Detailed information for compound 1807168

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 540.654 | Formula: C35H32N4O2
  • H donors: 1 H acceptors: 4 LogP: 5.72 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#Cc1cccc(c1)CN1C(CCc2ccccc2)C(O)C(N(C1=O)Cc1cccc(c1)C#N)Cc1ccccc1
  • InChi: 1S/C35H32N4O2/c36-22-28-13-7-15-30(19-28)24-38-32(18-17-26-9-3-1-4-10-26)34(40)33(21-27-11-5-2-6-12-27)39(35(38)41)25-31-16-8-14-29(20-31)23-37/h1-16,19-20,32-34,40H,17-18,21,24-25H2
  • InChiKey: MHLVDKMRDDJFBG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Protease Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Protease   99 aa 102 aa 32.4 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Protease   99 aa 102 aa 32.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0063 0.0169
Onchocerca volvulus 0.0094 0.0267 0.0727
Entamoeba histolytica hypothetical protein 0.0036 0.0074 0.0199
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0283 0.0772
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0016 0.0029
Echinococcus multilocularis thymidylate kinase 0.1122 0.3644 0.9324
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.001 0.0027
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0065 0.017 0.0462
Trypanosoma brucei thymidylate kinase, putative 0.1122 0.3644 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0074 0.0177
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0055 0.0137 0.0371
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0065 0.017 0.0466
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0002 0.0005
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0073 0.0198 0.0539
Schistosoma mansoni hypothetical protein 0.0168 0.051 0.0506
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0108 0.0292
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0071 0.019 0.052
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.03 0.0942 0.2581
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0065 0.017 0.0466
Mycobacterium ulcerans hypothetical protein 0.0035 0.0074 0.0177
Brugia malayi beta-lactamase family protein 0.0035 0.0074 0.0199
Leishmania major oligopeptidase b 0.0071 0.019 0.0516
Giardia lamblia Thymus-specific serine protease precursor 0.0065 0.017 0.044
Schistosoma mansoni hypothetical protein 0.0813 0.2629 0.2626
Toxoplasma gondii hypothetical protein 0.0071 0.019 0.0494
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0071 0.019 0.0494
Schistosoma mansoni hypothetical protein 0.0031 0.006 0.0056
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0065 0.017 0.0466
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0074 0.0203
Trichomonas vaginalis thymidylate kinase, putative 0.1122 0.3644 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0074 0.0203
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0002 0.0005
Schistosoma mansoni thymidylate kinase 0.1122 0.3644 0.3642
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0078 0.021
Entamoeba histolytica hypothetical protein 0.0073 0.0198 0.0539
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0016 0.001 0.0015
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0065 0.017 0.0166
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0199
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0069
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0074 0.0177
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0076 0.0204
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0078 0.021
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0121 0.0356 0.0901
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.006 0.0161
Schistosoma mansoni hypothetical protein 0.0031 0.006 0.0056
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0492 0.125
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0078 0.0214
Loa Loa (eye worm) hypothetical protein 0.0071 0.019 0.0516
Brugia malayi prolyl oligopeptidase family protein 0.0071 0.019 0.0516
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.001 0.0006
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0074 0.0199
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0121 0.0356 0.0976
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.0325 0.0866
Loa Loa (eye worm) deoxynucleoside kinase 0.0073 0.0198 0.0539
Brugia malayi Latrophilin receptor protein 2 0.0031 0.006 0.0161
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0121 0.0356 0.0901
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0022 0.0047
Onchocerca volvulus Huntingtin homolog 0.0122 0.0359 0.0982
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0065 0.017 0.0462
Trypanosoma cruzi oligopeptidase b 0.0071 0.019 0.0516
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0097 0.0268
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0065 0.017 0.0466
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0074 0.0177
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0016 0.001 0.0022
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0074 0.018
Echinococcus multilocularis GPCR, family 2 0.0031 0.006 0.0144
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0065 0.017 0.044
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0016 0.0029
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0078 0.0188
Schistosoma mansoni hypothetical protein 0.0036 0.0074 0.007
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0027 0.0046
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0086 0.0209
Schistosoma mansoni hypothetical protein 0.0068 0.018 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0002 0.0002
Trichomonas vaginalis esterase, putative 0.0035 0.0074 0.0203
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0164 0.0446
Onchocerca volvulus 0.0065 0.017 0.0462
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0065 0.017 0.0466
Brugia malayi prolyl oligopeptidase family protein 0.0891 0.2886 0.7917
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.0555 0.141
Schistosoma mansoni ap endonuclease 0.0037 0.0078 0.0074
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0327 0.1031 0.2631
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0022 0.0057
Echinococcus granulosus prolyl endopeptidase 0.0071 0.019 0.0475
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0027 0.0058
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0182 0.0555 0.1518
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0034 0.0088
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.1202 0.3908 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.0492 0.1346
Schistosoma mansoni hypothetical protein 0.0168 0.051 0.0506
Loa Loa (eye worm) hypothetical protein 0.0121 0.0356 0.0972
Brugia malayi Deoxynucleoside kinase family protein 0.0073 0.0198 0.0539
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0074 0.0177
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0055 0.0137 0.034
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0164 0.016
Echinococcus multilocularis geminin 0.0168 0.051 0.1295
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0074 0.007
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0121 0.0356 0.0976
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0002 0.0005
Plasmodium falciparum importin beta, putative 0.0029 0.0051 0.0114
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.03 0.0942 0.2581
Echinococcus multilocularis neuropeptide receptor A26 0.0462 0.1475 0.3767
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0076 0.0209
Echinococcus granulosus Dipeptidyl peptidase 9 0.03 0.0942 0.2402
Schistosoma mansoni thymidine kinase 0.0327 0.1031 0.1027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0199
Loa Loa (eye worm) hypothetical protein 0.0229 0.071 0.1944
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.001 0.0027
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0065 0.017 0.0466
Entamoeba histolytica hypothetical protein 0.0073 0.0198 0.0539
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0022 0.0061
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0108 0.0292
Loa Loa (eye worm) transcriptional regulator 0.0016 0.001 0.0022
Trypanosoma brucei prolyl oligopeptidase, putative 0.0071 0.019 0.0516
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0022 0.0061
Entamoeba histolytica hypothetical protein 0.0023 0.0034 0.0088
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0355 0.0351
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0055 0.0137 0.0371
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0164 0.0446
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0076 0.0204
Giardia lamblia CDC8 0.1122 0.3644 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0069
Leishmania major DNA polymerase eta, putative 0.0032 0.0063 0.0169
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.001 0.0022
Trypanosoma brucei unspecified product 0.0014 0.0002 0.0002
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.0434 0.11
Echinococcus multilocularis dna polymerase eta 0.0046 0.0108 0.0266
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.019 0.0516
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0065 0.017 0.0466
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0078 0.019
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0065 0.017 0.0466
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0057
Trypanosoma cruzi thymidylate kinase, putative 0.1122 0.3644 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0046
Echinococcus multilocularis acylamino acid releasing enzyme 0.0071 0.019 0.0475
Leishmania major GTP-binding protein, putative 0.0021 0.0027 0.0069
Echinococcus granulosus microtubule associated protein 2 0.0689 0.2222 0.568
Schistosoma mansoni cpg binding protein 0.0057 0.0145 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0055 0.0137 0.0133
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0198 0.0543
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0164 0.0409
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0137 0.0371
Entamoeba histolytica hypothetical protein 0.0073 0.0198 0.0539
Loa Loa (eye worm) hypothetical protein 0.0122 0.0359 0.0982
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0022 0.0034
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0051 0.0121
Schistosoma mansoni hypothetical protein 0.0305 0.0961 0.0957
Loa Loa (eye worm) hypothetical protein 0.0065 0.017 0.0462
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.001 0.0022
Plasmodium vivax importin-beta 2, putative 0.0029 0.0051 0.0114
Trypanosoma brucei prolyl endopeptidase 0.0071 0.019 0.0516
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.03 0.0942 0.2581
Plasmodium vivax thymidylate kinase, putative 0.1122 0.3644 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0097 0.0241
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.0073 0.0198 0.0497
Echinococcus multilocularis neuropeptide s receptor 0.0462 0.1475 0.3767
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.006 0.0144
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.001 0.0022
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0016 0.001 0.0015
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0074 0.0199
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.0137
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0016 0.001 0.0022
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0076 0.0204
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0016 0.001 0.0015
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0016 0.0038
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0055 0.0137 0.0371
Brugia malayi CXXC zinc finger family protein 0.0057 0.0145 0.0394
Leishmania major sir2-family protein-like protein 0.0016 0.001 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.017 0.0466
Echinococcus granulosus importin subunit beta 1 0.0029 0.0051 0.0121
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0071 0.019 0.0323
Plasmodium falciparum peptidase, putative 0.0071 0.019 0.0494
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0182 0.0555 0.1518
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.0492 0.125
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.0434 0.043
Brugia malayi RNA, U transporter 1 0.0081 0.0225 0.0612
Schistosoma mansoni hypothetical protein 0.0031 0.006 0.0056
Echinococcus granulosus geminin 0.0168 0.051 0.1295
Entamoeba histolytica hypothetical protein 0.0073 0.0198 0.0539
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0074 0.0203
Trichomonas vaginalis ran, putative 0.0021 0.0027 0.0073
Giardia lamblia Deoxynucleoside kinase 0.0073 0.0198 0.0518
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0057
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0065 0.017 0.0466
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0065 0.017 0.0466
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0078 0.0214
Loa Loa (eye worm) acetyltransferase 0.0145 0.0434 0.1186
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0055 0.0137 0.0371
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0086 0.0231
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.001 0.0022
Schistosoma mansoni hypothetical protein 0.0031 0.006 0.0056
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0283 0.0772
Entamoeba histolytica hypothetical protein 0.0073 0.0198 0.0539
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0097 0.0268
Schistosoma mansoni alpha glucosidase 0.0036 0.0076 0.0072
Schistosoma mansoni ran 0.0021 0.0027 0.0023
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.001 0.0006
Entamoeba histolytica prolyl oligopeptidase family protein 0.0071 0.019 0.0516
Echinococcus granulosus cpg binding protein 0.006 0.0156 0.0389
Echinococcus multilocularis cpg binding protein 0.006 0.0156 0.0389
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0022 0.0057
Echinococcus granulosus neuropeptide receptor A26 0.0462 0.1475 0.3767
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0164 0.016
Schistosoma mansoni alpha-glucosidase 0.014 0.0418 0.0414
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0071 0.019 0.0516
Giardia lamblia Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative 0.0073 0.0198 0.0518
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0078 0.021
Onchocerca volvulus Prolyl endopeptidase homolog 0.0071 0.019 0.0516
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0556 0.1783 0.178
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0016 0.001 0.0015
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0073 0.0198 0.0539
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.03 0.0942 0.2581
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0074 0.0203
Onchocerca volvulus 0.0035 0.0074 0.0199
Brugia malayi beta-lactamase family protein 0.0035 0.0074 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0198 0.0543
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.006 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0057
Loa Loa (eye worm) hypothetical protein 0.0065 0.017 0.0462
Giardia lamblia Hypothetical protein 0.0073 0.0198 0.0518
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0071 0.019 0.0186
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.1202 0.3908 0.3906
Onchocerca volvulus Huntingtin homolog 0.0122 0.0359 0.0982
Loa Loa (eye worm) hypothetical protein 0.0065 0.017 0.0462
Echinococcus multilocularis transfer RNA-Ile 0.0327 0.1031 0.2631
Mycobacterium ulcerans lipase LipD 0.0035 0.0074 0.0177
Entamoeba histolytica Thymidylate kinase, putative 0.1122 0.3644 1
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0891 0.2886 0.7381
Brugia malayi RNA binding protein 0.0063 0.0164 0.0446
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0057
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0097 0.0241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0555 0.0551
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.03 0.0942 0.2565
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0078 0.021
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.0434 0.1186
Mycobacterium tuberculosis Conserved protein 0.0035 0.0074 0.0177
Trypanosoma brucei unspecified product 0.0014 0.0002 0.0002
Schistosoma mansoni ran 0.0021 0.0027 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.0555 0.141
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0074 0.0177
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0057
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0078 0.0188
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0002 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0137 0.0375
Brugia malayi thymidylate kinase 0.1122 0.3644 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.019 0.0516
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0016 0.001 0.0022
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0283 0.0772
Entamoeba histolytica hypothetical protein 0.0073 0.0198 0.0539
Loa Loa (eye worm) hypothetical protein 0.0105 0.0303 0.0828
Giardia lamblia Alanyl dipeptidyl peptidase 0.0071 0.019 0.0494
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0071 0.019 0.0516
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0074 0.007
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0051 0.0137
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0078 0.021
Brugia malayi Serine carboxypeptidase S28 family protein 0.0065 0.017 0.0462
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.03 0.0942 0.0938
Echinococcus multilocularis microtubule associated protein 2 0.0689 0.2222 0.568
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0074 0.0177
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0071 0.019 0.0516
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0055 0.0137 0.034
Plasmodium falciparum thymidylate kinase 0.1122 0.3644 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0121 0.0356 0.0352
Echinococcus multilocularis thymidine kinase 0.0327 0.1031 0.2631
Leishmania major thymidylate kinase-like protein 0.1122 0.3644 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.0703 0.1906
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0076 0.0209
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0016 0.001 0.0022
Brugia malayi Serine protease Z688.6 precursor 0.0065 0.017 0.0462
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0022 0.0034
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0076 0.0209
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0071 0.019 0.0516
Echinococcus multilocularis snurportin 1 0.0305 0.0961 0.2451
Trypanosoma brucei glucosidase, putative 0.0036 0.0076 0.0204
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.001 0.0027
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0074 0.0177
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0065 0.017 0.0466
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0065 0.017 0.0424
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.0555 0.141
Echinococcus granulosus dna polymerase eta 0.0046 0.0108 0.0266
Echinococcus multilocularis prolyl endopeptidase 0.0071 0.019 0.0475
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0022 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0164 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0198 0.0543
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0065 0.017 0.0466
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0074 0.018
Brugia malayi prolyl oligopeptidase family protein 0.03 0.0942 0.2581
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0022 0.0047
Giardia lamblia Serine peptidase, putative 0.0065 0.017 0.044
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0051 0.0114
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.018 0.0489
Loa Loa (eye worm) hypothetical protein 0.0068 0.018 0.0489
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.1122 0.3644 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0016 0.001 0.0015
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0022 0.0018
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0022 0.0057
Schistosoma mansoni hypothetical protein 0.1122 0.3644 0.3642
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.03 0.0942 0.2581
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.1122 0.3644 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0076 0.0209
Entamoeba histolytica DNA repair and recombination protein, putative 0.0055 0.0137 0.0371
Mycobacterium tuberculosis Conserved protein 0.0035 0.0074 0.0177
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0065 0.017 0.0462
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0199
Trypanosoma brucei oligopeptidase b 0.0071 0.019 0.0516
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0002 0.0005
Trichomonas vaginalis thymidylate kinase, putative 0.1122 0.3644 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.0492 0.125
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0057
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0097 0.0241
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0002 0.0002
Brugia malayi NAD-dependent deacetylase SIRT1 0.0121 0.0356 0.0972
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.001 0.0027
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0078 0.0188
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.0492 0.1346
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0034 0.0092
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0076 0.0209
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0074 0.0177
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0074 0.0199
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0076 0.0182
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0016 0.001 0.0022
Echinococcus multilocularis dna polymerase kappa 0.002 0.0022 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0057
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0801 0.2591 0.6626
Leishmania major DNA polymerase kappa, putative 0.002 0.0022 0.0057
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.001 0.0027
Loa Loa (eye worm) transcriptional regulator 0.0016 0.001 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0076 0.0209
Trypanosoma cruzi thymidylate kinase, putative 0.1122 0.3644 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0022 0.0034
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0073 0.0198 0.0539
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0076 0.0184
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0891 0.2886 0.2883
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0055 0.0137 0.0371
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.1122 0.3644 1
Schistosoma mansoni thymidylate kinase 0.1122 0.3644 0.3642
Brugia malayi N-terminal motif family protein 0.0178 0.0542 0.1484
Brugia malayi hypothetical protein 0.0229 0.071 0.1944
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0016 0.001 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0074 0.0199
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0199
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0076 0.0204
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0071 0.019 0.0186
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0002 0.0005
Leishmania major DNA polymerase eta, putative 0.0046 0.0108 0.0292
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0078 0.019
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.001 0.0027
Entamoeba histolytica prolyl oligopeptidase family protein 0.0071 0.019 0.0516
Brugia malayi hypothetical protein 0.0122 0.0359 0.0982
Trypanosoma brucei unspecified product 0.002 0.0022 0.0057
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0071 0.019 0.0516
Loa Loa (eye worm) hypothetical protein 0.0031 0.006 0.0161
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0073 0.0198 0.0539
Chlamydia trachomatis thymidylate kinase 0.1122 0.3644 0.5
Mycobacterium ulcerans beta-lactamase 0.0035 0.0074 0.0177
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0002 0.0005
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.001 0.0027
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0078 0.021
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0034 0.0092
Giardia lamblia Hypothetical protein 0.0073 0.0198 0.0518
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0164 0.0446
Echinococcus granulosus dna polymerase kappa 0.002 0.0022 0.0047
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0069
Toxoplasma gondii thymidylate kinase 0.1122 0.3644 1
Entamoeba histolytica hypothetical protein, conserved 0.0071 0.019 0.0516
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0071 0.019 0.0516
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0071 0.019 0.0494
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0121 0.0356 0.0976
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0002 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.019 0.052
Schistosoma mansoni cpg binding protein 0.006 0.0156 0.0152
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0071 0.019 0.0516
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0069
Trypanosoma brucei thymidylate kinase, putative 0.1122 0.3644 1
Onchocerca volvulus 0.0035 0.0074 0.0199
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.0542 0.1484
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.001 0.0006
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0074 0.0179
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0164 0.016
Echinococcus granulosus neuropeptide s receptor 0.0462 0.1475 0.3767
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0891 0.2886 0.7381
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0076 0.0204
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0022 0.0057
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0016 0.001 0.0022
Brugia malayi hypothetical protein 0.0036 0.0074 0.0199
Brugia malayi beta-lactamase 0.0035 0.0074 0.0199
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.0961 0.2633
Entamoeba histolytica hypothetical protein 0.0036 0.0074 0.0199
Echinococcus granulosus thymidine kinase 0.0327 0.1031 0.2631
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0015 0.0036
Treponema pallidum thymidylate kinase (tmk) 0.1122 0.3644 1
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0055 0.0137 0.0371
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.001 0.0006
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0071 0.019 0.0186
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.0555 0.141
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0016 0.001 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0057
Mycobacterium ulcerans thymidylate kinase 0.1122 0.3644 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.0359 0.0982
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0022 0.0057
Trypanosoma cruzi oligopeptidase b 0.0071 0.019 0.0516
Loa Loa (eye worm) thymidylate kinase 0.1122 0.3644 1
Onchocerca volvulus 0.0035 0.0074 0.0199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0555 0.0551
Brugia malayi prolyl oligopeptidase family protein 0.0071 0.019 0.0516
Loa Loa (eye worm) hypothetical protein 0.0065 0.017 0.0462
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.006 0.0161
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0071 0.019 0.0516
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0073 0.0198 0.0194
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0074 0.0177
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0076 0.0209
Loa Loa (eye worm) sirtuin 4 0.0016 0.001 0.0022
Loa Loa (eye worm) prolyl oligopeptidase 0.0071 0.019 0.0516
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0074 0.0203
Loa Loa (eye worm) hypothetical protein 0.0071 0.019 0.0516
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0065 0.017 0.0466
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0164 0.016
Echinococcus granulosus GPCR family 2 0.0031 0.006 0.0144
Entamoeba histolytica hypothetical protein 0.0073 0.0198 0.0539
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0074 0.007
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0074 0.0177
Echinococcus multilocularis thymidine kinase 0.0327 0.1031 0.2631
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0121 0.0356 0.0952
Toxoplasma gondii ABC1 family protein 0.0035 0.0074 0.0177
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.0073 0.0198 0.0497
Loa Loa (eye worm) hypothetical protein 0.0099 0.0283 0.0772
Loa Loa (eye worm) beta-lactamase 0.0035 0.0074 0.0199
Onchocerca volvulus Putative thymidylate kinase 0.1122 0.3644 1
Schistosoma mansoni DNA polymerase eta 0.0046 0.0108 0.0104
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0074 0.0179
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0076 0.0204
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.001 0.0006
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0071 0.019 0.052
Schistosoma mansoni ap endonuclease 0.0037 0.0078 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0198 0.0543
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0071 0.019 0.0494
Leishmania major hypothetical protein, conserved 0.0035 0.0074 0.0199
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0065 0.017 0.0462
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0074 0.0199
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0063 0.0147
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.044 0.1404 0.3851
Echinococcus granulosus thymidine kinase 0.0327 0.1031 0.2631
Toxoplasma gondii exonuclease III APE 0.0037 0.0078 0.0188
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0016 0.001 0.0022
Entamoeba histolytica hypothetical protein 0.0073 0.0198 0.0539
Loa Loa (eye worm) transcriptional regulator 0.0016 0.001 0.0022
Onchocerca volvulus 0.0057 0.0145 0.0394
Loa Loa (eye worm) RNA binding protein 0.0063 0.0164 0.0446
Loa Loa (eye worm) prolyl oligopeptidase 0.0891 0.2886 0.7917
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0078 0.0188
Echinococcus granulosus thymidylate kinase 0.1122 0.3644 0.9324
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0076 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.017 0.0466
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0555 0.0551
Schistosoma mansoni microtubule-associated protein tau 0.0689 0.2222 0.2218
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0086 0.0209
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0076 0.0184
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0034 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0198 0.0543
Brugia malayi TAR-binding protein 0.0063 0.0164 0.0446
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0051 0.0137
Entamoeba histolytica Ran family GTPase 0.0021 0.0027 0.0069
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.042 0.1066
Toxoplasma gondii prolyl endopeptidase 0.0071 0.019 0.0494
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0027 0.0046
Mycobacterium tuberculosis Probable peptidase 0.0071 0.019 0.0494
Leishmania major hypothetical protein, conserved 0.044 0.1404 0.3851
Echinococcus granulosus snurportin 1 0.0305 0.0961 0.2451
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0065 0.017 0.0466
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0891 0.2886 0.7917
Loa Loa (eye worm) hypothetical protein 0.0178 0.0542 0.1484
Giardia lamblia Alanyl dipeptidyl peptidase 0.0071 0.019 0.0494
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0016 0.001 0.0022
Entamoeba histolytica hypothetical protein 0.0036 0.0074 0.0199
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.001 0.0006
Echinococcus multilocularis dnaJ subfamily B 0.0813 0.2629 0.6724
Trypanosoma brucei SIR2-like protein 4, putative 0.0016 0.001 0.0022
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0108 0.0292
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0199
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0046
Entamoeba histolytica prolyl oligopeptidase family protein 0.0071 0.019 0.0516
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0065 0.017 0.0462
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0022 0.0057
Echinococcus granulosus dnaJ subfamily B 0.0813 0.2629 0.6724
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0027 0.0058
Trypanosoma cruzi prolyl endopeptidase 0.0071 0.019 0.0516
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0065 0.017 0.0424
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.019 0.0516
Echinococcus granulosus chromatin regulatory protein sir2 0.0016 0.001 0.0015
Schistosoma mansoni alpha-glucosidase 0.014 0.0418 0.0414
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0078 0.021
Echinococcus granulosus acylamino acid releasing enzyme 0.0071 0.019 0.0475
Plasmodium vivax hypothetical protein, conserved 0.0071 0.019 0.0494
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0057
Schistosoma mansoni importin beta-1 0.0029 0.0051 0.0047
Echinococcus multilocularis Dipeptidyl peptidase 9 0.03 0.0942 0.2402
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0074 0.0177
Echinococcus multilocularis chromatin regulatory protein sir2 0.0016 0.001 0.0015
Schistosoma mansoni cpg binding protein 0.006 0.0156 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0076 0.0204
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0199
Brugia malayi prolyl oligopeptidase family protein 0.0071 0.019 0.0516
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0022 0.0034
Leishmania major importin beta-1 subunit, putative 0.0023 0.0034 0.0088
Giardia lamblia Rrm3p helicase 0.0055 0.0137 0.0349
Brugia malayi Importin beta-1 subunit 0.0029 0.0051 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0057
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.1202 0.3908 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0065 0.017 0.0466
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0076 0.0209
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0071 0.019 0.0186
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.006 0.0144
Loa Loa (eye worm) hypothetical protein 0.0046 0.0108 0.0292
Brugia malayi Serine protease Z688.6 precursor 0.0065 0.017 0.0462
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.044 0.1404 0.3851
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.006 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0022 0.0057
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0016 0.001 0.0022
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0145 0.0394
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0055 0.0137 0.0371
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0121 0.0356 0.0976
Leishmania major silent information regulator 2, putative 0.0016 0.001 0.0022
Entamoeba histolytica hypothetical protein 0.0073 0.0198 0.0539
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0078 0.0188
Entamoeba histolytica hypothetical protein 0.0036 0.0074 0.0199
Echinococcus granulosus tar DNA binding protein 0.0063 0.0164 0.0409
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0097 0.0239
Giardia lamblia DINP protein human, muc B family 0.002 0.0022 0.0034
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0016 0.001 0.0022
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0065 0.017 0.0462

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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