Detailed information for compound 1857965

Basic information

Technical information
  • TDR Targets ID: 1857965
  • Name: 3-chloro-N-[(6-methylpyridin-2-yl)methylidene amino]benzamide
  • MW: 273.718 | Formula: C14H12ClN3O
  • H donors: 1 H acceptors: 2 LogP: 3.12 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(n1)/C=N/NC(=O)c1cccc(c1)Cl
  • InChi: 1S/C14H12ClN3O/c1-10-4-2-7-13(17-10)9-16-18-14(19)11-5-3-6-12(15)8-11/h2-9H,1H3,(H,18,19)/b16-9+
  • InChiKey: ZZOFMZRSKDHXJI-CXUHLZMHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-chloro-N-[(6-methyl-2-pyridyl)methyleneamino]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens angiotensin II receptor, type 1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Mus musculus transient receptor potential cation channel, subfamily C, member 4 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus TRP transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma mansoni transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis TRP (transient receptor potential) channel Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma mansoni transient receptor potential channel 4 Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum Transient receptor potential-gamma protein, putative Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Brugia malayi Transient-receptor-potential like protein Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyroglutamylated rfamide peptide receptor angiotensin II receptor, type 1 359 aa 403 aa 19.1 %
Echinococcus multilocularis short transient receptor potential channel 6 transient receptor potential cation channel, subfamily C, member 4 890 aa 799 aa 31.2 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis disco interacting protein 2 0.0021 0.0032 0.0064
Leishmania major udp-glc 4-epimerase, putative 0.0042 0.0103 0.0155
Trypanosoma cruzi heat shock protein 85, putative 0.0215 0.0692 0.1037
Trichomonas vaginalis receptor histidine kinase, putative 0.0121 0.037 0.1119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0001 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0407 0.1344 0.4065
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0263 0.0856 0.2587
Brugia malayi hypothetical protein 0.018 0.0571 0.1728
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0001 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0015 0.0022
Leishmania major hypothetical protein, conserved 0.0121 0.037 0.0555
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0121 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0055 0.0147 0.0444
Echinococcus multilocularis carbonic anhydrase 0.0369 0.1215 0.2452
Onchocerca volvulus 0.0038 0.0088 0.0278
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0044 0.0109 0.0211
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.008 0.0233 0.0706
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0014 0.0014
Echinococcus multilocularis carbonic anhydrase II 0.0497 0.1652 0.3334
Trypanosoma brucei heat shock protein 90, putative 0.0215 0.0692 0.1037
Echinococcus multilocularis muscleblind protein 0.0064 0.0178 0.0359
Trypanosoma brucei unspecified product 0.0023 0.0039 0.0059
Schistosoma mansoni carbonic anhydrase-related 0.0369 0.1215 0.2353
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0001 0.0002
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0121 0.037 0.037
Schistosoma mansoni carbonic anhydrase 0.0369 0.1215 0.2353
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0079 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0841 0.2822 0.8534
Leishmania major DNA polymerase eta, putative 0.0021 0.0032 0.0048
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0019 0.0057
Loa Loa (eye worm) hypothetical protein 0.0025 0.0046 0.014
Brugia malayi UDP galactose 4'-epimerase 0.004 0.0097 0.0295
Brugia malayi Thioredoxin reductase 0.0034 0.0077 0.0233
Loa Loa (eye worm) hypothetical protein 0.0064 0.0178 0.0539
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0085 0.017
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0121 0.037 0.0747
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0085 0.0255
Brugia malayi glutathione reductase 0.0034 0.0077 0.0233
Giardia lamblia DNA topoisomerase III 0.0212 0.068 0.2348
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0043
Onchocerca volvulus 0.0016 0.0014 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0059
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.0068 0.0205
Echinococcus granulosus neuropeptide s receptor 0.0191 0.0608 0.1838
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0044 0.0109 0.022
Trichomonas vaginalis glutaminase, putative 0.0272 0.0886 0.2679
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) 0.2051 0.694 0.694
Trypanosoma cruzi cruzipain precursor, putative 0.0028 0.0056 0.0085
Loa Loa (eye worm) glutaminase 2 0.0272 0.0886 0.2679
Mycobacterium tuberculosis Probable lipase LipD 0.0016 0.0014 0.0014
Echinococcus granulosus heat shock protein 90 0.0215 0.0692 0.209
Echinococcus multilocularis lysosomal alpha glucosidase 0.0143 0.0447 0.0903
Trypanosoma brucei carbonic anhydrase-like protein 0.0497 0.1652 0.2476
Echinococcus multilocularis muscleblind protein 1 0.0064 0.0178 0.0359
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0016 0.0014 0.0027
Brugia malayi beta-lactamase 0.0016 0.0014 0.0043
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0016 0.0014 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0015 0.0022
Trichomonas vaginalis penicillin-binding protein, putative 0.0016 0.0014 0.0043
Echinococcus granulosus thioredoxin glutathione reductase 0.0034 0.0077 0.0232
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0001 0.0002
Plasmodium vivax importin-beta 2, putative 0.0021 0.0033 0.0032
Entamoeba histolytica heat shock protein 90, putative 0.0215 0.0692 0.2091
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0121 0.037 0.0555
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0369 0.1215 0.3673
Trypanosoma cruzi heat shock protein 90, putative 0.0166 0.0526 0.0789
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0039 0.0059
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0094 0.0281 0.0385
Loa Loa (eye worm) hypothetical protein 0.018 0.0571 0.1728
Echinococcus multilocularis snurportin 1 0.0229 0.0739 0.1491
Giardia lamblia Grp94/Hsp90 0.0094 0.0281 0.0969
Trypanosoma cruzi heat shock protein 90, putative 0.0094 0.0281 0.0421
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0012 0 0.0001
Trichomonas vaginalis maltase-glucoamylase, putative 0.0032 0.0068 0.0205
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0121 0.037 0.0629
Trypanosoma brucei heat shock protein, putative 0.0215 0.0692 0.1037
Trypanosoma brucei developmentally regulated phosphoprotein 0.0121 0.037 0.0555
Toxoplasma gondii DNA topoisomerase family protein 0.0212 0.068 0.1156
Toxoplasma gondii UDP-glucose 4-epimerase 0.004 0.0097 0.0165
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0001 0.0004
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0021 0.0032 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0088 0.017
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0121 0.037 0.037
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0029 0.006 0.018
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0039 0.0059
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0016 0.0014 0.0014
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0121 0.037 0.037
Trichomonas vaginalis sensor histidine kinase, putative 0.0121 0.037 0.1119
Loa Loa (eye worm) DNA topoisomerase III 0.0212 0.068 0.2057
Echinococcus granulosus heat shock protein 0.0215 0.0692 0.209
Plasmodium vivax SET domain protein, putative 0.0038 0.0088 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0059
Brugia malayi RNA, U transporter 1 0.0061 0.0167 0.0506
Schistosoma mansoni ran 0.0016 0.0013 0.0025
Mycobacterium tuberculosis Conserved protein 0.0016 0.0014 0.0014
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0212 0.068 0.1318
Echinococcus granulosus TRP transient receptor potential channel 0.0044 0.0108 0.0326
Echinococcus multilocularis heat shock protein 90 0.0094 0.0281 0.0567
Loa Loa (eye worm) hypothetical protein 0.018 0.0571 0.1728
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0001 0.0002
Brugia malayi nuclear hormone receptor 0.0012 0.0001 0.0004
Trichomonas vaginalis glutathione reductase, putative 0.0012 0 0.0001
Chlamydia trachomatis DNA gyrase subunit B 0.1962 0.6637 0.6637
Plasmodium falciparum glutathione reductase 0.0034 0.0077 0.0077
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0121 0.037 0.037
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0087 0.0257 0.0257
Trypanosoma cruzi DNA topoisomerase III, putative 0.0212 0.068 0.102
Plasmodium falciparum DNA gyrase subunit A 0.1612 0.5447 0.5447
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0087 0.0257 0.0257
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0031 0.0065 0.0131
Schistosoma mansoni alpha-glucosidase 0.0123 0.038 0.0735
Echinococcus multilocularis thioredoxin glutathione reductase 0.0034 0.0077 0.0155
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0369 0.1215 0.3673
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0032 0.0068 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0002
Plasmodium falciparum importin beta, putative 0.0021 0.0033 0.0032
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0029 0.006 0.0115
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0032 0.0048
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0001 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0059
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0001 0.0004
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0943 0.317 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0016 0.0014 0.0027
Echinococcus multilocularis carbonic anhydrase 0.0369 0.1215 0.2452
Schistosoma mansoni ran 0.0016 0.0013 0.0025
Trypanosoma cruzi DNA topoisomerase III, putative 0.0212 0.068 0.102
Loa Loa (eye worm) runx1 0.0023 0.0036 0.011
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0025 0.0046 0.0089
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Schistosoma mansoni intermediate filament proteins 0.0012 0.0001 0.0001
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0121 0.037 0.0629
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0001 0.0003
Trypanosoma brucei DNA topoisomerase IA, putative 0.0212 0.068 0.102
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0212 0.068 0.1318
Chlamydia trachomatis DNA gyrase subunit A 0.1612 0.5447 0.5447
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0121 0.037 0.1118
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.0054
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 0.2051 0.694 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0016 0.0013 0.0045
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0039 0.0079
Echinococcus multilocularis microtubule associated protein 2 0.028 0.0913 0.1842
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0038 0.0088 0.0149
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbA 0.2051 0.694 0.694
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0121 0.037 0.0555
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0044 0.0109 0.0211
Leishmania major DNA topoisomerase III, putative 0.0212 0.068 0.102
Mycobacterium ulcerans DNA gyrase subunit A 0.1612 0.5447 0.5447
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbC 0.2051 0.694 0.694
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0039 0.0059
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0025 0.0046 0.014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0038 0.0088 0.0177
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0039 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0056 0.0085
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0025 0.0046 0.0093
Trypanosoma cruzi UDP-galactose 4-epimerase 0.004 0.0097 0.0146
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0079 0.0227 0.0227
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0087 0.0263
Trypanosoma brucei DNA polymerase eta, putative 0.0037 0.0087 0.0131
Echinococcus granulosus lamin dm0 0.0012 0.0001 0.0001
Schistosoma mansoni coup transcription factor 0.0012 0.0001 0.0002
Schistosoma mansoni lozenge 0.0023 0.0036 0.007
Loa Loa (eye worm) hypothetical protein 0.0249 0.0807 0.244
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.004 0.0097 0.0295
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0868 0.2625
Mycobacterium ulcerans putative regultory protein 0.0121 0.037 0.037
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0087 0.0131
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0016 0.0014 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0014 0.0021
Trichomonas vaginalis DNA topoisomerase II, putative 0.0983 0.3307 1
Plasmodium vivax endoplasmin, putative 0.0215 0.0692 0.0691
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0059
Schistosoma mansoni alpha glucosidase 0.0032 0.0068 0.0131
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0868 0.2625
Trichomonas vaginalis D-aminoacylase, putative 0.0016 0.0014 0.0043
Echinococcus multilocularis neuropeptide s receptor 0.0191 0.0608 0.1227
Loa Loa (eye worm) hypothetical protein 0.0074 0.021 0.0636
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.1612 0.5447 0.5447
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0001 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0001 0.0004
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 0.2051 0.694 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0079 0.0227 0.0307
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0016 0.0014 0.0014
Trichomonas vaginalis endoplasmin, putative 0.0169 0.0536 0.1619
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0121 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0004
Echinococcus multilocularis musashi 0.0012 0.0001 0.0001
Echinococcus multilocularis UDP glucose 4 epimerase 0.004 0.0097 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0059
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0087 0.0257 0.035
Trypanosoma cruzi heat shock protein 90, putative 0.0215 0.0692 0.1037
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0001 0.0004
Brugia malayi latrophilin 2 splice variant baaae 0.0055 0.0147 0.0444
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.0905 0.1754
Schistosoma mansoni carbonic anhydrase-related 0.0369 0.1215 0.2353
Brugia malayi hypothetical protein 0.0045 0.0112 0.0338
Onchocerca volvulus 0.0083 0.0242 0.0763
Echinococcus multilocularis carbonic anhydrase 0.0369 0.1215 0.2452
Loa Loa (eye worm) glutathione reductase 0.0034 0.0077 0.0233
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0116 0.0354 0.0354
Treponema pallidum DNA topoisomerase I (topA) 0.0212 0.068 0.068
Schistosoma mansoni hypothetical protein 0.0025 0.0046 0.0089
Mycobacterium ulcerans two component regulator - sensor kinase 0.0121 0.037 0.037
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.0068 0.0205
Treponema pallidum hypothetical protein 0.0116 0.0354 0.0354
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Schistosoma mansoni glutaminase 0.0272 0.0886 0.1716
Trichomonas vaginalis heat shock protein, putative 0.0094 0.0281 0.085
Leishmania major carbonic anhydrase-like protein 0.0497 0.1652 0.2476
Loa Loa (eye worm) glutaminase 0.0272 0.0886 0.2679
Mycobacterium tuberculosis Conserved protein 0.0016 0.0014 0.0014
Entamoeba histolytica heat shock protein 90, putative 0.0215 0.0692 0.2091
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0021 0.0032 0.0061
Schistosoma mansoni pyruvate dehydrogenase 0.0121 0.037 0.0717
Trichomonas vaginalis heat shock protein, putative 0.0094 0.0281 0.085
Trichomonas vaginalis heat shock protein, putative 0.0049 0.0125 0.0378
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0121 0.037 0.037
Schistosoma mansoni endoplasmin 0.0215 0.0692 0.134
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0039 0.0119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0088 0.017
Trichomonas vaginalis glucosylceramidase, putative 0.0407 0.1344 0.4065
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0943 0.317 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0032 0.0068 0.0205
Echinococcus granulosus carbonic anhydrase 0.0369 0.1215 0.3673
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0004
Echinococcus multilocularis lamin dm0 0.0012 0.0001 0.0001
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0049 0.0125 0.0252
Brugia malayi Probable DNA topoisomerase II 0.0983 0.3307 1
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0756 0.2532 0.3636
Leishmania major importin beta-1 subunit, putative 0.0017 0.0019 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0088 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0056 0.0085
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0019 0.0057
Mycobacterium ulcerans DNA topoisomerase I 0.0212 0.068 0.068
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0013 0.0005 0.0007
Toxoplasma gondii peptidylprolyl isomerase 0.0013 0.0005 0.0008
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.0068 0.0205
Echinococcus granulosus muscleblind protein 0.0064 0.0178 0.0538
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0121 0.037 0.037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0039 0.0059
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.0054
Trypanosoma brucei DNA topoisomerase ii 0.1971 0.667 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0121 0.037 0.1119
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0068 0.0205
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0068 0.0205
Schistosoma mansoni lamin 0.0012 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0015 0.0022
Loa Loa (eye worm) carbonic anhydrase 3 0.0497 0.1652 0.4994
Trypanosoma brucei unspecified product 0.0016 0.0015 0.0022
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Echinococcus granulosus importin subunit beta 1 0.0021 0.0033 0.0098
Trypanosoma brucei glucosidase, putative 0.0032 0.0068 0.0102
Loa Loa (eye worm) beta-lactamase 0.0016 0.0014 0.0043
Schistosoma mansoni hypothetical protein 0.0031 0.0065 0.0126
Trypanosoma brucei heat shock protein 84, putative 0.0049 0.0125 0.0188
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0025 0.0046 0.0139
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0267
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0121 0.037 0.037
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0034 0.0077 0.0077
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0001 0.0002
Brugia malayi intermediate filament protein 0.0012 0.0001 0.0002
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0026 0.0048 0.0072
Entamoeba histolytica DNA topoisomerase III, putative 0.0212 0.068 0.2057
Echinococcus multilocularis neuropeptide receptor A26 0.0191 0.0608 0.1227
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0014 0.0021
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0001 0.0004
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.295 1 1
Loa Loa (eye worm) heat shock protein 90 0.0215 0.0692 0.2091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0056 0.0085
Loa Loa (eye worm) hypothetical protein 0.0121 0.037 0.1119
Loa Loa (eye worm) hypothetical protein 0.004 0.0095 0.0287
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0039 0.0059
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0983 0.3307 0.6676
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0116 0.0354 0.0354
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.295 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0056 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0001 0.0004
Giardia lamblia Pms1-like protein 0.0121 0.037 0.1277
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.0068 0.0205
Trypanosoma cruzi PAB1-binding protein , putative 0.0069 0.0195 0.0293
Leishmania major alpha glucosidase II subunit, putative 0.0032 0.0068 0.0102
Plasmodium vivax DNA gyrase subunit A, putative 0.1612 0.5447 0.5447
Leishmania major DNA topoisomerase ii 0.0772 0.2587 0.3878
Plasmodium vivax heat shock protein 86, putative 0.0215 0.0692 0.0691
Trichomonas vaginalis D-aminoacylase, putative 0.0016 0.0014 0.0043
Brugia malayi Pre-SET motif family protein 0.0038 0.0088 0.0267
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0121 0.037 0.037
Schistosoma mansoni lamin 0.0012 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0369 0.1215 0.2353
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0212 0.068 0.068
Loa Loa (eye worm) hypothetical protein 0.0249 0.0807 0.244
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0014 0.0006 0.0018
Giardia lamblia DINP protein human, muc B family 0.0023 0.0039 0.0135
Giardia lamblia UDP-glucose 4-epimerase 0.0042 0.0103 0.0355
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0079 0.0227 0.0227
Echinococcus granulosus endoplasmin 0.0094 0.0281 0.0849
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0004
Echinococcus multilocularis importin subunit beta 1 0.0021 0.0033 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0001 0.0004
Trichomonas vaginalis UDP-glucose 4-epimerase, putative 0.004 0.0097 0.0295
Echinococcus multilocularis neutral alpha glucosidase AB 0.0032 0.0068 0.0137
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0001 0.0002
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0983 0.3307 1
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.0917 0.2773
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0001 0.0004
Echinococcus granulosus GTP binding nuclear protein Ran 0.0016 0.0013 0.004
Plasmodium falciparum carbonic anhydrase 0.0369 0.1215 0.1215
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0212 0.068 0.0962
Echinococcus granulosus cpg binding protein 0.0018 0.0022 0.0067
Brugia malayi nuclear receptor NHR-88 0.0012 0.0001 0.0004
Echinococcus multilocularis heat shock protein 0.0215 0.0692 0.1396
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0044 0.0109 0.0211
Mycobacterium tuberculosis Conserved protein 0.0016 0.0014 0.0014
Echinococcus multilocularis Protein lozenge 0.0023 0.0036 0.0073
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0103 0.0309 0.0308
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0044 0.0109 0.0211
Mycobacterium tuberculosis Probable lipase LipE 0.0016 0.0014 0.0014
Echinococcus granulosus expressed protein 0.0014 0.0006 0.0017
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0047 0.0118 0.0118
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0001 0.0002
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0094 0.0281 0.0281
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0016 0.0014 0.0043
Schistosoma mansoni DNA polymerase eta 0.0037 0.0087 0.0168
Plasmodium vivax ataxin-2 like protein, putative 0.0069 0.0195 0.0195
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0044 0.0109 0.033
Brugia malayi ecdysteroid receptor 0.0012 0.0001 0.0004
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0121 0.037 0.037
Leishmania major cathepsin L-like protease 0.0028 0.0056 0.0085
Trichomonas vaginalis rotamase, putative 0.0014 0.0006 0.0018
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0497 0.1652 0.32
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0121 0.037 0.1119
Mycobacterium ulcerans esterase/lipase LipP 0.0016 0.0014 0.0014
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0121 0.037 0.1119
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0049 0.0125 0.0378
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0064 0.0178 0.0539
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0085 0.0164
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0016 0.0013 0.002
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0039 0.0079
Loa Loa (eye worm) hypothetical protein 0.0029 0.006 0.018
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0983 0.3307 1
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0056 0.0085
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0036 0.0083 0.0251
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0014 0.0006 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0001 0.0004
Echinococcus granulosus snurportin 1 0.0229 0.0739 0.2233
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.0263
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0212 0.068 0.2056
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0068 0.0102
Brugia malayi steroid hormone receptor 0.0012 0.0001 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0001 0.0004
Trypanosoma brucei unspecified product 0.0016 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0043
Toxoplasma gondii heat shock protein 90, putative 0.0215 0.0692 0.1175
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0043
Mycobacterium tuberculosis Probable hydrolase 0.0016 0.0014 0.0014
Trypanosoma cruzi heat shock protein, putative 0.0049 0.0125 0.0188
Schistosoma mansoni hypothetical protein 0.0796 0.2668 0.5169
Schistosoma mansoni importin beta-1 0.0021 0.0033 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0085 0.0164
Toxoplasma gondii heat shock protein 75, putative 0.0049 0.0125 0.0212
Mycobacterium leprae Probable two-component sensor kinase 0.0121 0.037 0.0514
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0001 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0059
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0025 0.0046 0.0139
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0212 0.068 0.102
Loa Loa (eye worm) hypothetical protein 0.054 0.1797 0.5435
Schistosoma mansoni transient receptor potential channel 0.0117 0.0359 0.0694
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0121 0.037 0.1119
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0121 0.037 0.037
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0121 0.037 0.037
Onchocerca volvulus 0.03 0.0979 0.309
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0049 0.0125 0.0377
Mycobacterium ulcerans two component sensor kinase MprB 0.0121 0.037 0.037
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0068 0.0205
Trichomonas vaginalis set domain proteins, putative 0.03 0.0979 0.2961
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0013 0.0005 0.0014
Toxoplasma gondii ABC1 family protein 0.0016 0.0014 0.0024
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0001 0.0003
Brugia malayi Muscleblind-like protein 0.0064 0.0178 0.0539
Brugia malayi GRF zinc finger family protein 0.0212 0.068 0.2057
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0369 0.1215 0.3673
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Chlamydia trachomatis DNA topoisomerase I 0.0212 0.068 0.068
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0212 0.068 0.102
Loa Loa (eye worm) latrophilin receptor protein 2 0.0025 0.0046 0.014
Mycobacterium tuberculosis Conserved protein 0.0121 0.037 0.037
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0068 0.0205
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0016 0.0013 0.0013
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0025 0.0046 0.0093
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0001 0.0003
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0369 0.1215 0.3673
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0013 0.0005 0.0007
Plasmodium falciparum heat shock protein 90, putative 0.0049 0.0125 0.0125
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0121 0.037 0.0514
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0056 0.0085
Toxoplasma gondii hypothetical protein 0.0047 0.0118 0.02
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Onchocerca volvulus 0.0012 0.0001 0.0004
Onchocerca volvulus 0.018 0.0571 0.1803
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0037 0.0085 0.0256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0056 0.0085
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0369 0.1215 0.3673
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0016 0.0013 0.0026
Brugia malayi beta-lactamase family protein 0.0016 0.0014 0.0043
Trypanosoma cruzi PAB1-binding protein , putative 0.0069 0.0195 0.0293
Echinococcus granulosus GPCR family 2 0.0025 0.0046 0.0139
Echinococcus granulosus dna polymerase kappa 0.0023 0.0039 0.0118
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0094 0.0281 0.0421
Echinococcus granulosus carbonic anhydrase 0.0369 0.1215 0.3673
Leishmania major cathepsin L-like protease 0.0028 0.0056 0.0085
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0031 0.0065 0.0197
Mycobacterium ulcerans glutaminase 0.0272 0.0886 0.0886
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0116 0.0354 0.049
Echinococcus multilocularis beta LACTamase domain containing family member 0.0016 0.0014 0.0028
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0039 0.0059
Loa Loa (eye worm) hypothetical protein 0.0069 0.0195 0.059
Plasmodium falciparum DNA gyrase subunit B 0.295 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0077 0.0115
Leishmania major DNA topoisomerase III, putative 0.0212 0.068 0.102
Trichomonas vaginalis ran, putative 0.0016 0.0013 0.0041
Entamoeba histolytica UDP-glucose 4-epimerase, putative 0.004 0.0097 0.0295
Schistosoma mansoni hypothetical protein 0.0025 0.0046 0.0089
Trichomonas vaginalis importin beta-1, putative 0.0017 0.0019 0.0057
Schistosoma mansoni cpg binding protein 0.0018 0.0022 0.0043
Echinococcus multilocularis lamin 0.0012 0.0001 0.0001
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0039 0.0059
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0056 0.0085
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0121 0.037 0.037
Plasmodium falciparum thioredoxin reductase 0.0034 0.0077 0.0077
Trichomonas vaginalis glucosylceramidase, putative 0.0407 0.1344 0.4065
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0121 0.037 0.037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0001 0.0004
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0983 0.3307 1
Loa Loa (eye worm) hypothetical protein 0.0369 0.1215 0.3673
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0059
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Mycobacterium ulcerans heat shock protein 90 0.0094 0.0281 0.0281
Brugia malayi Melibiase family protein 0.0029 0.006 0.018
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0039 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0085 0.0164
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.1005 0.3381 0.4861
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0001 0.0004
Plasmodium vivax DNA topoisomerase 3, putative 0.0212 0.068 0.068
Brugia malayi DNA topoisomerase III beta-1 0.0212 0.068 0.2057
Giardia lamblia Heat shock protein HSP 90-alpha 0.0215 0.0692 0.2387
Echinococcus granulosus UDP glucose 4 epimerase 0.004 0.0097 0.0294
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0001 0.0004
Echinococcus granulosus microtubule associated protein 2 0.028 0.0913 0.2759
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0772 0.2587 0.3878
Mycobacterium ulcerans lipase LipD 0.0016 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0043
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0032 0.0068 0.0205
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0497 0.1652 0.4994
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0085 0.017
Plasmodium falciparum endoplasmin, putative 0.0169 0.0536 0.0535
Schistosoma mansoni hypothetical protein 0.0055 0.0147 0.0284
Schistosoma mansoni rotamase 0.0014 0.0006 0.0011
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbB 0.2051 0.694 0.694
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0016 0.0014 0.0014
Toxoplasma gondii HEAT repeat-containing protein 0.0021 0.0033 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0001 0.0004
Echinococcus multilocularis endoplasmin 0.0094 0.0281 0.0567
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) 0.2051 0.694 1
Echinococcus multilocularis expressed protein 0.0014 0.0006 0.0011
Trypanosoma brucei heat shock protein, putative 0.0215 0.0692 0.1037
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.1612 0.5447 0.5447
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0016 0.0013 0.0022
Leishmania major trypanothione reductase 0.0034 0.0077 0.0115
Schistosoma mansoni transient receptor potential channel 4 0.0117 0.0359 0.0694
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.0224 0.0675
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0001 0.0002
Mycobacterium ulcerans DNA gyrase subunit B 0.295 1 1
Mycobacterium tuberculosis Probable two component sensor kinase 0.0121 0.037 0.037
Trypanosoma cruzi DNA topoisomerase III, putative 0.0212 0.068 0.102
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0001 0.0002
Echinococcus granulosus dna polymerase eta 0.0037 0.0087 0.0262
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0001 0.0004
Giardia lamblia DNA topoisomerase II 0.0863 0.2897 1
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0121 0.037 0.0514
Echinococcus granulosus neuropeptide receptor A26 0.0191 0.0608 0.1838
Plasmodium vivax glutathione reductase, putative 0.0034 0.0077 0.0077
Schistosoma mansoni DNA topoisomerase II 0.0983 0.3307 0.6408
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0001 0.0004
Trypanosoma brucei heat shock protein, putative 0.0215 0.0692 0.1037
Onchocerca volvulus 0.0012 0.0001 0.0002
Brugia malayi Transient-receptor-potential like protein 0.0044 0.0108 0.0327
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0001 0.0002
Loa Loa (eye worm) TOPoisomerase family member 0.0983 0.3307 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0029 0.006 0.0115
Plasmodium falciparum ataxin-2 like protein, putative 0.0069 0.0195 0.0195
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0039 0.0039
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0079 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0004
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0212 0.068 0.2057
Trypanosoma brucei heat shock protein, putative 0.0215 0.0692 0.1037
Echinococcus granulosus heat shock protein 90 0.0094 0.0281 0.0849
Trypanosoma brucei PAB1-binding protein , putative 0.0069 0.0195 0.0293
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 0.2051 0.694 0.694
Brugia malayi Importin beta-1 subunit 0.0021 0.0033 0.0099
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0038 0.0088 0.0177
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0016 0.0013 0.0041
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0039 0.0039
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0497 0.1652 0.32
Trypanosoma cruzi importin beta-1 subunit, putative 0.0017 0.0019 0.0028
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0039 0.0119
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0121 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.054 0.1797 0.5435
Entamoeba histolytica hypothetical protein 0.0017 0.0019 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0001 0.0004
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0116 0.0354 0.0354
Giardia lamblia Heat shock protein HSP 90-alpha 0.0094 0.0281 0.0969
Trypanosoma brucei importin beta-1 subunit, putative 0.0021 0.0033 0.0049
Loa Loa (eye worm) hypothetical protein 0.0117 0.0359 0.1084
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.1971 0.667 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0039 0.0076
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0094 0.0281 0.0281
Onchocerca volvulus 0.0016 0.0014 0.0045
Echinococcus multilocularis transient receptor potential ion channel A 0.0113 0.0345 0.0697
Leishmania major DNA topoisomerase 1A 0.0212 0.068 0.102
Echinococcus multilocularis cpg binding protein 0.0018 0.0022 0.0045
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Echinococcus multilocularis heat shock protein 90 0.0215 0.0692 0.1396
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0868 0.2625
Brugia malayi MH2 domain containing protein 0.0074 0.0212 0.064
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1467 0.4953 1
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.5161 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0032 0.0068 0.0204
Brugia malayi Intermediate filament tail domain containing protein 0.0012 0.0001 0.0002
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0044 0.0109 0.022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0056 0.0085
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0868 0.2625
Toxoplasma gondii thioredoxin reductase 0.0034 0.0077 0.013
Mycobacterium tuberculosis Possible two component sensor kinase 0.0121 0.037 0.037
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0121 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.0054
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0121 0.037 0.0747
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0001 0.0002
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0369 0.1215 0.3673
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0044 0.0108 0.0218
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0121 0.037 0.0555
Mycobacterium ulcerans beta-lactamase 0.0016 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0043
Schistosoma mansoni heat shock protein 0.0049 0.0125 0.0242
Giardia lamblia DNA topoisomerase III 0.0212 0.068 0.2348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0001 0.0004
Brugia malayi heat shock protein 90 0.0215 0.0692 0.2091
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0049 0.0125 0.0395
Schistosoma mansoni heat shock protein 0.0215 0.0692 0.134
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0085 0.0255
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0043
Plasmodium vivax heat shock protein 90, putative 0.0049 0.0125 0.0125
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0013 0.0005 0.0007
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0121 0.037 0.037
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0038 0.0088 0.017
Schistosoma mansoni cpg binding protein 0.0018 0.0022 0.0043
Toxoplasma gondii Hsp90 domain-containing protein 0.0049 0.0125 0.0212
Trypanosoma cruzi heat shock protein 85, putative 0.0215 0.0692 0.1037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0039 0.0059
Schistosoma mansoni UDP-glucose 4-epimerase 0.004 0.0097 0.0188
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0497 0.1652 0.2476
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0121 0.037 0.037
Brugia malayi DNA topoisomerase III 0.0212 0.068 0.2057
Trichomonas vaginalis heat shock protein, putative 0.0215 0.0692 0.2091
Plasmodium falciparum heat shock protein 90, putative 0.0049 0.0125 0.0125
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0001 0.0002
Plasmodium vivax thioredoxin reductase, putative 0.0034 0.0077 0.0077
Entamoeba histolytica DNA topoisomerase II, putative 0.0983 0.3307 1
Brugia malayi CXXC zinc finger family protein 0.0018 0.0022 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0001 0.0004
Toxoplasma gondii DNA topoisomerase 2, putative 0.0983 0.3307 0.5623
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0229 0.0739 0.2234
Trypanosoma brucei UDP-galactose 4-epimerase 0.0042 0.0103 0.0155
Brugia malayi Endoplasmin precursor 0.0215 0.0692 0.2091
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 0.2051 0.694 0.694
Trypanosoma cruzi heat shock protein 85, putative 0.0215 0.0692 0.1037
Trypanosoma cruzi heat shock protein 85, putative 0.0094 0.0281 0.0421
Trichomonas vaginalis heat shock protein, putative 0.0169 0.0536 0.1619
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0001 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0056 0.0085
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0037 0.0085 0.0256
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.0224 0.0451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0056 0.0085
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0039 0.0039
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0772 0.2587 0.3878
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0868 0.2625
Trypanosoma brucei heat shock protein 90, putative 0.0215 0.0692 0.1037
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0056 0.0085
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Trypanosoma cruzi DNA topoisomerase II, putative 0.0772 0.2587 0.3878
Treponema pallidum heat shock protein 90 0.0094 0.0281 0.0281
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Trichomonas vaginalis glucosylceramidase, putative 0.0407 0.1344 0.4065
Plasmodium vivax heat shock protein, putative 0.0049 0.0125 0.0125
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0407 0.1344 0.4065
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0497 0.1652 0.2476
Loa Loa (eye worm) hypothetical protein 0.0369 0.1215 0.3673
Echinococcus granulosus carbonic anhydrase 0.0369 0.1215 0.3673
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0001 0.0002
Echinococcus granulosus geminin 0.0796 0.2668 0.8066
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.004 0.0097 0.0295
Schistosoma mansoni carbonic anhydrase-related 0.0369 0.1215 0.2353
Brugia malayi glutaminase DH11.1 0.0272 0.0886 0.2679
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0004
Onchocerca volvulus Glucosylceramidase homolog 0.0267 0.0868 0.2739
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0001 0.0002
Brugia malayi Pre-SET motif family protein 0.0263 0.0856 0.2587
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.1612 0.5447 0.9263
Onchocerca volvulus 0.0016 0.0014 0.0045
Plasmodium falciparum ataxin-2 like protein, putative 0.0069 0.0195 0.0195
Echinococcus multilocularis GPCR, family 2 0.0025 0.0046 0.0093
Echinococcus multilocularis transient receptor potential gamma protein 0.0117 0.0359 0.0723
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Schistosoma mansoni alpha-glucosidase 0.0123 0.038 0.0735
Echinococcus granulosus transient receptor potential ion channel A 0.0113 0.0345 0.1043
Toxoplasma gondii heat shock protein HSP90 0.0215 0.0692 0.1175
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.295 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0001 0.0002
Echinococcus multilocularis dna polymerase eta 0.0037 0.0087 0.0175
Loa Loa (eye worm) transcription factor SMAD2 0.0074 0.0212 0.064
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.174 0.5881 1
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0001 0.0004
Mycobacterium tuberculosis Probable oxidoreductase 0.0087 0.0257 0.0257
Echinococcus granulosus short transient receptor potential channel 6 0.0078 0.0224 0.0675
Schistosoma mansoni endoplasmin 0.0215 0.0692 0.134
Echinococcus multilocularis geminin 0.0796 0.2668 0.5385
Echinococcus granulosus intermediate filament protein 0.0012 0.0001 0.0001
Echinococcus granulosus transient receptor potential gamma protein 0.0117 0.0359 0.1084
Trichomonas vaginalis glucosylceramidase, putative 0.0407 0.1344 0.4065
Trypanosoma cruzi major cysteine proteinase, putative 0.0022 0.0036 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0068 0.0102
Echinococcus multilocularis rho GTPase activating protein 20 0.0212 0.068 0.1373
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0001 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0059
Leishmania major heat shock protein, putative 0.0049 0.0125 0.0188
Trypanosoma brucei Heat shock protein 83, putative 0.0215 0.0692 0.1037
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0039 0.0059
Schistosoma mansoni transient receptor potential channel 0.0078 0.0224 0.0433
Echinococcus granulosus beta LACTamase domain containing family member 0.0016 0.0014 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0868 0.2625
Leishmania major developmentally regulated phosphoprotein-like protein 0.0121 0.037 0.0555
Mycobacterium tuberculosis Probable esterase LipL 0.0016 0.0014 0.0014
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0212 0.068 0.1373
Mycobacterium tuberculosis Probable reductase 0.0079 0.0227 0.0227
Trichomonas vaginalis esterase, putative 0.0016 0.0014 0.0043
Brugia malayi Hsp90 protein 0.0049 0.0125 0.0378
Leishmania major hypothetical protein, conserved 0.0069 0.0195 0.0293
Plasmodium falciparum heat shock protein 90 0.0215 0.0692 0.0691
Toxoplasma gondii melibiase subfamily protein 0.0044 0.0109 0.0186
Schistosoma mansoni heat shock protein 0.0215 0.0692 0.134
Leishmania major mitochondrial DNA topoisomerase II 0.1971 0.667 1
Plasmodium vivax DNA gyrase subunit B, putative 0.295 1 1
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Loa Loa (eye worm) hypothetical protein 0.0044 0.0108 0.0327
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0056 0.0085
Leishmania major DNA polymerase eta, putative 0.0037 0.0087 0.0131
Brugia malayi Latrophilin receptor protein 2 0.0025 0.0046 0.014
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0039 0.0119
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0143 0.0447 0.1353
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0001 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.008 0.0233 0.0706
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0001 0.0003
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0121 0.037 0.1119
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0016 0.0013 0.0013
Leishmania major DNA polymerase kappa, putative 0.0023 0.0039 0.0059
Plasmodium falciparum DNA topoisomerase 3, putative 0.0212 0.068 0.068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0001 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0056 0.0085
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0001 0.0003
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.1612 0.5447 0.5447
Trypanosoma brucei DNA topoisomerase III, putative 0.0212 0.068 0.102
Trypanosoma brucei heat shock protein, putative 0.0215 0.0692 0.1037
Trichomonas vaginalis receptor histidine kinase, putative 0.0121 0.037 0.1119
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0004
Brugia malayi hypothetical protein 0.0069 0.0195 0.059
Loa Loa (eye worm) hypothetical protein 0.008 0.0233 0.0706
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0016 0.0013 0.002
Schistosoma mansoni transient receptor potential channel 0.0078 0.0224 0.0433
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0068 0.0205
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0012 0.0001 0.0002
Trypanosoma brucei heat shock protein, putative 0.0215 0.0692 0.1037
Plasmodium falciparum DNA topoisomerase 2 0.0983 0.3307 0.3307
Trypanosoma cruzi UDP-galactose 4-epimerase, putative 0.004 0.0097 0.0146
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0116 0.0354 0.0354
Brugia malayi Disco-interacting protein 2 homolog 0.0021 0.0032 0.0096
Leishmania major heat shock protein 83-1 0.0215 0.0692 0.1037
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0212 0.068 0.2057
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0001 0.0003
Echinococcus granulosus carbonic anhydrase II 0.0497 0.1652 0.4994
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0407 0.1344 0.4065
Trichomonas vaginalis heat shock protein, putative 0.0094 0.0281 0.085
Echinococcus granulosus lysosomal alpha glucosidase 0.0143 0.0447 0.1352
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0099
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.1971 0.667 1
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0212 0.068 0.2056
Trypanosoma brucei importin beta-1 subunit, putative 0.0021 0.0033 0.0049
Mycobacterium leprae Probable two component sensor kinase MprB 0.0121 0.037 0.0514
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0497 0.1652 0.4994
Trichomonas vaginalis mercuric reductase, putative 0.0012 0 0.0001
Leishmania major hypothetical protein, conserved 0.0016 0.0014 0.0021
Onchocerca volvulus 0.0018 0.0022 0.0071
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0497 0.1652 0.4994
Schistosoma mansoni hypothetical protein 0.0229 0.0739 0.1431
Chlamydia trachomatis DNA gyrase subunit A 0.0191 0.0611 0.0611
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0121 0.037 0.037
Loa Loa (eye worm) MH2 domain-containing protein 0.0074 0.0212 0.064
Loa Loa (eye worm) thioredoxin reductase 0.0034 0.0077 0.0233
Leishmania major GTP-binding protein, putative 0.0016 0.0013 0.002
Trichomonas vaginalis rotamase, putative 0.0013 0.0005 0.0014
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0121 0.037 0.037
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.0917 0.2773
Echinococcus multilocularis short transient receptor potential channel 6 0.0078 0.0224 0.0451
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0094 0.0281 0.0849
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0121 0.037 0.037
Brugia malayi Glycosyl hydrolases family 31 protein 0.0032 0.0068 0.0205
Onchocerca volvulus 0.0021 0.0032 0.01
Echinococcus granulosus histone lysine methyltransferase setb 0.0038 0.0088 0.0266
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0001 0.0003
Mycobacterium ulcerans hypothetical protein 0.0016 0.0014 0.0014
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0001 0.0002
Leishmania major cathepsin L-like protease 0.0028 0.0056 0.0085
Trypanosoma brucei heat shock protein, putative 0.0215 0.0692 0.1037
Toxoplasma gondii hypothetical protein 0.0369 0.1215 0.2065
Trypanosoma brucei DNA topoisomerase III, putative 0.0212 0.068 0.102
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0001 0.0004
Trypanosoma brucei heat shock protein, putative 0.0215 0.0692 0.1037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0001 0.0004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.008 0.0233 0.0706
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0212 0.068 0.1156
Toxoplasma gondii LsmAD domain-containing protein 0.0069 0.0195 0.0332
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0001 0.0002
Trypanosoma cruzi Heat shock protein 83, putative 0.0215 0.0692 0.1037
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0943 0.317 1
Schistosoma mansoni microtubule-associated protein tau 0.028 0.0913 0.1768
Echinococcus multilocularis lysosomal alpha glucosidase 0.0143 0.0447 0.0903
Trichomonas vaginalis D-aminoacylase, putative 0.0016 0.0014 0.0043
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0016 0.0013 0.002
Trichomonas vaginalis penicillin-binding protein, putative 0.0016 0.0014 0.0043
Echinococcus granulosus lamin 0.0012 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0796 0.2668 0.5169
Plasmodium vivax DNA topoisomerase II, putative 0.0983 0.3307 0.3307
Brugia malayi Glycosyl hydrolases family 31 protein 0.0143 0.0447 0.1353
Mycobacterium tuberculosis Probable dehydrogenase 0.0079 0.0227 0.0227
Onchocerca volvulus 0.0012 0.0001 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0121 0.037 0.037
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0013 0.0005 0.0007
Brugia malayi kinase, mitochondrial precursor 0.0121 0.037 0.1119
Brugia malayi beta-lactamase family protein 0.0016 0.0014 0.0043
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0121 0.037 0.037
Onchocerca volvulus 0.0212 0.068 0.2146
Loa Loa (eye worm) endoplasmin 0.0215 0.0692 0.2091
Trichomonas vaginalis glucosylceramidase, putative 0.0407 0.1344 0.4065
Loa Loa (eye worm) CXXC zinc finger family protein 0.0018 0.0022 0.0068
Schistosoma mansoni hypothetical protein 0.0025 0.0046 0.0089
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0039 0.0118
Loa Loa (eye worm) heat shock protein 75 0.0049 0.0125 0.0378
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0212 0.068 0.2057
Trypanosoma brucei trypanothione reductase 0.0034 0.0077 0.0115
Trypanosoma cruzi DNA topoisomerase II, putative 0.0772 0.2587 0.3878
Echinococcus granulosus disco interacting protein 2 0.0021 0.0032 0.0095
Schistosoma mansoni cpg binding protein 0.0018 0.0022 0.0043
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0016 0.0013 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0868 0.2625
Entamoeba histolytica DNA topoisomerase III, putative 0.0212 0.068 0.2057
Loa Loa (eye worm) intermediate filament protein 0.0012 0.0001 0.0002
Entamoeba histolytica Ran family GTPase 0.0016 0.0013 0.0041
Loa Loa (eye worm) UDP galactose 4'-epimerase 0.004 0.0097 0.0295
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0039 0.0119

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 5.31 uM PUBCHEM_BIOASSAY: Confirmation dose response assay for compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2227, AID2246] ChEMBL. No reference
EC50 (functional) > 40 uM PUBCHEM_BIOASSAY: HTS Dose response counterscreen for assays utilizing the enzyme, beta-galactosidase - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1966, AID2569] ChEMBL. No reference
IC50 (functional) = 7.891 um PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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