Detailed information for compound 1852533

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 527.68 | Formula: C30H33N5O2S
  • H donors: 3 H acceptors: 4 LogP: 5.17 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C([C@@H]1CCC[C@@H](C1)NCc1ccc2c(c1)cccn2)Nc1ccc2c(c1)sc(n2)NC(=O)C1CCCC1
  • InChi: 1S/C30H33N5O2S/c36-28(20-5-1-2-6-20)35-30-34-26-13-11-24(17-27(26)38-30)33-29(37)22-7-3-9-23(16-22)32-18-19-10-12-25-21(15-19)8-4-14-31-25/h4,8,10-15,17,20,22-23,32H,1-3,5-7,9,16,18H2,(H,33,37)(H,34,35,36)/t22-,23+/m1/s1
  • InChiKey: ZKLJFVHPYJIZOP-PKTZIBPZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0017 0.0017
Trichomonas vaginalis hypothetical protein 0.0021 0.001 0.108
Brugia malayi MH2 domain containing protein 0.0013 0.0004 0.0004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.001 0.108
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0017 0.0017
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0014 0.0014
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0007 0.0007
Brugia malayi Cathepsin L-like precursor 0.0015 0.0005 0.0005
Brugia malayi Associated with TFs and helicases family protein 0.0021 0.001 0.001
Schistosoma mansoni chromobox protein 0.0021 0.001 0.001
Trichomonas vaginalis penicillin-binding protein, putative 0.0061 0.0041 0.4459
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0015
Brugia malayi Calcitonin receptor-like protein seb-1 0.004 0.0024 0.0024
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.004 0.004
Leishmania major cathepsin L-like protease 0.0015 0.0005 0.0653
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.004 0.6621
Plasmodium vivax vivapain-2 0.0015 0.0005 0.0857
Echinococcus multilocularis JmjC domain containing protein 4 0.0029 0.0016 0.0016
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Schistosoma mansoni smad1 5 8 and 0.0013 0.0004 0.0004
Echinococcus granulosus phd:f box containing protein 0.0029 0.0016 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0066 0.0066
Echinococcus granulosus cathepsin l1 0.0015 0.0005 0.0005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0048 0.003 0.3857
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0016
Echinococcus multilocularis jumonji domain containing 1A 0.0029 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.001
Brugia malayi SET domain containing protein 0.0021 0.001 0.001
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0028 0.0016 0.0016
Leishmania major cysteine peptidase A (CPA) 0.0015 0.0005 0.0653
Echinococcus granulosus chromobox protein 1 0.0127 0.0091 0.0091
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0017 0.2803
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0004 0.0004
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0017 0.2135
Brugia malayi Cathepsin L-like precursor 0.0015 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Brugia malayi Valyl-tRNA synthetase 0.0021 0.001 0.001
Brugia malayi hypothetical protein 0.0063 0.0042 0.0042
Schistosoma mansoni chromobox protein 0.0127 0.0091 0.0091
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0197 0.0145 0.494
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.0076 0.0076
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0001 0.0001
Echinococcus granulosus thioredoxin glutathione reductase 0.0086 0.006 0.006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0013 0.0004 0.0004
Echinococcus granulosus muscleblind protein 0.0165 0.012 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0037 0.6113
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0048 0.5313
Plasmodium vivax ataxin-2 like protein, putative 0.0063 0.0042 0.7013
Brugia malayi hypothetical protein 0.0021 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0001 0.0001
Trypanosoma cruzi PAB1-binding protein , putative 0.0063 0.0042 0.7013
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0021 0.001 0.001
Echinococcus multilocularis cpg binding protein 0.0027 0.0014 0.0014
Plasmodium vivax glutathione reductase, putative 0.0086 0.006 1
Brugia malayi MAP kinase sur-1 0.006 0.004 0.004
Mycobacterium tuberculosis Probable dehydrogenase 0.0197 0.0145 0.494
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0001 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0061 0.0041 0.4459
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Treponema pallidum exodeoxyribonuclease (exoA) 0.0016 0.0007 0.388
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.0005 0.0573
Mycobacterium tuberculosis Conserved protein 0.0061 0.0041 0.139
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.001
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.0016 0.264
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0021 0.001 0.001
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0001 0.0001
Loa Loa (eye worm) CXXC zinc finger family protein 0.0025 0.0013 0.0013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0001 0.0001
Leishmania major trypanothione reductase 0.0086 0.006 0.7617
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0001 0.0001
Trichomonas vaginalis Heterochromatin protein, putative 0.0021 0.001 0.108
Brugia malayi hypothetical protein 0.0041 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0027 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.0021 0.001 0.1633
Schistosoma mansoni hypothetical protein 0.0059 0.0039 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0001 0.0001
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0016 0.264
Echinococcus granulosus smad 0.0013 0.0004 0.0004
Loa Loa (eye worm) ctsf protein 0.0015 0.0005 0.0005
Brugia malayi beta-lactamase family protein 0.0061 0.0041 0.0041
Trichomonas vaginalis esterase, putative 0.0061 0.0041 0.4459
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0021 0.001 0.1633
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0197 0.0145 0.494
Echinococcus multilocularis smad 0.0013 0.0004 0.0004
Brugia malayi MH1 domain containing protein 0.0013 0.0004 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0014 0.1558
Echinococcus granulosus lamin dm0 0.0026 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0013 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0041 0.6784
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.108
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0071 0.0048 0.0048
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.004 0.5043
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0001 0.0001
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0016 0.2011
Plasmodium falciparum heterochromatin protein 1 0.0021 0.001 0.1643
Schistosoma mansoni serine/threonine protein kinase 0.006 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0061 0.0041 0.0041
Echinococcus granulosus intermediate filament protein 0.0026 0.0014 0.0014
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0017 0.2135
Schistosoma mansoni jumonji domain containing protein 0.0029 0.0016 0.0016
Loa Loa (eye worm) isocitrate dehydrogenase 0.0014 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0001 0.0157
Loa Loa (eye worm) hypothetical protein 0.0165 0.012 0.012
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0014 0.0014
Mycobacterium tuberculosis Probable oxidoreductase 0.0219 0.0161 0.5514
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0013 0.0004 0.0004
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0017 0.2135
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0001 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0059 0.0039 0.0039
Entamoeba histolytica cysteine protease, putative 0.0015 0.0005 0.0852
Onchocerca volvulus 0.001 0.0001 0.0121
Mycobacterium leprae Probable lipase LipE 0.0061 0.0041 0.2521
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0013 0.0004 0.0004
Leishmania major cathepsin L-like protease 0.0015 0.0005 0.0653
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0059 0.0039 0.0039
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0001 0.0001
Toxoplasma gondii thioredoxin reductase 0.0086 0.006 0.7617
Echinococcus granulosus mothers against decapentaplegic 5 0.0013 0.0004 0.0004
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0061 0.0041 0.139
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0001 0.0001
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0017 0.1843
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0016 0.0007 0.0223
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0007 0.0007
Brugia malayi beta-lactamase family protein 0.0061 0.0041 0.0041
Echinococcus multilocularis musashi 0.0026 0.0014 0.0014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0014 0.1558
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Schistosoma mansoni microtubule-associated protein tau 0.057 0.043 0.043
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0014 0.0005 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0005 0.0563
Trichomonas vaginalis chromobox protein, putative 0.0021 0.001 0.108
Echinococcus multilocularis mothers against decapentaplegic 5 0.0013 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.108
Echinococcus granulosus lamin 0.0026 0.0014 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0037 0.6113
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0017 0.2803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0001 0.0001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0012 0.1336
Loa Loa (eye worm) jmjC domain-containing protein 0.0109 0.0077 0.0077
Onchocerca volvulus 0.0056 0.0037 0.3108
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0017 0.2803
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0007 0.1088
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Onchocerca volvulus 0.0061 0.0041 0.3446
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0061 0.0041 0.139
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0017 0.2803
Brugia malayi Heterochromatin protein 1 0.0127 0.0091 0.0091
Brugia malayi jmjC domain containing protein 0.0029 0.0016 0.0016
Toxoplasma gondii exonuclease III APE 0.0016 0.0007 0.0828
Schistosoma mansoni cellular tumor antigen P53 0.0162 0.0118 0.0118
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0005 0.0573
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0061 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0016 0.0007 0.388
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.001
Brugia malayi hypothetical protein 0.0207 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.004 0.0024 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0017 0.2803
Mycobacterium leprae conserved hypothetical protein 0.0061 0.0041 0.2521
Echinococcus granulosus TGF beta signal transducer SmadC 0.0013 0.0004 0.0004
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0007 0.0715
Schistosoma mansoni jumonji/arid domain-containing protein 0.0109 0.0077 0.0077
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0016 0.0007 0.1088
Onchocerca volvulus Huntingtin homolog 0.0107 0.0076 0.6437
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0061 0.0041 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0005 0.0563
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0017 0.0017
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0061 0.0041 0.139
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0021 0.001 0.001
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0015 0.0005 0.0857
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0041 0.6784
Schistosoma mansoni aldehyde dehydrogenase 0.0111 0.0079 0.0079
Echinococcus multilocularis GPCR, family 2 0.0013 0.0004 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0001 0.0001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0005 0.0563
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0053 0.5767
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0001 0.0001
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0022 0.0011 0.0011
Echinococcus granulosus chromobox protein 1 0.0127 0.0091 0.0091
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0111 0.0079 0.0079
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0001 0.0001
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.004 0.004
Schistosoma mansoni phosphatidylserine receptor 0.0029 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0005 0.0563
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0001 0.0001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0061 0.0041 0.0041
Brugia malayi glutathione reductase 0.0086 0.006 0.006
Echinococcus multilocularis lamin 0.0026 0.0014 0.0014
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.071 0.0537 0.0537
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0001 0.0001
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0014 0.0005 0.0752
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0014 0.1558
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0014 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0087 0.006 0.006
Leishmania major cathepsin L-like protease 0.0056 0.0037 0.4656
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0014 0.0005 0.0752
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0021 0.001 0.001
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0005 0.0752
Mycobacterium tuberculosis Probable lipase LipD 0.0061 0.0041 0.139
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0017 0.2135
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0005 0.0563
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0016
Echinococcus granulosus lysine specific demethylase 5A 0.0109 0.0077 0.0077
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.004 0.6621
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.004 0.6621
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0001 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0001 0.0001
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0005 0.0005
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.001 0.1643
Plasmodium falciparum glutathione reductase 0.0086 0.006 1
Brugia malayi hypothetical protein 0.0059 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0005
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0021 0.001 0.1251
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0005 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0005 0.0852
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0014 0.1558
Onchocerca volvulus 0.0015 0.0005 0.0435
Loa Loa (eye worm) hypothetical protein 0.0061 0.0041 0.0041
Brugia malayi Cathepsin L-like precursor 0.001 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0005 0.0563
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0111 0.0079 0.0079
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0391 0.0293 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.001 0.108
Brugia malayi latrophilin 2 splice variant baaae 0.0027 0.0015 0.0015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0017 0.2803
Mycobacterium tuberculosis Probable reductase 0.0197 0.0145 0.494
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0017 0.2803
Echinococcus multilocularis chromobox protein 1 0.0127 0.0091 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0037 0.6113
Plasmodium vivax JmjC domain containing protein 0.0029 0.0016 0.264
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0017 1
Echinococcus granulosus alpha 16 mannosyl glycoprotein 1.3089 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0059 0.0039 0.0039
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0197 0.0145 0.494
Mycobacterium ulcerans aldehyde dehydrogenase 0.0111 0.0079 1
Echinococcus granulosus chromobox protein 2 0.0021 0.001 0.001
Entamoeba histolytica heat shock transcription factor, putative 0.0087 0.006 1
Brugia malayi isocitrate dehydrogenase 0.0014 0.0005 0.0005
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0015 0.0005 0.0005
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0015 0.0005 0.0857
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.0015 0.0005 0.0005
Schistosoma mansoni smad 0.0013 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0037 0.6113
Echinococcus multilocularis lamin dm0 0.0026 0.0014 0.0014
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0029 0.0016 0.0016
Echinococcus granulosus cathepsin l1 0.001 0.0001 0.0001
Brugia malayi M-phase phosphoprotein, mpp8 0.0021 0.001 0.001
Entamoeba histolytica heat shock transcription factor, putative 0.0087 0.006 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0007 0.1088
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0017 0.2803
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0001 0.0001
Echinococcus multilocularis muscleblind protein 1 0.0165 0.012 0.012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0005 0.0005
Brugia malayi nuclear receptor NHR-88 0.0009 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0066 0.0066
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0014 0.1558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0005 0.0563
Loa Loa (eye worm) hypothetical protein 0.0061 0.0041 0.0041
Echinococcus multilocularis lysine specific demethylase 6a 0.0029 0.0016 0.0016
Loa Loa (eye worm) cysteine protease 0.0015 0.0005 0.0005
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0014 0.0014
Brugia malayi Cathepsin L-like precursor 0.001 0.0001 0.0001
Onchocerca volvulus Cathepsin F homolog 0.0015 0.0005 0.0435
Trypanosoma cruzi trypanothione reductase, putative 0.0086 0.006 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0017 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0001 0.0001
Schistosoma mansoni protein phosphatase 2C 0.0029 0.0016 0.0016
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.004 0.6621
Trypanosoma brucei trypanothione reductase 0.0086 0.006 1
Mycobacterium tuberculosis Probable esterase LipL 0.0061 0.0041 0.139
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0017 0.0574
Onchocerca volvulus 0.0015 0.0005 0.0435
Brugia malayi Cathepsin L-like cysteine proteinase 0.001 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0059 0.0039 0.6502
Schistosoma mansoni hypothetical protein 0.0042 0.0026 0.0026
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0017 0.2803
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Conserved protein 0.0061 0.0041 0.139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0005 0.0563
Trypanosoma brucei PAB1-binding protein , putative 0.0063 0.0042 0.7013
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0005 0.0752
Brugia malayi Protein cec-1. 0.0021 0.001 0.001
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.004 0.004
Toxoplasma gondii LsmAD domain-containing protein 0.0063 0.0042 0.5342
Trichomonas vaginalis chromobox protein, putative 0.0127 0.0091 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0013 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0037 0.6113
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0041 0.6784
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0037 0.6113
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0012 0.0003 0.0003
Brugia malayi Smad1 0.0013 0.0004 0.0004
Schistosoma mansoni coup transcription factor 0.0009 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.108
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0013 0.0004 0.0004
Schistosoma mansoni cpg binding protein 0.0027 0.0014 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.006 0.004 0.4352
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.004 0.5043
Schistosoma mansoni chromobox protein 0.0021 0.001 0.001
Echinococcus multilocularis cathepsin L cysteine protease 0.0015 0.0005 0.0005
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0219 0.0161 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0005 0.0563
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.108
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.108
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0001 0.0001
Loa Loa (eye worm) thioredoxin reductase 0.0086 0.006 0.006
Trichomonas vaginalis D-aminoacylase, putative 0.0061 0.0041 0.4459
Trichomonas vaginalis CMGC family protein kinase 0.006 0.004 0.4352
Plasmodium vivax vivapain-2 0.0015 0.0005 0.0857
Schistosoma mansoni ap endonuclease 0.0016 0.0007 0.0007
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0014 0.0005 0.0154
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0001 0.0001
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0021 0.001 0.001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.004 0.0024 0.0024
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0015 0.0005 0.0005
Brugia malayi jmjC domain containing protein 0.0109 0.0077 0.0077
Loa Loa (eye worm) beta-lactamase 0.0061 0.0041 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0012 0.1301
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0061 0.0041 0.5167
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0219 0.0161 0.5514
Loa Loa (eye worm) fibroinase 0.0015 0.0005 0.0005
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0016 0.0007 0.1643
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.004 0.004
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0001 0.0001
Brugia malayi cathepsin L-like precursor 0.001 0.0001 0.0001
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0042 0.0026 0.0026
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0014 0.1558
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0037 0.6113
Loa Loa (eye worm) pigment dispersing factor receptor c 0.004 0.0024 0.0024
Entamoeba histolytica heat shock transcription factor, putative 0.0087 0.006 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0014 0.0005 0.0752
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0061 0.0041 0.0041
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0005 0.0852
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0012 0.0003 0.0003
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0021 0.001 0.1251
Echinococcus multilocularis cysteine protease 0.0015 0.0005 0.0005
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0005 0.0005
Echinococcus multilocularis cysteine protease 0.0015 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0033 0.3567
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0005 0.0005
Brugia malayi jmjC domain containing protein 0.0029 0.0016 0.0016
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0077 0.0053 0.4457
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0001 0.0059
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0016 0.2011
Plasmodium falciparum ataxin-2 like protein, putative 0.0063 0.0042 0.7013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0066 0.0066
Mycobacterium ulcerans beta-lactamase 0.0061 0.0041 0.5167
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0017 0.2803
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0001 0.0001
Loa Loa (eye worm) glutathione reductase 0.0086 0.006 0.006
Schistosoma mansoni Smad4 0.0013 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.0061 0.0041 0.5167
Trichomonas vaginalis CMGC family protein kinase 0.006 0.004 0.4352
Brugia malayi Isocitrate dehydrogenase 0.0014 0.0005 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.006 0.004 0.4352
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0016 0.264
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0051 0.0033 0.5494
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0033 0.3567
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0066 0.0066
Onchocerca volvulus 0.0162 0.0118 1
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0048 0.5313
Schistosoma mansoni hypothetical protein 0.0028 0.0016 0.0016
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0011 0.0011
Trypanosoma brucei protein kinase, putative 0.006 0.004 0.6621
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0017 0.2135
Brugia malayi chromobox protein homolog 3 0.0071 0.0048 0.0048
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.0016 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0061 0.0041 0.0041
Brugia malayi ecdysteroid receptor 0.0009 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0021 0.001 0.001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0061 0.0041 0.0041
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0017 0.4234
Echinococcus granulosus dnaJ subfamily B 0.0358 0.0268 0.0268
Brugia malayi intermediate filament protein 0.0026 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0107 0.0076 0.0076
Brugia malayi hypothetical protein 0.0107 0.0076 0.0076
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0207 0.0152 0.0152
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0066 0.0066
Mycobacterium tuberculosis Probable hydrolase 0.0061 0.0041 0.139
Schistosoma mansoni phd/f-box containing protein 0.0029 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0005 0.0563
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0022 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0001 0.0001
Echinococcus multilocularis chromobox protein 2 0.0021 0.001 0.001
Toxoplasma gondii cathepsin CPL 0.0015 0.0005 0.0653
Trichomonas vaginalis penicillin-binding protein, putative 0.0061 0.0041 0.4459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0005 0.0563
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.108
Onchocerca volvulus 0.0015 0.0005 0.0435
Trichomonas vaginalis D-aminoacylase, putative 0.0061 0.0041 0.4459
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0016 0.0007 0.1081
Loa Loa (eye worm) MH1 domain-containing protein 0.0013 0.0004 0.0004
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0111 0.0079 0.269
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0111 0.0079 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0061 0.0041 0.0041
Brugia malayi Cathepsin L-like precursor 0.0015 0.0005 0.0005
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0005 0.0563
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0001 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0061 0.0041 0.6784
Schistosoma mansoni hypothetical protein 0.0358 0.0268 0.0268
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0053 0.0035 0.0035
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0021 0.001 0.1643
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0004
Trichomonas vaginalis chromobox protein, putative 0.0021 0.001 0.108
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0007 0.1088
Echinococcus multilocularis tumor protein p63 0.1109 0.0842 0.0842
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.0076 0.0076
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0007 0.0715
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0017 0.0017
Onchocerca volvulus 0.0015 0.0005 0.0435
Echinococcus granulosus cathepsin l cysteine peptidase 0.0015 0.0005 0.0005
Schistosoma mansoni lamin 0.0026 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0013
Entamoeba histolytica cysteine proteinase, putative 0.001 0.0001 0.0238
Echinococcus granulosus GPCR family 2 0.0013 0.0004 0.0004
Schistosoma mansoni ap endonuclease 0.0016 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0005 0.0563
Brugia malayi jmjC domain containing protein 0.0029 0.0016 0.0016
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.0016 0.0016
Echinococcus multilocularis thioredoxin glutathione reductase 0.0086 0.006 0.006
Onchocerca volvulus 0.0021 0.001 0.0835
Brugia malayi CXXC zinc finger family protein 0.0025 0.0013 0.0013
Mycobacterium ulcerans aldehyde dehydrogenase 0.0111 0.0079 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0005 0.0563
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0004 0.0004
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0001 0.0001
Echinococcus granulosus survival motor neuron protein 1 0.0207 0.0152 0.0152
Echinococcus multilocularis beta LACTamase domain containing family member 0.0061 0.0041 0.0041
Schistosoma mansoni jumonji/arid domain-containing protein 0.0109 0.0077 0.0077
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0016 0.0007 0.0828
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0219 0.0161 0.5514
Brugia malayi Thioredoxin reductase 0.0086 0.006 0.006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0017 0.2803
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0021 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0001 0.0001
Echinococcus granulosus Chromobox protein 3 0.0021 0.001 0.001
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0197 0.0145 0.494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0001 0.0001
Plasmodium falciparum cysteine proteinase falcipain 3 0.0015 0.0005 0.0857
Schistosoma mansoni cathepsin F (C01 family) 0.001 0.0001 0.0001
Plasmodium vivax heterochromatin protein 1, putative 0.0021 0.001 0.1643
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0001 0.0059
Toxoplasma gondii aldehyde dehydrogenase 0.0111 0.0079 1
Onchocerca volvulus 0.0025 0.0013 0.1115
Schistosoma mansoni cpg binding protein 0.0027 0.0014 0.0014
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0053 0.5767
Leishmania major hypothetical protein, conserved 0.0063 0.0042 0.5342
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0016 0.0007 0.1088
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 1.3089 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0037 0.6113
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0005 0.0857
Echinococcus granulosus tumor protein p63 0.1109 0.0842 0.0842
Schistosoma mansoni hypothetical protein 0.0013 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0037 0.6113
Onchocerca volvulus 0.0061 0.0041 0.3446
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0014 0.1558
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.004 0.6621
Brugia malayi Cathepsin L-like precursor 0.0015 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.108
Mycobacterium ulcerans hypothetical protein 0.0061 0.0041 0.5167
Entamoeba histolytica hypothetical protein 0.0059 0.0039 0.6502
Leishmania major cathepsin L-like protease 0.0015 0.0005 0.0653
Entamoeba histolytica hypothetical protein 0.0021 0.001 0.1633
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0066 0.0066
Loa Loa (eye worm) heterochromatin protein 1 0.0127 0.0091 0.0091
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0022 0.0011 0.0011
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0017 0.2135
Loa Loa (eye worm) transcription factor SMAD2 0.0197 0.0144 0.0144
Loa Loa (eye worm) MH2 domain-containing protein 0.0013 0.0004 0.0004
Echinococcus multilocularis cathepsin L cysteine protease 0.0015 0.0005 0.0005
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0021 0.001 0.001
Loa Loa (eye worm) Smad1 0.0013 0.0004 0.0004
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0001 0.0001
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0017 0.2135
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0001 0.0001
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0017 0.1843
Brugia malayi jmjC domain containing protein 0.0107 0.0076 0.0076
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0197 0.0145 0.8958
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0005 0.0563
Mycobacterium tuberculosis Probable lipase LipE 0.0061 0.0041 0.139
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0001 0.0001
Onchocerca volvulus 0.0009 0.0001 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0005 0.0563
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.108
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0001 0.0001
Echinococcus granulosus geminin 0.0309 0.0231 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0015 0.0005 0.0563
Entamoeba histolytica hypothetical protein 0.0059 0.0039 0.6502
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0005 0.0563
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0014 0.0005 0.0005
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0071 0.0048 0.4106
Echinococcus multilocularis Smad4 0.0013 0.0004 0.0004
Plasmodium vivax thioredoxin reductase, putative 0.0086 0.006 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0001 0.0157
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0028 0.0016 0.0016
Schistosoma mansoni lamin 0.0026 0.0014 0.0014
Loa Loa (eye worm) CHromoDomain protein family member 0.0022 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0309 0.0231 0.0231
Plasmodium falciparum thioredoxin reductase 0.0086 0.006 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0017 0.2803
Echinococcus granulosus cathepsin L cysteine proteinase 0.0015 0.0005 0.0005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0005 0.0563
Echinococcus multilocularis geminin 0.0309 0.0231 0.0231
Schistosoma mansoni chromobox protein 0.0127 0.0091 0.0091
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0017 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0021 0.001 0.1633
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0001 0.0001
Echinococcus granulosus Chromo domain 0.0021 0.001 0.001
Brugia malayi steroid hormone receptor 0.0009 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0005 0.0563
Echinococcus multilocularis phd:f box containing protein 0.0029 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0037 0.0037
Onchocerca volvulus 0.0026 0.0014 0.1146
Mycobacterium ulcerans esterase/lipase LipP 0.0061 0.0041 0.5167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0037 0.6113
Echinococcus multilocularis dnaJ subfamily B 0.0358 0.0268 0.0268
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0017 0.2135
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0017 0.2803
Onchocerca volvulus Huntingtin homolog 0.0107 0.0076 0.6437
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0015 0.0005 0.0005
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0021 0.001 0.1633
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0001 0.0001
Echinococcus multilocularis chromobox protein 1 0.0127 0.0091 0.0091
Brugia malayi CHD4 protein 0.0022 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 1.3089 1 1
Onchocerca volvulus 0.0021 0.001 0.0835
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0001 0.0001
Trichomonas vaginalis chromobox protein, putative 0.0021 0.001 0.108
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Onchocerca volvulus 0.0015 0.0005 0.0435
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0111 0.0079 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0066 0.0066
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0087 0.006 0.5111
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0078 0.0054 0.8942
Plasmodium falciparum ataxin-2 like protein, putative 0.0063 0.0042 0.7013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0005 0.0563
Trypanosoma cruzi cruzipain precursor, putative 0.0056 0.0037 0.6113
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0001 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0005 0.0563
Entamoeba histolytica hypothetical protein 0.0021 0.001 0.1633
Brugia malayi MH2 domain containing protein 0.0197 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0162 0.0118 0.0118
Brugia malayi MH1 domain containing protein 0.0013 0.0004 0.0004
Echinococcus granulosus cpg binding protein 0.0027 0.0014 0.0014
Onchocerca volvulus 0.0021 0.001 0.087
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0013 0.0004 0.0004
Loa Loa (eye worm) helicase 0.0021 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0001 0.0001
Onchocerca volvulus 0.0026 0.0014 0.1146
Schistosoma mansoni intermediate filament proteins 0.0026 0.0014 0.0014
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0017 0.2135
Plasmodium falciparum thioredoxin reductase 0.003 0.0017 0.2803
Plasmodium vivax hypothetical protein, conserved 0.0021 0.001 0.1643
Onchocerca volvulus 0.0015 0.0005 0.0435
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0013 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0001 0.0001
Onchocerca volvulus Cathepsin L homolog 0.0015 0.0005 0.0435
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.0005 0.0573
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0014 0.0005 0.0752
Schistosoma mansoni hypothetical protein 0.0013 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.0059 0.0039 0.6502
Leishmania major cathepsin L-like protease 0.0015 0.0005 0.0653
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0037 0.6113
Onchocerca volvulus 0.0015 0.0005 0.0435
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0017 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0017 0.2803
Echinococcus multilocularis isocitrate dehydrogenase 0.0014 0.0005 0.0005
Echinococcus granulosus microtubule associated protein 2 0.057 0.043 0.043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0037 0.6113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0005 0.0563
Loa Loa (eye worm) MH2 domain-containing protein 0.0197 0.0144 0.0144
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0029 0.0016 0.2011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0037 0.6113
Schistosoma mansoni smad1 5 8 and 0.0013 0.0004 0.0004
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0016 0.0007 0.0828
Trypanosoma cruzi PAB1-binding protein , putative 0.0063 0.0042 0.7013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0015 0.0005 0.0563
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.004 0.5043
Plasmodium falciparum glutathione reductase 0.003 0.0017 0.2803
Schistosoma mansoni survival motor neuron protein 0.0042 0.0026 0.0026
Schistosoma mansoni smad1 5 8 and 0.0013 0.0004 0.0004
Echinococcus multilocularis survival motor neuron protein 1 0.0207 0.0152 0.0152
Brugia malayi Cathepsin L-like precursor 0.0015 0.0005 0.0005
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0078 0.0054 0.0054
Treponema pallidum NADH oxidase 0.003 0.0017 1
Brugia malayi jmjC domain containing protein 0.0029 0.0016 0.0016
Onchocerca volvulus 0.0061 0.0041 0.3446
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0021 0.001 0.1251
Leishmania major cathepsin L-like protease 0.0056 0.0037 0.4656
Echinococcus multilocularis Chromobox protein 3 0.0021 0.001 0.001
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0107 0.0076 0.0076
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0001 0.0001
Echinococcus multilocularis Chromo domain 0.0021 0.001 0.001
Giardia lamblia Kinase, CMGC MAPK 0.006 0.004 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.001
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 1.3089 1 1
Brugia malayi MH2 domain containing protein 0.0013 0.0004 0.0004
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0012 0.1336
Trichomonas vaginalis chromobox protein, putative 0.0127 0.0091 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.012 0.012
Trypanosoma cruzi major cysteine proteinase, putative 0.0044 0.0027 0.4588
Leishmania major cathepsin L-like protease 0.0056 0.0037 0.4656
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0005 0.0563
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0017 0.2803
Echinococcus granulosus mitogen activated protein kinase 0.006 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0063 0.0042 0.0042
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0001 0.0001
Echinococcus granulosus Smad4 0.0013 0.0004 0.0004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0014 0.1558
Echinococcus multilocularis muscleblind protein 0.0165 0.012 0.012
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0086 0.006 0.2049
Plasmodium vivax hypothetical protein, conserved 0.0021 0.001 0.1643
Mycobacterium tuberculosis Conserved protein 0.0061 0.0041 0.139
Brugia malayi HSF-type DNA-binding domain containing protein 0.0087 0.006 0.006
Brugia malayi nuclear hormone receptor 0.0009 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0066 0.0066
Echinococcus multilocularis microtubule associated protein 2 0.057 0.043 0.043
Schistosoma mansoni hypothetical protein 0.0309 0.0231 0.0231
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0007 0.0007
Toxoplasma gondii ABC1 family protein 0.0061 0.0041 0.5167
Schistosoma mansoni jumonji domain containing protein 0.0107 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0013 0.0004 0.0004
Echinococcus multilocularis lysine specific demethylase 5A 0.0107 0.0076 0.0076
Brugia malayi Muscleblind-like protein 0.0165 0.012 0.012
Schistosoma mansoni aldehyde dehydrogenase 0.0111 0.0079 0.0079
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0037 0.6113
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0017 0.2803
Loa Loa (eye worm) hypothetical protein 0.0061 0.0041 0.0041
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0016 0.264
Schistosoma mansoni cpg binding protein 0.0025 0.0013 0.0013
Leishmania major cathepsin L-like protease 0.0015 0.0005 0.0653
Brugia malayi beta-lactamase 0.0061 0.0041 0.0041
Onchocerca volvulus 0.0042 0.0026 0.2222
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0078 0.0054 0.8942
Mycobacterium ulcerans lipase LipD 0.0061 0.0041 0.5167
Onchocerca volvulus Cathepsin L homolog 0.0015 0.0005 0.0435

Activities

Activity type Activity value Assay description Source Reference
MIC80 (functional) = 4 ug ml-1 Antifungal activity against Cryptococcus neoformans after 72 hrs by serial dilution method ChEMBL. No reference
MIC80 (functional) = 4 ug ml-1 Antifungal activity against Candida albicans after 24 hrs by serial dilution method ChEMBL. No reference
Survival (functional) = 60 % Antifungal activity against Candida albicans SC5314 infected in Caenorhabditis elegans assessed as nematode survival at 16 ug/ml after 144 hrs by serial dilution method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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