TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 409.407 | Formula: C18H17F2N3O4S
H donors: 3 H acceptors: 4 LogP: 2.02 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC[C@]1(C)NC(=O)c2c(NC1=O)ccc(c2)S(=O)(=O)Nc1ccc(cc1F)F
InChi: 1S/C18H17F2N3O4S/c1-3-18(2)17(25)21-14-7-5-11(9-12(14)16(24)22-18)28(26,27)23-15-6-4-10(19)8-13(15)20/h4-9,23H,3H2,1-2H3,(H,21,25)(H,22,24)/t18-/m0/s1
InChiKey: APXWBCMMYGRMJI-SFHVURJKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	diacylglycerol O-acyltransferase 2	Starlite/ChEMBL	References
Mus musculus	mannoside acetylglucosaminyltransferase 2	Starlite/ChEMBL	References
Homo sapiens	diacylglycerol O-acyltransferase 1	Starlite/ChEMBL	References
Homo sapiens	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	Starlite/ChEMBL	References
Homo sapiens	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	Starlite/ChEMBL	References
Homo sapiens	monoacylglycerol O-acyltransferase 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	Get druggable targets OG5_133242	All targets in OG5_133242
Echinococcus granulosus	diacylglycerol O acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Trypanosoma brucei gambiense	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Brugia malayi	UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II	Get druggable targets OG5_133242	All targets in OG5_133242
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_130586	All targets in OG5_130586
Leishmania mexicana	hypothetical protein, conserved	Get druggable targets OG5_127120	All targets in OG5_127120
Neospora caninum	sterol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium yoelii	acyl transferase-related	Get druggable targets OG5_128200	All targets in OG5_128200
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_130586	All targets in OG5_130586
Schistosoma japonicum	2-acylglycerol O-acyltransferase 2-A, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133242	All targets in OG5_133242
Candida albicans	Acyl-CoA cholesterol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Neospora caninum	Diacylglycerol acyl transferase, related	Get druggable targets OG5_127120	All targets in OG5_127120
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	Get druggable targets OG5_133242	All targets in OG5_133242
Brugia malayi	diacylglycerol acyltransferase family protein	Get druggable targets OG5_127120	All targets in OG5_127120
Candida albicans	similar to diacylglycerol acyltransferase type 2B	Get druggable targets OG5_127120	All targets in OG5_127120
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128200	All targets in OG5_128200
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_130586	All targets in OG5_130586
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	Get druggable targets OG5_128200	All targets in OG5_128200
Brugia malayi	diacylglycerol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	ko:K00635 diacylglycerol O-acyltransferase [EC2.3.1.20], putative	Get druggable targets OG5_128200	All targets in OG5_128200
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Candida albicans	Acyl-CoA cholesterol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium falciparum	diacylglycerol O-acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Babesia bovis	diacylglycerol acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_130586	All targets in OG5_130586
Cryptosporidium parvum	diacylglycerol acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	Diacylglycerol O-acyltransferase 1, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_130586	All targets in OG5_130586
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_127120	All targets in OG5_127120
Leishmania major	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Neospora caninum	diacylglycerol acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	Diacylglycerol O-acyltransferase 1, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	2-acylglycerol O-acyltransferase 1, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Onchocerca volvulus		Get druggable targets OG5_127120	All targets in OG5_127120
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Candida albicans	similar to diacylglycerol acyltransferase type 2B	Get druggable targets OG5_127120	All targets in OG5_127120
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	Get druggable targets OG5_127120	All targets in OG5_127120
Schistosoma japonicum	ko:K00736 alpha-1,6-mannosyl-glycoprotein [EC2.4.1.143], putative	Get druggable targets OG5_133242	All targets in OG5_133242
Loa Loa (eye worm)	diacylglycerol acyltransferase	Get druggable targets OG5_127120	All targets in OG5_127120
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_130586	All targets in OG5_130586
Theileria parva	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium knowlesi	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Cryptosporidium parvum	hypothetical protein with 4 transmembrane domains	Get druggable targets OG5_127120	All targets in OG5_127120
Loa Loa (eye worm)	diacylglycerol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	Get druggable targets OG5_133242	All targets in OG5_133242
Trypanosoma congolense	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_130586	All targets in OG5_130586
Plasmodium berghei	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Trypanosoma brucei	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Toxoplasma gondii	dgat2l1-prov protein	Get druggable targets OG5_127120	All targets in OG5_127120
Cryptosporidium hominis	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	Get druggable targets OG5_128200	All targets in OG5_128200
Leishmania braziliensis	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_130586	All targets in OG5_130586
Leishmania donovani	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_130586	All targets in OG5_130586
Leishmania infantum	diacylglycerol acyltransferase, putative	Get druggable targets OG5_127120	All targets in OG5_127120

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania major	diacylglycerol acyltransferase, putative	monoacylglycerol O-acyltransferase 2	334 aa	297 aa	26.6 %
Leishmania major	diacylglycerol acyltransferase, putative	diacylglycerol O-acyltransferase 2	345 aa	326 aa	26.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	sterol O-acyltransferase 1	0.0026	0.0127	0.0126
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0151	0.046
Leishmania major	cathepsin L-like protease	0.0022	0.0081	0.0362
Schistosoma mansoni	phd/f-box containing protein	0.0016	0.0009	0.0009
Brugia malayi	beta-lactamase family protein	0.0042	0.0319	0.0319
Brugia malayi	MBOAT family protein	0.0026	0.0127	0.0126
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.0127	0.0576
Echinococcus multilocularis	zinc finger protein	0.0021	0.0075	0.0074
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0148	0.1557	0.1557
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0148	0.1557	0.1557
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0321	0.0978
Loa Loa (eye worm)	LGC-31 protein	0.0148	0.1557	0.1557
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0081	0.0362
Giardia lamblia	Fructose-bisphosphate aldolase	0.0294	0.328	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0319	0.0973
Echinococcus granulosus	glycine receptor subunit beta	0.0148	0.1557	0.1557
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0294	0.328	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0811	0.0811
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0196	0.2122	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0081	0.0362
Loa Loa (eye worm)	fibroinase	0.0022	0.0081	0.0081
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0081	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.0127	0.0126
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0148	0.1557	0.1557
Echinococcus granulosus	cpg binding protein	0.0032	0.0205	0.0205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0081	0.0248
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0148	0.1557	0.1557
Brugia malayi	Cation transporter family protein	0.0581	0.6646	0.6646
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0081	0.0248
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0064	0.057	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0866	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0022	0.0081	0.0081
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0184	0.0184
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0081	0.0081
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0064	0.057	0.0569
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0064	0.057	0.0569
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0144	0.1512	0.447
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.011	0.0109
Echinococcus multilocularis	cathepsin L cysteine protease	0.0022	0.0081	0.0081
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0148	0.1557	0.1557
Onchocerca volvulus		0.0084	0.0811	0.1112
Brugia malayi	MBOAT family protein	0.0026	0.0127	0.0126
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0064	0.057	0.0569
Toxoplasma gondii	hypothetical protein	0.0052	0.0435	0.2015
Onchocerca volvulus		0.0239	0.2632	0.3886
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0153	0.1626	0.765
Onchocerca volvulus		0.0026	0.0127	0.0069
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0081	0.0081
Echinococcus multilocularis	cysteine protease	0.0022	0.0081	0.0081
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0148	0.1557	0.1557
Treponema pallidum	fructose-bisphosphate aldolase	0.0294	0.328	1
Trichomonas vaginalis	esterase, putative	0.0042	0.0319	0.0973
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0321	0.0364
Echinococcus multilocularis	lysine specific demethylase 6a	0.0016	0.0009	0.0009
Trichomonas vaginalis	conserved hypothetical protein	0.0133	0.139	0.4238
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0026	0.0127	0.0126
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0019	0.0051	0.0051
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0036	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0064	0.057	0.0569
Schistosoma mansoni	zinc finger protein	0.0021	0.0075	0.0074
Brugia malayi	jmjC domain containing protein	0.0016	0.0009	0.0009
Echinococcus multilocularis	dnaJ subfamily B	0.0412	0.4661	0.466
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0148	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0286	0.0285
Brugia malayi	beta-lactamase family protein	0.0042	0.0319	0.0319
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0148	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0009	0.0009
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0386	0.0385
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0148	0.1557	0.1557
Schistosoma mansoni	nAChR subunit	0.0148	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0811	0.0811
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0084	0.0811	0.0811
Schistosoma mansoni	chromobox protein	0.007	0.0648	0.0647
Echinococcus granulosus	chromobox protein 1	0.007	0.0648	0.0647
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0319	0.0319
Brugia malayi	hypothetical protein	0.0064	0.057	0.0569
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0064	0.057	0.0569
Onchocerca volvulus		0.0148	0.1557	0.2248
Brugia malayi	Bromodomain containing protein	0.0039	0.0277	0.0276
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0026	0.0127	0.0126
Schistosoma mansoni	neurotransmitter gated ion channel	0.0064	0.057	0.0569
Echinococcus granulosus	geminin	0.0171	0.1828	0.1827
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Trichomonas vaginalis	conserved hypothetical protein	0.0133	0.139	0.4238
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0084	0.0811	0.0811
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0081	0.0248
Brugia malayi	jmjC domain containing protein	0.0059	0.0519	0.0519
Onchocerca volvulus	Putative nachr subunit	0.0148	0.1557	0.2248
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0042	0.0319	0.0318
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.0127	0.0126
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0148	0.1557	0.1557
Leishmania major	diacylglycerol acyltransferase, putative	0.0043	0.0333	0.155
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0581	0.6646	0.6646
Schistosoma mansoni	cpg binding protein	0.0029	0.0163	0.0163
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0294	0.328	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0148	0.1557	0.1557
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0319	0.1485
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0319	0.0319
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0026	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0811	0.0811
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0016	0.0009	0.0021
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0084	0.0811	0.0811
Brugia malayi	MBOAT family protein	0.0026	0.0127	0.0126
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0026	0.0025
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0026	0.0127	0.0126
Loa Loa (eye worm)	hhat protein	0.0026	0.0127	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0811	0.0811
Echinococcus granulosus	phd:f box containing protein	0.0016	0.0009	0.0009
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0081	0.0362
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0144	0.1512	1
Schistosoma mansoni	nAChR subunit	0.0148	0.1557	0.1557
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0148	0.1557	0.1557
Schistosoma mansoni	zinc finger protein	0.0015	0.0005	0.0004
Brugia malayi	jmjC domain containing protein	0.0016	0.0009	0.0009
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0148	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0517	0.59	0.59
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0036	0.0109
Trypanosoma cruzi	GUP1, putative	0.0026	0.0127	0.0576
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0081	0.0362
Onchocerca volvulus		0.0064	0.057	0.0744
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0127	0.0386
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0016	0.0009	0.0021
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0022	0.0081	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0581	0.6646	0.6646
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0081	0.0362
Schistosoma mansoni	nAChR subunit	0.0148	0.1557	0.1557
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.0508	0.2361
Loa Loa (eye worm)	hypothetical protein	0.0581	0.6646	0.6646
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0064	0.057	0.0569
Schistosoma mansoni	hypothetical protein	0.0043	0.0333	0.0332
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0009	0.0009
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0294	0.328	1
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0321	0.0978
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0036	0.0109
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0081	0.0248
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0148	0.1557	0.1557
Brugia malayi	hypothetical protein	0.0064	0.057	0.0569
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0043	0.0333	0.155
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0557	0.0557
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0081	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0064	0.057	0.0569
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0542	0.0541
Toxoplasma gondii	diacylglycerol acyltransferase	0.0043	0.0333	0.1532
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0148	0.1557	0.1557
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0294	0.328	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0081	0.0248
Trichomonas vaginalis	conserved hypothetical protein	0.0133	0.139	0.4238
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0127	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0064	0.057	0.0569
Brugia malayi	MBOAT family protein	0.0026	0.0127	0.0126
Toxoplasma gondii	ABC1 family protein	0.0042	0.0319	0.1466
Echinococcus granulosus	sterol O acyltransferase 1	0.0026	0.0127	0.0126
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	0.0866	1	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Toxoplasma gondii	cathepsin CPL	0.0022	0.0081	0.0342
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.0127	0.0141
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0648	0.1975
Leishmania major	hypothetical protein, conserved	0.0026	0.0127	0.0576
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0153	0.1626	0.1625
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0148	0.1557	0.1557
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0319	0.0319
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0063	0.0561	0.0561
Toxoplasma gondii	dgat2l1-prov protein	0.0196	0.2122	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0064	0.057	0.0569
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0022	0.0081	0.0081
Echinococcus multilocularis	chromobox protein 1	0.007	0.0648	0.0647
Onchocerca volvulus		0.0042	0.0319	0.0362
Brugia malayi	diacylglycerol acyltransferase family protein	0.0196	0.2122	0.2122
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0148	0.1557	0.1557
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.0127	0.0126
Brugia malayi	Cation transporter family protein	0.0148	0.1557	0.1557
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0184	0.0184
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0022	0.0081	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0148	0.1557	0.1557
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0294	0.328	1
Onchocerca volvulus		0.0581	0.6646	1
Loa Loa (eye worm)	ACC-1 protein	0.0148	0.1557	0.1557
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0084	0.0811	0.0811
Onchocerca volvulus		0.0196	0.2122	0.3109
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0148	0.1557	0.1557
Trichomonas vaginalis	conserved hypothetical protein	0.0133	0.139	0.4238
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0319	0.0319
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0148	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0064	0.057	0.0569
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0542	0.252
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0811	0.0811
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0062	0.0549	0.0549
Leishmania major	glycerol uptake protein, putative	0.0026	0.0127	0.0576
Leishmania major	cathepsin L-like protease	0.0022	0.0081	0.0362
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0148	0.1557	0.1557
Schistosoma mansoni	jumonji domain containing protein	0.0016	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0071	0.066	0.066
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0148	0.1557	0.1557
Echinococcus multilocularis	glycine receptor subunit beta	0.0148	0.1557	0.1557
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0164	0.0163
Echinococcus multilocularis	sterol O acyltransferase 1	0.0026	0.0127	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0319	0.0319
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0286	0.0871
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0385
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0022	0.0081	0.0446
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0294	0.328	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0148	0.1557	0.1557
Schistosoma mansoni	hypothetical protein	0.0171	0.1828	0.1827
Echinococcus multilocularis	lysine specific demethylase 5A	0.0059	0.0519	0.0519
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0026	0.0025
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0081	0.0248
Echinococcus granulosus	dnaJ subfamily B	0.0412	0.4661	0.466
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.011	0.0109
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0064	0.057	0.0569
Schistosoma mansoni	zinc finger protein	0.0026	0.0127	0.0126
Loa Loa (eye worm)	heterochromatin protein 1	0.007	0.0648	0.0647
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0064	0.057	0.0569
Schistosoma mansoni	hypothetical protein	0.0412	0.4661	0.466
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0081	0.0248
Echinococcus granulosus	jumonji domain containing 1A	0.0016	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0319	0.0319
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0333	0.0117
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0059	0.0519	0.0519
Leishmania major	glycerol uptake protein, putative	0.0026	0.0127	0.0576
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0153	0.1626	1
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	0.0866	1	1
Schistosoma mansoni	nAChR subunit	0.0148	0.1557	0.1557
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0081	0.0248
Plasmodium vivax	vivapain-2	0.0022	0.0081	0.0446
Trypanosoma cruzi	GUP1, putative	0.0026	0.0127	0.0576
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.0127	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.0127	0.0141
Echinococcus multilocularis	JmjC domain containing protein 4	0.0016	0.0009	0.0009
Echinococcus multilocularis	nAChR subunit	0.0148	0.1557	0.1557
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0148	0.1557	0.1557
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0148	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0022	0.0081	0.0248
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.021	0.2292	0.2292
Schistosoma mansoni	hypothetical protein	0.0171	0.1828	0.1827
Echinococcus multilocularis	cpg binding protein	0.0032	0.0205	0.0205
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0064	0.057	0.0569
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0081	0.0248
Trypanosoma brucei	glycerol uptake protein, putative	0.0026	0.0127	0.0576
Brugia malayi	MBOAT family protein	0.0026	0.0127	0.0126
Onchocerca volvulus		0.0042	0.0319	0.0362
Toxoplasma gondii	mono- or diacylglycerol acyltransferase	0.0043	0.0333	0.1532
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0127	0.0126
Toxoplasma gondii	hypothetical protein	0.0026	0.0127	0.0556
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0009	0.0009
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0026	0.0025
Leishmania major	hypothetical protein, conserved	0.0016	0.0009	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0064	0.057	0.0569
Brugia malayi	jmjC domain containing protein	0.0016	0.0009	0.0009
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0319	0.0973
Brugia malayi	hypothetical protein	0.0064	0.057	0.0569
Brugia malayi	Heterochromatin protein 1	0.007	0.0648	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0811	0.0811
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0151	0.046
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0059	0.0519	0.0519
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0026	0.0127	0.0126
Leishmania major	hypothetical protein, conserved	0.0042	0.0319	0.1485
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0127	0.0126
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0196	0.2122	0.2122
Brugia malayi	beta-lactamase	0.0042	0.0319	0.0319
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0542	0.1867
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0294	0.328	1
Schistosoma mansoni	phosphatidylserine receptor	0.0016	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0064	0.057	0.0569
Brugia malayi	excitatory GABA receptor EXP-1A	0.0148	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0064	0.057	0.0569
Leishmania major	cathepsin L-like protease	0.0022	0.0081	0.0362
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0148	0.1557	0.1557
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0081	0.0248
Trichomonas vaginalis	conserved hypothetical protein	0.0133	0.139	0.4238
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0043	0.0333	0.155
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0009	0.0009
Schistosoma mansoni	hypothetical protein	0.0026	0.0127	0.0126
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0022	0.0081	0.0081
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.0127	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0186	0.0185
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0148	0.1557	0.1557
Onchocerca volvulus		0.0581	0.6646	1
Brugia malayi	Hhat protein	0.0026	0.0127	0.0126
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0319	0.0973
Onchocerca volvulus		0.0064	0.057	0.0744
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.0127	0.0126
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0036	0.0109
Trypanosoma cruzi	cruzipain precursor, putative	0.0022	0.0081	0.0362
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.0127	0.0126
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0148	0.1557	0.1557
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0064	0.057	0.0569
Leishmania major	hypothetical protein, unknown function,protein, unknown function	0.0043	0.0333	0.155
Echinococcus granulosus	histone lysine methyltransferase setb	0.0048	0.0386	0.0385
Trichomonas vaginalis	conserved hypothetical protein	0.0133	0.139	0.4238
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0081	0.0362
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0319	0.0319
Leishmania major	cathepsin L-like protease	0.0022	0.0081	0.0362
Echinococcus multilocularis	geminin	0.0171	0.1828	0.1827
Echinococcus multilocularis	jumonji domain containing 1A	0.0016	0.0009	0.0009
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0144	0.1512	1
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0043	0.0333	0.155
Trichomonas vaginalis	conserved hypothetical protein	0.0133	0.139	0.4238
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0153	0.1626	0.1625
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0081	0.0248
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0026	0.0127	0.0126
Leishmania major	diacylglycerol acyltransferase, putative	0.0043	0.0333	0.155
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0542	0.2536
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0294	0.328	1
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0148	0.1557	0.1557
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0081	0.0362
Brugia malayi	Cation transporter family protein	0.0148	0.1557	0.1557
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0081	0.0362
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0148	0.1557	0.1557
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0542	0.0541
Entamoeba histolytica	hypothetical protein	0.0084	0.0811	0.2281
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0081	0.0081
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0386	0.0385
Echinococcus multilocularis	cysteine protease	0.0022	0.0081	0.0081
Loa Loa (eye worm)	cysteine protease	0.0022	0.0081	0.0081
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0249	0.0248
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0542	0.1867
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0064	0.057	0.0569
Onchocerca volvulus		0.0084	0.0811	0.1112
Leishmania major	cathepsin L-like protease	0.0022	0.0081	0.0362
Echinococcus granulosus	chromobox protein 1	0.007	0.0648	0.0647
Echinococcus multilocularis	cathepsin L cysteine protease	0.0022	0.0081	0.0081
Brugia malayi	PHD-finger family protein	0.0027	0.0138	0.0137
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0081	0.0362
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0542	0.0835
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.0127	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0081	0.0081
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0036	0.0109
Leishmania major	glycerol uptake protein, putative	0.0026	0.0127	0.0576
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0319	0.0973
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0127	0.0386
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.0127	0.0126
Schistosoma mansoni	nAChR subunit	0.0148	0.1557	0.1557
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0081	0.0081
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.0319	0.1485
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0319	0.0319
Echinococcus granulosus	lysine specific demethylase 5A	0.0063	0.0561	0.0561
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0319	0.0319
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0542	0.1867
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0278	0.0277
Leishmania major	cathepsin L-like protease	0.0022	0.0081	0.0362
Brugia malayi	diacylglycerol acyltransferase	0.0153	0.1626	0.1625
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0148	0.1557	0.1557
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0043	0.0333	0.155
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0081	0.0248
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0148	0.1557	0.1557
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0127	0.0386
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0153	0.1626	1
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0196	0.2122	0.2122
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0148	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0196	0.2122	1
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0148	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0064	0.057	0.0569
Schistosoma mansoni	acetylcholine receptor-related	0.0064	0.057	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.0127	0.0141
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0148	0.1557	0.1557
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0081	0.0248
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0184	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0811	0.0811
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0081	0.0362
Onchocerca volvulus		0.0042	0.0319	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1323	0.1322
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0269	0.2988	1
Entamoeba histolytica	hypothetical protein, conserved	0.0026	0.0127	0.0141
Entamoeba histolytica	vacuolar protein sorting 26	0.0026	0.0127	0.0141
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0026	0.0127	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0306	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0127	0.0126
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0022	0.0081	0.0248
Echinococcus granulosus	glycine receptor subunit beta	0.0148	0.1557	0.1557
Schistosoma mansoni	cpg binding protein	0.0032	0.0205	0.0205
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0064	0.057	0.0569
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0081	0.0362
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0062	0.0549	0.0549
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0319	0.1917
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0081	0.0248
Trichomonas vaginalis	set domain proteins, putative	0.0239	0.2632	0.8025
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0081	0.0362
Schistosoma mansoni	neurotransmitter gated ion channel	0.0084	0.0811	0.0811
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0084	0.0811	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0064	0.057	0.0569
Plasmodium vivax	SET domain protein, putative	0.0031	0.0184	0.1082
Brugia malayi	Bromodomain containing protein	0.0077	0.073	0.0729
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0163	0.0163
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.0127	0.0126
Onchocerca volvulus		0.0148	0.1557	0.2248
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0348	0.0347
Trypanosoma brucei	diacylglycerol acyltransferase, putative	0.0196	0.2122	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0148	0.1557	0.1557
Echinococcus multilocularis	phd:f box containing protein	0.0016	0.0009	0.0009
Onchocerca volvulus		0.0029	0.0163	0.0125
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0081	0.0362
Schistosoma mansoni	diacylglycerol O-acyltransferase	0.0043	0.0333	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0319	0.0319
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0068	0.0067
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0033	0.0032
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0081	0.0081
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.0127	0.0126
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0286	0.0871
Loa Loa (eye worm)	hypothetical protein	0.0064	0.057	0.0569
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0148	0.1557	0.1557
Onchocerca volvulus		0.0042	0.0319	0.0362
Onchocerca volvulus		0.0148	0.1557	0.2248
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0048	0.0386	0.0385
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0036	0.0109
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.0561	0.0561
Schistosoma mansoni	jumonji domain containing protein	0.0059	0.0519	0.0519
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0148	0.1557	0.1557
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0064	0.057	0.0569
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0153	0.1626	0.765
Brugia malayi	hypothetical protein	0.0064	0.057	0.0569
Loa Loa (eye worm)	GABA receptor subunit	0.0084	0.0811	0.0811
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0148	0.1557	0.1557
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0009	0.0009
Loa Loa (eye worm)	acetylcholine receptor protein	0.0064	0.057	0.0569
Entamoeba histolytica	hypothetical protein	0.0026	0.0127	0.0141
Echinococcus multilocularis	glycine receptor subunit beta	0.0148	0.1557	0.1557
Trichomonas vaginalis	porcupine, putative	0.0026	0.0127	0.0386
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0064	0.057	0.0569
Schistosoma mansoni	chromobox protein	0.007	0.0648	0.0647
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0648	0.1975
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0249	0.0248
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0081	0.0248
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0036	0.0109
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0294	0.328	1
Leishmania major	glycerol uptake protein, putative	0.0026	0.0127	0.0576
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.0127	0.0576
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0026	0.0127	0.0126
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0148	0.1557	0.1557
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0779	0.2375
Echinococcus granulosus	zinc finger protein	0.0021	0.0075	0.0074
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0022	0.0081	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0064	0.057	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0009	0.0009
Trypanosoma brucei	glycerol uptake protein, putative	0.0026	0.0127	0.0576
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0026	0.0127	0.0126
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0081	0.0248
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0148	0.1557	0.1557
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0148	0.1557	0.1557
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0542	0.0541
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0542	0.0541
Brugia malayi	hypothetical protein	0.0064	0.057	0.0569
Onchocerca volvulus		0.0031	0.0186	0.0159
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0063	0.0561	0.0561
Schistosoma mansoni	nAChR subunit	0.0148	0.1557	0.1557
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0026	0.0127	0.0126
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0084	0.0811	0.0811
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0294	0.328	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0022	0.0081	0.0081
Echinococcus multilocularis	chromobox protein 1	0.007	0.0648	0.0647
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0081	0.0248
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0016	0.0009	0.0009
Brugia malayi	jmjC domain containing protein	0.0016	0.0009	0.0009
Echinococcus granulosus	nAChR subunit	0.0084	0.0811	0.0811
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0026	0.0127	0.0126
Leishmania major	cathepsin L-like protease	0.0022	0.0081	0.0362
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0022	0.0081	0.0081
Plasmodium vivax	vivapain-2	0.0022	0.0081	0.0446
Brugia malayi	jmjC domain containing protein	0.0063	0.0561	0.0561
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0081	0.0362
Schistosoma mansoni	protein phosphatase 2C	0.0016	0.0009	0.0009
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0148	0.1557	0.1557
Loa Loa (eye worm)	ctsf protein	0.0022	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0811	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Leishmania major	glycerol uptake protein, putative	0.0026	0.0127	0.0576
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0153	0.1626	0.1625
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0148	0.1557	0.1557
Schistosoma mansoni	nAChR subunit	0.0064	0.057	0.0569
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0148	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0319	0.0319
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0081	0.0081
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0148	0.1557	0.1557
Schistosoma mansoni	neurotransmitter gated ion channel	0.0064	0.057	0.0569
Schistosoma mansoni	nAChR subunit	0.0148	0.1557	0.1557
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0016	0.0009	0.0021
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.011	0.0109
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0026	0.0127	0.0126
Onchocerca volvulus		0.0581	0.6646	1
Schistosoma mansoni	hypothetical protein	0.0015	0.0005	0.0004
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0286	0.0311
Echinococcus multilocularis	nAChR subunit	0.0084	0.0811	0.0811
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0319	0.0319
Echinococcus granulosus	lysine specific demethylase 6a	0.0016	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Schistosoma mansoni	hypothetical protein	0.0021	0.0068	0.0067
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0319	0.0973
Schistosoma mansoni	bromodomain containing protein	0.0065	0.0592	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0064	0.057	0.0569
Loa Loa (eye worm)	ACC-1 protein	0.0148	0.1557	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0064	0.057	0.0569
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0081	0.0248
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.0127	0.0126
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0081	0.0248
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0081	0.0248
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.0127	0.0126
Leishmania major	cysteine peptidase A (CPA)	0.0022	0.0081	0.0362
Brugia malayi	Pre-SET motif family protein	0.0031	0.0184	0.0184
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0036	0.0109
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0022	0.0081	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0133	0.139	0.4238
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0581	0.6646	0.6646
Schistosoma mansoni	cpg binding protein	0.0032	0.0205	0.0205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0081	0.0248
Echinococcus granulosus	nAChR subunit	0.0148	0.1557	0.1557
Schistosoma mansoni	nAChR subunit	0.0064	0.057	0.0569
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0319	0.1485
Schistosoma mansoni	diacylglycerol O-acyltransferase	0.0043	0.0333	0.0332
Leishmania major	diacylglycerol acyltransferase, putative	0.0196	0.2122	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0319	0.0319
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0153	0.1626	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Trypanosoma brucei	diacylglycerol acyltransferase, putative	0.0043	0.0333	0.155
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	0.0866	1	1
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0064	0.057	0.0569
Brugia malayi	Pre-SET motif family protein	0.021	0.2292	0.2292
Echinococcus granulosus	cathepsin l1	0.0022	0.0081	0.0081
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0019	0.0051	0.0051
Leishmania major	cathepsin L-like protease	0.0022	0.0081	0.0362
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0022	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1557	0.1557
Echinococcus granulosus	JmjC domain containing protein 4	0.0016	0.0009	0.0009
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0026	0.0127	0.0386
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0148	0.1557	0.1557
Onchocerca volvulus		0.0064	0.057	0.0744
Loa Loa (eye worm)	hhat protein	0.0026	0.0127	0.0126
Brugia malayi	chromobox protein homolog 3	0.0039	0.0286	0.0285

Activities

Activity type	Activity value	Assay description	Source	Reference
Drug metabolism (ADMET)	= 80 %	Drug metabolism assessed as recombinant CYP3A4 (unknown origin)-mediated metabolite formation at 1 uM after 30 mins by LCMS analysis	ChEMBL.	23541669
IC50 (binding)	> 4	Inhibition of human recombinant AWAT2 expressed in insect cell membrane using cetyl alcohol and [14C]oleoyl coenzyme A as substrate after 10 to 15 mins by liquid scintillation counting	ChEMBL.	23541669
IC50 (binding)	> 4	Inhibition of human recombinant AWAT1 expressed in insect cell membrane using palmitoleyl alcohol and [14C]stearoyl coenzyme A as substrate after 10 to 15 mins by liquid scintillation counting	ChEMBL.	23541669
IC50 (binding)	> 5	Inhibition of human recombinant DGAT2 using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counting	ChEMBL.	23541669
IC50 (binding)	> 5	Inhibition of human recombinant DGAT1 expressed in Sf9 cells using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counting	ChEMBL.	23541669
IC50 (binding)	= 7.1	Inhibition of MGAT2 in mouse intestinal microsomes using 2-oleyl-sn-glycerol and [14C]-oleyl-coenzyme A as substrate after 10 to 15 mins by liquid scintillation counting analysis	ChEMBL.	23541669
IC50 (binding)	= 7.3	Inhibition of human recombinant MGAT3 expressed in insect cell membrane using 2-oleyl-sn-glycerol and [14C]-oleyl-coenzyme A as substrate after 10 to 15 mins by liquid scintillation counting analysis	ChEMBL.	23541669
IC50 (binding)	= 7.9	Inhibition of MGAT2 in human intestinal microsomes using 2-oleyl-sn-glycerol and [14C]-oleyl-coenzyme A as substrate after 10 to 15 mins by liquid scintillation counting analysis	ChEMBL.	23541669
IC50 (binding)	= 8.2	Inhibition of human recombinant MGAT2 expressed in insect cell membrane using 2-oleoyl-sn-glycerol and oleoyl coenzyme A as substrate after 40 mins by Ellmans assay based rapidfire LCMS analysis	ChEMBL.	23541669
IC50 (binding)	= 8.3	Inhibition of mouse recombinant MGAT2 expressed in insect cell membrane using 2-oleoyl-sn-glycerol and oleoyl coenzyme A as substrate after 40 mins by Ellmans assay based rapidfire LCMS analysis	ChEMBL.	23541669
IC50 (binding)	= 0.01 uM	Inhibition of human MGAT2 by Rapidfire LCMS assay	ChEMBL.	No reference
Inhibition (functional)	= 116 %	Antiobesity activity in C57Bl6J mouse assessed as inhibition of corn oil-induced triacylglycerol excursion at 5 mg/kg, po administered at 30 mins post corn-oil challenge measured after 2 hrs by oral lipid tolerance test relative to control	ChEMBL.	23541669
Papp (ADMET)	= 3.3 ucm/s	Apparent permeability from apical side to basolateral side of human Caco2 cells at 10 umol/l measured up to 120 mins by LCMS analysis	ChEMBL.	23541669
Papp (ADMET)	= 8 ucm/s	Apparent permeability of the compound from apical to basolateral side in human Caco2 cells	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2376303

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1765991