Detailed information for compound 1789531

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 295.293 | Formula: C16H13N3O3
  • H donors: 3 H acceptors: 3 LogP: 1.17 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1O)C1Nn2c(C1)nc1c(c2=O)cccc1
  • InChi: 1S/C16H13N3O3/c20-13-6-5-9(7-14(13)21)12-8-15-17-11-4-2-1-3-10(11)16(22)19(15)18-12/h1-7,12,18,20-21H,8H2
  • InChiKey: QRNJPRNLVITJAH-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0026 0.0034 0.0133
Brugia malayi Protein kinase domain containing protein 0.0026 0.0034 0.0032
Entamoeba histolytica protein kinase, putative 0.0346 0.1467 0.8459
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0056 0.0055
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0011 0.0014
Mycobacterium tuberculosis Conserved protein 0.0074 0.0248 0.1224
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Entamoeba histolytica cell division protein kinase 2, putative 0.0405 0.1732 1
Brugia malayi beta-lactamase family protein 0.0074 0.0248 0.0246
Loa Loa (eye worm) cyclin domain-containing protein 0.0061 0.0192 0.019
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0248 0.1388
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0136 0.0727
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0011 0.0033
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0248 0.1224
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0242 0.1071
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0248 0.1376
Schistosoma mansoni regulator of G protein signaling 0.0079 0.0272 0.0807
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0014
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0061 0.0192 0.0928
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0142 0.0772
Onchocerca volvulus 0.0078 0.0266 0.1171
Schistosoma mansoni cyclin G 0.0061 0.0192 0.0569
Echinococcus multilocularis smad 0.0042 0.0106 0.0285
Loa Loa (eye worm) Smad1 0.0042 0.0106 0.0104
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0042 0.0911
Schistosoma mansoni lamin 0.0058 0.0176 0.0524
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0405 0.1732 0.173
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0026 0.0034 0.0133
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0009
Brugia malayi MH1 domain containing protein 0.0023 0.0022 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0092 0.0405
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0042 0.0207
Echinococcus granulosus cyclin y 0.0061 0.0192 0.0569
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0192 0.0848
Leishmania major mitotic cyclin, putative 0.0061 0.0192 0.1049
Echinococcus granulosus lamin 0.0058 0.0176 0.0524
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0534 0.0532
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Loa Loa (eye worm) hypothetical protein 0.003 0.0054 0.0052
Onchocerca volvulus Cyclin L homolog 0.0061 0.0192 0.084
Brugia malayi Regulator of G protein signaling domain containing protein 0.0079 0.0272 0.027
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0248 0.0737
Echinococcus granulosus cyclins 0.0253 0.1051 0.3123
Onchocerca volvulus 0.0058 0.0176 0.0772
Schistosoma mansoni hypothetical protein 0.0708 0.3084 0.9164
Plasmodium falciparum serine/threonine protein kinase, putative 0.0346 0.1467 0.8459
Entamoeba histolytica protein kinase, putative 0.0346 0.1467 0.8459
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0026 0.0034 0.0133
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0011 0.0009
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0054 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.0405 0.1732 0.5147
Entamoeba histolytica cyclin C, putative 0.0061 0.0192 0.1049
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0198 0.0196
Echinococcus multilocularis cyclin dependent kinase 1 0.0405 0.1732 0.467
Entamoeba histolytica hypothetical protein 0.0079 0.0272 0.1514
Echinococcus multilocularis cyclin A3 4 0.0061 0.0192 0.0517
Schistosoma mansoni DNA polymerase eta 0.0021 0.0011 0.0033
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0092 0.0469
Trypanosoma cruzi mitotic cyclin, putative 0.0061 0.0192 0.1049
Giardia lamblia Cyclin A 0.0253 0.1051 0.6043
Brugia malayi Cyclin C 0.0061 0.0192 0.019
Brugia malayi Cyclin, N-terminal domain containing protein 0.0061 0.0192 0.019
Toxoplasma gondii cyclin dependent kinase binding protein 0.0061 0.0192 0.0928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0047 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.008 0.0355
Trichomonas vaginalis cyclins, putative 0.0061 0.0192 0.0848
Onchocerca volvulus 0.0377 0.1604 0.7094
Entamoeba histolytica p21-activated kinase 0.0026 0.0034 0.0133
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0054 0.0052
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0213 0.0575
Brugia malayi hypothetical protein 0.0115 0.0431 0.0429
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0534 0.1439
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0082 0.0222
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0459 0.2267
Brugia malayi chromobox protein homolog 3 0.0041 0.01 0.0098
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0362 0.0977
Plasmodium falciparum thioredoxin reductase 0.0048 0.0131 0.0702
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0011 0.0049
Loa Loa (eye worm) cyclin C 0.0061 0.0192 0.019
Trypanosoma cruzi mitotic cyclin, putative 0.0061 0.0192 0.1049
Echinococcus multilocularis regulator of G protein signaling 7 0.0079 0.0272 0.0732
Mycobacterium ulcerans beta-lactamase 0.0074 0.0248 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0176 0.0174
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0143 0.0141
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0011 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0136 0.0602
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0213 0.0634
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0011 0.0446
Brugia malayi MH1 domain containing protein 0.0023 0.0022 0.002
Entamoeba histolytica cyclin family protein 0.0253 0.1051 0.6043
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0079 0.0272 0.0807
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0253 0.1051 0.3123
Loa Loa (eye worm) hypothetical protein 0.005 0.0143 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0092 0.0405
Plasmodium falciparum glutathione reductase 0.0048 0.0131 0.0702
Brugia malayi Smad1 0.0042 0.0106 0.0104
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0405 0.1732 0.173
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0248 0.1096
Giardia lamblia Aurora kinase 0.0346 0.1467 0.8459
Echinococcus multilocularis Cyclin L1 0.0061 0.0192 0.0517
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0136 0.0727
Loa Loa (eye worm) hypothetical protein 0.0092 0.0328 0.0326
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0534 0.1586
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Plasmodium falciparum cyclin 0.0253 0.1051 0.6045
Trichomonas vaginalis AGC family protein kinase 0.0346 0.1467 0.6488
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Entamoeba histolytica hypothetical protein 0.0026 0.0034 0.0133
Leishmania major trypanothione reductase 0.0048 0.0131 0.07
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0142 0.0635
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0114 0.0494
Loa Loa (eye worm) hypothetical protein 0.0074 0.0248 0.0246
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.004
Echinococcus granulosus dna polymerase kappa 0.0021 0.0011 0.0033
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0459 0.2267
Trichomonas vaginalis cyclin B3, putative 0.0061 0.0192 0.0848
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0014
Trypanosoma brucei rac serine-threonine kinase, putative 0.0026 0.0034 0.0146
Onchocerca volvulus 0.0053 0.0156 0.068
Entamoeba histolytica cyclin, domain containing protein 0.0061 0.0192 0.1049
Entamoeba histolytica protein kinase, putative 0.0026 0.0034 0.0133
Giardia lamblia Hypothetical protein 0.0253 0.1051 0.6043
Trichomonas vaginalis esterase, putative 0.0074 0.0248 0.1096
Schistosoma mansoni regulator of G protein signaling 0.0079 0.0272 0.0807
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Echinococcus multilocularis regulator of G protein signaling 3 0.0079 0.0272 0.0732
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.008 0.0355
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0026 0.0034 0.0133
Echinococcus multilocularis beta adrenergic receptor kinase 0.0771 0.3365 0.9074
Brugia malayi intermediate filament protein 0.0058 0.0176 0.0174
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0011 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0192 0.1049
Echinococcus granulosus peregrin 0.003 0.0054 0.016
Echinococcus multilocularis chromobox protein 1 0.0072 0.0242 0.0653
Trypanosoma cruzi cdc2-related kinase 3 0.0405 0.1732 1
Trypanosoma cruzi cdc2-related kinase 1 0.0405 0.1732 1
Entamoeba histolytica protein kinase , putative 0.0346 0.1467 0.8459
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Echinococcus multilocularis cyclin G2 0.0061 0.0192 0.0517
Loa Loa (eye worm) AUR protein kinase 0.0346 0.1467 0.1465
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Onchocerca volvulus 0.0028 0.0042 0.0177
Trichomonas vaginalis set domain proteins, putative 0.0524 0.226 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.008 0.0355
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0213 0.0634
Mycobacterium ulcerans hypothetical protein 0.0028 0.0042 0.1688
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0459 0.2267
Onchocerca volvulus 0.0032 0.0061 0.026
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0079 0.0272 0.0807
Entamoeba histolytica PH domain containing protein kinase, putative 0.0026 0.0034 0.0133
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0042 0.0207
Echinococcus granulosus Regulator of G protein signaling 20 0.0079 0.0272 0.0807
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0207
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0248 0.54
Treponema pallidum bacterioferrin (TpF1) 0.0018 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0192 0.0848
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0136 0.0739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0092 0.0405
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0011 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Entamoeba histolytica protein kinase, putative 0.0026 0.0034 0.0133
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0405 0.8817
Echinococcus multilocularis regulator of G protein signaling 0.0079 0.0272 0.0732
Trypanosoma brucei cyclin 3 0.0061 0.0192 0.1061
Plasmodium falciparum calcium-dependent protein kinase 7 0.0026 0.0034 0.0136
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0021 0.0073
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0072 0.007
Giardia lamblia Hypothetical protein 0.0061 0.0192 0.1049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0047 0.0209
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0242 0.024
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0042 0.0179
Loa Loa (eye worm) AGC/AKT protein kinase 0.0026 0.0034 0.0032
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0131 0.0355
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0136 0.0134
Brugia malayi regulator of G-protein signaling egl-10 0.0079 0.0272 0.027
Leishmania major cyclin 9, putative 0.0061 0.0192 0.1049
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0042 0.1688
Schistosoma mansoni cyclin k 0.0061 0.0192 0.0569
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0047 0.0207
Giardia lamblia Cyclin B-like protein 0.0061 0.0192 0.1049
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0054 0.0117
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0248 0.1096
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0142 0.0759
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0006 0.0027
Leishmania major protein kinase, putative 0.0346 0.1467 0.8459
Brugia malayi Cyclin, N-terminal domain containing protein 0.0061 0.0192 0.019
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0054 0.016
Loa Loa (eye worm) hypothetical protein 0.0057 0.0172 0.017
Echinococcus granulosus chromobox protein 1 0.0072 0.0242 0.072
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0131 0.0649
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0 0.5
Plasmodium vivax cyclin 4, putative 0.0061 0.0192 0.1052
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0136 0.0405
Brugia malayi hypothetical protein 0.0061 0.0192 0.019
Trypanosoma cruzi cyclin, putative 0.0377 0.1604 0.9258
Loa Loa (eye worm) hypothetical protein 0.0074 0.0248 0.0246
Loa Loa (eye worm) hypothetical protein 0.0079 0.0272 0.027
Brugia malayi Cyclin, N-terminal domain containing protein 0.0061 0.0192 0.019
Brugia malayi MH1 domain containing protein 0.0042 0.0106 0.0104
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0036
Brugia malayi regulator of G-protein signaling rgs-7 0.0079 0.0272 0.027
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0018 0.005
Schistosoma mansoni cyclin l 0.0061 0.0192 0.0569
Brugia malayi cyclin fold protein 1 variant b 0.0061 0.0192 0.019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0009
Brugia malayi hypothetical protein 0.005 0.0142 0.014
Trypanosoma brucei cdc2-related kinase 3 0.0405 0.1732 1
Entamoeba histolytica protein kinase, putative 0.0026 0.0034 0.0133
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0011 0.003
Echinococcus granulosus cyclin G2 0.0061 0.0192 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0064 0.0285
Toxoplasma gondii hypothetical protein 0.0192 0.0778 0.438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0036 0.0159
Trichomonas vaginalis CMGC family protein kinase 0.0405 0.1732 0.7662
Plasmodium vivax hypothetical protein, conserved 0.003 0.0054 0.0251
Plasmodium falciparum cyclin 1 0.0061 0.0192 0.1052
Onchocerca volvulus 0.0058 0.0176 0.0772
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.004
Echinococcus multilocularis cyclin B 0.0377 0.1604 0.4326
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0061 0.0192 0.0517
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0042 0.0179
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0203 0.0602
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0026 0.0034 0.0133
Onchocerca volvulus 0.0074 0.0248 0.1089
Echinococcus granulosus beta-adrenergic receptor kinase 0.0771 0.3365 1
Trypanosoma brucei mitotic cyclin 0.0061 0.0192 0.1061
Echinococcus multilocularis cyclin b3 0.0253 0.1051 0.2834
Toxoplasma gondii ABC1 family protein 0.0074 0.0248 0.126
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0026 0.0034 0.0133
Loa Loa (eye worm) hypothetical protein 0.0061 0.0192 0.019
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0042 0.0179
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Schistosoma mansoni cyclin B3 0.0253 0.1051 0.3123
Giardia lamblia G2/mitotic-specific cyclin B 0.0377 0.1604 0.9258
Trypanosoma cruzi cyclin 9, putative 0.0061 0.0192 0.1049
Echinococcus multilocularis cyclins 0.0253 0.1051 0.2834
Schistosoma mansoni serine/threonine protein kinase 0.0771 0.3365 1
Echinococcus multilocularis expressed protein 0.0079 0.0272 0.0732
Echinococcus multilocularis geminin 0.0708 0.3084 0.8316
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0006 0.0027
Echinococcus granulosus cyclin 0.0061 0.0192 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0092 0.0405
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0011 0.5
Leishmania major serine/threonine-protein kinase a, putative 0.0026 0.0034 0.0133
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0042 0.1688
Trichomonas vaginalis cyclin B, putative 0.0061 0.0192 0.0848
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0242 0.1071
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0042 0.1688
Loa Loa (eye worm) hypothetical protein 0.0124 0.0471 0.0469
Loa Loa (eye worm) hypothetical protein 0.0079 0.0272 0.027
Trypanosoma cruzi NIMA-related kinase, putative 0.0026 0.0034 0.0133
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0061 0.0192 0.1052
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.0431 0.128
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0312 0.0926
Loa Loa (eye worm) CYL-1 protein 0.0061 0.0192 0.019
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0405 0.1999
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0014
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0079 0.0272 0.0732
Echinococcus multilocularis cyclins 0.0253 0.1051 0.2834
Plasmodium vivax glutathione reductase, putative 0.0048 0.0131 0.0702
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Entamoeba histolytica hypothetical protein 0.0026 0.0034 0.0133
Mycobacterium ulcerans hypothetical protein 0.0074 0.0248 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0248 0.0246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.008 0.0355
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0534 0.0532
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0131 0.013
Schistosoma mansoni serine/threonine protein kinase 0.0405 0.1732 0.5147
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0014
Onchocerca volvulus 0.0074 0.0248 0.1089
Echinococcus granulosus Smad4 0.0042 0.0106 0.0314
Entamoeba histolytica cyclin, domain containing protein 0.0061 0.0192 0.1049
Echinococcus granulosus axis inhibition protein axin 0.0079 0.0272 0.0807
Giardia lamblia PHD finger protein 15 0.003 0.0054 0.0248
Schistosoma mansoni Smad4 0.0019 0.0002 0.0006
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0136 0.0727
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0248 0.1224
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0405 0.1999
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0006 0.0027
Entamoeba histolytica hypothetical protein 0.0115 0.0431 0.2439
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0142 0.0762
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0248 0.1096
Brugia malayi Pre-SET motif family protein 0.046 0.1976 0.1975
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.008 0.0355
Mycobacterium tuberculosis Probable reductase 0.0109 0.0405 0.1999
Brugia malayi Cyclin, N-terminal domain containing protein 0.0061 0.0192 0.019
Trypanosoma brucei aurora B kinase 0.0346 0.1467 0.8461
Loa Loa (eye worm) hypothetical protein 0.0079 0.0272 0.027
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0248 0.0737
Schistosoma mansoni protein kinase 0.0346 0.1467 0.4359
Echinococcus multilocularis Regulator of G protein signaling 20 0.0079 0.0272 0.0732
Schistosoma mansoni intermediate filament proteins 0.0058 0.0176 0.0524
Mycobacterium leprae Probable lipase LipE 0.0074 0.0248 0.54
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0106 0.0314
Echinococcus granulosus G1:S specific cyclin D1 0.0061 0.0192 0.0569
Entamoeba histolytica PH domain containing protein kinase, putative 0.0026 0.0034 0.0133
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0042 0.0179
Echinococcus multilocularis cyclins 0.0253 0.1051 0.2834
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0106 0.0285
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0026 0.0034 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0048 0.0214
Trichomonas vaginalis cyclin D, putative 0.0253 0.1051 0.465
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0026 0.0034 0.0146
Schistosoma mansoni serine/threonine-protein kinase 0.0026 0.0034 0.0101
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0471 0.2024 1
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0272 0.1201
Entamoeba histolytica cell division protein kinase 2, putative 0.0405 0.1732 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0061 0.0192 0.019
Toxoplasma gondii thioredoxin reductase 0.0048 0.0131 0.0574
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0026 0.0034 0.0133
Echinococcus multilocularis regulator of G protein signaling 3 0.0079 0.0272 0.0732
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.007
Entamoeba histolytica PH domain containing protein kinase, putative 0.0026 0.0034 0.0133
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.0431 0.1162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0036 0.0159
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0061 0.0192 0.0569
Loa Loa (eye worm) cyclin domain-containing protein 0.2254 1 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0042 0.0911
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0272 0.1201
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0061 0.0192 0.0517
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0847 0.3708 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0074 0.0248 0.0246
Schistosoma mansoni smad1 5 8 and 0.0042 0.0106 0.0314
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0061 0.0192 0.1052
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0248 0.1224
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0011 0.0055
Echinococcus granulosus cyclin B3 1 0.0253 0.1051 0.3123
Schistosoma mansoni hypothetical protein 0.0061 0.0192 0.0569
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0131 0.07
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0026 0.0034 0.015
Echinococcus granulosus cyclin b3 0.0253 0.1051 0.3123
Brugia malayi PXA domain containing protein 0.0079 0.0272 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0272 0.1201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0036 0.0159
Loa Loa (eye worm) hypothetical protein 0.0079 0.0272 0.027
Brugia malayi beta-lactamase family protein 0.0074 0.0248 0.0246
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0054 0.016
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0459 1
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0346 0.1467 0.3955
Brugia malayi MH2 domain containing protein 0.0615 0.2668 0.2666
Plasmodium vivax protein kinase Crk2 0.0405 0.1732 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0136 0.0727
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0042 0.004
Echinococcus multilocularis lamin dm0 0.0058 0.0176 0.0476
Brugia malayi serine/threonine-protein kinase 6 0.0346 0.1467 0.1465
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0106 0.0104
Echinococcus granulosus cyclin t1 0.0061 0.0192 0.0569
Trypanosoma brucei protein kinase, putative 0.0026 0.0034 0.0146
Mycobacterium tuberculosis Conserved protein 0.0074 0.0248 0.1224
Entamoeba histolytica cyclin family protein 0.0253 0.1051 0.6043
Echinococcus multilocularis cyclins 0.0253 0.1051 0.2834
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0079 0.0272 0.1201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0036 0.0159
Toxoplasma gondii hypothetical protein 0.0061 0.0192 0.0928
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0248 0.1224
Schistosoma mansoni hypothetical protein 0.0034 0.0072 0.0214
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0002 0.0006
Entamoeba histolytica hypothetical protein 0.0079 0.0272 0.1514
Trichomonas vaginalis cyclin B, putative 0.0061 0.0192 0.0848
Mycobacterium tuberculosis Conserved protein 0.0074 0.0248 0.1224
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.008 0.0273
Brugia malayi beta-lactamase 0.0074 0.0248 0.0246
Trichomonas vaginalis cyclins, putative 0.0377 0.1604 0.7097
Schistosoma mansoni smad 0.0042 0.0106 0.0314
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0192 0.0848
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0136 0.0727
Echinococcus multilocularis peregrin 0.003 0.0054 0.0145
Trichomonas vaginalis cyclin D, putative 0.0253 0.1051 0.465
Schistosoma mansoni Cyclin fold protein 0.0061 0.0192 0.0569
Echinococcus multilocularis aurora kinase A 0.0346 0.1467 0.3955
Loa Loa (eye worm) hypothetical protein 0.0377 0.1604 0.1603
Entamoeba histolytica PH domain containing protein kinase, putative 0.0026 0.0034 0.0133
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0026 0.0034 0.0133
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0346 0.1467 0.8459
Echinococcus granulosus cyclin dependent kinase 5 0.0405 0.1732 0.5147
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0377 0.1604 0.9258
Echinococcus granulosus dna polymerase eta 0.0021 0.0011 0.0033
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0088 0.0312 0.031
Echinococcus multilocularis cyclin dependent kinase 1 0.0405 0.1732 0.467
Loa Loa (eye worm) hypothetical protein 0.0074 0.0248 0.0246
Loa Loa (eye worm) nuclear factor I 0.0023 0.0022 0.002
Echinococcus multilocularis cyclin t1 0.0061 0.0192 0.0517
Schistosoma mansoni chromobox protein 0.0072 0.0242 0.072
Trichomonas vaginalis AGC family protein kinase 0.0346 0.1467 0.6488
Brugia malayi hypothetical protein 0.0061 0.0192 0.019
Brugia malayi Cyclin, N-terminal domain containing protein 0.0377 0.1604 0.1603
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0061 0.0192 0.0928
Schistosoma mansoni regulator of G protein signaling 0.0079 0.0272 0.0807
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0026 0.0034 0.015
Echinococcus multilocularis cyclin B3 1 0.0253 0.1051 0.2834
Trypanosoma cruzi cdc2-related kinase 1 0.0405 0.1732 1
Giardia lamblia Cyclin fold protein 1, putative 0.0061 0.0192 0.1049
Brugia malayi Heterochromatin protein 1 0.0072 0.0242 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.008 0.0355
Schistosoma mansoni z-protein (S1r protein) 0.0079 0.0272 0.0807
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0248 0.0737
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0136 0.0727
Loa Loa (eye worm) RGS-3 protein 0.0079 0.0272 0.027
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.01 0.0433
Trypanosoma cruzi Protein kinase B 0.0026 0.0034 0.0133
Echinococcus multilocularis Smad4 0.0042 0.0106 0.0285
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0213 0.0575
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0106 0.0314
Schistosoma mansoni smad1 5 8 and 0.0042 0.0106 0.0314
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0011 0.0427
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0078 0.0266 0.0792
Echinococcus granulosus Cyclin L1 0.0061 0.0192 0.0569
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0009
Onchocerca volvulus Protein CNPPD1 homolog 0.0061 0.0192 0.084
Leishmania major folate/biopterin transporter, putative 0.0026 0.0034 0.0133
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0771 0.3365 0.3364
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0192 0.0848
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0006 0.0027
Echinococcus granulosus smad 0.0042 0.0106 0.0314
Schistosoma mansoni cyclin G2 0.0061 0.0192 0.0569
Entamoeba histolytica protein kinase domain containing protein 0.0346 0.1467 0.8459
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0405 0.1732 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0018 0.0055
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0061 0.0192 0.1052
Echinococcus granulosus cyclin y 0.0061 0.0192 0.0569
Trypanosoma brucei cdc2-related kinase 1 0.0405 0.1732 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0048 0.0214
Schistosoma mansoni g1/s-specific cyclin C 0.0061 0.0192 0.0569
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0061 0.0192 0.0569
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0248 0.1096
Trichomonas vaginalis cyclin B3, putative 0.0061 0.0192 0.0848
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0176 0.0174
Echinococcus multilocularis rac serine:threonine kinase 0.0026 0.0034 0.0092
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0534 0.1586
Entamoeba histolytica hypothetical protein 0.0061 0.0192 0.1049
Mycobacterium ulcerans lipase LipD 0.0074 0.0248 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0534 0.1586
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0061 0.0192 0.0569
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0042 0.1688
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0014
Leishmania major protein kinase, putative 0.0026 0.0034 0.0133
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0346 0.1467 0.4359
Echinococcus multilocularis G1:S specific cyclin D1 0.0061 0.0192 0.0517
Brugia malayi PXA domain containing protein 0.0079 0.0272 0.027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0011 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.008 0.0355
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0248 0.1096
Brugia malayi Cyclin, N-terminal domain containing protein 0.0253 0.1051 0.1049
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0026 0.0034 0.0133
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0011 0.0033
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0088 0.0312 0.031
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0131 0.0702
Loa Loa (eye worm) hypothetical protein 0.0032 0.0061 0.0059
Loa Loa (eye worm) cyclin domain-containing protein 0.0061 0.0192 0.019
Schistosoma mansoni hypothetical protein 0.0061 0.0192 0.0569
Loa Loa (eye worm) glutathione reductase 0.0048 0.0131 0.013
Echinococcus granulosus intermediate filament protein 0.0058 0.0176 0.0524
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0405 0.1999
Echinococcus multilocularis dna polymerase eta 0.0021 0.0011 0.003
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0692 0.3011 0.8121
Giardia lamblia Hypothetical protein 0.0061 0.0192 0.1049
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0009
Trichomonas vaginalis cyclin B3, putative 0.0253 0.1051 0.465
Schistosoma mansoni cyclin B 0.0377 0.1604 0.4767
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0014
Schistosoma mansoni eyes absent homolog 0.0092 0.0328 0.0975
Brugia malayi Cyclin, N-terminal domain containing protein 0.0377 0.1604 0.1603
Leishmania major hypothetical protein, conserved 0.005 0.0142 0.0759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0036 0.0158
Loa Loa (eye worm) AUR protein kinase 0.0346 0.1467 0.1465
Trypanosoma cruzi NIMA-related kinase, putative 0.0026 0.0034 0.0133
Loa Loa (eye worm) hypothetical protein 0.0066 0.0213 0.0211
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0114 0.0502
Plasmodium vivax SET domain protein, putative 0.0066 0.0213 0.1178
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0026 0.0034 0.0133
Trichomonas vaginalis AGC family protein kinase 0.0346 0.1467 0.6488
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0248 0.0246
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0176 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0092 0.0405
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.0431 0.128
Echinococcus granulosus lamin dm0 0.0058 0.0176 0.0524
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0534 0.1439
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0213 0.1057
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0136 0.0739
Schistosoma mansoni Smad4 0.0019 0.0002 0.0006
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0248 0.0246
Brugia malayi cell division control protein 2 homolog 0.0405 0.1732 0.173
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0056 0.0055
Loa Loa (eye worm) transcription factor SMAD2 0.0615 0.2668 0.2666
Trichomonas vaginalis cyclin B, putative 0.0253 0.1051 0.465
Echinococcus granulosus regulator of G protein signaling 3 0.0079 0.0272 0.0807
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0079 0.0272 0.0807
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0156 0.0462
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0026 0.0034 0.0146
Trypanosoma cruzi cdc2-related kinase 3 0.0405 0.1732 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0061 0.0192 0.019
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0253 0.1051 0.2834
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0248 0.1224
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0082 0.0245
Schistosoma mansoni serine/threonine protein kinase 0.0771 0.3365 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0054 0.0145
Entamoeba histolytica protein kinase, putative 0.0026 0.0034 0.0133
Schistosoma mansoni serine/threonine-protein kinase 0.0026 0.0034 0.0101
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0213 0.0634
Loa Loa (eye worm) hypothetical protein 0.0092 0.0328 0.0326
Echinococcus multilocularis cyclins 0.0253 0.1051 0.2834
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Echinococcus multilocularis cyclin dependent kinase 5 0.0405 0.1732 0.467
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0248 0.1224
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0213 0.0634
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0142 0.0759
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.046 0.1976 0.1975
Entamoeba histolytica PH domain containing protein kinase, putative 0.0026 0.0034 0.0133
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0043 0.0127
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0011 0.0014
Echinococcus granulosus axis inhibition protein axin 0.0079 0.0272 0.0807
Trichomonas vaginalis CMGC family protein kinase 0.0405 0.1732 0.7662
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0272 0.1201
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Trichomonas vaginalis cyclins, putative 0.0253 0.1051 0.465
Brugia malayi MH2 domain containing protein 0.0042 0.0106 0.0104
Schistosoma mansoni axis inhibition protein axin 0.0079 0.0272 0.0807
Onchocerca volvulus 0.0061 0.0192 0.084
Echinococcus multilocularis cyclin y 0.0061 0.0192 0.0517
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0131 0.0391
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0136 0.0134
Echinococcus granulosus cyclin k 0.0061 0.0192 0.0569
Schistosoma mansoni serine/threonine protein kinase 0.0346 0.1467 0.4359
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0176 0.0174
Trichomonas vaginalis cyclin B, putative 0.0377 0.1604 0.7097
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0014
Entamoeba histolytica protein kinase, putative 0.0026 0.0034 0.0133
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0405 0.1732 1
Echinococcus granulosus cyclin B 0.0377 0.1604 0.4767
Onchocerca volvulus 0.0074 0.0248 0.1089
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0143 0.0141
Entamoeba histolytica protein kinase, putative 0.0026 0.0034 0.0133
Plasmodium vivax cyclin homologue, putative 0.0061 0.0192 0.1052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0136 0.0602
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0079 0.0272 0.027
Echinococcus multilocularis cyclin dependent kinase 0.0405 0.1732 0.467
Schistosoma mansoni cyclins 0.0253 0.1051 0.3123
Schistosoma mansoni hypothetical protein 0.0022 0.0018 0.0055
Echinococcus multilocularis cyclin k 0.0061 0.0192 0.0517
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0405 0.1732 0.5147
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0272 0.1201
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0061 0.0192 0.019
Loa Loa (eye worm) cyclin domain-containing protein 0.0253 0.1051 0.1049
Loa Loa (eye worm) hypothetical protein 0.0079 0.0272 0.027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0534 0.1586
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Loa Loa (eye worm) cyclin domain-containing protein 0.0061 0.0192 0.019
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Echinococcus granulosus chromobox protein 1 0.0072 0.0242 0.072
Echinococcus granulosus cyclins 0.0253 0.1051 0.3123
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0011 0.0014
Loa Loa (eye worm) PXA domain-containing protein 0.0079 0.0272 0.027
Echinococcus granulosus cyclin G2 0.0061 0.0192 0.0569
Brugia malayi hypothetical protein 0.0092 0.0328 0.0326
Onchocerca volvulus 0.0524 0.226 1
Schistosoma mansoni axis inhibition protein axin 0.0079 0.0272 0.0807
Trypanosoma cruzi cyclin, putative 0.0377 0.1604 0.9258
Trypanosoma cruzi CYC2-like cyclin, putative 0.0377 0.1604 0.9258
Entamoeba histolytica hypothetical protein 0.0115 0.0431 0.2439
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0082 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.006 0.0264
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0026 0.0034 0.0133
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0011 0.0014
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Brugia malayi serine/threonine kinase 12 0.0346 0.1467 0.1465
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0061 0.0192 0.1061
Plasmodium falciparum phd finger protein, putative 0.003 0.0054 0.0251
Schistosoma mansoni hypothetical protein 0.003 0.0054 0.016
Entamoeba histolytica hypothetical protein 0.0079 0.0272 0.1514
Brugia malayi PHD-finger family protein 0.003 0.0054 0.0052
Trichomonas vaginalis cyclins, putative 0.0061 0.0192 0.0848
Loa Loa (eye worm) hypothetical protein 0.0397 0.1692 0.169
Loa Loa (eye worm) AUR protein kinase 0.0346 0.1467 0.1465
Loa Loa (eye worm) hypothetical protein 0.0052 0.0151 0.0149
Loa Loa (eye worm) hypothetical protein 0.0053 0.0156 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0136 0.0602
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0011 0.0446
Echinococcus granulosus regulator of G protein signaling 7 0.0079 0.0272 0.0807
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0405 0.1732 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0106 0.0285
Schistosoma mansoni regulator of G protein signaling 0.0079 0.0272 0.0807
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0042 0.1688
Trichomonas vaginalis cyclins, putative 0.0185 0.0745 0.3295
Trichomonas vaginalis cyclins, putative 0.0377 0.1604 0.7097
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.004
Trypanosoma brucei unspecified product 0.0021 0.0011 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.01 0.0441
Schistosoma mansoni Smad4 0.0042 0.0106 0.0314
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0405 0.1999
Echinococcus multilocularis cyclins 0.0253 0.1051 0.2834
Toxoplasma gondii aurora kinase 0.0346 0.1467 0.8438
Echinococcus multilocularis chromobox protein 1 0.0072 0.0242 0.0653
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0248 0.1378
Trichomonas vaginalis cyclin B, putative 0.0377 0.1604 0.7097
Brugia malayi hypothetical protein 0.0032 0.0063 0.0061
Echinococcus granulosus cyclin A3 4 0.0061 0.0192 0.0569
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0092 0.0482
Schistosoma mansoni regulator of G protein signaling 0.0079 0.0272 0.0807
Schistosoma mansoni hypothetical protein 0.0708 0.3084 0.9164
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0082 0.008
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0114 0.0502
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0534 0.1586
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0107 0.0318
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0192 0.1052
Trichomonas vaginalis cyclins, putative 0.0377 0.1604 0.7097
Echinococcus granulosus cyclins 0.0253 0.1051 0.3123
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0106 0.0314
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0002 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0615 0.2668 0.2666
Echinococcus granulosus expressed protein 0.0079 0.0272 0.0807
Loa Loa (eye worm) hypothetical protein 0.0074 0.0248 0.0246
Brugia malayi Protein kinase domain containing protein 0.0405 0.1732 0.173
Toxoplasma gondii cyclin 4, putative 0.0061 0.0192 0.0928
Schistosoma mansoni lamin 0.0058 0.0176 0.0524
Echinococcus granulosus geminin 0.0708 0.3084 0.9164
Schistosoma mansoni smad1 5 8 and 0.0042 0.0106 0.0314
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0248 0.1376
Entamoeba histolytica hypothetical protein 0.0115 0.0431 0.2439
Brugia malayi serine/threonine protein kinase 6 0.0346 0.1467 0.1465
Trichomonas vaginalis cyclin A, putative 0.0377 0.1604 0.7097
Giardia lamblia Kinase, CMGC CDK 0.0405 0.1732 1
Echinococcus multilocularis lamin 0.0058 0.0176 0.0476
Echinococcus granulosus tumor protein p63 0.0362 0.154 0.4575
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0346 0.1467 0.8459
Echinococcus granulosus regulator of G protein signaling 7 0.0079 0.0272 0.0807
Trypanosoma brucei trypanothione reductase 0.0048 0.0131 0.0712
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0014
Giardia lamblia Kinase, CMGC CDK 0.0405 0.1732 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0106 0.0104
Entamoeba histolytica protein kinase, putative 0.0026 0.0034 0.0133
Echinococcus granulosus G protein coupled receptor kinase 1 0.0692 0.3011 0.895
Trichomonas vaginalis AGC family protein kinase 0.0346 0.1467 0.6488
Echinococcus multilocularis tumor protein p63 0.0362 0.154 0.4152
Echinococcus multilocularis axis inhibition protein axin 0.0079 0.0272 0.0732
Trypanosoma brucei cyclin 9 0.0061 0.0192 0.1061
Entamoeba histolytica PH domain containing protein kinase, putative 0.0026 0.0034 0.0133
Leishmania major cyclin 0.0377 0.1604 0.9258
Loa Loa (eye worm) hypothetical protein 0.0079 0.0272 0.027
Brugia malayi hypothetical protein 0.0079 0.0272 0.027
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0002 0.0005
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0248 0.0668
Entamoeba histolytica cyclin, putative 0.0253 0.1051 0.6043
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0011 0.0033
Brugia malayi MH2 domain containing protein 0.0042 0.0106 0.0104
Loa Loa (eye worm) hypothetical protein 0.005 0.0142 0.014
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0036 0.0158
Echinococcus multilocularis cyclin 0.0061 0.0192 0.0517
Loa Loa (eye worm) hypothetical protein 0.0377 0.1604 0.1603
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0042 0.0179
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0009
Echinococcus multilocularis cyclin y 0.0061 0.0192 0.0517
Giardia lamblia GTOR 0.0049 0.0136 0.0727
Echinococcus multilocularis axis inhibition protein axin 0.0079 0.0272 0.0732
Echinococcus granulosus cyclins 0.0253 0.1051 0.3123
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0041
Echinococcus multilocularis musashi 0.0058 0.0176 0.0476
Trichomonas vaginalis cyclin B, putative 0.0377 0.1604 0.7097
Brugia malayi jmjC domain containing protein 0.0037 0.0082 0.008
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0092 0.0469
Trichomonas vaginalis cyclin B, putative 0.0377 0.1604 0.7097
Schistosoma mansoni cyclin d 0.0061 0.0192 0.0569
Brugia malayi Pre-SET motif family protein 0.0066 0.0213 0.0211
Brugia malayi hypothetical protein 0.0079 0.0272 0.027
Leishmania major protein kinase, putative 0.0026 0.0034 0.0133
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0405 0.1999
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0136 0.0405
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0043 0.0115
Echinococcus granulosus aurora kinase A 0.0346 0.1467 0.4359
Entamoeba histolytica cyclin, putative 0.0377 0.1604 0.9258
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0042 0.1688
Brugia malayi Cyclin, N-terminal domain containing protein 0.0061 0.0192 0.019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0034 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0104 0.0461
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0142 0.0762
Leishmania major hypothetical protein, conserved 0.0074 0.0248 0.1376
Leishmania major mitotic cyclin, putative 0.0061 0.0192 0.1049
Brugia malayi Bromodomain containing protein 0.003 0.0054 0.0052
Echinococcus multilocularis cyclins 0.0253 0.1051 0.2834
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0011 0.0009
Echinococcus granulosus cyclins 0.0253 0.1051 0.3123
Echinococcus granulosus cyclins 0.0061 0.0192 0.0569
Brugia malayi glutathione reductase 0.0048 0.0131 0.013
Entamoeba histolytica hypothetical protein 0.0115 0.0431 0.2439
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0248 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0042 0.1688
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0142 0.0762
Trichomonas vaginalis cyclin D, putative 0.0061 0.0192 0.0848
Schistosoma mansoni hypothetical protein 0.0115 0.0431 0.128
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.002
Loa Loa (eye worm) hypothetical protein 0.0061 0.0192 0.019
Brugia malayi Thioredoxin reductase 0.0048 0.0131 0.013
Brugia malayi MH1 domain containing protein 0.0042 0.0106 0.0104
Echinococcus granulosus serine/threonine protein kinase 0.0026 0.0034 0.0101
Plasmodium falciparum protein kinase 5 0.0405 0.1732 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0048 0.0214
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0136 0.0367
Trypanosoma brucei mitotic cyclin 6 0.0377 0.1604 0.9259
Echinococcus granulosus cyclin dependent kinase 0.0405 0.1732 0.5147
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0346 0.1467 0.8459
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0014
Brugia malayi A-kinase anchor protein 10, precursor 0.0079 0.0272 0.027
Brugia malayi Cyclin, N-terminal domain containing protein 0.0061 0.0192 0.019
Loa Loa (eye worm) hypothetical protein 0.0041 0.01 0.0098
Loa Loa (eye worm) beta-lactamase 0.0074 0.0248 0.0246
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0107 0.0288
Brugia malayi jmjC domain containing protein 0.0099 0.0362 0.036
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0405 0.1732 0.173
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0362 0.1076
Schistosoma mansoni chromobox protein 0.0072 0.0242 0.072
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0143 0.0141
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0079 0.0272 0.0807
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.01 0.0441
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0026 0.0034 0.0146
Trypanosoma cruzi cyclin 6, putative 0.0377 0.1604 0.9258
Echinococcus multilocularis regulator of G protein signaling 7 0.0079 0.0272 0.0732
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0346 0.1467 0.8459
Trichomonas vaginalis cyclin A, putative 0.0061 0.0192 0.0848
Brugia malayi Regulator of G protein signaling domain containing protein 0.0079 0.0272 0.027
Schistosoma mansoni smad 0.0019 0.0002 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0272 0.1201
Onchocerca volvulus Cyclin L homolog 0.0061 0.0192 0.084
Echinococcus multilocularis cyclin G2 0.0061 0.0192 0.0517
Onchocerca volvulus Alhambra homolog 0.003 0.0054 0.0229
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0248 0.1224
Trichomonas vaginalis conserved hypothetical protein 0.0253 0.1051 0.465
Trichomonas vaginalis cyclins, putative 0.0377 0.1604 0.7097
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0026 0.0034 0.0136
Echinococcus granulosus regulator of G protein signaling 3 0.0079 0.0272 0.0807
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0248 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0011 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0036 0.0158
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0042 0.0179
Trichomonas vaginalis CMGC family protein kinase 0.0405 0.1732 0.7662
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0082 0.0245
Echinococcus granulosus cyclin dependent kinase 1 0.0405 0.1732 0.5147
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0271 0.0805
Trypanosoma cruzi aurora B kinase, putative 0.0346 0.1467 0.8459
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0011 0.003

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Toxicity in albino Mus musculus (mouse) assessed as change in temperature at extremities at 150 to 900 mg/kg, ip measured within 24 hr ChEMBL. No reference
Activity (ADMET) Toxicity in albino Mus musculus (mouse) assessed as change in skin color at 150 to 900 mg/kg, ip measured within 24 hr ChEMBL. No reference
Activity (ADMET) Toxicity in albino Mus musculus (mouse) assessed as increase in heart rate at 150 to 900 mg/kg, ip measured within 1 to 2 hr ChEMBL. No reference
Activity (ADMET) Toxicity in albino Mus musculus (mouse) assessed as change in toes color at 150 to 900 mg/kg, ip measured within 24 hr ChEMBL. No reference
Activity (ADMET) Toxicity in albino Mus musculus (mouse) assessed as tremor in hind limbs at 150 to 900 mg/kg, ip measured within 24 hr ChEMBL. No reference
Activity (ADMET) Toxicity in albino Mus musculus (mouse) assessed as rapid respiration at 150 to 900 mg/kg, ip measured within 1 to 2 hr ChEMBL. No reference
Activity (ADMET) Toxicity in albino Mus musculus (mouse) assessed as change in eye color at 150 to 900 mg/kg, ip measured within 24 hr ChEMBL. No reference
LD50 (ADMET) = 495 mg kg-1 Toxicity in ip dosed albino Mus musculus (mouse) assessed as mortality measured within 24 hr ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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