Detailed information for compound 1853355

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 637.846 | Formula: C38H55NO7
  • H donors: 2 H acceptors: 5 LogP: 6.74 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)O[C@H](C(O)(C)C)[C@@H]1C[C@@H](C)[C@H]2[C@H](O1)[C@H](O)[C@@]1([C@]2(C)CC[C@@]23[C@H]1CC[C@@H]1[C@]3(C2)CC[C@@H](C1(C)C)OC(=O)c1ccncc1)C
  • InChi: 1S/C38H55NO7/c1-21-19-24(31(34(5,6)43)44-22(2)40)45-29-28(21)35(7)15-16-38-20-37(38)14-11-27(46-32(42)23-12-17-39-18-13-23)33(3,4)25(37)9-10-26(38)36(35,8)30(29)41/h12-13,17-18,21,24-31,41,43H,9-11,14-16,19-20H2,1-8H3/t21-,24+,25+,26+,27+,28+,29+,30+,31+,35-,36-,37-,38+/m1/s1
  • InChiKey: BAUZJPNZCDKMMK-BTZANBMOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APH1B gamma secretase subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Echinococcus granulosus gamma secretase subunit aph 1 Get druggable targets OG5_130831 All targets in OG5_130831
Schistosoma japonicum ko:K06172 anterior pharynx defective 1, putative Get druggable targets OG5_130831 All targets in OG5_130831
Loa Loa (eye worm) gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Brugia malayi gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Echinococcus multilocularis gamma secretase subunit aph 1 Get druggable targets OG5_130831 All targets in OG5_130831
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Trypanosoma cruzi cruzipain precursor, putative 0.006 0.028 0.2901
Brugia malayi beta-lactamase family protein 0.0029 0.0084 0.0468
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0033 0.0108 0.133
Loa Loa (eye worm) hypothetical protein 0.0037 0.0136 0.0228
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0053 0.0053
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0005 0.0009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0043 0.0185
Echinococcus multilocularis zinc finger protein 0.0016 0.0002 0.0002
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0053 0.0053
Echinococcus granulosus endoplasmin 0.0129 0.072 0.072
Brugia malayi neuropeptide F receptor 0.0024 0.0053 0.0296
Echinococcus granulosus fmrfamide receptor 0.0024 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Plasmodium falciparum DNA gyrase subunit B 0.0033 0.0108 0.1112
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.028 0.2901
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0029 0.0084 0.0141
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0053 0.0296
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0057
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0005 0.0009
Brugia malayi diacylglycerol acyltransferase 0.0093 0.0491 0.2737
Onchocerca volvulus 0.0046 0.0194 0.1055
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0033 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.028 0.2901
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0057
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Schistosoma mansoni ran 0.0021 0.003 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0053 0.0089
Loa Loa (eye worm) PHD-finger family protein 0.0017 0.0008 0.0013
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.1399 0.2341
Loa Loa (eye worm) beta-lactamase 0.0029 0.0084 0.0141
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0053 0.0089
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0053 0.0053
Onchocerca volvulus 0.0024 0.0053 0.0268
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0033 0.0108 0.1025
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0053 0.0053
Schistosoma mansoni histamine h1 receptor 0.0024 0.0053 0.0089
Toxoplasma gondii hypothetical protein 0.0093 0.0491 0.051
Mycobacterium tuberculosis Probable hydrolase 0.0029 0.0084 0.0651
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0033 0.0108 0.133
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0033 0.0108 0.1331
Loa Loa (eye worm) hypothetical protein 0.0029 0.0084 0.0141
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0053 0.0053
Echinococcus multilocularis serotonin receptor 0.0024 0.0053 0.0053
Plasmodium falciparum plasmepsin VI 0.0071 0.0352 0.3749
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0033 0.0108 0.0875
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0264 0.1583 1
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0108 0.1112
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0053 0.0089
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Schistosoma mansoni ran 0.0021 0.003 0.005
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0053 0.0053
Giardia lamblia Grp94/Hsp90 0.0129 0.072 0.4502
Echinococcus granulosus snurportin 1 0.03 0.1813 0.1813
Echinococcus granulosus heat shock protein 0.0162 0.0931 0.0931
Onchocerca volvulus 0.0029 0.0084 0.0441
Onchocerca volvulus 0.0037 0.0136 0.0731
Loa Loa (eye worm) hypothetical protein 0.0098 0.0525 0.0878
Leishmania major cathepsin L-like protease 0.006 0.028 0.2901
Echinococcus granulosus neuropeptide receptor 0.0024 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Trypanosoma brucei heat shock protein 90, putative 0.0162 0.0931 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0053 0.0053
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0053 0.0053
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0033 0.0108 0.1025
Mycobacterium ulcerans esterase/lipase LipP 0.0029 0.0084 0.099
Plasmodium vivax DNA gyrase subunit B, putative 0.0033 0.0108 0.1112
Mycobacterium leprae Probable two component sensor kinase MprB 0.0033 0.0108 0.0378
Schistosoma mansoni hypothetical protein 0.0093 0.0491 0.0822
Onchocerca volvulus 0.0024 0.0053 0.0268
Loa Loa (eye worm) hypothetical protein 0.0032 0.0103 0.0172
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0038 0.0063
Schistosoma mansoni hypothetical protein 0.0031 0.0096 0.0161
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0084 0.0763
Trypanosoma cruzi major cysteine proteinase, putative 0.0047 0.0198 0.2008
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0093 0.0491 0.0491
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0033 0.0108 0.0108
Trichomonas vaginalis esterase, putative 0.0029 0.0084 0.0446
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.003 0.0171
Brugia malayi MBOAT family protein 0.0093 0.0491 0.2737
Onchocerca volvulus 0.0024 0.0053 0.0268
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0093 0.0491 0.0491
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0093 0.0491 0.0822
Entamoeba histolytica hypothetical protein, conserved 0.0093 0.0491 0.3043
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0033 0.0108 0.0599
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Echinococcus granulosus o acyltransferase membrane bound domain 0.0093 0.0491 0.0491
Trichomonas vaginalis heat shock protein, putative 0.0066 0.0321 0.1956
Loa Loa (eye worm) hypothetical protein 0.0093 0.0491 0.0822
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Brugia malayi PHD-finger family protein 0.0021 0.0031 0.0172
Giardia lamblia Pms1-like protein 0.0033 0.0108 0.0599
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0043 0.0185
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0053 0.0089
Trypanosoma cruzi Aph-1 protein, putative 0.0115 0.0635 0.6768
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0053 0.0089
Trichomonas vaginalis transmembrane protein nessy, putative 0.0093 0.0491 0.3043
Schistosoma mansoni hypothetical protein 0.0017 0.0008 0.0013
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0093 0.0491 0.0491
Brugia malayi Eukaryotic aspartyl protease family protein 0.0017 0.0005 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0033 0.0108 0.133
Onchocerca volvulus 0.0037 0.0136 0.0731
Trichomonas vaginalis heat shock protein, putative 0.0129 0.072 0.4502
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0053 0.0053
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0053 0.0296
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0053 0.0053
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0019 0.0018 0.003
Trypanosoma cruzi DNA topoisomerase II, putative 0.0033 0.0108 0.1025
Trichomonas vaginalis porcupine, putative 0.0093 0.0491 0.3043
Trichomonas vaginalis ran, putative 0.0021 0.003 0.01
Schistosoma mansoni neuropeptide receptor 0.0024 0.0053 0.0089
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0024 0.0053 0.0053
Chlamydia trachomatis DNA gyrase subunit B 0.0033 0.0108 0.5
Brugia malayi hypothetical protein 0.0024 0.0053 0.0296
Plasmodium vivax importin-beta 2, putative 0.0028 0.0077 0.0778
Brugia malayi RE15519p 0.0024 0.0053 0.0296
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Brugia malayi hypothetical protein 0.0024 0.0053 0.0296
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0129 0.072 0.072
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0053 0.0053
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0053 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0053 0.0089
Plasmodium vivax heat shock protein 90, putative 0.0066 0.0321 0.3412
Loa Loa (eye worm) MBOAT family protein 0.0093 0.0491 0.0822
Brugia malayi MBOAT family protein 0.0093 0.0491 0.2737
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0037 0.0136 0.0228
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0005 0.0009
Schistosoma mansoni importin beta-1 0.0028 0.0077 0.0129
Leishmania major hypothetical protein, conserved 0.0033 0.0108 0.1025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0053 0.0089
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0096 0.0535
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0129 0.072 0.6576
Echinococcus granulosus neuropeptide receptor 0.0024 0.0053 0.0053
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0129 0.0721 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0264 0.1583 1
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0053 0.0053
Schistosoma mansoni DNA topoisomerase II 0.0033 0.0108 0.0181
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0021 0.0034 0.0191
Mycobacterium tuberculosis Conserved protein 0.0029 0.0084 0.0651
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0017 0.0005 0.0009
Onchocerca volvulus 0.0029 0.0084 0.0441
Schistosoma mansoni sterol O-acyltransferase 1 0.0951 0.5977 1
Echinococcus granulosus sex peptide receptor 0.0024 0.0053 0.0053
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0093 0.0491 0.0491
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0053 0.0053
Brugia malayi MBOAT family protein 0.0093 0.0491 0.2737
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0053 0.0053
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0053 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0491 0.3043
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0033 0.0108 0.1112
Brugia malayi G-protein coupled receptor 0.0024 0.0053 0.0296
Echinococcus granulosus gamma secretase subunit aph 1 0.0296 0.1789 0.1789
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0053 0.0089
Schistosoma mansoni hypothetical protein 0.0024 0.0053 0.0089
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0053 0.0053
Brugia malayi Dopamine receptor protein 2 0.0024 0.0053 0.0296
Brugia malayi Dopamine receptor protein 1 0.0024 0.0053 0.0296
Leishmania major developmentally regulated phosphoprotein-like protein 0.0033 0.0108 0.1025
Plasmodium falciparum heat shock protein 90, putative 0.0066 0.0321 0.3412
Brugia malayi hypothetical protein 0.0024 0.0053 0.0296
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0093 0.0491 0.0822
Schistosoma mansoni amine GPCR 0.0024 0.0053 0.0089
Leishmania major GTP-binding protein, putative 0.0021 0.003 0.0171
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Schistosoma mansoni memapsin-2 (A01 family) 0.0017 0.0005 0.0009
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0033 0.0108 0.0599
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0053 0.0053
Schistosoma mansoni bromodomain containing protein 0.0053 0.0236 0.0395
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0033 0.0108 0.0575
Echinococcus granulosus hypothetical protein 0.0024 0.0053 0.0053
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0033 0.0108 0.0108
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0084 0.0446
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0053 0.0053
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0053 0.0053
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0033 0.0108 0.0599
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0005 0.0009
Leishmania major cathepsin L-like protease 0.006 0.028 0.2901
Brugia malayi follicle stimulating hormone receptor 0.0024 0.0053 0.0296
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0053 0.0089
Brugia malayi G protein-coupled receptor 0.0024 0.0053 0.0296
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0053 0.0089
Trichomonas vaginalis sensor histidine kinase, putative 0.0033 0.0108 0.0599
Echinococcus granulosus orexin receptor type 2 0.0024 0.0053 0.0053
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0033 0.0108 0.0875
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0033 0.0108 0.0875
Mycobacterium tuberculosis Conserved protein 0.0029 0.0084 0.0651
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0053 0.0296
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0033 0.0108 0.1025
Brugia malayi Importin beta-1 subunit 0.0028 0.0077 0.043
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0053 0.0053
Plasmodium falciparum DNA topoisomerase 2 0.0033 0.0108 0.1112
Trichomonas vaginalis heat shock protein, putative 0.0129 0.072 0.4502
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0014 0.0024
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0053 0.0053
Brugia malayi neuropeptide F receptor 0.0024 0.0053 0.0296
Brugia malayi larval opioid receptor 0.0024 0.0053 0.0296
Plasmodium vivax heat shock protein 86, putative 0.0162 0.0931 1
Brugia malayi sulfakinin receptor protein 0.0024 0.0053 0.0296
Entamoeba histolytica hypothetical protein 0.0023 0.0043 0.0185
Schistosoma mansoni pyruvate dehydrogenase 0.0033 0.0108 0.0181
Brugia malayi beta-lactamase 0.0029 0.0084 0.0468
Leishmania major cathepsin L-like protease 0.006 0.028 0.2901
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0053 0.0089
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0053 0.0053
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0066 0.0321 0.1956
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.028 0.2901
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0033 0.0108 0.0378
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0033 0.0108 0.0599
Echinococcus granulosus sterol O acyltransferase 1 0.0951 0.5977 0.5977
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0033 0.0108 0.1025
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0033 0.0108 0.0108
Schistosoma mansoni neuropeptide receptor 0.0024 0.0053 0.0089
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0053 0.0089
Trypanosoma brucei heat shock protein 90, putative 0.0162 0.0931 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0096 0.0096
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0053 0.0053
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0053 0.0089
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0084 0.0141
Mycobacterium ulcerans DNA gyrase subunit B 0.0033 0.0108 0.133
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0053 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0264 0.1583 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0093 0.0491 0.3043
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0053 0.0089
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0053 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0084 0.0763
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0057
Schistosoma mansoni heat shock protein 0.0066 0.0321 0.0537
Loa Loa (eye worm) hypothetical protein 0.0858 0.5383 0.9007
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0093 0.0491 0.0822
Echinococcus multilocularis heat shock protein 0.0162 0.0931 0.0931
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0096 0.0161
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0093 0.0491 0.0822
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0053 0.0053
Echinococcus granulosus serotonin receptor 0.0024 0.0053 0.0053
Echinococcus granulosus g protein coupled receptor 0.0024 0.0053 0.0053
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0033 0.0108 0.133
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0118 0.0652 0.0652
Chlamydia trachomatis DNA gyrase subunit B 0.0033 0.0108 0.5
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0043 0.0317
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0066 0.0321 0.0321
Trypanosoma cruzi GUP1, putative 0.0093 0.0491 0.5208
Echinococcus granulosus o acyltransferase membrane bound domain 0.0093 0.0491 0.0491
Trichomonas vaginalis DNA topoisomerase II, putative 0.0033 0.0108 0.0599
Loa Loa (eye worm) MBOAT family protein 0.0093 0.0491 0.0822
Schistosoma mansoni hypothetical protein 0.0024 0.0053 0.0089
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0033 0.0108 0.0875
Plasmodium falciparum heat shock protein 90, putative 0.0066 0.0321 0.3412
Treponema pallidum alginate O-acetylation protein (algI) 0.0093 0.0491 0.3043
Schistosoma mansoni myosin xvIII 0.0024 0.0053 0.0089
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0033 0.0108 0.0875
Mycobacterium ulcerans two component sensor kinase MprB 0.0033 0.0108 0.133
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0053 0.0053
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0057
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0053 0.0053
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0084 0.0446
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0014 0.0078
Echinococcus multilocularis tumor protein p63 0.0317 0.1922 0.1922
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0093 0.0491 0.051
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0053 0.0053
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0033 0.0108 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.028 0.2901
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0053 0.0089
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0118 0.0652 0.1091
Brugia malayi hypothetical protein 0.0024 0.0053 0.0296
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0014 0.0097
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0053 0.0296
Trypanosoma brucei heat shock protein 84, putative 0.0066 0.0321 0.3348
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0033 0.0108 0.0875
Onchocerca volvulus 0.0024 0.0053 0.0268
Onchocerca volvulus 0.0037 0.0136 0.0731
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.1399 0.2341
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.003 0.003
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0296 0.1789 0.2993
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0053 0.0053
Mycobacterium ulcerans putative regultory protein 0.0033 0.0108 0.133
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0053 0.0296
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0093 0.0491 0.0491
Schistosoma mansoni ap endonuclease 0.0018 0.0014 0.0024
Leishmania major glycerol uptake protein, putative 0.0093 0.0491 0.5208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.028 0.2901
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0033 0.0108 0.0378
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0033 0.0108 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0053 0.0268
Leishmania major hypothetical protein, conserved 0.0029 0.0084 0.0763
Plasmodium falciparum plasmepsin I 0.0071 0.0352 0.3749
Treponema pallidum heat shock protein 90 0.0129 0.072 0.4502
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0037 0.0136 0.0758
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0066 0.0321 0.0321
Giardia lamblia Heat shock protein HSP 90-alpha 0.0129 0.072 0.4502
Mycobacterium leprae Probable two-component sensor kinase 0.0033 0.0108 0.0378
Leishmania major hypothetical protein, conserved 0.0093 0.0491 0.5208
Brugia malayi gamma-secretase subunit aph-1 0.0296 0.1789 0.9962
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Schistosoma mansoni biogenic amine receptor 0.0024 0.0053 0.0089
Loa Loa (eye worm) hhat protein 0.0093 0.0491 0.0822
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0053 0.0089
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0053 0.0296
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0053 0.0053
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0525 0.2922
Schistosoma mansoni opsin-like receptor 0.0024 0.0053 0.0089
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0033 0.0108 0.1331
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0264 0.1583 1
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0326 0.1817
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0053 0.0053
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0033 0.0108 0.0875
Echinococcus granulosus neuropeptide receptor A26 0.0024 0.0053 0.0053
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0033 0.0108 0.1025
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.1509 0.9542 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0326 0.0546
Schistosoma mansoni hypothetical protein 0.0024 0.0053 0.0089
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.158 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0053 0.0089
Mycobacterium tuberculosis Conserved protein 0.0029 0.0084 0.0651
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0093 0.0491 0.0491
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0053 0.0053
Trypanosoma cruzi heat shock protein, putative 0.0066 0.0321 0.3348
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0053 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.028 0.2901
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0093 0.0491 0.051
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0053 0.0053
Brugia malayi hypothetical protein 0.0024 0.0053 0.0296
Brugia malayi beta-lactamase family protein 0.0029 0.0084 0.0468
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.003 0.0026
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0093 0.0491 0.0822
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.028 0.2901
Mycobacterium tuberculosis Probable two component sensor kinase 0.0033 0.0108 0.0875
Mycobacterium ulcerans heat shock protein 90 0.0129 0.072 0.9993
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0093 0.0491 0.0491
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0053 0.0053
Schistosoma mansoni cellular tumor antigen P53 0.0046 0.0194 0.0325
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Leishmania major heat shock protein, putative 0.0066 0.0321 0.3348
Schistosoma mansoni hypothetical protein 0.0067 0.0326 0.0546
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Schistosoma mansoni cathepsin D (A01 family) 0.0071 0.0352 0.0589
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0084 0.0446
Brugia malayi MBOAT family protein 0.0093 0.0491 0.2737
Trichomonas vaginalis heat shock protein, putative 0.0099 0.0531 0.3298
Brugia malayi hypothetical protein 0.0024 0.0053 0.0296
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.005 0.0217 0.0217
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0053 0.0089
Brugia malayi kinase, mitochondrial precursor 0.0033 0.0108 0.0602
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0053 0.0053
Echinococcus granulosus beta LACTamase domain containing family member 0.0029 0.0084 0.0084
Echinococcus granulosus heat shock protein 90 0.0129 0.072 0.072
Schistosoma mansoni amine GPCR 0.0024 0.0053 0.0089
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0053 0.0089
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0264 0.1583 1
Loa Loa (eye worm) hypothetical protein 0.0297 0.1795 0.3004
Trichomonas vaginalis endoplasmin, putative 0.0099 0.0531 0.3298
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.003 0.009 0.009
Brugia malayi ORL1-like opioid receptor 0.0024 0.0053 0.0296
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Trypanosoma brucei DNA topoisomerase ii 0.0033 0.0108 0.1025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0053 0.0053
Schistosoma mansoni heat shock protein 0.0162 0.0931 0.1557
Loa Loa (eye worm) TOPoisomerase family member 0.0033 0.0108 0.0181
Loa Loa (eye worm) hypothetical protein 0.0046 0.0194 0.0325
Loa Loa (eye worm) hypothetical protein 0.0071 0.0352 0.0589
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0053 0.0296
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0033 0.0108 0.1025
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0053 0.0053
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0014 0.0014
Onchocerca volvulus 0.0037 0.0136 0.0731
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Leishmania major glycerol uptake protein, putative 0.0093 0.0491 0.5208
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0055 0.0247 0.2539
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.003 0.0266
Echinococcus multilocularis endoplasmin 0.0129 0.072 0.072
Trypanosoma cruzi heat shock protein 85, putative 0.0162 0.0931 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0053 0.0089
Loa Loa (eye worm) heat shock protein 90 0.0162 0.0931 0.1557
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0053 0.0053
Entamoeba histolytica heat shock protein 90, putative 0.0162 0.0931 0.5844
Trypanosoma cruzi heat shock protein 90, putative 0.0129 0.072 0.7705
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Onchocerca volvulus 0.0037 0.0136 0.0731
Leishmania major glycerol uptake protein, putative 0.0093 0.0491 0.5208
Echinococcus multilocularis somatostatin receptor 0.0024 0.0053 0.0053
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0033 0.0108 0.0575
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0033 0.0108 0.133
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0093 0.0491 0.0822
Echinococcus granulosus g protein coupled receptor 0.0024 0.0053 0.0053
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Onchocerca volvulus 0.0093 0.0491 0.2716
Trypanosoma brucei heat shock protein, putative 0.0162 0.0931 1
Toxoplasma gondii ABC1 family protein 0.0029 0.0084 0.0083
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Echinococcus multilocularis beta LACTamase domain containing family member 0.0029 0.0084 0.0084
Echinococcus multilocularis heat shock protein 90 0.0129 0.072 0.072
Schistosoma mansoni hypothetical protein 0.0031 0.0096 0.0161
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0033 0.0108 0.133
Echinococcus multilocularis neuropeptide receptor A26 0.0024 0.0053 0.0053
Schistosoma mansoni opsin-like receptor 0.0024 0.0053 0.0089
Onchocerca volvulus 0.0024 0.0053 0.0268
Leishmania major glycerol uptake protein, putative 0.0093 0.0491 0.5208
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0096 0.0535
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.028 0.2901
Brugia malayi hypothetical protein 0.0021 0.0034 0.0191
Onchocerca volvulus 0.0024 0.0053 0.0268
Entamoeba histolytica DNA topoisomerase II, putative 0.0033 0.0108 0.0599
Onchocerca volvulus 0.0024 0.0053 0.0268
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0129 0.072 0.9992
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0084 0.0446
Onchocerca volvulus 0.0024 0.0053 0.0268
Schistosoma mansoni ap endonuclease 0.0018 0.0014 0.0024
Schistosoma mansoni amine GPCR 0.0024 0.0053 0.0089
Leishmania major mitochondrial DNA topoisomerase II 0.0033 0.0108 0.1025
Loa Loa (eye worm) hypothetical protein 0.0951 0.5977 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0024 0.0053 0.0089
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0033 0.0108 0.0602
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.003 0.0171
Trypanosoma brucei developmentally regulated phosphoprotein 0.0033 0.0108 0.1025
Loa Loa (eye worm) hypothetical protein 0.0059 0.0276 0.0461
Entamoeba histolytica hypothetical protein 0.0093 0.0491 0.3043
Brugia malayi AKH receptor 0.0024 0.0053 0.0296
Onchocerca volvulus 0.0029 0.0084 0.0441
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0033 0.0108 0.0875
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0181
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0084 0.0852
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0053 0.0053
Trypanosoma cruzi heat shock protein 85, putative 0.0162 0.0931 1
Toxoplasma gondii DNA topoisomerase 2, putative 0.0033 0.0108 0.0108
Mycobacterium ulcerans hypothetical protein 0.0029 0.0084 0.099
Brugia malayi Serotonin receptor 0.0024 0.0053 0.0296
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0264 0.1583 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0053 0.0053
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.003 0.01
Toxoplasma gondii aspartyl protease ASP1 0.0071 0.0352 0.0364
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0029 0.0084 0.099
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Brugia malayi Serotonin receptor 0.0024 0.0053 0.0296
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0043 0.0185
Loa Loa (eye worm) hypothetical protein 0.0031 0.0096 0.0161
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0053 0.0089
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0093 0.0491 0.0822
Brugia malayi hypothetical protein 0.0024 0.0053 0.0296
Trypanosoma brucei glycerol uptake protein, putative 0.0093 0.0491 0.5208
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0021 0.0034 0.0191
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0053 0.0053
Echinococcus granulosus zinc finger protein 0.0016 0.0002 0.0002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0118 0.0652 0.3633
Loa Loa (eye worm) hypothetical protein 0.0034 0.0115 0.0193
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0021 0.0034 0.0057
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0057
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0118 0.0652 0.0652
Brugia malayi Endoplasmin precursor 0.0162 0.0931 0.5184
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0019 0.0018 0.0018
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0033 0.0108 0.1331
Schistosoma mansoni hypothetical protein 0.03 0.1813 0.3034
Loa Loa (eye worm) hypothetical protein 0.0093 0.0491 0.0822
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0021 0.0034 0.0057
Loa Loa (eye worm) hypothetical protein 0.0029 0.0084 0.0141
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0053 0.0296
Mycobacterium tuberculosis Probable esterase LipL 0.0029 0.0084 0.0651
Echinococcus multilocularis neuropeptide s receptor 0.0024 0.0053 0.0053
Echinococcus granulosus GPCR family 2 0.0031 0.0096 0.0096
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0033 0.0108 0.133
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0033 0.0108 0.0108
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0053 0.0053
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0053 0.0053
Trypanosoma brucei Heat shock protein 83, putative 0.0162 0.0931 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Brugia malayi G-protein coupled receptor 0.0024 0.0053 0.0296
Toxoplasma gondii heat shock protein HSP90 0.0162 0.0931 0.0971
Trypanosoma cruzi glycerol uptake protein, putative 0.0093 0.0491 0.5208
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0053 0.0053
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0186 0.1088 1
Onchocerca volvulus 0.0037 0.0136 0.0731
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Toxoplasma gondii exonuclease III APE 0.0018 0.0014 0.0009
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0033 0.0108 0.0599
Mycobacterium tuberculosis Probable lipase LipE 0.0029 0.0084 0.0651
Brugia malayi hypothetical protein 0.0017 0.0005 0.0029
Entamoeba histolytica vacuolar protein sorting 26 0.0093 0.0491 0.3043
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0093 0.0491 0.0822
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0053 0.0053
Brugia malayi aspartic protease BmAsp-2, identical 0.0017 0.0005 0.0029
Mycobacterium tuberculosis Probable lipase LipD 0.0029 0.0084 0.0651
Brugia malayi aspartic protease BmAsp-1, identical 0.0017 0.0005 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.028 0.2901
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0053 0.0089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0264 0.1583 1
Brugia malayi Dopamine receptor 0.0024 0.0053 0.0296
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0077 0.0688
Plasmodium vivax aspartyl proteinase, putative 0.0071 0.0352 0.3749
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0071 0.0352 0.0589
Trypanosoma cruzi Aph-1 protein, putative 0.0115 0.0635 0.6768
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0005 0.0009
Onchocerca volvulus 0.0297 0.1795 1
Schistosoma mansoni gamma-secretase subunit aph-1 0.0296 0.1789 0.2993
Echinococcus granulosus importin subunit beta 1 0.0028 0.0077 0.0077
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0033 0.0108 0.0599
Onchocerca volvulus 0.0037 0.0136 0.0731
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0053 0.0089
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Leishmania major glycerol uptake protein, putative 0.0093 0.0491 0.5208
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0118 0.0652 0.0652
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0033 0.0108 0.0108
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0053 0.0089
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Schistosoma mansoni biogenic amine receptor 0.0024 0.0053 0.0089
Echinococcus multilocularis sterol O acyltransferase 1 0.0951 0.5977 0.5977
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0053 0.0053
Brugia malayi MBOAT family protein 0.0093 0.0491 0.2737
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.028 0.2901
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0029 0.0084 0.0651
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0033 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Schistosoma mansoni amine GPCR 0.0024 0.0053 0.0089
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0053 0.0089
Plasmodium vivax DNA topoisomerase II, putative 0.0033 0.0108 0.1112
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0033 0.0108 0.0875
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.028 0.2901
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0053 0.0089
Plasmodium falciparum plasmepsin IV 0.0071 0.0352 0.3749
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0118 0.0652 0.0652
Schistosoma mansoni amine GPCR 0.0024 0.0053 0.0089
Plasmodium vivax endoplasmin, putative 0.0162 0.0931 1
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0093 0.0491 0.0491
Onchocerca volvulus 0.0021 0.0034 0.0163
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0053 0.0089
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0053 0.0089
Mycobacterium ulcerans lipase LipD 0.0029 0.0084 0.099
Schistosoma mansoni opsin-like receptor 0.0024 0.0053 0.0089
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0077 0.0688
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0181
Schistosoma mansoni zinc finger protein 0.0016 0.0002 0.0004
Toxoplasma gondii heat shock protein 90, putative 0.0162 0.0931 0.0971
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0264 0.1583 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Trypanosoma brucei heat shock protein, putative 0.0162 0.0931 1
Onchocerca volvulus 0.0021 0.0034 0.0163
Trypanosoma brucei heat shock protein, putative 0.0162 0.0931 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0084 0.0141
Mycobacterium ulcerans beta-lactamase 0.0029 0.0084 0.099
Echinococcus granulosus neuropeptide s receptor 0.0024 0.0053 0.0053
Brugia malayi Hsp90 protein 0.0066 0.0321 0.1788
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0264 0.1583 1
Schistosoma mansoni hypothetical protein 0.0031 0.0096 0.0161
Brugia malayi hypothetical protein 0.0024 0.0053 0.0296
Plasmodium falciparum endoplasmin, putative 0.0099 0.0531 0.5685
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0264 0.1583 1
Brugia malayi RNA, U transporter 1 0.008 0.0408 0.2272
Brugia malayi putative neuropeptide receptor 0.0024 0.0053 0.0296
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.003 0.009 0.009
Schistosoma mansoni biogenic amine receptor 0.0024 0.0053 0.0089
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0093 0.0491 0.3043
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0093 0.0491 0.0491
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0525 0.0878
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0009
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.003 0.005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0053 0.0053
Schistosoma mansoni neuropeptide receptor 0.0024 0.0053 0.0089
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0053 0.0053
Schistosoma mansoni zinc finger protein 0.0093 0.0491 0.0822
Echinococcus granulosus heat shock protein 90 0.0162 0.0931 0.0931
Trypanosoma brucei heat shock protein, putative 0.0162 0.0931 1
Brugia malayi hypothetical protein 0.0017 0.0005 0.0029
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0071 0.0352 0.2155
Echinococcus multilocularis gamma secretase subunit aph 1 0.0296 0.1789 0.1789
Trypanosoma cruzi glycerol uptake protein, putative 0.0093 0.0491 0.5208
Loa Loa (eye worm) aspartyl protease 6 0.0017 0.0005 0.0009
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0029 0.0084 0.0651
Toxoplasma gondii heat shock protein 75, putative 0.0066 0.0321 0.0331
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.003 0.0266
Loa Loa (eye worm) hhat protein 0.0093 0.0491 0.0822
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0053 0.0089
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0033 0.0108 0.0575
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0053 0.0089
Loa Loa (eye worm) hypothetical protein 0.0028 0.0077 0.0129
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0077 0.0075
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0129 0.0721 0.658
Trypanosoma cruzi heat shock protein 90, putative 0.0162 0.0931 1
Echinococcus granulosus g protein coupled receptor 0.0024 0.0053 0.0053
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0033 0.0108 0.0599
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0071 0.0352 0.0364
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0053 0.0053
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0053 0.0053
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0033 0.0108 0.0602
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0129 0.072 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0053 0.0053
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0093 0.0491 0.5254
Onchocerca volvulus 0.0024 0.0053 0.0268
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0053 0.0089
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0053 0.0268
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.003 0.0166
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0053 0.0053
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0005 0.0009
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0093 0.0491 0.3043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.028 0.2901
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0053 0.0053
Giardia lamblia Fructose-bisphosphate aldolase 0.0264 0.1583 1
Onchocerca volvulus 0.0024 0.0053 0.0268
Toxoplasma gondii Hsp90 domain-containing protein 0.0066 0.0321 0.0331
Entamoeba histolytica Ran family GTPase 0.0021 0.003 0.01
Onchocerca volvulus 0.0024 0.0053 0.0268
Echinococcus multilocularis serotonin receptor 0.0024 0.0053 0.0053
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.1813 0.3034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.028 0.2901
Brugia malayi Probable DNA topoisomerase II 0.0033 0.0108 0.0602
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0053 0.0053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0053 0.0053
Trypanosoma cruzi heat shock protein 85, putative 0.0162 0.0931 1
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0037 0.0136 0.0758
Trichomonas vaginalis receptor histidine kinase, putative 0.0033 0.0108 0.0599
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0129 0.072 0.7705
Brugia malayi Hhat protein 0.0093 0.0491 0.2737
Schistosoma mansoni cathepsin D (A01 family) 0.0071 0.0352 0.0589
Brugia malayi hypothetical protein 0.0297 0.1795 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0014 0.0097
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0053 0.0053
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0525 0.2922
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Brugia malayi Bromodomain containing protein 0.0032 0.0102 0.057
Onchocerca volvulus 0.0024 0.0053 0.0268
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0017 0.0005 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0491 0.3043
Plasmodium vivax plasmepsin IV, putative 0.0071 0.0352 0.3749
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Trypanosoma cruzi heat shock protein 85, putative 0.0129 0.072 0.7705
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0084 0.0141
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.005 0.0217 0.0217
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0129 0.0721 1
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0491 0.3043
Onchocerca volvulus 0.0024 0.0053 0.0268
Echinococcus granulosus tumor protein p63 0.0317 0.1922 0.1922
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0029 0.0084 0.0651
Loa Loa (eye worm) hypothetical protein 0.0029 0.0084 0.0141
Brugia malayi MH2 domain containing protein 0.0235 0.1399 0.7793
Mycobacterium ulcerans two component regulator - sensor kinase 0.0033 0.0108 0.133
Plasmodium falciparum heat shock protein 90 0.0162 0.0931 1
Plasmodium falciparum plasmepsin II 0.0071 0.0352 0.3749
Brugia malayi heat shock protein 90 0.0162 0.0931 0.5184
Echinococcus multilocularis snurportin 1 0.03 0.1813 0.1813
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0053 0.0089
Onchocerca volvulus 0.0024 0.0053 0.0268
Schistosoma mansoni endoplasmin 0.0162 0.0931 0.1557
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.003 0.003
Echinococcus granulosus fetal alzheimer antigen falz 0.0019 0.0018 0.0018
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0053 0.0089
Loa Loa (eye worm) endoplasmin 0.0162 0.0931 0.1557
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0096 0.0096
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0053 0.0089
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0077 0.0077
Echinococcus multilocularis sex peptide receptor 0.0024 0.0053 0.0053
Leishmania major importin beta-1 subunit, putative 0.0023 0.0043 0.0317
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0093 0.0491 0.5254
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0181
Brugia malayi Pepsin A precursor 0.0017 0.0005 0.0029
Brugia malayi Melatonin receptor type 1A 0.0024 0.0053 0.0296
Loa Loa (eye worm) heat shock protein 75 0.0066 0.0321 0.0537
Plasmodium vivax heat shock protein, putative 0.0066 0.0321 0.3412
Trypanosoma brucei heat shock protein, putative 0.0162 0.0931 1
Mycobacterium tuberculosis Conserved protein 0.0033 0.0108 0.0875
Schistosoma mansoni hypothetical protein 0.0024 0.0053 0.0089
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0053 0.0053
Trypanosoma brucei glycerol uptake protein, putative 0.0093 0.0491 0.5208
Echinococcus granulosus o acyltransferase membrane bound domain 0.0093 0.0491 0.0491
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0029 0.0084 0.0468
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0071 0.0352 0.0352
Trichomonas vaginalis receptor histidine kinase, putative 0.0033 0.0108 0.0599
Schistosoma mansoni hypothetical protein 0.0031 0.0096 0.0161
Schistosoma mansoni heat shock protein 0.0162 0.0931 0.1557
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0024 0.0053 0.0053
Onchocerca volvulus 0.0024 0.0053 0.0268
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0084 0.0763
Schistosoma mansoni adenoreceptor 0.0024 0.0053 0.0089
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0096 0.0096
Schistosoma mansoni neuropeptide receptor 0.0024 0.0053 0.0089
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0053 0.0053
Trypanosoma brucei heat shock protein, putative 0.0162 0.0931 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0053 0.0089
Echinococcus multilocularis heat shock protein 90 0.0162 0.0931 0.0931
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Trypanosoma cruzi glycerol uptake protein, putative 0.0093 0.0491 0.5208
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0037 0.0136 0.0758
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0093 0.0491 0.0491
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0009
Echinococcus multilocularis GPCR, family 2 0.0031 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0093 0.0491 0.0822
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0021 0.0034 0.0191
Trypanosoma cruzi heat shock protein 90, putative 0.0095 0.0507 0.5382
Echinococcus granulosus somatostatin receptor 0.0024 0.0053 0.0053
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0084 0.0141
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.021
Plasmodium falciparum importin beta, putative 0.0028 0.0077 0.0778
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0053 0.0053
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0024 0.0053 0.0089
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0033 0.0108 0.0875
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0093 0.0491 0.0491
Leishmania major DNA topoisomerase ii 0.0033 0.0108 0.1025
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0053 0.0089
Trypanosoma cruzi GUP1, putative 0.0093 0.0491 0.5208
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0053 0.0053
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0033 0.0108 0.133
Onchocerca volvulus 0.0024 0.0053 0.0268
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0084 0.0446
Loa Loa (eye worm) MBOAT family protein 0.0093 0.0491 0.0822
Brugia malayi Cytochrome P450 family protein 0.0022 0.0038 0.021
Entamoeba histolytica heat shock protein 90, putative 0.0162 0.0931 0.5844
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0118 0.0652 0.1091
Schistosoma mansoni endoplasmin 0.0162 0.0931 0.1557
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Echinococcus granulosus allatostatin A receptor 0.0024 0.0053 0.0053
Trypanosoma cruzi Heat shock protein 83, putative 0.0162 0.0931 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0053 0.0053
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0033 0.0108 0.0875
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0053 0.0053
Trypanosoma brucei Aph-1 protein, putative 0.0115 0.0635 0.6768
Loa Loa (eye worm) hypothetical protein 0.0029 0.0084 0.0141
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0014 0.0014
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0071 0.0352 0.0589
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0033 0.0108 0.1025
Trypanosoma cruzi DNA topoisomerase II, putative 0.0033 0.0108 0.1025
Trichomonas vaginalis heat shock protein, putative 0.0129 0.072 0.4502
Brugia malayi Bromodomain containing protein 0.0063 0.0299 0.1663
Trypanosoma brucei heat shock protein, putative 0.0162 0.0931 1
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0066 0.0321 0.1764
Brugia malayi GnHR receptor homolog 0.0024 0.0053 0.0296
Onchocerca volvulus 0.0024 0.0053 0.0268
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.006 0.028 0.2901
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Mycobacterium tuberculosis Possible two component sensor kinase 0.0033 0.0108 0.0875
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0093 0.0491 0.0491
Treponema pallidum fructose-bisphosphate aldolase 0.0264 0.1583 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.003 0.0171
Trichomonas vaginalis heat shock protein, putative 0.0162 0.0931 0.5844
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0093 0.0491 0.0491
Brugia malayi hypothetical protein 0.0024 0.0053 0.0296
Leishmania major heat shock protein 83-1 0.0162 0.0931 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0162 0.0931 0.5844
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0053 0.0089
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0089
Brugia malayi hypothetical protein 0.0021 0.0034 0.0191
Onchocerca volvulus 0.0037 0.0136 0.0731
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0071 0.0352 0.0352
Brugia malayi hypothetical protein 0.0024 0.0053 0.0296
Trypanosoma brucei heat shock protein, putative 0.0162 0.0931 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1000 nM Modulation of gamma-secretase (unknown origin) assessed as inhibition of amyloid beta 42 production ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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