Detailed information for compound 1765992

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 409.407 | Formula: C18H17F2N3O4S
  • H donors: 3 H acceptors: 4 LogP: 2.02 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@]1(C)NC(=O)c2c(NC1=O)ccc(c2)S(=O)(=O)Nc1ccc(cc1F)F
  • InChi: 1S/C18H17F2N3O4S/c1-3-18(2)17(25)21-14-7-5-11(9-12(14)16(24)22-18)28(26,27)23-15-6-4-10(19)8-13(15)20/h4-9,23H,3H2,1-2H3,(H,21,25)(H,22,24)/t18-/m1/s1
  • InChiKey: APXWBCMMYGRMJI-GOSISDBHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133242 All targets in OG5_133242
Schistosoma japonicum ko:K00736 alpha-1,6-mannosyl-glycoprotein [EC2.4.1.143], putative Get druggable targets OG5_133242 All targets in OG5_133242
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein Get druggable targets OG5_133242 All targets in OG5_133242
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II Get druggable targets OG5_133242 All targets in OG5_133242
Echinococcus granulosus alpha 16 mannosyl glycoprotein Get druggable targets OG5_133242 All targets in OG5_133242
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II Get druggable targets OG5_133242 All targets in OG5_133242
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0084 0.0811 0.0811
Schistosoma mansoni neurotransmitter gated ion channel 0.0084 0.0811 0.0811
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0081 0.0362
Trichomonas vaginalis set domain proteins, putative 0.0239 0.2632 0.8025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0081 0.0248
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0127 0.0126
Onchocerca volvulus 0.0148 0.1557 0.2248
Loa Loa (eye worm) hypothetical protein 0.0045 0.0348 0.0347
Brugia malayi CXXC zinc finger family protein 0.0029 0.0163 0.0163
Brugia malayi Bromodomain containing protein 0.0077 0.073 0.0729
Plasmodium vivax SET domain protein, putative 0.0031 0.0184 0.1082
Loa Loa (eye worm) hypothetical protein 0.0064 0.057 0.0569
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0549 0.0549
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0064 0.057 0.0569
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0081 0.0362
Schistosoma mansoni cpg binding protein 0.0032 0.0205 0.0205
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0319 0.1917
Loa Loa (eye worm) hypothetical protein 0.0026 0.0127 0.0126
Loa Loa (eye worm) hypothetical protein 0.0041 0.0306 0.0305
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.0127 0.0126
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.0127 0.0141
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0127 0.0141
Echinococcus granulosus glycine receptor subunit beta 0.0148 0.1557 0.1557
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.0081 0.0248
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0184 0.0828
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0081 0.0248
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0148 0.1557 0.1557
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0127 0.0141
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Schistosoma mansoni acetylcholine receptor-related 0.0064 0.057 0.0569
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0269 0.2988 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0081 0.0362
Onchocerca volvulus 0.0042 0.0319 0.0362
Loa Loa (eye worm) hypothetical protein 0.0128 0.1323 0.1322
Loa Loa (eye worm) hypothetical protein 0.0084 0.0811 0.0811
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0196 0.2122 0.2122
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0153 0.1626 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0127 0.0386
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0148 0.1557 0.1557
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0043 0.0333 0.155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0081 0.0248
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0148 0.1557 0.1557
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0148 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0064 0.057 0.0569
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0196 0.2122 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0148 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0042 0.0319 0.0319
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0042 0.0319 0.0319
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0319 0.1485
Brugia malayi Cathepsin L-like precursor 0.0022 0.0081 0.0081
Schistosoma mansoni nAChR subunit 0.0148 0.1557 0.1557
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0127 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0127 0.0386
Brugia malayi diacylglycerol acyltransferase 0.0153 0.1626 0.1625
Leishmania major cathepsin L-like protease 0.0022 0.0081 0.0362
Loa Loa (eye worm) hypothetical protein 0.0039 0.0278 0.0277
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0542 0.1867
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0036 0.0109
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0319 0.0973
Leishmania major glycerol uptake protein, putative 0.0026 0.0127 0.0576
Echinococcus multilocularis cysteine protease 0.0022 0.0081 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0386 0.0385
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0081
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0127 0.0126
Brugia malayi PHD-finger family protein 0.0027 0.0138 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0081 0.0362
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0542 0.0835
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.0081 0.0081
Echinococcus granulosus chromobox protein 1 0.007 0.0648 0.0647
Leishmania major cathepsin L-like protease 0.0022 0.0081 0.0362
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0249 0.0248
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0542 0.1867
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0064 0.057 0.0569
Onchocerca volvulus 0.0084 0.0811 0.1112
Loa Loa (eye worm) cysteine protease 0.0022 0.0081 0.0081
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0148 0.1557 0.1557
Brugia malayi Cathepsin L-like precursor 0.0022 0.0081 0.0081
Entamoeba histolytica hypothetical protein 0.0084 0.0811 0.2281
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0542 0.0541
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.328 1
Leishmania major diacylglycerol acyltransferase, putative 0.0043 0.0333 0.155
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0542 0.2536
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0081 0.0362
Brugia malayi Cation transporter family protein 0.0148 0.1557 0.1557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0081 0.0362
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0148 0.1557 0.1557
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0153 0.1626 0.1625
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.139 0.4238
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0043 0.0333 0.155
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0009 0.0009
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.1512 1
Echinococcus multilocularis geminin 0.0171 0.1828 0.1827
Leishmania major cathepsin L-like protease 0.0022 0.0081 0.0362
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0319 0.0319
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.0127 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0081 0.0248
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0386 0.0385
Leishmania major hypothetical protein, unknown function,protein, unknown function 0.0043 0.0333 0.155
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0064 0.057 0.0569
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0127 0.0126
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0148 0.1557 0.1557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0081 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.139 0.4238
Onchocerca volvulus 0.0581 0.6646 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0186 0.0185
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0148 0.1557 0.1557
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0127 0.0126
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.0081 0.0081
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0026 0.0127 0.0126
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0036 0.0109
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.0081 0.0362
Onchocerca volvulus 0.0064 0.057 0.0744
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0319 0.0973
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0127 0.0126
Brugia malayi Hhat protein 0.0026 0.0127 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.139 0.4238
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0043 0.0333 0.155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0081 0.0248
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.328 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0542 0.1867
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0148 0.1557 0.1557
Leishmania major cathepsin L-like protease 0.0022 0.0081 0.0362
Loa Loa (eye worm) hypothetical protein 0.0064 0.057 0.0569
Brugia malayi excitatory GABA receptor EXP-1A 0.0148 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0064 0.057 0.0569
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0009 0.0009
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.0127 0.0126
Leishmania major hypothetical protein, conserved 0.0042 0.0319 0.1485
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0519 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0151 0.046
Loa Loa (eye worm) hypothetical protein 0.0084 0.0811 0.0811
Brugia malayi Heterochromatin protein 1 0.007 0.0648 0.0647
Brugia malayi beta-lactamase 0.0042 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0026 0.0127 0.0126
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0196 0.2122 0.2122
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.0081 0.0081
Leishmania major cathepsin L-like protease 0.0022 0.0081 0.0362
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0051 0.0051
Echinococcus granulosus cathepsin l1 0.0022 0.0081 0.0081
Brugia malayi chromobox protein homolog 3 0.0039 0.0286 0.0285
Loa Loa (eye worm) hhat protein 0.0026 0.0127 0.0126
Onchocerca volvulus 0.0064 0.057 0.0744
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0148 0.1557 0.1557
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.0127 0.0386
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0153 0.1626 0.1625
Leishmania major diacylglycerol acyltransferase, putative 0.0196 0.2122 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0319 0.0319
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0043 0.0333 0.0332
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0319 0.1485
Schistosoma mansoni nAChR subunit 0.0064 0.057 0.0569
Brugia malayi Pre-SET motif family protein 0.021 0.2292 0.2292
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0064 0.057 0.0569
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.0866 1 1
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0043 0.0333 0.155
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.139 0.4238
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.0081 0.0081
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0036 0.0109
Echinococcus granulosus nAChR subunit 0.0148 0.1557 0.1557
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0081 0.0248
Schistosoma mansoni cpg binding protein 0.0032 0.0205 0.0205
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0581 0.6646 0.6646
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0127 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0081 0.0248
Loa Loa (eye worm) hypothetical protein 0.0064 0.057 0.0569
Loa Loa (eye worm) ACC-1 protein 0.0148 0.1557 0.1557
Brugia malayi Pre-SET motif family protein 0.0031 0.0184 0.0184
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0081 0.0248
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0127 0.0126
Leishmania major cysteine peptidase A (CPA) 0.0022 0.0081 0.0362
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0081 0.0248
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0319 0.0973
Schistosoma mansoni hypothetical protein 0.0021 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0064 0.057 0.0569
Schistosoma mansoni bromodomain containing protein 0.0065 0.0592 0.0591
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0286 0.0311
Schistosoma mansoni hypothetical protein 0.0015 0.0005 0.0004
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.0127 0.0126
Onchocerca volvulus 0.0581 0.6646 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.011 0.0109
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0009 0.0021
Schistosoma mansoni nAChR subunit 0.0148 0.1557 0.1557
Schistosoma mansoni neurotransmitter gated ion channel 0.0064 0.057 0.0569
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0009 0.0009
Loa Loa (eye worm) beta-lactamase 0.0042 0.0319 0.0319
Echinococcus multilocularis nAChR subunit 0.0084 0.0811 0.0811
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0148 0.1557 0.1557
Schistosoma mansoni nAChR subunit 0.0064 0.057 0.0569
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0148 0.1557 0.1557
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0153 0.1626 0.1625
Leishmania major glycerol uptake protein, putative 0.0026 0.0127 0.0576
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0148 0.1557 0.1557
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0081 0.0081
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Echinococcus granulosus glycine receptor subunit alpha 1 0.0148 0.1557 0.1557
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0009 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0081 0.0362
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0084 0.0811 0.0811
Loa Loa (eye worm) ctsf protein 0.0022 0.0081 0.0081
Echinococcus granulosus nAChR subunit 0.0084 0.0811 0.0811
Brugia malayi jmjC domain containing protein 0.0016 0.0009 0.0009
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0009 0.0009
Echinococcus granulosus cathepsin l cysteine peptidase 0.0022 0.0081 0.0081
Brugia malayi jmjC domain containing protein 0.0063 0.0561 0.0561
Plasmodium vivax vivapain-2 0.0022 0.0081 0.0446
Leishmania major cathepsin L-like protease 0.0022 0.0081 0.0362
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.0127 0.0126
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0542 0.0541
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0081 0.0248
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0148 0.1557 0.1557
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0148 0.1557 0.1557
Echinococcus multilocularis chromobox protein 1 0.007 0.0648 0.0647
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0081 0.0248
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0084 0.0811 0.0811
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0022 0.0081 0.0081
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.0127 0.0126
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.328 1
Schistosoma mansoni nAChR subunit 0.0148 0.1557 0.1557
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0542 0.0541
Brugia malayi hypothetical protein 0.0064 0.057 0.0569
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0561 0.0561
Onchocerca volvulus 0.0031 0.0186 0.0159
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0009
Echinococcus granulosus zinc finger protein 0.0021 0.0075 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0081 0.0362
Loa Loa (eye worm) hypothetical protein 0.0064 0.057 0.0569
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0779 0.2375
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0148 0.1557 0.1557
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.0127 0.0126
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0127 0.0576
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0249 0.0248
Trichomonas vaginalis chromobox protein, putative 0.007 0.0648 0.1975
Schistosoma mansoni chromobox protein 0.007 0.0648 0.0647
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.0127 0.0126
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0127 0.0576
Leishmania major glycerol uptake protein, putative 0.0026 0.0127 0.0576
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0036 0.0109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.328 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0081 0.0248
Entamoeba histolytica hypothetical protein 0.0026 0.0127 0.0141
Echinococcus multilocularis glycine receptor subunit beta 0.0148 0.1557 0.1557
Loa Loa (eye worm) acetylcholine receptor protein 0.0064 0.057 0.0569
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0009 0.0009
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0148 0.1557 0.1557
Brugia malayi hypothetical protein 0.0064 0.057 0.0569
Loa Loa (eye worm) GABA receptor subunit 0.0084 0.0811 0.0811
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0153 0.1626 0.765
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.057 0.0569
Trichomonas vaginalis porcupine, putative 0.0026 0.0127 0.0386
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0036 0.0109
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0386 0.0385
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Onchocerca volvulus 0.0148 0.1557 0.2248
Loa Loa (eye worm) hypothetical protein 0.0064 0.057 0.0569
Brugia malayi Cathepsin L-like precursor 0.0022 0.0081 0.0081
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.1557 0.1557
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0519 0.0519
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0561 0.0561
Brugia malayi Cathepsin L-like precursor 0.0022 0.0081 0.0081
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0127 0.0126
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0033 0.0032
Onchocerca volvulus 0.0042 0.0319 0.0362
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0148 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0064 0.057 0.0569
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0286 0.0871
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0043 0.0333 0.0332
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0081 0.0362
Onchocerca volvulus 0.0029 0.0163 0.0125
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0009 0.0009
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0148 0.1557 0.1557
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0196 0.2122 1
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0042 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0127 0.0386
Onchocerca volvulus 0.0064 0.057 0.0744
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0081 0.0362
Trypanosoma cruzi GUP1, putative 0.0026 0.0127 0.0576
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0508 0.2361
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0081 0.0362
Schistosoma mansoni nAChR subunit 0.0148 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0581 0.6646 0.6646
Plasmodium falciparum cysteine proteinase falcipain 3 0.0022 0.0081 0.0446
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0009 0.0021
Brugia malayi jmjC domain containing protein 0.0016 0.0009 0.0009
Schistosoma mansoni zinc finger protein 0.0015 0.0005 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0036 0.0109
Loa Loa (eye worm) hypothetical protein 0.0517 0.59 0.59
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0148 0.1557 0.1557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0081 0.0362
Echinococcus granulosus phd:f box containing protein 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0084 0.0811 0.0811
Echinococcus granulosus glycine receptor subunit alpha 1 0.0148 0.1557 0.1557
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.1512 1
Schistosoma mansoni nAChR subunit 0.0148 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0084 0.0811 0.0811
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0026 0.0025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0319 0.0319
Loa Loa (eye worm) hhat protein 0.0026 0.0127 0.0126
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.0127 0.0126
Brugia malayi MBOAT family protein 0.0026 0.0127 0.0126
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0026 0.0025
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0084 0.0811 0.0811
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0009 0.0021
Schistosoma mansoni cpg binding protein 0.0029 0.0163 0.0163
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0581 0.6646 0.6646
Leishmania major diacylglycerol acyltransferase, putative 0.0043 0.0333 0.155
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0148 0.1557 0.1557
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0127 0.0126
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0319 0.1485
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0148 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.328 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Echinococcus granulosus geminin 0.0171 0.1828 0.1827
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.0127 0.0126
Schistosoma mansoni neurotransmitter gated ion channel 0.0064 0.057 0.0569
Brugia malayi Bromodomain containing protein 0.0039 0.0277 0.0276
Onchocerca volvulus 0.0148 0.1557 0.2248
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0319 0.0318
Onchocerca volvulus Putative nachr subunit 0.0148 0.1557 0.2248
Brugia malayi jmjC domain containing protein 0.0059 0.0519 0.0519
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0084 0.0811 0.0811
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0081 0.0248
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.139 0.4238
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0319 0.0319
Echinococcus granulosus chromobox protein 1 0.007 0.0648 0.0647
Schistosoma mansoni chromobox protein 0.007 0.0648 0.0647
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0084 0.0811 0.0811
Schistosoma mansoni acetylcholine receptor subunit beta 0.0064 0.057 0.0569
Brugia malayi hypothetical protein 0.0064 0.057 0.0569
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0009
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0148 0.1557 0.1557
Brugia malayi beta-lactamase family protein 0.0042 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0039 0.0286 0.0285
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0148 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0084 0.0811 0.0811
Schistosoma mansoni nAChR subunit 0.0148 0.1557 0.1557
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0148 0.1557 0.1557
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0386 0.0385
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.4661 0.466
Brugia malayi jmjC domain containing protein 0.0016 0.0009 0.0009
Schistosoma mansoni zinc finger protein 0.0021 0.0075 0.0074
Loa Loa (eye worm) hypothetical protein 0.0064 0.057 0.0569
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0036 0.0109
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0321 0.0364
Trichomonas vaginalis esterase, putative 0.0042 0.0319 0.0973
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.328 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0148 0.1557 0.1557
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0051 0.0051
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.0127 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.139 0.4238
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0009 0.0009
Onchocerca volvulus 0.0026 0.0127 0.0069
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0153 0.1626 0.765
Onchocerca volvulus 0.0239 0.2632 0.3886
Toxoplasma gondii hypothetical protein 0.0052 0.0435 0.2015
Echinococcus multilocularis cysteine protease 0.0022 0.0081 0.0081
Brugia malayi Cathepsin L-like precursor 0.0022 0.0081 0.0081
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.1512 0.447
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0064 0.057 0.0569
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0064 0.057 0.0569
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0081 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0184 0.0184
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0064 0.057 0.0569
Brugia malayi MBOAT family protein 0.0026 0.0127 0.0126
Onchocerca volvulus 0.0084 0.0811 0.1112
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0148 0.1557 0.1557
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.0081 0.0081
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.011 0.0109
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.1557 0.1557
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0866 1 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0064 0.057 0.0569
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0081 0.0248
Brugia malayi Cation transporter family protein 0.0581 0.6646 0.6646
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0081 0.0248
Loa Loa (eye worm) fibroinase 0.0022 0.0081 0.0081
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0196 0.2122 1
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0081 0.0362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0081 0.0248
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0148 0.1557 0.1557
Echinococcus granulosus cpg binding protein 0.0032 0.0205 0.0205
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0127 0.0126
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0321 0.0978
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0148 0.1557 0.1557
Echinococcus multilocularis zinc finger protein 0.0021 0.0075 0.0074
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0148 0.1557 0.1557
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0127 0.0576
Brugia malayi MBOAT family protein 0.0026 0.0127 0.0126
Loa Loa (eye worm) hypothetical protein 0.0084 0.0811 0.0811
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.328 1
Echinococcus granulosus glycine receptor subunit beta 0.0148 0.1557 0.1557
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0319 0.0973
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.328 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0081 0.0362
Loa Loa (eye worm) LGC-31 protein 0.0148 0.1557 0.1557
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0151 0.046
Schistosoma mansoni sterol O-acyltransferase 1 0.0026 0.0127 0.0126
Brugia malayi beta-lactamase family protein 0.0042 0.0319 0.0319
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0009 0.0009
Leishmania major cathepsin L-like protease 0.0022 0.0081 0.0362
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0009
Brugia malayi hypothetical protein 0.0064 0.057 0.0569
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0319 0.0973
Leishmania major hypothetical protein, conserved 0.0016 0.0009 0.0021
Brugia malayi jmjC domain containing protein 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0064 0.057 0.0569
Brugia malayi MBOAT family protein 0.0026 0.0127 0.0126
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0127 0.0576
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0163 0.0163
Toxoplasma gondii hypothetical protein 0.0026 0.0127 0.0556
Loa Loa (eye worm) hypothetical protein 0.0026 0.0127 0.0126
Toxoplasma gondii mono- or diacylglycerol acyltransferase 0.0043 0.0333 0.1532
Onchocerca volvulus 0.0042 0.0319 0.0362
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.1557 0.1557
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0148 0.1557 0.1557
Echinococcus multilocularis nAChR subunit 0.0148 0.1557 0.1557
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0081 0.0248
Loa Loa (eye worm) hypothetical protein 0.0064 0.057 0.0569
Brugia malayi Cathepsin L-like precursor 0.0022 0.0081 0.0081
Echinococcus multilocularis cpg binding protein 0.0032 0.0205 0.0205
Schistosoma mansoni hypothetical protein 0.0171 0.1828 0.1827
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2292 0.2292
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.0081 0.0248
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0127 0.0576
Trypanosoma cruzi GUP1, putative 0.0026 0.0127 0.0576
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0009 0.0009
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0127 0.0141
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0519 0.0519
Mycobacterium ulcerans hypothetical protein 0.0043 0.0333 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0081 0.0248
Plasmodium vivax vivapain-2 0.0022 0.0081 0.0446
Schistosoma mansoni nAChR subunit 0.0148 0.1557 0.1557
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.0866 1 1
Leishmania major glycerol uptake protein, putative 0.0026 0.0127 0.0576
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0153 0.1626 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.011 0.0109
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0042 0.0319 0.0319
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0081 0.0248
Schistosoma mansoni hypothetical protein 0.0412 0.4661 0.466
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0064 0.057 0.0569
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.057 0.0569
Schistosoma mansoni zinc finger protein 0.0026 0.0127 0.0126
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0648 0.0647
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0148 0.1557 0.1557
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.328 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0022 0.0081 0.0446
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0385
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0026 0.0025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0081 0.0248
Echinococcus granulosus dnaJ subfamily B 0.0412 0.4661 0.466
Schistosoma mansoni hypothetical protein 0.0171 0.1828 0.1827
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0519 0.0519
Echinococcus multilocularis glycine receptor subunit beta 0.0148 0.1557 0.1557
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.1557 0.1557
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0286 0.0871
Loa Loa (eye worm) hypothetical protein 0.0042 0.0319 0.0319
Echinococcus multilocularis sterol O acyltransferase 1 0.0026 0.0127 0.0126
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0164 0.0163
Leishmania major cathepsin L-like protease 0.0022 0.0081 0.0362
Leishmania major glycerol uptake protein, putative 0.0026 0.0127 0.0576
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0084 0.0811 0.0811
Loa Loa (eye worm) hypothetical protein 0.0071 0.066 0.066
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0009 0.0009
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0148 0.1557 0.1557
Echinococcus granulosus glycine receptor subunit alpha 1 0.0148 0.1557 0.1557
Onchocerca volvulus 0.0196 0.2122 0.3109
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0542 0.252
Loa Loa (eye worm) hypothetical protein 0.0064 0.057 0.0569
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.1557 0.1557
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0319 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.139 0.4238
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.328 1
Onchocerca volvulus 0.0581 0.6646 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0148 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0022 0.0081 0.0446
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0084 0.0811 0.0811
Loa Loa (eye worm) ACC-1 protein 0.0148 0.1557 0.1557
Echinococcus granulosus cathepsin L cysteine proteinase 0.0022 0.0081 0.0081
Onchocerca volvulus 0.0042 0.0319 0.0362
Echinococcus multilocularis chromobox protein 1 0.007 0.0648 0.0647
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0319 0.0319
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.057 0.0569
Toxoplasma gondii dgat2l1-prov protein 0.0196 0.2122 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0561 0.0561
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0148 0.1557 0.1557
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0184 0.0184
Brugia malayi Cation transporter family protein 0.0148 0.1557 0.1557
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0127 0.0126
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0148 0.1557 0.1557
Brugia malayi diacylglycerol acyltransferase family protein 0.0196 0.2122 0.2122
Trichomonas vaginalis chromobox protein, putative 0.007 0.0648 0.1975
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0127 0.0141
Loa Loa (eye worm) hypothetical protein 0.0148 0.1557 0.1557
Toxoplasma gondii cathepsin CPL 0.0022 0.0081 0.0342
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.0866 1 1
Echinococcus granulosus sterol O acyltransferase 1 0.0026 0.0127 0.0126
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0153 0.1626 0.1625
Leishmania major hypothetical protein, conserved 0.0026 0.0127 0.0576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0081 0.0248
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.328 1
Toxoplasma gondii diacylglycerol acyltransferase 0.0043 0.0333 0.1532
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0148 0.1557 0.1557
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0542 0.0541
Toxoplasma gondii ABC1 family protein 0.0042 0.0319 0.1466
Brugia malayi MBOAT family protein 0.0026 0.0127 0.0126
Loa Loa (eye worm) hypothetical protein 0.0064 0.057 0.0569
Loa Loa (eye worm) hypothetical protein 0.0026 0.0127 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.139 0.4238
Brugia malayi hypothetical protein 0.0064 0.057 0.0569
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.1557 0.1557
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0081 0.0248
Loa Loa (eye worm) hypothetical protein 0.0064 0.057 0.0569
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0081 0.0248
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0557 0.0557
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0043 0.0333 0.155
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0043 0.0333 0.0332
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0064 0.057 0.0569
Loa Loa (eye worm) hypothetical protein 0.0581 0.6646 0.6646
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0036 0.0109
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0321 0.0978
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.328 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.2 Inhibition of human recombinant MGAT2 expressed in insect cell membrane using 2-oleoyl-sn-glycerol and oleoyl coenzyme A as substrate after 40 mins by Ellmans assay based rapidfire LCMS analysis ChEMBL. 23541669

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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