.003 0.0107 0.2533
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0063 0.0322 0.2148
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0217 0.0462
Onchocerca volvulus 0.01 0.0556 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0295 0.7702
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0076 0.1718
Schistosoma mansoni hypothetical protein 0.0054 0.0262 0.0562
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0262 0.0562
Loa Loa (eye worm) inositol-1 0.0072 0.0379 0.2664
Echinococcus granulosus g protein coupled receptor 0.0047 0.0217 0.0462
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0063 0.0322 0.8443
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Brugia malayi beta-lactamase 0.0035 0.0144 0.0951
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0982
Echinococcus multilocularis sex peptide receptor 0.0047 0.0217 0.0205
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0217 0.0205
Brugia malayi Cytochrome P450 family protein 0.0063 0.0322 0.2249
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0216 0.0458
Loa Loa (eye worm) trypsin family protein 0.0054 0.0262 0.1811
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0047 0.0217 0.0462
Schistosoma mansoni histamine h1 receptor 0.0047 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Echinococcus granulosus neuropeptide receptor 0.0047 0.0217 0.0462
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0311 0.0299
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0217 0.0205
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0262 0.0562
Schistosoma mansoni adenoreceptor 0.0047 0.0217 0.0462
Echinococcus multilocularis g-protein coupled receptor 0.0047 0.0217 0.0205
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0262 0.0562
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Giardia lamblia RNA polymerase AI large subunit 0.003 0.0107 1
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0217 0.0205
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0025
Brugia malayi G protein-coupled receptor F59B2.13 0.0047 0.0217 0.1489
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.0322 0.2249
Toxoplasma gondii PAN domain-containing protein 0.1552 0.9845 1
Brugia malayi Dopamine receptor protein 1 0.0047 0.0217 0.1489
Echinococcus granulosus tar DNA binding protein 0.0062 0.0311 0.0673
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0037 0.067
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0063 0.0322 0.8443
Schistosoma mansoni neuropeptide receptor 0.0047 0.0217 0.0462
Loa Loa (eye worm) PAN domain-containing protein 0.01 0.0556 0.3953
Loa Loa (eye worm) hypothetical protein 0.0025 0.0076 0.0458
Onchocerca volvulus 0.0047 0.0217 0.179
Echinococcus multilocularis microtubule associated protein 2 0.0708 0.4444 0.4437
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0047 0.0217 0.1489
Echinococcus granulosus allatostatin A receptor 0.0047 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Toxoplasma gondii PAN domain-containing protein 0.01 0.0556 0.0553
Schistosoma mansoni biogenic amine receptor 0.0047 0.0217 0.0462
Trichomonas vaginalis RNA polymerase A, putative 0.0026 0.0085 0.1981
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0047 0.0217 0.1489
Loa Loa (eye worm) PAN domain-containing protein 0.01 0.0556 0.3953
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0311 0.0673
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Schistosoma mansoni hypothetical protein 0.0047 0.0217 0.0462
Onchocerca volvulus 0.01 0.0556 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Schistosoma mansoni amine GPCR 0.0047 0.0217 0.0462
Echinococcus multilocularis glycoprotein Antigen 5 0.0054 0.0262 0.0249
Brugia malayi Inositol-1 0.0072 0.0379 0.2664
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0047 0.0217 0.1489
Toxoplasma gondii PAN domain-containing protein 0.01 0.0556 0.0553
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0384 0.0838
Loa Loa (eye worm) hypothetical protein 0.0035 0.0144 0.0951
Brugia malayi Cytochrome P450 family protein 0.0063 0.0322 0.2249
Schistosoma mansoni cytochrome P450 0.0063 0.0322 0.0698
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0063 0.0322 0.2148
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0063 0.0322 0.8443
Onchocerca volvulus 0.0047 0.0217 0.179
Toxoplasma gondii microneme protein MIC4 0.01 0.0556 0.0553
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0982
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0217 0.0462
Brugia malayi sulfakinin receptor protein 0.0047 0.0217 0.1489
Brugia malayi cytochrome P450 0.0063 0.0322 0.2249
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0217 0.0462
Schistosoma mansoni hypothetical protein 0.0101 0.0562 0.124
Trypanosoma brucei DNA-directed RNA polymerase III subunit C1 0.0015 0.0013 0.0335
Onchocerca volvulus 0.0047 0.0217 0.1785
Echinococcus granulosus transmembrane protease serine 3 0.0054 0.0262 0.0562
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0144 0.0295
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0144 0.3571
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0262 0.0562
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0217 0.1489
Brugia malayi hypothetical protein 0.0054 0.0262 0.1811
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0063 0.0322 0.8443
Schistosoma mansoni inositol monophosphatase 0.0072 0.0379 0.0827
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0379 1
Toxoplasma gondii PAN/Apple domain-containing protein 0.01 0.0556 0.0553
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0063 0.0322 0.2148
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0063 0.0322 0.8443
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0144 0.0295
Toxoplasma gondii microneme protein MIC17A 0.01 0.0556 0.0553
Schistosoma mansoni DNA polymerase eta 0.0019 0.0037 0.0055
Toxoplasma gondii DNA-directed RNA polymerase I RPA1 0.003 0.0107 0.0096
Brugia malayi PAN domain containing protein 0.01 0.0556 0.3953
Trypanosoma brucei DNA-directed RNA polymerase II subunit RPB1 0.0015 0.0013 0.0335
Brugia malayi RNA polymerase Rpb1, domain 2 family protein 0.003 0.0107 0.0684
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.0217 0.0462
Onchocerca volvulus 0.01 0.0556 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Toxoplasma gondii hypothetical protein 0.01 0.0556 0.0553
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0047 0.0217 0.179
Leishmania major hypothetical protein, conserved 0.0025 0.0076 0.1718
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0144 0.0802
Loa Loa (eye worm) hypothetical protein 0.0054 0.0262 0.1811
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0063 0.0322 0.2148
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0217 0.0205
Echinococcus multilocularis dna polymerase eta 0.0019 0.0037 0.0025
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0217 0.0462
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0063 0.0322 0.2148
Echinococcus granulosus hypothetical protein 0.0047 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0262 0.0562
Schistosoma mansoni opsin-like receptor 0.0047 0.0217 0.0462
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0217 0.0205
Onchocerca volvulus 0.01 0.0556 1
Schistosoma mansoni hypothetical protein 0.0047 0.0217 0.0462
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0076 0.1996
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Onchocerca volvulus 0.0054 0.0262 0.2866
Brugia malayi hypothetical protein 0.0047 0.0217 0.1489
Schistosoma mansoni neuropeptide receptor 0.0047 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Loa Loa (eye worm) hypothetical protein 0.0054 0.0262 0.1811
Echinococcus multilocularis G-protein coupled receptor, putative 0.0047 0.0217 0.0205
Brugia malayi hypothetical protein 0.0047 0.0217 0.1489
Brugia malayi Serotonin receptor 0.0047 0.0217 0.1489
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0063 0.0322 0.8443
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0063 0.0322 0.8443
Loa Loa (eye worm) PAN domain-containing protein 0.01 0.0556 0.3953
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0063 0.0322 0.8443
Schistosoma mansoni hypothetical protein 0.0047 0.0216 0.0458
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0037 0.067
Brugia malayi RE15519p 0.0047 0.0217 0.1489
Onchocerca volvulus 0.0054 0.0262 0.2866
Loa Loa (eye worm) hypothetical protein 0.01 0.0556 0.3953
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0144 0.3571
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0295 0.7702
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0054 0.0262 0.0562
Brugia malayi PAN domain containing protein 0.01 0.0556 0.3953
Loa Loa (eye worm) hypothetical protein 0.01 0.0556 0.3953
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0262 0.0562
Echinococcus granulosus neuropeptide s receptor 0.0047 0.0217 0.0462
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0982
Trypanosoma brucei DNA-directed RNA polymerase I largest subunit 0.0026 0.0085 0.225
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0217 0.0462
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1363 1
Schistosoma mansoni inositol monophosphatase 0.0072 0.0379 0.0827
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0144 0.0802
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0144 0.3571
Brugia malayi G protein-coupled receptor 0.0047 0.0217 0.1489
Onchocerca volvulus 0.01 0.0556 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0047 0.0217 0.1489
Entamoeba histolytica hypothetical protein 0.0073 0.0384 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0295 0.7702
Schistosoma mansoni amine GPCR 0.0047 0.0217 0.0462
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0063 0.0322 0.8495
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0047 0.0217 0.1489
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0311 0.0673
Brugia malayi Dopamine receptor 0.0047 0.0217 0.1489
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.01 0.0556 0.3953
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0295 0.0283
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0076 0.4812
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0072 0.0379 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0063 0.0322 0.8443
Onchocerca volvulus 0.0047 0.0217 0.179
Echinococcus multilocularis orexin receptor type 2 0.0047 0.0217 0.0205
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0037 0.067
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0379 1
Brugia malayi hypothetical protein 0.0025 0.0076 0.0458
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.0322 0.2249
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0054 0.0262 0.0562
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0063 0.0322 0.2148
Schistosoma mansoni hypothetical protein 0.0047 0.0217 0.0462
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0217 0.0462
Loa Loa (eye worm) hypothetical protein 0.0035 0.0144 0.0951
Toxoplasma gondii ABC1 family protein 0.0035 0.0144 0.0133
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0144 0.0802
Echinococcus multilocularis 0.0063 0.0322 0.031
Brugia malayi hypothetical protein 0.0047 0.0217 0.1489
Mycobacterium ulcerans hypothetical protein 0.0035 0.0144 0.3571
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0982
Plasmodium falciparum RNA polymerase I 0.003 0.0107 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0055
Loa Loa (eye worm) hypothetical protein 0.0047 0.0217 0.1489
Echinococcus granulosus g-protein coupled receptor 0.0047 0.0217 0.0462
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0063 0.0322 0.2148
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0217 0.0205
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0076 0.6693
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0047 0.0217 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0982
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0379 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0216 0.0203
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0217 0.0462

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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