Detailed information for compound 1879309

Basic information

Technical information
  • TDR Targets ID: 1879309
  • Name: [4-[(Z)-[(4-chlorobenzoyl)hydrazinylidene]met hyl]phenyl] thiophene-2-carboxylate
  • MW: 384.836 | Formula: C19H13ClN2O3S
  • H donors: 1 H acceptors: 2 LogP: 4.88 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(=O)N/N=C\c1ccc(cc1)OC(=O)c1cccs1
  • InChi: 1S/C19H13ClN2O3S/c20-15-7-5-14(6-8-15)18(23)22-21-12-13-3-9-16(10-4-13)25-19(24)17-2-1-11-26-17/h1-12H,(H,22,23)/b21-12-
  • InChiKey: XVABESYUXCHTBC-MTJSOVHGSA-N  


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Synonyms

  • [4-[(Z)-[(4-chlorobenzoyl)hydrazono]methyl]phenyl] thiophene-2-carboxylate
  • 2-thiophenecarboxylic acid [4-[(Z)-[[(4-chlorophenyl)-oxomethyl]hydrazono]methyl]phenyl] ester
  • thiophene-2-carboxylic acid [4-[(Z)-[(4-chlorobenzoyl)hydrazono]methyl]phenyl] ester
  • [4-[(Z)-[(4-chlorophenyl)carbonylhydrazinylidene]methyl]phenyl] thiophene-2-carboxylate
  • BAS 01231463
  • ST5248641
  • Thiophene-2-carboxylic acid 4-[(4-chloro-benzoyl)-hydrazonomethyl]-phenyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens acid phosphatase 1, soluble Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii Dullard family phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01090 protein phosphatase [EC3.1.3.16], putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis Dullard-like phosphatase domain containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus CTD small phosphatase protein like Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense TFIIF-stimulated CTD phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans C terminus of potential Low molecular weight phosphoTyrosine Phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani dullard-like phosphatase domain containing protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva nuclear LIM interactor-interacting factor 1, putative Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA Get druggable targets OG5_127571 All targets in OG5_127571
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Schistosoma japonicum CTD small phosphatase-like protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) phosphotyrosine protein phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans 3' exon of potential Low molecular weight phosphoTyrosine Phosphatase gene Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Nuclear LIM interactor-interacting factor 1 Get druggable targets OG5_127075 All targets in OG5_127075
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des) acid phosphatase 1, soluble 112 aa 107 aa 24.3 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Trypanosoma brucei TFIIF-stimulated CTD phosphatase, putative CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 260 aa 263 aa 27.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0226 0.6081 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0364 0.0364
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0277 0.0455
Onchocerca volvulus Cathepsin L homolog 0.002 0.0277 0.0315
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.147 0.147
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.0364
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0364 0.0584
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.188 0.188
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0129 0.0212
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.3411 0.5609
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0015 0.0129 0.0212
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.007 0.1671 0.1671
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0015 0.0129 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0277 0.0455
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.3411 0.3411
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.016 0.016
Leishmania major DNA polymerase kappa, putative 0.0023 0.0364 0.0238
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.188 0.188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.188 0.188
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.3411 0.5602
Trypanosoma cruzi ISWI complex protein 0.0018 0.0227 0.0227
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.3411 0.5329
Giardia lamblia DINP protein human, muc B family 0.0023 0.0364 0.0395
Loa Loa (eye worm) fibroinase 0.002 0.0277 0.0441
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.0364
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0364 0.1067
Leishmania major DNA polymerase eta, putative 0.0054 0.1232 0.1118
Brugia malayi Cathepsin L-like precursor 0.002 0.0277 0.0455
Leishmania major hypothetical protein, conserved 0.0018 0.0227 0.01
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0364 0.0598
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0277 0.0811
Plasmodium vivax vivapain-2 0.002 0.0277 0.3914
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1782 0.5225
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0015 0.0129 0.0129
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.6081 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0277 0.0455
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.013
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.6081 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0277 0.0455
Brugia malayi PHD-finger family protein 0.0032 0.0611 0.1005
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.6081 1
Echinococcus multilocularis zinc finger protein 0.0026 0.0429 0.1258
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0364 0.1067
Trichomonas vaginalis dullard protein, putative 0.0015 0.0129 0.0212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.188 0.188
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0707 0.1162
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.3411 0.5609
Loa Loa (eye worm) ctsf protein 0.002 0.0277 0.0441
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0364 0.0364
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0309 0.0905
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.3411 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.188 0.188
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0707 0.1162
Loa Loa (eye worm) hypothetical protein 0.0015 0.0129 0.0198
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0707 0.1162
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0156 0.4116 0.7876
Onchocerca volvulus Cathepsin L homolog 0.002 0.0277 0.0315
Schistosoma mansoni cpg binding protein 0.0039 0.0806 0.2362
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.4578 0.4578
Brugia malayi Cathepsin L-like precursor 0.0014 0.0088 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0277 0.0455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.188 0.188
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.3411 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0364 0.0364
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0277 0.0455
Schistosoma mansoni hypothetical protein 0.0018 0.0227 0.0667
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1415 0.1415
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0226 0.6081 1
Schistosoma mansoni zinc finger protein 0.0018 0.0227 0.0667
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0707 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.016 0.016
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0287 0.0842
Loa Loa (eye worm) cysteine protease 0.002 0.0277 0.0441
Leishmania major cathepsin L-like protease 0.002 0.0277 0.015
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0364 0.0364
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0364 0.0364
Brugia malayi 6-phosphofructokinase 0.0131 0.3411 0.5609
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.0364
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0009 0.0026
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.6081 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0277 0.0455
Onchocerca volvulus 0.002 0.0277 0.0315
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.188 0.188
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0931 0.2729
Leishmania major cathepsin L-like protease 0.0077 0.188 0.1774
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0364 0.0598
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.0364
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.3411 0.6396
Trichomonas vaginalis dullard protein, putative 0.0015 0.0129 0.0212
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0364 0.0598
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.0364
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.0364
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0707 0.1162
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.0364
Brugia malayi Bromodomain containing protein 0.0046 0.1011 0.1663
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0277 0.0811
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.3411 1
Echinococcus multilocularis cpg binding protein 0.0039 0.0806 0.2362
Leishmania major hypothetical protein, conserved 0.007 0.1671 0.1563
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.007 0.0115
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0707 0.0971
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0277 0.0455
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.1232 0.1232
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0707 0.1162
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.3411 0.5609
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0129 0.0212
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.6081 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.188 0.188
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.3411 0.5602
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0015 0.0129 0.1824
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0707 0.1162
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.1692 0.1692
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.1671 0.2748
Brugia malayi CXXC zinc finger family protein 0.0035 0.0685 0.1126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0277 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0088 0.0145
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.188 0.188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0277 0.0455
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0364 0.1067
Echinococcus multilocularis dna polymerase eta 0.0054 0.1232 0.3612
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0308 0.0493
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.1232 0.1232
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0088 0.0258
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.1232 0.2026
Brugia malayi 6-phosphofructokinase 0.0131 0.3411 0.5609
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0088 0.0145
Brugia malayi Cathepsin L-like precursor 0.002 0.0277 0.0455
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0088 0.0145
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0707 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0277 0.0811
Brugia malayi cathepsin L-like precursor 0.0014 0.0088 0.0145
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0277 0.3914
Leishmania major cathepsin L-like protease 0.002 0.0277 0.015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0277 0.0455
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.0364
Brugia malayi Cathepsin L-like precursor 0.0014 0.0088 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0277 0.0455
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0277 0.0455
Toxoplasma gondii hypothetical protein 0.0059 0.1366 0.8182
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0287 0.0842
Leishmania major DNA polymerase eta, putative 0.0038 0.0778 0.0658
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0277 0.0811
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0277 0.0455
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.016 0.016
Echinococcus granulosus dna polymerase kappa 0.0023 0.0364 0.1067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0277 0.0455
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0707 0.3822
Trypanosoma brucei ISWI complex protein 0.0018 0.0227 0.0227
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0707 1
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0277 0.0277
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0685 0.1113
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0287 0.0842
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0309 0.0905
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0364 0.1067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0277 0.0455
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0309 0.0905
Leishmania major cathepsin L-like protease 0.0077 0.188 0.1774
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.4578 0.4507
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0277 0.0455
Onchocerca volvulus 0.002 0.0277 0.0315
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0277 0.0441
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0277 0.3914
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0277 0.0455
Brugia malayi Cathepsin L-like precursor 0.002 0.0277 0.0455
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.1153 0.1153
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0364 0.0364
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0277 0.0455
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.1671 0.2748
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0364 0.0598
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.1797 0.5267
Loa Loa (eye worm) phosphofructokinase 0.0131 0.3411 0.5602
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0364 0.0364
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.1641 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.1153 0.1153
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.5128 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.6081 1
Echinococcus granulosus dna polymerase eta 0.0054 0.1232 0.3612
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0277 0.0441
Loa Loa (eye worm) hypothetical protein 0.0021 0.0309 0.0494
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0931 0.2729
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0707 0.5
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.4578 0.4578
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.3411 0.3325
Schistosoma mansoni zinc finger protein 0.0026 0.0429 0.1258
Toxoplasma gondii cathepsin CPL 0.002 0.0277 0.0977
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.3411 0.5609
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.013
Brugia malayi Cathepsin L-like precursor 0.002 0.0277 0.0455
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.0129 0.1824
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0277 0.0455
Loa Loa (eye worm) hypothetical protein 0.002 0.0277 0.0441
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0707 0.3822
Onchocerca volvulus Cathepsin F homolog 0.002 0.0277 0.0315
Plasmodium vivax vivapain-2 0.002 0.0277 0.3914
Brugia malayi Bromodomain containing protein 0.0093 0.2318 0.3812
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1671 0.1671
Onchocerca volvulus 0.002 0.0277 0.0315
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0707 0.3822
Echinococcus multilocularis cysteine protease 0.002 0.0277 0.0811
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.053 0.1554
Loa Loa (eye worm) hypothetical protein 0.0085 0.2117 0.3471
Echinococcus granulosus cathepsin l1 0.002 0.0277 0.0811
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.0364
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 1 1
Onchocerca volvulus 0.002 0.0277 0.0315
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0277 0.3914
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0364 0.1067
Schistosoma mansoni hypothetical protein 0.0025 0.0409 0.12
Leishmania major cathepsin L-like protease 0.002 0.0277 0.015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0277 0.0455
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0778 0.0778
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.053 0.1554
Trypanosoma cruzi ISWI complex protein 0.0018 0.0227 0.0227
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.3411 0.5609
Echinococcus granulosus CTD small phosphatase protein like 0.0015 0.0129 0.0378
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0707 0.1162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0277 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0277 0.0455
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0778 0.4295
Loa Loa (eye worm) hypothetical protein 0.0015 0.0124 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0129 0.0129
Brugia malayi Cathepsin L-like precursor 0.002 0.0277 0.0455
Echinococcus multilocularis cysteine protease 0.002 0.0277 0.0811
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0277 0.0811
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.053 0.1554
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0409 0.0659
Echinococcus granulosus cathepsin l1 0.0014 0.0088 0.0258
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.3411 1
Trypanosoma brucei unspecified product 0.0016 0.016 0.016
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0015 0.0129 0.0378
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0226 0.6081 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.3411 0.3411
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0277 0.0455
Schistosoma mansoni DNA polymerase eta 0.0054 0.1232 0.3612
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0277 0.0811
Onchocerca volvulus 0.002 0.0277 0.0315
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0277 0.0455
Loa Loa (eye worm) hypothetical protein 0.0053 0.1215 0.1987
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0129 0.0378
Loa Loa (eye worm) hypothetical protein 0.0049 0.1095 0.1788
Trichomonas vaginalis dullard protein, putative 0.0015 0.0129 0.0212
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.3411 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0277 0.0455
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 1 1
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.0129 0.1824
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0129 0.0212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.188 0.188
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0129 0.0212
Schistosoma mansoni bromodomain containing protein 0.0078 0.1919 0.5625
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0015 0.0129 0.0378
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.3411 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0277 0.0455
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0009 0.0026
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0277 0.0811
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.188 0.188
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.3411 0.5609
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0226 0.6081 1
Brugia malayi phosphofructokinase 0.0131 0.3411 0.5609
Loa Loa (eye worm) hypothetical protein 0.0054 0.1232 0.2014
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0364 0.0238
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0707 0.1162
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.1153 0.1153
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0707 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.188 0.188
Onchocerca volvulus 0.002 0.0277 0.0315
Loa Loa (eye worm) hypothetical protein 0.0046 0.1014 0.1655
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.1671 0.1671
Onchocerca volvulus 0.002 0.0277 0.0315
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0277 0.0455
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.188 0.188
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 1 1
Echinococcus multilocularis 0.0015 0.0129 0.0378
Leishmania major cathepsin L-like protease 0.002 0.0277 0.015
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.1797 0.5267
Schistosoma mansoni hypothetical protein 0.0015 0.0124 0.0363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0088 0.0145
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0287 0.0842
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0129 0.0378
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0277 0.0811
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0309 0.0905
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.6081 1
Leishmania major cysteine peptidase A (CPA) 0.002 0.0277 0.015
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0226 0.6081 1
Leishmania major cathepsin L-like protease 0.002 0.0277 0.015
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.1153 0.1153
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.6081 1
Trypanosoma brucei unspecified product 0.0023 0.0364 0.0364
Echinococcus granulosus cpg binding protein 0.0039 0.0806 0.2362
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0277 0.0455
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.3411 0.5609
Schistosoma mansoni cpg binding protein 0.0035 0.0685 0.2008
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0707 1
Mycobacterium ulcerans hypothetical protein 0.0192 0.5128 0.8333
Trypanosoma brucei unspecified product 0.0016 0.016 0.016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0277 0.0455
Leishmania major cathepsin L-like protease 0.0077 0.188 0.1774
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.188 0.188
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0014 0.0088 0.013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.188 0.188
Echinococcus granulosus zinc finger protein 0.0026 0.0429 0.1258
Onchocerca volvulus 0.0035 0.0685 0.0996
Schistosoma mansoni cpg binding protein 0.0039 0.0806 0.2362

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2.157 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120] ChEMBL. No reference
IC50 (functional) 4.51 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in an orthogonal absorbance-based assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 11.4 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2512 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 2.1331 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 67.0158 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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