Detailed information for compound 1812607

Basic information

Technical information
  • TDR Targets ID: 1812607
  • Name: 1,3-thiazole-5-carbaldehyde
  • MW: 113.138 | Formula: C4H3NOS
  • H donors: 0 H acceptors: 2 LogP: 0.75 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=Cc1cncs1
  • InChi: 1S/C4H3NOS/c6-2-4-1-5-3-7-4/h1-3H
  • InChiKey: ZXRLWHGLEJGMNO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Thiazole-5-carbaldehyde
  • 5-Thiazolecarboxaldehyde
  • 1003-32-3
  • 658103_ALDRICH
  • ZINC02577851
  • T2161M500

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Agaricus bisporus Tyrosinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0186 1
Brugia malayi RNA recognition motif domain containing protein 0.0059 0.0125 0.0419
Loa Loa (eye worm) hypothetical protein 0.0063 0.0139 0.0469
Schistosoma mansoni hypothetical protein 0.0024 0.0013 0.0021
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0186 0.0282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0349 1
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0777 0.2392 1
Onchocerca volvulus 0.0034 0.0047 0.0393
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0027 0.0084
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0105 0.4992
Onchocerca volvulus 0.0111 0.029 0.2572
Echinococcus multilocularis short transient receptor potential channel 6 0.0124 0.033 0.0327
Entamoeba histolytica recQ family helicase, putative 0.0043 0.0075 0.078
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0071 0.0162 0.853
Loa Loa (eye worm) latrophilin receptor protein 2 0.0128 0.0344 0.1175
Treponema pallidum heat shock protein 90 0.0025 0.0018 0.0963
Schistosoma mansoni glutaminase 0.0284 0.0834 0.1288
Trypanosoma brucei heat shock protein, putative 0.0031 0.0038 0.0335
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0047 0.0432
Brugia malayi Latrophilin receptor protein 2 0.0128 0.0344 0.1175
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0059 0.1958
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0124 0.0409
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0027 0.0084
Echinococcus multilocularis lamin 0.0028 0.0027 0.0024
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0044 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0785 0.9399
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0186 1
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0524 0.6229
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0071 0.0162 0.4351
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0349 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0105 0.2624
Loa Loa (eye worm) hypothetical protein 0.0071 0.0162 0.0548
Echinococcus granulosus bloom syndrome protein 0.0063 0.0136 0.0206
Echinococcus granulosus heat shock protein 90 0.0031 0.0038 0.0054
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0071 0.0162 0.0555
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0043 0.0075 0.1473
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0047 0.0432
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0114 0.0383
Schistosoma mansoni endoplasmin 0.0031 0.0038 0.0059
Schistosoma mansoni inositol monophosphatase 0.0115 0.0303 0.0468
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0273 0.0421
Echinococcus granulosus GPCR family 2 0.0128 0.0344 0.0527
Brugia malayi MH2 domain containing protein 0.0489 0.1481 0.5089
Echinococcus granulosus survival motor neuron protein 1 0.0941 0.2908 0.4485
Schistosoma mansoni hypothetical protein 0.0039 0.0063 0.0097
Brugia malayi hypothetical protein 0.0374 0.1118 0.3839
Schistosoma mansoni transient receptor potential channel 0.0187 0.053 0.0818
Toxoplasma gondii hypothetical protein 0.0071 0.0162 0.535
Trichomonas vaginalis glutaminase, putative 0.0284 0.0834 1
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0494 0.5866
Trichomonas vaginalis sucrase-isomaltase, putative 0.0075 0.0176 0.2001
Schistosoma mansoni hypothetical protein 0.0039 0.0063 0.0097
Loa Loa (eye worm) TAR-binding protein 0.0059 0.0125 0.0419
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0096 0.0244 0.0376
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0101 0.0349
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0192 0.0545 0.1865
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0494 0.5866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0349 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0349 1
Plasmodium vivax heat shock protein 86, putative 0.0031 0.0038 0.0863
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Schistosoma mansoni hypothetical protein 0.0128 0.0344 0.0531
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0125 0.0192
Echinococcus granulosus Smad4 0.0033 0.0044 0.0064
Brugia malayi Smad1 0.0033 0.0044 0.0142
Brugia malayi Cathepsin L-like precursor 0.0034 0.0047 0.0151
Echinococcus multilocularis tar DNA binding protein 0.0059 0.0125 0.0122
Toxoplasma gondii heat shock protein 90, putative 0.0031 0.0038 0.1256
Entamoeba histolytica hypothetical protein 0.0113 0.0294 0.3073
Brugia malayi Glycosyl hydrolases family 31 protein 0.0338 0.1006 0.3454
Brugia malayi follicle stimulating hormone receptor 0.025 0.0728 0.2496
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0047 0.0151
Entamoeba histolytica hypothetical protein 0.0113 0.0294 0.3073
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0027 0.0196
Echinococcus granulosus endoplasmin 0.0025 0.0018 0.0023
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.003 0.0033 0.0193
Onchocerca volvulus 0.0028 0.0027 0.0219
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0115 0.0303 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0003 0.0005
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0038 0.0335
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0106 0.0273 0.7691
Echinococcus multilocularis geminin 0.1031 0.3193 0.3191
Brugia malayi Calcitonin receptor-like protein seb-1 0.0406 0.1219 0.4188
Onchocerca volvulus 0.0111 0.029 0.2572
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0071 0.0162 0.4187
Onchocerca volvulus 0.0111 0.029 0.2572
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Plasmodium vivax vivapain-2 0.0034 0.0047 0.14
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0115 0.0303 0.3165
Echinococcus granulosus inositol monophosphatase 1 0.0115 0.0303 0.0463
Schistosoma mansoni tyrosinase precursor 0.0111 0.029 0.0447
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.0728 0.2496
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0047 0.0151
Brugia malayi Isocitrate dehydrogenase 0.003 0.0033 0.0105
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0011 0.0028
Schistosoma mansoni coup transcription factor 0.002 0.0003 0.0005
Schistosoma mansoni heat shock protein 0.0031 0.0038 0.0059
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.0027 0.0218
Echinococcus multilocularis smad 0.0033 0.0044 0.0041
Entamoeba histolytica hypothetical protein 0.0113 0.0294 0.3073
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0047 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.007 0.072
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0047 0.0393
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0303 0.8601
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0038 0.0215
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0785 0.9399
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.003 0.0033 0.0052
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.007 0.1584
Echinococcus multilocularis Smad4 0.0033 0.0044 0.0041
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.003 0.0033 0.0047
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0003 0.0005
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.007 0.0067
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0103 0.0265 0.0951
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0071 0.0162 0.0555
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0124 0.3201
Brugia malayi DnaJ domain containing protein 0.0064 0.014 0.0471
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0047 0.0432
Schistosoma mansoni alpha-glucosidase 0.0291 0.0858 0.1324
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0128 0.0344 0.0341
Trypanosoma brucei protein kinase, putative 0.0106 0.0273 0.7624
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0047 0.0393
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0111 0.029 0.0987
Schistosoma mansoni cellular tumor antigen P53 0.0103 0.0263 0.0406
Trypanosoma cruzi major cysteine proteinase, putative 0.0102 0.0262 0.7351
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0105 0.4992
Leishmania major cathepsin L-like protease 0.0034 0.0047 0.087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0047 0.0432
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0239 0.2496
Leishmania major hypothetical protein, conserved 0.0071 0.0162 0.4351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0047 0.0432
Echinococcus granulosus intermediate filament protein 0.0028 0.0027 0.0038
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0003 0.0005
Trichomonas vaginalis inositol monophosphatase, putative 0.0115 0.0303 0.3545
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0125 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0785 0.9399
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.007 0.0232
Echinococcus multilocularis inositol monophosphatase 1 0.0115 0.0303 0.03
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0785 0.9399
Schistosoma mansoni alpha glucosidase 0.0075 0.0176 0.0271
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0018 0.0023
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0106 0.0273 0.7691
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0075 0.0176 0.5804
Brugia malayi Transient-receptor-potential like protein 0.007 0.0159 0.0536
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0124 0.0191
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0071 0.0162 0.0555
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0047 0.0393
Schistosoma mansoni endoplasmin 0.0031 0.0038 0.0059
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0059 0.1935
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0115 0.0303 0.1098
Brugia malayi Glycosyl hydrolases family 31 protein 0.0075 0.0176 0.0595
Loa Loa (eye worm) MH2 domain-containing protein 0.0489 0.1481 0.5089
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0127 0.0191
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0071 0.0162 0.0607
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0027 0.0282
Leishmania major cathepsin L-like protease 0.0034 0.0047 0.087
Loa Loa (eye worm) hypothetical protein 0.005 0.0097 0.0323
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Leishmania major cathepsin L-like protease 0.0034 0.0047 0.087
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0024 0.1297
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0013 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0047 0.0432
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0047 0.14
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0043 0.0075 0.1714
Echinococcus granulosus heat shock protein 0.0031 0.0038 0.0054
Leishmania major hypothetical protein, conserved 0.0071 0.0162 0.4351
Loa Loa (eye worm) hypothetical protein 0.0128 0.0344 0.1175
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Brugia malayi MH2 domain containing protein 0.0033 0.0044 0.0142
Loa Loa (eye worm) hypothetical protein 0.0277 0.0814 0.2793
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0303 0.8601
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.003 0.0033 0.0578
Echinococcus multilocularis neutral alpha glucosidase AB 0.0075 0.0176 0.0173
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0003 0.0005
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0127 0.0124
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0027 0.0282
Loa Loa (eye worm) hypothetical protein 0.007 0.0159 0.0536
Onchocerca volvulus 0.0111 0.029 0.2572
Loa Loa (eye worm) ctsf protein 0.0034 0.0047 0.0151
Brugia malayi Cathepsin L-like precursor 0.0023 0.0011 0.0028
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0186 0.0647
Toxoplasma gondii cathepsin CPL 0.0034 0.0047 0.1543
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0071 0.0162 0.0555
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0039 0.0062 0.2321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0047 0.0432
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0125 0.0192
Brugia malayi glutaminase DH11.1 0.0284 0.0834 0.2862
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0186 0.0647
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0124 0.0409
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0092 0.0229 0.239
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0003 0.0005
Onchocerca volvulus 0.0103 0.0263 0.2332
Onchocerca volvulus Putative fad oxidoreductase 0.0071 0.0162 0.1427
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0071 0.0162 0.0555
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0071 0.0162 0.0548
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0084
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0038 0.0059 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0047 0.0432
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.007 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0047 0.0432
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0018 0.0082
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.0176 0.2001
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.007 0.1339
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.0349 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0187 0.053 0.0527
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Schistosoma mansoni inositol monophosphatase 0.0115 0.0303 0.0468
Trichomonas vaginalis DNA helicase recq, putative 0.0063 0.0136 0.1521
Echinococcus granulosus expressed conserved protein 0.0089 0.0221 0.0336
Giardia lamblia Kinase, CMGC MAPK 0.0106 0.0273 0.2714
Loa Loa (eye worm) RNA binding protein 0.0059 0.0125 0.0419
Loa Loa (eye worm) hypothetical protein 0.0941 0.2908 1
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0071 0.0162 0.0555
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0106 0.0273 0.7691
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0125 0.0419
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0071 0.0162 0.4187
Trypanosoma brucei heat shock protein, putative 0.0031 0.0038 0.0335
Echinococcus granulosus lamin 0.0028 0.0027 0.0038
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0024 0.0024
Giardia lamblia Sgs1 DNA helicase, putative 0.0038 0.0059 0.0433
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0127 0.042
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Echinococcus granulosus cathepsin l1 0.0023 0.0011 0.0013
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0047 0.14
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0038 0.0335
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0071 0.0162 0.1427
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0027 0.0196
Schistosoma mansoni hypothetical protein 0.0113 0.0294 0.0454
Onchocerca volvulus 0.0034 0.0047 0.0393
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.003 0.0033 0.0066
Echinococcus granulosus short transient receptor potential channel 6 0.0124 0.033 0.0505
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0011 0.0017
Brugia malayi Cathepsin L-like precursor 0.0034 0.0047 0.0151
Loa Loa (eye worm) tyrosinase 1 0.0111 0.029 0.0987
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0047 0.0044
Echinococcus multilocularis lysosomal alpha glucosidase 0.0338 0.1006 0.1004
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0303 0.8561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0349 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0047 0.0432
Trypanosoma cruzi cruzipain precursor, putative 0.013 0.0349 1
Schistosoma mansoni hypothetical protein 0.0039 0.0063 0.0097
Echinococcus multilocularis heat shock protein 90 0.0025 0.0018 0.0015
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0127 0.0196
Echinococcus granulosus short transient receptor potential channel 6 0.0124 0.033 0.0505
Echinococcus granulosus neutral alpha glucosidase AB 0.0075 0.0176 0.0267
Schistosoma mansoni Smad4 0.0033 0.0044 0.0068
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0115 0.0303 0.3545
Loa Loa (eye worm) hypothetical protein 0.0118 0.031 0.1057
Onchocerca volvulus 0.0034 0.0047 0.0393
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0186 0.6135
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.0349 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0186 1
Echinococcus granulosus neuropeptide s receptor 0.187 0.5842 0.9015
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.003 0.0033 0.0469
Brugia malayi CHE-14 protein 0.0041 0.0068 0.0223
Trypanosoma brucei heat shock protein, putative 0.0031 0.0038 0.0335
Echinococcus multilocularis neuropeptide receptor A26 0.187 0.5842 0.584
Loa Loa (eye worm) hypothetical protein 0.0044 0.0078 0.0257
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0127 0.042
Schistosoma mansoni hypothetical protein 0.0192 0.0545 0.084
Brugia malayi Endoplasmin precursor 0.0031 0.0038 0.0121
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0047 0.14
Echinococcus granulosus geminin 0.1031 0.3193 0.4925
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0071 0.0162 0.025
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0494 0.5866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0349 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0059 0.1935
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.003 0.0033 0.0578
Loa Loa (eye worm) RecQ helicase 0.0063 0.0136 0.0459
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0128 0.0344 0.1175
Schistosoma mansoni hypothetical protein 0.0128 0.0344 0.0531
Brugia malayi cDNA sequence BC016226 0.0071 0.0162 0.0548
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0124 0.0447
Loa Loa (eye worm) fibroinase 0.0034 0.0047 0.0151
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.007 0.0104
Schistosoma mansoni transient receptor potential channel 4 0.0187 0.053 0.0818
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0176 0.2001
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.007 0.1584
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.007 0.0735
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0494 0.5866
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0075 0.0176 0.0595
Loa Loa (eye worm) hypothetical protein 0.0053 0.0105 0.0351
Brugia malayi RNA binding protein 0.0059 0.0125 0.0419
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.007 0.0104
Schistosoma mansoni intermediate filament proteins 0.0028 0.0027 0.0042
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0027 0.0285
Loa Loa (eye worm) glutaminase 0.0284 0.0834 0.2862
Leishmania major cathepsin L-like protease 0.013 0.0349 1
Brugia malayi hypothetical protein 0.0053 0.0105 0.0351
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0349 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0106 0.0273 0.0417
Onchocerca volvulus 0.0034 0.0047 0.0393
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0027 0.0196
Loa Loa (eye worm) ShTK domain-containing protein 0.0111 0.029 0.0987
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0106 0.0273 0.7691
Echinococcus granulosus neuropeptide receptor A26 0.187 0.5842 0.9015
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0125 0.0192
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0059 0.0192
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.007 0.0067
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0111 0.029 0.0987
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Echinococcus multilocularis tumor protein p63 0.0701 0.2152 0.215
Loa Loa (eye worm) hypothetical protein 0.0111 0.029 0.0987
Trypanosoma brucei heat shock protein, putative 0.0031 0.0038 0.0335
Brugia malayi isocitrate dehydrogenase 0.003 0.0033 0.0105
Echinococcus multilocularis expressed conserved protein 0.0089 0.0221 0.0218
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0044 0.0064
Schistosoma mansoni smad1 5 8 and 0.0033 0.0044 0.0068
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0128 0.0344 0.0527
Trichomonas vaginalis protein kinase inhibitor, putative 0.0064 0.014 0.1561
Echinococcus multilocularis lamin dm0 0.0028 0.0027 0.0024
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0043 0.0075 0.1714
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0125 0.0188
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0003 0.0005
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.0294 0.0454
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Echinococcus multilocularis mitogen activated protein kinase 0.0106 0.0273 0.027
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0071 0.0162 0.4187
Schistosoma mansoni survival motor neuron protein 0.0192 0.0545 0.084
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0003 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0124 0.0191
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0071 0.0162 0.0246
Echinococcus granulosus lysosomal alpha glucosidase 0.0338 0.1006 0.1549
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0273 0.3179
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0059 0.0125 0.0419
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0027 0.0196
Leishmania major cathepsin L-like protease 0.0034 0.0047 0.087
Trypanosoma brucei heat shock protein, putative 0.0031 0.0038 0.0335
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0028
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0125 0.0188
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0494 0.5866
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0105 0.4992
Brugia malayi MH1 domain containing protein 0.0033 0.0044 0.0142
Loa Loa (eye worm) hypothetical protein 0.0406 0.1219 0.4188
Trypanosoma brucei heat shock protein, putative 0.0031 0.0038 0.0335
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0125 0.0122
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0044 0.0041
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0068 0.01
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0027 0.0196
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0124 0.0121
Leishmania major hypothetical protein, conserved 0.0053 0.0105 0.2624
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0494 0.5866
Leishmania major cathepsin L-like protease 0.013 0.0349 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0106 0.0273 0.9004
Trichomonas vaginalis DNA helicase recq1, putative 0.0063 0.0136 0.1521
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0338 0.1006 0.3454
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0027 0.0196
Schistosoma mansoni DNA helicase recq1 0.0038 0.0059 0.009
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0111 0.029 0.0987
Echinococcus multilocularis heat shock protein 0.0031 0.0038 0.0035
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0038 0.0327
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0105 0.241
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0071 0.0162 0.1535
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0127 0.0459
Echinococcus multilocularis protein dispatched 1 0.0047 0.0086 0.0083
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0124 0.0187
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.0294 0.045
Brugia malayi Cathepsin L-like precursor 0.0034 0.0047 0.0151
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0038 0.0608
Echinococcus granulosus heat shock protein 90 0.0025 0.0018 0.0023
Loa Loa (eye worm) heat shock protein 90 0.0031 0.0038 0.0121
Brugia malayi hypothetical protein 0.0034 0.0046 0.0149
Brugia malayi hypothetical protein 0.0941 0.2908 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.007 0.0109
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0018 0.0082
Loa Loa (eye worm) transcription factor SMAD2 0.0489 0.1481 0.5089
Echinococcus multilocularis endoplasmin 0.0025 0.0018 0.0015
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0038 0.0398
Brugia malayi hypothetical protein 0.0113 0.0294 0.1003
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0124 0.4093
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0047 0.0488
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0003 0.0005
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0047 0.0044
Schistosoma mansoni fad oxidoreductase 0.0071 0.0162 0.025
Schistosoma mansoni transient receptor potential channel 0.0124 0.033 0.0509
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0028
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0079
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0013 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0047 0.0432
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0038 0.0059 0.0086
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0071 0.0162 0.0159
Echinococcus granulosus microtubule associated protein 2 0.2072 0.648 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0128 0.0344 0.0341
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0323 0.0957 1
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0349 1
Echinococcus multilocularis neuropeptide s receptor 0.187 0.5842 0.584
Toxoplasma gondii hypothetical protein 0.0027 0.0024 0.0795
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0125 0.0192
Echinococcus granulosus lamin dm0 0.0028 0.0027 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0047 0.0432
Echinococcus multilocularis short transient receptor potential channel 6 0.0124 0.033 0.0327
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0349 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0033 0.0031
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0071 0.0162 0.4187
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0018 0.0082
Mycobacterium ulcerans glutaminase 0.0284 0.0834 0.3144
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0176 0.2001
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.003 0.0033 0.0469
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0059 0.0192
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0047 0.0488
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0071 0.0162 0.4351
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0106 0.0273 0.7624
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0044 0.0142
Brugia malayi Cathepsin L-like precursor 0.0034 0.0047 0.0151
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0303 0.8601
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0176 0.2001
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0273 0.3179
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0027 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0047 0.0432
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0071 0.0162 0.0548
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0071 0.0162 0.4351
Schistosoma mansoni microtubule-associated protein tau 0.2072 0.648 1
Schistosoma mansoni fad oxidoreductase 0.0071 0.0162 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0047 0.0432
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0273 0.3179
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0119 0.0314 0.8926
Schistosoma mansoni DNA helicase recq5 0.0038 0.0059 0.009
Echinococcus granulosus cathepsin l1 0.0034 0.0047 0.0068
Echinococcus granulosus smad 0.0033 0.0044 0.0064
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0186 1
Trichomonas vaginalis DNA helicase recq, putative 0.0043 0.0075 0.0772
Loa Loa (eye worm) inositol-1 0.0115 0.0303 0.1033
Loa Loa (eye worm) Smad1 0.0033 0.0044 0.0142
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0106 0.0273 0.0929
Giardia lamblia DNA repair protein RAD52 0.0323 0.0957 1
Onchocerca volvulus 0.0028 0.0027 0.0219
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0186 0.5892
Brugia malayi heat shock protein 90 0.0031 0.0038 0.0121
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.007 0.072
Echinococcus multilocularis dnaJ subfamily C 6 0.0064 0.014 0.0137
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0176 0.4766
Leishmania major alpha glucosidase II subunit, putative 0.0075 0.0176 0.4766
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0071 0.0162 0.4187
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0038 0.0059 0.2133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0047 0.0432
Schistosoma mansoni hypothetical protein 0.1031 0.3193 0.4928
Schistosoma mansoni transient receptor potential channel 0.0124 0.033 0.0509
Brugia malayi ShTK domain containing protein 0.0111 0.029 0.0987
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0103 0.0265 0.104
Brugia malayi Common central domain of tyrosinase family protein 0.0111 0.029 0.0987
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0047 0.0068
Schistosoma mansoni smad1 5 8 and 0.0033 0.0044 0.0068
Trypanosoma brucei isocitrate dehydrogenase, putative 0.003 0.0033 0.0193
Schistosoma mansoni smad1 5 8 and 0.0033 0.0044 0.0068
Loa Loa (eye worm) hypothetical protein 0.0103 0.0263 0.0895
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0105 0.3461
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0268 0.0785 0.2692
Schistosoma mansoni heat shock protein 0.0031 0.0038 0.0059
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0068 0.01
Schistosoma mansoni hypothetical protein 0.0039 0.0063 0.0097
Brugia malayi Cathepsin L-like precursor 0.0034 0.0047 0.0151
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.0294 0.0291
Schistosoma mansoni hypothetical protein 0.1031 0.3193 0.4928
Schistosoma mansoni hypothetical protein 0.0128 0.0344 0.0531
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0848 0.2615 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0038 0.0059 0.0192
Schistosoma mansoni alpha-glucosidase 0.0291 0.0858 0.1324
Entamoeba histolytica hypothetical protein 0.0092 0.0229 0.239
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0047 0.0432
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0003 0.0005
Echinococcus multilocularis heat shock protein 90 0.0031 0.0038 0.0035
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0047 0.087
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0071 0.0162 0.1693
Leishmania major glycosyl hydrolase-like protein 0.0028 0.0027 0.0282
Brugia malayi RE18450p 0.0071 0.0162 0.0548
Toxoplasma gondii heat shock protein HSP90 0.0031 0.0038 0.1256
Echinococcus multilocularis lysosomal alpha glucosidase 0.0338 0.1006 0.1004
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0027 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0047 0.0432
Loa Loa (eye worm) DnaJ domain-containing protein 0.0064 0.014 0.0471
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0047 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.0273 0.3179
Brugia malayi Cathepsin L-like precursor 0.0034 0.0047 0.0151
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0071 0.0162 0.4351
Leishmania major cathepsin L-like protease 0.0034 0.0047 0.087
Schistosoma mansoni blooms syndrome DNA helicase 0.0043 0.0075 0.0116
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0071 0.0162 0.4351
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0047 0.0432
Echinococcus multilocularis GPCR, family 2 0.0128 0.0344 0.0341
Echinococcus multilocularis cysteine protease 0.0034 0.0047 0.0044
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0038 0.0608
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0101 0.0151
Schistosoma mansoni patched 1 0.0041 0.0068 0.0105
Plasmodium vivax endoplasmin, putative 0.0031 0.0038 0.0863
Brugia malayi intermediate filament protein 0.0028 0.0027 0.0084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0047 0.0432
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0027 0.0084
Onchocerca volvulus 0.0023 0.0011 0.0074
Loa Loa (eye worm) endoplasmin 0.0031 0.0038 0.0121
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.003 0.0033 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0047 0.0432
Echinococcus granulosus tar DNA binding protein 0.0059 0.0125 0.0188
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0068 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0047 0.0432
Toxoplasma gondii isocitrate dehydrogenase 0.003 0.0033 0.1104
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0038 0.0059 0.0056
Echinococcus granulosus mitogen activated protein kinase 0.0106 0.0273 0.0417
Entamoeba histolytica hypothetical protein 0.0113 0.0294 0.3073
Loa Loa (eye worm) hypothetical protein 0.0374 0.1118 0.3839
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.003 0.0033 0.0469
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.0494 0.4404
Trypanosoma brucei heat shock protein, putative 0.0031 0.0038 0.0335
Loa Loa (eye worm) hypothetical protein 0.0071 0.0162 0.0548
Brugia malayi jmjC domain containing protein 0.0059 0.0125 0.0419
Onchocerca volvulus 0.0192 0.0545 0.4856
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0003 0.0005
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0186 0.0287
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.007 0.0559
Schistosoma mansoni hypothetical protein 0.0277 0.0814 0.1257
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0042 0.007 0.0232
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.007 0.1584
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0239 0.0364
Schistosoma mansoni d-amino acid oxidase 0.0848 0.2615 0.4036
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0115 0.0303 0.3545
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0047 0.0432
Trypanosoma cruzi Heat shock protein 83, putative 0.0031 0.0038 0.0608
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0047 0.0432
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0125 0.0192
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.007 0.0104
Loa Loa (eye worm) hypothetical protein 0.0038 0.0059 0.0192
Schistosoma mansoni lamin 0.0028 0.0027 0.0042
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0848 0.2615 1
Entamoeba histolytica cysteine protease, putative 0.0034 0.0047 0.0488
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0106 0.0273 0.7691
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0027 0.0084
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0084
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0071 0.0162 0.853
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0075 0.0176 0.2001
Onchocerca volvulus Huntingtin homolog 0.0374 0.1118 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0044 0.0142
Echinococcus multilocularis microtubule associated protein 2 0.2072 0.648 0.6479
Schistosoma mansoni lamin 0.0028 0.0027 0.0042
Echinococcus multilocularis isocitrate dehydrogenase 0.003 0.0033 0.0031
Echinococcus multilocularis transient receptor potential ion channel A 0.0181 0.051 0.0507
Loa Loa (eye worm) hypothetical protein 0.0187 0.053 0.1814
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0128 0.0344 0.0527
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0047 0.0432
Onchocerca volvulus 0.0034 0.0047 0.0393
Trypanosoma brucei glucosidase, putative 0.0075 0.0176 0.4614
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0101 0.0319
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0186 0.6135
Brugia malayi Probable ClpP-like protease 0.0078 0.0186 0.063
Onchocerca volvulus 0.0034 0.0047 0.0393
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0033 0.0031
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0186 0.0647
Onchocerca volvulus 0.0034 0.0047 0.0393
Loa Loa (eye worm) hypothetical protein 0.0374 0.1118 0.3839
Onchocerca volvulus Huntingtin homolog 0.0374 0.1118 1
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0047 0.0072
Brugia malayi Inositol-1 0.0115 0.0303 0.1033
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0047 0.0068
Loa Loa (eye worm) hypothetical protein 0.0034 0.0047 0.0151
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0047 0.0044
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0071 0.0162 0.4351
Onchocerca volvulus 0.0196 0.0556 0.4962
Plasmodium falciparum heat shock protein 90 0.0031 0.0038 0.0863
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0105 0.2624
Brugia malayi MH2 domain containing protein 0.0033 0.0044 0.0142
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0115 0.0303 1
Brugia malayi Cathepsin L-like precursor 0.0023 0.0011 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0176 0.4766
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0038 0.0608
Echinococcus multilocularis TRP (transient receptor potential) channel 0.007 0.0159 0.0156
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0494 0.5866
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0406 0.1219 0.4188
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0071 0.0162 0.0548
Loa Loa (eye worm) hypothetical protein 0.0095 0.0239 0.0812
Leishmania major heat shock protein 83-1 0.0031 0.0038 0.0608
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0038 0.0398
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.0176 0.1837
Brugia malayi Bloom's syndrome protein homolog 0.0063 0.0136 0.0459
Brugia malayi TAR-binding protein 0.0059 0.0125 0.0419
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0239 0.0236
Loa Loa (eye worm) hypothetical protein 0.0111 0.029 0.0987
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0127 0.329
Schistosoma mansoni thyroid hormone receptor 0.002 0.0003 0.0005
Toxoplasma gondii isocitrate dehydrogenase 0.003 0.0033 0.1104
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0111 0.029 0.0987
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0044 0.0064
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0239 0.0812
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0268 0.0785 0.2692
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0071 0.0162 0.1693
Echinococcus multilocularis mitogen activated protein kinase 3 0.0106 0.0273 0.027
Trypanosoma brucei Heat shock protein 83, putative 0.0031 0.0038 0.0335
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0038 0.0059 0.0086
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0071 0.0162 0.1427
Echinococcus granulosus dnaJ subfamily C 6 0.0064 0.014 0.0211
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0785 0.9399
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0125 0.0122
Loa Loa (eye worm) hypothetical protein 0.0071 0.0162 0.0548
Echinococcus granulosus tumor protein p63 0.0701 0.2152 0.3319
Echinococcus multilocularis bloom syndrome protein 0.0063 0.0136 0.0133
Loa Loa (eye worm) glutaminase 2 0.0284 0.0834 0.2862
Echinococcus multilocularis survival motor neuron protein 1 0.0941 0.2908 0.2906
Loa Loa (eye worm) hypothetical protein 0.0078 0.0186 0.063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0349 1
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0071 0.0162 0.4351
Loa Loa (eye worm) cysteine protease 0.0034 0.0047 0.0151
Loa Loa (eye worm) ShTK domain-containing protein 0.0111 0.029 0.0987
Brugia malayi latrophilin 2 splice variant baaae 0.0277 0.0814 0.2793
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.0349 1
Brugia malayi jmjC domain containing protein 0.0059 0.0125 0.0419
Schistosoma mansoni thyroid hormone receptor 0.002 0.0003 0.0005
Trichomonas vaginalis maltase-glucoamylase, putative 0.0075 0.0176 0.2001
Schistosoma mansoni smad 0.0033 0.0044 0.0068
Schistosoma mansoni tyrosinase precursor 0.0111 0.029 0.0447
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0057 0.012 0.5944
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0047 0.0432
Echinococcus granulosus TRP transient receptor potential channel 0.007 0.0159 0.0241
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0368 0.0365
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0011 0.0116
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0785 0.9399
Schistosoma mansoni hypothetical protein 0.0128 0.0344 0.0531
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0127 0.0427
Brugia malayi MAP kinase sur-1 0.0106 0.0273 0.0929
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0075 0.0176 0.1837
Loa Loa (eye worm) isocitrate dehydrogenase 0.003 0.0033 0.0105
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0071 0.0162 0.025
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0047 0.0072
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0068 0.0223
Schistosoma mansoni hypothetical protein 0.0064 0.014 0.0216
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0028
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0044 0.0041
Loa Loa (eye worm) hypothetical protein 0.0848 0.2615 0.8993
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.007 0.072
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0047 0.087
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0524 0.6229
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0101 0.0098
Schistosoma mansoni tar DNA-binding protein 0.0059 0.0125 0.0192
Brugia malayi MH1 domain containing protein 0.0033 0.0044 0.0142
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0125 0.0192
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0176 0.2001
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.007 0.0067
Echinococcus multilocularis protein patched 0.0041 0.0068 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0068 0.0688
Trypanosoma brucei heat shock protein, putative 0.0031 0.0038 0.0335
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0186 0.0183
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0038 0.0608
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0071 0.0162 0.4351
Plasmodium vivax vivapain-2 0.0034 0.0047 0.14
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0124 0.0409
Echinococcus granulosus transient receptor potential ion channel A 0.0181 0.051 0.0783
Leishmania major cathepsin L-like protease 0.013 0.0349 1
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0071 0.0162 0.0159
Echinococcus multilocularis cysteine protease 0.0034 0.0047 0.0044
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0368 0.0563
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0101 0.0349
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0071 0.0162 0.535
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0071 0.0162 0.0246
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0406 0.1219 0.4188
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.0349 1
Echinococcus multilocularis musashi 0.0028 0.0027 0.0024
Brugia malayi cathepsin L-like precursor 0.0023 0.0011 0.0028
Trichomonas vaginalis alpha-glucosidase, putative 0.0075 0.0176 0.2001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0068 0.0223
Echinococcus granulosus transient receptor potential gamma protein 0.0187 0.053 0.0813
Schistosoma mansoni NAD dehydrogenase 0.0071 0.0162 0.025
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0106 0.0273 0.7691
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0186 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7 uM Inhibition of Agaricus bisporus (mushroom) tyrosinase ChEMBL. 21476569
IC50 (ADMET) = 890 uM Inhibition of Oryctolagus cuniculus (rabbit) AOX in liver cytosol ChEMBL. 21476569

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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